Cancer Research
A Journal AmericanAssociation Association for Research A Journal of of thethe American forCancer Cancer Research Volume 69 • Number 12 Reviews Antitumor Activity with CYP17 Blockade Indicates That Castration-Resistant Prostate Cancer Frequently Remains Hormone-Driven. Gerhardt Attard, Alison H.M. Reid, David Olmos, and Johann S. DeBono ..............................................................................4937 Bispecific T-Cell Engaging Antibodies for Cancer Therapy. Patrick A. Baeuerle and Carsten Reinhardt.........................................4941 Therapeutic Potential of ‘‘Rexinoids’’ in Cancer Prevention and Treatment. Takemi Tanaka and Luigi M. De Luca .............................4945
Perspective Cancer Genome Sequencing—An Interim Analysis. Edward J. Fox, Jesse J. Salk, and Lawrence A. Loeb ........................................................4948
Meeting Report Breast Cancer Metastasis: Challenges and Opportunities. Jing Lu, Patricia S. Steeg, Janet E. Price, Savitri Krishnamurthy, Sendurai A. Mani, James Reuben, Massimo Cristofanilli, Gabriela Dontu, Luc Bidaut, Vicente Valero, Gabriel N. Hortobagyi, and Dihua Yu ...........................4951
Priority Reports Endogenous Tumor Suppression Mediated by PTEN Involves Survivin Gene Silencing. Minakshi Guha, Janet Plescia, Irwin Leav, Jing Li, Lucia R. Languino, and Dario C. Altieri ..................................4954 Infrequent Detection of Germline Allele-Specific Expression of TGFBR1 in Lymphoblasts and Tissues of Colon Cancer Patients. Kishore Guda, Leanna Natale, James Lutterbaugh, Georgia L. Wiesner, Susan Lewis, Stephan M. Tanner, Jerneja Tomsic, Laura Valle, Albert de la Chapelle, Robert C. Elston, Joseph Willis, and Sanford D. Markowitz..................................................................4959
Cell, Tumor, and Stem Cell Biology Activation of Rap1 Promotes Prostate Cancer Metastasis. Candice L. Bailey, Patrick Kelly, and Patrick J. Casey.............................4962 HOXA13 Promotes Cancer Cell Growth and Predicts Poor Survival of Patients with Esophageal Squamous Cell Carcinoma. Zhen-Dong Gu, Lu-Yan Shen, Hua Wang, Xiao-Mei Chen, Yong Li, Tao Ning, and Ke-Neng Chen ..................................................................................4969 ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence. Lijun Jia, Maria S. Soengas, and Yi Sun ..........................4974 N-myc Downstream Regulated Gene 1/Cap43 Suppresses Tumor Growth and Angiogenesis of Pancreatic Cancer through Attenuation of Inhibitor of B Kinase Expression. Fumihito Hosoi, Hiroto Izumi, Akihiko Kawahara, Yuichi Murakami, Hisafumi Kinoshita, Masayoshi Kage, Kazuto Nishio, Kimitoshi Kohno, Michihiko Kuwano, and Mayumi Ono ....................................................................................4983
June 15, 2009 • Pages 4937–5268 Abrogating Drug Resistance in Malignant Peripheral Nerve Sheath Tumors by Disrupting Hyaluronan-CD44 Interactions with Small Hyaluronan Oligosaccharides. Mark G. Slomiany, Lu Dai, Paul A. Bomar, Thomas J. Knackstedt, D. Alex Kranc, Lauren Tolliver, Bernard L. Maria, and Bryan P. Toole...................................................................................4992 PUMA Suppresses Intestinal Tumorigenesis in Mice. Wei Qiu, Eleanor B. Carson-Walter, Shih Fan Kuan, Lin Zhang, and Jian Yu........4999 Extracellular Engagement of 6 Integrin Inhibited Urokinase-Type Plasminogen Activator–Mediated Cleavage and Delayed Human Prostate Bone Metastasis. Michael O. Ports, Ray B. Nagle, Gerald D. Pond, and Anne E. Cress.........................................................5007 Notch Activation Induces Akt Signaling via an Autocrine Loop to Prevent Apoptosis in Breast Epithelial Cells. Olivier Meurette, Spyros Stylianou, Rebecca Rock, Giovanna M. Collu, Andrew P. Gilmore, and Keith Brennan ................................................................................5015 Critical Role for Caspase-8 in Epidermal Growth Factor Signaling. Darren Finlay, Amy Howes, and Kristiina Vuori ....................................5023 Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis. Georgia Agiostratidou, Maomi Li, Kimita Suyama, Ines Badano, Rinat Keren, Su Chung, Amy Anzovino, James Hulit, Binzhi Qian, Boumediene Bouzahzah, Eliseo Eugenin, Olivier Loudig, Greg R. Phillips, Joseph Locker, and Rachel B. Hazan ...........................5030 The Activated Notch1 Signal Pathway Is Associated with Gastric Cancer Progression through Cyclooxygenase-2. Tien-Shun Yeh, Chew-Wun Wu, Kai-Wen Hsu, Wan-Jung Liao, Min-Chieh Yang, Anna Fen-Yau Li, An-Ming Wang, Min-Liang Kuo, and Chin-Wen Chi ..................................5039 TOB1 Is Regulated by EGF-Dependent HER2 and EGFR Signaling, Is Highly Phosphorylated, and Indicates Poor Prognosis in Node-Negative Breast Cancer. Mike W. Helms, Dirk Kemming, Christopher H. Contag, Heike Pospisil, Kai Bartkowiak, Alice Wang, Sheng-Yung Chang, Horst Buerger, and Burkhard H. Brandt.................5049 Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression. Rachelle L. Dillon, Richard Marcotte, Bryan T. Hennessy, James R. Woodgett, Gordon B. Mills, and William J. Muller ..................................................5057
Epidemiology Genetic Variants on Chromosome 15q25 Associated with Lung Cancer Risk in Chinese Populations. Chen Wu, Zhibin Hu, Dianke Yu, Liming Huang, Guangfu Jin, Jie Liang, Huan Guo, Wen Tan, Mingfeng Zhang, Ji Qian, Daru Lu, Tangchun Wu, Dongxin Lin, and Hongbing Shen.................................................................................5065
Experimental Therapeutics, Molecular Targets, and Chemical Biology In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT. Sylvestor A. Moses, M. Ahad Ali, Song Zuohe, Lei Du-Cuny, Li Li Zhou, Robert Lemos, Nathan Ihle, A. Geoffrey Skillman, Shuxing Zhang, Eugene A. Mash, Garth Powis, and Emmanuelle J. Meuillet..................5073
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Contents (Continued) Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1–Dependent Pathway in Multiple Myeloma. Jing Zhang, Martin Sattler, Giovanni Tonon, Clemens Grabher, Samir Lababidi, Alexander Zimmerhackl, Marc S. Raab, Sonia Vallet, Yiming Zhou, Marie-Astrid Cartron, Teru Hideshima, Yu-Tzu Tai, Dharminder Chauhan, Kenneth C. Anderson, and Klaus Podar .................................................5082 Effects of Vandetanib on Lung Adenocarcinoma Cells Harboring Epidermal Growth Factor Receptor T790M Mutation In vivo. Eiki Ichihara, Kadoaki Ohashi, Nagio Takigawa, Masahiro Osawa, Atsuko Ogino, Mitsune Tanimoto, and Katsuyuki Kiura.......................5091 Human Schwannomas Express Activated Platelet-Derived Growth Factor Receptors and c-kit and Are Growth Inhibited by Gleevec (Imatinib Mesylate). Joydeep Mukherjee, Deepak Kamnasaran, Anand Balasubramaniam, Ivan Radovanovic, Gelareh Zadeh, Tim-Rasmus Kiehl, and Abhijit Guha ...............................................5099 Role of Cell Cycle in Epidermal Growth Factor Receptor Inhibitor-Mediated Radiosensitization. Aarif Ahsan, Susan M. Hiniker, Mary A. Davis, Theodore S. Lawrence, and Mukesh K. Nyati................5108 Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic Adenoviruses. Robert Strauss, Pavel Sova, Ying Liu, Zong Yi Li, Sebastian Tuve, David Pritchard, Paul Brinkkoetter, Thomas Möller, Oliver Wildner, Sari Pesonen, Akseli Hemminki, Nicole Urban, Charles Drescher, and André Lieber .......................................................5115 Targeting Tumor Endothelial Marker 8 in the Tumor Vasculature of Colorectal Carcinomas in Mice. Stephen Fernando and Bradley S. Fletcher .....................................................................5126 Direct Targeting of the Mucin 1 Oncoprotein Blocks Survival and Tumorigenicity of Human Breast Carcinoma Cells. Deepak Raina, Rehan Ahmad, Maya Datt Joshi, Li Yin, Zekui Wu, Takeshi Kawano, Baldev Vasir, David Avigan, Surender Kharbanda, and Donald Kufe ....5133
Regulation of DNA Polymerase by the LMP1 Oncoprotein of EBV through the Nuclear Factor-B Pathway. Nathalie Faumont, Christophe Le Clorennec, Pierre Teira, Gauthier Goormachtigh, Jean Coll, Yvan Canitrot, Christophe Cazaux, Jean-Sébastien Hoffmann, Pierre Brousset, Georges Delsol, Jean Feuillard, and Fabienne Meggetto .............................5177 Estrogen-Related Receptor Expression and Function Is Associated with the Transcriptional Coregulator AIB1 in Breast Carcinoma. Stefanie Heck, Joachim Rom, Verena Thewes, Natalia Becker, Beatrix Blume, Hans Peter Sinn, Ulrich Deuschle, Christof Sohn, Andreas Schneeweiss, and Peter Lichter................................................5186 CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis. Yu Wang, Jisheng Li, Yan Cui, Ting Li, Ka Man Ng, Hua Geng, Henan Li, Xing-sheng Shu, Hongyu Li, Wei Liu, Bing Luo, Qian Zhang, Tony Shu Kam Mok, Wei Zheng, Xiaoyan Qiu, Gopesh Srivastava, Jun Yu, Joseph J.Y. Sung, Anthony T.C. Chan, Dalong Ma, Qian Tao, and Wenling Han ...............5194 Androgen Receptor Expression in Prostate Cancer Cells Is Suppressed by Activation of Epidermal Growth Factor Receptor and ErbB2. Changmeng Cai, David C. Portnoy, Hongyun Wang, Xinnong Jiang, Shaoyong Chen, and Steven P. Balk ...............................5202 A Novel Type of p53 Pathway Dysfunction in Chronic Lymphocytic Leukemia Resulting from Two Interacting Single Nucleotide Polymorphisms within the p21 Gene. Gillian G. Johnson, Paul D. Sherrington, Anthony Carter, Ke Lin, Triantafillos Liloglou, John K. Field, and Andrew R. Pettitt ......................................................5210 Mechanism of Regulation and Suppression of Melanoma Invasiveness by Novel Retinoic Acid Receptor- Target Gene Carbohydrate Sulfotransferase 10. Xiansi Zhao, Carole Graves, Sarah J. Ames, David E. Fisher, and Remco A. Spanjaard...............................................5218
Prevention Immunology Inhibition of Transforming Growth Factor-–Mediated Immunosuppression in Tumor-Draining Lymph Nodes Augments Antitumor Responses by Various Immunologic Cell Types. Takuya Fujita, Koji Teramoto, Yoshitomo Ozaki, Jun Hanaoka, Noriaki Tezuka, Yasushi Itoh, Tohru Asai, Shozo Fujino, Keiichi Kontani, and Kazumasa Ogasawara....5142 Donor CD4 T Cells Are Critical in Allogeneic Stem Cell Transplantation against Murine Solid Tumor. Yoriyuki Kamiryo, Masatoshi Eto, Hisakata Yamada, Toshiki Yajima, Masahiko Harano, Ario Takeuchi, Katsunori Tatsugami, Masumitsu Hamaguchi, Seiji Naito, and Yasunobu Yoshikai ...........................................................................5151
Molecular Biology, Pathobiology, and Genetics
Biological Significance of Prolactin in Gynecologic Cancers. Vera V. Levina, Brian Nolen, YunYun Su, Andrew K. Godwin, David Fishman, Jinsong Liu, Gil Mor, Larry G. Maxwell, Ronald B. Herberman, Miroslaw J. Szczepanski, Marta E. Szajnik, Elieser Gorelik, and Anna E. Lokshin.....................................................5226
Systems Biology and Emerging Technologies Quantitative Assessment of the Complex Dynamics of G1, S, and G2-M Checkpoint Activities. Paolo Ubezio, Monica Lupi, Davide Branduardi, Paolo Cappella, Edoardo Cavallini, Valentina Colombo, Giada Matera, Claudia Natoli, Daniela Tomasoni, and Maurizio D’Incalci...................5234
Microalterations of Inherently Unstable Genomic Regions in Rat Mammary Carcinomas as Revealed by Long Oligonucleotide Array-Based Comparative Genomic Hybridization. Tatjana Adamovic, Donna McAllister, Victor Guryev, Xujing Wang, Jaime Wendt Andrae, Edwin Cuppen, Howard J. Jacob, and Sonia L. Sugg ..............................5159
Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte. Si Brask Sonne, Kristian Almstrup, Marlene Dalgaard, Agnieszka Sierakowska Juncker, Daniel Edsgard, Ludmila Ruban, Neil J. Harrison, Christian Schwager, Amir Abdollahi, Peter E. Huber, Søren Brunak, Lise Mette Gjerdrum, Harry D. Moore, Peter W. Andrews, Niels E. Skakkebaek, Ewa Rajpert-De Meyts, and Henrik Leffers .........5241
The mRNA-Destabilizing Protein Tristetraprolin Is Suppressed in Many Cancers, Altering Tumorigenic Phenotypes and Patient Prognosis. Sarah E. Brennan, Yuki Kuwano, Nadim Alkharouf, Perry J. Blackshear, Myriam Gorospe, and Gerald M. Wilson.............................................5168
Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization. Petr Novak, Taylor J. Jensen, James C. Garbe, Martha R. Stampfer, and Bernard W. Futscher ......................................5251
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Contents (Continued) Tumor Microenvironment White Adipose Tissue Cells Are Recruited by Experimental Tumors and Promote Cancer Progression in Mouse Models. Yan Zhang, Alexes Daquinag, Dmitry O. Traktuev, Felipe Amaya-Manzanares, Paul J. Simmons, Keith L. March, Renata Pasqualini, Wadih Arap, and Mikhail G. Kolonin...........................................................................5259
Corrections Correction: Article on VDR Polymorphisms and Ovarian Cancer..............................................................................5267 Correction: Article on DNA Copy Number Alterations in Ovarian Cancer .....................................................................................5267
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69 (12) Cancer Res 2009;69:4937-5267.
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