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Cellular Respiration self.Mcat
4
Submitted 2 years ago by Kirschbaum93
This post was submitted on 31 Jul 2015
4 points (76% upvoted) Hi all. So, I've been trying to hammer all the aspects of cellular respiration into my brain, and I find Kaplan incredibly confusing on this and some internet references somehow contradict each other (at least the way I'm interpreting them). I've come up with my own little summary of the major steps, and I want to make sure it's correct.
https://redd.it/3f8b02
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Glycolysis * occurs in the cytoplasm * 1 molecule of glucose gets converted to 2 molecules of pyruvate * rate-limiting enzyme: phosphofructokinase-1 (inhibited by ATP and citrate, induced by AMP) * irreversible enzymes: hexokinase/glucokinase (if in liver), PFK-1, pyruvate kinase * net by-products: 2 ATP, 2 NADH
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Conversion Step * 2 molecules of pyruvate get converted to 2 molecules of acetyl-CoA * happens in mitochondria, only if oxygen is present * net by-products: 2 CO2, 2 NADH * AcetylCoA can then either enter Krebs Cycle or fatty acid synthesis Krebs Cycle * 2 molecules of acetyl CoA get cycled through a series of enzymes and intermediates (in mitochondria) * control points: citrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase * pyruvate dehydrogenase, citrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase all inhibited by NADH and ATP, but isocitrate dehydrogenase is stimulated by ADP and NAD+ * net by-products: 6 NADH, 2 FADH2, 2 ATP, 4 CO2 Electron Transport Chain * in mitochondria; creates proton gradient to produce ATP * regulated by oxygen concentration (stimulated if high, inhibited if low) and ADP (stimulated if high, inhibited if low) * net by-products: 32 ATP NET ATP AEROBIC RESPIRATION: 38 ATP (is this right?) Fermentation * occurs in cytoplasm if no oxygen is available * reduces 2 molecules of pyruvate to 2 molecules of lactate (in humans) or 2 molecules of ethanol (in yeast) * active enzyme: lactate dehydrogenase, regulated by oxygen concentration (stimulated if low, inhibited if high) * net by-products: 2 ATP NET ATP ANAEROBIC RESPIRATION: 4 ATP If all of this is right the way it is, I would be so happy. Edit: Apparently I suck at formatting. Sorry about the congestion... 12 comments share save hide report
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