Arthritis Res Ther. 2003; 5(3): 120–130.
PMCID: PMC165040
Published online 2003 Mar 11. doi: 10.1186/ar629
Degeneration of the intervertebral disc Jill PG Urban 1 and Sally Roberts 2 1 University Laboratory of Physiology, Oxford University, Oxford, UK 2 Centre for Spinal Studies, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, and Keele University, Keele, UK Corresponding author. Jill PG Urban:
[email protected]. Received 2003 Jan 6; Accepted 2003 Jan 21. Copyright © 2003 BioMed Central Ltd This article has been cited by other articles in PMC.
Abstract
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Introduction
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Disc morphology
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The normal disc
Degenerated discs
Biochemistry
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Normal discs
Changes in disc biochemistry with degeneration
Effect of degenerative changes on disc function and pathology
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Disc herniation
Aetiology of disc degeneration
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Nutritional pathways to disc degeneration
Mechanical load and injury
Genetic factors in disc degeneration
New therapies
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Cell based therapies
Conclusion
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Competing interests
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Abbreviations
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Acknowledgement
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References
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