Controversies Concerning the Antiphospholipid Syndrome in Obstetrics [PDF]

Antiphospholipid antibody syndrome is a non-inflammatory autoimmune disease characterized by recurrent thrombotic events

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Previous Article | Vol 13. Num 1. 01 January 2017 | Next article Reumatol Clin 2017;13:30-6 - Vol. 13 Num.1 DOI: 10.1016/j.reumae.2016.04.005

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Review Article

Controversies Concerning the Antiphospholipid Syndrome in Obstetrics Controversias del síndrome de anticuerpos antifosfolipídicos en obstetricia Dulce María Albertina Camarena Cabrera

,

, Claudia Rodriguez-Jaimes , Sandra

© Sociedad Española de Reumatología

Acevedo-Gallegos , Juan Manuel Gallardo-Gaona , Berenice Velazquez-Torres , José Antonio Ramírez-Calvo Servicio de Medicina Materno Fetal, Instituto Nacional de Perinatología, Mexico City, Mexico Received 09 March 2015, Accepted 28 April 2016

© Colegio Mexicano de Reumatología

Abstract

Access for subscribers

Antiphospholipid antibody syndrome is a non-inflammatory autoimmune disease characterized by recurrent thrombotic events and/or obstetric complications associated

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antibodies,

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Antiphospholipid antibodies are a heterogeneous group of autoantibodies associated with recurrent miscarriage, stillbirth, fetal growth restriction and premature birth. The diversity of the features of the proposed placental antiphospholipid antibodies fingerprint suggests that several disease processes may occur in the placentae of women with antiphospholipid antibody syndrome in the form of immune responses: inflammatory events, complement activation, angiogenic imbalance and, less commonly, thrombosis and infarction. Because of the disparity between clinical and laboratory criteria, and the impact on perinatal outcome in patients starting treatment, we reviewed the aspects of antiphospholipid antibody syndrome related to obstetric complications and seronegative antiphospholipid antibody syndrome, and their treatment in obstetrics.

Resumen El síndrome de anticuerpos antifosfolipídicos es una enfermedad autoinmune no inflamatoria, caracterizada por eventos trombóticos recurrentes y/o complicaciones obstétricas, asociados a la presencia de anticuerpos antifosfolipídicos circulantes: anticuerpos anticardiolipina, anti- 2 glucoproteína-I y/o anticoagulante lúpico. Los anticuerpos antifosfolipídicos son un grupo heterogéneo de autoanticuerpos asociados con morbilidad obstétrica, como pérdida gestacional recurrente, muerte fetal, parto pretérmino asociado a insuficiencia placentaria como enfermedad hipertensiva del embarazo y/o restricción del crecimiento intrauterino. Los procesos fisiopatológicos relacionados con la morbilidad obstétrica no se han comprendido del todo, involucrándose múltiples eventos inmunológicos, entre ellos los inflamatorios, la activación del complemento, el desbalance de los factores angiogénicos y, en alguna proporción de los casos, se ha demostrado trombosis e infarto. Debido a la controversia en los criterios clínicos y de laboratorio, así como a la repercusión en la mejora de los resultados perinatales en pacientes que inician tratamiento, decidimos llevar a cabo esta revisión sobre los conceptos de síndrome de anticuerpos antifosfolipídico relacionado con complicaciones obstétricas y síndrome de anticuerpos antifosfolipídico seronegativo, así como su manejo en obstetricia.

Keywords Antiphospholipid antibody syndrome, Obstetric antiphospholipid syndrome, Seronegative antiphospholipid syndrome, Antiphospholipid antibodies, Adverse perinatal outcome

Palabras clave Síndrome de anticuerpos antifosfolipídicos, Síndrome de anticuerpos antifosfolipídicos obstétrico, Síndrome de anticuerpos antifosfolipídicos seronegativo, Anticuerpos antifosfilipídicos, Resultados perinatales adversos N OTI CE Use of undefined constant ACCESSO_INSTITUCIONES - assumed 'ACCESSO_INSTITUCIONES' (includes_ws/librerias/utilidades.php[843]) Article W A R N I N G include(contenidos/static/ayuda_acceso_fr.php): failed to open stream: No such file or directory (includes_ws/contenidos/item.php[219]) W A R N I N G include(): Failed opening 'contenidos/static/ayuda_acceso_fr.php' for inclusion (include_path='.:/var/www/html/includes_ws') (includes_ws/contenidos/item.php[219])

Previous Article | Vol 13. Num 1. 01 January 2017 | Next article Reumatol Clin 2017;13:30-6 - Vol. 13 Num.1 DOI: 10.1016/j.reumae.2016.04.005

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