Idea Transcript
박현호 (Hyun Ho Park) Ph.D. A.
Academic Backgraound/Education
Year
Degree
2007 2002 2000
박사 석사 학사
B.
Research Experience
2018- 현재 2008- 2018 2007-2008
C.
코넬대학교 (생화학 및 단백질 구조학) 광주과학기술원 (생명과학과) 경북대학교 (유전공학과)
중앙대학교 약학대학 부교수 (단백질구조/표적신약 연구실) 영남대학교 생명공학부 분자생명과학전공 전임강사, 조교수, 부교수 스탠포드대학 HHMI Post-Doc, Dr. Chris Garcia’s lab
Awards/Honors/Fellowships
한국분자세포생물학회 2019년 Blue Ribbon Lecture 수상자 선정 과학기술정보통신부 국가연구개발사업 예비타당성조사 자문워원 (2018~ 현재) 한국과학기술기획평가원 기술수준평가핵심전문위원 (2018~ 현재) 한국연구재단 핵심평가위원 (2017~ 현재) 한국해양과학기술진흥원 전문평가위원 (2017~현재) “Apoptosis” 편집위원 (2013~ 현재) 영남대학교 연구우수교원상 (2015) 과기부 선정 우수연구원상 (2007)
D.
Publications
8. Sunghwan Kim, Chang Min Kim, Young-Jin Son, Jae Young Choi, Rahel K. Siegenthaler, Younho Lee, Tae-Ho Jang, Jaeyoung Song, Hara Kang, Chris A. Kaiser, and Hyun Ho Park (2018). Molecular basis of maintaining an oxidizing environment under anaerobiosis by soluble fumarate reductase. Nature Communication in press 7. Hyun Ho Park (2018). Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain Cell Death and Differentiation in press 6. Chang Min Kim, Young-Jin Son, Sunghwan Kim, Seo Yun Kim, and Hyun Ho Park (2017 11). Molecular basis for unique specificity of human TRAF4 for platelet GPIbβ and GPVI. PNAS 114 (43): 11422-11427 5. Jae Young Choi, Qi Qiao, Se-Hoon Hong, Chang Min Kim, Jae-Hee Jeong, Yeon-Gil Kim, Yong-Keun Jung, Hao Wu, and Hyun Ho Park (2017 07 11). CIDE domains form functionally important higher-order assemblies for DNA fragmentation. PNAS 114 (28): 7361-7366
4. Jong Hwan Yoon, Young-jin Cho and Hyun Ho Park (2014 01). Crystal structure of TRAF4 TRAF domain with coiled-coil domain and its implications in TRAF4 signaling pathway. Acta Crystallograph Sect D Biological Crystallography 70: 2-10 3. Dongseop Kwon, Jong Hwan Yoon, Soo-Yong Shin, Tae-Ho Jang, Hong-Gee Kim, Insuk So, Ju-Hong Jeon and Hyun Ho Park (2012). A comprehensive manually curated protein-protein interaction database for the Death Domain superfamily. Nucleic Acids Res. 40 (D1): D331-D336 2. Hynu Ho Park, Emmanuelle Logette, Stefan Raunser, Solange Cuenin, Thomas Walz, Jurg Tschopp, and Hao Wu. (2007). Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex. Cell 128:533-546 1. Hyun Ho Park, Yu-Chih Lo, Su-Chang Lin, Liwei Wang, Jin Kuk Yang and Hao Wu. (2007). The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation. Annu. Rev. Immunol. 25: 561-586
2018 123. Hyun Ji Ha and Hyun Ho Park (2018). Helical assembly of Drep2 CIDE domain confirmed by mutation analysis Scientific Reports in press (NRF-2015R1D1A1A01057591 and NRF2018R1A2B2003635) 121. Hyun Ji Ha and Hyun Ho Park (2018). Identification and analysis of dominant negative mutants on RIP1 DD that disrupt RIPoptosome core formation Molecular Biology Reports (NRF-2017M3A9D8062960, HI17C0155 and 2018CAU) 120. Hyun Ho Park (2018). Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain Cell Death and Differentiation in press (NRF2017M3A9D8062960, NRF-2018R1A2B2003635, NRF-2018R1A4A1023822, and HI17C0155) 120. Sunghwan Kim, Chang Min Kim, Young-Jin Son, Jae Young Choi, Rahel K. Siegenthaler, Younho Lee, Tae-Ho Jang, Jaeyoung Song, Hara Kang, Chris A. Kaiser, and Hyun Ho Park (2018 11 19). Molecular basis of maintaining an oxidizing environment under anaerobiosis by soluble fumarate reductase. Nature Communication (NRF-2017M3A9D8062960, NRF2018R1A2B2003635, and HI17C0155) 119. Hyun Ho Park (2018 11). Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells. Korean J Physiol Pharmacol 22(6):679-688. 118. Hyun Ji Ha*, Sunghark Kwon*, Eui Man Jeong*, Chang Min Kim, Ki Baek Lee, In-Gyu Kim, and Hyun Ho Park (2018 10). Crystal structure of G224V mutant form of transglutaminase2 reveals molecular basis of gaining stability and Ca2+-dependent higher activity Plos One 13 (10): e0204707 (NRF-2017M3A9D8062960 and HI17C0155, 2more) 117. Hyun Ji Ha and Hyun Ho Park (2018 10). RAIDD mutations underlie the pathogenesis of thin lissencephaly (TLIS). Plos One 13 (10): e020542 (NRF-2017M3A9D8062960, NRF2018R1A2B2003635, and HI17C0155) 116. Seong-Ah Shin, Sun Young Moon, Woe-Yeon Kim, Hyun Ho Park*, and Chang Sup Lee*(2018). Structure-based classification and anti-cancer effects of plant metabolites. International Journal of Molecular Science 19: 2651*co-corresponding author 115. Hyun Ho Park (2018). Structure of TRAF family: current understanding of receptor recognition. Frontiers in Immunology 9: 1999 (NRF-2017M3A9D8062960, NRF2018R1A2B2003635 and HI17C0155)
114. Eijaz Ahmed Bhat, Chang Min Kim, Sunghwan Kim, and Hyun Ho Park (2018). Inhibitory mechanism of TRIP on the function of TRAF2 revealed by characterization of interaction domains. International Journal of Molecular Science 19: 2457 (NRF-2017M3A9D8062960, NRF2018R1A2B2003635 and HI17C0155) 113. Young-Cheul Shin, Hyungdon Yun, and Hyun Ho Park (2018). Structural dynamics of the transaminase active site revealed by the crystal structure of a co-factor free omega-transaminase from Vibrio fluvialis JS17. Scientific Reports 8: 11454 (NRF-2017M3A9D8062960 and HI17C0155) 112. Chang Woo Lee, Sun-Ha Park, Sung Gu Lee, Hyun Ho Park, Hak Jun Kim, HaJeung Park, Hyun Park, and Jun Hyuck Lee (2018). Crystal structure of dihydrodipicolinate reductase (PaDHDPR) from Paenisporosarcina sp. TG-14: structural basis for NADPH preference as a cofactor. Scientific Reports 8:7936
2017 111. Chang Min Kim, Sun Hee Jeon, Jun-Hyuk Choi, Jun Hyuck Lee, and Hyun Ho Park (2017 12). Interaction mode of CIDE family proteins in fly: DREP1 and DREP3 acidic surfaces interact with DREP2 and DREP4 basic surfaces. Plos One 12 (12): e0189819 (YU 2015) 110. Chang Min Kim, Young-Jin Son, Sunghwan Kim, Seo Yun Kim, and Hyun Ho Park (2017 11). Molecular basis for unique specificity of human TRAF4 for platelet receptors GPIbβ and GPVI. PNAS 114 (43): 11422-11427 (NRF-2017M3A9D8062960) (HI13C1449) 109. Jin Hee Park, Jae Young Choi, and Hyun Ho Park (2017 10). In vitro reconstitution of interactions in the CARD9 signalosome. Molecular Medicine Reports. 16(4): 3910-3916 (Yeungnam University 2014) 108. Hyun Ji Ha and Hyun Ho Park (2017 09). Molecular basis for the effect of the L31F mutation on CARD function in ARC. Febs letters. 590(18): 2919-2928 (NRF2015R1D1A1A01057591) (HI13C1449) 107. Chang Sup Lee and Hyun Ho Park (2017 09). Structural aspects of transglutaminase 2: Functional, structural, and regulatory diversity Apoptosis. 22(9): 1057-1068 (Yeungnam University 2015) 106. Hyun Ho Park (2017 08 01). Filament-like DREP4 CIDE domain: characterization and preliminary X-ray crystallographic studies Acta Crystallograph Sect F Struct Biol Cryst Commun. F73: 481-485 (NRF-2015R1D1A1A01057591) 105. Jae Young Choi, Qi Qiao, Se-Hoon Hong, Chang Min Kim, Jae-Hee Jeong, Yeon-Gil Kim, Yong-Keun Jung, Hao Wu, and Hyun Ho Park (2017 07). CIDE domains form functionally important higher-order assemblies for DNA fragmentation. PNAS 114 (28): 7361-7366 (NRF2015R1D1A1A01057591) (HI13C1449) 104. Chang Woo Lee, Sun-Ha Park, Sung Gu Lee, Seung Chul Shin, Han-Woo Kim, Hyun Ho Park, Sunghwan Kim, Hak Jun Kim, Hyun Park, HaJeung Park, and Jun Hyuck Lee (2017 06). Crystal structure of the inactive state of the receiver domain of Spo0A from Paenisporosarcina sp. TG-14, a psychrophilic bacterium isolated from an Antarctic glacier Journal of Microbiology 55 (6): 464-474 103. Sung Hoon Sim, Soyeon Kim, Tae Min Kim, Yoon Kyung Jeon, Soo Jeong Nam, Yong-Oon Ahn, Bhumsuk Keam, Hyun Ho Park, Dong-Wan Kim, Chul Woo Kim, and Dae Seog Heo (2017
05) Novel JAK3-Activating Mutations in Extranodal NK/T-Cell Lymphoma, Nasal Type, American Journal of Pathology 187 (5): 980-986 102. Chang Min Kim, Jae-Hee Jeong, Young-Jin Son, Jun-Hyuk Choi, Sunghwan Kim, and Hyun Ho Park (2017 03). Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex Febs letter 591 (5): 810-821 (NRF-2015R1D1A1A01057591) (HI13C1449) 101. Seung Un Seo, Hyuk Ki Cho, Kyoung-jin Min, Seon Min Woo, Shin Kim, Jong-Wook Park, Sang Hyun Kim, Yung Hyun Choi, Young Sam Keum, Jin Won Hyun, Hyun Ho Park, Sang-Han Lee, Dong Eun Kim, and Taeg Kyu Kwon (2017 02). Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through down-regulation of c-FLIP and Mcl-1 expression. Cell Death and Disease 8:e2599 100. Jae Young Choi, Tae-ho Jang and Hyun Ho Park (2017 01). The mechanism of folding robustness revealed by the crystal structure of extra-superfolder GFP. Febs letter 591: 442-447 (Yeungnam University 2014)
2016 99. Hye Eun Lee, Gabsik Yang, Nam Doo Kim, Seongkeun Jeong, Yunjin Jung, Jae Young Choi, Hyun Ho Park, and Joo Young Lee (2016 12 29). Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout. Scientific reports 6: 38622 98. Eun Kyung Seo, Jae Young Choi and Hyun Ho Park (2016 08 22). Crystal structure of SYCP1 coiled-coil domain reveals anti-parallel dimeric structure of transverse filament at the syneptonemal complex Plos One 11 (8): e0161379 (HI13C1449) and Yeungnam University 2014. 97. Tae-ho Jang, In-Hye Lim, Chang Min Kim, Jae Young Choi, Eun-Ae Kim, Tae-jin Lee and Hyun Ho Park (2016 08 09). Rescuing neuronal cell death by RAIDD and PIDD derived peptides and its implication of therapeutic intervention for neurodegenerative diseases. Scientific reports 6: 31198 (HI13C1449) and (2014R1 for TJ) 96. Chang Min Kim, Tae-ho Jang and Hyun Ho Park (2016 06 30). Functional analysis of CP2like domain and SAM-like domain in TFCP2L1, novel pluripotency factor of embryonic stem cells. Appl Biochem Biotechnol. 179: 650-658. (HI13C1449) 95. Sam Mathew, Chang Min Kim, Taewan Chung, Hyun Ho Park and Hyungdon Yun (2016 06). Biochemical characterization and crystal structure of thermostable ω-transaminase from Sphaerobacter thermophilus. Enzyme and Microbial Technology 87: 52-60 94. Chang Min Kim, Jae Young Choi, Eijaz Ahmed Bhat, Jee-Hee Jeong, Young-Jin Son, Sunghwan Kim and Hyun Ho Park (2016 05). Crystal structure of TRAF1 TRAF domain and its implications in the TRAF1-mediated intracellular signaling pathway. Scientific Reports 6: 25526 (NRF-2015R1D1A1A01057591) (HI13C1449) 93. Young-Cheul Shin, Chang Min Kim, Jae Young Choi, Ju-Hong Jeon and Hyun Ho Park (2016 04). Occupation of nucleotide in the binding pocket is critical to the stability of Rab11A. Protein Expr. Purif. 120: 153-159. (NRF-2015R1D1A1A01057591) (HI13C1449) 92. Jae Young Choi, Young Chul Shin, Jong Hwan Yoon, Chang Min Kim, Jun Hyuck, Lee, JuHong Jeon, and Hyun Ho Park (2016 03). Molecular mechanism of constitutively active Rab11A was revealed by crystal structure of Rab11A S20V Febs Letter 590: 819-827 (NRF2015R1D1A1A01057591) (HI13C1449)
91. Tae-Ho Jang, Kannan Badri Narayanan and Hyun Ho Park (2016 01). In Vitro Reconstitution of the Toll/Interleukin-1 Receptor (TIR) Domain Complex Between TLR5/6 and MyD88. Protein and Peptide letters. 23: 55-62. (YU2014)
2015 90. Kannan Badri Narayanan, Hyun Ho Park*, and Sung Soo Han* (2015 12). Synthesis and characterization of biomatrixed-gold nanoparticles by the mushroom Flammulina velutipes and its heterogeneous catalytic potential Chemosphere. 141: 169-175 *Co-Corresponding authors 89. Chang Min Kim, Jae Young Choi, Jong Hwan Yoon and Hyun Ho Park (2015 10). X-ray crystallographic analysis of human RAB11(S20V)_constitutively active GTP binding form. Acta Crystallograph Sect F Struct Biol Cryst Commun. 71: 1247-1250 (HI13C1449) 88. Hyun Ho Park (2015 09 01). X-ray crystallographic studies of the middle part of the human synaptonemal complex protein 1 coiled-coil domain. Acta Crystallograph Sect F Struct Biol Cryst Commun. 71: 1131-1134 (HI13C1449) 87. Chang Woo Lee, Jung Eun Kim, Hackwon Do, Ryeo-Ok Kim, Sung Gu Lee, Hyun Ho Park, Jeong Ho Chang, Joung Han Yim, Hyun Park, Il-Chan Kim, and Jun Hyuck Lee (2015 09). Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin Biochem. Biophys. Res. Commun. 465: 12-18 86. Kannan Badri Narayanan and Hyun Ho Park (2015 07 06). Homogeneous catalytic activity of gold nanoparticles synthesized using turnip (Brassica rapa L.) leaf extract in the reductive degradation of cationic azo dye. The Korean Journal of Chemical Engineering. 32(7): 12731277. (HI13C1449) 85. William H. Goodson III et al, Hyun Ho Park and more (2015 06 23). Assessing the carcinogenic potential of low dose exposures to chemical mixtures in the environment: The challenge ahead. Carcinogenesis. 36: S254-S296 84. Kannan Badri Narayanan et al and Hyun Ho Park (2015 06 23). Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis. 36: S89-S110 83. Tae-ho Jang, Seong Hyun Kim, Jae-Hee Jeong, Sunghwan Kim, Yeun Gil Kim and Hyun Ho Park (2015 06 03). Crystal structure of CARD domain of Apoptosis Repressor with CARD (ARC) and its implications in inhibition of apoptosis. Scientific reports 5:9847. (NRF2012R1A2A2A01010870) (HI13C1449), (2014R1A1A1003451 SH) 82. Jae Young Choi, Chang Min Kim, Eun Kyung Seo, Eijaz Ahmed Bhat, Tae-Ho Jang, Jun Hyuck Lee and Hyun Ho Park (2015 05 04). Crystal structure of human POP1 and its distinct structural feature for PYD domain Biochem. Biophys. Res. Commun. 460: 957-963 (HI13C1449) 81. Pradeepraj Durairaj, Sailesh Malla, Saravanan Prabhu Nadarajan, Pyung-Gang Lee, Eunok Jung, Hyun Ho Park, Byung-gee Kim, Hyungdon Yun (2015 04 02). Fungal cytochrome P450 monooxygenases of Fusarium oxysporum for the synthesis of ω-hydroxy fatty acids in engineered Saccharomyces cerevisiae. Macrobial Cell Factories 14: 45. 80. Kannan Badri Narayanan and Hyun Ho Park (2015 03 20). Purification and analysis of the interactions of caspases-1 and ASC for assembly of the inflammasome Appl Biochem Biotechnol. 175: 2883-2894. (NRF-2012R1A2A2A01010870) (HI13C1449)
79. Hackwon Do, Soo Jin Kim, Chang Woo Lee, Han-Woo Kim, Hyun Ho Park, Ho Min Kim, Hyun Park, HaJeung Park, and Jun Hyuck Lee (2015 02). Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes. Scientific reports 5:8196. 78. Sung-Yup Cho, Jin-Haeng Lee, Mi-kyeong Ju, Eui Man Jeong, Hyo-Jun Kim, Jisun Lim, Seungun Lee, Nam-Hyuk Cho, Hyun Ho Park, Kihang Choi, Ju-Hong Jeon, Ingyu Kim (2015 03 04). Cystamine induces AIF-mediated apoptosis through glutathione depletion. BBA - Molecular Cell Research 1853: 619-631 77. Pradeepraj Durairaj, Eunok Jung, Mi-kyeong, Hyun Ho Park, Byung-gee Kim, Hyungdon Yun (2015 03 02). Comparative functional characterization of a novel benzoate hydroxylase cytochrome P450 of Fusarium oxysporum. Enzyme and Microbial Technology 70: 58-65. 76. Hyun Ho Park (2015 02). The domains of apoptosis and inflammation Apoptosis 20: 123. 75. Hyun Ho Park (2015 02). Structural insight of CIDE domain in apoptosis and energy metabolism: The Janus faces of CIDE. Apoptosis 20: 240-249. (HI13C1449) 74. Kannan Badri Narayanan and Hyun Ho Park (2015 02). Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways. Apoptosis 20: 196-209 (NRF2012R1A2A2A01010870) 73. Seung Hyun Kim and Hyun Ho Park (2015 01 02). Expression, crystallization and preliminary X-ray crystallographic studies of CARD domain of ARC. Acta Crystallograph Sect F Struct Biol Cryst Commun. 71: 82-85 (NRF-2012R1A2A2A01010870) (HI13C1449)
2014 72. Tae-Ho Jang, Ju-Hong Jeon, Dong-Sup Lee, Kihang Choi, In-Gyu Kim, Young Whan Kim, and Hyun Ho Park (2014 11 05). Crystal structure of transglutaminase2 with GTP complex and evidence of evolution of GTP binding site. Plos One 9 (9): e107005 (A100190) 71. Seung Mi Lee and Hyun Ho Park (2014. 10. 01). Crystallization and preliminary X-ray crystallographic studies of CIDE domain of Drep2 Acta Crystallograph Sect F Struct Biol Cryst Commun 70: 1414-1417 (YU2012) 70. Kannan Badri Narayanan and Hyun Ho Park (2014. 10 15). Colarimetric detection of manganese (II) ions using gold/dopa nanoparticles. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 131: 132-137 (YU2012 Post-Doc) 69. Kannan Badri Narayanan and Hyun Ho Park (2014 10 01). Antifungal activity of silver nanoparticles synthesized using turnip leaf extract against wood rotting pathogens. European Journal of Plant Pathology 140: 185-192 68. Tae-ho Jang and Hyun Ho Park (2014. 09 23). Crystal structure of TIR domain of TLR6 reveals novel dimeric interface of TIR-TIR interaction for Toll-like receptor signaling pathway. J. Mol. Biol. 426 (19): 3305-3313 (NRF-2012R1A2A2A01010870) (HI13C1449) 67. Kannan Badri Narayanan and Hyun Ho Park (2014. 08 31). Unnatural amino acid-mediated synthesis of silver nanoparticles and their antifungal activity against planktonic and biofilms of Candida albicans and Candida dubliniensis. J of Nanoparticle Research 16: 2523 (2013009083)
66. Tae-ho Jang, Chao Zheng, Jixi Li, Claire Richards, Tom Waltz, Hao Wu and Hyun Ho Park (2014.08 26). Structural study of RIPoptosome core part reveals helical assembly for kinase recruitment. Biochemistry 53 (33): 5424-5431 (NRF-2012R1A2A2A01010870) (HI13C1449) 65. Tae-ho Jang and Hyun Ho Park (2014. 08 01). Preliminary X-ray crystallographic studies of human Toll-like receptor6. Acta Crystallograph Sect F Struct Biol Cryst Commun. 70: 10531055 (NRF-2012R1A2A2A01010870) (HI13C1449) 64. Kannan Badri Narayanan, Tae-Ho Jang and Hyun Ho Park (2014 04). Self-oligomerization of ASC PYD domain prevents the assembly of inflammasome in vitro. Appl Biochem Biotechnol. 172: 3902-3912 (2013009083)(HI13C1449) 63. Tae-ho Jang and Hyun Ho Park (2014 04). Crystallization and preliminary X-ray crystallographic studies of transglutaminase2 in complex with Ca2+. Acta Crystallograph Sect F Struct Biol Cryst Commun. 70: 513-516 (A100190) 62. Jung Nyeo Chun, Sang-Yeob Kim, Eun-Jung Park, Eun Jung Kwon, Dong-Jun Bae, In-San Kim, Hye Kyung Kim, Jong Kwan Park, Lee Sung Won, Hyun Ho Park, Insuk So and Ju-Hong Jeon (2014). Schisandrin B suppresses TGFbeta1-induced stress fiber formation by inhibiting myosin light chain phosphorylation. Journal of Ethnopharmacology. 152(2): 364-371 61. Seung Mi Lee and Hyun Ho Park (2014 03). In vitro analysis of the complete interactions of the Drep system in fly. Apoptosis 19 (3): 428-435 (2011-0025697 and 2013009083) 60. Jong Hwan Yoon, Young-jin Cho and Hyun Ho Park (2014 01). Crystal structure of TRAF4 TRAF domain with coiled-coil domain and its implications in TRAF4 signaling pathway. Acta Crystallograph Sect D Biological Crystallography 70: 2-10 (2013009083)
2013 59. Tae-ho Jang, Jin Hee Park, and Hyun Ho Park (2013). Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. Plos one 8 (11): e79778 (2013009083) 58. Kannan Badri Narayanan and Hyun Ho Park (2013). Pleiotropic functions of antioxidant nanoparticles for longevity and medicine. Advances in colloid and interface science 201-202: 30-42 (2012-010870) 57. Eun Kyung Seo, Tae Woo Kim and Hyun Ho Park (2013). Expression, crystallization and preliminary X-ray crystallographic studies of SCP3 coiled-coil domain. Acta Crystallograph Sect F Struct Biol Cryst Commun. 69: 1281-1283 (2013009083) 56.Seung Mi Lee and Hyun Ho Park (2013). Crystallization and preliminary X-ray crystallographic studies of CIDE-N domain of CIDE-3. Acta Crystallograph Sect F Struct Biol Cryst Commun. 69: 1260-1263 (2013-009083 and 2012-0007386). 55. Seung Mi Lee, Tae-ho Jang and Hyun Ho Park (2013). Molecular basis of homo-dimerization of CIDE domain was revealed by the crystal structure of CIDE-N domain of FSP27. Biochem. Biophys. Res. Commun. 439: 564-569 (2013009083) 54. Kannan Badri Narayanan, Hyun Ho Park*, and Natarajan Sakthivel* (2013). Extracellular synthesis of mycogenic silver nanoparticles by cylindrocladium floridanum and its homogenous catalytic degradation of 4-nitrophenol. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 116: 485-490
53. Tae-Ho Jang and Hyun Ho Park (2013). PIDD mediates and stabilized the interaction between RAIDD and caspase-2 for the PIDDosome assembly. BMB rep. 46: 471-476 (2012010870) 52. Jong Hwan Yoon and Hyun Ho Park (2013). Crystallization and preliminary X-ray crystallographic studies of the TRAF domain of human TRAF4. Acta Crystallograph Sect F Struct Biol Cryst Commun. 69: 1026-1028. (2013-009083) 51. Jong Hwan Yoon and Hyun Ho Park (2013). Preliminary X-ray crystallographic studies of the short form of human TRAF4 TRAF domain. Acta Crystallograph Sect F Struct Biol Cryst Commun. 69: 916-919. (2013-009083) 50. Hyun Ho Park (2013). Structural basis of membrane trafficking by Rab small G proteins. Int J Mol Sci 14: 8912-8923 (2012-010870) (14422-0067 2.598) 49. Tae-Ho Jang*, En Kyung Seo*, and Hyun Ho Park (2013). Analysis of mutation effects on PIDDosome core complex. Appl Biochem Biotechnol. 170: 210-218 (2012-010870) 48. Jin Hee Park*, Ju Young Bae*, and Hyun Ho Park (2013). Self-oligomerization of CARD domain prevents complex formation in the CARMA1 signalosome. Int. J. Mol. Med. 31: 12801287 (2012-010870) 47. Ok Kyeung Park and Hyun Ho Park (2013). A putative role of Drep1 in apoptotic DNA fragmentation system in fly is mediated by direct interaction with Drep2 and Drep4. Apoptosis 18 (4): 385-392 (2011-0025697, 2012-010870, and A100190) 46. Young-Cheul Shin, Eun Kyung Seo, Ju-Hong Jeon and Hyun Ho Park (2013). Crystallization and preliminary X-ray crystallographic studies of the coiled-coil domain of PIST. Acta Crystallograph Sect F Struct Biol Cryst Commun. 69: 468-471. YU2011 45. Jin Hee Park and Hyun Ho Park (2013). Crystallization and preliminary X-ray crystallographic studies of the CARD domain of human CARMA1. Acta Crystallograph Sect F Struct Biol Cryst Commun. 69: 435-437. (2012-010870 and 2011-0025697) 44. Seung Mi Lee and Hyun Ho Park (2013). General interaction mode of CIDE:CIDE domain revealed by a mutation study of the Drep2 CIDE domain. Febs lett. 587: 854-859 (2011-0025697, 2012-010870, and A100190) 43. Kyung Hoon Do and Hyun Ho Park (2013). Crystallization and preliminary X-ray crystallographic studies of cPOP1. Acta Crystallograph Sect F Struct Biol Cryst Commun. 69: 292-294 (A100190 and 2012-010870) 42. Young-Hoon Park, Mi Suk Jeong, Hyun Ho Park, and Se Bok Jang (2013).Formation of the death domain complex between FADD and RIP1 proteins in vitro. Biochim Biophys Acta. 1834: 292-300 (1570-9639 IF : 3.62)
2012 41. Hyun Ho Park (2012). PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway. Apoptosis 17: 1247-1257 (2012-010870) 40. Ok Kyeung Park and Hyun Ho Park (2012). Dual apoptotic DNA fragmentation system in the fly: Drep2 is a novel nuclease of which activity is inhibited by Drep3. Febs Lett. 586: 3085-3089 (2011-0025697 and 2012-010870)
39. Young-Cheul Shin, Tae-Ho Jang, Jong Hwan yoon, Ju-Hong Jeon, and Hyun Ho Park (2012). Crystallization and preliminary X-ray crystallographic studies of Rab6a’(Q72L)-GTP locked form. Acta Crystallograph Sect F Struct Biol Cryst Commun. 68: 1077-1080 (1774-3091 IF : 0.563) YU2010 38. Young-Cheul Shin, Jong Hwan Yoon, Tae-Ho Jang, Seo Yun Kim, Won Do Heo, Insuk So, Ju-Hong Jeon, and Hyun Ho Park (2012). Crystal structure of Rab6a’(Q72L) mutant reveals unexpected GDP/Mg2+ binding with opened GTP-binding domain. Biochem. Biophys. Res. Commun. 424: 269-273 (0006-291X IF : 2.595) (2012-010870 and A100325) 37. Hyun Ho Park (2012). Casein kinase I-like protein linked to lipase in plant. Plant signaling and behavior. 7: 1-3 2011-0025697 36. Hyun Ho Park (2012). Structural features of caspase activating complexes. Int J Mol Sci. 13: 4807-4818 (1422-0067 IF : 2.279) 2011-0003406, 2011-0025697 35. Kyoung Hun Do and Hyun Ho Park (2012). Crystallization and preliminary X-ray crystallographic studies of casein kinase I-like protein from rice. Acta Crystallograph Sect F Struct Biol Cryst Commun. 68: 298-300 (1774-3091 IF : 0.563) A110057 34. Su-Hwa Kim, Eun-Jung Park, Chae Ryun Lee, Jung Nyeo Chun, Nam-Hyuk Cho, In-Gyu Kim, Sanghoon Lee, Tae Woo Kim, Hyun Ho Park, Insuk So, and Ju-Hong Jeon (2012). Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells. Int J Oncol. 40: 1683-1690 (1019-6439 IF: 2.571) 33. Young-il Park, Kyoung Hun Do, In-soo Kim and Hyun Ho Park (2012). Structural and functional studies of casein kinase I-like protein from rice. Plant Cell Physiol. 53(2): 304-311 (0032-0781 IF : 4.257) A100190, 2011-0025697 32. Dongseop Kwon, Jong Hwan Yoon, Soo-Yong Shin, Tae-Ho Jang, Hong-Gee Kim, Insuk So, Ju-Hong Jeon and Hyun Ho Park (2012). A comprehensive manually curated protein-protein interaction database for the Death Domain superfamily. Nucleic Acids Res. 40 (D1): D331-D336 (0305-1048 IF : 7.836) 2011-0003406, 2011-0025697 31. Tae-Ho Jang, Sung-Jun Lee, Chang-Hoon Woo, Kyung Jin Lee, Ju-Hong Jeon, Dong-Sup Lee, Kihang Choi, In-Gyu Kim, Young Whan Kim, Tae-Jin Lee, and Hyun Ho Park (2012). Inhibition of genotoxic stress induced apoptosis by novel TAT-fused peptides targeting PIDDosome. Biochem. Pharmacol. 83 (2): 218-227 (0006-2952 IF: 4.889) A100190
2011 30. Ju Young Bae and Hyun Ho Park (2011). Crystal structure of NALP3 PYD and its implication in inflammasome assembly. J. Biol. Chem. 286 (45): 39528-39536 (0021-9258 IF: 5.328) 20110003406, 2011-0025697 29. Ju Young Bae and Hyun Ho Park (2011). Crystallization and preliminary X-ray crystallographic studies of the PYD domain of human NALP3. Acta Crystallograph Sect F Struct Biol Cryst Commun. F67: 1421-1424 (1774-3091 IF : 0.563) 2011-0003406, 20110025697 28. Dong-Chan Kim, Seoung-Hwan Rho, Jae-Cheon Shin, Hyun Ho Park and Dongjin Kim (2011). Inhibition of melanogenesis by 5,7-dihydroxyflavone (chrysin) via blocking adenylyl cyslase activity. Biochem. Biophys. Res. Commun. 411: 121-125 (0006-291X IF : 2.595) 27. Hyun Ho Park (2011). Structural analyses of death domains and their interactions. Apoptosis 16: 209-220 (1360-8185 IF : 4.397) 2011-0025697 (= 2010-0020962)
26. Ok Kyeung Park and Hyun Ho Park (2011). Crystallization and preliminary X-ray crystallographic studies of the CIDE-domain complex between Drep2 and Drep3 from Drosophila melanogaster. Acta Crystallograph Sect F Struct Biol Cryst Commun. 67: 457-460 (17743091 IF : 0.563) (2010-0020962) 25. Su-Hwa Kim, Hyun Cheol Bae, Eun-Jung Park, Chae Ryun Lee, Byung-Joo Kim, Sanghoon Lee, Hyun Ho Park, Sung-Joon Kim, Insuk So, Tae Woo Kim, and Ju-Hong Jeon (2011). Geranial inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways. Biochem. Biophys. Res. Commun. 407: 129-134 (0006-291X IF : 2.595) 24. Tae-ho Jang, Jin Hee Park, Ju-Hong Jeon, Dong-Sup Lee, Kihang Choi, In-Gyu Kim, Young Whan Kim, and Hyun Ho Park (2011). Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of human ribosomal protein L7a (RPL7a). Acta Crystallograph Sect F Struct Biol Cryst Commun. 67: 510-512 (1774-3091 IF : 0.563) (A100190) 23. Tae-ho Jang and Hyun Ho Park (2011). Generalized semi-refolding methods for purification of the functional death domain superfamily. J Biotechnol. 151: 335-342 (0168-1656 IF : 2.97) (A100325) 22. Su-Hwa Kim, Sung-Young Kim, Eun-Jng Park, Joon Kim, Hyun Ho Park, Insuk So, Seon Jeong Kim, and Ju-Hong Jeon (2011). Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner. Biochem. Biophys. Res. Commun.406 (1): 30-35 (0006-291X IF : 2.595) 21. Bokyung Kim, Ok Kyeung Park, Ju Young Bae, Tae-ho Jang, Jong Whan Yoon, Kyung Hoon Do, Byung-gee Kim, Hyun Don Yun and Hyun Ho Park (2011). Crystallization and preliminary Xray crystallographic studies of beta-transaminase from Mesorhizobium sp. Strain LUK. Acta Crystallograph Sect F Struct Biol Cryst Commun F67: 231-233 (1774-3091 IF : 0.563) YU2009
2010 20. Ju Young Bae and Hyun Ho Park (2010). Purification and characterization of a ubiquitin-like system for autophagosome formation. J Microbial Biotechnol. 20(12): 1647-1652 (1.224) (A084512) 19. Tae-ho Jang, Zheng C, Hao Wu, Ju-hong Jeon, and Hyun Ho Park (2010). In vitro reconstitution of the interactions in the PIDDosome. Apoptosis 15(12): 1444-1452 (1360-8185 IF : 4.397) (2010-0015311) 18. Ji-hoe Kim*, Hyun Ho Park*, Inho Choi, Young Ok Kim, and Kyung-hyun Cho (2010). Severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to hantaan virus infection. BMB rep. 43 (8): 535-540 *equal contribution (1976-6696 IF 2.617) 17. Tae-Ho Jang, Ju Young Bae, Ok Kyoung Park, Ji Hoe Kim, Kyung-hyun Cho, Ju-Hong Jeon and Hyun Ho Park (2010). Identification and analysis of dominant negative mutants of RAIDD and PIDD. Biochim Biophys Acta 1804(7): 1557-1563 (2.773) (1570-9639 IF : 2.773) (20090065643) 16. Tae-ho Jang, Ok Kyeung Park, Bokyung Kim, Ju Young Bae, Byung-Gee Kim, Hyungdon Yun and Hyun Ho Park (2010). Crystallization and preliminary X-ray crystallographic studies of omega-transaminase from Vibrio Fluvialis JS17. Acta Crystallograph Sect F Struct Biol Cryst Commun (1774-3091 IF : 0.563) YU2009
2009 15. Hyun Ho Park (2009). Flexible 50 amino acid residues at the C-termini of DFF45 are critical for its chaperone activity but not for its inhibitory activity against DFF40. BMB rep. 42 (11): 713718 (1976-6696 IF 2.617) 14. Eun-jung Park, Byung-joo Kim, Su-hwa Kim, Sung-Young Kim, Tae-sik Sung, Hong-gu Chae, Sang Jeoung Kim, Jun Kim, Hyun Ho Park, Insuk So, and Ju-hong Jeon (2009). Altered protein integrity of TRPV6 calcium channel by peptide tags. Biol. Pharm. Bull. 32 (10): 1790-1794 (0918-6158 IF : 1.811) 13. Tae-ho Jang and Hyun Ho Park (2009). Purification, crystallization and preliminary X-ray crystallographic studies of RAIDD death domain(DD). Int.J.Mol.Sci. 10: 2501-2509. (1422-0067 IF : 2.279) 12. Hyun Ho Park (2009). The intracellular domain of the p75 low affinity NGF receptor is a death effector domain. Mol. Med. Rep. 2: 539-541 (Cover story). (1791-2997 IF : 0.307) 11. Abhiram Dukkipati, Hyun Ho Park, Deepa Waghray, Suzanne Fisher and K. C. Garcia (2008). BacMam System for High-Level Expression of Recombinant Soluble and Membrane Glycoproteins for Structural Studies. Protein Exp. & Purif. 62: 160-170. (1046-5928 IF:1.644) 10. Hyun Ho Park*, Seong-Hwan Rho*, Young Jun Lim, Min Suk Kang, Byung Kook Lim, Ihn Sik Seong, Chin Ha Chung, Jimin Wang, and Soo Hyun Eom. (2008) Crystal structure of Bacillus Subtilis CodW, a non-canonical HslV-like peptidase with an impaired catalytic apparatus. Proteins 71:1020-1026 *equal contribution (0887-3585 IF : 2.813) 9. Hynu Ho Park, Emmanuelle Logette, Stefan Raunser, Solange Cuenin, Thomas Walz, Jurg Tschopp, and Hao Wu. (2007). Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex. Cell 128:533-546 (0092-8674 IF : 32.401) 8. Hyun Ho Park, Yu-Chih Lo, Su-Chang Lin, Liwei Wang, Jin Kuk Yang and Hao Wu. (2007). The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation. Annu. Rev. Immunol. 25: 561-586 (0732-0582 IF : 49.271) 7. Hyun Ho Park and Hao Wu (2007). Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. Acta Crystallograph Sect F Struct Biol Cryst Commun 63, 229-232 (0.563) (1774-3091 IF : 0.563) 6. Hyun Ho Park and Hao Wu (2006). Crystal Structure of RAIDD Death Domain Implicates Potential Mechanism of PIDDosome Assembly. J. Mol. Biol., 357: 358-64. (0022-2836 IF :4.008) 5. Hyun Ho Park, Hans Tookes, and Hao Wu. (2006). Crystallization and preliminary X-ray crystallographic studies of Drep-3, a DFF-related protein from Drosophila melanogaster. Acta Crystallograph Sect F Struct Biol Cryst Commun 62, 597-599. (1774-3091 IF : 0.563) 4. Qian Yin, Hyun Ho Park, Jee Y. Chung, Su-Chang Lin, Yu-Chih Lo, Li S. da Graca, Xuejun Jiang, and Hao Wu (2006). Caspase-9 Holoenzyme Is a Specific and Optimal Procaspase-3 Processing Machine. Mol Cell, 22: 259-268. (1097-2765 IF : 14.194) 3. Wang J., Rho S.H., Hyun Ho Park, and Eom S.H. (2005). Correction of X-ray intensities from an HslV-HslU co-crystal containing lattice-translocation defects. Acta Crystallogr D Biol Crystallogr. Jul;61(Pt 7):932-41 (0907-4449 IF : 6.326)
2. Dzivenu, O. K., Hyun Ho Park and Hao Wu. (2004). General co-expression vectors for the overexpression of heterodimeric protein complexes in Escherichia coli. Protein Exp. & Purif. 38: 1-8. (1046-5928 IF:1.644) 1. Hyun Ho Park and Hao Wu (2004). Gauging length: recognition of small interfering RNAs. Structure 12: 172-173. (0969-2126 IF:6.337)
E.
Patents
15. TRAF4 결합 모티프를 이용한 혈전증 또는 암질환 치료용 약학조성물 (10-2017-0112535) (NRF-2017M3A9D8062960 and HI13C1449) (출원일: 2017 09 04) 14. TRAF4 결합 모티프를 이용한 혈전증 또는 암 치료제 스크리닝 방법 10-2017-0060430 (HI13C1449 10%) and (NRF-2015R1D1A1A01057591 90%) (출원일: 2017 05 16) 13. Osm1 단백질의 3 차 구조 결정 및 이를 이용한 약물 스크리닝 방법 10-2016-0147951 (NRF2014R1A1A1003451 KSH) and (NRF-2015R1D1A1A01057591) (출원일: 2016 11 08) 12. TRAF1 TRAF 도메인의 3 차구조 결정 및 이를 이용한 약물 스크리닝 방법 10-2016-0031532 (HI13C14490000) (특허등록됨) 11. ARC CARD 도메인의 3 차구조 및 이를 이용한 약물 스크리닝 방법 10-2015-0011185 (101702383) (2017 년 1 월 26 일 등록) NRF-2012R1A2A2A01010870, HI13C1449 10. L-Dopa 를 이용한 one-pot 금나노입자 제조방법과 그것의 Mn 특이적 검출에의 활용 101553471 (10-1553471) (2015 0909 등록) 9. RIP1 DD 및 FADD DD 간 복합체의 ３차 구조 및 이를 이용한 약물 스크리닝 방법(10-20140046684) (NRF-2012R1A2A2A01010870, HI13C14490000) (10-1574424) (2015 1127 등록) 8. TLR6 TIR 도메인의 ３차 구조 및 이를 이용한 약물 스크리닝 방법(10-2014-0046683) (NRF2012R1A2A2A01010870, HI13C14490000) (10-1566107) (20151029 등록) 7. 순무청을 이용한 은나노입자의 친환경적인 제조방법 (10-2013-0107464) (2014 1023 등록) (101456390) 6. TRAF4 TRAF 도메인의 3 차구조 및 이를 이용한 약물 스크리닝 방법 (10-2013-007163) (2015 0730 등록) (10-1542301) 5. 팽이버섯을 이용한 금나노입자의 제조방법(10-2013-0013064) (2012-010870) (2015 0428 등록) (10-1517665) 4. 데쓰 도메인 수퍼패밀리 단백질의 정제 방법 (10-2011-0048556) (10-1262505) (A100325) (2013 0502 등록) 3. NALP3 PYD 의 3 차원 결정 구조 및 이를 이용한 약물 스크리닝 방법(10-2011-00046333) (101304720) (2010-0020962) (2013 0830 등록)
2. 세포사멸 억제용 융합단백질 (10-2010-0104576) (10-1237135) (A084512 and 2010-0015311) (2013 0219 등록) 1. 우성음성 돌연변이 단백질 R147E 및 Y814A, 및 이들의 의학적 용도 (10-2009-0085900) (101170215) (A084512) (2012 0725) 등록