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FARMACIA, 2011, Vol. 59, 6
COMPARISON BETWEEN COCKROFT-GAULT AND MDRD FORMULA FOR THE ESTIMATION OF GLOMERULAR FILTRATION RATE IN CHRONIC KIDNEY DISEASE PATIENTS CARMEN CĂLDĂRARU1*, MARIA T DOGARU2, CAMIL E. VARI2, SILVIA IMRE2, GRIGORE DOGARU1 1
Nephrology Department, University of Medicine and Pharmacy, Gheorghe Marinescu street 38, RO-540139, Târgu-Mures, Romania 2 Faculty of Pharmacy, University of Medicine and Pharmacy, Gheorghe Marinescu street 38, RO-540139, Târgu-Mures, Romania *corresponding author:
[email protected] Abstract The purpose of this study was to determine the concordance between two equations used for estimating glomerular filtration rate, in order to verify the possibility to be used interchangeably in the clinical practice. We present a retrospective study performed on a group of 258 patients with chronic kidney disease treated between January 2008 and December 2009 in the Department of Nephrology of The County Hospital Targu Mures, Romania. For every patient, glomerular filtration rate (GFR) was estimated with Cockroft-Gault (aCG) equation adjusted for body surface (aCG) and abbreviated Modification of Diet in Renal Disease (MDRD) formula (aMDRD). The paired t-test showed that the estimated GFR through the abbreviated MDRD and the corrected CG equations were significantly different from each other (p < 0.0001). There were significant differences between glomerular filtration rate estimated with aCG and aMDRD equations (p