American Contact Dermatitis Society Excellence in Occupational & Contact Dermatitis Research, Practice & Education
ABSTRACTS American Contact Dermatitis Society 16th Annual Meeting February 17, 2005 Hilton New Orleans Riverside New Orleans, LA
Visit ACDS at www.contactderm.org
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2005 Sponsors The American Contact Dermatitis Society wishes to thank those organizations listed below for their support of the society’s educational programs in 2005.
Platinum Level • Connetics Corporation • Cosmetic, Toiletry & Fragrance Association Gold Level
• • • • • •
Allerderm Laboratories CollaGenex Ferndale Fujisawa Health Care, Inc. Novartis Procter & Gamble
Silver Level • Dormer/Chemotechniques • Mary Kay • Pharmaceutical Specialties Patrons • Biersdorf • Galderma • Neutrogena • Summer Labs
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Table of Contents American Contact Dermatitis Society 16th Annual Meeting Hilton New Orleans Riverside Ballroom B New Orleans, LA February 17, 2005
Schedule of Events Exhibitor Listing Abstracts Summary Abstracts
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The ACDS Annual Meeting is a full day focused on current issues in contact dermatitis and occupational skin diseases. Presentations include abstract and poster presentations on state-ofthe-art research in the basic, applied and clinical science of contact dermatitis.
Ticketed Events There is no additional charge for these tickets, however, space is limited and reservations required. If you do not have tickets for any of these events, please check availability with the registration desk. Breakfast Symposium Roundtable Luncheon Cocktail Reception
Fisher Resident Awards Residents are eligible for the Fisher Resident Awards for the best oral abstract presentations. Eligible presenters are denoted with an asterisk following their presentation.
Verification of Attendance/Evaluation You will receive evaluation forms for the meeting in your registration packet. Please complete the form and deposit them in the collection box at the registration desk following the meeting. Appropriate credit for attendance should be ascertained and reported by individual physicians to the particular state or medical society to which he or she belongs. A certificate of attendance will be provided to all registrants.
CME Credits The American Contact Dermatitis Society’s Annual Meeting certifies that this educational activity has been recognized for a maximum of 6 credit hours in Category I and may be applied towards the American Academy of Dermatology Continuing Medical Education Award. Program: 532-100
ACDS Membership Membership in ACDS is open to dermatologists, physicians, researchers and medical professionals with an interest in dermatitis and occupational dermatology. Membership information can be found at www.contactderm.org.
Dermatitis Dermatitis the official journal of the American Society of Contact Dermatitis. This quarterly, peer-reviewed journal, under the direction of Editor-in-Chief Ponciano D. Cruz, MD, provides clinically focused articles on diagnosis and treatment of dermatologic conditions caused by irritants and allergic reactions. Available online, Dermatitis, is searchable and accessible anywhere there is an internet connection. The journal is free with an ACDS membership or to order a subscription please, call 1-800-568-7281 or visit www.bcdecker.com.
Disclosure Statement The American Contact Dermatitis Society requires balance, independence, objectivity and scientific rigor in all of its educational activities. The Board of Directors requires that all presenters and audience members comply with all applicable laws and regulations governing disclosure.
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Schedule of Events 7:00 AM
Registration Open
7:30 AM
ACDS Breakfast Symposium Grand Salon 15/18 David Cohen, MD: Therapies for Facial Dermatitis Sponsored by CollaGenex
8:30 AM
Welcome to the 16th ACDS Annual Meeting Grand Ballroom B Anthony Gaspari, MD, ACDS President Bruce Brod, MD, ACDS Annual Meeting Committee Chair
8:35 AM
General Session Linda Moreau, MD, FRCP: Allergic Contact Dermatitis Associated with Reactive Dyes in a Dark Garment: A Case Report* Kim Eickhorst, MD: Rue the Herb: Ruta Graveolens Associated Phytophototoxicity* Denise Aaron, MD: Burden and Bother of Dermatitis in Patients Referred to a NACDG Center for Patch Testing* Giuseppe Militello, MD: The Utility of the TRUE Test in a Private Practice Setting* Anna A. Bar, MD: Antigenicity of Patch Test Allergens Over Time* Krista Shackelford, MD: Adverse Events from Patch Testing: A Case Report of Pemphigus Foliaceous and Epidermal Detachment* Divya Srivastava, MD: Identification of the Constituents of Balsam of Peru in Tomatoes* Mary Sheu, MD: Allergic Contact Dermatitis from Tom's of Maine Natural Deodorant: A Report of 4 Cases Associated with Lichen Acid Mix Allergy* Golara Honari, MD: The Utility of Patch Testing with Topical Medicaments as an Adjunct to Standard Screening Panels* Dan Slodownik, MD: Allergic Contact Cheilitis and Stomatitis to Toothpastes in Israeli Patients* ** Peter C. Schalock, MD: Efficacy and Patient Perception of Grenz Ray Therapy in the Treatment of Dermatoses Refractory to Other Medical Therapy* Samara Mimesh, MD: ACD to Corticosteroids: Reproducibility of Patch Testing and Correlation with Intradermal Testing*
8:45 AM 8:55 AM 9:05 AM 9:15 AM 9:25 AM 9:35 AM 9:45 AM 9:55 AM 10:05 AM 10:15 AM 10:25 AM
Grand Ballroom B
10:35 AM
Break/Exhibits/Posters Posters in Grand Salon 10/7
Grand Salon 10/7
11:00 AM
James Yiannias, MD: Update on ACDS Databases.
* Candidates for the Alexander A. Fisher Resident Award. ** Howard I. Maibach International Travel Award recipient.
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11:05 AM
Occupational Dermatology Symposium: The Donald J. Birmingham Occupational Skin Diseases Symposium is supported by the National Occupation Research Agenda (NORA). Moderated by Boris Lushniak, MD
11:05 AM 11:15 AM
D Linn Holness, MD: Dermatologist Occupational Disease Practice Survey Linda Moreau, MD, FRCP: Occupational Allergic Contact Dermatitis From Triphenyl Phosphite* 11:25 AM Curtis P. Hamann, MD: Prevalence of Latex Allergy in Dental Professionals in Japan and the United States 11:35:00 AM Albert Wolkerstorfer, MD: Unexpected Exposure to Nickel in Electroplating 11:45:00 AM Malin Frick, MD: Poor Correlation Between Stated and Found Conctrations of Isocyanates in Patch-Test Preparations 11:55:00 AM Alexander Zemtsov, M.D., MSC: Occupational Allergic Contact Dermatitis from Sodium Lauroyl Sarcosinate in the Liquid Soap 12:05 PM
ACDS Roundtable Lunch Sponsored by Allerderm
1:30 AM
General Session Ronald Brancaccio, MD and David Cohen, MD: Remembering Alexander Fisher
1:40 AM
Alexander Fisher Lecture Melanie Pratt, MD: The Role of Mentoring in the Field of Contact Dermatitis
2:30 AM
ACDS Awards
2:45 PM 2:55 PM
Douglas L. Powell, MD: Cutaneous Reactions to Silicone Klaus-Peter Wilhelm, MD: Proclivity to Cumulative Skin Irritation: Dependence Upon Age and Sex
3:05 PM
Break/Posters/Exhibits Posters in Grand Salon 10/7
3:35 PM
4:25 PM
Mark Davis, MD: Back to Basics: In Calculating Patch Test Reactions, Should Macular Erythema and Lesser Reactions be Included? Vinod Kumar Sharma, MD: Evolution of Clinical Pattern of Parthenium Dermatitis: A Study of 74 Cases** Susanne Astner, MD: In-vivo confocal microscopy of contact dermatitis Cecilia Svedman, MD: Contact Allergy to Metals After Percutaneous Transluminal Coronary Angioplasty (PTCA) and Stenting** Mark Davis, MD: Patch Testing to the Dust Mite (Dermatophagoides Mix 0.1%): High Rate of Reaction in Both Atopic and Nonatopic Patients Rochelle R. Torgerson, MD, PhD: Contact Sensitivities in Oral Disease
4:35 PM
ACDS Business Meeting
5:00 PM
Cocktail Reception Sponsored by Ferndale Laboratories
3:45 PM 3:55 PM 4:05 PM 4:15 PM
* Candidates for the Alexander A. Fisher Resident Award. ** Howard I. Maibach International Travel Award recipient.
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Grand Salon 15/18
Jasperwood
Exhibitors ACDS invites attendees to visit the following exhibitors located in the Grand Ballroom B behind the general session. Breakfast and morning and afternoon breaks will be served in the exhibit area.
Allerderm Laboratories PO Box 5295 Phoenix, AZ 85010 Phone: 602225-0595 Email:
[email protected] Web site: www.allerderm.com
T.R.U.E. Test ® patch test system - see the new updated 2005 Physician Reference Manual and patient education materials. Discover what is new with FINN Chambers ® applicatoins and learn about our new products Lubrex ® Cream and Lubrex ® Cleanser, Advance Treatment for damaged hands.
Chemotechnique/Dormer Laboratories 91 Kelfield Street, Unit 5 Toronto, ON M9W 5A3 Canada Phone: 416242-6167 Email:
[email protected] Web site: www.dormer.com
Chemotechnique is a world leader in patch testing providing over 350 allegens and accessories. Chemotechnique cooperates with research groups (ICDRS, NACDG, etc.) to advance the study of contact dermatitis. Dormer Labs is the North American distributor.
Connetics Corporation 3290 West Bayshore Road Palo Alto, CA 94303 Phone: 650843-2840 Email:
[email protected] Web site:
Connetics currently has three innovate foam-based products: Luxiq, a mid-potency steroid, OLUX, a super-potent topical steroid, and Evoclin, a topical treatment for acne, which are delivered through our proprietary VersaFoam ® brand delivery system. Our fourth product, Soriatane, is an oral medication for the treatment of severe psoriasis.
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Delfin Technologies P.O.Box 1199 70211 Kuopio, Finland Phone: 358 17 441 2340 Email:
[email protected] Web site: www.delfintech.com
Professional equipment for measuring water loss and hydration of the skin.
Ferndale Laboratories Inc. 780 W Eight Mile Road Ferndale, MI 48220 Phone: 248548-0900 Email:
[email protected] Web site: www.ferndalelabs.com
Ferndale Laboratories is dedicated to achieving the latest technological advances and committed to bringing unique, value-added therapies to heal, protect, and beutify the skin. Our products include: Locoid Lipocream ® (hydrocortisone butyrate 0.1%), Pramosene (R) (hydrocortisone acetate 1% or 2.5% and pramoxine hydrochloride 1%), L.M.X. 4 (R) (lidocaine 4%), Nouriva Repair (R), SBR Lipocream (R).
Pharmaceutical Specialties 1620 Industrial Drive NW Rochester, MN 55901 Phone: 800325-8232 Email:
[email protected] Web site: www.psico.com
Skin care products free of fragrance, masking fragrance, dyes, parabens, lanolin and formaldehyde. Line includes Vanicream and Free & Clear.
Tara Pharmaceuticals 5 Skyline Drive Hawthorne, NY 10532 Phone: 914345-9001 Email:
[email protected] Web site: www.taro.com
Taro is a multinational, science-based pharmaceutical company dedicated to meeting the needs of its customers through the discovery, development, manufacturing and marketing of the highest quality healthcare products.
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ABSTRACT SUMMARY
11 Linda Moreau, MD, FRCP 12 Kim Eickhorst, MD
13 Denise Aaron, MD 14 Giuseppe Militello, MD 15 Anna A. Bar, MD 16 Krista Shackelford, MD 17 Divya Srivastava, MD 18 Mary Sheu, MD 19 Golara Honari, MD 20 Dan Slodownik, MD 21 Peter C. Schalock, MD 22 Samara Mimesh, MD 23 James Yiannias, MD 24 D Linn Holness, MD 25 Linda Moreau, MD, FRCP
26 Curtis P. Hamann, MD 27 Albert Wolkerstorfer, MD 28 Malin Frick, MD 29 Alexander Zemtsov, M.D., MSC
30 Melanie Pratt, MD 31 Douglas L. Powell, MD 32 Klaus-Peter Wilhelm, MD 33 Mark Davis, MD 34 Vinod K. Sharma, MD 35 Susanne Astner, MD 36 Cecilia Svedman, MD
Allergic Contact Dermatitis Associated with Reactive Dyes in a Dark Garment: A Case Report Rue the Herb: Ruta Graveolens Associated Phytophototoxicity Burden and Bother of Dermatitis in Patients Referred to a NACDG Center for Patch Testing The Utility of the TRUE Test in a Private Practice Setting Antigenicity of Patch Test Allergens Over Time Adverse Events from Patch Testing: A Case Report of Pemphigus Foliaceous and Epidermal Detachment Identification of the Constituents of Balsam of Peru in Tomatoes Allergic Contact Dermatitis from Tom's of Maine Natural Deodorant: A Report of 4 Cases Associated with Lichen Acid Mix Allergy The Utility of Patch Testing with Topical Medicaments as an Adjunct to Standard Screening Panels Allergic Contact Cheilitis and Stomatitis to Toothpastes in Israeli Patients Efficacy and Patient Perception of Grenz Ray Therapy in the Treatment of Dermatoses Refractory to Other Medical Therapy ACD to Corticosteroids: Reproducibility of Patch Testing and Correlation with Intradermal Testing Modern Electronic Methods To Facilitate The Management Of Allergic Contact Dermatitis Dermatologist Occupational Disease Practice Survey Occupational Allergic Contact Dermatitis From Triphenyl Phosphite Prevalence of Latex Allergy in Dental Professionals in Japan and the United States Unexpected Exposure to Nickel in Electroplating Poor Correlation Between Stated and Found Conctrations of Isocyanates in Patch-Test Preparations Occupational Allergic Contact Dermatitis from Sodium Lauroyl Sarcosinate in the Liquid Soap The Role of Mentoring in the Field of Contact Dermatitis Cutaneous Reactions to Silicone Proclivity to Cumulative Skin Irritation: Dependence Upon Age and Sex Back to Basics: In Calculating Patch Test Reactions, Should Macular Erythema and Lesser Reactions be Included? Evolution of Clinical Pattern of Parthenium Dermatitis: A Study of 74 Cases In-vivo confocal microscopy of contact dermatitis Contact Allergy to Metals After Percutaneous Transluminal Coronary Angioplasty (PTCA) and Stenting
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37 Mark Davis, MD 38 Rochelle Torgerson, MD,
Patch Testing to the Dust Mite (Dermatophagoides Mix 0.1%): High Rate of Reaction in Both Atopic and Nonatopic Patients Contact Sensitivities in Oral Disease
PhD
Abstracts: Posters 39
Tove Agner, MD
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Susun An Sachin Bhardwaj, MD
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Normita Chua-Vivar, MD
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Mark Davis, MD
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Joseph Fowler MD
45 46 47
Marcos Hervella, MD Soogan Celeste Lalla, MD Eunyoung Lee
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Meltem Onder, MD
49 50 51
Mario C. Pires, MD Mario C. Pires, MD Erik Zimerson, MD
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Short-term effects of alcohol-based disinfectant and detergent on skin irritation Influence of vehicles on the induction of skin irritation A Double-blind, Randomized, Placebo-Controlled Trial Comparing Topical Immunomodulating Agents and Corticosteroids for Treatment of Experimentally Induced Moringa Oleifera Leaf Extract as Active Antibacterial Property in a Bar Soap: A Randomized, Double-Blind, Pacebo-Controlled Trial Delayed Readings of Patch Test Reactions to Topical Corticosteroids: Low Yield A Comparator Study of an Adjunctive Dermal Lipid Replacement Foam (Restoraderm ® in the Management of Refractory Hand Contact Dermatitis Paraben "Para-" Doxes Patch Testing in Children with Dermatitis A Study of Influencing Factors for Sensory Irritation Due to Preservatives of Cosmetics Common Contact Sensitizers in Ankara, Turkey: A Study of 1585 Patients with the European Standard Series Contact Dermatitis to Latanoprost Contact Dermatitis in Children Photoallergic Contact Dermatitis from Ketoprofen in Southern Sweden
Allergic Contact Dermatitis associated with Reactive Dyes in a dark Garment: A case report Linda Moreau, MD ∗, An Goossens, PhD ± ∗McGill University Health Center, Montreal, Quebec, Canada ±Contact Allergy Unit, Department of Dermatology, Katholieke Universiteit Leuven, Leuven, Belgium We present a case of a patient who has not been occupationally exposed to reactive dyes, but did present with a dermatitis from wearing a dark cotton garment. The patient experienced reactivation of his dermatitis when rewearing a new unwashed dark T-shirt made of 100% cotton (in fact the patient reported that it had to be washed at least 3 times before the skin reaction disappeared). He presented positive patch tests to 6 reactive dyes from Chemotechnique® textile series. The clothing could not be proven as the true cause of the dermatitis, but resolution occurred upon removal of the suspected garment. This suggests that contact allergy to the reactive dyes (he did not react to any other dyes and his garment was a natural fabric) was likely responsible. Reactive dye allergies (both type I and IV) have mainly occurred in occupational settings (1,2,3). With this report, we would like to emphasize that reactive dyes, as a class, should be considered as potential allergens, both occupationally and from non-occupational exposure such as garments. If garments containing reactive dyes are not properly rinsed in the manufacturing process, we believe excess dye can be retained that may cause allergic contact dermatitis. Since the reactive dyes and their hydrolysis products are very water-soluble, they can be easily washed off to prevent allergic contact dermatitis. Acknowledgments: Authors would like to thank the ACDS sponsorship mentoring award program. References: 1. Estlander T. Allergic dermatoses and respiratory diseases from reactive dyes. Contact Dermatitis 1988: 18: 290-297 2. Thoren K, Meding B, Nordlinder R, Belin L. Contact dermatitis and asthma from reactive dyes. Contact dermatitis 1986: 15: 186-193 3.WILKINSON SM, MCGECHAEN K. OCCUPATIONAL ALLERGIC CONTACT DERMATITIS FROM REACTIVE DYES. CONTACT DERMATITIS 1996: 35: 376 Notes:
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RUE THE HERB: RUTA GRAVEOLENS ASSOCIATED PHYTOPHOTOTOXICITY Kimberly Eickhorst, MD of St Luke’s-Roosevelt Hospital, Department of Dermatology, New York, NY; Vincent DeLeo, MD of St Luke’s-Roosevelt Hospital, Department of Dermatology, New York, NY We present an unusual case of phytophototoxicity induced by an herbal plant from the Rutaceae family, called Ruta graveolens. The presentation describes a nine-member extended family who came into contact with the Rue herb during an outdoor excursion and who subsequently had exposure to the outdoor sun. Despite application of sunscreen (SPF 30) all family members later experienced some form of photoirritant contact dermatitis. The presentation describes an interesting case of photoirritant contact dermatitis, compares and contrasts photoirritant with photoallergic contact dermatitis, explores the causes of phytophototoxicity on a molecular level regarding R. graveolens, and reviews the presentation, course, and treatment recommendations of phytophototoxicity reactions. Notes:
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BURDEN AND BOTHER OF DERMATITIS IN PATIENTS REFERRED TO A NACDG CENTER FOR PATCH TESTING Denise M. Aaron MD, Kathryn A. Zug MD, Todd MacKenzie PhD Dartmouth-Hitchcock Medical Center. Lebanon, NH. This IRB-approved study evaluates baseline skin-related quality of life (QOL) in patients presenting for patch testing. A cross-section of patients (n=107) presenting to Dartmouth-Hitchcock Medical Center's patch test clinic between October 2002 and June 2004 completed an anonymous skin-related QOL survey, Skindex-16+5. Skindex-16+5, a validated QOL tool, assesses the bother of skin disease in four cardinal areas: symptoms, emotions, functioning, and occupational impact. Responses are indexed from 0 (never bothered) to 100 (always bothered). All patients presenting for patch testing were significantly bothered by how their skin disease impacted emotional functioning (index=66, SD=27) and by symptoms (index=60, SD=25), especially itch and irritation. Patients with hand dermatitis fared much worse in all four areas (index= +16 to +28, p