Chapter 129. Neoplasms of Subcutaneous Fat | Fitzpatrick's

McGraw-Hill Medical


User Services

Quick Reference




Sign In



Study Tools

Patient Ed

Hospital Corner


Search AccessMedicine


Advanced Search

Home > Books > Fitzpatrick's Dermatology in General Medicine, 8e >

Chapter 129. Neoplasms of Subcutaneous Fat Thomas Brenn View



Get Citation

Search Book


Favorite Table | Print View Contents

Neoplasms of Subcutaneous Fat at a Glance

Chapter 129

Adipocyte tumors are the most frequently encountered group of mesenchymal neoplasms. This is due to the high prevalence of lipoma and angiolipoma.

Neoplasms of Subcutaneous Fat: Introduction

Tumors range from entirely benign neoplasms (e.g., lipomas) to those of intermediate malignant potential with risk for local recurrence (e.g., atypical lipomatous tumor) to high-grade pleomorphic sarcomas (e.g., pleomorphic liposarcoma).


Although liposarcoma is the single most frequently encountered sarcoma, the large majority of adipocyte tumors are benign.


The clinical presentation of adipocyte tumors is generally nonspecific. Most adipocyte tumors show distinctive cytogenetic abnormalities that may be of diagnostic value.

Lipomatosis of Nerve (Fibrolipomatous Hamartoma of Nerve)

Treatment is surgical excision. Adjuvant radiation therapy and/or chemotherapy may be of benefit for treatment of malignant tumors that are not amenable to complete excision or in cases of advanced disease.

Nevus Lipomatosus Superficialis Favorite Table | Print

Piezogenic Pedal Papules Precalcaneal Congenital Fibrolipomatous Hamartoma

Lipoma at a Glance Lipoma is the most common soft-tissue tumor.


It is benign and presents in adulthood as a small circumscribed mass. The anatomic distribution is wide with relative

Spindle Cell and Pleomorphic Lipoma

Histologically, the tumors are circumscribed, encapsulated, and composed of mature white adipose tissue.

sparing of the head, hands, and feet.

Chondroid Lipoma


Myolipoma of Soft Tissue

Lipomas are the most common soft-tissue neoplasm. Although they affect individuals in a wide age range, they occur predominantly in adults between the ages of 40 and 60 years; presentation in childhood is rare. There is no gender predilection. Lipomas are multiple in approximately 5% of cases.1

Hibernoma Lipoblastoma/Lipoblastomatosis

Etiology and Pathogenesis

Hemosiderotic Fibrohistiocytic Lipomatous Lesion/Tumor

The majority of lipomas (approximately 75%) show karyotypic abnormalities. The cytogenetic findings are heterogeneous, but rearrangements of 12q13–15 are most common.2–4 Other affected loci are on chromosomes 6


and 13.2–4 Numerical abnormalities are scarce, and most tumors are diploid.

Atypical Lipomatous Tumor/WellDifferentiated Liposarcoma Dedifferentiated Liposarcoma Myxoid/Round Cell Liposarcoma

Clinical Findings The most common presentation is as a painless, slowly enlarging mass involving the subcutaneous tissue of the trunk, neck, or proximal extremities. Involvement of the head, hands, and feet is uncommon. These superficial lipomas are typically small, measuring less than 5 cm.1 Lipomas may be multiple and familial and show a predilection for the arms and thighs in familial multiple lipomatosis (Fig. 129-1).5 The constellation of multiple lipomas, macrocephaly, lymphangiomas, and hemangiomas is known as Bannayan (Bannayan–Zonana) syndrome.6,7 This autosomal dominant disease shares features with other independently described entities and is

Pleomorphic Liposarcoma References

currently also referred to as Bannayan–Riley–Ruvalcaba syndrome.8,9 Further clinical findings include intestinal polyposis, genital pigmented macules, and other hamartomas. The syndrome is caused by mutations in the PTEN gene and belongs to the larger family of PTEN hamartoma-tumor syndromes, including Cowden disease.10–15 Lipomas may also be seen as a manifestation of Gardner's syndrome. Gardner's syndrome is part of the spectrum of familial adenomatous polyposis and includes extracolonic manifestations such as desmoid fibromatosis, osteomas, cysts, and lipomas. FIGURE 129-1

View ...


Sign In Username or Email Password

Get Free Access Through Your Institution

Sign in Forgot Username? Forgot Password?

Contact your institution's library to ask if they subscribe to McGraw-Hill Medical Products.

Sign in via OpenAthens

What is MyAccess?

Sign in via Shibboleth

Subscription Options Pay Per View Timed Access to all of AccessMedicine 24 Hour

48 Hour

$34.95 (USD)

$54.95 (USD)

Buy Now

Buy Now

Best Value

AccessMedicine Full Site: One-Year Individual Subscription



Buy Now View All Subscription Options


McGraw-Hill Medical

Books Library Updates

Multimedia Videos by Category Videos by System Exploring Essential Radiology Patient Safety Modules Female Reproductive System Module Pharmacology Lectures

Quick Reference QMDT Guidelines — Primary Care Guidelines — Inpatient Medicine DDx Diagnostic Tests Clinical Prep 2 Minute Medicine® English-Spanish Dictionary Calculators

Cases Case Files® Family Practice Board Review Fluid/Electrolyte and AcidBase Cases Microbiology Cases Sherris Medical Microbiology Cases Pathophysiology Cases Clinical Neuroanatomy Cases Resident Readiness®: Internal Medicine Acid-Base Disturbances


Patient Ed About AccessMedicine Advisory Board Hospital Corner

Sites AccessAnesthesiology AccessCardiology AccessEmergency Medicine AccessHemOnc AccessMedicina AccessMedicine AccessNeurology AccessObGyn AccessPediatrics AccessPharmacy AccessPhysiotherapy AccessSurgery Case Files Collection Clinical Sports Medicine Collection F.A. Davis PT Collection HarrisonMedicina JAMAevidence Murtagh Collection OMMBID Pharmacotherapy Principles & Practice

Study Tools Review Questions Clerkship Topics Flashcards Play Showdown!

Copyright © McGraw-Hill Global Education Holdings, LLC. All rights reserved. Your IP address is This site uses cookies to provide, maintain and improve your experience. MHE Privacy Center Close

Loading [Contrib]/a11y/accessibility-menu.js .

User Services Librarians Help Submit Feedback Become a Reviewer Privacy Policy Terms of Use Notice Press Subscribe Institutional Subscriptions Individual Subscriptions

Chapter 129. Neoplasms of Subcutaneous Fat | Fitzpatrick's

McGraw-Hill Medical Books User Services Quick Reference Drugs Subscribe Multimedia Sign In English Cases Study Tools Pa...

241KB Sizes 6 Downloads 18 Views

Recommend Documents

No documents