curriculum vitae - Johns Hopkins Medicine [PDF]

Henry Brem, M.D.

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CURRICULUM VITAE

HENRY BREM, M.D. TABLE OF CONTENTS DEMOGRAPHIC INFORMATION .................................................................................................................................................. 2 RESEARCH ACTIVITIES................................................................................................................................................................. 3 Peer-Reviewed Articles: ................................................................................................................................................................. 3 Editorials, Reviews: ...................................................................................................................................................................... 18 Book Chapters, Monographs: ....................................................................................................................................................... 18 Books: ........................................................................................................................................................................................... 21 Other media (films, videos, CD-ROMS, slide sets): ..................................................................................................................... 21 Inventions, Patents, Copyrights (pending, awarded) .................................................................................................................... 21 Extramural Sponsorships (current, pending, previous): ................................................................................................................ 22 Editorial Activities: ........................................................................................................................................................................... 28 DEVELOPMENT AND FUNDRAISING ACTIVITIES ................................................................................................................ 29 CLINICAL ACTIVITIES ................................................................................................................................................................. 29 ORGANIZATIONAL ACTIVITIES ................................................................................................................................................ 29 Search Committees for Departmental Chairman .......................................................................................................................... 29 Johns Hopkins Academic Committees: ........................................................................................................................................ 30 PROFESSIONAL SOCIETIES: ....................................................................................................................................................... 31 National Committees: ................................................................................................................................................................... 31 Conference Organizer, Session Chair: .......................................................................................................................................... 31 ADVISORY COMMITTEES, REVIEW GROUPS: ........................................................................................................................ 31 Scientific Advisory Committees: .................................................................................................................................................. 31 N.I.H. Study Section – Reviewer: ................................................................................................................................................. 32 Selected Grant Reviews: ............................................................................................................................................................... 32 CONSULTANTSHIPS: .................................................................................................................................................................... 32 Scientific Advisory Boards: .......................................................................................................................................................... 32 Board of Directors: ....................................................................................................................................................................... 33 RECOGNITION ............................................................................................................................................................................... 33 Awards, honors: ............................................................................................................................................................................ 33 Invited Talks, Panels: .................................................................................................................................................................... 34 OTHER PROFESSIONAL ACCOMPLISHMENTS ....................................................................................................................... 49 Abstracts ....................................................................................................................................................................................... 49 Manuscripts in Preparation ........................................................................................................................................................... 72

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CURRICULUM VITAE

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HENRY BREM, M.D.

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_____________________________________ DEMOGRAPHIC INFORMATION Current Appointments:

Date

Harvey Cushing Professor Director, Department of Neurosurgery Professor of Neurosurgery, Ophthalmology, Oncology and Biomedical Engineering Neurosurgeon-in-Chief, Johns Hopkins Medical Institutions Director, Hunterian Neurosurgical Research Center Director, Neurosurgery Pain Research Institute at Johns Hopkins Personal Data: CLINICAL AND ADMINISTRATIVE OFFICE : Johns Hopkins Hospital 1800 Orleans St. / Zayed 6-6115 Baltimore, Maryland 21287 Tel: 410-955-2248 (Patient Off.); 410-955-2252 (Admin Off.) Fax: 410-955-8262 E-mail: [email protected] Date of Birth:

RESEARCH OFFICE Johns Hopkins University School of Medicine 1550 Orleans St / CRB2-2M41 Baltimore, Maryland 21231 Tel: 410-614-0477 / Fax: 410-614-0478

August 14, 1952 Paterson, New Jersey

Education and Training : THESES:

“Mechanism of selected carcinogen-DNA interactions” Biology Honor Thesis, New York University, June 1973. Control of neovascularization” Honor Thesis, Harvard Medical School, 1978.

A.B.

1970 - 1973 1973 - 1974

M.D.

1974 - 1978 1978 - 1979 1979 - 1980 1979 - 1984

New York University, (Cum Laude) Harvard University, Graduate School of Arts and Sciences Department of Biological Chemistry, Harvard Medical School (Cum Laude) Peter Bent Brigham Hospital, General Surgery Resident Johns Hopkins Hospital, Neurosurgery and Ophthalmology, Fellow Neurological Institute of New York, Columbia College of Physicians and Surgeons, Neurosurgery Residency Harvard School of Public Health: Program for Chiefs of Clinical Service

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Professional Experience: Research Assistant (Cardiopulmonary Lab), New York University Medical School Pre-Doctoral Fellow, Microbiology Department, Columbia College of Physician and Surgeons Pre-Doctoral Fellow, Surgery Department, Children's Hospital Medical Center, Boston, MA. Consultant, Wilmer Institute, Johns Hopkins Hospital Fellow (Clinical Surgery), Harvard University Fellow (Neurosurgery & Ophthalmology), Johns Hopkins University Staff Associate (Neurosurgery), Columbia University Assistant Professor of Neurosurgery, Johns Hopkins University Assistant Professor of Oncology, Johns Hopkins University Director, Neurosurgical Oncology, Johns Hopkins Hospital Joint Appointment in Ophthalmology, Johns Hopkins University Associate Professor of Neurosurgery Johns Hopkins University. Associate Professor of Oncology, Johns Hopkins University Director, Hunterian Neurosurgical Research Center Professor, Neurosurgery and Oncology, Johns Hopkins University Vice Chairman, Dept of Neurosurgery, Johns Hopkins University Harvey Cushing Professor Director, Department of Neurosurgery, Johns Hopkins University Co-Functional Unit Director, Clinical Neurosciences, Johns Hopkins Hospital Neurosurgeon-in-Chief, Johns Hopkins Medical Institutions Professor, Biomedical Engineering, Johns Hopkins University Director, Neurosurgery Pain Institute at Johns Hopkins

1967 - 1970 1971 - 1972 1972 - 1978 1975 - 1979 1978 - 1979 1979 - 1980 1983 - 1984 1984 - 1988 1984 - 1989 1984 - 2000 1984 1988 - 1993 1989 - 1993 1991 1993 1995 - 2000 2000 2000 2000 2000 2010 2011- 2013

RESEARCH ACTIVITIES

Peer-Reviewed Articles: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11.

Brem H, Coward JE, Rosenkranz HS. 1,2-dibromoethane--effect on the metabolism and ultrastructure of Escherichia coli. Biochem.Pharmacol. 1974; 23(16): 2345-2347. PMID 4605455. Brem H, Stein AB, Rosenkranz HS. The mutagenicity and DNA-modifying effect of haloalkanes. Cancer Res. 1974; 34(10): 2576-2579. PMID 4607208. Brem H and Folkman J. Inhibition of tumor angiogenesis mediated by cartilage. J.Exp.Med. 1975; 141(2): 427-439. PMID 1113064. PMC2190537. Langer R, Brem H, Falterman K, Klein M, Folkman J. Isolations of a cartilage factor that inhibits tumor neovascularization. Science. 1976; 193(4247): 70-72. PMID 935859. Brem S, Brem H, Folkman J, Finkelstein D, Patz A. Prolonged tumor dormancy by prevention of neovascularization in the vitreous. Cancer Res. 1976; 36(8): 2807-2812. PMID 1277191. Preis I, Langer R, Brem H, Folkman J. Inhibition of neovascularization by an extract derived from vitreous. Am.J.Ophthalmol. 1977; 84(3): 323-328. PMID 900228. Brem H, Thompson D, Long D, Patz A. Human brain tumors: Differences in ability to stimulate angiogenesis. Surgical Forum, 1980; 31, 471-473. Langer R, Brem H, Tapper D. Biocompatibility of polymeric delivery systems for macromolecules. J.Biomed.Mater.Res. 1981; 15(2): 267-277. PMID 7348718. Friedman JH, Brem H, Mayeux R. Global aphasia in multiple sclerosis. Ann.Neurol. 1983; 13(2): 222-223. PMID 6830195. Brem H, Patz J, and Tapper D. Detection of human central nervous system tumors: Use of migration stimulating activity of the cerebrospinal fluid. Surgical Forum. 1983; 34:532-534. Brem H and Stein BMS. Posterior surgical approach to the third ventricle and pineal region. Contemporary Neurosurgery. 1985; 7:1-6.

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Zinreich SJ, Wang H, Epstein JI, Kim WS, Brem H, Anderson JH, Ahn HS, Rosenbaum AE. Carotid bifurcation imaging model for more accurately comparing imaging techniques. Acta Radiol.Suppl. 1986; 36924-28. PMID 2980462. Robey SS, Olson JL, Brem H, Epstein JI. Posterior fossa neuroblastoma occurring in an elderly man. Hum.Pathol. 1988; 19(3): 365-367. PMID 3346012. Steen RG, Tamargo RJ, McGovern KA, Rajan SS, Brem H, Wehrle JP, Glickson JD. In vivo 31P nuclear magnetic resonance spectroscopy of subcutaneous 9L gliosarcoma: effects of tumor growth and treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea on tumor bioenergetics and histology. Cancer Res. 1988; 48(3): 676-681. PMID 3335030. Tamargo RJ, Epstein JI, Brem H. Heterotransplantation of malignant human gliomas in neonatal rats. J.Neurosurg. 1988; 69(6): 928-933. PMID 3193198. Tamargo RJ, Epstein JI, Reinhard CS, Chasin M, Brem H. Brain biocompatibility of a biodegradable, controlled-release polymer in rats. J.Biomed.Mater.Res. 1989; 23(2): 253-266. PMID 2708412. Brem H, Kader A, Epstein JI, Tamargo RJ, Domb A, Langer R, Leong KW. Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain. Sel.Cancer Ther. 1989; 5(2): 55-65. PMID 2772427. Yang MB, Tamargo RJ, Brem H. Controlled delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea from ethylene-vinyl acetate copolymer. Cancer Res. 1989; 49(18): 5103-5107. PMID 2766281. Salibi SS, Nauta HJ, Brem H, Epstein JI, Cho KR. Lipomeningioma: report of three cases and review of the literature. Neurosurgery. 1989; 25(1): 122-126. PMID 2666878. Langer R, Brem H, Langer LF. New directions in CNS drug delivery. Neurobiol.Aging. 1989; 10(5): 6424; discussion 648-50. PMID 2812246. Steen RG, Tamargo RJ, Brem H, Glickson JD, Wehrle JP. In vivo 31P nuclear magnetic resonance spectroscopy of rat 9L gliosarcoma treated with BCNU: dose response of spectral changes. Magn.Reson.Med. 1989; 11(2): 258-266. PMID 2779416. Levy AP, Tamargo R, Brem H, Nathans D. An endothelial cell growth factor from the mouse neuroblastoma cell line NB41. Growth Factors. 1989; 2(1): 9-19. PMID 2483948. Carson BS and Brem H. Neurological surgery. JAMA. 1990; 263(19): 2658-2659. PMID 2329661. Brem H. Modern treatment of brain tumors. Md.Med.J. 1990; 39(4): 351-354. PMID 2333021. Brem H. Controlled-release polymer systems for drug delivery to the brain. Polymer Preprints. 1990; 31:229. Tamargo RJ, Leong KW, Brem H. Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate. J.Neurooncol. 1990; 9(2): 131-138. PMID 1702149. Guerin C, Laterra J, Hruban RH, Brem H, Drewes LR, Goldstein GW. The glucose transporter and bloodbrain barrier of human brain tumors. Ann.Neurol. 1990; 28(6): 758-765. PMID 2178329. Sills AK, Tamargo RJ, Brem H. Reduction in peritumoral brain edema by an intracranial polymer implant. Surgical Forum. 1990; 41:516-518. Brem H. Polymers to treat brain tumors. Biomaterials. 1990; 11(9): 699-701. PMID 2090306. Chasin M, Hollenbeck G, Brem H, Grossman S, Colvin OM, Langer R. Interstitial drug therapy for brain tumors: A case study. Drug Development and Industrial Pharmacy, 1990; 16(18):2579-2594. Langer LF, Brem H, and Langer R. New technologies for fighting brain disease. Technology Review. 1991; Feb/Mar:63-71. Tamargo RJ, Bok RA, Brem H. Angiogenesis inhibition by minocycline. Cancer Res. 1991; 51(2): 672675. PMID 1702361. Dugan JD,Jr, Lawton MT, Glaser B, Brem H. A new technique for explantation and in vitro cultivation of chicken embryos. Anat.Rec. 1991; 229(1): 125-128. PMID 1996778. Brem H, Mahaley MS,Jr, Vick NA, Black KL, Schold SC,Jr, Burger PC, Friedman AH, Ciric IS, Eller TW, Cozzens JW. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J.Neurosurg. 1991; 74(3): 441-446. PMID 1993909. Capito PR, Wang H, Brem H, Ahn HS, Bryan RN. Magnetic resonance imaging diagnosis of an intracranial metastasis of adenocarcinoma of the prostate: case report. Md.Med.J. 1991; 40(2): 113-115. PMID 1997794. Olivi A, Donehower RC, Mann RB, Brem H. Solitary, isolated metastasis from Ewing's sarcoma to the brain: case report. Surg.Neurol. 1991; 35(3): 239-243. PMID 1996454.

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Tamargo RJ, Sills AK,Jr, Reinhard CS, Pinn ML, Long DM, Brem H. Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema. J.Neurosurg. 1991; 74(6): 956-961. PMID 2033457. Reinhard CS, Radomsky M, Saltzman M, Brem H. Polymeric controlled release of dexamethasone in normal rat brain. J Controlled Release. 1991; 16(3):331-340. Madrid Y, Langer LF, Brem H, Langer R. New directions in the delivery of drugs and other substances to the central nervous system. Adv.Pharmacol. 1991; 22299-324. PMID 1958504. Nabors MW, Griffin CA, Zehnbauer BA, Hruban RH, Phillips PC, Grossman SA, Brem H, Colvin OM. Multidrug resistance gene (MDR1) expression in human brain tumors. J.Neurosurg. 1991; 75(6): 941-946. PMID 1682428. Domb A, Bogdansky S, Olivi A, Judy K, Dureza C, Lenartz D, Pinn ML, Colvin OM, Brem H. Controlled delivery of water soluble and hydrolytically unstable anti-cancer drugs for polymeric implants. Polymer Preprints.1991; 32(2):219-220. Weingart J, Olivi A, and Brem H. Supratentorial low-grade astrocytomas in adults. Neurosurgery Quarterly1991; 1:141-159. Guerin C, Laterra J, Drewes LR, Brem H, Goldstein GW. Vascular expression of glucose transporter in experimental brain neoplasms. Am.J.Pathol. 1992; 140(2): 417-425. PMID 1739134. PMC1886421. Guerin C, Wolff JE, Laterra J, Drewes LR, Brem H, Goldstein GW. Vascular differentiation and glucose transporter expression in rat gliomas: effects of steroids. Ann.Neurol. 1992; 31(5): 481-487. PMID 1596083. Brem H, Domb A, Lenartz D, Dureza C, Olivi A, Epstein JI. Brain biocompatibility of a biodegradable controlled release polymer consisting of anhydride copolymer of fatty acid dimer and sebacic acid. J of Controlled Release. 1992; 19:325-330. Grossman SA, Reinhard C, Colvin OM, Chasin M, Brundrett R, Tamargo RJ, Brem H. The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers. J.Neurosurg. 1992; 76(4): 640-647. PMID 1545259. Griffin CA, Long PP, Carson BS, Brem H. Chromosome abnormalities in low-grade central nervous system tumors. Cancer Genet.Cytogenet. 1992; 60(1): 67-73. PMID 1591709. Phillips SD, Corio RL, Brem H, Mattox D. Ameloblastoma of the mandible with intracranial metastasis. A case study. Arch.Otolaryngol.Head.Neck.Surg. 1992; 118(8): 861-863. PMID 1642839. Brem H. Controlled release polymers to deliver drugs to the brain. Polym. Mater. Sci. Eng.1992 ; 66:85. Guerin C, Laterra J, Masnyk T, Golub LM, Brem H. Selective endothelial growth inhibition by tetracyclines that inhibit collagenase. Biochem.Biophys.Res.Commun. 1992; 188(2): 740-745. PMID 1445318. Buahin KG, Judy KD, Hartke C, Maniar M, Colvin OM, Brem H. Controlled release of 4hydroperoxycyclophosphamide from the fatty acid dimer-sebacic acid copolymer. Polymers For Advanced Technologies. 1992; 3(6):311-316. Tamargo RJ, Brem H. Drug delivery to the central nervous system: A review. Neurosurgery Quarterly. 1992; 2(4):259-279. Weingart J and Brem H. Biology and therapy of glial tumors. Curr.Opin.Neurol.Neurosurg. 1992; 5(6): 808-812. PMID 1467571. Tamargo RJ, Myseros JS, Epstein JI, Yang MB, Chasin M, Brem H. Interstitial chemotherapy of the 9L gliosarcoma: controlled release polymers for drug delivery in the brain. Cancer Res. 1993; 53(2): 329-333. PMID 8417826. Weingart J, Brem H. Current management of high-grade gliomas. Contemporary Oncology. 1993 3(2):1931. Brem H, Walter, KA, Langer R. Polymers as controlled drug delivery devices for the treatment of malignant brain tumors. 1993; Eur. J. Pharm. & Biopharm, 39(1):2-7. Olivi A, Gilbert M, Duncan KL, Corden B, Lenartz D, Brem H. Direct delivery of platinum-based antineoplastics to the central nervous system: a toxicity and ultrastructural study. Cancer Chemother.Pharmacol. 1993; 31(6): 449-454. PMID 8453683. Wolff JE, Guerin C, Laterra J, Bressler J, Indurti RR, Brem H, Goldstein GW. Dexamethasone reduces vascular density and plasminogen activator activity in 9L rat brain tumors. Brain Res. 1993; 604(1-2): 7985. PMID 7681348.

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Zinreich SJ, Tebo SA, Long DM, Brem H, Mattox DE, Loury ME, vander Kolk CA, Koch WM, Kennedy DW, Bryan RN. Frameless stereotaxic integration of CT imaging data: accuracy and initial applications. Radiology. 1993; 188(3): 735-742. PMID 8351341. Olivi A, Kim KD, Benedetti L, Epstein JI, Pinn, ML, Callegaro L, and Brem H. Ocular and brain biocompatibility of polymeric delivery materials prepared from ester derivatives of hyaluronic acid. J of Clinical Materials. 1993; 13:163-168. Brem H, Tamargo RJ, Olivi A, Pinn M, Weingart JD, Wharam M, Epstein JI. Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain. J.Neurosurg. 1994; 80(2): 283-290. PMID 8283268. Phillips PC, Levow C, Catterall M, Colvin OM, Pastan I, Brem H. Transforming growth factor-alphaPseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice. Cancer Res. 1994; 54(4): 1008-1015. PMID 8313355. Wu MP, Tamada JA, Brem H, Langer R. In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy. J.Biomed.Mater.Res. 1994; 28(3): 387-395. PMID 8077254. Cahan MA, Walter KA, Colvin OM, Brem H. Cytotoxicity of taxol in vitro against human and rat malignant brain tumors. Cancer Chemother.Pharmacol. 1994; 33(5): 441-444. PMID 7905792. Walter KA, Cahan MA, Gur A, Tyler B, Hilton J, Colvin OM, Burger PC, Domb A, Brem H. Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma. Cancer Res. 1994; 54(8): 2207-2212. PMID 7909720. Arosarena O, Guerin C, Brem H, Laterra J. Endothelial differentiation in intracerebral and subcutaneous experimental gliomas. Brain Res. 1994; 640(1-2): 98-104. PMID 8004469. Dang W, Colvin OM, Brem H, Saltzman WM. Covalent coupling of methotrexate to dextran enhances the penetration of cytotoxicity into a tissue-like matrix. Cancer Res. 1994; 54(7): 1729-1735. PMID 7511049. Tapper D, Cahan MA, Brem H. Detection of biological activity in the cerebrospinal fluid of patients with central nervous system tumors. J.Neurooncol. 1994; 19(1): 17-23. PMID 7815101. Sipos EP, Tamargo RJ, Weingart JD, Brem H. Inhibition of tumor angiogenesis. Ann.N.Y.Acad.Sci. 1994; 732263-272. PMID 7526758. Griffin CA, Hruban RH, Long PP, Miller N, Volz P, Carson B, Brem H. Chromosome abnormalities in meningeal neoplasms: do they correlate with histology? Cancer Genet.Cytogenet. 1994; 78(1): 46-52. PMID 7987805. Judy KD, Olivi A, Buahin KG, Domb A, Epstein JI, Colvin OM, Brem H. Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas. J.Neurosurg. 1995; 82(3): 481486. PMID 7861228. Weingart JD, Sipos EP, Brem H. The role of minocycline in the treatment of intracranial 9L glioma. J.Neurosurg. 1995; 82(4): 635-640. PMID 7897527. Brem H, Piantadosi S, Burger PC, Walker M, Selker R, Vick NA, Black K, Sisti M, Brem S, Mohr G. Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group. Lancet. 1995; 345(8956): 1008-1012. PMID 7723496. Pressman EK, Zeidman SM, Reddy UM, Epstein JI, Brem H. Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient. J.Reprod.Med. 1995; 40(4): 251-259. PMID 7623353. Weingart JD, Thompson RC, Tyler B, Colvin OM, Brem H. Local delivery of the topoisomerase I inhibitor camptothecin sodium prolongs survival in the rat intracranial 9L gliosarcoma model. Int.J.Cancer. 1995; 62(5): 605-609. PMID 7665233. Sipos EP and Brem H. New delivery systems for brain tumor therapy. Neurol.Clin. 1995; 13(4): 813-825. PMID 8583998. Walter KA, Tamargo RJ, Olivi A, Burger PC, Brem H. Intratumoral chemotherapy. Neurosurgery. 1995; 37(6): 1128-1145. PMID 8584154. Buahin KG and Brem H. Interstitial chemotherapy of experimental brain tumors: comparison of intratumoral injection versus polymeric controlled release. J.Neurooncol. 1995; 26(2): 103-110. PMID 8787852.

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Brem H, Ewend MG, Piantadosi S, Greenhoot J, Burger PC, Sisti M. The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: phase I trial. J.Neurooncol. 1995; 26(2): 111-123. PMID 8787853. Brem H and Langer R. Polymer-based drug delivery to the brain. Scientific American: Science & Medicine. 1996; Vol 3:52-61. Fung LK, Shin M, Tyler B, Brem H, Saltzman WM. Chemotherapeutic drugs released from polymers: distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat brain. Pharm.Res. 1996; 13(5): 671-682. PMID 8860421. Dang W, Daviau T, Brem H. Morphological characterization of polyanhydride biodegradable implant GliadelR during in vitro and in vivo erosion using scanning electron microscopy. Pharmaceutical Research1996; 13(5):683-691. PMID 8860422. Sipos EP, Tebo SA, Zinreich SJ, Long DM, Brem H. In vivo accuracy testing and clinical experience with the ISG Viewing Wand. Neurosurgery. 1996; 39(1): 194-202; discussion 202-4. PMID 8805161. Weingart JD and Brem H. Carmustine implants: Potential in the treatment of brain tumours. CNS Drugs. 1996; (4):263-269. Ewend MG, Anderson R, Tabassi K, Tyler BM, Babel KM, Williams JA, Brem H. Local delivery of BCNU from biodegradable polymer is superior to radiation therapy in treating intracranial melanoma metastases. Surgical Forum. 1996; 47: 564-566. Ewend MG, Carey LA, Brem H. Treatment of melanoma metastases in the brain. Semin.Surg.Oncol. 1996; 12(6): 429-435. PMID 8914207. Ewend MG, Williams JA, Tabassi K, Tyler BM, Babel KM, Anderson RC, Pinn ML, Brat DJ, Brem H. Local delivery of chemotherapy and concurrent external beam radiotherapy prolongs survival in metastatic brain tumor models. Cancer Res. 1996; 56(22): 5217-5223. PMID 8912860. Olivi A, Ewend MG, Utsuki T, Tyler B, Domb AJ, Brat DJ, Brem H. Interstitial delivery of carboplatin via biodegradable polymers is effective against experimental glioma in the rat. Cancer Chemother.Pharmacol. 1996; 39(1-2): 90-96. PMID 8995504. Thompson RC, Pardoll DM, Jaffee EM, Ewend MG, Thomas MC, Tyler BM, Brem H. Systemic and local paracrine cytokine therapies using transduced tumor cells are synergistic in treating intracranial tumors. J.Immunother.Emphasis.Tumor.Immunol. 1996; 19(6): 405-413. PMID 9041459. Utsuki T, Brem H, Pitha J, Loftsson T, Kristmundsdottir T, Tyler BM, Olivi A. Potentiation of anticancer -cyclodextrin. Journal of Controlled Release. 0996; 40:251-260. Sipos EP, Tyler B, Piantadosi S, Burger PC, Brem H. Optimizing interstitial delivery of BCNU from controlled release polymers for the treatment of brain tumors. Cancer Chemother.Pharmacol. 1997; 39(5): 383-389. PMID 9054951. Williams JA, Dillehay LE, Tabassi K, Sipos E, Fahlman C, Brem H. Implantable biodegradable polymers for IUdR radiosensitization of experimental human malignant glioma. J.Neurooncol. 1997; 32(3): 181-192. PMID 9049879. Sampath P, Holliday MJ, Brem H, Niparko JK, Long DM. Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery: etiology and prevention. J.Neurosurg. 1997; 87(1): 60-66. PMID 9202266. Kleinberg L, Slick T, Enger C, Grossman S, Brem H, Wharam MD,Jr. Short course radiotherapy is an appropriate option for most malignant glioma patients. Int.J.Radiat.Oncol.Biol.Phys. 1997; 38(1): 31-36. PMID 9212001. Perry JR, DeAngelis LM, Schold SC,Jr, Burger PC, Brem H, Brown MT, Curran WJ, Scott CB, Prados MD, Kaplan R, Cairncross JG. Challenges in the design and conduct of phase III brain tumor therapy trials. Neurology. 1997; 49(4): 912-917. PMID 9339667. Bohan E, Brem H. Treatment of brain tumors by local delivery of chemotherapy via biodegradable polymers. Hospital Pharmacist Report. 1997; 12:12-18. Fung LK, Ewend MG, Sills A, Sipos EP, Thompson R, Watts M, Colvin OM, Brem H, Saltzman WM. Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide, and paclitaxel from a biodegradable polymer implant in the monkey brain. Cancer Res. 1998; 58(4): 672-684. PMID 9485020.

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Cardinale RM, Dillehay LE, Williams JA, Tabassi K, Brem H, Lee DJ. Effect of interstitial and/or systemic delivery of tirapazamine on the radiosensitivity of human glioblastoma multiforme in nude mice. Radiat.Oncol.Investig. 1998; 6(2): 63-70. PMID 9572682. Grossman SA, Fisher JD, Piantadosi S, Brem H. The New Approaches to Brain Tumor Therapy (NABTT) CNS Consortium: Organization, Objectives, and Activities. Cancer Control. 1998; 5(2): 107-114. PMID 10761021. Sampath P and Brem H. Implantable Slow-Release Chemotherapeutic Polymers for the Treatment of Malignant Brain Tumors. Cancer Control. 1998; 5(2): 130-137. PMID 10761024. Wiranowska M, Ransohoff J, Weingart JD, Phelps C, Phuphanich S, Brem H. Interferon-containing controlled-release polymers for localized cerebral immunotherapy. J.Interferon Cytokine Res. 1998; 18(6): 377-385. PMID 9660244. Sills AK,Jr, Williams JI, Tyler BM, Epstein DS, Sipos EP, Davis JD, McLane MP, Pitchford S, Cheshire K, Gannon FH, Kinney WA, Chao TL, Donowitz M, Laterra J, Zasloff M, Brem H. Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature. Cancer Res. 1998; 58(13): 2784-2792. PMID 9661892. Posner GH, Lee JK, Wang Q, Peleg S, Burke M, Brem H, Dolan P, Kensler TW. Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25dihydroxyvitamin D3. Synthesis and preliminary biological evaluation. J.Med.Chem. 1998; 41(16): 30083014. PMID 9685240. Ewend MG, Sampath P, Williams JA, Tyler BM, Brem H. Local delivery of chemotherapy prolongs survival in experimental brain metastases from breast carcinoma. Neurosurgery. 1998; 43(5): 1185-1193. PMID 9802862. Sampath P, Rhines LD, Holliday MJ, Brem H, Long DM. Late-onset facial nerve degeneration after vestibular schwannoma surgery: incidence, putative mechanisms, and prevention. Neurosurg.Focus. 1998; 5(3): e6. PMID 17112221. Chou D, Sampath P, Brem H. Hemorrhagic vestibular schwannoma: an unusual clinical entity. Case report. Neurosurg.Focus. 1998; 5(3): e9. PMID 17112224. Williams JA, Yuan X, Dillehay LE, Shastri VR, Brem H, Williams JR. Synthetic, implantable polymers for local delivery of IUdR to experimental human malignant glioma. Int.J.Radiat.Oncol.Biol.Phys. 1998; 42(3): 631-639. PMID 9806525. Williams J, Enger C, Wharam M, Tsai D, Brem H. Stereotactic radiosurgery for brain metastases: comparison of lung carcinoma vs. non-lung tumors. J.Neurooncol. 1998; 37(1): 79-85. PMID 9525842. Sampath P, Hanes J, DiMeco F, Tyler BM, Brat D, Pardoll DM, Brem H. Paracrine immunotherapy with interleukin-2 and local chemotherapy is synergistic in the treatment of experimental brain tumors. Cancer Res. 1999; 59(9): 2107-2114. PMID 10232596. Brem H and Lawson HC. The development of new brain tumor therapy utilizing the local and sustained delivery of chemotherapeutic agents from biodegradable polymers. Cancer. 1999; 86(2): 197-199. PMID 10421254. Posner GH, Wang Q, Han G, Lee JK, Crawford K, Zand S, Brem H, Peleg S, Dolan P, Kensler TW. Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation. J.Med.Chem. 1999; 42(18): 3425-3435. PMID 10479276. Suh KW, Piantadosi S, Yazdi HA, Pardoll DM, Brem H, Choti MA. Treatment of liver metastases from colon carcinoma with autologous tumor vaccine expressing granulocyte-macrophage colony-stimulating factor. J.Surg.Oncol. 1999; 72(4): 218-224. PMID 10589037. Sampath P, Long DM, Brem H. The Hunterian Neurosurgical Laboratory: the first 100 years of neurosurgical research. Neurosurgery. 2000; 46(1): 184-94; discussion 194-5. PMID 10626949. DiMeco F, Rhines LD, Hanes J, Tyler BM, Brat D, Torchiana E, Guarnieri M, Colombo MP, Pardoll DM, Finocchiaro G, Brem H, Olivi A. Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats. J.Neurosurg. 2000; 92(3): 419-427. PMID 10701528. Haroun RI, Lee KW, Carson BS, Brem H. Primary tumors of the choroids plexus. Contemporary Neurosurgery. 2000; 2(3). Haroun RI and Brem H. Local drug delivery. Curr.Opin.Oncol. 2000; 12(3): 187-193. PMID 10841189. Klink DF, Sampath P, Miller NR, Brem H, Long DM. Long-term visual outcome after nonradical microsurgery patients with parasellar and cavernous sinus meningiomas. Neurosurgery. 2000; 47(1): 24-31; discussion 31-2. PMID 10917343.

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118. Ewend MG, Thompson RC, Anderson R, Sills AK, Staveley-O'Carroll K, Tyler BM, Hanes J, Brat D, Thomas M, Jaffee EM, Pardoll DM, Brem H. Intracranial paracrine interleukin-2 therapy stimulates prolonged antitumor immunity that extends outside the central nervous system. J.Immunother. 2000; 23(4): 438-448. PMID 10916753. 119. Rhines LD, Sampath P, Dolan ME, Tyler BM, Brem H, Weingart J. O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma. Cancer Res. 2000; 60(22): 6307-6310. PMID 11103789. 120. Sipos EP and Brem H. Local anti-angiogenic brain tumor therapies. J.Neurooncol. 2000; 50(1-2): 181-188. PMID 11245278. 121. Olivi A, DiMeco F, Bohan E, Brem H. Developing new methods for the treatment of malignant brain tumours: local delivery of anti-neoplastic agents using biodegradable polymers. Forum.(Genova). 2000; 10(2): 152-165. PMID 10875976. 122. Sipos EP, Witham TF, Ratan R, Burger PC, Baraban J, Li KW, Piantadosi S, Brem H. L-buthionine sulfoximine potentiates the antitumor effect of 4-hydroperoxycyclophosphamide when administered locally in a rat glioma model. Neurosurgery. 2001; 48(2): 392-400. PMID 11220384. 123. Conway JE, Chou D, Clatterbuck RE, Brem H, Long DM, Rigamonti D. Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease. Neurosurgery. 2001; 48(1): 55-62; discussion 62-3. PMID 11152361. 124. Lesniak MS, Sampath P, DiMeco F, Viglione MP, Tyler BM, Pardoll DM, Brem H. Comparative analysis of paracrine immunotherapy in experimental brain tumors. Neurosurg.Focus. 2000; 9(6): e4. PMID 16817687. 125. Lesniak MS, Langer R, Brem H. Drug delivery to tumors of the central nervous system. Curr.Neurol.Neurosci.Rep. 2001; 1(3): 210-216. PMID 11898520. 126. White MC, Burke MD, Peleg S, Brem H, Posner GH. Conformationally restricted hybrid analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): design, synthesis, and biological evaluation. Bioorg.Med.Chem. 2001; 9(7): 1691-1699. PMID 11425569. 127. Brem H and Gabikian P. Biodegradable polymer implants to treat brain tumors. J.Control.Release. 2001; 74(1-3): 63-67. PMID 11489483. 128. Hanes J, Sills A, Zhao Z, Suh KW, Tyler B, DiMeco F, Brat DJ, Choti MA, Leong KW, Pardoll DM, Brem H. Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors. Pharm.Res. 2001; 18(7): 899-906. PMID 11496947. 129. Rothstein JD and Brem H. Excitotoxic destruction facilitates brain tumor growth. Nat.Med. 2001; 7(9): 994-995. PMID 11533696. 130. Reavey-Cantwell JF, Haroun RI, Zahurak M, Clatterbuck RE, Parker RJ, Mehta R, Fruehauf JP, Brem H. The prognostic value of tumor markers in patients with glioblastoma multiforme: analysis of 32 patients and review of the literature. J.Neurooncol. 2001; 55(3): 195-204. PMID 11859975. 131. Freitag SK, Miller NR, Brem H. Recurrent ectopic craniopharyngioma. Br.J.Neurosurg. 2001; 15(6): 511513. PMID 11814004. 132. Kaminski JM, Movsas B, King E, Yang C, Kronz JD, Alli PM, Williams J, Brem H. Metastatic meningioma to the lung with multiple pleural metastases. Am.J.Clin.Oncol. 2001; 24(6): 579-582. PMID 11801758. 133. Mori S, Kraut MA, Van Zul PC,Solaiyappa M, Brem H, Pomer M. Diffusion tensor imaging and fiber tracking of brain tumors. Proceedings of the International Society of Magnetic Resonance in Medicine. 2001 ; 9:507. 134. Liu JM, Garonzik IM, Eberhart CG, Sampath P, Brem H. Ectopic recurrence of craniopharyngioma after an interhemispheric transcallosal approach: case report. Neurosurgery. 2002; 50(3): 639-44; discussion 644-5. PMID 11841735. 135. Storm PB, Moriarity JL, Tyler B, Burger PC, Brem H, Weingart J. Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy. J.Neurooncol. 2002; 56(3): 209-217. PMID 12061726. 136. Haroun RI, Clatterbuck RE, Gibbons MC, Burger PC, Parker R, Fruehauf JP, Brem H. Extreme drug resistance in primary brain tumors: in vitro analysis of 64 resection specimens. J.Neurooncol. 2002; 58(2): 115-123. PMID 12164682.

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137. Toung TJ, Tyler B, Brem H, Traystman RJ, Hurn PD, Bhardwaj A. Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor. J.Neurosurg.Anesthesiol. 2002; 14(3): 187-193. PMID 12172290. 138. DiMeco F, Li KW, Tyler BM, Wolf AS, Brem H, Olivi A. Local delivery of mitoxantrone for the treatment of malignant brain tumors in rats. J.Neurosurg. 2002; 97(5): 1173-1178. PMID 12450040. 139. Wang PP, Frazier J, Brem H. Local drug delivery to the brain. Adv.Drug Deliv.Rev. 2002; 54(7): 9871013. PMID 12384318. 140. Lugassy C, Haroun RI, Brem H, Tyler BM, Jones RV, Fernandez PM, Patierno SR, Kleinman HK, Barnhill RL. Pericytic-like angiotropism of glioma and melanoma cells. Am.J.Dermatopathol. 2002; 24(6): 473-478. PMID 12454598. 141. Sampath P, Amundson E, Wall ME, Tyler BM, Wani MC, Alderson LM, Colvin M, Brem H, Weingart JD. Camptothecin analogs in malignant gliomas: comparative analysis and characterization. J.Neurosurg. 2003; 98(3): 570-577. PMID 12650430. 142. Rhines LD, Sampath P, DiMeco F, Lawson HC, Tyler BM, Hanes J, Olivi A, Brem H. Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma. Neurosurgery. 2003; 52(4): 872-9; discussion 879-80. PMID 12657184. 143. Long DM, Gordon T, Bowman H, Etzel A, Burleyson G, Betchen S, Garonzik IM, Brem H. Outcome and cost of craniotomy performed to treat tumors in regional academic referral centers. Neurosurgery. 2003; 52(5): 1056-63; discussion 1063-5. PMID 12699547. 144. Hammoud DA, Belden CJ, Ho AC, Dal Pan GJ, Herskovits EH, Hilt DC, Brem H, Pomper MG. The surgical bed after BCNU polymer wafer placement for recurrent glioma: serial assessment on CT and MR imaging. AJR Am.J.Roentgenol. 2003; 180(5): 1469-1475. PMID 12704070. 145. Legnani FG, Pradilla G, Wang PP, Brem H, Olivi A, Dimeco F. Local delivery of antineoplastic agents using biodegradable polymers for the treatment of malignant brain tumors. Expert Rev.Neurother. 2003; 3(4): 533-546. PMID 19810937. 146. Lesniak MS, Tyler BM, Pardoll DM, Brem H. Gene therapy for experimental brain tumors using a xenogenic cell line engineered to secrete hIL-2. J.Neurooncol. 2003; 64(1-2): 155-160. PMID 12952296. 147. Chang SM, Parney IF, McDermott M, Barker FG,2nd, Schmidt MH, Huang W, Laws ER,Jr, Lillehei KO, Bernstein M, Brem H, Sloan AE, Berger M, Glioma Outcomes Investigators. Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project. J.Neurosurg. 2003; 98(6): 1175-1181. PMID 12816260. 148. Laws ER, Parney IF, Huang W, Anderson F, Morris AM, Asher A, Lillehei KO, Bernstein M, Brem H, Sloan A, Berger MS, Chang S, Glioma Outcomes Investigators. Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. J.Neurosurg. 2003; 99(3): 467-473. PMID 12959431. 149. Li KW, Dang W, Tyler BM, Troiano G, Tihan T, Brem H, Walter KA. Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies. Clin.Cancer Res. 2003; 9(9): 3441-3447. PMID 12960135. 150. Pradilla G, Azzam T, Wang PP, Domb AJ, Brem H. Gene therapy for malignant brain tumors. Expert Rev.Neurother. 2003; 3(5): 685-701. PMID 19810968. 151. Brem H and Amundson E. Preparing Hopkins medical students for a career in academic neurosurgery. Surgery. 2003; 134(3): 414-415. PMID 14555924. 152. Frazier JL, Wang PP, Case D, Tyler BM, Pradilla G, Weingart JD, Brem H. Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma. J.Neurooncol. 2003; 64(3): 203-209. PMID 14558595. 153. Richards Grayson AC, Choi IS, Tyler BM, Wang PP, Brem H, Cima MJ, Langer R. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat.Mater. 2003; 2(11): 767-772. PMID 14619935. 154. Moses MA, Brem H, Langer R. Advancing the field of drug delivery: taking aim at cancer. Cancer.Cell. 2003; 4(5): 337-341. PMID 14667500. 155. Guerin C, Olivi A, Weingart JD, Lawson HC, Brem H. Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. Invest.New Drugs. 2004; 22(1): 27-37. PMID 14707492. 156. Komotar RJ, Burger PC, Carson BS, Brem H, Olivi A, Goldthwaite PT, Tihan T. Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas. Neurosurgery. 2004; 54(1): 72-9; discussion 79-80. PMID 14683543. Updated 10/26/2015

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157. Samdani AF, Kuchner EB, Rhines L, Adamson DC, Lawson C, Tyler B, Brem H, Dawson VL, Dawson TM. Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo. Neurosurgery. 2004; 54(5): 1231-7; discussion 1237-8. PMID 15113479. 158. Kleinberg LR, Weingart J, Burger P, Carson K, Grossman SA, Li K, Olivi A, Wharam MD, Brem H. Clinical course and pathologic findings after Gliadel and radiotherapy for newly diagnosed malignant glioma: implications for patient management. Cancer Invest. 2004; 22(1): 1-9. PMID 15069758. 159. Lesniak MS and Brem H. Targeted therapy for brain tumours. Nat.Rev.Drug Discov. 2004; 3(6): 499-508. PMID 15173839. 160. Basaria S, Westra WH, Brem H, Salvatori R. Metastatic renal cell carcinoma to the pituitary presenting with hyperprolactinemia. J.Endocrinol.Invest. 2004; 27(5): 471-474. PMID 15279082. 161. Storm PB, Renard VM, Moriarity JL, Tyler B, Wilentz RE, Brem H, Weingart JD. Systemic BCNU enhances the efficacy of local delivery of a topoisomerase I inhibitor against malignant glioma. Cancer Chemother.Pharmacol. 2004; 54(4): 361-367. PMID 15197484. 162. Lesniak MS, Gabikian P, Tyler BM, Pardoll DM, Brem H. Dexamethasone mediated inhibition of local IL2 immunotherapy is dose dependent in experimental brain tumors. J.Neurooncol. 2004; 70(1): 23-28. PMID 15527103. 163. Moses MA, Brem H, Langer R. Novel delivery systems in cancer chemotherapy. Sci & Med, 9(5):264273, 2003 [published July 2004]. 164. Li Y, Shawgo RS, Tyler B, Henderson PT, Vogel JS, Rosenberg A, Storm PB, Langer R, Brem H, Cima MJ. In vivo release from a drug delivery MEMS device. J.Control.Release. 2004; 100(2): 211-219. PMID 15544869. 165. Chang SM, Parney IF, Huang W, Anderson FA,Jr, Asher AL, Bernstein M, Lillehei KO, Brem H, Berger MS, Laws ER, Glioma Outcomes Project Investigators. Patterns of care for adults with newly diagnosed malignant glioma. JAMA. 2005; 293(5): 557-564. PMID 15687310. 166. Koenig MA, Geocadin RG, Kulesza P, Olivi A, Brem H. Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report. J.Neurosurg. 2005; 102(2): 371-375. PMID 15739568. 167. Mantha A, Legnani FG, Bagley CA, Gallia GL, Garonzik I, Pradilla G, Amundson E, Tyler BM, Brem H, Gokaslan ZL. A novel rat model for the study of intraosseous metastatic spine cancer. J.Neurosurg.Spine. 2005; 2(3): 303-307. PMID 15796355. 168. Raza SM, Pradilla G, Legnani FG, Thai QA, Olivi A, Weingart JD, Brem H. Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours. Expert Opin.Biol.Ther. 2005; 5(4): 477-494. PMID 15934827. 169. Mavinkurve G, Pradilla G, Legnani FG, Tyler BM, Bagley CA, Brem H, Jallo G. A novel intramedullary spinal cord tumor model: functional, radiological, and histopathological characterization. J.Neurosurg.Spine. 2005; 3(2): 142-148. PMID 16370303. 170. Gallia GL, Brem S, Brem H. Local treatment of malignant brain tumors using implantable chemotherapeutic polymers. J.Natl.Compr.Canc Netw. 2005; 3(5): 721-728. PMID 16194460. 171. Hsu W, Lesniak MS, Tyler B, Brem H. Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma. J.Neurooncol. 2005; 74(2): 135-140. PMID 16193383. 172. Lesniak MS, Upadhyay U, Goodwin R, Tyler B, Brem H. Local delivery of doxorubicin for the treatment of malignant brain tumors in rats. Anticancer Res. 2005; 25(6B): 3825-3831. PMID 16312042. PMC1635000. 173. Pradilla G, Legnani FG, Petrangolini G, Francescato P, Chillemi F, Tyler BM, Gaini SM, Brem H, Olivi A, DiMeco F. Local delivery of a synthetic endostatin fragment for the treatment of experimental gliomas. Neurosurgery. 2005; 57(5): 1032-40; discussion 1032-40. PMID 16284573. PMC1635009. 174. Li Y, Ho Duc HL, Tyler B, Williams T, Tupper M, Langer R, Brem H, Cima MJ. In vivo delivery of BCNU from a MEMS device to a tumor model. J.Control.Release. 2005; 106(1-2): 138-145. PMID 16167384. 175. Quinn JA, Desjardins A, Weingart J, Brem H, Dolan ME, Delaney SM, Vredenburgh J, Rich J, Friedman AH, Reardon DA, Sampson JH, Pegg AE, Moschel RC, Birch R, McLendon RE, Provenzale JM, Gururangan S, Dancey JE, Maxwell J, Tourt-Uhlig S, Herndon JE,2nd, Bigner DD, Friedman HS. Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J.Clin.Oncol. 2005; 23(28): 7178-7187. PMID 16192602.

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176. Brem SS, Bierman PJ, Black P, Blumenthal DT, Brem H, Chamberlain MC, Chiocca EA, DeAngelis LM, Fenstermaker RA, Fine HA, Friedman A, Glass J, Grossman SA, Heimberger AB, Junck L, Levin V, Loeffler JJ, Maor MH, Narayana A, Newton HB, Olivi A, Portnow J, Prados M, Raizer JJ, Rosenfeld SS, Shrieve DC, Sills AK,Jr, Spence AM, Vrionis FD, National Comprehensive Cancer Network. Central nervous system cancers: Clinical Practice Guidelines in Oncology. J.Natl.Compr.Canc Netw. 2005; 3(5): 644-690. PMID 16194456. 177. Pradilla G, Wang PP, Gabikian P, Li K, Magee CA, Walter KA, Brem H. Local intracerebral administration of Paclitaxel with the paclimer delivery system: toxicity study in a canine model. J.Neurooncol. 2006; 76(2): 131-138. PMID 16284923. PMC1635008. 178. Legnani FG, Pradilla G, Thai QA, Fiorindi A, Recinos PF, Tyler BM, Gaini SM, DiMeco F, Brem H, Olivi A. Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. J.Neurooncol. 2006; 77(3): 225-232. PMID 16609837. PMC1635004. 179. Caplan J, Pradilla G, Hdeib A, Tyler BM, Legnani FG, Bagley CA, Brem H, Jallo G. A novel model of intramedullary spinal cord tumors in rats: functional progression and histopathological characterization. Neurosurgery. 2006; 59(1): 193-200; discussion 193-200. PMID 16823316. 180. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F, Vescovi AL. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumourinitiating cells. Nature. 2006; 444(7120): 761-765. PMID 17151667. 181. Sampath P, Rhines LD, DiMeco F, Tyler BM, Park MC, Brem H. Interstitial docetaxel (taxotere), carmustine and combined interstitial therapy: a novel treatment for experimental malignant glioma. J.Neurooncol. 2006; 80(1): 9-17. PMID 16636748. PMC1780249. 182. Fruehauf JP, Brem H, Brem S, Sloan A, Barger G, Huang W, Parker R. In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. Clin.Cancer Res. 2006; 12(15): 4523-4532. PMID 16899598. 183. Lawson HC, Sampath P, Bohan E, Park MC, Hussain N, Olivi A, Weingart J, Kleinberg L, Brem H. Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience. J.Neurooncol. 2007; 83(1): 61-70. PMID 17171441. 184. Bookland MJ, Bagley CA, Schwarz J, Burger PC, Brem H. Intracavernous trigeminal ganglion amyloidoma: case report. Neurosurgery. 2007; 60(3): E574; discussion E574. PMID 17327767. 185. Michaels RK, Makary MA, Dahab Y, Frassica FJ, Heitmiller E, Rowen LC, Crotreau R, Brem H, Pronovost PJ. Achieving the National Quality Forum's "Never Events": prevention of wrong site, wrong procedure, and wrong patient operations. Ann.Surg. 2007; 245(4): 526-532. PMID 17414599. PMC1877039. 186. Kominsky SL, Tyler B, Sosnowski J, Brady K, Doucet M, Nell D, Smedley JG,3rd, McClane B, Brem H, Sukumar S. Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis. Cancer Res. 2007; 67(17): 7977-7982. PMID 17804705. 187. Marupudi NI, Han JE, Li KW, Renard VM, Tyler BM, Brem H. Paclitaxel: a review of adverse toxicities and novel delivery strategies. Expert Opin.Drug Saf. 2007; 6(5): 609-621. PMID 17877447. 188. Brem S, Tyler B, Li K, Pradilla G, Legnani F, Caplan J, Brem H. Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model. Cancer Chemother.Pharmacol. 2007; 60(5): 643-650. PMID 17256133. 189. Chaichana KL, Capilla-Gonzalez V, Gonzalez-Perez O, Pradilla G, Han J, Olivi A, Brem H, GarciaVerdugo JM, Quinones-Hinojosa A. Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. J.Neurosci.Methods. 2007; 164(2): 261-270. PMID 17580092. PMC2744592. 190. Baird CJ, Hdeib A, Suk I, Francis HW, Holliday MJ, Tamargo RJ, Brem H, Long DM. Reduction of cerebrospinal fluid rhinorrhea after vestibular schwannoma surgery by reconstruction of the drilled porus acusticus with hydroxyapatite bone cement. J.Neurosurg. 2007; 107(2): 347-351. PMID 17695389. 191. Kim GY, Tyler BM, Tupper MM, Karp JM, Langer RS, Brem H, Cima MJ. Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model. J.Control.Release. 2007; 123(2): 172-178. PMID 17884232. 192. Sonabend AM, Velicu S, Ulasov IV, Han Y, Tyler B, Brem H, Matar MM, Fewell JG, Anwer K, Lesniak MS. A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma. Anticancer Drugs. 2008; 19(2): 133-142. PMID 18176109. Updated 10/26/2015

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193. Brem SS, Bierman PJ, Black P, Brem H, Chamberlain MC, Chiocca EA, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Glass J, Grossman SA, Heimberger AB, Junck L, Linette GP, Loeffler JJ, Maor MH, Moots P, Mrugala M, Nabors LB, Newton HB, Olivi A, Portnow J, Prados M, Raizer JJ, Shrieve DC, Sills AK,Jr. Central nervous system cancers. J.Natl.Compr.Canc Netw. 2008; 6(5): 456-504. PMID 18492461. 194. Gathinji M, McGirt MJ, Attenello FJ, Chaichana KL, Than K, Olivi A, Weingart JD, Brem H, QuinonesHinojosa A. Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surg.Neurol. 2009; 71(3): 299-303, discussion 303. PMID 18786716. 195. Attenello FJ, Mukherjee D, Datoo G, McGirt MJ, Bohan E, Weingart JD, Olivi A, Quinones-Hinojosa A, Brem H. Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience. Ann.Surg.Oncol. 2008; 15(10): 2887-2893. PMID 18636295. 196. McGirt MJ, Chaichana KL, Attenello FJ, Weingart JD, Than K, Burger PC, Olivi A, Brem H, QuinonesHinojosa A. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. 2008; 63(4): 700-7; author reply 707-8. PMID 18981880. 197. Gallia GL, Tyler BM, Hann CL, Siu IM, Giranda VL, Vescovi AL, Brem H, Riggins GJ. Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Mol.Cancer.Ther. 2009; 8(2): 386-393. PMID 19208828. 198. McGirt MJ, Than KD, Weingart JD, Chaichana KL, Attenello FJ, Olivi A, Laterra J, Kleinberg LR, Grossman SA, Brem H, Quinones-Hinojosa A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. J.Neurosurg. 2009; 110(3): 583-588. PMID 19046047. 199. McGirt MJ, Chaichana KL, Gathinji M, Attenello FJ, Than K, Olivi A, Weingart JD, Brem H, QuinonesHinojosa AR. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. J.Neurosurg. 2009; 110(1): 156-162. PMID 18847342. 200. Chaichana KL, McGirt MJ, Woodworth GF, Datoo G, Tamargo RJ, Weingart J, Olivi A, Brem H, Quinones-Hinojosa A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurol.Res. 2010; 32(4):442-8. PMID 19589201. 201. Slager J, Tyler B, Shikanov A, Domb AJ, Shogen K, Sidransky D, Brem H. Local controlled delivery of anti-neoplastic RNAse to the brain. Pharm.Res. 2009; 26(8): 1838-1846. PMID 19415468. 202. Recinos VR, Bekelis K, Ziegler SG, Vick D, Hertig S, Tyler BM, Li KW, Kosztowski T, Legnani FG, Brem H, Olivi A. Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. J.Neurooncol. 2010; 97(1): 1-10. PMID 19693439. 203. de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J.Clin.Neurosci. 2009; 16(9): 1246-1249. PMID 19560362. 204. Recinos VR, Tyler BM, Bekelis K, Sunshine SB, Vellimana A, Li KW, Brem H. Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model. Neurosurgery. 2010; 66(3): 530-7; discussion 537. PMID 20173548. 205. Tyler B, Fowers KD, Li KW, Recinos VR, Caplan JM, Hdeib A, Grossman R, Basaldella L, Bekelis K, Pradilla G, Legnani F, Brem H. A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats. J.Neurosurg. 2010; 113(2):210-7; PMID 20001591. 206. Mukherjee D, Zaidi HA, Kosztowski T, Chaichana KL, Brem H, Chang DC, Quinones-Hinojosa A. Disparities in Access to Neuro-oncologic Care in the United States. Arch.Surg. 2010; 145(3): 247-253. PMID 20231625. 207. Chaichana KL, Kosztowski T, Niranjan A, Olivi A, Weingart JD, Laterra J, Brem H, Quinones-Hinojosa A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. J.Neurosurg. 2010; 113(2):286-92 PMID 20302391. 208. McGirt MJ, Brem H. Carmustine wafers (Gliadel) plus concomitant temozolomide therapy after resection of malignant astrocytomas: growing evidence for safety and efficacy. Ann Surg Oncol. 2010;17(7):1729-31. PMID: 20422453 209. Grossman R, Mukherjee D, Chaichana KL, Salvatori R, Wand G, Brem H, Chang DC, Quiñones-Hinojosa A. Complications and Death Among Elderly Patients Undergoing Pituitary Tumor Surgery. Clin Endocrinol. 2010; Sep;73(3):361-8 PMID: 20455889 Updated 10/26/2015

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210. Chaichana KL, Halthore AN, Parker SL, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa A. Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. J Neurosurg. 2011; 114(3):604-12. PMID: 20524825 211. Chaichana KL, Garzon-Muvdi T, Parker S, Weingart JD, Olivi A, Bennett R, Brem H, Quiñones-Hinojosa A. Supratentorial Glioblastoma Multiforme: The Role of Surgical Resection Versus Biopsy Among Older Patients. Ann Surg Oncol. 2011; 18(1):239-45. PMID: 20697823 212. Raza SM, Gallia GL, Brem H, Weingart JD, Long DM, Olivi A. Perioperative and long-term outcomes from the management of parasagittal meningiomas invading the superior sagittal sinus. Neurosurgery. 2010; 67(4): 885-93; discussion 893. PMID 20802356 213. Grossman R, Mukherjee D, Chang DC, Purtell M, Lim M, Brem H, Quiñones-Hinojosa A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Ann Surg Oncol. 2011; 18(2):521-8. PMID: 20809176 214. Chaichana KL, Chaichana KK, Olivi A, Weingart JD, Bennett R, Brem H, Quiñones-Hinojosa A. Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. J Neurosurg. 2011;114(3):587-94. PMID: 20887095. 215. Scott AW, Tyler BM, Masi BC, Upadhyay UM, Patta YR, Grossman R, Basaldella L, Langer RS, Brem H, Cima MJ. Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model. Biomaterials. 2011; 32(10):2532-9. PMID: 21220172 216. Latimer K, Pendleton C, Olivi A, Cohen-Gadol AA, Brem H, Quiñones-Hinojosa A. Harvey Cushing’s Open and Thorough Documentation of Surgical Mishaps at the Dawn of Neurological Surgery. Arch Surg. 2011;146 (2):226-32. PMID: 21339437 217. Grossman R, Mukherjee D, Chang DC, Bennett R, Brem H, Olivi A, Quiñones-Hinojosa A. Preoperative charlson comorbidity score predicts postoperative outcomes among older intracranial meningioma patients. World Neurosurg. 2011;75(2):279-85. PMID: 21492731 218. Brem SS, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Chiocca EA, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Junck L, Linette GP, Loeffler JS, Maor MH, Michael M, Moots PL, Morrison T, Mrugala M, Nabors LB, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK Jr, Vrionis FD, Wen PY. Central Nervous System Cancers. J Natl Compr Canc Netw. 2011;9(4):352-400. PMID: 21464114 219. Tyler B, Wadsworth S, Recinos V, Mehta V, Vellimana A, Li K, Rosenblatt J, Do H, Gallia GL, Siu IM, Wicks RT, Rudek MA, Zhao M, Brem H. Local delivery of rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats. Neuro Oncol. 2011;13(7):700-9. PMID:21727209 220. Chaichana KL, Zaidi H, Pendleton C, McGirt MJ, Grossman R, Weingart JD, Olivi A, Quiñones-Hinojosa A, Brem H. The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival. Neurol Res. 2011;33(7):759-64. PMID: 21756557 221. Grossman R, Tyler B, Hwang L, Zadnik P, Lal, B, Javaherian K, Brem H. Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin. J. Neurosurg. 2011;115(6):1139-46. PMID: 21923243. 222. Tyler BM, Hdeib A, Caplan J, Legnani FG, Fowers KD, Brem H, Jallo G, Pradilla G . Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel. J Neurosurg Spine . 2012;16(1):93-101 PMID:22208429. 223. Masi BC, Tyler BM, Bow H, Wicks RT, Xue Y, Brem H, Langer R, Cima MJ. Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. Biomaterials. 2012;33(23):5768-75. PMID:22591609. 224. Link TW, Woodworth GF, Chaichana KL, Grossman SA, Mayer RS, Brem H, Weingart JD, QuinonesHinojosa A. Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma. J Clin Neurosci. 2012;19(7):966-1000. PMID:22595358. 225. Grossman R, Rudek MA, Brastianos H, Zadnik P, Brem H, Tyler B, Blakeley JO. The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas. Cancer Chemother Pharmacol. 2012; 70(1):129-39. PMID: 22644796. 226. Chaichana KL, Jackson C, Patel A, Miller N, Subramanian P, Olivi A, Lim M, Gallia GL, Weingart JD, Brem H, Quiñones-Hinojosa A. Predictors of visual outcome following surgical resection of medial sphenoid wing meningiomas. J Neurol Surg B Skull Base 2012 Oct;73(5):321-6. PMC3578636.

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227. Kong S, Senqupta S, Tyler BM, Ma Q, Doucette S, Zhou J, Sahin A, Carter B, Brem H, Junghans RP, Sampath P. Supression of Human Glioma Xenografts with 2nd Generation IL13R-Specific Chimeric Antigen receptor-Modified T Cells. Clin Cancer Res. 2012;18(21):5949-5960. 228. Grossman R, Tyler B, Brem H, Eberhart CG, Wand S, Fu DX, Wen Z, Zhou J. Growth properties of SF 188/V+ human glioma in rats observed by magnetic resonance imaging. J Neurooncol. 2012; 110(3):31523. PMC3500409. 229. Pendleton C, Olivi A, Brem H, Quiñones-Hinojosa A. Harvey Cushing's early treatment of meningiomas: the untold story. World Neurosurg. 2013 Jul-Aug;80(1-2):217-21. Epub 2011 Nov 7. PubMed PMID: 22120300 230. Chaichana KL, Pendleton C, Zaidi H, Olivi A, Weingart JD, Gallia GL, Lim M, Brem H, QuiñonesHinojosa A. Seizure control for patients undergoing meningioma surgery. World Neurosurg. 2013 MarApr;79(3-4):515-24. Epub 2012 Mar 30. PubMed PMID: 22469524. 231. Chaichana KL, Zadnik P, Weingart JD, Olivi A, Gallia GL, Blakeley J, Lim M, Brem H, Quiñones Hinojosa A. Multiple resections for patients with glioblastoma: prolonging survival. J Neurosurg. 2013;118(4):812-20. PMC3700339. 232. Vellimana AK, Recinos VR, Hwang L, Fowers KD, Li KW, Zhang Y, Okonma S, Eberhart CG, Brem H, Tyler BM. Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model. J Neurooncol. 2013 Feb;111(3):229-36 Epub 2012 Dec 7. PMID: 23224713: PMC4029109. 233. Chaichana KL, Pendleton C, Jackson C, Martinez-Gutierrez J, Diaz-Stransky A, Aguayo J, Olivi A, Weingart J, Gallia GL, Lim M, Brem H, Quiñones-Hinojosa A: Deep vein thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors. . Neurol Res. 2013 Mar;35(2):206-11.. Epub 2012 Dec 13. PMID: 23336127; PMC3991124. 234. Jackson C, Ruzevick J, Brem H, Lim M. Vaccine strategies for glioblastoma: progress and future directions. Immunotherapy. 2013 Feb;5(2):155-67.. Review. PMID: 23413907;:PMC4086484. 235. Zeng J, See A, Phallen J, Jackson CM, Belcaid Z, Ruzevick J, Durham N, Meyer C, Harris TJ, Albesiano E, Pradilla G, Ford E, Wong J, Hammers H, Mathios D, Tyler BM, Brem H, Tran PT, Pardoll D, Drake CG, Lim M. Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas. Int J Radiat Oncol Biol Phys. 2013 Jun 1;86(2):343-9. Epub 2013 Feb 22. PMID: 23462419. PMC3963403. 236. Chaichana KL, Martinez-Gutierrez JC, De la Garza-Ramos R, Weingart JD, Olivi A, Gallia GL, Lim M, Brem H, Quiñones-Hinojosa A: Factors associated with survival for glioblastoma patients who present with poor pre-operative functional status. J Clin Neurosci. 2013; 20(6):818-23. PMID: 23639620. PMC3994533. 237. Grossman R, Tyler B, Rudek MA, Kim E, Zadnik P, Khan U, Blakeley JO, Pathak AP, Brem H. Microdialysis Measurement of Intratumoral Temozolomide Concentration after Cediranib, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, in a U87 Glioma Model. Cancer Chemother Pharmacol. 2013; 72(1):93-100. Epub 2013 May 7. PMID: 23649683. 238. Sattler R, Tyler BM, Hoover B, Coddington LT, Recinos V, Hwanf L, Brem H, Rothstein JD. Increased expression of glutamate transporter GLT-1 in peri-tumor tissue prolongs survival and decreases tumor growth in a rat model of experimental malignant glioma. Laboratory investigation. J Neurosurg. 2013;119(4):878-86. Epub 2013 Aug 2. PMID: 23909244. PMC4086647. 239. Nabors LB, Ammirati M, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Holdhoff M, Junck L, Lawson R, Loeffler JS, Maor MH, Moots PL, Morrison T, Mrugala MM, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK Jr, Tran D, Tran N, Vrionis FD, Wen PY, McMillian N, Ho M. Central Nervous System Cancers. J Natl Compr Canc Netw.; 2013; 1;11(9):1114-51. PMID: 24029126: PMC4124889. 240. Chaichana KL, Gadkaree S, Rao K, Link T, Rigamonti D, Purtell M, Browner I, Weingart J, Olivi A, Gallia GL, Bettegowda C, Brem H, Lim M, Quinones-Hinojosa A. Patients undergoing surgery of intracranial metastases have different outcomes based on their primary pathology. Neurol Res. 2013 Dec;35(10):105969.Epub 2013 Aug 16. PubMed PMID: 24070329; PMC3994530. 241. Chaichana KL, Flores M, Acharya S, Sampognaro P, Bettegowda C, Rigamonti D, Weingart JD, Olivi A, Gallia GL, Brem H, Lim M, Quinones-Hinojosa A. Survival and recurrence for patients undergoing surgery of skull base intracranial metastases. J Neurol Surg B Skull Base. 2013 Aug;74(4):228-35. Epub 2013 Apr 3. PMID: 24436917; PMC3715603. Updated 10/26/2015

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242. Chaichana KL, Acharya S, Flores M, Wijesekera O, Rigamonti D, Weingart JD, Olivi A, Bettegowda C, Gallia GL, Brem H, Quinones-Hinojosa A. Identifying better surgical candidates among RPA class 2 patients who underwent surgery for intracranial metastes. World Neurosurg. 2013 Sep 25. pii: S18788750(13)01052-8 [Epub ahead of print] PMID: 24076052; PMC3995859. 243. Baia GS, Caballero OL, Ho JS, Zhao Q, Cohen T, Binder ZA, Salmasi V, Gallia GL, Quinones-Hinojosa A, Olivi A, Brem H, Burger P, Strausberg RL, Simpson AJ, Eberhart CG, Riggins GJ. NY-ESO-1 expression in meningioma suggests a rationale for new immunotherapeutic approaches. Cancer Immunol Res. 2013 Nov;1(5):296-302. Epub 2013 Aug 5. PMID: 24777967 244. Grossman R, Brastianos H, Blakeley JO, Mangraviti A, Lal B, Zadnik P, Hwang L, Wicks RT, Goodwin RC, Brem H, Tyler B. Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models. J Neurooncol. 2014 Jan;116(1):59-65. Epub 2013 Nov 2. PMID:24185441. PMC4037922. 245. Chaichana KL, Jusue-Torres I, Navarro-Ramirez R, Raza SM, Pascual-Gallego M, Ibrahim A, HernandezHermann M, Gomez L, Ye X, Weingart JD, Olivi A, Blakeley J, Gallia GL, Lim M, Brem H, QuinonesHinojosa A. Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma. Neuro Oncol. 2014 Jan;16(1):113-22. PMC3870832. 246. Chaichana KL, Rao K, Gadkaree S, Dangelmajer S, Bettegowsda C, Rigamonti D, Weingart J, Olivi A, Gallia GL, Brem H, Lim M, Quinones-Hinojosa A. Factors associated with survival and recurrence for patients undergoing surgery of cerebellar metastases. Neurol Res. 2014 Jan;36(1):13-25 245. Epub 2013 Oct 23. PubMed PMID: 24070068. 247. Bow H, Hwang L, Schildhaus N, Xing J, Murray L, Salditch Q, Ye X, Zhang Y, Weingart J, Brem H, Tyler B. Local delivery of angiogenesis-inhibitor minocycline potentiates radiotherapy and oral temozolomide chemotherapy in 9L glioma. Neurosurg. 2014 Mar;120(3):662-9. Epub 2013 Dec 20. PMID: 24359008. 248. Starmer HM, Ward BK, Best SR, Gourin CG, Akst LM, Hillel A, Brem H, Francis HW. Patient-Perceived Long-Term Communication and Swallow Function Following Cerebellopontine Angle Surgery. Laryngoscope; 2014;124(2):476-80. Epub 2013 Jun 26. PMID: 23775221. 249. Bydon M, Martin Ma T, Xu R, Weingart J, Olivi A, Gokaslan ZL, Tamargo RJ, Brem H, Bydon A. Surgical outcomes of craniocervial junction meningiomas: A series of 22 consecutive patients. Clin Neurol Neurosurg. 2014 Feb;117:71-9. Epub 2013 Dec 7. PMID: 24438809. 250. Yohay K, Tyler B, Weaver KD, Pardo AC, Gincel D, Blakeley J, Brem H, Rothstein JD. Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models. J Neurosurg. 2014;120(4):854-63. Epub 2014 Jan 31PMID: 24484234. 251. Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, Lee CC, Fecher LA, Gallia GL, Gibbs P, Le D, Giuntoli RL, Goggins M, Hogarty MD, Holdhoff M, Hong SM, Jiao Y, Juhl HH, Kim JJ, Siravegna G, Laheru DA, Lauricella C, Lim M, Lipson EJ, Marie SK, Netto GJ, Oliner KS, Olivi A, Olsson L, Riggins GJ, Sartore-Bianchi A, Schmidt K, Shih lM, Oba-Shinjo SM, Siena S, Theodorescu D, Tie J, Harkins TT, Veronese S, Wang TL, Weingart JD, Wolfgang CL, Wood LD, Xing D, Hruban RH, Wu J, Allen PJ, Schmidt CM, Choti MA, Velculescu VE, Kinzler KW, Vogelstein B, Papadopoulos N, Diaz LA Jr. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014 19;6(224):224ra24. PMC4017867. 252. Gabikian P, Tyler BM, Zhang I, Li KW, Brem H, Walter KA. Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres. J Neurosurg. 2014;120(5):1078-85. Epub 2014 Mar 7. PMID: 24605841. 253. Wicks RT, Huang Y, Zhang K, Zhao M, Tyler BM, Suk I, Hwang L, Ruzevick J, Jallo G, Brem H, Pradilla G, Kang JU. Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy. Stroke. 2014 Apr;45(4):1123-30. Epub 2014 Mar 13. PMC3971651. 254. Belcaid Z, Phallen JA, Zeng J, See AP, Mathios D, Gottschalk C, Nicholas S, Kellett M, Ruzevick J, Jackson C, Albesiano E, Durham NM, Ye X, Tran PT, Tyler B, Wong JW, Brem H, Pardoll DM, Drake CG, Lim M. Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model. PLoS One. 2014 Jul 11;9(7):e101764. PMC4094423.

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255. Wicks RT, Azadi J, Mangraviti A, Zhang I, Hwang L, Joshi A, Bow H, Hutt-Cabezas M, Martin KL, Rudek MA, Zhao M, Brem H, Tyler BM. Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma. Neuro Oncol. Neuro Oncol. 2015 Jan;17(1):70-80. PMC4483048 256. Woodworth GF, Dunn GP, Nance EA, Hanes J, Brem H. Emerging insights into barriers to effective brain tumor therapeutics. Front Oncol. 2014 Jul 21;4:126. PMC4104487. 257. Upadhyay UM,Tyler BM, Patta YR,Wicks RT, Spencer KC, Scott AW, Masi B, Hwang LS, Grossman R, Cima M, Brem H, Langer R. Intracranial Microcapsule Chemotherapy Delivery for the Localized Treatment of Rodent Metastatic Breast Adenocarcinoma in the Brain. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16071-6. PMC4234553 258. Nabors LB, Portnow J, Ammirati M, Brem H, Brown P, Butowski N, Chamberlain MC, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hattangadi-Gluth J, Hesser D, Holdhoff M, Junck L, Lawson R, Loeffler JS, Moots PL, Mrugala MM, Newton HB, Raizer JJ, Recht L, Shonka N, Shrieve DC, Sills AK Jr, Swinnen LJ, Tran D, Tran N, Vrionis FD, Wen PY, McMillian NR, Ho M. Central nervous system cancers, version 2.2014. J Natl Compr Canc Netw. 2014 Nov;12(11):1517-23. PMC4337873 259. Bydon M, Abt NB, Macki M, Brem H, Huang J, Bydon A, et al. Preoperative anemia increases postoperative morbidity in elective cranial neurosurgery. Surg Neurol Int 2014;5:156. PMC4235129 260. Mangraviti A, Tzeng SY, Kozielski KL, Wang Y, Jin Y, Gullotti D, Pedone M, Buaron N, Liu A, Wilson DR, Hansen SK, Rodriguez FJ, Gao GD, DiMeco F, Brem H, Olivi A, Tyler BM, Green JJ. Polymeric Nanoparticles for Non-Viral Gene Therapy Extend Brain Tumor Survival In Vivo. ACS Nano. 2015 Feb 24;9(2):1236-49. PMC4342728 261. Mangraviti A, Tyler BM, Brem H. Interstitial Chemotherapy for Malignant Glioma: Future Prospects In The Era Of Multimodal Therapy. Surg Neurol Int 2015;6:S78-84. PMC4338488 262. Zhang F, Mastorakos P, Mishra MK, Mangraviti A, Hwang L, Zhou J, Hanes J, Brem H, Olivi A, Tyler B, Kannan RM. Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers. Biomaterials. 2015 Jun;52:507-16. PMID:25818456 [PubMed - in process] 263. Chaichana KL, Pinheiro L, Brem H. Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas. Ther Deliv. 2015 Apr;6(3):353-69. PMID: 25853310 [PubMed - in process] 264. Sesen J, Dahan P, Scotland SJ, Saland E, Dang VT, Lemarié A, Tyler BM, Brem H, Toulas C, CohenJonathan Moyal E, Sarry JE, Skuli N. Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response. PLoS One. 2015 Apr 13;10(4):e0123721. PMC4395104 265. Chaichana KL, Kone L, Bettegowda C, Weingart JD, Olivi A, Lim M, Quinones-Hinojosa A, Gallia GL, Brem H. Risk of surgical site infection in 401 consecutive patients with glioblastoma with and without carmustine wafer implantation. Neurol Res. 2015 Aug;37(8):717-26. PMID:25916669. 266. Berli JU, Thomaier L, Zhong S, Huang J, Quinones A, Lim M, Weingart J, Brem H, Gordon CR. Immediate Single-Stage Cranioplasty Following Calvarial Resection for Benign and Malignant Skull Neoplasms Using Customized Craniofacial Implants. J Craniofac Surg. 2015 Jul;26(5):1456-62. 267. Kim JE, Patel MA, Mangraviti A, Velarde E, Theodros D, Mathios D, Jackson CM, Tyler B, Ye X, Brem H, Pardoll D, Lim M. 143 The Combination of anti-TIM-3 and anti-PD-1 Checkpoint Inhibitors With Focused Radiation Resulted in a Synergistic Antitumor Immune Response in a Preclinical Glioma Model. Neurosurgery. 2015 Aug;62 Suppl 1, CLINICAL NEUROSURGERY:212. 268. Wang Y, Springer S, Zhang M, McMahon KW, Kinde I, Dobbyn L, Ptak J, Brem H, Chaichana K, Gallia GL, Gokaslan ZL, Groves ML, Jallo GI, Lim M, Olivi A, Quinones-Hinojosa A, Rigamonti D, Riggins GJ, Sciubba DM, Weingart JD, Wolinsky JP, Ye X, Oba-Shinjo SM, Marie SK, Holdhoff M, Agrawal N, Diaz LA Jr, Papadopoulos N, Kinzler KW, Vogelstein B, Bettegowda C. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9704-9. PMC4534284 269. Grossman R, Burger P, Soudry E, Tyler B, Chaichana KL, Weingart J, Olivi A, Gallia GL, Sidransky D, Quiñones-Hinojosa A, Ye X, Brem H. MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel. J Clin Neurosci. 2015 Aug 3 [Epub ahead of print] 270. Nabors LB, Portnow J, Ammirati M, Baehring J, Brem H, Brown P, Butowski N, Chamberlain MC, Fenstermaker RA, Friedman A, Gilbert MR, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Lawson R, Loeffler JS, Lovely MP, Moots PL, Mrugala MM, Newton HB, Parney I, Raizer JJ, Recht L, Shonka N, Shrieve DC, Sills AK Jr, Swinnen LJ, Tran D, Tran N, Vrionis FD, Weiss S, Wen PY, McMillian N, Engh

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AM. Central Nervous System Cancers, Version 1.2015. J Natl Compr Canc Netw. 2015 Oct;13(10):1191202. 271. Jackson CM, Kochel CM, Nirschl CJ, Durham NM, Ruzevick J, Alme A, Francica BJ, Elias J, Daniels A, Dubensky TW Jr, Lauer P, Brockstedt D, Baxi EG, Calabresi PA, Taube JM, Pardo CA, Brem H, Pardoll DM, Lim M, Drake CG. Systemic Tolerance Mediated by Melanoma Brain Tumors is Reversible by Radiotherapy and Vaccination. Clin Cancer Res. 2015 Oct 21. pii: clincanres.1516.2015. [Epub ahead of print] 272. Yoshida J, Wicks RT, Zambrano AI, Tyler BM, Javaherian K, Grossman R, Daoud YJ, Gelbach P, Brem H and Stark WJ. Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis. J Ophthalmol. 2015;2015:137136. doi: 10.1155/2015/137136. Epub 2015 Sep 28.

Editorials, Reviews: "Hurting Care, and Lives." Henry Brem and Benjamin S. Carson Sr. The Washington Post, Washington, D.C.; Editorial Commentary, December 28, 2004, A-19.

Book Chapters, Monographs: 1.

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13. 14.

Brem H, Arensman R, and Folkman J. "Inhibition of tumor angiogenesis by a diffusible factor from cartilage." In Extracellular Matrix Influences on Gene Expression, H. Slavkin, Editor, (Academic Press, New York), l975, pp. 767-772. Brem H. "Inhibition of neovascularization by an extract from cartilage." In New Research in Diabetic Retinopathy, A. Patz, Editor, (Juvenile Diabetes Foundation, N.Y.), l978, pp. 67-88. Brem H. "Control of neovascularization." In Diabetic Renal- Retinal Syndrome, E.A. Friedman and F.A. L'Esperance, Editors, (Grune & Straton, N.Y.), l980, pp. 291-294. Brem H. "The Angiogenesis factor in ocular neovascularization." In Diabetic Renal-Retinal Syndrome, Vol. II, Prevention and Management. E.A. Friedman and F.A. L'Esperance, Editors, (Grune and Straton, N.Y.), l982, pp. 151-154. Brem H "Supratentorial astrocytoma." In Current Therapy in Neurological Surgery, D.M. Long, Editor, (B.C. Decker, Publishers Inc., Toronto-Philadelph) 1986, pp. 27-29. Brem H. "Glioma." In Current Therapy in Internal Medicine, T.M. Bayless, M.C. Brain, R.M. Cherniack, Editors, (B.C. Decker, Inc., Philadelphia), 1987, pp 1302-1304. Brem H. "Glioma." In Current Therapy in Neurologic Disease-2, R.T. Johnson, Editor, (B.C. Decker, Inc., Toronto), l987, pp. 202-204. Brem H, Tamargo R, Guerin C, Brem S, and Brem H. "Brain tumor angiogenesis." In Advances in Neurooncology, P.L. Kornblith, Editor, (Futura Publishing Company, Inc., Mount Kisco, NY), 1988, pp. 89-101. Hanley DF, Brem H, Moses H III, Rogers MC. "Elevated intracranial pressure." In Principles and Practice of Medicine, Harvey et al, Editors, (Appleton & Lange, Norwalk, CT.), XXII Edition, l988, pp 253-258. Brem H, Grossman S, and Hanley DF. "Intracranial masses." In Principles and Practice of Medicine, Harvey el al, Editors, (Appleton & Lange, Norwalk, CT.), XXII Edition, l988, pp. 1052-1057. Brem H. "Malignant glioma." In Current Therapy in Neurological Surgery-2. D.M. Long, Editor, (B.C. Decker, Inc., Philadelphia-Toronto), 1989, pp. 43-45. Chasin M, Domb A, Ron E, Mathiowitz E, Leong K, Laurencin C, Brem H, Grossman S, and Langer R. "Polyanhydrides as drug delivery systems." In Biodegradable Polymers as Drug Delivery Systems, Mark Chasin and Robert Langer, Editors, (Marcel Dekker, Inc., New York), 1990, pp. 43-70. Brem H. "Controlled delivery to the brain." In Targeting of Drugs: Optimization Strategies, G. Gregoriadis, Editor, (Plenum Press, N.Y.), 1990, pp. 155-163. Olivi A, Domb A, Lenartz D, Tamargo R, Brem H. "Interstitial chemotherapy with drug impregnated polymer implants to treat brain tumors: Pre-clinical and clinical studies." In Neuro-Oncology, P. Paoletti, K.

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Takakura, M.D. Walker, G. Butti, S. Pezzotta, Editors, (Kluwer Academic Publishers, Dordrecht, The Netherlands), 1991, pp. 221-223. Kennedy D, Brem H, and Zinreich J. "Transsphenoidal Pituitary Surgery." In Skull Base Tumors, D.M. Long, editor, (Blackwell Scientific, Philadelphia), 1992, pp. 149-173. Olivi A, Brem RF, McPherson R, Brem H. "Brain tumors in Pregnancy." In Neurological Complications of Pregnancy. B. Stern, Editor, (Futura Publishing Co., Mount Kisco, NY), 1992, pp 85-105. Guerin C, Tamargo RJ, Olivi A, Brem H. "Brain tumor angiogenesis: Drug delivery and new inhibitors." In Angiogenesis in Health and Diseases, M. E. Maragoudakis, Editor, (Plenum Press, New York), 1992, pp. 265-274. Weingart J and Brem H. "Brain tumors: Diagnosis and surgical management." In Current Therapy in Oncology, J. E. Niederhuber, Editor, Mosby Year-book, Inc. (B.C. Decker, Inc., Philadelphia-Toronto), 1993, pp 538-541. Brem H, Tamargo RJ, and Olivi A. "Delivery of drugs to the brain by use of a sustained-release polyanhydride polymer system." In New Technologies and Concepts for Reducing Drug Toxicities, Harry Salem and Steven I. Baskin, Editors, (CRC Press, Boca Raton, Florida), 1993, pp 33-39. Walter KA, Brem H. "Polymers as controlled drug delivery systems for the brain." In Cerebral Revascularisation, Eugene P. Bernstein, Allan D. Callow, Andrew N. Nicolaides, Edward G. Shifrin, editors, (Med-Orion Publishing Company, Sunland, California), 1993, pp. 237-246. Olivi A, Brem, H. "Interstitial chemotherapy with sustained-release polymer systems for the treatment of malignant gliomas." In Recent Results in Cancer Research, Vol. 135, Uwe Schlegel, editor, (Springer Verlag, Amsterdam), 1994, pp 149-154. Brem H, Walter KA, Tamargo RJ, Olivi A, Langer RS. "Drug Delivery to the Brain." In Polymer SiteSpecific Pharmacotherapy, Abraham J Domb, Editor, (John Wiley & Sons, Ltd., England), 1994, pp 117-139. Tamargo RJ, Langer R, Brem H. "Interstitial drug delivery to the central nervous system using controlled release polymers: chemotherapy for brain tumor." In Providing Pharmacological Access to the Brain, (a volume of Methods in Neurosciences) Thomas R. Flanagan, Dwaine F. Emerich and Shelley R. Winn, Editors, (Academic Press, Inc., Orlando, FL), 1994, Vol.21, pp. 135-149. Sipos EP, Brem H. "Angiogenesis in nervous system tumors." In Cancer of the Nervous System (Basic Science Section), Peter McL. Black and Jay S. Loeffler, Editors, (Blackwell Scientific Publications, Inc. Cambridge, Massachusetts), 1996, pp 813-826. Weingart JD, Laterra J, Brem H. "Growth factors and angiogenesis." In Bailliere's Clinical Neurology/Cerebral Gliomas, WKA Yung, editor, (Bailliere Tindall, London), 1996, pp 307-318. Storm PB, Brem H. "The treatment of brain tumors with drug-impregnated biodegradable polymers." In, Advances in Neuro-Oncology, Vol. II. Paul Kornblith and Michael Walker, editors, (Futura Publishing Co., Inc., Armonk, N.Y.), 1997, pp. 435-446. Sills AK, Sipos EP, Laterra J, Brem H. "Angiogenesis in central nervous system tumors." In Advances in Neuro-Oncology, Vol. II. Paul Kornblith and Michael Walker, editors, (Futura Publishing Co., Inc., Armonk, N.Y.), 1997, pp. 81-96. Anderson RC, Ewend ME, Brem H. "Interstitial chemotherapy: Potential for use in CNS metastases." In Advanced Techniques in Central Nervous System Metastases, Editor, Robert J. Maciunas, 1998, pp. 177-194. Watts M, Brem H. "Neurosurgery." In Fundamentals of Surgery, Editor, John E. Niederhuber, (Appleton & Lange, Stamford, CT.), 1998, Chapter 43, pp 721-739. Thompson RC, Brem H. "Treatment of gliomas using polymer-drug delivery." In The Gliomas, Editors, Charles B. Wilson and Mitchel S. Berger, (W.B.Saunders Co., Cambridge, MA.), 1999, Chapter 46, pp 555563. Burke M, Langer R, Brem H. “Drug delivery to the central nervous system.” In The Encyclopedia of Controlled Drug Delivery, Editors Edith Mathiowitz, (John Wiley & Sons, Inc. New York), 1999, pp 184212. Weingart J, Rhines L, Brem H. “Intratumoral chemotherapy.” In Essential Neuro-Oncology, Editors, Mark Bernstein and Mitchel S. Berger, (Thieme Publishers, New York), 2000, pp 240-248. Long DM, Brem H, Benn Debba M. “Neurosurgery.” In Evidence-Based Surgery, Editors, Toby Gordon and John L. Cameron, (B.C. Decker Inc, Ontario, Canada), 2000, pp.629-642. Davis JD, Vanier V, Brem H. "Slow-release polymers for chemotherapy.” In Neural Prostheses, Editor, Robert J. Maciunas, (AANS Park Ridge, IL), 2000, Chapter 9, pp 157-183. Rhines LD, Ewend MG, Brem H. “Drug delivery and angiogenesis inhibition in the treatment of brain

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tumors. In Tumor Angiogenesis and Microcirculation, Editors, Drs. Emile Voest and Patricia A.D’Amore, (Marcel Dekker, Inc, New York, NY), 2001, Chapter 22, pp.361-374. DiMeco F, Petrangolini G, Rizzo R, Olivi A, Brem H. "Polimeri biodegradabili e rilascio locale di chemioterapici." In La Terapia Dei Tumori Cerebrali Maligni dell'Adulto e del Bambino," Editor, A. Sghirlanzoni, A. Boiardi, (Springer-Verlag Italia Srl, Milano, Italia), 2002, pp 139-145. Laterra J, Brem H. "Primary brain tumors in adults." In Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles, 3rd Edition, Editors, Arthur Asbury, Ian McDonald, Guy McKhann, Peter Goadsby, Justin McArthur, (Cambridge University Press,) Cambridge, UK.,(Chap 87) 2002, pp. 14311447. DiMeco F, Brem H, Weingart J, Olivi A. "Gliadel™ A new method for the treatment of malignant brain tumors." IN Drug Delivery Systems in Cancer Therapy, editor, Dennis Brown, (Humana Press Inc., Totowa, NJ), 2003, pp 215-227. Brem H, Sawaya R. "Brain tumors: General considerations." In Youmans Neurological Surgery 5th Edition, (Vol.I editors, Brem, Sawaya.) H. Richard Winn, editor, (Saunders, Philadelphia, PA.), 2004, pp 659-660. Weingart J, Brem H. "Basic principles of cranial surgery for brain tumors." In Youmans Neurological Surgery 5th Edition, (Vol. editors, Brem, Sawaya). H. Richard Winn, editor, (Saunders, Philadelphia, PA.), 2004, pp 899-907. Lesniak M, Frazier J, Brem H. "Targeting drugs to tumors of the Central Nervous System." In Contemporary Cancer Research: Brain Tumors, editor, F. Ali-Osman (Humana Press, Totowa, NJ), 2004, Chapter 18, pp 343-358. Wang P and Brem H. "Neurosurgical applications for polymeric drug delivery systems." In Progress in Neurological Surgery, Series Editor: L.D.Lunsford. Vol 18, Principles of Molecular Neurosurgery Volume Editors: A. Freese, F.A. Simeone, P. Leone, C. Janson. (Karger Publishers, Switzerland), 2005, pp. 458-498. Khalessi A, Wang P, Brem H., Langer R. "Treatment of malignant brain tumors with controlled-release local-delivery polymers." In Polymeric Drug Delivery Systems, Editor, Glen S. Kwon, (Marcel Dekker, Inc., New York), Drugs and the Pharmaceutical Sciences, 2005, Vol 148, Chapter 8, pp 323-380. Haque RM, Amundson E, Dorsi M, Brem H. "Interstitial Chemotherapy and Polymer Drug Delivery" In: Handbook of Brain Tumor and Chemotherapy, Editor, Herbert B. Newton, (Elsevier Inc, The Netherlands), 2006, Chapter 19, pp 274-294. Weingart JD, McGirk MJ, Brem H. "High Grade Astrocytoma." In Neuro-Oncology of CNS Tumors, Editors JC Tonn, M, Westphal, J Rutka, S Grossman, (Springer-Verlag, Heidelberg, Germany), 2006, Chapter 6, pp 127-138. Bohan EM, Gallia G, Brem H. “Brain Tumors.” In: Neuroscience Nursing-Spectrum of Care, 3rd Edition, Editor, E. Barker, (Mosby, Inc., St. Louis, Missouri), 2008, pp. 215-248. Brem H, Weingart JD, Kunwar S. "Intratumoral Therapy." In Neuro-Oncology: The Essentials, 2nd Edition, Editors: Mark Bernstein and Mitchel Berger (Thieme Medical Publishers, Inc., New York, NY),. 2008 Brem H, Chiocca EA, Sawaya R. “Brain Tumors: General Considerations”. InYoumans Textbook of Neurological Surgery-6th Edition,(Vol. 2 editors, Brem, Sawaya and Chiocca) H. Richard Winn, editor, (Saunders, Philadelphia, PA.). 2011, pp 1075-1076. Brem H, Weingart. “Basic Principles of Cranial Surgery for Brain Tumors”. InYoumans Textbook of Neurological Surgery-6th Edition,(Vol. 2 editors, Brem, Sawaya and Chiocca) H. Richard Winn, editor, (Saunders, Philadelphia, PA.). 2011, pp 1261-1266. Quinones-Hinojosa A, Kosztowski T, Brem H. “Malignant Gliomas: Anaplastic Astrocytoma, Glioblastoma Multiforme, Gliosarcoma”. InYoumans Textbook of Neurological Surgery-6th Edition,(Vol. 2 editors, Brem, Sawaya and Chiocca) H. Richard Winn, editor, (Saunders, Philadelphia, PA.). 2011, pp 1327-1340. Chaichana KL, Weingart JD, Brem H. " Intratumoral and Interstitial Chemotherapy." In NeuroOncology: The Essentials, 3rd Edition, Editors: Mark Bernstein and Mitchel Berger (Thieme Medical Publishers, Inc., New York, NY),. In process. Uribe R, Brem H, Jallo G “Ectopic Occurrence of Craniopharyngiomas.” In Craniopharyngiomas: A Comprehensive Guide to Diagnosis, Treatment and Outcome, Editors Tyler Kenning and James J. Evans (Elsevier Academic Press), 2015, pp 501-510. Paldor I, Chaichana KL, Brem H, Tyler B. “Targeted Local Therapy for the Treatment of Intracranial High Grade Gliomas.” In Progress in Neurological Surgery. Editors, Mikhail F. Chernov (Tokyo, Japan), Yoshihiro Muragaki (Tokyo, Japan), Santosh Kesari (La Jolla, CA), and Ian E. McCutcheon (Houston, TX). (Karger Publishers). In press.

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Books: Guest Editor, Special Edition: Implant Approach to Chemotherapy, (JNO) 1995. Section Editor, Youmans Textbook of Neurological Surgery-5th Edition, 2004. Section Editor, Youmans Textbook of Neurological Surgery-6th Edition, 2011 Section Editor, Youmans Textbook of Neurological Surgery-7th Edition, in progress

Other media (films, videos, CD-ROMSs, slide sets): http://www.hopkinsmedicine.org/news/audio/podcasts/BremPod.html http://www.hopkinsmedicine.org/neurology_neurosurgery/video_gallery/brem-carlos-luceno-brain-tumor.html http://www.hopkinsmedicine.org/neurology_neurosurgery/news/videos/brem-neurosurgery-dept-video.html http://www.npr.org/blogs/health/2011/01/10/132810638/how-neurosurgeons-size-up-brain-injuries-like-giffords http://www.pbs.org/newshour/bb/health/jan-june11/brain_01-17.html# http://webcast.jhu.edu/mediasite/Viewer/?peid=b31f3529438344cbab4cf0af5800c22a Part 1 http://www.youtube.com/watch?v=Q3QIdGXIknY&feature=related Part 2 http://www.youtube.com/watch?v=huihBDTcd2s http://www.hopkinsmedicine.org/neurology_neurosurgery/news/videos/brem-new-brain-tumor-therapies.html http://webcast.jhu.edu/mediasite/Viewer/?peid=f5f4fd8ca9fc422babcba667374b000b1d http://webcast.jhu.edu/mediasite/Viewer/?peid=aa0933bd17de42c4a967b0a5a9aa4299 http://www.youtube.com/watch?v=CvLHY9ptllg&feature=plcp http://www.youtube.com/watch?v=RuA5EZkeW7I http://www.youtube.com/watch?v=z5O_PNHQj8U

Inventions, Patents, Copyrights (pending, awarded)

Patents: Antibiotic Composition for Inhibition of Angiogenesis. Henry Brem, Rafael J. Tamargo, Robert A. Bok U.S. Patent Number: 6,482,810 B1 Date: Nov 19, 2002 Controlled Local Delivery of Chemotherapeutic Agents for Treating Solid Tumors. Updated 10/26/2015

Henry Brem, M.D.

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Henry Brem, Robert S. Langer, Abraham J. Domb Japanese Patent Application No. 8-506742 (August 2, 1995) U.S. Patent Number: 5,626,862 Date: May 6, 1997 U.S. Patent Number: 5,651,986 Date: July 29, 1997 U.S. Patent Number: 5,846,565 Date: Dec 8, 1998 European Patent No: 0,774,964A: AT,BE,CHDE,DK,ES,FR,GB,GR,IE,IT, LI,LU,MC,NL,PT,SE Cytokine Enhanced Immunotherapy for Brain Tumors. Henry Brem, Drew M. Pardoll, Reid C. Thompson, Elizabeth M. Jaffee, Kam W. Leong, Matthew G. Ewend JH 100 (DM3026) USSN 08/731,597 Publication # EP0930892 A1, July 28, 1999 Vitamin D3 Analog Loaded Polymer Formulations for Cancer and Neurogenerative Disorders. Martin Burke, Maria-Christina White, Jae Kyoo Lee, Mark C. Watts, Betty M. Tyler, Gary H. Posner, Henry Brem. USSN Application No. 12/165,036 Filing Date: 6/30/2008 Publication No.: US-2008-0260834-A1 Pub date: 10/23/2008 Intracellular Delivery of Anionic Anti-cancer Drugs with Cationic Polymers. D. Berry, G. Anderson, R Langer, B Tyler, H. Brem. MIT Case No. 11598 Combination of Local Temozolomide with Local BCNU V. Renard Recinos, B. Tyler, S. Brem Sunshine, H. Brem. USSN Application No. 13/163223 Filing Date 6/17/2011 Patent # 8895597 Published November 25, 2014 Intraoperatively Placed Markers for Post-surgical Imaging M. Lim, H. Brem, B.Tyler, J. Liauw, S. Lo

Extramural Sponsorships (current, pending, previous): GRANTS – Current: 4/1/15 – 3/31/16

Allegheny Health Network-Johns Hopkins Cancer Research Fund “Multimodal peptide-containing biodegradable nanoparticles for Glioblastoma” Total DC: $200,000 Role: Co-P.I. Effort: 5% P.I. Aleksander S. Popel

5/7/12-3/31/17

NIH 5R01CA164789-03 “Brain Tumor-Penetrating Nanoparticle Delivery with MR-Guided Focused Ultrasound” JHU Total DC: $1,250,000 Role: Co-P.I. Effort: 5% P.I. Richard Price (UVA)

2011 – 2016

“Subependymoma and Ependymoma Program Project Grant Total DC: $2,500,000 Role: Co-P.I. Effort: 5% P.I. Michael Lim

2011 - 2016

“Translational Research Partners Program” The Wallace H. Coulter Foundation Total DC: $5,000,000

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Henry Brem, M.D.

Role: Co-P.I.

Effort: 0%

P.I. Elliot McVeigh

9/1/10 - 8/10/15

NIH 5R25CA153952-04 “Postdoctoral Training Program in Nanotechnology for Cancer Medicine” Total Cost: $1,353,807 Role: Participating Faculty Effort 0% P.I. Denis Wirtz

5/1/04-6/30/15

NIH 5T32EB003383-10 “Training Program in Neuroengineering” Total Cost $3,528,005 Role: Participating Faculty Effort 0%

GRANTS-Pending RO1 9/1/15 – 8/31/20 Nucleic Acid Delivery to Brain Tumors Role: Co-Investigator

23

P.I. Nitish Thakor

P.I. Justin Hanes

9/1/15 – 8/31/18

ICRF Israel Cancer Research Fund P.I Avi Domb Elevated Expression, Mutations and Therapeutic Targeting of Dopamine D Receptor in Cancer Role: Co-PI

9/1/15-8/30/20

NIH-CCNE RFA-CA-14-013 P.I. Justin Hanes Targeted Delivery of Brain Penetrating DNA Nanoparticles to Brain Tumors Role: Co-Investigator

GRANTS–Previous 9/19/90-4/30/95 (1st cycle)

“Controlled Release Polymers for Brain Tumors” NCI/NCDDG 2 U19 CA52857 TDC: $4,126,592 Role: P.I. Effort 19%

9/19/95-4/30/00 (2nd cycle)

“Controlled Release Polymers for Brain Tumors” NCI/NCDDG 2 U19 CA52857 TDC: $2,189,021 Role: P.I. Effort 19%

9/19/00-4/30/06 (3rd cycle)

"Controlled Release Polymers for Brain Tumors," NIH, NCI, National Cooperative Drug Discovery Group. UO1 CA52857 TDC: $4,488,080 Role: P.I. Effort 19%

7/1/91-5/31/95

"The Physiologic Imaging Human Brain Tumors" NIH, NCI, RO1-CA54112 TDC: $630,028 Role: Co-investigator Effort 1% P.I.:R. Nick Bryan

6/10/92-12/31/03

"Research Training in Oncology Imaging" NIH, NCI, T32 CA09630 NCI National Research Service Award Total DC: $559,478 Role: Training Faculty Effort 5% P.I.: Z. Bhujwalla

7/1/93-6/30/96

"Vascular Biology of Brain Tumors" Feasibility Grant for Brain Tumor Research Center NIH, NCI, P20-CA60172

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Henry Brem, M.D.

TDC: $891,428 Role: P.I.

Effort 25%

3/21/94-12/31/97 (1st Cycle)

"New Approaches to Brain Tumor Therapy CNS Consortium" NIH, NCI, UO1 CA62474 TDC: $307,540 Role: P.I. Effort 10%

3/21/98-12/31/03 (2nd Cycle)

"New Approaches to Brain Tumor Therapy CNS Consortium," NIH, NCI, UO1 CA62474 TDC: $479,807 Role: P.I. Effort 9%

5/18/04-12/31/08 (3rd cycle)

"New Approaches to Brain Tumor Therapy CNS Consortium" NIH, NCI, UO1 CA62474 Total Project DC: $483,133 Role: P.I. Effort 5%

3/21/94-12/31/97 (1st Cycle)

"New Approaches to Brain Tumor Therapy CNS Consortium" NIH, NCI, UO1 CA62475 Total DC: $694,614 Role: Co-P.I. Effort 10% P.I.: Stuart Grossman

3/21/98-12/31/02 (2nd cycle)

"New Approaches to Brain Tumor Therapy CNS Consortium," NIH, NCI, UO1 CA62475 TDC: $1,780,451 Role: Co- P.I. Effort 10% P.I.: Stuart Grossman

5/18/04-12/31/08 (3rd cycle)

"New Approaches to Brain Tumor Therapy CNS Consortium," NIH, NCI, UO1 CA62475 TDC: $2,573,487 Role: Co- P.I. Effort 5% P.I.: Stuart Grossman

9/1/94-8/31/99

"Molecular Biomarkers in the Classification of Gliomas" NIH, NCI UO1 CA64928 TDC: $804,932 Role: Co-investigator Effort 5% P.I.: Roy C. Levitt

9/1/99-6/30/04 (1st cycle)

“Microchip Drug Delivery System.” (MIT P.I.: Robert Langer) NIH, R24 AI-47739 JHU TDC: $415,096 Role: Co-investigator Effort 5% P.I.: Henry Brem (JHU)

9/1/00-8/31/03

"Non Viral Polymeric Vectors for Treating Brain Tumors Israel Binational Science Foundation (BSF) JHU Total DC: $24,000 Role: Co-P.I.: Effort: 5% P.I.: Abraham Domb (Israel)

5/1/05-4/30/07 (lst cycle)

"Enhancement of Brain Tumor Immunotherapy by Fas-L RNAi" NIH 1 R21 CA112148 TDC: $200,000 Role: Co-investigator Effort 2% P.I.: Alessandro Olivi

2008 - 2011

"Enhancement of Brain Tumor Immunotherapy by Fas-L RNAi" NIH 1 R21 CA112148

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24

Henry Brem, M.D.

TDC: $500,000 Role: Co-investigator

Effort 2%

25

P.I.: Alessandro Olivi

7/1/08-6/30/12

“Efficacy of Temozolomide for the Treatment of Malignant Glioma” American Cancer Society TDC.: $589,313 Role: Co-Investigator Effort 1% P.I.: Betty Tyler

8/1/07-7/31/12

NIH 9 RO1 EB006365-06 (Formerly RO1A1047739-06) (MIT, Robert Langer). "Microchip Drug Delivery System” (JHU) TDC: $414,636 Role: (Subcontract, Brem, P.I.) Effort: 5%

1987 - 2013

"Research Training in Neuro-Oncology" NIH/NCI National Research Service Award, T32 CA09574 Total Project DC: $1,318,370 Role: Co-P.I. Effort 1% P.I.: Stuart Grossman

5/1/97-4/30/14

"Regional Oncology Research Center Grant" NCI 5P30CA06973 -50S1 Total DC: $3,848,362 Role: Program Leader Effort 3% P.I. William Nelson

9/1/10-8/31/14

"Modified Pectin and High Intensity Focused Ultrasound for Non Invasive Brain Cancer Gene Therapy” Israel Binational Science Foundation (BSF) JHU Total DC: $22,425 Role: Co-P.I.: Effort: 3% P.I.: Joseph Kost (Israel)

CONTRACTS Previous: 1986 - 1991

Nova Pharmaceutical Corp "Development of Bioerodible Polyanhydride Polymers for Sustained Release of Chemotherapeutic Agents in the Brain" Nova Pharmaceutical Corporation Grant to Develop Total Period: 4/1/87 – 9/30/88 DC: $208,015 Effort: 15% Role: P.I. "Clinical Trial: Protocol NPC #8802: A Double Blind, Placebo-Controlled Study of BCNU Delivered from Gliadel, a Biodegradable Surgically Implanted Polymer for the Treatment of Recurrent, Malignant Glioma" Nova Pharmaceutical Corp Total Period: 3/1/89 – 9/1/90 DC: $20,470 Effort 1% Role: P.I. "Steroids in Gliadel to Treat Brain Edema" Safety & Efficacy Studies with VXZ Carcinoma in the Rabbit, Quantitative HPLC Distribution Studies, and Dosing Studies" Nova Pharmaceutical Corp Total Period: 7/1/89 – 6/30/90 DC: $120,489 Effort 10% Role: P.I. "Clinical Trial: NPC Protocol #9003 Interstitial Chemotherapy for Malignant Glioma: A Pilot Study to examine the safety of Gliadel Placed at the Time of First Surgery" Nova Pharmaceutical Corp Total Period: 7/1/90 – 7/31/91 DC: $25,000 Effort 1% Role: P.I.

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26

"Steroids in Gliadel to Treat Brain Edema" Efficacy and Drug Distribution of Dexamethasone and Triamcinolone from Gliadel in the Rat 9L Gliosarcoma Model" Nova Pharmaceutical Corp Total Period: 9/1/89 – 10/31/90 DC: $84,395 Effort 5% Role: P.I. "Preclinical Protocol to Evaluate Corticosteroids Released from Gliadel" Nova Pharmaceutical Corp. Total Period: 11/1/89 – 12/31/90 DC: $84,187 Effort 5% Role: P.I. "Steroids in Gliadel to Treat Brain Edema" Nova Pharmaceutical Corp. Total Period: 9/1/90 – 8/31/91 DC: $89,884 Effort 5% Role: P.I. "Steroids in Gliadel to Treat Brain Edema" Nova Pharmaceutical Corp Total Period: 11/1/90 – 4/30/91 DC: $70,349 Effort 5% Role: P.I. 7/1/89-6/30/91

"Biocompatibility of New Controlled Release Polymers in Rabbit & Rat in-vivo model Fidia Research Laboratories, Terme, Italy. DC: $72,646 Effort 2% Role: P.I.

2004-2005

CytoDome, Inc Project 1; "Ultrasound Delivery System with Systemic BCNU in the 9L Rat Flank Model" Total Period: 3/1/04 - 4/15/04 Total DC: $4,991 Effort 3% Role: P.I. Amendment 1; "Low Dose BCNU Polymer in 9L Rat Flank" 4/15/04 - 5/14/04 Total DC: $2,980 Effort 1% Role: P.I. Amendment 2, "Testing the Efficacy of the CytoDome device in the 9L Rat Flank Tumor Model with and without BCNU" Total Period: 2/15/05 - 4/15/05 Total DC: $3,499 Effort 1% Role: P.I. Amendment 3, "Testing the Efficacy of the CytoDome device in the 9L Rat Flank Tumor Model with and without BCNU" Total Period: 4/15/05 – 7/22/05 Total DC: $8,778 Effort 1% Role: P.I. Amendment 4, "Testing the Efficacy of the CytoDome device in the 9L Rat Flank Tumor Model with and without BCNU" Total Period: 08/01/05 – 12#105 Total DC: $23,163 Effort 1% Role: P.I.

5/1/05-8/31/04

MacroMed, Inc. "OncoGel Delivery System-Toxicity and Efficacy Studies" Total DC: $11,410 Effort 3% Role: P.I.

05/01/06-08/30/06 MacroMed, Inc. "OncoGel Controlled Release ReGel/Paclitaxel Delivery System-Toxicity and Efficacy Study" DC: $10,128 Effort 1% Role: P.I. 5/01/06-8/31/06

"The Effect of Neuregen for the Treatment of Malignant Glioma in an Experimental Rodent Model with and without Locally Delivered BNCU" Southern Illinois U (Gregory Brewer) Total DC: $1,297 Role: Consultant Effort 0% P.I.: Betty Tyler

5/1/02-4/30/07

"Anti-Excitotoxic Therapies to Target Glioma Growth" Accelerated Brain Tumor Cure (ABC2)

Updated 10/26/2015

Henry Brem, M.D.

TDC: $100,000 Role: Co- P.I. 1/1/06-4/30/07

Effort 2%

27

P.I.: Jeffrey Rothstein

"Talabostat and PT-630-an Efficacy Study with Intracranial Murine Melanoma" Point Therapeutics TDC $3,060 Effort 1% (no sal) Role: P.I.: Brem

12/01/07-03/31/08 “Combination Therapy with OncoGel and Other Chemotherapeutic Agents to Treat Experimental Malignant Glioma” Protherics, PLC T DC: $18,146 Effort 1% (no sal) Role: P.I. 4/1/07-11/30/08

"Safety and Efficacy Studies Using Zymes Compound in an Experimental Intracranial Rodent Glioma." Zymes, LLC. TDC $17,246 Role: Consultant (Effort 0/0) P.I.: B. Tyler

OTHER Previous: 1983 - 1985

"Detection of Human Central Nervous System Tumors" American Cancer Society Grant

PDT-228

1984 - 1985

"Inhibition of Brain Tumor Angiogenesis" American Cancer Society Institutional Grant

1985 - 1990

"Inhibition of Brain Tumor Angiogenesis" Total Period: 12/1/87 – 11/30/90 NCI, Clinical Investigator Development Award, 5 KO8-NS01058 DC: $289,440 Effort: 75% Role: P.I.

1987 - 1989

Clinician-Scientist Award, Andrew W. Mellon Foundation Grant for Faculty Development, Johns Hopkins University School of Medicine

1988 - 1989

"New Treatment with Sustained Release to the Brain" Alzheimer's Association

1993 - 1994

"Anti-angiogenesis Research." Preuss Foundation TDC: $50,000 Effort: 5%

Total Period: 1/1/03 – 12/31/03 Role: P.I.

2003-2004

"Haptoglobin and Tumor Angiogenesis" Technion Foundation Award; Joint JHU-Technion Program for Biomedical Sciences and Biomedical Engineering Total Period: 1/1/03 - 12/31/04 JHU DC: $66,666 Role: Co-P.I. Effort: 5% P.I. Brem (JHU)/Andy Levy (Israel)

3/1/07-10/31/07

"In Vivo Evaluation of Sugar-SCFA Nanoparticles" JHU Institute for NanoBioTechnology $25,000 Entire Project dc Role: Co-investigator Effort 1% (no sal) P.I. Kevin Yarema

Training grant participation: NIH NRSA T32CA09574 (P.I.: Stuart Grossman) Updated 10/26/2015

7/1/87-6/30/13

Henry Brem, M.D.

Research Training in Neuro-Oncology"

28

Role: Co- P.I.

(Trainees in the Hunterian Neurosurgical Laboratory) 07/89 - 07/91 Chris Guerin "Angiogenesis" 07/91 - 07/93 Jon Weingart " Angiogenesis, Camptothecin" 07/91 - 07/93 Kwame Buahin " Polymer delivery of BCNU & 4-HC" 07/93 - 07/93 Eric Sipos " Angiogenesis, minocycline, CMTs" 07/93 - 07/95 Reid Thompson "Immunotoxins, cytokines, vasospasms" 07/94 - 07/96 Allan Sills "Steroid release from polymers" and "Squalamine" 07/94 - 07/96 Matt Ewend "Gene therapy" 07/96 - 07/98 Prakash Sampath "Chemo and immuno-therapy" 07/97 - 07/99 Larry Rhines, MD "Resistance modifiers" 07/98 - 07/00 Raymond Haroun "Antiangiogenesis" 07/00 - 06/02 Jay Storm "Camptothecin" 07/01 - 06/03 Paul Wang "Angiogenesis" and "COL-3, COL-8" 07/02 - 07/04 Kyle Weaver "Glutamate transporter" 07/02 - 07/04 Eric Amundson "Camptothecine" and "spinal metastases" 07/05 - 07/07 Khan Li "Combination drug therapy" 07/06 - 07/08 Violette Renard "Efficacy of Camptothecin analogs – preclinical studies" 07/06 - 07/08 Daniel Sciubba "Ultrasound ablation of spine tumor metastases. Gene viral delivery for treatment of spine tumors" 07/08 - 07/10 Wesley Hsu “Isolation of Cancer Stem Cells in Chordoma” 07/09 - 07-11 Gustavo Pradilla Stereotactic Radiosurgery in an Animal Model of Metastatic Spine Disease” 07/09 - 07/11 Chetan Bettegowda “Blood based biomarkers in Cancer” 07/11 - 07/13 Mari Groves "Microchip Implantations in the Brain” NCI NRSA, 5 T32 CA09630-14 (P.I: Z. Bhujwalla) “Research Training in Oncology Imaging”

8/1/89-12/31/2003 Role: Participating Faculty

NCI 2 T32-HL07712-11 (P.I. Paul Bottomley) "Research Training in Interventional Radiology”

7/1/92-6/30/2005 Role: Participating Faculty

NCI 5PP30 CA006973 (P.I.: William Nelson) "Regional Oncology Research Center Grant"

5/1/97-4/30/14 Role: Program Leadership

NCI NIH 5T32EB003383 (P.I.Nitish Thakor) “Neuroengineering Training Grant”

5/1/04-4/30/14 Role: Participating Faculty

NIH 5R25CA153952-04 (P.I. Denis Wirtz) 9/1/10 - 8/10/15 “Training Program in Nanotechnology for Cancer Medicine” Role: Participating Faculty

Editorial Activities: Editorial Board Appointments: Journal of Neuro-Oncology, Associate Editor, 1995 The International Journal of Drug Targeting, 1995 Neurosurgery, 1997 - 2011 Neuro-Oncology, 1998 - 2003 Annals of Surgical Oncology (Section of Neuro-Oncology,) Executive Committee 2002-2005 AACR, Molecular Cancer Therapeutics, 2001 NeuroRx (ASENT), 2002-2005 Annals of Surgical Oncology, 2006-2008 World Neurosurgery, 2010 - present Updated 10/26/2015

Henry Brem, M.D.

29

Neurosurgery, Editorial Advisory Board , 2011 - present Editor: Guest Editor, Journal of Neuro-Oncology (Special Edition: Implant Approach to Chemotherapy), 1995. Section Editor,Youmans Textbook of Neurological Surgery-5th Edition, 2003. Associate Editor, Annals of Surgical Oncology (Section of Neuro-Oncology) 2002-2005. Section Editor, Youmans Textbook of Neurological Surgery-6th Edition, 2011

DEVELOPMENT AND FUNDRAISING ACTIVITIES 2000 - $100,000,000 including ten new endowed professorships and one new Institute. Harvey Cushing Professorship in Neurosurgery Donlin Long Chair in Neurosurgery Irving J. Sherman, M.D. Research Professorship in Neurosurgery Walter Dandy, M.D. Professorship in Neurosurgery Salisbury Family Professorship in Neurosurgery A. Earl Walker, M.D. Professorship in Functional Neurosurgery Benjamin S. Carson, Sr., M.D. and Dr. Evelyn Spiro, R.N. Professorship in Pediatric Neurosurgery The Solomon H. Synder Professorship in Neurosurgery The George J. Heuer Professorship in Neurosurgery The Henry Brem Professorship in Neurosurgery Neurosurgery Pain Research Institute at Johns Hopkins

CLINICAL ACTIVITIES Active Neurosurgical Practice. Neurosurgeon-In-Chief, Johns Hopkins Medical Institutions Built Largest Brain Tumor Center in the United States. Medical Licensure Maryland Board of Physicians Physician & Surgeon, Certification No. D0024362 Board Certification:

American Board of Neurological Surgery - September, 1986

ORGANIZATIONAL ACTIVITIES Institutional Administrative Appointments:

Search Committees for Departmental Chairman 2000 Psychiatry 2001 Surgery 2002 Radiation Oncology 2003 Radiology 2003 Anesthesia and Critical Care (Vice Chairman) 2003 Ophthalmology (Chairman) 2007 Neurology 2007 Oncology 2010 Otolaryngology –Head and Neck Surgery Updated 10/26/2015

Henry Brem, M.D.

2013 2013

30

Pediatric Surgeon in Chief of the Bloomberg Children's Hospital Anesthesia and Critical Care (Chairman)

Johns Hopkins Academic Committees: 1984 - 1994 Johns Hopkins Hospital Tissue Committee 1984 - 1992 Neurosurgery Department: Resident Lecture Series & Journal Club 1984 - 2000 Neurological Intensive Care Unit 1985 - 1986 Dean's Committee on Development of Resources for Clinical Investigators 1985 - 1990 Laser Committee - Johns Hopkins Hospital 1989 - 1993 Johns Hopkins University Medical School Council 1993 - 1995 Clinical Neurosciences Appointments & Promotions Committee 1993 - 1997 Faculty Compensation Ad Hoc Dean's Committee. 1993 - 1995 Clinician Scientist Committee, JHU Sch of Med 1994 - 1995 Johns Hopkins Hospital Cancer Center Project Planning 1994 - 1998 School of Medicine Professorial Promotions Subcommittee 1994 - 2000 Chairman, Neurosurgery Task Force-Faculty Compensation 1994 - 2005 Director, Scientific Research Center; New Approaches to Brain Tumor Therapy (NABTT;NIH,NCI) 1995 - 2000 Associate Professor Promotions Committee, Johns Hopkins SOM 1995 Executive Operating Room Committee 1997 - 1998 Dean’s Committee on Revision of Promotion Guidelines for Johns Hopkins School of Medicine. 1997 - 1998 SOM Service Excellence Task Force Committee. 1998 - 2000 Technology Advisory Group - Office of the Dean 1998 - 2000 Chairman, Neurosurgery Task Force for Laboratory and Operating Room Planning. 2000 Board of Trustees, Johns Hopkins Medicine, Ex offico 2000 - 2002 Budget, Finance & Planning Committee of the Clinical Practice Assoc, JHMI. 2000 - 2003 Professors Promotions Committee, Johns Hopkins, SOM 2000 Surgical Sciences Chiefs Committee 2000 - 2005 Length of Stay Initiative 2000 - 2005 Casemix/Clinical Documentation Committee 2000 Clinical Directors Committee, JHH 2000 Johns Hopkins Hospital Medical Board 2000 Advisory Board of Medical Faculty, JHUSOM 2000 - 2007 Director, Neurosurgery Residency Program 2000 - 2007 Joint Committee on Graduate Medical Education and Postdoctoral Programs 2001 - 2003 Conflict of Interest Policy Review Committee, JHUSOM 2001 - 2010 Board of Governors, Clinical Practice Association, JHUSOM. 2002 - 2005 Johns Hopkins Medicine Committee on Faculty Development and Gender 2002 Innovation in Quality Patient Care Steering Committee 2002 Advisory Council, Sidney Kimmel Comprehensive Cancer Center 2002 - 2010 Chairman, Budget, Finance & Planning Committee of the Clinical Practice Association 2003 - 2005 Agenda Committee of the Advisory Board of Medical Faculty – JHUSOM 2003 - 2005 Cancer Research Building Planning Council 2003 Technology Opportunities Program Committee, JHUSOM 2007 Advisory Board, Brain Science Institute, JHUSOM. 2009 Planning Committee & University Council – Brain Science Institute, JHUSOM 2009 Johns Hopkins Prize Committee 2009 Inpatient Flow Executive Team for Johns Hopkins Hospital 2011- 2012 Director’s Committee for Quality and Safety, Johns Hopkins Medicine, Chair 2011Armstrong Institute for Patient Safety and Quality, Physician Leadership in Quality and Care Delivery, Co-Chair 2011Armstrong Institute for Patient Safety and Quality Transition Team 2011Bed Management and Reallocation Opportunities, Johns Hopkins Health Services Updated 10/26/2015

Henry Brem, M.D.

20112011201120122012 - 2013 2012 - 2014 2012 -

31

Workgroups, Team Leader. Coulter Foundation Oversight Committee Clinical Director’s SOM, Safety Initiative JHM Operating Committee JHU Space Committee Chairman, Internet and Digital Brand Management Advisory Committee Chairman, LCME Institutional Setting Subcommittee for Accreditation Site Visit Neurofibromatosis Therapeutic Acceleration Program (NTAP) Johns Hopkins Oversight Committee

PROFESSIONAL SOCIETIES:

National Committees: 1988 - 1993 Preuss Research Award Selection Committee 1989 - 1990 Scientific Committee for the Convention of Congress of Neurological Surgeons 1990 Brain Tumor Research Subcommittee for the Joint AANS/CNS 1992 Surgical Committee of the Radiation Therapy Oncology Group RTOG) 1996 National Comprehensive Cancer Network (NCCN) Central Nervous Systems Cancer Panel (2011-) 1999 American College of Surgeons-Oncology Group, Brain/Central Nervous System Organ Site Committee Physician Group (Member ID 378; Group ID 162) 2001 Liaison to the National Cancer Institute for the American Association of Neurological Surgeons Board of Directors 2002 - 2009 Neurosurgery Research and Education Foundation, Executive Council Member 2003 Institute of Medicine, National Academy of Sciences: IOM Membership Committee, Vice-Chair, Section 1 (2003-2005) IOM, Membership Committee, Chair, Section 1 (2005-2007) IOM, Nomination Committee, (2011-) 2005 Society of Neurological Surgeons, Research Updates in Neuroscience for Neurosurgeons (RUNN) at the Marine Biological Laboratory, Woods Hole, Massachusetts. RUNN Course Co-Director RUNN Curriculum (Subcommittee) 2007 B.R.A.I.N. (Brain Research Academy International for Neoplasia) founding member 2007 American Academy of Neurological Surgery, Scientific Program Chair -69th Annual Meeting, Lake Las Vegas, Henderson, Nevada Oct 31-Nov 3, 2007. 2007 Society of Neurological Surgeons – Committee on Resident Education (CoRE). 2009 NYU in DC Committee - New York University Alumni.

Conference Organizer, Session Chair: American Academy of Neurological Surgeons, Oct 31-Nov 3, 2007, Scientific Program Chair.

Advisory Committees, Review Groups:

Scientific Advisory Committees: 1997National Brain Tumor Foundation, San Francisco Updated 10/26/2015

Henry Brem, M.D.

19972011 2011201120112012-

32

Brain Tumor Society, Boston, MA Doris Duke Charitable Foundation San Francisco Research Fellowship at Johns Hopkins Brain Science Institute Neurotranslational Program Armstrong Executive Committee FDA Medical Devices Advisory Committee The European Association of Neurosurgical Societies

N.I.H. Study Section – Reviewer: Surgical Training Program Grants, Washington, DC, Ad Hoc Committee UCSF - Brain Tumor Center Ohio State University - Brain Tumor Cooperative Group

Feb 17, 1993 Oct 20-22, 1993. Apr 22, 1994

Selected Grant Reviews: 1. North Carolina Biotechnology Center Economic Development Financial Grants Program. Spartaject Formulations of Natural Produce Anti-Cancer Agents." November 1994. 2. Breast Cancer Research Programs - California Cancer Fund. "Angiogenesis and Growth Control." May 1995. 3. The Brain Tumor Society Scientific Advisory Council, Boston, Massachusetts, 1997-2001 4. National Brain Tumor Foundation. 19975. American Cancer Society – 2000 6. The Skolkovo Institute of Science and Technology SkTech/MIT Initiative. 2012-

Consultantships:

Scientific Advisory Boards: 1991 - 2001 1993 - 1996 1994 - 1997 1995 1995 - 1999 1996 - 2002 1997 - 2000 1997 - 2003 1998 - 2000 1998 - 2000 1999 - 2001 2000 - 2005 2000 - 2005 2001 2001 2003 2004 - 2006 2005 - 2009 2005 2005 2010 2014 2014 Updated 10/26/2015

Focal, Inc., Lexington, Massachusetts Boston Life Sciences, Inc., Waltham, Massachusetts Polykinetix, Inc., New York, New York International Cancer Alliance, Bethesda, Maryland EnzyMed, Inc., Iowa City, Iowa Orasomal, Technologies, Inc., Lake Bluff, Illinois Astra Merck Neuroscience Advisory Board Glioma Outcomes Program Advisory Board Rhone-Poulenc Rorer Oncology Advisory Board Medical Programs Incorporated EntreMed, Inc., Oncology Advisory Board Guilford Pharmaceuticals, Inc., Baltimore, MD (founding scientist) GMP Companies, Inc. PureTech Ventures, LLC Accelerate Brain Cancer Cure (ABC2) CytoDome, Inc, Dunwoody, GA. MacroMed, Inc., Sandy UT Day Casebeer Madrid & Batchelder LLP, Cupertino, CA (consultant) BrainsGate, Ltd, Israel Northwest Biotherapeutics, Inc, Bothell, WA Voices Against Brain Cancer StemGen. Milano Italy AsclepiX Therapeutics

Henry Brem, M.D.

33

Board of Directors: 1991 - 2001 Focal, Inc., Lexington, MA 1997 - 2000 Carson Scholarship Foundation, Baltimore, MD 1999 - 2004 Beth Tfiloh Day School, Baltimore, MD 2000 JHU Technion Joint Program 2003 - 2005 Ben Fund, Baltimore, MD 2007 - 2010 Alseres Pharmaceuticals, Inc. 2009 Maryland/Israel Development Center 2015 Jerusalem College of Engineering, Board of Trustees

RECOGNITION

Awards, honors: 1970 1972 1973 1975 1978 1980 1985 1985 1987 1990 1995 1995 1996 1996 1997 1998 1998 2000 2000 2000 2001 2002 2004 2004 2004 2005 2005 2005 2005 2005 2005 2007 2008 2009 2010 2010 2010 2010 2010

Marmorosh Award for Academic Achievement Rubin Award in Basic Medical Sciences (NYU) Coat of Arms Honor Society of NYU Salem Award for Outstanding Academic Accomplishment and Highest Honors in Biology (NYU) Saul R. Korey Award for Experimental Neurology (American Academy of Neurology) Honors in a Special Field, Harvard Med School Resident Award of the New York Society of Neurosurgery Neurosurgery Award for Distinction in Teaching, Johns Hopkins University Clinical Investigator Development Award, NIH Clinician-Scientist Award, Johns Hopkins University Fellow, American College of Surgeons Clemson Award for Applied Research, Society for Biomaterials. Walter E. Dandy Visiting Professorship, JHU Professor’s Award for Excellence in Teaching, JHU Altman Lectureship, University of Pennsylvania Fellow, American Institute for Medical and Biomedical Engineering. High Technology Award (for Gliadel), The Technology Council of Maryland. Institute of Medicine, National Academy of Sciences. Neurosurgery Department Ranked #3 by U.S. News and World Report International Fellow of Biomaterials Science and Engineering (FBSE), Society for Biomaterials. Grass Foundation Award of the Society of Neurological Surgeons. Founders’ Award, Controlled Release Society Castle Connolly America’s Top Doctors, Castle Connolly Guide Neurosurgery Department Ranked #2 by U.S. News and World Report New York University Distinguished Alumni Award Baltimore Monthly Medical Reunion Dinner Club 2005 Technology Innovation and Development Award of the Society for Biomaterials E. Llewelyn Thomas lecturer, The Institute of Biomaterials and Biomedical Engineering, Toronto, CA Tocqueville Society of The United Way of Central Maryland The Noun Shavit Memorial Lecturer, Ben-Gurion University, Beer Sheva, Israel. Coleman Fellow in Life Sciences, Ben-Gurion University, Beer-Sheva, Israel Castle Connolly America’s Top Doctors for Cancer, Castle Connolly Guide Rosomoff Visiting Professor, Department of Neurosurgery, University of Miami, Miami, Florida. Visiting Professor, Cedars-Sinai Medical Center, Los Angeles, CA. Henry A. Shenkin, MD Lecture, Temple University, Philadelphis, PA. Faculty Inductee, Alpha Omega Alpha Honor Medical Society Neurosurgery Department Ranked #1 by U.S. News and World Report Van Wagenen Professor, University of Rochester Medical Center, Rochester, NY. Gary Lichtenstein Humanitarian Award, Voices Against Brain Cancer Tenth Annual Hugo V. Rizzoli, M.D. Lecturer, Walter Reed Army Medical Center & National Naval

Updated 10/26/2015

Henry Brem, M.D.

2011 2011 2012 2012 2013 2013 2014 2014 2015 2015

34

Medical Center, National Capital Neurosurgery. Commencement Address, Johns Hopkins University School of Medicine Seventh Annual Stuart Rowe Society Lecturer, University of Pittsburgh, Department of Neurosurgery Boy Scouts of America, Health Leadership Award Castle Connolly Magazine, Top Doctors: Washington-Baltimore The Michael S. Voynick Lecture in Neuro-Oncology Award, Yale School of Medicine, New Haven, CT The Abitjit Guha Award and Lecture Johns Hopkins Medicine International Community Service Award, Chabad at Johns Hopkins Henry Brem Endowed Chair in Neurosurgery, Johns Hopkins University Castle Connolly National Physician of the Year Award for Clinical Excellence National Academy of Medicine

Invited Talks, Panels: 1. Seminar, Graduate Department of Psychology, New York University. "Role of Cyclic AMP in the Nervous System." April 3, l973. 2. Seminar, Graduate Department of Biology, N.Y.U. "Membrane Changes and Regulation of DNA Synthesis." April 24, l973. 3. Second International Catalina Colloquium on Extracellular Matrix Influences on Gene Expression Cartilage Mediated Inhibition of Tumor Angiogenesis." Sept 23, l974 4. Soma Weiss Award Assembly, Harvard Medical School, Boston, MA. "Inhibition of Tumor Angiogenesis is Mediated by Cartilage." May 13, l975. 5. Surgical Grand Rounds, West Roxbury V.A. Hospital. "Tumor Angiogenesis." January 13, l977. 6. Medical Grand Rounds, Brockton V.A. Hospital. "Control of Tumor Angiogenesis." May 3, l977. 7. Association for Research in Vision and Ophthalmology, Sarasota, Florida. "Vitreous Inhibition of Tumor Neovascularization." April 26, l977. 8. Seminar, Department of Medicine, Massachusetts General Hospital. "Inhibition of Neovascularization as a Control of Tumor Growth." June 22, l977. 9. Lecture, Wilmer Institute, Johns Hopkins School of Medicine. "Progress in Controlling Tumor Angiogenesis." June 14, l977. 10. Soma Weiss Award Assembly, Harvard Medical School, Boston, MA. "Control of Neovascularization." May l8, l978. 11. Plastic Surgery Department, Children's Hospital Medical Center and the Peter Bent Brigham Hospital, Boston, MA. "Clinical Observations and Basic Science." July 28, l978. 12. Lecture, Workshop in New Research in Diabetic Retinopathy, Boston, Mass. "Cartilage Mediated Inhibition of Neovascularization." September 15, l978. 13. Society of University Surgeons, University Surgical Resident's 21stAnnual Conference in Salt Lake City, Utah. "One year Administration of Oral Norepinephrine and Methoxyamine to Control G.I. Bleeding from Recurrent A-V Malformations." February 15, l979. 14. Faculty Course in Cervical Neoplasia, Hospital General de Mexico, Mexico City. "Angiogenesis." April 12, l979. 15. Surgical Grand Rounds, Peter Bent Brigham Hospital, Boston, MA. "Control of Tumor Growth." May 12, l979. 16. Sixth National Science Writers Seminar of Research to Prevent Blindness, Los Angeles, California. "Progress In Controlling Retinal Neovascularization." October 8, l979. 17. Conference on Diabetic Retinal Syndrome, Downstate Medical Center, New York. "Control of Neovascularization." November 12, l979. 18. New York Society of Neurosurgery. "Inhibition of Angiogenesis: Significance for Human Brain Tumors" Award Lecture. March 11, l980. 19. Association for Research - Vision and Ophthalmology, Orlando, Florida. "Corneal Inflammation Induced by a Purified Lymphokine." May 9, l980. 20. Clinical Congress of the American College of Surgeons, Atlanta, Georgia. "Human Brain Tumors: Differences in Ability to Stimulate Angiogenesis. October 22, l980. 21. Conference on Diabetic Renal-Retinal Syndrome II, Downstate Medical Center, New York. "Controlling Updated 10/26/2015

Henry Brem, M.D. - 35

22. 23. 24.

25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46.

47. 48. 49. 50. 51. 52.

Blood Vessel Proliferation." Nov., l98l. The Fellowship of Academic Neurosurgeons, XIII Annual Meeting, New York. "Angiogenesis Theory." March 11, l983. American Association of Neurological Surgeons, Washington, Dc "Detection of Human Brain Tumors: An In Vitro Method Utilizing CSF." April 27, l983. Clinical Congress of the American College of Surgeons, Atlanta, GA. "Detection of Human Central Nervous System Tumors: Use of Migration Stimulating Activity of the Cerebrospinal Fluid. October 19, l983. Congress of Neurological Surgeons, Chicago, Illinois. "Brain Tumor Angiogenesis." October 28, l983. Neurology Grand Rounds, Johns Hopkins Hospital. “Brain Tumor Angiogenesis.” September 20, 1984. Lecture, Johns Hopkins University School of Medicine, Symposium on Temporal Bone Surgery." Nov. 910, 1984. Ophthalmology Grand Rounds, Wilmer Ophthalmological Institute, JHH.b"Retinal Signs and Symptoms of Carotid Artery Disease." November 21, l984. Pediatric Neuro-Oncology Conference, Johns Hopkins Hospital. "New Approaches in Brain Tumor Therapy." December 12, l984. Surgical Grand Rounds, Johns Hopkins Hospital. "Hemangioblastomas and Angiogenesis." December 1984. Oncology Grand Rounds, Johns Hopkins Hospital. "Neovascularization of Brain Tumors." January 10, l985. General Surgery Grand Rounds, St. Agnes Hospital, Baltimore, MD. "Advances in the Diagnosis and Treatment of Brain Tumors." January 16, l985. Neurology Grand Rounds, Johns Hopkins Hospital. "Extracranial-Intracranial Bypass Grafting for Cerebral Ischemia." Mar.7, l985. NINCDS SNB, NIH, Bethesda, MD. "Brain Tumor Angiogenesis." April 12, l985. Pathology Lecture, Johns Hopkins Hospital. "Tumor Vasculature." April 16, l985. Lecture, The Johns Hopkins Medical and Surgical Association. "Angiogenesis Factor and its Potentials for Therapy in Brain Tumors."Jun14, l985 Medical Grand Rounds, Francis Scott Key Medical Center, Baltimore, MD. "Treatment of Brain Tumors." January 15, l986. Lecture, Johns Hopkins Medical Institutions, Skull Base Tumor Course. "Tumors of the Foramen Magnum." February 8, l986. Lecture, Johns Hopkins University, Acute Care in Neurology and Neurosurgery. "New Approaches to Treatment of Brain Tumors." April 4, l986. Lecture, Johns Hopkins University, Department of Rehabilitation Medicine. "Management of Aneurysms and Vascular Malformations. May l9, l986. Surgery Grand Rounds, Johns Hopkins Hospital. "Metastatic Spinal Disease." March 7, 1987. Science Writers Conference on Brain Cancer. March l8, 1987. Lecture, Johns Hopkins University, Topics in Clinical Medicine 1987. "Pituitary Lesions." May 15, 1987. Lecture, Society of University Neurological Surgeons. "Human Brain Tumor Angiogenesis: drug delivery by bioerodible materials." May 29, 1987. Lecture, The Johns Hopkins Medical and Surgical Association. "Angiogenesis in Human Brain Tumors." June 12, 1987. Lecture, The Johns Hopkins Medical Institutions. Interventional Neuroradiology: Current Practices and Techniques. "Treatment of Intracranial Angiofibromas and Chemodectomas." "Embolization and Surgical Management of Meningiomas." December 9, 1987. Lecture, The Johns Hopkins Medical Institutions, PET Scanning Course. "PET Scanning of Brain Tumors." March 18, 1988. Visiting Professor, Columbia College of Physician and Surgeons, New York, NY. "Advances in NeuroOncology." June 30, 1988. Lecture, 6th Gordon Research Conference on Drug Carriers in Biology and Medicine, Plymouth, NH. "Clinical Studies: Bioerodible Polyanhydrides for Brain Disorders." July 13, 1988. Lecture, Joint Tumor Section Program of the Congress of Neurological Surgeons, Seattle, WA. "Tumor Angiogenesis." September 26, 1988. Lecture, Johns Hopkins University Medical School, Basic Surgical Clerkship Lecture Series. "Brain Tumors." Quarterly, 1988 - 1990. Lecture, Association of Government Toxicologists. Rockville, MD."Implants." Oct. 27, 1988.

Updated 10/26/2015

Henry Brem, M.D. - 36

53. Lecture, University of Pennsylvania, Visiting Professor. Interstitial Chemotherapy for Brain Tumor Angiogenesis." March 9-10, 1989. 54. Lecture, Peripatetic Club, 52nd Annual Meeting, Baltimore, MD. "Biodegradable Polymers as Vehicles for Therapeutic Agents." March 31, 1989. 55. Seminar, The American Association of Neurological Surgeons, Washington, D.C. "Intralesional Therapies for Malignant Gliomas." April 6, 1989. 56. Lecture, Neurosurgery Grand Rounds, Christiana Hospital, Newark, DE. "Advances in Neuro-Oncology." May 18, 1989. 57. Lecture, Johns Hopkins Hospital Centennial, Baltimore, MD. "Neuro-oncology." June 6, 1989 58. Lecture, NATO ASI, Cape Sounion, Greece, Targeting of Drugs: Optimization Studies. June 24-July 5,1989. 59. Lecture, Controlled Release Society, Chicago, IL. "Controlled Delivery to the Brain." August 7, 1989. 60. Lecture, Review and Update in Neurobiology for Neurosurgeons, Woods Hole, Massachusetts. "Biodegradable Polymers." November 11, 1989. 61. Lecture, Tables Rondes Roussel-UCLAF, Paris, France. "Delivery of Drugs to the Brain by Use of Sustained-Release Polyanhydride Polymer System." Dec 7, 1989. 62. Lecture, Stockholm, Sweden. "Clinical Trials of Controlled Release Polymers." December 10, 1989. 63. Lecture, McGill University - Neuroscience Symposium, Montreal, Quebec, Canada. "Biodegradable Polymers to Treat Brain Tumors." January 10, 1990. 64. Lecture, Johns Hopkins Hospital, Surgery Grand Rounds. "Intraoperative Drug Delivery." March 10, 1990. 65. Plenary Lecture, American Chemical Society, Boston, MA. "The Development of Polyanhydrides to Treat Brain Tumors." April 26,1990. 66. Lecture, Research Society of Neurological Surgery, Boston, MA. "Brain Tumor Angiogenesis." June 14, 1990. 67. Visiting Professor, Georgetown University School of Medicine, Neurosurgery Grand Rounds, Washington, D.C. "New Approaches to Treating Brain Tumors." Jun 20, 1990 68. Visiting Professor, Chicago Neurological Center. "The Development of Local Therapy for Brain Tumors." July 9, 1990. 69. Lecture, Johns Hopkins Hospital, Surgery Grand Rounds. "Progress in the Treatment of Pituitary Tumors." October 13, 1990 70. Visiting Professor, Robert Wood Johnson Medical School, New Brunswick, New Jersey. "New Approaches to Treat Brain Tumors" November 28, 1990. 71. Lecture, Recent Advances in Drug Delivery systems Symposium, Salt Lake City, UT. "Polymeric Drug Delivery Systems in the Treatment of Brain Diseases." February 28, 1991. 72. Lecture, International Symposium on Angiogenesis, St. Gallen, Switzerland, "Drug Delivery to the Brain and Angiogenesis Inhibition." March 13, 1991. 73. Lecture, The Preuss Foundation Seminar on Pharmacologic Problems in the Treatment of Glial Tumors, Durham, NC. April 16, 1991. 74. Lecture, Research Society of Neurological Surgeons, Durham, NC. "Drug Delivery to the Brain Utilizing Biodegradable Polymers." May 3, 1991. 75. Plenary Lecture, American Association of Cancer Research, Houston, TX. "Interstitial Chemotherapy Utilizing Polymers for Treating Brain Tumors." May 17, 1991. 76. Lecture, Johns Hopkins University Joint Neurology/Neurosurgery Biennial Meeting. "Polymers for Treatment of Brain Tumors." June 7, 1991. 77. Lecture, Johns Hopkins University Surgical Symposium. "New Approaches to the Treatment of Brain Tumors." June 7, 1991. 78. Lecture, International Conference on Biomaterials, Jerusalem, Israel. "Biodegradable polymer implants to release drugs in the treatment of brain disease." June 9, 1991. 79. Lecture, The Ninth International Conference on Brain Tumor Research and Therapy, Asilomar, CA. "Interstitial chemotherapy.” October 16, 1991. 80. The Chicago Institute for Neurosurgery and Neuroresearch, Basic Neurooncology Symposium. "Biodegradable Polymers for Brain Tumor Treatment." Nov 9, 1991. 81. US-Japan Conference on Drug Delivery Systems, Maui, Hawaii. "Controlled Drug Delivery Systems for the Brain." Dec 16, 1991. 82. Lederle Laboratories, Dept of Molecular Biology, NY. "Mechanism of Tetracycline Inhibition of Angiogenesis." January 28, 1992. Updated 10/26/2015

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83. Department of Chemical Engineering, M.I.T. "Polymer Development." February 24, 1992. 84. Neurology Lecture Series, Johns Hopkins Hospital. "Control of Angiogenesis.” February 25, 1992. 85. Co-Chairman, Preuss Foundation Symposium. Dallas, TX. "Delivery of Treatment to Brain Tumors." March 12-13, 1992. 86. American Chemical Society, San Francisco, CA. "Controlled Release Polymers to Deliver Drugs to the Brain." April 8, 1992. 87. Second Jerusalem Conference on Pharmaceutical Sciences and Clinical Pharmacology, Jerusalem, Israel. "Drug Delivery to the Brain." May 29, 1992. 88. Neurology and Oncology Grand Rounds, Jerusalem, Israel. "New Developments in Brain Tumor Treatment." May 31, 1992. 89. Gordon Research Conference on Drug Carriers in Biology and Medicine, New Hampshire. "Polymer Controlled Delivery to the Brain." July 6, 1992. 90. American Association of Colleges of Pharmacy (AACP), Washington, D.C. "Biodegradable Implants for Brain Cancer." July 12, 1992. 91. Controlled Release Society Symposium, Orlando, FL. "Controlled Delivery Systems for the Brain." July 31, 1992. 92. Visiting Professor, Polish Academy of Sciences, Warsaw, Poland. "New Approaches to Intracranial Edema." August 21, 1992 93. Strategic Alliances with Industry, Greater Baltimore Committee's High Tech Assembly, Baltimore, Maryland. "Surgery, Drug Delivery and Computer Visualization." October 21, 1992. 94. Congress of Neurological Surgeons, Washington, D.C. "Pharmacological Surgical Implants for Brain Tumor Therapy." November 2, 1992. 95. Visiting Professor, Ohio State University, Department of Surgery. "Local Delivery of Chemotherapeutic Agents for the Treatment of Cancer." November 7, 1992. 96. International Congress on Advances in Brain Revascularization, Eilat, Israel. "Polymers as Controlled Drug Delivery Systems for the Brain." April 22, 1993. 97. American Association for Neurological Surgeons, Boston, MA. "New Windows in Glioma Treatment." April 27, 1993. 98. Third Drug Discovery and Development Symposium, San Diego, CA. "Local Drug Delivery to Tumor using Polymer." July 24, 1993. 99. Congress of Neurological Surgeons, Vancouver, British Columbia. "Intestitial Chemotherapy for Brain Tumors.” October 4, 1993. 100. American Academy of Neurological Surgery, Phoenix, AZ. "Polymers as an Intracranial Implantable Controlled Drug Delivery System." October 30, 1993. 101. Harvard Medical School - Continuing Education Medical Course, Boston, MA. "Delivery Systems for Brain Tumor Therapy." November 11, 1993. 102. UCLA Division of Neurosurgery, Advances in Brain Tumor Management Symposium, Marina del Rey, CA. "Biodegradable Polymers for Drug Delivery" and "Antiangiogenesis Therapy." November 20, 1993. 103. The 2nd US-Japan Symposium on Drug Delivery, Maui, HI. "Neural Applications of Controlled Delivery Devices." December 1993. 104. The New York Academy of Sciences Symposium, Tampa, FL. "Biodegradable Polymers for Neurological Applications." January 21, 1994. 105. Pet and Spect Imaging in Oncology, Johns Hopkins Medical Institutions, Baltimore, MD. "Therapeutic Decisions in Patients with Brain Tumors." March 9, 1994. 106. The Society of Surgical Oncology, Houston, TX. "Polymers as an Intracranial Implantable Controlled Drug Delivery System." March 19, 1994. 107. The American Association of Neurological Surgeons, San Diego, CA. "Novel Treatments for Malignant Gliomas." April 14, 1994. 108. The American Society of Clinical Oncology, Dallas, TX. "Intraoperative Chemotherapy using Biodegradable Polymers: Safety and Effectiveness for Recurrent Glioma Evaluated by a Prospective, Multi-Institutional Placebo-Controlled Clinical Trial.” May 17, 1994. 109. The Controlled Release Society, Nice, France. "Polymers as an Intracranial Implantable Controlled Drug Delivery System." June 28, 1994. 110. Congress of Neurological Surgeons, Chicago, IL. "Intraoperative Chemotherapy Using Biodegradable Polymers by a Prospective, Multi-institutional Placebo-Controlled Trial for Safety and Effectiveness.” Updated 10/26/2015

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111. 112. 113. 114. 115. 116.

117. 118. 119. 120. 121. 122.

123. 124. 125. 126. 127. 128.

129. 130. 131. 132. 133. 134. 135. 136. 137.

October 5, 1994. Multidisciplinary Clinical Conference, Johns Hopkins Oncology Center "Local Delivery of Chemotherapy for Brain Tumors." October 20, 1994. The Neurological Institute Association of the Alumni, Columbia University, NY. "New Horizons in Brain Tumor Therapy: From Laboratory to Bedside." December 1, 1994. Seattle Glioblastoma Workshop, Seattle, Washington. "Polymer Systems for Drug Delivery to Brain Tumors." Dec 10-11, 1994. The Keystone Symposia on Molecular & Cellular Biology, Hilton Head, SC. "Drug Delivery for Brain Tumors." January 11, 1995. UCLA Symposium on Advances in Brain Tumor Management, Las Vegas, NV. "Biodegradable Polymers" and "Angiogenesis." Feb 18, 1995 Visiting Professor, Harvard Medical School, Boston, MA: Children's Hospital, Neurosurgery Grand Rounds, "Local Therapy for Brain Tumors Utilizing Biodegradable Polymers," and Brigham & Women's Hospital, Neuroscience Seminar, "Minocycline for Inhibition of Brain Tumor Angiogenesis." March 2, 1995. Neuroscience Medical Student Course, Johns Hopkins University School of Medicine. "Brain Tumors." March 3, 1995. Walter E. Dandy Visiting Professor, Baltimore, MD. "Treatment of Brain Tumors: Past, Present and Future." March 9, 1995. 1995 Clemson Award Recipient for Biomaterials Research, Society for Biomaterials, San Francisco. "Polymeric Drug Delivery to the Brain." March 19-23, 1995. American Association of Neurological Surgeons, Orlando, FL. "Current and Novel Treatments of Malignant Gliomas." April 27, 1995. M.I.T. Chemical Engineering Lectureship, Cambridge, MA. "New Medical Technologies." May 8, 1995. Visiting Professor, University of Calgary, Calgary, Alberta, Canada. "Biodegradable Polymers for Local Therapy of Brain Tumors--From Laboratory to Clinical Trials," and "Minocycline for Inhibition of Brain Tumor Angiogenesis." May 19, 1995. The Johns Hopkins Medical & Surgical Association Biennial Meeting, Baltimore, MD. "New Approaches to Brain Tumor Therapy." June 9, 1995. American Chemical Society, Conference on Formulations and Drug Delivery, Boston, Massachusetts. "Polymer Systems for Drug Delivery to the Brain." October 12, 1995. Congress of Neurological Surgeons, San Francisco, CA "Treatment of Recurrent Gliomas." October 16, 1995. American Neurological Association, Washington, DC. "Clinical Trials of Brain Tumor Therapy." Oct 23, 1995. Society of Surgical Chairmen, Washington, DC. "Craniotomy Outcome Analysis." October 29, 1995. Eleventh International Conference on Brain Tumor Research and Therapy, Napa, California. "Controlled Delivery of Chemotherapy by Biodegradable Polymers for the Treatment of Malignant Gliomas." Nov 1, 1995. American Academy of Neurological Surgeons, Tucson, Arizona. "Surgically Implanted Biodegradable Polymers for the Treatment of Malignant Gliomas." Nov 4, 1995. Visiting Professor, Neurology Grand Rounds, Johns Hopkins University, Baltimore, Md. "Drug Delivery to the Brain." November 9, 1995. Controlled Release Society - 3rd US-Japan Symposium, Maui, HI. "Novel Delivery Therapies for Cancer." Dec 17-22, 1995. American Association for the Advancement of Science, Baltimore, MD. "Polymeric Delivery Systems to the Brain." Feb 11, 1996. Sandra Altman Memorial Lecture, University of Pennsylvania, Philadelphia, PA. "Novel Treatments for Brain Tumors." February 29, 1996. Neuroscience Teaching Course, Johns Hopkins School of Medicine, Baltimore, MD. "Clinical Correlation." March 1, 1996. Neuropathology Teaching Course, Johns Hopkins School of Medicine, Baltimore, MD. March 4, 1996. Neurology Grand Rounds, University of Maryland, Baltimore. MD. "Local Therapy of Brain Tumors." March 13, 1996. Ethical Dilemmas in Contemporary Surgery, Johns Hopkins Medical Institutions, Baltimore, MD. "The Education of Surgeons and the Surgical Dabbler: The Ethics of Referral." March 23, 1996.

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138. PET and SPECT Imaging in Cancer Diagnosis and Treatment, Baltimore, MD. "The Problem: Care of Patients with Brain Tumors." March 27, 1996. 139. Howard University Cancer Center, Seminars in Oncology, Washington, DC. "Chemotherapeutic Implants for Malignant Brain Tumors." April 18, 1996. 140. Johns Hopkins University, Department of Medicine, Baltimore, MD. "New Approaches to Brain Tumor Therapy." April 27, 1996. 141. American Association of Neurological Surgeons, Minneapolis, MN. "Polymeric Delivery systems to Treat Brain Tumors: Current Clinical Status and Future Studies." May 2, 1996. 142. Visiting Professor, University of Cincinnati, Cincinnati, OH. "Inhibition of Brain Tumor Angiogenesis." June 18, 1996. 143. "Novel Treatments of Brain Tumors." June 19, 1996. 144. 3rd Jerusalem conference on Pharmaceutical Sciences and Clinical Pharmacology, Jerusalem, Israel. “Polymeric Delivery to the Brain: Laboratory and Clinical Studies.” September 4, 1996. 145. Congress of Neurological Surgeons, Satellite Symposium, Joint Section on Tumor, Montreal, Canada. “Molecular Therapy.” October 4, 1996. 146. Johns Hopkins University, Neuroscience, The Neurosurgeon in Society Program. “Introduction of New Therapies.” October 31, 1996. 147. Medical College of Pennsylvania and Hahnemann University Symposium on Malignant Brain Tumors: Future Directions. "Chemotherapy: New Strategies to By-pass the Blood Brain Barrier.” November 9, 1996. 148. Johns Hopkins University, Department of Chemistry, Homewood Campus, Baltimore, MD. Colloquium Series Seminar. “Drug Delivery to the Brain.” Nov 12, 1996. 149. Training Program for GliadelR Usage, Rhone-Poulenc Rorer, Dallas, TX. Dec 10 and Dec 16, 1996. 150. 18th Annual Eino Nelson Memorial Conference, Aventura, FL. “Localized Controlled Delivery of Chemotherapy for Brain Tumors.” Jan 7, 1997. 151. European Association of Neurological Surgeons, Paris, France. “Defining a Standard for Local Therapy of Gliomas.” February 1, 1997. 152. Neuroscience Medical School Course, Johns Hopkins University, Baltimore, MD. “Clinical Correlations.” February 28, 1997. 153. The Neurosurgeon in Society Program, Johns Hopkins Department of Neurosurgery. “After Cushing and Dandy,” April 3, 1997. 154. Visiting Professor, University of Florida, Tampa, FL “New Approaches to Brain Tumor Therapy,” April 4, 1997. 155. Visiting Professor, The Moffitt Cancer Center, Tampa, FL. “Controlled Sustained Release Polymers to Deliver Cancer Therapy,” April 4, 1997. 156. Medical Technology Assessment Course, Johns Hopkins School of Public Health, Baltimore, MD. “Assessing New Technologies.” April 11, 1997. 157. American Association of Neurological Surgeons, Denver, CO. Seminar Moderator, “Current and Novel Treatment of Malignant Gliomas.” April 17, 1997. 158. West Coast Advisory Panel on Brain Tumor Therapy, Laguna Beach, CA. “Role GliadelR in Treating Brain Tumors.” April 19, 1997. 159. American Association of Pharmaceutical Scientists Western Regional Meeting, San Francisco, CA. “Drug Delivery to the Brain Using Biodegradable Polymers.” April 24, 1997. 160. The 6th Meeting of the Scandinavian Glioma Group, Espoo, Finland. “Local Chemotherapy of Gliomas.” May 15, 1997. 161. American Society of Hospital Pharmacists, Minneapolis, MN. “New Treatments for Brain Disease.” June 5, 1997. 162. Johns Hopkins Medical and Surgical Biennial Meeting, Baltimore, MD., “Advances in Brain Tumor Therapy.” June 6, 1997. 163. Fourth Anticancer Drug Discovery Symposium, Annapolis, Maryland. “Polymeric Local Delivery of Therapeutic Agents to Treat Brain Tumors.” August 5, 1997. 164. Bundesinstitut for Arzneimittel und Medizinprodukte (BfArM), Berlin, Germany. “Clinical Experience with BCNU-polymers.” August 6, 1997. 165. American Academy of Otolaryngology-Head and Neck Surgery, San Francisco, CA. “Cerebrospinal Fluid and Cerebral Vasculature Dynamics in Skull Base Surgery.” Sept 10, 1997. 166. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD. “Treatment of Brain Updated 10/26/2015

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167. 168. 169. 170. 171. 172. 173. 174. 175. 176. 177. 178. 179. 180. 181. 182. 183.

184. 185. 186.

187. 188. 189. 190. 191. 192. 193. 194.

Tumors Utilizing Controlled Drug Delivery.” September 19, 1997. Localized Treatments for Brain Cancer Symposium, New Orleans, LA. “Chemotherapeutic Wafer Implant after Glioma Surgery.” September 29, 1997. Johns Hopkins School of Medicine, Neurosurgeon In Society Program, Baltimore, MD. “Pituitary Tumors.” October 9, 1997 Visiting Professor, University of Chicago, Chicago, IL. “New Approaches to Brain Tumor Therapy.” October 17, 1997. New Jersey Neurological Society, Short Hills, NJ. “Interstitial Chemotherapy for Brain Tumors.” November 3, 1997. Medicines Control Agency, London, England. “Clinical Trial Results with GliadelR.” Nov 7, 1997. Seminaire Franco-Mexicain de Neurologie et de Neuroradiologie, Hospital de la Salpetriere. Paris, France. “Clinical Experience with GliadelR Wafer in Glioblastoma.” November 13, 1997. NYU Post-Graduate Medical School Course (A Systems Approach to Glial Neoplasms), New York, NY. “The Future of Interstitial Chemotherapy”. November 14, 1997. Medical Grand Rounds, Johns Hopkins School of Medicine. “New Approaches to Drug Delivery in the Brain.” November 21, 1997. French Regulatory Agency, Paris, France. “GliadelR to Treat Malignant Glioma.” November 26, 1997. 4th US-Japan Symposium on Drug Delivery Systems, Kauai, HI. “Polymers for the Development Brain Tumor Vaccines.” December 14, 1997. Visiting Professor, University of Tennessee, Memphis, TN. “Development of New Treatment Approach for Brain Tumors.” February 6, 1998. Astra Merck Neuroscience Seminar, Phoenix, AZ. “Brain Drug Delivery Using Intra-Cerebral Implants.” March 7, 1998. Neurology Grand Rounds, Johns Hopkins School of Medicine, Baltimore, MD. “New Approaches to Brain Tumor Therapy.” March 5, 1998. American College of Surgeons - Young Surgical Investigators’ Conference, Chantilly, VA. “Grant Writing Skills-Mock Study Section on Neurosurgical Surgery.” March 9, 1998. American Association of Neurological Surgeons, Philadelphia, PA. “Current and Novel Treatment of Malignant Gliomas.” April 30, 1998. Visiting Professor, Medical College of Georgia, Augusta, GA. “New Approaches to Brain Tumor Therapy.” May 7, 1998. Angiogenesis Invasiveness Symposium, University of South Florida College of Medicine, Tampa, FL. “Update on Gliadel and Polymer-Based Drug Delivery: Outlook for Polymers as a Vehicle for Local Delivery of Angiostatic Inhibitors of Brain tumors.” May 16, 1998. Neurosurgery Visiting Professor, Beth Israel-Deaconess Hospital, Boston, MA. “New Approaches in Brain Tumor Therapy.” June 24, 1998. Genetics in Neuroscience, 1st International Congress, Terni, Italy. “Management of Gliomas.” June 30, 1998. Korean Brain Tumor Study Group, Seoul, Korea. (1) “Direct Delivery of Therapeutic Agents to Brain Tumors: Clinical and Laboratory Studies,” (2) “Antiangiogenic Approaches to Brain Tumor Therapy.” July 4, 1998. Third Congress of the European Association for Neuro-Oncology (EANO III), Versailles, France. “Interstitial Chemotherapy: clinical Experience and Perspectives.” September 14, 1998. Congress of Neurological Surgeons, Seattle, WA. “From Laboratory Bench to Clinical Application.” Oct 5, 1998. 5th IUBMB Conference on the Biochemistry of Health and Diseases, Jerusalem, Israel. “Implantable SlowRelease Polymers for the Treatment of Brain Tumors.” October 21, 1998. Radiology Grand Rounds, Johns Hopkins School of Medicine. “The Development of New Approaches to Treating Brain Tumors” Oct 27, 1998 United Kingdom and Ireland Controlled Release Society Symposium, Aston University, Birmingham, England. “Polymers for CNS Delivery.” January 8, 1999. Tri-National Meeting of the Israeli, German, and Finnish Neurosurgical Societies, Eilat, Israel. “Current and Future Applications of Polymer Technology for Brain Tumor Therapy.” January 22, 1999. Johns Hopkins Medicine Technology Fair, Baltimore, MD. “New Delivery Approaches for Cancer and for the Brain.” March 19, 1999. American Society for Experimental Neuro-Therapeutics, Inc., Washington, DC. “New Technologies for

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195. 196. 197. 198. 199. 200. 201. 202. 203. 204. 205. 206. 207. 208. 209. 210. 211. 212. 213. 214. 215. 216. 217. 218. 219. 220. 221. 222. 223.

Effective Delivery of Neurotherapeutic Agents.”March 20, 1999 The American Association of Neurological Surgeons, New Orleans, LA. “Craniotomy for Tumor: Outcomes in High Volume Versus Low Volume Hospitals.” April 26, 1999. Johns Hopkins Medical Institutions, Surgical Grand Rounds, Baltimore, MD. “New Approaches for Brain Tumor Therapy.” May 8, 1999. Johns Hopkins Medicine Faculty Leadership Development Program, Baltimore, MD. “Fulfilling the Research Mission: Leadership Challenges (Clinical Research). June 3, 1999. Controlled Release Society, Boston, MA. “Polymer Delivery of Therapeutic Agents for Cancer.” June 24, 1999. Macromolecular Drug Delivery Conference, Breckenridge, CO. “Polymeric Delivery of Cytokines for the Treatment of Tumors.” July 16, 1999. Harvard Medical School Postgraduate Course, Tumors of the Central Nervous System: Brain Tumor Management, Boston, MA. “Interstitial Chemotherapy for Brain Tumors.” September 13, 1999. Fifth Anticancer Drug Discovery and Development Symposium, Detroit, MI. “Polymeric Local Delivery of Therapeutic Agents to Treat Brain Tumors.” September 24, 1999. Visiting Professor, Walter Reed Army Medical Center, Washington, DC. “Advances in Local Therapy for Brain Tumors.” “Development of a Research Program.” Oct 25, 1999. Congress of Neurological Surgeons, Boston, MA. Moderator, Luncheon Seminar, “Current Management of Malignant Gliomas.” November 2, 1999. Visiting Professor, St. Joseph Medical Center, Baltimore, MD. “New Approaches for Brain Tumor Treatment.” December 3, 1999. US-Japan Symposium on Drug Delivery Systems, Kaanapali Beach, Lahaina, HI. “Clinical Development Utilizing Biodegradable Polymer Implants.” December 12-17, 1999. Visiting Professor, University of California, Irvine. “Brain Tumor Treatment-2000.” January 12, 2000. Visiting Professor, Cedars-Sinai Medical Center, Los Angeles, CA. “Brain Tumor Treatment-2000.” January 12, 2000. Visiting Professor, University Hospital of Brooklyn, Health Science Center, Brooklyn, NY. “Adjunct Treatment of Recurrent Glioblastoma Multiforme.” January 27, 2000. American Association of Neurological Surgeons, San Francisco, CA. “New Developments in Local Therapy of Brain Tumors.” April 10, 2000. AANS/CNS Section on Tumors Satellite Symposium, San Francisco, CA. “Implantable Biodegradable Polymers.” April 13, 2000. The Society of Neurological Surgeons, Pasadena, CA. “Brain Tumor Therapy,” May 21, 2000. (Grass Foundation Award) La Genetica Nelle Neuroscienze, Terni, Italy. “Neuro-Oncology Clinical Lecture.” July 3, 2000. Visiting Professor, Yale University, New Haven, CT. “New Approaches to Brain Tumor Therapy.” Sept 6, 2000. Controlled Release Society, International Symposium on Tumor Targeted Delivery Systems, Bethesda, MD. “Polymer Drug Delivery for Cancer Therapy: Clinical Observations.” September 25, 2000. Congress of Neurological Surgeons, San Antonio, TX. Moderator, Luncheon Seminar, “Novel Therapies for Malignant Gliomas.” September 26, 2000. Society for Neuro-Oncology, Annual Meeting, Chicago, IL. Moderator, Session: “Therapeutic Studies 1" November 10, 2000. Pivotal Glioma Trial Meeting, San Juan, Puerto Rico. “Gliadel Clinical Presentation.” November 18, 2000. South Florida Brain Tumor Association, Fort Lauderdale, FL. Keynote Address: “Advances in Brain Tumor Therapy.” Jan 20, 2001. MD Anderson Cancer Center, Houston, Texas, Neurosurgical Oncology Symposium: The Decade Ahead. “Intracavitary Drug Delivery: Clinical Potential.” Jan 27, 2001 Clinical Neuroscience Lecture, Johns Hopkins School of Medicine, Baltimore, MD. “Developments in Brain Tumor Therapy.” Feb 5, 2001. The Cleveland Clinic Foundation, Neuro-Onc Symposium, Naples, FL. “Intratumoral Chemotherapy,” February 19, 2001 “The Structure and Function of NABTT Consortium” Feb 20, 2001. Baltimore Women’s Forum, Baltimore, MD. “The Brain and Intelligence in the New Century.” March 7, 2001.

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224. Visiting Professor, University of Pittsburgh. Pittsburgh, PA. “New Approaches to Brain Tumor Therapy” and “Novel Brain Tumor Therapies.” March 21, 2001. 225. American Association of Neurological Surgeons, Toronto, Canada. Discussant at Scientific Session for abstract “Phase I Clinical Trial of Adenovirus-mediated p53 Gene Therapy for Recurrent Glioma: Biological and Clinical Results,” presenter: Dr. Frederick F. Lang. April 25, 2001. 226. Visiting Professor, Department of Neurosurgery, George Washington University, Washington DC. “NeuroOncology Advances.” May 23, 2001. 227. Johns Hopkins Medical and Surgical Association Biennial Meeting, Johns Hopkins, Baltimore, MD. “New Developments in tumor Therapy.” June 8, 2001. 228. Update in Clinical Neurosciences, Baltimore, MD. Moderator: “Discussion of Case Studies”. June 22, 2001. 229. Accelerate Brain Cancer Cure Retreat (ABC), Santa Barbara, CA. Moderator: “Latest on Brain Cancer” July 13, 2001. 230. The Johns Hopkins University School of Medicine, Neurology Medical Student Clerkship Lecture, Baltimore, MD. “Brain Tumors and Subarachnoid Hemorrhage.” July 17, 2001. 231. Polymers for Advanced Technologies Symposium, Eilat, Israel. “Brain Tumors Treatments with Polymer Delivery Systems: Preclinical and Clinical Results.” Sept 5, 2001. 232. Johns Hopkins University and Technion-Israel Institute of Technology, Baltimore, MD. “Brain Tumor Research.” September 11, 2001. 233. The Congress of Neurological Surgeons, San Diego, CA. Moderator - Luncheon Seminar, “Novel Therapies for Malignant Brain Tumors.” October 2, 2001. Speaker - “Therapeutic Discoveries.” October 3, 2001. 234. Johns Hopkins University School of Medicine, Dean’s Lectures, Baltimore, MD. “Advances in Brain Tumor Therapy.” Dec 3, 2001. 235. FDA Oncology Drugs Advisory Committee (ODAC), Bethesda, MD. "Gliadel Clinical Trials." Dec 6, 2001 236. The 6th US-Japan Symposium on Drug Delivery Systems, Maui, HI. “Biodegradable Polymer Implants to Treat Brain Tumors.” Dec 21, 2001. 237. Visiting Professor, Barrow Neurological Institute, Phoenix, AZ. "Progress in Brain Tumor Therapy." Jan 11, 2002. 238. Johns Hopkins Town Meeting, Baltimore, MD. "Advances in Neurosurgery." Feb 7, 2002. 239. Medical Student Forum, Baltimore, MD. "Women in Surgery." Mar 5, 2002. 240. GMP Scientific Retreat, Hallandale Beach, FL. "Neuroscience: Advances in Drug Delivery to the Brain." April 28, 2002. 241. Johns Hopkins, Baltimore, MD. "Jeffery Williams Memorial." May 30, 2002. 242. Visiting Professor, Dartmouth University Medical Center, New Hampshire. "New Approaches to Brain Tumor Therapy." July 26, 2002. 243. Congress of Neurological Surgeons, Philadelphia, PA. Moderator, Luncheon Seminar "Controversies in Brain Tumor Management." Sept 24, 2002. 244. Premiere "Red Dragon", Senator Theater, Baltimore, MD "Dedication for Brain Tumor Research." Oct 7, 2002. 245. The University of Minnesota Brain Tumor Symposium, Doubletree Hotel, Bloomington, MN. "Advances in Brain Tumor Therapy." October 25, 2002. 246. Mt. Sinai School of Medicine-4th Annual Advances in Neurosurgery, Roosevelt Hotel, New York, NY. "Molecular and Chemotherapeutic Advances." Dec 8, 2002. 247. Johns Hopkins Palm Beach Meeting, Palm Beach, FL. "Neurosurgery." Jan 22, 2003. 248. Guilford Advisory Board, Carlyle Hotel, New York, NY. Moderator of the Brain Tumor Advisory Board. Feb 8, 2003. 249. Thirty Years of Angiogenesis Research: A Symposium in Honor of Dr. Judah Folkman. Children's Hospital, Boston, MA "New Approaches to Brain Tumor Therapy." Feb. 28, 2003. 250. GMP 4th Annual Scientific Retreat, Ft. Lauderdale, FL. "Neurosurgery Update." Mar 9, 2003. 251. American College of Surgeons Oncology Group, Durham, NC. "New Brain Tumor Trials." Mar 27, 2003. 252. Johns Hopkins Biennial Meeting, Baltimore, MD. "New Directions in Neurosurgery." May 2, 2003. 253. Visiting Professor, Dept of Neurosurgery, Emory University, Atlanta, GA. "Treatment of Brain Tumors." Nov 6, 2003. 254. Keynote Speaker, RUNN Conference, Woods Hole, MA. "Research Advances in Neurooncology." Nov 13, 2003. 255. The 7th US-Japan Symposium on Drug Delivery Systems, Maui, HI. “New Approaches to Brain Tumor Updated 10/26/2015

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256. 257. 258. 259. 260. 261. 262. 263.

264. 265. 266. 267. 268. 269. 270. 271. 272. 273.

274. 275. 276. 277. 278.

279.

280.

Therapy.” Dec 14-19, 2003. Lecture, Palm Beach Neurosurgical Meeting, Palm Beach, FL. "Academic Neurosurgery." Jan 24, 2004. Lecture, Fifteenth Annual Cancer Progress Conference, New York, NY. "Novel Formulation Technologies for Cancer Therapy." March 9, 2004. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Translational Research Conference. Baltimore, MD “Targeted Therapy for Brain Tumors.” March 10, 2004. American Association of Neurological Surgeons, Orlando, FL. "Targeted Therapy for Brain Tumors." May 5, 2004. Lecture, AANS Tumor Section Symposium, Orlando, FL. Session: “Controversies in Neurosurgical Oncology.” May 6, 2004. The American Association of Pharmaceutical Scientists, National Biotechnology Conference, Boston, MA. “Biodegradable Polymers as Methods to Enhance Drug Delivery to Tumors of the CNS.” May 18, 2004. Symposium Moderator, Genetics and Regeneration in Neuroscience, 4th International Congress, Terni, Italy. "Advances in Radiation Therapy in the CNS. June 30, 2004. Lecture, The Second Technion-Johns Hopkins Symposium in Medical Sciences and Biomedical Engineering, Technion University, Haifa, Israel. “Developing New Therapies for Brain Tumors: From Laboratory to Bedside. Oct 17, 2004. Johns Hopkins University & Hospital, Evolution of Treatment Options for Adult Patients with Brain Tumors, Baltimore, MD. "Neurosurgical Management of Pituitary Tumors." Oct. 29, 2004. Medical Grand Rounds Speaker, Johns Hopkins University, Baltimore, MD. "New Therapies for Brain Tumors." Dec 17, 2004. Mount Sinai Lecture, New York, NY. "Adjuvant Treatments for Gliomas." Dec. 18, 2004. Technion Lecture, Haifa, Israel. "New Approaches to Brain Tumor Therapy." Dec. 27, 2004 Weizmann Neurobiology seminar, The Weizmann's Institute, Rehovot, Israel. "Therapeutic Delivery to the Brain: Challenges and Opportunities." January 3, 2005 Johns Hopkins Brain Tumor Research Seminar Series, Baltimore, MD. "Therapeutic Delivery to the Brain: Challenges and Opportunities." January 10, 2005 Visiting Professor, Neurosurgery Grand Rounds, Stanford, CA. "New Approaches to Brain Tumor Therapy." February 11, 2005 Keynote Speaker, Society for Biomaterials, Memphis, TN. "Technology Innovation and Development of Gliadel™ for the Treatment of Brain Tumors." April 30, 2005. Hopkins Biotech Network, Baltimore, MD. "Finding Harmony Between Academic Research and Entrepreneurship" Panelist on Gliadel® . May 5, 2005. The Noun Shavit Memorial Lecturer, Ben-Gurion University, Beer Sheva, Israel. The 8th Coleman Fellow in Life Sciences presented to Prof Henry Brem, "Brain Tumor Therapy: Advances from Laboratory Research." May 23, 2005 Dept of Chemical Engineering: "Penetrating the Brain for Therapeutic Delivery." May 24, 2005. Dept of Life Sciences: "Brain Tumor Angiogenesis." May 25, 2005 Johns Hopkins Medical and Surgical Association Biennial Meeting, Baltimore, MD. "New Directions in Neurosurgery at Johns Hopkins." June 3, 2005. E. Llewelyn Thomas lecturer, The Institute of Biomaterials and Biomedical Engineering, Toronto, CA "Brain Tumor Therapy" June 7, 2005 Updates in Neuro-Oncology, Arezzo, Italy. "Translating Research Findings into Clinical Applications." June 25, 2005 Food and Drug Administration, Rockville, MD. "Development of New Therapy for Brain Tumors." September 26, 2005 Congress of Neurological Surgeons Meeting, Boston, MA. Roundtable: Neurosurgeons as Clinical Investigators—An Open Forum on the Future of Brain Tumor Research. Discussion: "Clinical Investigators, Industry Based Trials and Conflicts of Interest, Education and Reward Paradigms, Mechanisms by which AANC/CNS Can Promote Clinical Research and Funding for Clinical Research." October 11, 2005. ATNS (Advanced Technologies in the Neurosciences), American Academy of Arts and Sciences, Cambridge, MA. "Timetables for Scientific Advances into Practice: Brain Tumor Therapy Case Studies." October 19, 2005. RUNN Conference, Woods Hole, MA. "Brain Tumor Therapy." October 27, 2005.

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281. Johns Hopkins Biotechnology Meeting on Neurosurgery, Chicago, IL. "Advances in Neurosurgery Technology". April 10, 2006. 282. Rambam Medical School, Haifa, Israel. " Advances in Brain Tumor Therapy." April 20, 2006. 283. Asilomar 006 Brain Tumor Research and Therapy Meeting at Silverado, CA "Targeting Brain Tumor Therapy." April 27, 2006. 284. Lecture: Johns Hopkins General Surgery Interns. Johns Hopkins Hospital, Baltimore, MD. "Neurosurgical problems and emergencies." May 4, 2006. 285. Second Joint American-Israeli Conference on Cancer, Jerusalem, ISRAEL "New Approaches to Brain Tumor Therapy." June 30, 2006 286. Symposium Honoring Robert S. Langer – 30 Years in Science. Boston, MA "Dr. Langer's Impact on Medicine." July 14, 2006. 287. Neuro-Oncology Update, FedEx Institute of Technology, Memphis, TN "Development of New Therapies for Brain Tumors." August 24, 2006. 288. Congress of Neurological Surgeons, Chicago, IL. Seminar M07 Moderator "Malignant Gliomas: Current Surgical and Adjuvant Strategies." Oct. 9, 2006. 289. American Academy of Neurological Surgery, Ritz Carlton Reynolds Plantation, GA. "Directed Therapy with Polymers for Brain Tumors." October 21, 2006. 290. RUNN Conference, Woods Hole, MA. "Brain Tumor Therapy." October 22, 2006. 291. The Johns Hopkins Health System Corporation and The Johns Hopkins Hospital Board. Baltimore, MD "Neurosciences Safety Initiatives." December 5, 2006. 292. David H. Koch Building Dedication, Johns Hopkins School of Medicine, Baltimore, MD. "From Discovery to Results." December 5, 2006. 293. Visiting Professor, Grand Rounds, University of Medicine and Dentistry of New Jersey, Newark, NJ. "Brain Tumor Therapy: From Bench to Bedside." December 13, 2006. 294. Florida Brain Tumor Association, 8th biennial Brain Tumor Conference, Fort Lauderdale, FL. "Developing New Brain Tumor Therapies." January 20, 2007. 295. Discussant for Scientific Session, American Association of Neurological Surgeons, Washington, DC. Young Investigator Award Presentation: "Autologous Heat Shock Protein Vaccine for Recurrent Glioma: Results of a Phase I Clinical Trial," T. Parsa, et al. April 16, 2007. 296. The Johns Hopkins Medical and Surgical Association, 2007 Biennial Meeting and Reunion, Baltimore, MD. Opening Remarks "New Directions in NUS at Johns Hopkins." June 1, 2007. 297. 2007 Rosomoff Visiting Professor, Department of Neurosurgery, University of Miami, Miami, Florida. "New Approaches to Brain Tumor Therapy." and "Brain Tumor Angiogenesis." June 2, 2007. 298. 56th Congresso Nazionale SINch, Rome, Italy "New Therapies for Malignant Gliomas." June 26, 2007. 299. 3rd International Meeting Updates in Neuro-Oncology, Cortona, Arezzo, Italy "Developing New Therapies for Brain Tumors." June 30, 2007. 300. Presentation, Vision 2020-The 2006 Report of the University Committee on the Status of Women at the Johns Hopkins University, Baltimore, MD. “Progress in Neurosurgery.” September 10, 2007. 301. The Congress of Neurological Surgeons, San Diego, CA. Seminar Moderator : "Malignant Gliomas: Future Treatment Alternatives." September 17, 2007. Luncheon Seminar: "How to Pursue an Academic Career in Neurosurgery." September 18, 2007. Section on Tumors II – Senior Discussant: "Gene Therapy." September 19, 2007. 302. 2007 International Workshop on Glioma Research and Therapy; Brigham and Women's Hospital, Harvard Medical School; Boston, MA. "Surgical Therapies for Glioma." Oct 10-13, 2007 303. Lecture, RUNN Course, Woods Hole, MA. "Brain Tumor Therapy.” October 21, 2007. 304. Moderator and Scientific Program Chair. The American Academy of Neurological Surgery, Lake Las Vegas, NV. October 31 – November 3, 2007. 305. Plenary Lecture, 9th US-Japan Symposium on Drug Delivery Systems, Maui, HI. "Targeted Brain Tumor Therapy." December 17, 2007. 306. Guest Lecturer, The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada. "Targeting Brain Tumor Therapy.” January 24, 2008. 307. Neurosurgery Resident Lecture, The Hospital for Sick Children, Toronto, CA. “Brain Tumor Angiogenesis.” January 25, 2008. 308. Visiting Professor, Neurosurgery Grand Rounds, Cornell University, Ithaca, NY “Developing New Therapies for Brain Tumors.” Feb. 11, 2008. Updated 10/26/2015

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309. Visiting Professor, Neurosurgery Grand Rounds, Montefiore Hospital, NY. "Brain Tumor Therapy.” March 24, 2008. 310. American Association of Neurological Surgeons, Chicago, IL. Breakfast seminar - Tumor Neurosurgery: Meet the Experts. “Targeting Brain Tumor Therapy.” May 1, 2008. 311. Guest Lecturer, The Johns Hopkins University Department of Neurosurgery Symposium on Multidisciplinary Perspectives in Brain Tumor Management, Puerto Vallarta, Mexico. “Brain Tumors: The Hopkins Experience.” August 14, 2008. 312. Guest Lecturer, 7th Annual International Neuro-Oncology Updates, Baltimore, MD. “Brain Tumors: Targeted Therapy.” September 18, 2008. 313. Congress of Neurological Surgeons Meeting, Orlando, FL. “Preparing for an Academic Laboratory Career: Residency and the Early Faculty Years.” Sept 22, 2008. 314. Congress of Neurological Surgeons Meeting, Orlando, FL. “How to Pursue an Academic Career in Neurosurgery.” Sept 23, 2008. 315. RUNN Course, Woods Hole, MA. "Advances in Brain Tumor Therapy." October 19, 2008. 316. Visiting Professor, Cedars-Sinai Medical Center, Los Angeles, CA. Dinner Lecture "Advances in Brain Tumor Therapy," Nov 13, 2008. 317. The Johns Hopkins Neurosurgery Grand Rounds "Developing New Treatments for Brain Tumors," Nov 14, 2008. 318. Speaker, Neuro Critical Care Unit Research Seminar, Johns Hopkins University, Baltimore, MD “Advances in Brain Tumor Therapy,” November 18, 2008 319. Guest Lecturer, Folkman Symposium, Harvard Medical School, Boston, MA. “Dr. Folkman’s Impact on Neurosurgery” Dec 5, 2008. 320. George Washington University School of Medicine, Washington, DC. “Targeted Brain Tumor Therapy.” January 15, 2009. 321. Keynote Speaker, 44th Annual Pharmaceutical Technologies Arden Conference (AAPS) Arden House, West Point, NY. "How Drug Delivery and Targeting will Impact the Future of Medicine.” February 2, 2009. 322. Invited Lecturer: "Brain Tumor Therapy: Gliadel as a Case Study." February 2, 2009. 323. The Johns Hopkins Neuroscience Nurse Clinician II Workshop, Baltimore, MD. “Brain Tumor Therapy: The Evolution of Gliadel.” February 23, 2009. 324. Visiting Professor, 35th Annual symposium, Barrow Neurological Institute, Phoenix, AZ. “Advances in Brain Tumor Therapy.” March 5, 2009. 325. Visiting Professor, 35th Annual symposium, Barrow Neurological Institute, Phoenix, AZ. March 6, 2009. 326. Guest Lecturer, The Baltimore City Medical Society, Baltimore, MD. “Advances in Brain Tumor Therapy.” March 10, 2009. 327. Johns Hopkins Medical Institution, School of Medicine Neuroscience Lecture, Baltimore, MD “Classification of Brain Tumors.” March 26, 2009. 328. Visiting Professor, Grand Rounds, Henry Ford Hospital, Detroit, MI. “Developing New Targeted Treatments for Brain Tumors.” April 1, 2009. 329. 2009 American Association for Cancer Research, Denver, CO. Co-Chair, New Concepts Session: Invading the Sanctuary: New Approaches to Brain Metastases. “Introduction: Importance of Brain Metastasis” April 19, 2009. 330. The Musella Foundation: Central NJ. Brain Tumor Support Group: You are not Alone!! “Advances in Brain Tumor Therapy.” May 9, 2009. 331. Henry A. Shenkin, MD Lecture, Temple University, Philadelphis, PA. “Developing New Targeted Treatments for Brain Tumors.” June 12, 2009. 332. Johns Hopkins Neurosurgical Oncology Grand Rounds, Johns Hopkins University, Baltimore MD. “Developing New Targeted Treatments for Brain Tumors.” July 24, 2009 333. EISAI, Co., LCD, Baltimore, MD. “Brain Tumor Therapy: Gliadel as a Case Study.” August 21, 2009 334. 1st. Annual Johns Hopkins Pituitary Tumor Center, Patient Education Day, Mount Washington, MD. “Surgical Therapy of Pituitary Tumors.” September 26, 2009. 335. NCCN2 Annual Forum: Innovative Diagnostics and Therapeutics in Cancer Care. New York, NY. “Use of BCNU Wafers in Aggressive Gliomas.” October 2, 2009. 336. RUNN COURSE, Woods Hole, MA. “Advances in Brain Tumor Therapy.” October 17-24, 2009. 337. American Academy of Neurological Surgery, Palm Beach, FL. “High Grade Glioma & Data Supporting Maximal Resection.” Nov 4-7, 2009 Updated 10/26/2015

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338. University of North Carolina Lineberger Comprehensive Cancer Center Clinical Symposium, Chapel Hill, NC. “Translating Scientific Advances into Clinical Care for Brain Tumors.” November 7, 2009. 339. 10th Biannual US-Japan symposium on drug Delivery Systems, Maui, HI. “Advances in Brain Tumor Therapy.” December 17, 2009. 340. EISAI Meeting, Chicago, IL “Brain Tumor Therapy: Gliadel as a Case Study”. January 26, 2010 341. Johns Hopkins University School of Medicine Surgery Grand Rounds, Baltimore, MD. “Translating Scientific Advances Into Clincal Care for Brain Tumors ”, April 1, 2010 342. Johns Hopkins Neuroscience Nursing, Baltimore, MD. “Translating Scientific Advances Into Clincal Care for Brain Tumor Patients.” April, 26, 2010. 343. 14th BiAnnual Canadian Neuro-Oncology Meeting, Niagara-on-the-Lake, Ontario, Canada. “Developing New Brain Tumor Approaches.” May 15, 2010. 344. Traumatic Brain Injury in Professional Football: An Evidence-Based Perspective. Washington, DC. “Setting the Tone.” June 2, 2010 345. 15th Van Wagenen Professor and Lecturer, Rochester, NY Grand Rounds Lecture “New Approaches to Brain Tumor Therapy”. June 18, 2010. 346. 15th Van Wagenen Professor and Lecturer, Rochester, NY Grand Rounds Lecture “Neurosurgery at Johns Hopkins”. June 18, 2010. 347. 9th International Meeting: Updates in Neuro-Oncology, Cortona, Italy “Developing New Therapies for Malignant Gliomas”. July 3, 2010 348. 11th Hugo V Rizzoli Distinguished Surgical Lecture in Neurosurgery, Johns Hopkins University, Baltimore, MD. “Brain Tumor Surgery”. November 15, 2010 349. Washington Academy of Neurosurgery, George Washington University, Washington, DC. “Improving Access to Neurosurgical Care”. November 15, 2010 350. 4th Annual Johns Hopkins Skull Base Course. Baltimore, MD. “Craniofacial Approaches to the Skull Base: From Open to Endoscopic”. December 3, 2010 351. New Clinical Building Partnering Session, Johns Hopkins, Baltimore, MD “Brain Tumor Surgery”. December 9, 2010 352. Howard Hughes Medical Student Symposium, Johns Hopkins, Baltimore, MD December 13, 2010 353. Keynote Speaker, Johns Hopkins Medical Student Research Day, Baltimore, MD. January 5, 2011 354. Nanomedicine Conference at Cedars-Sinai Medical Center in Los Angeles, CA “Brain Microchips to Treat Brain Tumors”. March 4, 2011 355. Johns HopkinsMedicine- Brain Science Institute Brain Night. Baltimore MD “Challenges of Treating Tumors in the Brain” March 9, 2011 356. JHMI International Neurosurgery, Baltimore, MD. “Johns Hopkins Neurosurgery Innovations”, March 23, 2011 357. Genes to Society, Johns Hopkins University School of Medicine, Baltimore, MD. “Neuroscience Clinical Correlations”. May 4, 2011 358. Johns Hopkins Neuroscience Nursing, Baltimore, MD. “Translating Scientific Advances Into Clincal Care for Brain Tumor Patients.” May 16, 2011 359. Commencement Address , Johns Hopkins University School of Medicine, Graduation, Baltimore, MD May 24, 2011 360. Johns Hopkins Medicine-A Womans Journey Executive Breakfast, Washington, DC “Heads Up: The Ability of the Brain to Recover” May 18, 2011 361. Plenary Lecture, Controlled Release Society 38th Annual Meeting and Exhibition, National Harbor, MD “Challenges of Therapeutic Delivery to the Brain”. August 3, 2011 362. Controlled Release Society 38th Annual Meeting and Exhibition, National Harbor, MD. “Healthcare of the Future: How Pharmaceutical Advances Are Changing Medical Practice”. August 3, 2011 363. Fourth Annual Quinones-Hinojosa Stem Cell Luncheon for Patients, Mt. Washington Conference Center, Baltimore, MD. “Educating Patients on Research Therapies for Brain Tumors”. August 6, 2011. 364. Session Moderator, 10th Annual International Neuro-Oncology Updates. “Brain Tumor Clinical Management”. Nashville, TN, September 15, 2011 365. Research Update in Neuroscience for Neurosurgeons (RUNN), Marine Biological Laboratory Woods Hole, Massachuesetts. “Advancing Brain Tumor Therapy”. October 30 – November 6, 2011. 366. Plenary Lecture, Association of American Medical Colleges Annual Meeting, Denver, CO. “Changing Times, Changing Partnerships: Propelling Research by Rethinking Collaborations,” Nov. 6, 2011 Updated 10/26/2015

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367. Johns Hopkins Medicine-A Womans Journey Seminar Series, Baltimore, MD “Repairing the Brain”. November 12, 2011. 368. Concurrent Meetings of the Boards of Trustees of THE JOHNS HOPKINS HEALTH SYSTEM CORPORATION and THE JOHNS HOPKINS HOSPITAL, Baltimore MD. “Innovations in Neurosurgery Safety”. December 5, 2011 369. Visiting Professorship, Stuart Rowe Lectureship, University of Pittsburgh, Pittsburgh, PA. “Advancing Brain Tumor Therapy” December 7, 2011. 370. Visiting Professorship, Stuart Rowe Lectureship, University of Pittsburgh, Pittsburgh, PA. “Improving Access to Neurosurgical Care” December 7, 2011. 371. Plenary Lecture, 11th US-Japan Symposium on Drug Delivery Systems, Maui, Hawaii. “Delivery of Therapeutic Agents to the Brain” December 19, 2011. 372. Deans Research Integrity Lecture Series, Johns Hopkins University, Baltimore, MD. “Research Integrity, The Scientist as a Responsible Member of Society”. January 23, 2012 373. Top of the World Meet Top of China Symposium, BeiJing, China. “Opening Remarks” at Part 1,. March 6, 2012 374. Top of the World Meet Top of China Symposium. Xi’An, China . “Drug Delivery for Brain Tumors” at Part 2,. March 8, 2012 375. Top of the World Meet Top of China Symposium. “Topic 1”.at Seminar, ShangHai, China. March 10, 2012. 376. Johns Hopkins University, Neurosurgery Grand Rounds, Baltimore, MD. Developing New Brain Tumor Therapies. May 31, 2012. 377. Accelerating US-Israel Neuroscience and Neurotechnology Collaborations. National Academy of Sciences, Washington, DC. “Intraoperative Brain Tumor Therapy”. September 12, 2012. 378. Plenary Lecture, 11th Annual International Neuro-Oncology Updates. Baltimore, MD. “Developing Brain Tumor Therapies”.September 20, 2012. 379. Johns Hopkins Hospital Board of Trustees Quality Improvement Committee. Baltimore, MD. “How can Neurosurgery continue to provide and improve patient care”. October 22, 2012. 380. Vanderbilt University Medical Center, Department of Neurosurgery Grand Rounds, Nashville TN. “Developing New Approaches to Brain Tumor Therapy”. October 26, 2012. 381. The Second Israeli Medical Student’s Conference. The Treatment for Brain Cancer-The Whole Picture. Tel Aviv University, Tel Aviv, Israel. “The Neurosurgical Experience at Johns Hopkins”. December 28, 2012. 382. University of Maryland, Department of Neurology Grand Rounds, Baltimore, MD. “Developing Brain Tumor Therapies”. February 6, 2013. 383. Dean's Research Integrity Lecture Series. Johns Hopkins University, Baltimore, MD. “Research Integrity, the Importance of the Scientist as a Responsible Member of Society”. February 14, 2013. 384. Johns Hopkins University Executive Support Staff Group, Baltimore, MD. “Brain Repair”. March 15, 2013. 385. Israel Neurosurgery Society Annual Meeting, Herzilya, Israel. Session II From Experimental To New Horizons in Clinical Neurosurgery “Technology to Improve Brain Tumor Outcomes”. March 20, 2013. Session VIII New Modalities in Brain Tumor Surgery “Developing New Therapies for Brain Tumor Therapy”. March 22, 2013. 386. Keynote Speaker, Office of Research Integrity at 20, ORI and Johns Hopkins University, Baltimore, MD. “Reassessing Research Integrity”. April 4, 2013 387. 81st AANS Annual Scientific Meeting Discussant on Oral Abstract Presentation , New Orleans, Louisiana. “Development of an MRI-guided Delivery and Molecular Targeting System for Glioblastoma multiforme Theranostics based on Surface Enhanced Raman Scattering Nanoparticles”. April 27 to May 1, 2013. 388. The Michael S. Voynick Lecture in Neuro-Oncology. Yale School of Medicine, New Haven, CT. “Developing Brain Tumor Therapies”. May 8, 2013. 389. Institute of Medicine of the National Academies, Roundtable on Translating Genomic-Based Research for Health, Washington, D.C. "Assuring Integrity While Facilitating Innovation in Medical Research". June 5, 2013. 390. Wake Forest University School of Medicine, 10th Anniversary Brain Tumor Center of Excellence Annual Retreat, Winston-Salem, NC. “Developing Brain Tumor Therapies”. September 20, 2013. 391. Teva Pharmaceutical Industries & Johns Hopkins University, Baltimore, MD. “ Propelling Research by Rethinking Collaborations”. September 30, 2013 392. Johns Hopkins University School of Medicine, Baltimore, MD. Diseases and Disorders of the Nervous System Course. “Developing Brain Tumor Therapies”. October 17, 2013 Updated 10/26/2015

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393. AANS/CNS Section on Tumors and Society of Neuro-Oncology Abhijit Guha Award and Plenary Lecture, San Francisco, CA. “Developing Brain Tumor Therapies”. October 22, 2013. 394. Research Update in Neuroscience for Neurosurgeons (RUNN), Marine Biological Laboratory Woods Hole, Massachuesetts. “Advancing Brain Tumor Therapy”. October 29, 2013. 395. Weitzman Institute, Rehovot, Israel. “Understanding and Exploiting the Genetic Basis of Brain Tumors”. October, 2013 396. Plenary Lecture, EANS Tumor Section-AANS/CNS Section on Tumors-Annual International NeuroOncology Updates. Tel Aviv, Israel. “ How to Build a Neuro-Oncolology Program”. November 13, 2013. 397. Keynote speaker, A Cushing Neuroscience Institute Symposium, Hofstra North Shore LIJ School of Medicine, The Feinstein Institute for Medical Research, New York Neurosurgery:, Manhasset, NY. “Intralesional Treatment of Brain Tumors”. December 13, 2013 398. US-Japan Symposium on Drug Delivery Systems. Lahaina, Maui, Hawaii. “Developing Brain Tumor Therapies” December 16, 2013. 399. National Institutes of Health, NINDS Grand Rounds. Bethesda, MD. “Effectively Delivering Therapies to the Brain”. February 11, 2014. 400. CaRTT Translational Research Lecture Series: University of Western Ontario and London Health Sciences Center. London, Ontario, Canada. “Translational Research for Brain and Metatastic Brain Tumor Patients”. February 20, 2014. 401. Montefiore Medical Center Grand Rounds, Albert Einstein College of Medicine, Bronx, NY. “Treating Brain Tumor Patients” February 24, 2014. 402. American Friends of Tel Aviv University TAU on the Potomac. Four Seasons Hotel in Washington, DC. “Making cancer a chronic disease.” March 8, 2014 . 403. Centers for Medicare and Medicaid Services , ICD-10-CM/PCS Coordination and Maintenance Committee Meeting. Baltimore, MD. “Gliadel” March 19, 2014. 404. JHU Fifth Annual Spinal Disorders: Updates in Diagnosis and Management, Johns Hopkins Hospital. April 19, 2014. 405. Johns Hopkins University, Neurosurgery Grand Rounds, Baltimore, MD. “How to Build a Neuro-Oncology Program”. April 24, 2014 406. Brainiacs: Recent Advances in Neuroscience 2014 Science Writers Boot Camp. The National Press Club, Washington D.C. “Breakthrough Treatments: Brain Tumor vaccines and Direct-To-The Brain Chemotherapy.” April 28, 2014. 407. NSS Case Conference Leaders of Brain Science Lunches. Johns Hopkins University School of Medicine, Baltimore MD. May 7, 2014. 408. Recent Advances in Targeted Delivery of Biologics and Small Molecule Drugs. Center for Drug Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, MD. “Developing Brain Tumor Therapies; Effectively Delivering Therapies to the Brain.” May 19, 2014. 409. Johns Hopkins University School of Medicine, Baltimore, MD. “Helping Patients with Brain Tumors”. May 29, 2014 410. Keynote Speaker, Brain Tumor Biotech Summit 2014. The Weill Cornell Brain and Spine Center, Weill Cornell Medical College, NY, NY. “BCNU impregnated Gliadel wafers: lessons learned about Biotech and Brain Tumors”. June 6, 2014. 411. The Institute for Clinical and Translational Research Translational Research Communities, Johns Hopkins University, Baltimore, MD. “Overcoming Barriers: Gliadel Wafers as a Case Study”. July 9, 2014. 412. 13th Annual International Neuro-Oncology Updates, Boston Massachusetts. “How new treatments for Gliomas get accepted: Opportunities VS Obstacles”. September 4, 2014. 413. Keynote Speaker, The 9th Biennial Meeting of the Israeli Chapter of the Controlled Release Society. Nanomedicines in Cancer Treatment. Maalot Tarshiha, Western Galilee, Israel. “Targeted Brain Tumor Therapy”. September 9, 2014. 414. Johns Hopkins University, “Henry Brem Professorship”. Palm Beach FL. October 6, 2014. 415. Johns Hopkins University, Baltimore MD. “Solomon Snyder and George Heuer Professorship”. October 10, 2014 416. Research Update in Neuroscience for Neurosurgeons (RUNN), Woods Hole, MA. “Advances in Brain Tumor Therapy”. October 28, 2014. 417. Research Update in Neuroscience for Neurosurgeons (RUNN), Woods Hole, MA. “How to Pursue an Academic Career in Neurosurgery”. October 28, 2014. Updated 10/26/2015

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418. Diseases and Disorders of the Nervous System, Johns Hopkins University, Baltimore, MD. “Developing Brain Tumor Therapies”. October 30, 2014. 419. Speaker and Moderator, Religious, Medical, Ethical and Legal Perspectives on End of Life Issues. Institute for Jewish Continuity, The University of Maryland Schools of Medicine, Nursing, Pharmacy and Social Work, and The Maryland Healthcare Ethics Committee Network at the UM Carey School of Law. Panel Discussion: “Overview of Case Study in an Adult”. November 14, 2014. 420. Johns Hopkins Hospital Womens Advisory Board, Baltimore, MD. “Neurosurgery at Johns Hopkins”. February 23, 2015. 421. The Inaugural Indo-US Translational Neuroscience Symposium: Biomarker Discovery and Validation. Johns Hopkins University. “Translational Neuroscience: Johns Hopkins Neurosurgery”. February 25, 2015. 422. Visiting Professor, Stanford University Department of Neurosurgery Grand Rounds Lecture, Stanford, CA. “Developing New Treatments for Brain Tumors”. April 24, 2015. 423. AANS/CNS Section on Tumors 11th Biennial Satellite Symposium. Washington, D.C. “Surgical Trials: Gliadel”. May 1-2, 2015. 424. 14th International Updates in Neuro-Oncology Meeting, Presidential Address. Cortona Italy. July 2, 2015. 425. 1st Annual HARVARD-JOHNS HOPKINS Multidisciplinary Symposium, Harvard Club, Boston, MA. “Lessons learned from Dr. Murray”. September 19, 2015. 426. Keynote Lecture, 1st Annual HARVARD-JOHNS HOPKINS Multidisciplinary Symposium, Shriners Hospital, Boston, MA. “Harvard-Hopkins tradition in neurosurgery and craniofacial surgery”. September 20, 2015. 427. 1st Annual HARVARD-JOHNS HOPKINS Multidisciplinary Symposium, Shriners Hospital, Boston, MA. “Syndrome of the trephined”. September 20, 2015. 428. Plenary Speaker, 13th US-Japan Symposium on Drug Delivery Systems. Lahaina, Maui, Hawaii. “Advances in brain Tumor Therapies” December 16-20, 2015.

OTHER PROFESSIONAL ACCOMPLISHMENTS

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Brem S, Finkelstein D, Chen C, Brem H, Folkman J, and Patz A. "Retinal neovascularization: Experimental induction by intravitreal tumor." Investigative Ophthalmology, Supp., 14:21, l975. Brem H and Folkman J. "Inhibition of tumor angiogenesis." In Year Book of Surgery, J.S. Najarian, ed., Year Book Medical Publishers, Chicago, 1977. Brem S, Preis I, Langer R, Brem H, Folkman J, and Patz A. "Vitreous inhibition of tumor angiogenesis." Investigative Ophthalmology, Supp., 16:54, l977. Prendergast R, Lutty G, Thompson D, Liu S, Patz A, and Brem H. "Corneal inflammation and neovascularization induced by a purified protein with lymphokine activity. Investigative Ophthalmology, Supp., 19, l980. Leong KW, Simonte V, Hilton J, Colvin OM, Brundrett B, Brem H, and Langer R. "Bioerodible polyanhydrides for cancer chemotherapy." Proceedings of the Controlled Release Society, 12:106-107, 1985. Won SK, Bronner AJ, Brem H, Carson BS, and Rosenbaum AE. "Improving ultrasound intraoperative localization and operation of large, variegated lesions: The stringed metallic clip." Annual meeting of the American Society of Neuroradiology, San Diego, CA., January 23, 1986. LaFrance ND, Links J, Williams J, Holcomb H, Dannals R, Ravert, H, Wilson A, Drew H, Herda S, Wong D, Brem H, Long D, and Wagner H, Jr. "C11-methionine and F18-deoxyglucose (FDG) in the postoperative management of patients with brain tumors with positron emission tomography." Journal of Nuclear Med., 27:890, 1986. Zinreich JS, Wang H, Epstein JI, Brem H, Anderson JH, Rosenbaum AE. "Carotid bifurcation imaging model for more accurately comparing imaging techniques." XIII Symposium Neuroradiologicum, Stockholm, Sweden, June 23-28, 1986. Steen RG, Tamargo RJ, Rajan S, McGovern R, Brem H, Wehrle JP, and Glickson JD. "In vivo 31P NMR

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detects the response of 9L gliosarcoma to chemotheraphy with BCNU." Symp American College of Radiology, Banff, Canada, April 21, 1987. Tamargo RJ, Epstein JI, and Brem H. "Heterotransplantation of Mouse and rabbit tumors to the quadrigeminal cistern of neonatal rats." American Association of Neurological Surgeons, Dallas, Texas, May 3, 1987, p. 255. Tamargo RJ, Leong K, and Brem H. "Inhibition of growth of the 9L glioma by the local sustained release of angiogenesis inhibitors." Joint Tumor Section Session of the American Assoc of Neurological Surgeons, Dallas, TX, May 3, 1987, p. 132. LaFrance ND, O'Tuama L, Villemagne V, Williams J, Douglass K, Dannals RF, Ravert H, Wilson A, Drew H, Links J, Wong D, Carson B, Brem H, Strauss L, and Wagner HN, Jr. "Quantitative imaging and follow-up experience of C-11-L-methionine accumulation in brain tumors with positron emission tomography." Journal of Nuclear Medicine 28(4):645,1987. Brem H, Fossett D, Myseros JS, Leong KW, Tamargo RJ, Colvin M, and Hilton J. "Sustained local release of a biologically active chemotherapeutic agent by a new bioerodible polymer." Annual Meeting of the Congress of Neurological Surgeons, Baltimore, Maryland, October 24, 1987. Tamargo RJ, Steen RG, Rajan SS, McGovern K, Wehrle JP, Glickson JD, and Brem H. "In vivo 31P NMR spectroscopy of the 9L gliosarcoma following treatment with BCNU." Annual Meeting of the Congress of Meurological Surgeons, Baltimore, Maryland, October 24, 1987. Tamargo RJ, Myseros JS, and Brem H. "Growth inhibition of the 9L gliosarcoma by the local sustained release of BCNU: A comparison of systemic versus regional chemotherapy." American Association of Neurological Surgeons, Toronto, Canada, pp 212-214, April 24, 1988. Tamargo RJ, Epstein JI, Reinhard CS, Chasin M, and Brem H. "Brain biocompatibility of a biodegradable polymer capable of sustained release of macromolecules." American Association of Neurological Surgeons, Toronto, Canada, April 24, 1988, p. 399. Tamargo RJ, Epstein JI, and Brem H. "Heterotransplantation of malignant gliomas to the quadrigeminal cistern and subcutaneous space of neonatal rats." American Association of Neurological Surgeons, Toronto, Canada, April 24, 1988, p. 409. Brem H, Tamargo RJ, Pinn M, and Chasin M. "Biocompatibility of a BCNU-loaded biodegradable polymer: A toxicity study in primates." American Association of Neurological Surgeons, Toronto, Canada, April 24, 1988, p. 381. Brem H, Carson BS, LaFrance ND, O'Tuama L, and Wagner HN. "Positron emission tomography: Quantitative imaging and experience with C-11-L-methionine accumulation in brain tumor patients." American Association of Neurological Surgeons, Toronto, Canada, April 24, 1988, p. 350. Brem H, Ahn H, Tamargo RJ, Pinn ML, and Chasin M. "A biodegradable polymer for intracranial drug delivery: A radiological study in primates." American Association of Neurological Surgeons, Toronto, Canada, April 24, 1988, p. 349. Yang M, Tamargo R, Leong K, and Brem H. "Sustained systemic delivery of BCNU from an intraperitoneal polymer implant." American Association of Neurological Surgeons, Toronto, Ontario, Canada, April 1988, p. 414. Steen G, Tamargo R, McGovern K, Glickson J, and Brem H. "In vivo 31P NMR spectroscopy of the 9L gliosarcoma: Dose-dependent changes in tumor bioenergetics following chemotherapy with BCNU." American Association of Neurological Surgeons, Toronto, Ontario, Canada, April 1988, p. 409. Malat J, Brem H, Kumar A, Wang H, and Carson B. "Intraoperative ultrasound of brain tumors, CT and MRI correlation." American Association of Neurological Surgeons, Toronto, Ontario, Canada, April 1988. Grossman SA, Reinhard CS, Brem H, Brundrett R, Chasin M, Tamargo R, and Colvin OM. "The intracerebral delivery of BCNU with surgically implanted bioerodable polymers: A quantitative autoradiographic study." Proceedings of the American Society of Clinical Oncology, 7:84, 1988. Griffin CA, Long PP, Brem H, Carson BS, Tamargo RJ, and Grossman SA. "Chromosome abnormalities in central nervous system tumors." Proceedings of American Association Cancer Research, 29:28, 1988. O'Tuama L, Douglass K, Phillips P, Strauss L, Links J, Dannals R, Ravert H, Wilson A, Carson B, Brem H, Wong D, LaFrance N, and Wagner H, Jr. "Maturation of cerebral neutral aminoacid accumulation from childhood to the adult: A C-11-L-methionine PET study." Society of Nuclear Medicine 35th Annual Meeting, San Francisco, CA., Journal of Nuclear Medicine, 29(5):784, 1988. Yang MB, Tamargo TJ, and Brem H. "Intracranial versus systemic delivery of BCNU using an implantable controlled release polymer." Annual Meeting of the Congress of Neurological Surgeons, Seattle,

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Washington, Sept. 24, 1988. Griffin CA, Long PP, Brem H, Carson BS, and Grossman SA. "Cytogenetics of central nervous system tumors: Specific abnormalities and comparison of culture methods." 3rd International Workshop on Chromosomes in Solid Tumors, Feb. 26-28, 1989. Tamargo RJ, Sills AK, Reinhard C, and Brem H. "Controlled release of dexamethasone from a polymer implant in the brain." American Association of Neurological Surgeons, Washington, D.C., April 3, 1989, p. 383. Tamargo RJ, Epstein JI, Yang MB, Pinn ML, Chasin M, and Brem H. "Interstitial vs systemic chemotherapy of the intracranial 9L gliosarcoma: Controlled-release polymers for local therapy." Proceedings of AANS, Vol.30:88, 1989. Olivi A, Duncan KLK, Corden BJ, Lenartz D, Pinn ML, Frye RM, and Brem H. "Comparison of the CNS toxicity of cisplatin, iproplatin and carboplatin given by intrathecal administration in a rat model." Proceedings of the American Association for Cancer Research, 30:466, 1989. Brem H. "Delivery of drugs to the brain by a controlled-release polymer system." Proceed. Internat'l. Symp. Control. Rel. Bioact. Mater., 16:7-8, 1989. Olivi A, Pinn ML, Ewend MG, Chan DW, and Brem H. "Use of polymers to locally release carboplatin and inhibit the growth of Walker 256 carcinosarcoma." Ped. Section of Amer Assoc of Neurol Surgeons, Washington, DC, Nov 28 - Dec 1, 1989. Nabors MW, Griffin CA, Zehnbauer BA, Kaufman SH, Grossman SA, Zhao XL, Brem H, Long DM, Chu YW, Phillips PC, and Colvin OM. "MDR1 expression in human brain tumors. Proceedings of the Amer Association for Cancer Research, 31:355, 1990. Griffin CA, Long PP, Carson BS, Brem H, and Grossman SA. "Cytogenetics of central nervous system tumors: Comparison of culture methods and specific abnormalities." Proceedings of the Amer Association for Cancer Research, 31:25, 1990. Phillips PC, Black AD, Carson BC, Brem H, Morelos J, and Colvin OM. "Glutathione-s-transferase (GST) activity and glutathione (GSH) concentration in human brain tumor biopsies." Proceedings of the Amer Assoc for Cancer Research, 31:355, 1990. Brem H. "Controlled-release polymer systems for drug delivery to the brain." American Chemical Society, 199:117, 1990. Olivi A, Lenartz D, Domb A, Dureza C, Pinn ML, and Brem H. "Treatment of F98 rat glioma with local controlled-release of carboplatin from a biodegradable polymer." International Symmposium on Advances in Neuro-Oncology, Sanremo, Italy, September 1990. Brem R and Brem H. "Biodegradable polymer for intracranial drug delivery: A radiologic study in monkeys and humans." Advances in Neuro-Oncology, Sanremo, Italy, September 1990. Brem H, Mahaley MST, Vick NA, Black K, Schold SC, Burger PC, Friedman AH, Circic IS, Eller TW, Cozzens JW, and Kenealy JN. "Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas." Advances in Neuro-Oncology, Sanremo, Italy, September 1990. Reinhard CS, Radomsky ML, Saltzman WM, Hilton J, and Brem H. "Polymeric controlled release of dexamethasone in normal rat brain." Advances in Neuro-Oncology, Sanremo, Italy, September 1990. Brem H, Mahaley MST, Vick NA, Black K, Schold SC, Burger PC, Friedman AH, Circic IS, Eller TW, Cozzens JW, and Kenealy JN. "Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas." Congress of Neurological Surgeons, Los Angeles, CA, 1990. Guerin C, Laterra J, Hruban R, Brem H, Drewes L, and Goldstein G. "The glucose transporter and bloodbrain barrier of human brain tumors." Congress of Neurological Surgeons, Los Angeles, CA, 1990. Long PP, Carson BS, Brem H, Grossman S, and Griffin CA. "Chromosome abnormalities in low grade central nervous system (CNS) tumors." 4th International Workshop on Chromosomes in Solid Tumors, Tucson, Arizona, Cancer Genetics and Cytogenetics, February, 1991. Griffin CA, Long PP, Brem H, Carson BS, and Grossman SA. "Chromosome analysis of 50 high grade astrocytomas." 4th International Workshop on Chromosomes in Solid Tumors, Tucson, Arizona, Cancer Genetics and Cytogenetics, February, 1991. Brem H, Mahaley S, Vick NS, Black K, Schold SC, Burger PC, H. Friedman AF, Ciric IS, Eller TW, and Cozzens JW. "Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas." American Association of Neurological Surgeons, New Orleans, LA, April, 1991, p. 527. Tamargo RJ, Olivi, A, Bok, RJ, and Brem H. "Angiogenesis inhibition by Minocycline." American Association of Neurological Surgeons, New Orleans, LA, April, 1991, p. 525.

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Olivi A, Domb A, Lenartz D, Dureza C, Goodman JH, Pinn M, and Brem H. "Treatment of F-98rat glioma with local controlled-release of carboplatin from a biodegradable polymer." American Association of Neurological Surgeons, New Orleans, LA, April, 1991, p. 526. Guerin C, Laterra J, Goldstein GW, and Brem H. "Blood-brain barrier properties of malignant glioma blood vessels: Expression of glucose transporter despite high vascular permeability." American Association of Neurological Surgeons, New Orleans, LA, April, 1991, p. 510. Judy KD, Long DM, and Brem H. "Evaluation of inhibition of Xanthine Oxidase by Allopurinol to reduce oxygen free radical production in cryogenic induced brain edema." American Association of Neurological Surgeons, New Orleans, LA, April 1991, p. 450. Nabors MW, Griffin CA, Zehnbauer BA, Hruban RH, Phillips PC, Grossman SA, Brem H, and Colvin OM. "MDR1 gene expression in human brain tumors." American Association of Neurological Surgeons, New Orleans, LA, April, 1991, p. 521. Dureza C, Olivi A, Domb A, Epstein JI, Lenartz D, Pinn ML, and Brem H. "Brain compatibility of a new biodegradable polymer capable of sustained release of water-soluble agents." American Association of Neurological Surgeons, New Orleans, LA, April 1991, p. 525. Brem H. "Interstitial chemotherapy utilizing polymers for treating brain tumors." Proceedings of the American Association for Cancer Research, 32:488-489, 1991. Judy KD, Olivi A, Domb A, Colvin OM, Brem H. "Controlled release of a cyclophosphamide derivative with polymers is effective against rat gliomas." Congress of Neurological Surgeons, Orlando, Florida, Oct. 1991. Guerin C, Wolff J, Laterra J, Goldstein GW, Brem H. "Glucose transporter expression by 9L glioma vessels is increased by dexamethasone." Congress of Neurological Surgeons, Orlando, FL Oct. 1991. Domb A, Olivi A, Judy K, Brem H. "Anticancer implant for the treatment of brain tumors." ICRF Scientific Conference on Advanced Concepts in Cancer Research, Maleh Hachamishan, Israel, p. 103, 1991 Guerin, C, Laterra J, Masnyk T, Golub LM, Brem H. "Mechanisms of antiangiogenesis: relationship of anticollagenase activity and endothelial cell growth." AANS, San Francisco, CA., April 1992. Weingart J, Olivi A, Brem H. "Tumor growth inhibition by minocycline." American Association of Neurological Surgeons, San Francisco, CA, April, 1992. Brem H, Olivi A, Greenhoot JH, Sisti, M. "Interstitial chemotherapy with BCNU-loaded polymers for the treatment of newly diagnosed malignant astrocytomas: A clinical study." American Association of Neurological Surgeons, San Francisco, CA, April, 1992. Sills AK, Davis JD, Brem H. "Prolongation of survival by interstitial dexamethasone in a rat glioma model." American Association of Neurological Surgeons, San Francisco, CA, April, 1992. Olivi A, Park HC, Epstein JI, Domb AJ, Brem H. "Biocompatible polymers as means to reduce the postoperative epidural scar in a rat model." American Association of Neurological Surgeons, San Francisco, CA, April, 1992. Weingart J, Tamargo R, Brem H. "Minocycline, an anti-angiogenesis inhibitor, inhibits brain tumor growth."American Association for Cancer Research, San Diego, CA, 33:75, 1992. Weingart J, Brem H, Long DM, Zinreich J. "Application of a computer-associated localizing probe using 3-D CT/MRI images in neurosurgery." Congress of Neurological Surgeons, Washington, D.C., October 31 November 5, 1992. Buahin KG, Colvin OM, Brem H. "Interstitial chemotherapy of a brain tumor model: comparison of intratumoral injection versus polymeric controlled release." Congress of Neurological Surgeons, Washington, D.C., October 31 - November 5, 1992. Buahin KG, Ludeman SM, Colvin OM, Brem H. "Efficacy of deuterated 4-hydroperoxycyclophosphamide against a rat glioma model." Congress of Neurological Surgeons, Washington, D.C., October 31 - November 5, 1992. Weingart J, Brem H. "Minocycline, an angiogenesis inhibitor, acts synergistically with carmustine (BCNU) to control 9L gliosarcoma growth. The American Society for Cell Biology, , Denver, Colorado, November 15-19, 1992. Rothman GB, Holliday MJ, Brem H, Mattox DE, Long DM. "Posterior fossa meningiomas: A retrospective review." North American Skull Base Society, Scottsdale, Arizona, 1993, Vol 3, p. 11. Mattox DE, Long DM, Brem H, Bryant N, Trebo S, Zinreich SJ. "Imaging-based computer-assisted surgery for skull base and intracranial surgery: Experience of 81 cases." North American Skull Base Society, Scottsdale, Arizona, 1993, Vol 3, p. 13. Brem H, Cahan MA, Caterall M, Tyler B, Pinn M, Weingart J, Domb A, Ringel I, Hilton J, Colvin M.

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"Inhibition of brain tumor growth by taxol." American Association of Neurological Surgeons, Boston, Massachusetts, p. 479, 1993. Buahin KG, Hilton J, Brem H. "Effect of interstitial chemotherapy with polymeric delivery of a cyclophosphamide congener on glucose metabolism in the brain." American Association of Neurological Surgeons, Boston, Massachusetts, p. 524, 1993. Weingart J, Brem H. "Interstitial delivery of minocycline, an angiogenesis inhibitor, acts synergistically with carmustine (BCNU) to prolong survival in a 9L gliosarcoma intracranial model." American Association of Neurological Surgeons, Boston, Massachusetts, p. 498, 1993. Weingart J, Brem H. "Minocycline, an angiogenesis inhibitor, when delivered interstitially acts synergistically with carmustine (BCNU) to prolong survival in an intracranial 9L gliosarcoma model." American Association for Cancer Research, Orlando, FL, May 19-23, 1993. Walter KA, Cahan M, Brem H. "Taxol's effectiveness against malignant brain tumor cell lines in vitro." American Association for Cancer Research, Orlando, FL, May 19-23, 1993. Arosarena O, Laterra J, Brem H. "Microvascular differentiation in experimental glial tumors." American Association for Cancer Research, Orlando, FL, May 19-23, 1993. Yue NC, Wong D, Yung B, Conti P, Grossman SA, Barker P, Paik C, Hruban R, Nauta H, Brem H, Bryan RN. "Brain tumors: Structural, functional, and pathological cross-correlates." American Society of NeuroRadiology, Vancouver, British Columbia, May 20, 1993. Buahin KG, Colvin OM, Brem H. "Interstitial chemotherapy in a brain tumor model: Comparison of intratumoral injection versus polymeric controlled release." Third Drug Discovery and Development Symposium, San Diego, California, July 22-24, 1993. Weingart J, Tyler B, Colvin OM, Brem H. "Local delivery of camptothecin as a new treatment for malignant brain tumors." Third Drug Discovery and Development Symposium, San Diego, California, July 22-24, 1993. Weingart J, Brem H. "Interstitial delivery of minocycline, an angiogenesis inhibitor, acts synergistically with carmustine (BCNU) to prolong survival in a 9L gliosarcoma intracranial model." Third Drug Discovery and Development Symposium, San Diego, California, July 22-24, 1993. Walter KA, Cahan MA, Domb A, Hilton J, Colvin OM, Brem H. "Taxol delivery by controlled release polymer to treat malignant brain tumors in a rat model." Third Drug Discovery and Development Symposium, San Diego, California, July 22-24, 1993. Blevins LS, Yung BCK, Wong DF, Brem H, Wand G. "In vivo assessment of D2 dopamine receptor density in pituitary adenoma using positron emission tomography." The Endocrine Society, Las Vegas, Nevada, 1993. Sipos EP, Tamargo RJ, Guerin C, Brem H. "Inhibition of tumor angiogenesis by tetracycline." Proceedings of the New York Academy of Science, Tampa, Florida, Jan 19-22, 1994. Wiranowska M, Ransohoff J, Naldu K, Weingart J, Brem H. "Interferon-containing biocompatible polymers for localized cerebral immunotherapy of glioma." Proceedings of the American Association for Cancer Research, San Francisco, Vol 35:491, 1994. White BJ, Brem H, Tamargo RJ. "Permeability of the blood-brain barrier in the postoperative brain." American Association of Neurological Surgeons, San Diego, California, April 9-14, 1994. Utsuki T, Olivi A, Pitha J, Loftsson T, Kristmundsdottir T, Brem H. "Efficacy of carboplatin-hydroxyproply-cyclodextrin complexes against a rat glioma model when locally released from ethycellulose microcapsules." American Association of Neurological Surgeons, San Diego, California, April 9-14, 1994. Walter KA, Cahan MA, Domb A, Hilton JH, Colvin OM, Brem H. "Interstitial taxol for malignant glioma: Efficacy and pharmacokinetics in a rat model." American Association of Neurological Surgeons, San Diego, California, April 9-14, 1994. Loftsson T, Pitha J, Kristmundsdottir T, Utsuki T, Olivi A, Brem H. "Microencapsulation of a carboplatinlodextrin Symposium, Tokyo, Japan, April 1994. Brem H, Piantadosi S, Burger PC, and the Polymer Brain Tumor Treatment Group. "Intraoperative chemotherapy using biodegradable polymers: Safety and effectiveness for recurrent glioma evaluated by a prospective, multi-institutional placebo-controlled clinical trial. The Proceedings of the American Society of Clinical Oncology, Dallas, TX, Vol. 13, p. 174, 1994. Jedlicka AE, DiSilvestre D, Holroyd KJ, Brem H, Burger PC, Levitt RC. "Application of fluorescence-based semi-automated allelotyping to the molecular characterization of tumors. Americal Society of Human Genetics, Montreal, Canada, October 18-22, 1994.

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Brem H. "Drug delivery: Barriers to drug transport and the design of novel therapeutic agents." Journal of Cellular Biochemistry, Supplement 19A, p. 170, 1995. Sampath P, Holliday MJ, Brem H, Long DM. "Immediate and delayed facial paralysis in acoustic tumor surgery. Etiologies and prevention." VI Annual North American Skull Base Society, Naples, Florida, Feb 18-21, 1995. Sipos EP, Witham TF, Ratan R, Baraban J, Brem H. "Buthionine sulfoximine potentiates the antitumor effect of 4-hydroperoxy-cyclophosphamide when delivered locally in the intracranial 9L-glioma mode. American Association for Cancer Research, Toronto, Ontario, Canada, March 18-22, 1995. Choti MA, Saenz J, Yang X, Brem H. "Intrahepatic FudR delivered from biodegradable polymer in experimental liver metastases from colorectal carcinoma." American Association for Cancer Research, Toronto, Ontario, Canada, March 18-22, 1995. Thompson RC, Pardoll DM, Jaffee EM, Tyler BM, Brem H. "Development of a new intracranial tumor model using the murine B16-F10 melanoma." American Association of Neurological Surgeons, Orlando, Florida, April 22-27, 1995. Brem H, Ewend MG, Greenhoot J, Sisti M. "The safety of interstitial chemotherapy with BCNU-loaded polymer in the treatment of newly diagnosed malignant gliomas: a multi-institutional study with three year follow-up. American Association of Neurological Surgeons, Orlando, Florida, April 22-27, 1995. Gibbons MC, Rosenberg JM, Jedlicka AE, Brem H, Burger PC, Levitt RC. "Clinical applications of molecular genetic methods (microsatellite instability) for the pathologic subclassification of gliomas. Association of University Anesthesiologists, San Diego, CA, May 1995. Rosenberg JM, Gibbons MC, Jedlicka AE, Holroyd KJ, Burger PC, Brem H, Levitt RC. "Evidence for FAS antigen as a tumor suppressor gene in gliomas." Association of University Anesthesiologists, San Diego, CA., May 1995. Gibbons MC, Rosenberg J, Jedlicka AE, Brem H, Levitt RC, Burger PC. "Microsatellite instability in gliomas." American Assoc of Neuropathologists, San Antonio, TX, June 6-11, 1995. Williams JA, Dillehay L, Sipos EP, Tabassi K, Civelek AC, Brem H. "Controlled release of radiochemicals from implantable biodegradable polymer devices." Society of Nuclear Medicine, Minneapolis, Minnesoto, June 12-15, 1995. Fung LK, Shin M, Strasser J, Caviston T, Sipos EP, Tyler B, Brem H, Saltzman WM. "Transport of 1,3Bis(1,2-chloroethyl)-1-nitrosourea (BCNU) in the brain following controlled release by a polymer." Controlled Release Society, Seattle, WA, July 30-Aug 2, 1995. Williams J, Dillehay LE, Sipos E, Fahlman C, Tabassi K, Williams J, Wharam M, Brem H. "Implantable biodegradable polymers for radiosensitization of human glioma in vivo." The American Society for Therapeutic Radiology and Oncology (ASTRO). Miami, Florida, Oct 8-11, 1995. Gibbons MC, Sipos EP, Tyler B, Pinn M, Brem H. "The anti-angiogenic agent amiloride inhibits tumor growth and prolongs survival in the rat 9L-glioma model." Congress of Neurological Surgeons, San Francisco, CA, October 14-19, 1995. Gibbons MC, Burger PC, Rosenberg J, Levitt RC, Brem H. "Evidence of mismatch repair in the pathogenesis of GMB." Congress of Neurological Surgeons, San Francisco, CA, October 14-19, 1995. Sills AK, Tyler BM, Brem H. "Intracranial delivery of dexamethasone from a biodegradable polymer." Congress of Neurological Surgeons, San Francisco, CA, October 14-19, 1995. Sipos EP, Tebo SA, Zinreich SJ, Long DM, Brem H. "Intraoperative navigation: In vivo accuracy testing and clinical experience." Congress of Neurological Surgeons, San Francisco, CA, October 14-19, 1995. Storm PB, Thompson RC, Veliuona MA, Tyler B, Brem H. "Intracranial biodistribution of tritiated camptothecin." Congress of Neurological Surgeons, San Francisco, CA, October 14-19, 1995. Storm P, Tyler B, Brem H. "Combination chemotherapy with camptothecin and BCNU: Evidence for in-vitro and in-vivo synergy." Congress of Neurological Surgeons, San Francisco, CA, October 14-19, 1995. Thompson RC, Ewend MG, Jaffee EM, Pardoll DM, Brem H. "Cytokine enhanced antitumor immunotherapy for brain tumors." Congress of Neurological Surgeons, San Francisco, CA, October 14-19, 1995. Ewend MG, Thompson RC, Jaffe E, Pardoll D, Brem H. "Development of immunologic memory against intracranial metastatic melanoma after exposure to interleukin-2-transfected melanoma cells." Congress of Neurological Surgeons, San Francisco, CA, October 14-19, 1995. Brem H. "Controlled delivery of chemotherapy by biodegradable polymers for the treatment of malignant gliomas." Eleventh International Conference on Brain Tumor Research and Therapy, Napa, CA, November 1, 1995.

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Ewend MG, Thompson RC, Pardoll DM, Jaffe EM, Tyler BM, Brem H. "IL-2 and GM-CSF are synergistic in treating intracranial tumors." Eleventh International Conference on Brain Tumor Research and Therapy, Napa, CA, Oct. 31 - Nov, 3, 1995. Storm PB, Brem H. "Intracranial delivery of camptothecin from a biodegradable polymer." Eleventh International Conference on Brain Tumor Research and Therapy, Napa, CA, Oct. 31 - Nov, 3, 1995. Fung LK, Ewend M, Sills A, Sipos E, Thompson R, Brem H, Saltzman WM. “Polymer delivery of carmustine, 4-hydroperoxy-cyclophosphamide and taxol in the monkey brain.” Proceedings of the American Association for Cancer Research, Vol 37:376, 1996. Ewend MG, Anderson R, Tyler BM, Brem H. "Local intracranial delivery of BCNU from biodegradable polymers is effective and safe for the treatment of metastatic intracranial tumors." The American Association of Neurological Surgeons, Minneapolis, MN, April 27-May 2, 1996. Ewend MG, Thompson RC, Anderson R, Pardoll DM, Brem H. "IL-2 and GM-CSF act synergistically in the treatment of intracranial tumors." The American Association of Neurological Surgeons, Minneapolis, MN, April 27-May 2, 1996. Storm PB, Choi S, Brem H. "Treatment implications of topoisomerase I levels in human and rat gliomas." The American Association of Neurological Surgeons, Minneapolis, MN, April 27-May 2, 1996. Anderson R, Ewend MG, Thompson RC, Tyler BM, Brem H. "Intracranial IL-2 generates long-term immunologic memory against subsequent systemic tumor challenges." The American Association of Neurological Surgeons, Minneapolis, MN, April 27-May 2, 1996. Lesniak MS, Ewend MG, Pardoll DM, Brem H. "Local delivery of interleukin-4 (IL-4) prolongs the survival of mice with CNS tumors." The American Association of Neurological Surgeons, Minneapolis, MN, April 27-May 2, 1996. Epstein D, Sills A, Brem H, Collins D, Williams J, Zasloff M. "Selective inhibition of VEGF-stimulated endothelial cells by squalmine." The American Association of Neurological Surgeons, Minneapolis, MN, April 27-May 2, 1996. Sills AK, Epstein DS, Sipos ER, Williams J, Zasloff M, Brem H. "Inhibition of tumor-induced neovascularization by squalamine, a novel angiogenesis inhibitor." The American Association of Neurological Surgeons, Minneapolis, MN, April 27-May 2, 1996. Williams J, Dillehay L, Tabassi K, Sipos E, Brem H. "Intracranial biodegradable polymers for IUdR radiosensitization of human glioma in vivo." American Society of Clinical Oncology, Philadelphia, PA, May 18-21, 1996. Gibbons MC, Burger PC, Rosenberg J, Brem H, Jedlicka AE, DiSilvestre D, Lewis T, Kiser MB, Olivi A, Tamargo R, Carson B, Vogelstein B, Levitt RC. "Glioblastomas (GBMs) associated with germ-line mutations in hMLH1." American Association of Neuropathologists, Vancouver, BC, June 12-16, 1996. Sills AK, Zhao Z, van Wessem K, Crongeyer J, Tyler B, Ewend MG, Leong K, Brem H. "Intracranial delivery of interleukin-2 by microspheres in the treatment of brain tumors. "Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 23(1996) Controlled Release Society, Inc., Kyoto, Japan, July 1996. Kalyanasundaram S, Zhao Z, Sills A, Brem H, Leong KW. “Controlled release for immunotherapy: Analysis of intracranial transport of IL-2.” Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 23(1996) Controlled Release Society, Inc., Kyoto, Japan, July 1996. (Presentation) Shikani A, Domb A, Tyler B, Brem H. "In vitro cytotoxicity of polymer chemotherapy against squamous cell carcinomas of the head and neck. 4th International Conference on Head and Neck Cancer. Toronto, Canada, July 28-August 1, 1996. Samdani A, Watts M, Sills AK, Dawson VL, Brem H. "Nitric oxide produced by glia inhibits growth of human and experimental primary brain tumors." Congress of Neurological Surgeons, Montreal, Canada, Sept 28 - Oct 3, 1996. Samdani A, Sills AK, Zhao Z, Tyler B, Brem H. "Systemic vaccination with GM-CSF microspheres protects against growth of intracranial melanoma." Congress of Neurological Surgeons, Montreal, Canada, Sept 28 Oct 3, 1996. Anderson RC, Ewend MG, Pardoll DM, Jaffee EM, Brem H. "Single site and multiple site vaccinations with GM-CSF secreting cells are equally effective at generating immunity against intracranial B16F10 melanoma. Congress of Neurological Surgeons, Montreal, Canada, Sept 28 - Oct 3, 1996. Ewend MG, Tabassi K, Williams J, Tyler BM, Brem, H. "Intracranial delivery of chemotherapy from biodegradable polymers is effective against experimental brain metastases." Congress of Neurological Surgeons, Montreal, Canada, Sept 28 - Oct 3, 1996.

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Sills Ak, Zhoa Z, Leong K, Tyler B, Crongeyer J, Pardoll D, Brem H. “Intracranial delivery of interleukin-2 prolongs survival in primary and metastatic brain tumor models.” Congress of Neurological Surgeons, Montreal, Canada, Sept 28 - Oct 3, 1996. Williams J, Dillehay L, Sipos E, Fahlman C, Tabassi K, Brem H. "Synthetic implantable biodegradable polymers for IUdR radiosensitization of human glioblastoma In vivo." Congress of Neurological Surgeons, Montreal, Canada, Sept 28 - Oct 3, 1996. Ewend MG, Anderson R, Tabassi K, Tyler BM, Babel KM, Williams JA, Brem H. "Local delivery of BCNU from biodegradable polymer is superior to radiation therapy in treating intracranial melanoma metastases." Surgical Forum, Congress of the American College of Surgeons, San Francisco, CA, Oct. 8, 1996. Williams J, Tabassi K, Sipos E, Brem H. "Polymers for IUdR radiosensitization of experimental glioblastoma." Society of Neuro-Oncology, Santa Fe, NM, Nov. 8-10, 1996. Sills AK, Tyler B, Laterra J, Brem H. "Squalamine blocks endothelial activation by common brain tumor mitogens." Society of Neuro-Oncology, Santa Fe, NM, Nov. 8-10, 1996. Fung LK, Ewend M, Sills A, Sipos E, Thompson R, Watts M, Brem H, Saltzman WM. "Carmustine distribution during polymeric interstitial chemotherapy in the primate brain." Society of Neuro-Oncology, Santa Fe, NM, Nov. 8-10, 1996. Davis JD, Bohan E, Olivi A, Long DM, Weingart JD, Sampath P, Brem H. “Clinical experience with GliadelR” Society of Neuro-Oncology, Santa Fe, NM, Nov. 8-10, 1996. Sills AK, Zhao Z, Ewend MG, Tyler B, vanWessem K, Leong K, Brem H. "Interstitial immunotherapy with interleukin-2 inhibits growth and recurrence of brain metastases." Scientific Assembly of the Southern Medical Association, Baltimore, MD, Nov. 20-24, 1996. Ewend MG, Williams J, Tyler B, Anderson R, Tabassi K, Brem H. "BCNU-polymer and concurrent radiation therapy prolong survival in a malignant glioma model." Scientific Assembly of the Southern Medical Association, Baltimore, MD, Nov. 20-24, 1996. Crongeyer JW, Sills AK, Tyler B, Brem H. "Efficacy of local dexamethasone in the treatment of brain tumors." Scientific Assembly of the Southern Medical Association, Baltimore, MD, November 20-24, 1996. Watts MC, Williams JA, Wharam MD, Herman MG, Nauta H, Brem H. “Stereotactic radiosurgery in the treatment of low-grade glioma.” LINAC Radiosurgery, Lake Buena Vista, Florida, December 11-15, 1996. Sandberg D, Watts M, Tyler B, Brem H. “Cytotoxicity of Taxotere in vitro again human and rat glioma cell lines.” The American Association of Neurological Surgeons, Denver, CO, April 12-17, 1997. Watts M, Sandberg D, Sills A, Bohan E, Brem H. “Chemotherapeutic resistance patterns of tumor specimens from patients with glioblastoma multiforme and glioma cell lines.” The American Association of Neurological Surgeons, Denver, CO, April 12-17, 1997. Watts MC, Lesniak M, Burke M, Samdani A, Brem H. “Controlled release of adriamycin in the treatment of malignant glioma.” The American Association of Neurological Surgeons, Denver, CO, April 12-17, 1997. Ewend MG, Sampath P, William JA, Tyler BM, Sandhu JS, Brem H. “Local delivery of chemotherapy prolongs survival in an intracranial model of metastatic breast carcinoma.” The American Association of Neurological Surgeons, Denver, CO, April 12-17, 1997. Samdani AF, Watts M, Sills AK, Tyler BM, Dawson VL, Dawson TM, Brem H. “Nitric oxide produced by glia inhibits growth of metastatic brain tumor.” The American Association of Neurological Surgeons, Denver, CO, April 12-17, 1997. Yazdi HA, Suh KW, Tyler B, Brem H, Pardoll D, Choti MA. “Therapeutic efficacy of local IL-2 for the treatment of liver melanoma metastasis in the murine model.” American Association for Clinical Research, San Diego, CA, April 12-17, 1997. Burke MD, White MC, Watts MC, Lee JK, Tyler, BM, Posner GH, Brem H. “Hybrid analogs of 1,25dihydroxyvitamin D3 having potent antiproliferative effects against murine tumor cell lines metastatic to the brain.” Tenth Workshop on Vitamin D, Strasbourg, France, May 24-29, 1997. Davis JD, Pinn M, Tyler BM, Williams J, Zasloff M, Brem H. “Inhibition of 9L glioma growth by squalamine, a novel angiogenesis inhibitor.” Research Society of Neurologic Surgeons and British Neurosurgery Research Group, Jackson, Mississippi, June 18-21, 1997. Burke MD, White MC, Lee JK, Watts MC, Tyler BM, Posner GH, Brem H. “Biodegradable polymer wafers impregnated with hybrid analogs of 1,25-dihydroxyvitamin3 for the treatment of intracranial metastases.” Fifth Annual Brown University Symposium on Vitamin D, Sept 7-9, 1997, Providence, RI. Sampath P, Davis JD, Wall ME, Mansukh CW, Tyler B, Brem H, Weingart JD. “Camptothecin analogs: Effect in vitro against glioma cell lines.” Congress of Neurological Surgeons, New Orleans, LA, Sept 27-Oct

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2, 1997. Sampath P, Hanes J, Tyler B, Pardoll D, Brem H. “Combined local delivery of Il-2 and chemotherapy prolongs survival in the treatment of intracranial B16 melanoma.” Congress of Neurological Surgeons, New Orleans, LA, Sept 27-Oct 2, 1997. Davis JD, Pinn M, Tyler BM, Williams J, Zasloff M, Brem H. “In vivo inhibition of 9L glioma growth by squalamine, a novel angiogenesis inhibitor.” Congress of Neurological Surgeons, New Orleans, LA, Sept 27Oct 2, 1997. Hanes J, Sills AK, Zhao Z, Tyler B, Leong K, Pardoll D, Brem H. “Cancer vaccination in the brain: Local cytokine release from biodegradable polymers overcomes tolerance in experimental brain tumors.” Amer Chemical Society & the Controlled Release Society, Conference on Formulation and Drug Delivery II, (presentation) La Jolla, CA, October 5-8, 1997 Kleinberg LR, Silverman, E, Brem H, Wharam MD. “Outcome of oligodendroglioma treatment in the era of modern neuroimaging.” ASTRO meeting, Orlando, FL, Oct 19-22, 1997. Sampath P, Weingart JD, Davis JD, Tyler B, Wani MC, Wall ME, Brem H. “Cytotoxicity of camptothecin analogs in vitro against glioma cell lines.” The Soc. for Neuro-Oncology, Oct 31-Nov 2, 1997. Watts M, Sampath P, Sills A, Ewend M, Bunton T, Dang W, Yazdi H, Pinn M, Tyler B, Brem H. “Safety of intracranial 20% BCNU in PCPP:SA 20:80 polymer in primates.” The Society for Neuro-Oncology, Charlottesville, VA, October 31-November 2, 1997. Brem H, Olivi A, Sampath P, Williams J, Weingart J. “Polymers to treat brain tumors: The Johns Hopkins Experience.” The Society for Neuro-Oncology, Charlottesville, VA, October 31-November 2, 1997. Suh KW, Yazdi HA, Tyler BM, Pardoll DM, Jaffee EM, Brem H, Choti M. “Antitumor effect of GM-CSF producing autologous tumor vaccine on hepatic metastatic colon tumor.” American Association Study of Liver Diseases, Chicago, Nov. 7-11, 1997. Brem H. “Development of drug delivery systems for new approaches in treating brain tumors.” 4th U.S.Japan Symposium on Drug Delivery Systems, Kauai, Hawaii, December 14-19, 1997. Sampath P, Hanes J, Tyler B, Pardoll D, Brem H. “Local IL-2 delivery from genetically engineered cells combined with local chemotherapy is synergistic in the treatment of a murine metastatic brain tumor.” American Association of Neurological Surgeons, Joint Section on Tumors, Philadelphia, PA, April 15-30, 1998, presentation Sampath P, Rhines L, Tyler B, Pinn M, Brem H. “Intracranial delivery of docetaxel (Taxotere) by biodegradable polymers for the treatment of 9L gliosarcoma.” American Association of Neurological Surgeons, Philadelphia, PA, April 15-30, 1998. Sampath P, Rhines L, Brem H. “The Hunterian Neurosurgical Laboratory: the first 100 years.” American Association of Neurological Surgeons, Philadelphia, PA, April 26, 1998.(presentation) Amundson EW, Sampath P, Tyler B, Brem H. Weingart JD. “A mechanistic study of camptothecin analogues in gliomas.” American Association of Neurological Surgeons, Philadelphia, PA, April 15-30, 1998. Carson BS, Weingart JD, Brem H, Biser-Rohrbaugh A, Guarnieri M. “Osmotic pumps for intracranial delivery of anti-tumor therapy.” American Association of Neurological Surgeons, Philadelphia, PA, April 15-30, 1998. Fruehauf JP, Brem H, Parker R, Zonis S. “In vitro synergistic activity of L-Buthionine-S, R-sulfoximine (BSO) with BCNU and temozolomide on human glioblastoma multiforme. American Society of Clinical Oncology, Los Angeles, CA, May 16-19, 1998. Hanes J, Suh K, Tyler B, DiMeco F, Brat D, Choti M, Leong K, Pardoll D, Brem H. “Local interleukin-2 delivery eradicates brain and liver tumors. Proceed. Int’l Symp. Control. Rel. Bioact.Mater., Controlled Release Society, Las Vegas, NV, June 21-26, 1998. Di Meco F, Olivi A, Hanes J, Tyler B, Brat D, Torchiana E, Finocchiaro G, Brem H. “Treatment of established 9L gliosarcoma in rats using syngeneic cells engineered to secrete IL-12.” Congress of Neurological Surgeons, Seattle, WA, Oct 3-8, 1998. Perry VL, Watts M, Burke M, Tyler B, Pinn M, Brem H. “Biodegradable polymeric wafers impregnated with Adriamycin for the treatment of intracranial neoplasms.” Congress of Neurological Surgeons, Seattle, WA, Oct 3-8, 1998. Sampath P, Rhines L, Tyler B, Brem H. “Combination local delivery of docetaxel (Taxotere) and carmustine by biodegradable polymers for the treatment of 9L gliosarcoma.” Congress of Neurological Surgeons, Seattle, WA, Oct 3-8, 1998.

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Sampath P, DiMeco F, Hanes J, Tyler B, Brat D, Pardoll D, Brem H. “An experimental and histopathological study of intracranial paracrine immunotherapy with IL-2 used in combination with local chemotherapy.” Congress of Neurological Surgeons, Seattle, WA, Oct 3-8, 1998. Sampath P, Brem H, Long DM. “Neurosurgery before Harvey Cushing at the Johns Hopkins Hospital (18891904) and the considerable influence of William Halsted. Congress of Neurological Surgeons, Seattle, WA, Oct 3-8, 1998. Rhines LD, Sampath P, Tyler BM, Dolan ME, Weingart J, Brem H. “O6-Benzylguanine potentiates the effects of locally delivered carmustine in an intracranial animal brain tumor model.” Congress of Neurological Surgeons, Seattle, WA, Oct 3-8, 1998. Tyler BM, Hanes J, Sampath P, Pardoll D, Brem H. “Local and systemic memory immune responses following treatment of metastatic brain tumors with allogeneic cells engineered to secrete IL-2.” Congress of Neurological Surgeons, Seattle, WA, Oct 3-8, 1998. Hanes J, Suh KW, Tyler B, Aggarwal A, DiMeco F, Pardoll D, Brem H. “Synthetic cytokine delivery systems for cancer immunotherapy.” Congress of Neurological Surgeons, Seattle, WA, Oct 3-8, 1998. Walter KA, Clatterbuck RE, Burger PC, Brem H. “Meningeal hemangiopericytoma: Predictors of recurrence and the importance of adjuvant radiotherapy.” Congress of Neurological Surgeons, Seattle, Washington, Oct 3-8, 1998. Brem H. “Implantable slow-release polymers for the treatment of brain tumors.” 5th IUBMB Conference on the Biochemistry of Health and Diseases, Jerusalem, Israel Oct 18-22, 1998. Long DM, Gordon T, Etzel A, Burleyson G, Betchen S, Shahrokh S, Brem H. "Evaluation of outcome and cost of craniotomy for tumor performed in regional academic referral centers." The American Academy of Neurological Surgery, Santa Barbara, CA, Nov 4-8, 1998. Hanes J, Suh KW, Tyler B, Choti M, Pardoll D, Brem H. “Controlled delivery of cytokines for anti-tumor immunotherapy.” American Institute of Chemical Engineers, Miama, FL. Nov 15-20, 1998. Di Meco F, Hanes J, Tyler B, Rhines L, Brat D, Torchiana E, Finocchiaro G, Brem H, Olivi A. “Paracrine delivery of IL-12 is effective in the treatment of intracranial 9L gliosarcoma in rats.” The Society for NeuroOncology, San Francisco, CA, November 12-15, 1998. Rhines LD, Sampath P, Dolan ME, Tyler B, Weingart J, Brem H. “Effect of locally-delivered carmustine is enhanced by O6-Benzylguanine in an intracranial brain tumor model.” The Society for Neuro-Oncology, San Francisco, CA, November 12-15, 1998. Rhines LD, Sampath P, Tyler B, Brem H. “Increased doses of BCNU delivered locally via biodegradable polymers result in improved survival in an intracranial human glioma model.” The Society for NeuroOncology, San Francisco, CA, November 12-15, 1998. Hanes J, Sampath P, Ewend MG, Tyler BM, Pardoll D, Brem H. “Local and systemic anti-tumor immunity elicited by intracranial implantation of The Society for Neuro-Oncology, San Francisco, CA, November 1215, 1998. Sampath P, Rhines L, Tyler B, Brem H. “Docetaxel (taxotere) in combination with carmustine delivered via biodegradable polymers for the treatment of 9L gliosarcoma.” The Society for Neuro-Oncology, San Francisco, CA, November 12-15, 1998. Sampath P, Hanes J, DiMeco F, Brat D, Tyler B, Pardoll D, Brem H. “Paracrine immunotherapy with interleukin-2 and local chemotherapy is syngergistic in the treatment of experimental brain tumors.” The Society for Neuro-Oncology, San Francisco, CA, November 12-15, 1998. Perry VL, Watts M, Burke M, Tyler B, Pinn M, Brem H. “Adriamycin impregnated polymers for local treatment of intracranial neoplasms.” The Society for Neuro-Oncology, San Francisco, CA, November 12-15, 1998. (Oral presentation) Brem H, Long D, Gordon T, Bowman H, Etzel A, Burleyson G, Betchen S. “Craniotomy for tumor: Outcomes in high volume versus low volume hospitals.” American Association of Neurological Surgeons, New Orleans, LA, April 24-29, 1999. Perry VL, DiMeco F, Rhines LD, Tyler BM, Finochiaro G, Brem H, Olivi A. “Adriamycin impregnated polymers combined with interleukin -12 for local treatment of intracranial neoplasms.” American Association of Neurological Surgeons, New Orleans, LA, April 24-29, 1999. Perry VL, Burke M, Tyler BM, Brem H. “Adriamycin impregnated PCPP:SA polymers for local therapy of intracranial tumors: toxicity studies.” American Association of Neurological Surgeons, New Orleans, LA, April 24-29, 1999. Di Meco F, Rhines LD, Hanes J, Perry VL, Tyler BM, Finocchiaro G, Brem H, Olivi A. “Effect of locally

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delivered interleukin-12 against intracranial 9L gliosarcoma.” American Association of Neurological Surgeons, New Orleans, LA, April 24-29, 1999. Samdani A, Rhines LD, Adamson DC, Lawson HC, Tyler BM, Brem H, Dawson VL, Dawson TM. “Astroglia mediate cytoxic effects toward brain tumors via a nitric oxide dependent mechanism in vivo. American Association of Neurological Surgeons, New Orleans, LA, April 24-29, 1999. Pomper M, Belden C, Ho A, Hilt DC, DalPan G, Herskovits E, Brem H. “The surgical bed after BCNU polymer wafer placement for recurrent glioma: Serial assessment with CT and MR.” The Society of NeuroRadiology, San Diego, CA, May 22-28, 1999. Hanes J, Sills A, Zhao Z, Tyler B, DiMeco F, Brat D, Leong K, Pardoll DM, Brem H. “Controlled delivery of cytokines from biodegradable polymers for brain tumor immunotherapy.” American Brain Tumor Association, Chicago, IL, July 23-25, 1999. DiMeco F, Rhines LD, Hanes J, Lawson HC, Tyler BM, Aggarwal A, Perry VL, Brem H, Olivi A. “Local delivery of IL-12 by microspheres (IL-12MS) against experimental brain tumors.” Congress of Neurological Surgeons, Boston, MA., October 30 - November 4, 1999. Rhines L, Perry VL, Lawson HC, DiMeco F, Tyler BA, Brem H. “Locally delivered adriamycin (ADR) and interleukin-2 (IL-2) are synergistic in the treatment of intracranial 9L gliosarcoma.” Congress of Neurological Surgeons, Boston, MA., October 30 - November 4, 1999. Rhines L, Lawson HC, Bunton T, Sampath P, Tyler B, Weingart J, Brem H. “O6-Benzylguanine (BG) causes toxicity when administered in conjunction with biodegradable polymers containing increased BCNU loading doses.” Congress of Neurological Surgeons, Boston, MA., October 30 - November 4, 1999. Rhines L, Sampath P, Lawson HC, Betchen S, DiMeco F, Tyler B, Brem H. “Interstitial polymeric delivery of Interleukin-2 (IL-2) combined with BCNU in the treatment of experimental glioma.” Congress of Neurological Surgeons, Boston, MA., October 30 - November 4, 1999. Rhines L, Lawson HC, Samdani A, DiMeco F, Tyler B, Dawson VL, Brem H. “Stimulation of astroglia with interleukin-4, interleukin-12, and interleukin-13: Effects on co-cultured tumor cells.” Congress of Neurological Surgeons, Boston, MA., October 30 - November 4, 1999. Lawson HC, Rhines L, Wetzel M, Tyler BM, Faircloth G, Brem H. “Aplidine and Ecteinascidin-743: Cytotoxicity of two novel anti-tumor agents against primary and metastatic brain tumor lines in vitro.” Congress of Neurological Surgeons, Boston, MA., October 30 - November 4, 1999. DiMeco F, Brem H, Lawson HC, Bohan E, Sampath P, Weingart J, Olivi A. “Interstitial chemotherapy for malignant gliomas: The Johns Hopkins Experience.” The Associazione Italiana di Neuro-Oncologia, VI Congresso, Milan, Italy, November 17-19, 1999. DiMeco F, Rhines LD, Hanes J, Lawson HC, Tyler BM, Aggarwal A, Perry VL, Brem H, Olivi A. “Local IL-12 delivered by biodegradable microspheres (IL-12MS) for the treatment of experimental brain tumors.” The Society of Neuro-Oncology, Scottsdale, AZ, November 18-21, 1999. Lawson HC, Rhines LD, Wetzel M, Tyler BM, Faircloth G, Brem H. “In vitro activity of two novel antitumor agents against primary and metastatic brain tumor lines.” The Society of Neuro-Oncology, Scottsdale, AZ, November 18-21, 1999. Rhines LD, Bunton T, Lawson HC, Sampath P, Tyler BM, Weingart J, Brem H. “Intracranially implanted biodegradable polymers containing increased BCNU loading doses cause toxicity when combined with systemically delivered O6-benzylguanine.” The Society of Neuro-Oncology, Scottsdale, AZ, November 1821, 1999. Rhines LD, Lawson HC, Perry VL, DiMeco F, Sampath P, Tyler B, Brem H. “Synergy of locally delivered adriamycin and interleukin-2 in the treatment of intracranial 9L gliosarcoma.” The Society of NeuroOncology, Scottsdale, AZ, November 18-21, 1999. Rhines LD, Sampath P, Betchen S, Lawson HC, DiMeco F, Tyler B, Brem H. “Combined interstitial delivery of interleukin-2 from microspheres and BCNU from polymer wafers for the treatment of experimental glioma.” The Society of Neuro-Oncology, Scottsdale, AZ, November 18-21, 1999. Rhines LD, Lawson HC, DiMeco F, Samdani A, Tyler B, Dawson VL, Dawson T, Brem H. “Astroglia exposed to interleukini-4, interleukin-12, or interleukin-13 significantly affect the growth of co-cultured tumor cells.” The Society of Neuro-Oncology, Scottsdale, AZ, November 18-21, 1999. Haroun RI, Liu JM, Bettegowda C, Li KW, Tyler BM, Brem H. “Combination chemotherapy and immunotherapy for treatment of experimental intracranial tumors.” American Association for Cancer Research, San Francisco, CA, April 1-5, 2000. Parker R, Kyshtoobayeva A, Mehta R, Brem H, Brem S, Vanier V, Barger J, Fruehauf JP. “In vitro drug

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response (IVDR) and prognostic marker (M) profiles in primary brain tumors.” American Association for Cancer Research, San Francisco, CA, April 1-5, 2000. Haroun RI, Bettegowda C, Khan L, Brem H. “Effect of COL-3, an anti-angiogenesis agent, on rat brain endothelial cell proliferation. The American Association of Neurological Surgeons, San Francisco, CA, April 8-13, 2000. Haroun RI, Khan L, Bettegowda C, Crumpler E, Landa J, Brem H. “In vivo toxicity study of topoisomerase II inhibitor 9-chloro-methyl-ellipticinium acetate via local intracranial delivery.” The American Association of Neurological Surgeons, San Francisco, CA, April 8-13, 2000. Weingart J, Kleinberg L, Brem H, Burger P, Olivi A, Grossman SA. “Necrosis/treatment effect as pathologic finding following Gliadel and cranial radiation (RT) for newly diagnosed glioblastoma multiforme (GBM). American Society of Clinical Oncology, New Orleans, LA. May 20-23, 2000. Walter KA, Li K, Dang W, Troiano G, Tyler B, Brem H. “Paclitaxel: Polilactofate microspheres versus 9L gliosarcoma: efficacy, toxicity, pharmacology.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Haroun RI, Li KW, Tyler B, Guerin C, Zerler B, Brem H. “Chemically modified tetracyclines inhibit solid tumor growth in brain tumor models in vivo.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Haroun RI, Liu JM, Reavey-Cantwell JF, Li KW, Bettegowda C, Tyler B, Brem H. “Systemic immunotherapy (GM-CSF) potentiates the effects of interstitial chemo-immunotherapy in treatment of experimental intracranial tumors. Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Haroun RI, Li KW, Rhines LD, DiMeco F, Lawson HC, Tyler BM, Zahurak M, Piantadosi S, Brem H. “Locally delivered 4-hydro-peroxycyclophosphamide (4HC) potentiates interleukin-2 (IL-2) immunotherapy in the treatment of intracranial 9L gliosarcoma.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Haroun RI, Li KW, Rhines LD, DiMeco F, Lawson HC, Tyler BM, Zahurak M, Piantadosi S, Brem H. “Locally delivered paclitaxel potentiates interleukin-2 (IL-2) immunotherapy in the treatment of experimental malignant glioma. Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Haroun RI, Li KW, Tyler B, Radosta J, Dolan ME, Brem H. Weingart J. “Intracranial delivery of O6Benzylguanine reduces intracranial levels of O6-alkylguanine-DNA alkyltransferase.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Reavey-Cantwell JF, Haroun RI, Zahurak M, Clatterbuck RE, Parker RJ, Fruehoff JP, Brem H. “Evaluation of prognostic value of tumor markers in a cohort of patients with glioblastoma multiforme: tumor profiling.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Li KW, Walter KA, Ngwaba C, DiMeco F, Haroun R, Olivi A, Brem H. “Intraventricular meningiomas: The Johns Hopkins Experience.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. DiMeco F, Cohen SE, Li KW, Tyler BM, Denaro L, Brem H, Olivi A. “Mitoxantrone: Potential for polymer based interstitial treatment of malignant gliomas.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Samdani AF, Rhines L, Adamson C, Lawson HC, Tyler B, Brem H, Dawson VL, Dawson TM. “Astroglia induce cytotoxic effects towards brain tumors via a nitric oxide dependent pathway both in vitro and in vivo.”Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Garonzik IM, Liu J, Sampath P, Wang P, Brem H. “Ectopic recurrence of craniopharyngioma after an interhemispheric, transcallosal approach.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Moriarity JL, Hurt KJ, Brem H, Snyder S. “Molecular cloning and characterization of Bakt 1: A novel transcription factor that interacts with Akt.” Congress of Neurological Surgeons, San Antonio, TX. September 23-28, 2000. Weingart J, Brem H, Grossman SA, Burger P, Wharam M, Kleinberg L. “Gliadel followed by radiotherapy for newly diagnosed malignant glioma: Safety results, pathologic findings, and survival.” I.J. Radiation Oncology, 48(3), p. 256, 2000. Har-el,Y, Rhines L, Sampath P, Haroun R, Brem H, Hanes J. “Polymeric co-delivery of chemotherapeutics and cytokines for the treatment of experimental brain tumors.” American Institute of Chemical Engineers, Los Angeles, CA, November 12-17, 2000. Moriarity JL, Hurt KJ, Brem H, Snyder S. “Molecular cloning and characterization of Bakt 2: A novel

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cytosolic enzyme that interacts with Akt.” The American Association of Neurological Surgeons, Toronto, Canada, April 21-26, 2001. DiMeco F, Li KW, Tyler B, Hanes J, Brem H, Olivi A. “Interleukin D12 delivery by biodegradable microspheres (IL-12 MS) for the treatment of metastatic brain tumors.” The American Association of Neurological Surgeons, Toronto, Canada, April 21-26, 2001. DiMeco F, Li KW, Tyler BM, Wolf A, Denaro L, Brem H, Olivi A. “Toxicity and efficacy of interstitially delivered mitoxantrone for the treatment of malignant brain tumors.” The American Association of Neurological Surgeons, Toronto, Canada, April 21-26, 2001. Tyler BM, DiMeco F, Li KW, Wolf A, Cohen SE, Denaro L, Brem H, Olivi A. “Mitoxantrone: A new agent for the treatment of experimental brain tumors: In vitro assessment.” The American Association of Neurological Surgeons, Toronto, Canada, April 21-26, 2001. Kleinberg L, Weingart J, Olivi A, Burger P, DiMeco F, Brem H, Wharam M. “Outcome with Gliadel followed by radiotherapy in newly diagnosed glioblastoma (GBM).” The American Association of Neurological Surgeons, Toronto, Canada, April 21-26, 2001. Olivi A, Barker F, DiMeco F, Tatter S, Judy K, Burak E, Hilt D, Grossman S, Fisher JD, Brem H, Piantadosi S. “Results of a multicenter Phase I dose escalation study of interstitial BCNU administered via wafers to patients with recurrent malignant glioma.” The American Association of Neurological Surgeons, Toronto, Canada, April 21-26, 2001. Chang SM, Schmidt MH, Barker F, Kasper R, McDermott M, Laws ER, Lillehei K, Bernstein M, Brem H, Sloan A, Berger M, The Glioma Outcome Investigators. “Perioperative complications of first vs second craniotomy among patients enrolled in the Glioma Outcome (GO) Project.” Congress of Neurological Surgeons, San Diego, CA, Sept 29-Oct 4, 2001. DiMeco F, Li KW, Tyler BM, Wolf A, Brem H, Olivi A. “Locally delivered mitoxantrone by biodegradable polymers for the treatment of malignant gliomas.” Congress of Neurological Surgeons, San Diego, CA, Sept 29-Oct 4, 2001. Storm PB, Renard VM, Ye K, Tyler B, Moriarity JL, Brem H. “Noscapine hydrochloride arrests glioma cells at metaphase and is a potential radiosensitizer.” Congress of Neurological Surgeons, San Diego, CA, Sept 29-Oct 4, 2001. Storm PB, Weingart JD, Brem H, Moriarity JL. “Camptothecins in vitro cytotoxicity against gliomas is enhanced by Wortmannin without directly effecting the PI(3)Kinase/Akt Pathway.” Congress of Neurological Surgeons, San Diego, CA, Sept 29-Oct 4, 2001. Storm PB, Moriarity JL, Renard VM, Fischer C, Tyler B, Brem H, Weingart J. “Systemic delivery of CPT11(Irinotecan) fails to enhance systemic or local BCNU efficacy against intracranial 9L gliosarcoma.” Congress of Neurological Surgeons, San Diego, CA, Sept 29-Oct 4, 2001. Storm PB, Renard VM, Moriarity JL, Tyler B, Brem H, Weingart J. “Intracranial delivery of camptothecin against 9L gliosarcoma is enhanced by systemic delivery of BCNU.” Congress of Neurological Surgeons, San Diego, CA, Sept 29-Oct 4, 2001. Renard VM, Storm PB, Ye K, Fischer C, Tyler B, Moriarity JL, Brem H. “Noscapine inhibits gliomas by disrupting microtubule arrays and inducing apoptosis.” Congress of Neurological Surgeons, San Diego, CA, Sept 29-Oct 4, 2001. Gabikian P, Li K, Tyler B, Dillehay L, Dang W, Brem H, Walter KA. “Intracranial delivery of paclitaxel by biodegradable polymer microspheres radiosensitizes malignant gliomas.” Congress of Neurological Surgeons, San Diego, CA, Sept 29-Oct 4, 2001. Gabikian P, Li K, Magee C, Tyler B, Foster F, Dang W, Brem H, Walter KA. “Safety of intracranial paclitaxel: Polilactofate microspheres in dogs.” Congress of Neurological Surgeons, San Diego, CA, Sept 29Oct 4, 2001. Toung TJK, Tyler B, Brem H, Traystman RJ, Kirsch JR, Hurn PD, Bhardwaj A. “Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor.” Society of Neurosurgical Anesthesia and Critical Care, New Orleans, LA., Oct 12, 2001. Toung TJK, Tyler B, Brem H, Traystman RJ, Kirsch JR, Hurn PD, Bhardwaj A. “Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor.” Society for Neuroscience, San Diego, CA, Nov. 10-15, 2001. DiMeco F, Li KW, Tyler B, Wolf AS, Rizzo P, Brem H, Olivi A. “Local delivery of mitoxantrone by biodegradable polymers for the treatment of experimental brain tumors.” World Federation of NeuroOncology Societies/Society for Neuro-Oncology, Washington DC, Nov 15-18, 2001.

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Tyler BM, Margulies Y, Heller J, Huang RC, Brem H. "Tetra-O-methyl Nordihydroguaiaretic Acid (M4N): A novel agent for the interstitial treatment of experimental brain tumors- an in vitro and in vivo assessment." Congress of Neurological Surgeons, Philadelphia, PA, Sept 21-26, 2002. Frazier JL, Wang PP, Tyler B, Pradilla G, Weingart JD, Brem H. "Local intracranial delivery of minocycline for the treatment of 9L gliosarcoma." Congress of Neurological Surgeons, Philadelphia, PA, Sept 21-26, 2002. Frazier JL, Pradilla G, Wang PP, Berry D, Tyler B, Langer R, Brem H. "Intracranial delivery of DNA to brain tumor cells using biodegradable polymers." Congress of Neurological Surgeons, Philadelphia, PA, Sept 21-26, 2002. Lesniak MS, Tyler B, Brem H. "Delivery of local immunotherapy via a Xenogenic cell line." Congress of Neurological Surgeons, Philadelphia, PA, Sept 21-26, 2002. Lesniak MS, Gabikian P, Tyler B, Pardoll D, Brem H. "The role of systemic corticosteroids in the immunotherapy of experimental brain tumors." Congress of Neurological Surgeons, Philadelphia, PA, Sept 21-26, 2002. Pradilla G, Wang PP, Petrangolini G, Case D, Tyler BM, Francescato P, Chillemi F, Brem H, Olivi A, DiMeco F. "Angiogenesis inhibition properties of a novel endostatin analog: in vivo and in vitro characteristics using controlled-release polymers." American Association of Neurological Surgeons, San Diego, CA, April 26-May 1, 2003. Amundson EW, Hdeib A, Tyler BM, Brem H. Weingart J. "SJG-136: A novel agent for the treatment of experimental gliomas: An in vitro study." American Association of Neurological Surgeons, San Diego, CA., April 26-May 1, 2003. Ziewacz J, Amundson EW, Wang P, Tyler B, Brem H. "In vitro and in vivo trials of furegrelate as a novel therapy for malignant gliomas." American Association of Neurological Surgeons, San Diego, CA., April 26May 1, 2003. Pradilla G, Petrangolini G, Legnani FG, Tyler BM, Francescato P, Chillemi F, Brem H, Olivi A, DiMeco F. "Inhibition of angiogenesis in vitro and in vivo by local delivery of a novel endostatin fragment." American Association for Cancer Research, Toronto, Canada, April 5, 2003. Weaver KD, Yohay K, Johns D, Tyler B, Rothstein JD, Brem H. "Gene therapy utilizing an inducible potassium channel decreases in vitro glutamate-mediated human glioma migration." Congress of Neurological Surgeons, Denver, CO, Oct 18-23, 2003 Weaver KL, Yohay K, Johns D, Tyler B, Rothstein JD, Brem H. "Viral delivery of an inducible inwardrectifying potassium channel gene protects murine astrocytes from glutamate-mediated cell death." Congress of Neurological Surgeons, Denver, CO, Oct 18-23, 2003 Wang PP, Khalessi AA, Siddique M, Winter J, Tyler BM, Brem H. "Quinacrine as an adjuvant for intracranial BCNU in the rat intracranial 9L gliosarcoma model. Congress of Neurological Surgeons, Denver, CO, Oct 18-23, 2003 Wang PP, Pradilla G, Ziewacz JE, Winter J, Li KW, Gabikian P, Magee C, Brem H, Walter KA. "Local intracranial delivery of paclitaxel with the PACLIMER delivery system: A dose-escalation toxicity study in a canine model." Congress of Neurological Surgeons, Denver, CO, Oct 18-23, 2003 Amundson EW, Caplan J, Tyler BM, Brem H, Weingart JD. "SJG-136: A novel agent for the treatment of experimental gliomas: An in vivo toxicity and efficacy study." Congress of Neurological Surgeons, Denver, CO, Oct 18-23, 2003 Komotar RJ, Burger PC, Carson BS, Brem H, Olivi A, Tihan T. "Pilocytic and pilomyxoid astrocytomas: Preliminary investigations into cellular and molecular differences." Congress of Neurological Surgeons, Denver, CO, Oct 18-23, 2003 Upadhyay U, Amundson E, Caplan J, Tyler BM, Brem H. "Mechanistic and efficacy studies of nimesulide in combination with BCNU versus experimental gliomas. American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. Upadhyay U, Amundson E, Tyler BM, Fisch A, Brem H. "Efficacy studies of dexamethasone in combination with BCNU versus experimental gliomas." American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. Upadhyay U, Posner S, Tyler BM, Brem H. "In vitro and in vivo and efficacy studies of BCNU combination therapy." American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. Brastianos P, Khalessi A, Tyler B, Wang P, Brem H. "Quinacrine as an adjuvant for intracranial BCNU treatment of glioblastoma." American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004.

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Goodwin C, Pradilla G, Vargas DL, Raza SM, Legnani FG, Tyler BM, Brem H, Olivi A. "Fas-ligand mediates cytotoxicity of peri-tumoral T-lymphocytes in the 9L gliosarcoma model." American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. Hsu W, Pradilla G, Goodwin C, Legnani FG, Tyler BM, Jick J, Olivi A, Brem H. "Local delivery of lactacystin via controlled-release polymers prolongs survivalin a 9L gliosarcoma model." American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. Weaver KD, Yohay K, Haque R, Johns D, Tyler B, Rothstein JD. "Inducible anti-excitotoxic adenoviral gene therapy improves survival in a nude mouse intracranial human glioma model." American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. (oral presentation) Haque R, Weaver K, Yohay K, Tyler B, Zohar Y, Rothstein J, Brem H. "Antagonism of brain-tumor mediated excitotoxic destruction and invasion using a Glutamate release inhibitor." American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. Legnani FG, Pradilla G, Raza S, Tyler BM, Zamora G, DiMeco F, Brem H., Olivi A. "Verapamil administration decreases resistance to mitoxantrone therapy in malignant gliomas and pro-metastatic tumor cell lines in vitro." American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. Slager J, Tyler B, Shikanov A, Domb A, Sidranski D, Brem H. "Controlled release of bioactive antineoplastic RNAse from polyanhydride." Controlled Release Soc, Honolulu, Hawaii, June 12-16, 2004. Pradilla G, Legnani FG, Hsu W, Tyler BM, Gaini SM, DiMeco F, Olivi A, Brem H. "The proteasome inhibitor lactacystin prolongs survival in animals intracranially challenged with 9L gliosarcoma when delivered locally via controlled-release polymers." Congress of Neurological Surgeons, San Francisco, CA., October 16-21, 2004. Pradilla G, Legnani FG, Tyler BM, Gaini SM, Francescato P, Chillemi F, Brem H, Olivi A, DiMeco F. "Combined treatment of systemic BCNU and a locally delivered anti-angiogenic fragment of human endostatin prolong survival in rats challenged intracranially with 9L gliosarcoma." Congress of Neurological Surgeons, San Francisco, CA., October 16-21, 2004. Pradilla G, Mavinkurve G, Legnani FG, Tyler BM, Brem H, Jallo GI. "A novel intramedullary spinal cord tumor model in rabbits." Congress of Neurological Surgeons, San Francisco, CA., October 16-21, 2004. Legnani FG, Hertiz SJ, Pradilla G, Zamora G, Tyler BM, Gaini SM, DiMeco F, Brem H, Olivi A. "Epirubicin inhibits growth in malignant glioma and CNS pro-metastatic tumor cell lines in vitro." Congress of Neurological Surgeons, San Francisco, CA., October 16-21, 2004. Legnani FG, Zamora G, Pradilla G, Hertig SJ, Tyler BM, Gaini SM, DiMeco F, Brem H, Olivi A. "The angiogenesis inhibitor minocycline significantly enhances the cytotoxicity of carboplatin on cell lines of malignant gliomas and CNS metastatic tumors." Congress of Neurological Surgeons, San Francisco, CA., October 16-21, 2004. Legnani FG, Pradilla G, Goodwin C, Vargas DL, Tyler BM, Gaini SM, DiMeco F, Brem H, Olivi A. "T-cell apoptosis surrounding malignant gliomas could be related to decreased anti-tumor immunity and might be caused by tumor-derived Fas ligand in the 9L gliosarcoma model." Congress of Neurological Surgeons, San Francisco, CA., October 16-21, 2004. Tyler B, Kim G, Tupper M, Li Y, Cima M, Langer R, Brem H. "Local Delivery of BCNU through novel microchip technology inhibits tumor growth in the rat 9L flank model." Congress of Neurological Surgeons, San Francisco, CA., October 16-21, 2004. Brem S, Tyler BM, Legnani F, Pradilla G, Fisch A, Brem H. "Local delivery of temozolomide against an experimental malignant glioma model." Congress of Neurological Surgeons, San Francisco, CA., October 1621, 2004. Thai QA, Pradilla G, Legnani F, Brem H, Tamargo R. "Stereotactic implantation of controlled-release iStringi polymers in a human head: Technical report. Congress of Neurological Surgeons, San Francisco, CA., October 16-21, 2004. Mantha A, Legnani FG, Pradilla G, Tyler BM, Brem H, Gokaslan ZL. "A novel model for the study of intraosseous spinal metastasis." Congress of Neurological Surgeons, San Fran, CA., Oct 16-21, 2004. Zamora-Berridi GJ, Legnani FG, Pradilla G, Hertig S, Tyler BM, Brem H. "Cytotoxicity and in vivo safety of carboplatin and minocycline for the treatment of malignant gliomas." AANS/CNS Section on Pediatric Neurological Surgery, San Francisco, CA, December 8-11, 2004. Pradilla G, Mavinkurve G, Legnani FG, Tyler BM, Gosalia N, Pindrik J, Hdeib A, Bagley CA, Brem H, Jallo G. "Toxicity and efficacy study of locally-delivered chemotherapy in a novel rat model of intramedullary spinal cord tumors." AANS/CNS Section on Pediatric Neurological Surgery, San Francisco, CA, December

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8-11, 2004. Pradilla G, Mavinkurve G, Legnani FG, Tyler BM, Gosalia N, Pindrik J, Hdeib A, Bagley CM, Brem H, Jallo G. "A novel model of primary spinal cord tumors in rabbits: functional, radiological and histopathological characterizations." AANS/CNS Section on Pediatric Neurological Surgery, San Francisco, CA, December 811, 2004. Mavinkurve G, Pradilla G, Legnani FG, Tyler BM, Gosalia N, Pindrik J, Hdeib A, Bagley CM, Brem H, Jallo G. "A novel rat model for intramedullary spinal cord glioma." AANS/CNS Section on Pediatric Neurological Surgery, San Francisco, CA, December 8-11, 2004. Legnani FG, Pradilla G, Thai QA, Vargas D, Tyler BM, Zamora G, Gaini SM, DiMeco F, Brem H, Olivi A, Brem H. "Local delivery of verapamil decreases Multi-Drug Resistance in a novel mitoxantrone resistant tumor model in rats." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Legnani FG, Pradilla G, Goodwin C, Vargas DL, Thai QA, Tyler BM, Raza S, Gaini SM,, DiMeco F, Brem H, Olivi A. "Direct activation of the wild-type Fas receptor fails to induce apoptosis in experimental gliomas in vitro." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Pradilla G, Hdeib A, Legnani FG, Williams T, Tyler BM, Caplan JM, Bagley CA, Brem H., Jallo G. "Locally delivered Oncogel (1.5mg/ml Paclitaxel) is safe for intramedullary injections and significantly prolongs onset of paraparesis in a rat model of intramedullary spinal cord tumors." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Caplan JM, Pradilla G, Legnani FG, Hdeib A, Williams T, Mavinkurve G, Bagley CA, Brem H, Jallo G. "Experimental intramedullary gliomas in rats: functional progression and histopathological characterization." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Thai QA, Pradilla G, Legnani FG, Hsu W, Brem H, Tamargo RJ. ""String" polymer implantation in a human cadaver head using stereotactic techniques: Technical report." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Brem S, Tyler B, Legnani F, Pradilla G, Caplan J, Posner S, Brem H. "Combination toxicity studies of temozolomide and BCNU in the rat experimental model." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Williams T, Li Yawen, Tyler BM, Tupper M, Cima M, Langer R, Brem H. "Inhibition of a rat flank gliosarcoma using a chemotherapeutic agent released from a microelectromechanical systems device." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Werner K, Zohar Y, Fisch A, Tyler B, Legnani F, Brem H, Johns D. "Local delivery of IL-12 via a novel GFP adenovirus vector to 9L gliosarcoma cells and rat brain parenchyma." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Martinez C, Slager J, LaDana C, Togioka B, Tyler B, Brem H. "Cytotoxicity of sulindac sulfone against experimental malignant gliomas." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Hertig S, Legnani FG, Pradilla G, Zamora G, Thai QA, Fiorindi A, Tyler BM, Gaini SM, DiMeco F, Brem H, Olivi A. "Epirubicin has potent anti-glioma activity and shows sustained-release when incorporated into a biodegradable controlled-release polymer." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Hdeib A, Pradilla G, Mavinkurve GG, Legnani FG, Caplan J, Williams T, Bagley C, Brem H, Jallo G. "Safety of locally delivered chemotherapy for experimental intramedullary spinal cord tumors in rabbits." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Slager J, Tyler B, Martinez C, Shogen T, Domb A, Brem H. "Controlled release of EGF-Onconase from polyanhydride: Potential treatment for brain tumors." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Fiorindi A, Brem S, Legnani FG, Tyler BM, Pradilla G, Perin A, Longatti P, Brem H, Olivi A. "Oral administration of GPI 15427 in association with BCNU polymer in the treatment of intracranial 9L rat gliosarcoma." American Association of Neurological Surgeons, New Orleans, LA., April 16-21, 2005. Fowers K, Brem H, BruggeW, Hdeib A, Jallo G, Pradilla G, Tyler B, Callahan K. "Preclinical and clinical development of a physically targeted controlled paclitaxel release product, OncoGel®, for local solid tumor management." 12th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, Feb 21-24, 2005. Tyler B, Brem S, Caplan J, Hdeib AM, Legnani FG, Pradilla G, Brem H. "Validation of an experimental

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malignant glioma model with temozolomide and radiation therapy." Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Tyler B, Kim G, Nair S, Caplan J, Tupper M, Li Y, Cima M, Langer R, Brem H. "Polymeric microchip delivery of BCNU inhibits tumor growth in the rat 9L gliosarcoma flank model." Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Caplan J, Hdeib AM, Pradilla G, Tyler B, Legnani FG, Brem H, Jallo GI. "A novel model of infiltrative intramedullary spinal cord tumors in rats." Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Caplan J, Hdeib AM, Pradilla G, Tyler B, Legnani FG, Brem H, Jallo GI. "Local delivery of paclitaxel from the Paclimer/E delivery system for the treatment of intramedullary spinal cord tumors in an experimental rat model. Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Hdeib AM, Caplan J, Pradilla G, Tyler B, Legnani FG, Brem H, Jallo GI. "Locally delivered OncoGel ™ against an established 9L intramedullary spinal cord gliosarcoma delays the onset of paresis in an experimental rodent model. Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Hdeib AM, Caplan J, Pradilla G, Tyler B, Legnani FG, Brem H, Jallo GI. "Local delivery of Paclitaxel with OncoGel ™ delivery system for the treatment of intramedullary spinal cord tumors in an experimental rodent model. Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Pennant W, Slager J, Tyler B, Brem H. "Efficacy of prolonged local delivery of a P13K kinase antagonist in an animal model of intracranial glioma. Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Raza SM, Gallia GL, Weingart JD, Brem H, Olivi A. "Cerebral venous sinus thrombosis: surgical considerations in the management of parasagittal meningiomas invading the superior sagittal sinus. Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Slager J, Tyler B, Bagley K, Levitsky H, Brem H. "Efficacy of toll like receptor-9-ligand CpG oligodeoxynucleotides, released from poly(lactic acid) stereocomplexes, on B16 murine melanoma by stimulating an immune response. Congress of Neurological Surgeons, Boston, MA., Oct 8-13, 2005. Sampath P, Lawson C, Bohan E, Olivi A, Weingart JD, Brem H. "19 years of experience at the Johns Hopkins Hospital with interstitial chemotherapy using Gliadel wafer in the treatment of malignant glioma." Congress of Neurological Surgeons, Boston, MA., October 8-13, 2005. Pearlman J, Slager J, Tyler B, LaDana C, Brem H. “Toxicity and efficacy of a proteasome-inhibitor applied to tumor models in vitro and in vivo.” American Association of Neurological Surgeons, San Francisco, CA, April 22-27, 2006. Tseng K, Yohay K, Tyler B, Rothstein J, Brem H. “Local polymer-based delivery of the non-competitive NMDA receptor antagonist memantine prolongs survival in the 9L rat intracranial glioma model.” American Association of Neurological Surgeons, San Francisco, CA, April 22-27, 2006.. Hdeib A, Tyler B, Legnani F, Caplan J, Reidler J, DiMeco F, Hanes J, Brem H. “Efficacy of locally delivered IL-12 polymer microspheres in an experimental intracranial 9L gliosarcoma rat model. American Association of Neurological Surgeons, San Francisco, CA, April 22-27, 2006. Pennant W, Caplan J, Reidler J, Hdeib A, Pradilla G, Tyler B, Jallo G. “20Gy radiotherapy prolongs paresisfree survival alone and in combination with locally delivered paclitaxel (OncoGel®) in an experimental rat intramedullary spinal cord tumor model.” American Association of Neurological Surgeons, San Francisco, CA, April 22-27, 2006. Bookland M, Nande R, Tyler B, Schluep T, Weingart J, Brem H. “In vitro and in vivo toxicity testing for the prolonged local delivery of a Cyclosert®-camptothecin polymer conjugate in a model of intra-cranial glioma. American Association of Neurological Surgeons, San Francisco, CA, April 22-27, 2006. Hdeib A, Reidler J, Tyler B, DiMeco F, Vick J, Caplan J, Hanes J, Brem H. “Efficacy of controlled local delivery of IL-12 from polymer microspheres in a metastatic melanoma intracranial mouse model.” American Association of Neurological Surgeons, San Francisco, CA, April 22-27, 2006. Baba S, Horti A, Cho S, Brem H, Tyler B, Fox J, Engles JM, Wahl RL. "Distribution of 18F-Adenosine in normal and brain tumor bearing rats." Society of Nuclear Medicine, San Diego, CA., June 3-7, 2006. Tyler BM, Kim G, Tupper M, Li Y, Cima M, Langer R, Brem H. "Local delivery of BCNU through novel microchip technology inhibits tumor growth in the rat 9L flank model." Neuro-Oncology Update, FedEx Institute of Technology, Memphis, TN Aug 24-25, 2006 (Oral Presentation) Legnani FG, Hertig S, Vick J, Pradilla G, Tyler BM, Li K, DiMeco F, Brem H. Olivi A. "Epirubicin inhibits growth in malignant glioma and CNS pro-metastatic tumor cell lines both in vitro and in vivo." Neuro-

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Oncology Update, FedEx Institute of Technology, Memphis, TN Aug 24-25, 2006 (Oral Presentation) Pennant WA, Caplan JM, Reidler J, Hdeib A, Pradilla G, Tyler B, Brem H. Jallo GI. "20 Gy radiotherapy prolongs paresis-free survival alone and in combination with locally delivered Paclitaxel (OncoGel®) in an experimental rat intramedullary spinal cord tumor Model " Neuro-Oncology Update, FedEx Institute of Technology, Memphis, TN Aug 24-25, 2006 (Oral Presentation) Caplan J, Hdeib A, Pradilla G, Tyler BM, Brem H, Jallo G. "A novel model of intramedullary spinal cord tumors and novel approaches to their treatment." Neuro-Oncology Update, FedEx Institute of Technology, Memphis, TN Aug 24-25, 2006 (oral presentation). Hdeib A, Tyler B, Li Khan, DiMeco F, Hanes J, Brem H. "Efficacy of controlled local delivery of IL-12 from polymer microspheres in a metastatic melanoma intracranial mouse model." Neuro-Oncology Update, FedEx Institute of Technology, Memphis, TN Aug 24-25, 2006. Legnani FG, Pradilla G, Thai QA, Tyler BM, DiMeco F, Brem H. Olivi A. "Apoptosis in experimental glioma cells and could be responsible for the apoptosis of T-cell surrounding malignant gliomas in vivo." Neuro-Oncology Update, FedEx Institute of Technology, Memphis, TN Aug 24-25, 2006. Pashalides T, Allen J, Li K, Ludeman SM, Adams DJ, Wani MC, Manikumar G, Colvin OM, Brem H, Tyler B. "Camptothecin analogs demonstrate efficacy in an established intracranial rodent glioma model." Congress of Neurological Surgeons Meeting, Chicago, IL., October 7-12, 2006. Pennant W, Hdeib AM, Tyler B, Brem H, Jallo JI "20 Gy Radiotherapy alone and in Combination with Locally Delivered Paclitaxel (OncoGel®) Prolongs Paresis-Free Survival in an Experimental Rat Intramedullary Spinal Cord Tumor Model." Congress of Neurological Surgeons Meeting, Chicago, IL., October 7-12, 2006. Li KW, Han J, Tyler BM, Brem H. "Inhibition of JAK/STAT pathway by Tyrphostin AG490 reduces glioma proliferation." Congress of Neurological Surgeons Meeting, Chicago, IL., October 7-12, 2006. Brem H. "Directed therapy with polymers for brain tumors." American Academy of Neurological Surgery, Greensboro, Georgia, October 17-21, 2006. Tyler B, Renard V, Kaiser K, Fowers K, Brem H. "20Gy Radiotherapy with Locally Delivered OncoGel (6.0-mg/ml Paclitaxel) Significantly Prolongs Survival in an Experimental Rodent Glioma Model." AANS/CNS Section on Tumors Seventh Biennial Satellite Symposium, Washington, DC, April 13-14, 2007. Marupudi N, Renard V, Tyler BM, Li KW, Brem H, Jallo G. "17-DMAG Inhibits Glioma Tumor Cells and Improves Survival in a Rat Brainstem Glioma Model." AANS/CNS Section on Tumors Seventh Biennial Satellite Symposium, Washington, DC, April 13-14, 2007. Vick D, Hertig S, Tyler BM, Li KW, Renard V, Kosztowski T, Legnani FG, Brem H, Olivi A. "Local Delivery of Epirubicin for the Treatment of an Experimental Rodent Glioma." AANS/CNS Section on Tumors Seventh Biennial Satellite Symposium, Washington, DC, April 13-14, 2007. Marupudi N, Renard VM, Tyler BM., Li KW, Huang RC, Brem H, Jallo G. "Maltose-tri-O-methyl Nordihydroguarietic Acid (maltose-M3N) is a Potential Chemotherapeutic Agent in the Treatment of Gliomas." AANS/CNS Section on Tumors Seventh Biennial Satellite Symposium, Washington, DC, April 13-14, 2007. Pennant WA, Tamargo R, Tyler B, Brem H, Jallo GI. "Single and fractionated radiotherapy dose schedules delay the onset of paresis in an experimental rat intramedullary spinal cord tumor model." American Association of Neurological Surgeons, Washington, DC, April 14-19, 2007. Tyler B, Renard V, Fowers K, Li K, Brem H. A thermal gel depot for intracranial delivery of Paclitaxel (OncoGel®) with 20Gy Radiotherapy Significantly Prolongs Survival in an Experimental Rodent Glioma Model. 2nd International Meeting in Neuro-Oncology, Arezzo, Italy, June 29-30, 2007. Li K, Rege A, Murari K, Li N, Renard V, Tyler B, Thakor N, Brem H. In Vivo Imaging of Intracranial Angiogenesis with LASER Speckle Imaging in Rodents. Congress of Neurological Surgeons, San Diego, September 15-20, 2007. Renard V, Tyler B, Brem S, Li K, Brem H. Combination of Intracranial Temozolomide and BCNU in a Rodent Glioma Model. Congress of Neurological Surgeons, San Diego, September 15-20, 2007. Okonma S, Tyler B, Li K, Renard V, Baird C, Brem H. Combinatorial Treatments with Temozolomide in Experimental Malignant Glioma In Vitro. Congress of Neurological Surgeons, San Diego, September 15-20, 2007. Shira G. Ziegler, Violette M. Renard, Betty M. Tyler, Henry Brem, Alessandro Olivi. Combinatorial Treatments with Epirubicin, Temozolomide, and Radiation Therapy in Experimental Malignant Glioma In Vitro. AANS Annual Meeting, April 26, 2008 - May 1, 2008.

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McGirt MJ, Attenello F, Gathinji M, Than K, Chaichana KL, Datoo G, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa A. Extent of surgical resection is independently associated with survival in patients with malignant and low-grade brain astrocytoma.” AANS Annual Meeting, April 26, 2008 - May 1, 2008. McGirt MJ, Gathinji M, Attenello F, Than K, Chaichana KL, Ruiz AJ, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa A. Persistent outpatient hyperglycemia is independently associated with decreased survival after surgical resection of malignant brain astrocytoma. AANS Annual Meeting, April 26, 2008 May 1, 2008. McGirt MJ, Attenello, Gathinji M, Than K, Chaichana KL, Datoo G, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa A. “Association of preoperative depression and survival after primary sections of malignant brain astrocytoma. AANS Annual Meeting, April 26, 2008 - May 1, 2008. McGirt MJ, Attenello F, Gathinji M, Than K, Chaichana KL, Datoo G, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa A. Association of uncontrolled hyperglycemia with perioperative mortality, length of hospitalization, and healthcare cost for resection of supratentorial brain neoplasms. AANS Annual Meeting, April 26, 2008 - May 1, 2008. Renard V, Tyler B, Vellimana A, Fowers K, Brem H. OncoGel™ (6.3mg/mL Paclitaxel) Combined with Temozolomide and Radiotherapy Significantly Prolongs Survival in an Experimental Rodent Glioma Model. Institute for NanoBiotechnology Symposium. Baltimore, Maryland. May 1-2, 2008. Renard V, Tyler B, Brem S, Li K, Brem H. Combination of Intracranial Temozolomide and BCNU in a Rodent Glioma Model. Institute for NanoBiotechnology Symposium. Baltimore, MD. May 1-2, 2008. Tyler B, Renard V, Wadsworth S, Vellimana A, Brem H. Local Delivery of Rapamycin: An In Vitro and In Vivo Toxicity and Efficacy Study in Experimental Malignant Glioma Model. Congress of Neurological Surgeons. Orlando, Florida, September 20-25, 2008. Renard V, Tyler B, Vellimana A, Fowers K, Brem H. OncoGel™ (6.3mg/mL Paclitaxel) Combined with Temozolomide and Radiotherapy Significantly Prolongs Survival in an Experimental Rodent Glioma Model. Congress of Neurological Surgeons. Orlando, Florida, September 20-25, 2008. Quinones-Hinojosa A, Chaichana KL, McGirt MM, Woodworth GF, Mukherjee D, Shakur S, Datoo G, Brem H. “Persistent outpatient hyperglycemia is independently associated with survival, recurrence, and malignant degeneration following surgery for hemispheric low grade gliomas.” Congress of Neurological Surgeons. Orlando, Florida, September 20-25, 2008 McGirt M, Chaichana KL, Weingart JD, Than KD, Attenello F, Olivi A, Brem H, Quinones-Hinojosa A. “Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma.” Congress of Neurological Surgeons. Orlando, Florida, September 20-25, 2008 Coddington LT, Renard VM, Tyler BM, Ayukawa Y, Gutenkunst JR, Michaud RM, Chipkin RE, Brem H, Rothstein JD, Sattler RG. GLT-1 upregulation with small molecule compounds prevents tumor growth in animal models of experimental glioma. Society for Neuroscience, Washington DC, Nov 15-19, 2008. Mehta V, Tyler B, Wadsworth S, Renard-Recinos V, Do H, Rosenblatt J, Li KW, Vellimana AK, Brem H. “Local Delivery of Rapamycin: An in vitro and in vivo Toxicity and Efficacy Study in Experimental Malignant Glioma Model.” Congress of Neurological Surgeons, New Orleans, LA, Oct 24-29, 2009. Rege A, Seifert A, Li K, Tyler B, Hertig S, Basaldella L, Bekelis K, Thakor N, Brem H. Monitoring Angiogenesis in Rodent Brains with Laser Speckle Imaging. Congress of Neurological Surgeons, New Orleans, LA, October 21-26, 2009. Grossman R, Rudek MA, Brastianos H, Mehta V, Zadnik P, Hwang L, Tyler B, Brem H, Blakely J. The impact of bevacizumab on intratumoral temozolomide concentrations in a U87 rat glioma model. AANS, Philadelphia, PA, May 1-5, 2010. Grossman R, Kashi, Tyler, B, Brem H. Linking Antibody Fc Domain to Endostatin improves the standard treatment of Experimental Glioma, AANS, Philadelphia, PA, May 1-5, 2010. Grossman, R, Kashi, Tyler, B, Brem H. Local Delivery of Fc-endostatin Improves the Standard Treatment of Experimental Glioma. Congress of Neurological Surgeons, San Francisco, California, Oct 16-23, 2010. Upadhyay U, Scott AW, Tyler B, Patta Y, Masi M, Basaldella L, Grossman R, Bekelis K, Brem H, Cima M, Langer R. In Vivo Efficacy and Molecular Analysis of Microcapsule-Driven Delivery of Temozolomide to Experimental High Grade GliomaL Preliminary Results. Congress of Neurological Surgeons, San Francisco, California, Oct 16-23, 2010. Khan U, Tyler BM, Pradilla G,Aprhys C, Nance E, Basaldella L, Kumar A, Hanes J, Brem H, Olivi A. FasL Gene Knock-down Therapy Enhances the Anti-Glioma Immune Response. Royal College of Medicine, Surgery Section MIA prize, 2010.

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Latimer K , Pendelton C, Olivi A, Cohen-Gadol AA, Brem H, Quinones-Hinojosa A. Historical Perspective on Medical Errors: Documentation of Surgical Mishaps at the Dawn of Neurological Surgery. CNS, San Francisco, CA, October 16-21, 2010. Tyler BM, Grossman R, Yurter A, Huey L, Chiang C, Wicks RT, Brem H. Efficacy of Locally Implanted and Systemic Temozolomide with Avastin and Radiation Therapy in an Experimental Glioma Model. American Association of Neurological Surgeons, Denver, CO, April 9-13, 2011. Tyler BM, Grossman R, Patta Y, Upadhyay U, Huey L, Azadi J, Cima M, Brem H. Systemically Delivered Doxil Increases Survival in Both an Intracranial Gliosarcoma Model and an Intracranial Metastatic Breast Cancer Model in Rodents. American Association of Neurological Surgeons, Denver, CO, April 9-13, 2011. Tyler BM, Yoda Patta Y, Grossman R, Upadhyay U, Azadi J, Wicks RT, Cima M, Brem H. Efficacy of Locally Implanted Temozolomide Microcapsules in an Intracranial Metastatic Breast Cancer Model. American Association of Neurological Surgeons, Denver, CO, April 9-13, 2011. Grossman R, Tyler BM, Blakely J, Rudek MA, Zadnik P, Khan U, Pathak A, Brem H. The impact of Cediranib, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, on Intratumoral Temozolomide Concentration in U87 Gliomas. American Association of Neurological Surgeons, Denver, CO, April 9-13, 2011. Tyler BM, Pradilla G, Aprhys C, Khan U, Nance E, Basaldella L, Kumar A, Hanes J, Brem H, Olivi A. FasL Gene Knock-down Therapy Enhances the Anti-Glioma Immune Response. American Association of Neurological Surgeons, Denver, CO, April 9-13, 2011. Zhou J, Wang S, Tyler BM, Grossman R, Tryggestad E, Ford E, Armour M, Yan K, Lal B, van Zijl P, Laterra J. Predicting glioma Response to Radiotherapy with Amide Proton Transfer (APT) MRI. International Society for Magnetic Resonance in Medicine (ISMRM), Montreal, Quebec, May 7-13, 2011. Wicks RT, Yoshida J, Zambrano A, Tyler BM, Javaherian K, Grossman R, Peter Gehlbach P, Daoud YJ, Brem H, Stark WJ. Inhibition of Corneal Neovascularization by Fc-endostatin. ARVO, Orlando, FL, May 2011. Upadhyay U, Patta Y, Tyler BM, Spencer K, Wicks RT, Van Shaik G, Brem H,Cima M, Langer R. Spatial Distribution of Drug Exposure and Cleaved Caspase-3 Expression in an Experimental Model of Brain Metastases following Microcapsule-Driven Intracranial Doxorubicin Delivery. Congress of Neurological Surgeons, Washington DC, October 2011. Wicks RT, Patta Y, Tyler BM, Upadhyay U, Martin KL, Langer R , Cima M, Brem H. Efficacy of Intracranial Microcapsule Delivery of Temozolomide compared to Systemic Therapy in a Model of Metastatic Breast Carcinoma. Congress of Neurological Surgeons, Washington DC, October 2011. Wicks RT, Yoshida J, Zambrano A, Tyler BM, Javaherian K, Grossman R, Gelbach P, Daoud Y, Stark WJ, Brem H. Inhibition of Angiogenesis by Fc-endostatin. Congress of Neurological Surgeons, Washington DC, October 2011. Zhang K, Wicks RT, Pradilla G, Tyler BM , Brem H, Kang JU. Intra-operative Optical Coherence Tomography (OCT) Guided Tumor Resection. Congress of Neurological Surgeons, Washington DC, October 2011 Bender M, Pradilla G, Wicks RT, Garzon-Muvdi T, Jarso S, Brayton C, Weingart J, Brem H, Tyler BM. Toxicity study of Temozolomide polymers in cynomolgus monkeys. Drug Discovery in Academia Conference, Baltimore, MD October 18, 2011. Wicks RT, Bow H, Schildhaus N, Salditch Q, Hutt M, Azadi J, Brem H, Tyler BM. Combined Intracranial Delivery and Efficacy of 3-Bromopyruvate and Dichloroacetate. Drug Discovery in Academia Conference, Baltimore, MD October 18, 2011. Bow H, Salditch Q, Murray L, Xing J, Schildhaus N, Ye X, Zhang Y, Tyler BM, Brem H. Antiangiogenesis agent minocycline as adjuvant therapy to oral temozolomide and radiotherapy in intracranial 9L glioma. Drug Discovery in Academia Conference, Baltimore, MD October 18, 2011. Wicks RT, Martin K, Bender M, Morano L, Tok S, Yurter A, Brem H, Tyler B. Tolerability and efficacy of combined local, polymeric temozolomide delivery with systemic temozolomide in a rodent glioma model. Drug Discovery in Academia Conference, Baltimore, MD October 18, 2011. Tyler BM, Grossman R, Patta Y, Upadhyay U, Huey L, Azadi J, Cima M, Brem H. Systemically Delivered Doxil Increases Survival in Both an Intracranial Gliosarcoma Model and an Intracranial Metastatic Breast Cancer Model in Rodents. Discovery in Academia Conference, Baltimore, MD October 18, 2011. Tok S, Tyler BM, She AS, Robins N, Thomale UW, Jallo G. Local Delivery of Celingitide by Osmotic Pump Significantly Increases Survival in a Rat Brainstem Glioma Model. Discovery in Academia Conference, Baltimore, MD October 18, 2011.

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Wicks RT, Masi B, Bow H, Tyler BM, Martin KL, Wicks EE, Cima C, Langer R, Brem H. Biocompatibility and Efficacy of Intracranial Microchip Delivery of Temozolomide in a Rat Model of Glioma. Discovery in Academia Conference, Baltimore, MD October 18, 2011. Belcaid BZ, Phallen JA, Zeng J, See AP, Albesiano E, Durham NM, Tyler BM, Brem H, Pardoll DM, Drake C, Lim M. Stereotactic Radiosurgery Combined with Double Immunotherapy with anti-CTLA-4 and anti-41BB Yields Long-term Survival and Protective Antitumor Response in a Mouse Orthotopic Glioblastoma Model. Society for Neuro Oncology, Orange County, CA. November 2011. Bow H, Salditch Q, Murray L, Xing J, Schildhaus N, Ye X, Zhang Y, Tyler BM, Brem H. Antiangiogenesis agent minocycline as adjuvant therapy to oral temozolomide and radiotherapy in intracranial 9L glioma. American Association of Neurological Surgeons, Miami, FL. April 14-19, 2012. Bender M, Pradilla G, Wicks RT, Garzon_Muvdi T, Jarso S, Brayton C, Weingart J, Brem H, Tyler BM. Toxicity study of temolzolomide polymers in cynomolgus monkeys. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Wicks RT, Tyler BM, Zhang I, Azadi J, Hutt M, Xing J, Murray L, Bow H, Brem H. Controlled release of glioma metabolic inhibitors in combination with temozolomide and radiation therapy. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Wicks RT, Martin K, Bender M, Morano L, Tok S, Yurter A, Brem H, Tyler B. Tolerability and efficacy of combined local, polymeric temozolomide delivery with systemic temozolomide in a rodent glioma model. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Wicks RT, Tyler BM, Bow H, Schildhaus N, Salditch Q, Hutt M, Azadi J, Brem H. Combined Intracranial Delivery and Efficacy of 3-Bromopyruvate and Dichloroacetate. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Wicks RT, Zhang K, Huang Y, Hutt M, Bow H, Ruzevick J, Kang J, Tyler BM, Jallo G, Brem H, Pradilla G. Optical coherence tomography (OCT) imaging of carotid artery calcifications in a murine model of atherosclerosis. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Wicks RT, Zhang I, Tok S, Martin K, Upadhyay U, Patta Y, Yurter A, Brem H, Tyler BM. Combination therapy of doxil with temozolomide, radiation therapy, and BCNU in an experimental Glioma Model. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Wicks RT, Masi B, Bow H, Tyler BM, Martin KL, Wicks EE, Cima C, Langer R, Brem H. Biocompatibility and Efficacy of Intracranial Microchip Delivery of Temozolomide in a Rat Model of Glioma. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Wicks RT, Zhang K, Huang Y, Tyler BM, Brem H, Jallo G, Kang J, Pradilla G. Development and evaluation of a hand-held optical coherence tomography (OCT) imaging probe for intra-operative use at the skull base. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Zeng J,See A, Phallen J, Belcaid Z, Durham N, Meyer C, Albesiano E, Pradilla G, Ford E, Hammers H, Tyler B, Brem H, Tran P, Pardoll D, Drake, C, Lim M. Combining Anti-PD-1 Immunotherapy with Stereotactic Radiosurgery in a Mouse Orthotopic Glioma Model. American Associaton of Neurological Surgeons. Miami, FL. April 14-19, 2012. Bow H, Hwang Y, Salditch Q, Murray L, Xing J, Schildhaus N, Ye X, Zhang Y, Tyler BM, Brem H. Antiangiogenesis agent minocycline as adjuvant therapy to oral temozolomide and radiotherapy in intracranial 9L gliosarcoma. Congress of Neurological Surgeons, October 6-10, 2012. Chicago, IL. Bow H, Masi B, Wicks RT, Hwang Y, Cima M, Langer R, Tyler BM, Brem H. Microchip-based intracranial temozolomide delivery in a 9L rat gliosarcoma model. Congress of Neurological Surgeons, October 6-10, 2012. Chicago, IL. Gallia G, Tyler BM, Brem H. New Approaches to Treating Brain Tumors. 6th International Conference on Bioengineering and Nanotechnology. June 24th-27th, 2012. University of California, Berkley Campus. Jin Y, Watson J, Polston C, Alsaeedi N, Trink E, Picker T, Curtis C, Velarde C, Brem H, Tyler BM. “Local Delivery 2-Deoxy-D-Glucose as a Possible Therapeutic Option: A Preclinical Study,” 81st American Association of Neurological Surgeons Annual Scientific Meeting, New Orleans, Louisiana, April 27-May 1, 2013. Watson J, Srivastava G, Bai R, Curtis C, Schildhaus N, Swedlow N, Taylor M, Trink E, Brem H, Riggins GJ, Tyler BM. “Efficacy of the Orally Delivered, Anti-Parasitic, Mebendazole, in an Intracranial Rodent Gliosarcoma Model,” 81st American Association of Neurological Surgeons Annual Scientific Meeting, New Orleans, Louisiana, April 27-May 1, 2013. Alsaeedi N, Srivastava G, Jin Y, Schildhaus N, Polston C, Picker T, Taylor M, Velarde C, Brem H, BM

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Tyler. “Efficacy of Locally Delivered Rapamycin in a Rodent Gliosarcoma Model,” 81st American Association of Neurological Surgeons Annual Scientific Meeting, New Orleans, Louisiana, April 27-May 1, 2013. a386 Bydon M, Ma TM, Xu R, Macki M, Weingart J, Olivi A, Gokaslan ZL, Tamargo R, Brem H, Bydon A. Surgical Management of Craniocervial Junction Meningiomas: A Series of 22 Consecutive Patients. Congress of Neurological Surgeons 2013 Annual Meeting. San Francisco California, October 19 – 23, 2013 a387 Huang J, Coon A, Lim M, Quinones-Hinojosa A, Weingart J, Colby G, Olivi A, Liauw J, Lina I, Brem H. Multidisciplinary Approach for Improved Outcomes in Secondary Cranial Reconstruction: Introducing the Pericranial-onlay Cranioplasty Technique. 82nd AANS Annual Scientific Meeting , San Francisco, April 5-9, 2014 a388 A Mangraviti, N Abu-Bonsrah, M Seng, C Polston, T Raghavan, L Williams, D Schriefer, A Wu, D Coplon, H Brem, A Olivi, B Tyler. 2-Deoxy-D-Glucose -Induced Cytotoxicity in Malignant Glioma Cells. 2014 AANS Annual Scientific Meeting, April 5, 2014 – April 9, 2014 , San Francisco, CA. a389 A Mangraviti, Y Jin, M Seng, A Huang, G Hsu, J Wooley, M Pedone, I Paldor, C Velarde, A Olivi, H Brem, B Tyler. Dichloroacetate Acid Enhances the Antitumor Efficacy of Carboplatin in the F98 Glioma Model. 2014 AANS Annual Scientific Meeting, April 5, 2014 – April 9, 2014 , San Francisco, CA. a390 A Mangraviti, M Seng, N Abu-Bonsrah, T Raghavan, L Williams, C Polston, M Itzoe, D Schriefer, N Ram, H Brem, A Olivi, B Tyler. Local Delivery of 2-Deoxy-D-Glucose as a Possible Therapeutic Option to Increase the Efficacy of TMZ in Malignant Glioma: A Preclinical Study. 2014 AANS Annual Scientific Meeting, April 5, 2014 – April 9, 2014 , San Francisco, CA. a391 Iddo Paldor, Nicolas Bonne, Jaishri Blakeley, Marco Giovannini, Henry Brem and Betty M. Tyler. Nilotinib and lapatinib are effective for treatments of NF2 related schwannomas in the mouse xenograft model. 2014 NF Conference, June 7-10, 2014, Washington D.C. a392 Iddo Paldor, Nicolas Bonne, Antonella Mangraviti, Jaishri Blakeley, Marco Giovannini, Henry Brem and Betty M. Tyler. Nilotinib and lapatinib are effective for treatments of NF2 related schwannomas in the mouse xenograft model. 2014 Congress of Neurological Surgeons Annual Meeting, October 18-22, in Boston, Massachusetts. a393 Antonella Mangraviti, Sadhak Sengupta, Michael Seng, Leon Pinheiro, David Rowshanshad, Iddo Paldor, Betty Tyler, Prakash Sampath, Alessandro Olivi, Henry Brem. Assessment of IL13Rα2-dependent tumor aggression in an immunocompetent glioma animal model. 2014 Congress of Neurological Surgeons Annual Meeting, October 18-22, in Boston, Massachusetts. a394 Antonella Mangraviti, Yike Jin, Jay Sy, Yuan Wang, Tula Raghavan, Lindsey Hastings-Spaine, Alessandro Olivi, Betty Tyler Henry Brem. Efficacy of intracranial delivery of dichloroacetate and carboplatin via an lcp polymer microcapsule device in an experimental glioma model. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, Florida, November 13-16, 2014. a395 Antonella Mangraviti, Sadhak Sengupta, Iddo Paldor, David Rowshanshad, Prakash Sampath, Alessandro Olivi, Betty Tyler, and Henry Brem. Overexpression of IL13Ra2: assessment of pro-aggressive and proinvasive phenotypes of malignant glioma in a syngeneic animal model. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, Florida, November 13-16, 2014. a396 Antonella Mangraviti, Stephany Tzeng, Michael Seng, Sara Abbadi, Kristen Kozielski, Paula Schiapparelli, Olindi Wijesekera, Rachel Sarabia-Estrada, Henry Brem, Betty Tyler, Alessandro Olivi, Jordan Green, Alfredo Quinones-Hinojosa. BMP4-Secreting hAdMSCs Engineered With Nanoparticles: A Non-Viral MSCBased Therapy For Glioblastoma. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, Florida, November 13-16, 2014. a397 Dimitrios Mathios , Jillian Phallen, Chul-Kee Park ,1, Christopher Jackson, Sarah Nicholas, Betty Tyler, Drew Pardoll, Henry Brem, Michael Lim. PD-1 blockade shows synergistic survival, anti-tumor immune response and long-term memory with interstitial but not systemic chemotherapy: study in a murine glioblastoma model. 19th Annual Scientific Meeting of the Society for Neuro-Oncology, Miami, Florida, November 13-16, 2014. a398 Buaron N, Mangraviti A, Yuan Wang Y, Ann Liu A, Pedone, M Sankey E, Chintacunta R, Traitel T, Goldbart R, Brem H, Tyler B, Joseph Kost. In vivo Safety Study Assessing the Effect of Ultrasound and Modified Pectic Galactan/DNA Complexes as a New Approach for Treating Brain Cancer. AANS/CNS Section on Tumors, 11th Biennial Satellite Symposium, Washington D.C, May 1-2, 2015. a399 Mangraviti A, Raghavan T, Sankey E, Liu A, Wang Y, Schriefer D, Brem H, Olivi A, Tyler B. Acriflavine: A new HIF-1 Inhibitor for the Therapeutic Treatment of Malignant Glioma. AANS/CNS Section on Tumors Updated 10/26/2015

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11th Biennial Satellite Symposium, Washington, D.C.on May 1-2, 2015. Mangraviti A, Tzeng S, Kozielski K, Wang Y, Jin Y, Gullotti D, Pedone M, Buaron N, Liu A, Wilson D, Hansen S, Rodriguez F, Gao GD, DiMeco F, Brem H, Olivi A, Tyler B, Green J. Brain tumor non-viral gene therapy via polymeric nanoparticle extends survival in vivo. AANS/CNS Section on Tumors, 11th Biennial Satellite Symposium, Washington D.C., May 1-2, 2015. Pinheiro L, Paldor I, Vigilar MV, Itzoe M, Rowshanshad D, Brem H, Tyler B. Captopril, an ACE Inhibitor, as an Effective Adjuvant Therapy with Temozolomide in an Intracranial Tumor Model. AANS/CNS Section on Tumors 11th Biennial Satellite Symposium, Washington, D.C.on May 1-2, 2015. Paldor I, Pinheiro L, Vigilar MV, Itzoe M, Rowshanshad D, Brem H, Tyler B. Captopril, an ACE Inhibitor, as an Effective Adjuvant Therapy with Temozolomide in an Intracranial Tumor Model.The 14th Asian Australasian Congress of Neurological Surgeons, Jeju Island, Korea, 15 - 18 April 2015. Mathios D, Hwang T, Phallen J, Bettegowda C, Ha P, Burger P, Brem H, McDonald K, Park CK, Lim M. Investigation of epigenetic based inter-tumoral heterogeneity identifies novel ZMIZ1 gene as a biomarker of cancer patient survival in multiple tumor types. AACR 106th Annual Meeting, Philadelphia, PA ; April 1822, 2015. Sankey EW, Lopez J, Zhong S, Jusue-Torres I, Liauw J, Huang J, Brem H, Gordon C. Perioperative Anticoagulation Increases the Risk of Complications after Cranioplasty. Plastic & Reconstructive Surgery: May 2015 - Volume 135 - Issue 5S - p 36–37 Jackson S, Anders N, Mangravitti A, Brem H, Tyler B, Rudek M, Grossman S. TR-09 The effect of regadenoson-induced transient disruption of the blood brain barrier on temozolomide delivery to rat brain parenchyma. Society of NeuroOncology, San Antonio TX Nov 19-22, 2015; 17(3). Lopez J, Zhong S, Sankey EW, Swanson EW, Susarla H, Torres I, Huang J, Brem H, Auwaerter P, Gordon C. Time Interval Reduction for Delayed Implant-Based Cranial Reconstruction in the Setting of Previous Bone Flap Osteomyelitis. Podium Presentation, The 95th Annual Northeastern Society of Plastic Surgery (NESPS) Annual Meeting, Philadelphia, PA. September 17-20, 2015. Lopez J, Zhong S, Sankey EW, Swanson EW, Susarla H, Jusué-Torres I, Huang J,Brem H, Auwaerter PG, Gordon CR. Time Interval Reduction for Delayed Implant-based Cranioplasty Reconstruction in the Setting of Previous Bone Flap Osteomyelitis. Podium Presentation ,16th Congress of International Society of Craniofacial Surgery. Tokyo, Japan. September 14-18, 2015.

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