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TRANSCRIPT UBERKULOSIS PEDOMAN DIAGNOSIS&PENATALAKSANAANDI INDONESIA Perhimpunan DokterParu Indoneia! # 1. PENDAHULUAN7. TB PADA KEADAAN KHUSUS 2. PATOGENESIS8. KOMPLIKASI 3. KLASIFIKASI TUBERKULOSIS9. DOTS4. DIAGNOSIS10. LAMPIRAN5. PENGOBATAN TUBERKULOSIS11. DAFTAR PUSAKA6. RESISTEN GANDA / MULTI DRUG RESISTANE !MDR BAB IPENDAHULUAN A. EPIDEMIOLOGI T#$%&'#()*+* !TB ,%&#-' ,*( '%*% ,*&' -%+ + #+ ++. P# 1992 World Health Organization !HO %( ,%' #$%&'#()*+**%$+ « Global Emergency ». L-)& HO # 2004 ,%' $ %&88 #'*#* $&# #$%&'#()*+* - # 2002 39 # ( '*#* BTA !B*+( T A*, -)*++:.S%-%& + -%##' #+ %( %&+:%'*+ '#, #$%&'#()*+* ,%#&# &%+)(HO #,( %&$%*& '*#* TB %&+ + A*+ %& +# 33 ; &+ *%(#&# '*#* TB +#+ ,# $+( +(+ &+ #,( -%##' %&- 182 '*#* -%& 100.000 -%##'. D+ A:&+' ,-+& 2 '(+ (%$+ $%*& &+ A*+ %& +# 350 -%& 100.000 -%##' *%-%&+%&(+ - $%( 1 D+-%&'+&' ' '%,+ '+$ TB ( 8000 *%+- &+ 2 < 3 # *%+- #.L-)& HO # 2004 ,%%$#' $ #,( %&$%*& '%, + '+$ TB %&- + A*+ %& +# 625.000 )& # ' ,)&(++ *%$%*& 39 )& -%& 100.000-%##'. A' ,)&(++ %&++ %&- + A:&+' +# 83 -%& 100.000 -%##' &%=(%* HI> #'#- ++ ,%'+$' -%+' %- '*#* TB ,##(. Tabel 1. Perkiraan insidens TB dan angka mortaliti ! ! #$mla% kas$s&'ib$()as$s *er 1 *end$d$k P%,$+ Sep 20, 2017 %&HOS%,# '*#* !; S-##, -)*++:S%,# '*#* !; S-##, -)*++: A:&+'2354 !26 LAPSUS TB (/lapsus-tb) 1000350149 A,%&+'370 !4 1654319M%+%&+ +,#&622 !7 27912455E&)-472 !5 2115424 A*+ T%&2890 !33 129418281P*+:+' B&2090 !24 93912255G()$(8797 !100 288714163 I)%*+ ,*+ ,%%,-+ #&# '% 3 + #+ ##' #,( '*#* TB *%%( I+ +. S% +- # %&- 250.000 '*#* $&# TB *%'+& 140.000 '%,+ '+$ TB. D+I)%*+ #$%&'# ()*+* ( -%,$## ),)& *# +& -%'+ ,%#(& ,%&#-'-%%$$ '%,+ ),)& + *%%( %'+ # -%'+ -%&-* '# -*%(#&# '( #*+. B.DE+INI,I T#$%&'#()*+* ( -%'+ +*%$$' )(% +:%'*+ Mycobacteriumtuberculosis ),-(%? -.BIOMOLE)ULE' M.Tuberculosis Morologi dan ,tr$kt$r Bakteri Mycobacterium tuberculosis $%&$%#' $ (#&#* # *%+'+ ,% (%'# +' $%&*-)& +' $%&'-*#(. B'%&+ ++ $%&#'#& (%$& 03 @ 06 ,, - 1 @ 4 ,,.D++ M. tuberculosis * '),-(%'* %&+&+ &+ (-+* (%,' #'#- ++ !60; .P%#*# #, + + *%( M. tuberculosis +( *, ,+')( (+(+ '),-(%'* !),-(%?