Association between Hepatitis B Virus X Gene Mutations and Clinical ... [PDF]

tions were observed in 8 patients. The double mutation was considered to be a mutational pattern. The frequency of 3 mut

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Gut and Liver, Vol. 5, No. 1, March 2011, pp. 70-76

ORiginal Article

Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection Eun Young Cho*, Chang Soo Choi*, Ji-Hyun Cho†, and Haak Cheoul Kim* Departments of *Internal Medicine and †Laboratory Medicine, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan, Korea

Background/Aims: Few reports have described the association between mutations in the entire X gene of the hepatitis B virus (HBV) and the clinical status of HBV-infected patients. We studied the association between HBV X gene mutations and the disease status of patients infected with HBV genotype C. Methods: Mutations in the HBV X genes of 194 patients were determined by direct sequencing. The subject population consisted of patients with chronic hepatitis (n=60), liver cirrhosis (n=65), and hepatocellular carcinoma (HCC) (n=69). The sequencing results of these 3 groups were compared. Results: Each of the mutations G1386M, C1485T, C1653T, T1753V, A1762T, and G1764A was significantly associated with the patient’s clinical status. The T1753V (pc

Data are presented as number or mean±SD. The significance of differences (p-value) in the indicated group is shown. CH, chronic hepatitis; LC, liver cirrhosis; HCC, hepatocelluar carcinoma; HBeAg, hepatitis B e antigen; HBeAb, hepatitis B e antibody; HBV-DNA, hepatitis B virus-DNA. *p

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