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ELSA (Ethical, Legal Social Aspects). - Environmental & Human Safety (EHS). - Outreach & Education. Overall, thi

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Demo Application

Editor’s Note Nano Clusters Definitions

FP-6 • • • • • • • • •

Agrifood CSA Electronics & ICT Environment & Energy Industrial Applications Nanomaterials NanoMedicine Research on Societal Issues Security

FP-7 • • • • • • • • • •

Agrifood CSA Electronics & ICT Environment & Energy Industrial Applications Nanomaterials NanoMedicine Research on Societal Issues Security Textile

Application Instructions: Click on a Category to see the map Click on a sub-category, Acronym or Entity to see detailed description Click the Home button to get back to this page Click on the Back button to return to the map view

Demo Application

Editor’s Note "Nanotechnology" is the brand new frontier of technology in Europe and in the world. It defines the development and application of materials and processes at the nanoscale – the scale of individual molecules. Prominent voices around the world praise the value that they would bring to society and economy, insisting that the value creation process starts from research and continues with the establishment of exploitable portfolio of technologies which would drive numerous applications in manufacturing, energy, environment, healthcare, transport, electronics, etc. This will ultimately turn them into marketable high added value products, market share and profitable revenue streams. Therefore, as nanotechnology is mainly projected in the future, as just a few applications have reached the market, is a critical moment for communication on nanotechnology research. Here in the EU research on nanotechnology takes a very special place, to the extent that information, communication and fostering societal debate on nanotechnology research have already become an essential part of many European policy initiatives. So it is clear that (i) communication on nanotechnology research is critical for Europe and particularly European institutions; as a consequence (ii) selecting and structuring the relevant information to reach key audiences is essential; finally (iii) setting up appropriate methodologies to display this information on nanotechnology research is the ultimate step. This overall exercise has allowed identifying how information on EC funded nanotechnology research can and should be effectively collected, structured and presented to be further communicated to relevant EU audiences. Overall, about two hundreds projects funded under FP6 and FP7 on nanotechnology have been clustered and mapped on the basis of the EC study "Clustering, Mapping and Assessing Nanotechnology Research" (available for internal EC use), conceptually referring to scientific projects and projects supporting policy-making. These two initial groups have been further divided into clusters, some of them sub-divided in sub-clusters. Overall, the following groupings have been identified.

Editor’s Note Scientific projects are grouped in the following clusters reflecting the main field of their research application: -

Nanomedicine (divided in sub-clusters Diagnosis, Drug Delivery and Regenerative Medicine) Energy & Environment Electronics & Information & Communication Technologies(ICT) Agro-food Industrial Applications Nanomaterials Textiles Security

Projects supporting policy-making are grouped in the following clusters reflecting the main field of their research application: - Coordination & Support Actions (i.e. CSA, divided in subclusters Policy Support and Dissemination) - ELSA (Ethical, Legal Social Aspects) - Environmental & Human Safety (EHS) - Outreach & Education

Overall, this tool addresses the challenge of structuring and mapping EC funded projects along three main outlines. First, it shows to what extent the European Commission is contributing to nanotechnology research and development. Secondly, it carries out an original method that clusters and maps EC-funded research, identifying its main benefits for research, industry and society. Finally, it shows the extent the Commission could communicate effectively research results on nanotechnology, designing a dedicated communication database that outlines their potential impacts to science, innovation, society and media. In this light, this tool is a true “first” for EC-funded nanotechnology research: we do hope to have contributed well enough to fulfil all these challenges, so to inspire others. M atteo Bonazzi P rogram m e Officer in converging technologies Unit N ano- and Converging Sciences and Technologies Directorate Industrial Technologies, DG R esearch of the European Com m ission

NANO CLUSTERS DEFINITIONS Agrifood - Nanotechnology has a significant potential impact on farming, food and the bioenergy production chain.

However, many health and safety concerns are being raised, especially as far as the scenario of humans and livestock ingesting manufactured nanoparticles is involved. The agrifood sector promises to create nano bio-industrial products, from nano-sensors that can measure water stress and plant diseases to those that can reduce the amount of fertilizers and pesticides used on crops, all the way to detecting bacterial pathogen contamination during food processing and post-harvest.

CSA’s - This cluster includes EC actions aimed at coordinating nanotechnology research activities and policies, and

those aimed at contributing to the implementation of the Framework Programmes and the preparation of future policies. Participation of SMEs, civil society organizations and scientific networks of excellence are considered pivotal. The strategic objectives are about sharing and generating new knowledge in the nanotechnology field and to promote innovation that will enable the manufacturing of new high value, competitive products.

Diagnostics - This is the first step on the way to personalized medicine. Nanotechnology is going to usher in a

revolutionary era in medical imaging, by pinpointing diseases with greater accuracy than ever before. Cancers could be accurately detected at the earliest possible stage and non-invasively, while a new nano-labeling system could flag them up throughout the body. Of course, the new imaging techniques will greatly facilitate surgery. But NT is also focusing heavily on the early detection of genetic and degenerative diseases

NANO CLUSTERS DEFINITIONS Drug Delivery - Localized delivery is the key challenge to tailor individual therapies down to the very molecules

that need targeting. The goal is the ability to selectively attack the diseased cells, while saving healthy organs or tissues from the heavy collateral damage caused by non-specific drug toxicity. A whole range of different nano-vectors for drug encapsulation, guiding techniques to latch them onto their target and multifunctional nanotherapeutics are being developed. Eventually, NT drug delivery systems could be injectable, oral, implantable or trans-dermal.

EHS - Risk assessment and management of the potential health and safety impacts of NT are the main issues here.

Nano-safety research focuses on understanding the effects of engineered nanomaterials on the human body and the environment. A lot of study is being put into the mechanisms of disaggregation/conglomeration of nanomaterials, the transport mechanisms between material release and actual delivered dosage to human organs, and the effects of prolonged exposure to nanomaterials on the workplace.

Electronics & ICT - Nanotechnology is paving the way to miniaturized supercomputers, the development of

pervasive computing through the so-called "smart dust", ultra-fast semiconductors and microprocessors, not to mention low voltage and high brightness displays. This field would quickly exploit all the potential applications of thin film transistors, molecular electronics and nanolithography. It is clear that NT would enable the industry to produce ever smaller, cheaper, faster products

NANO CLUSTERS DEFINITIONS ELSA - Acceptance of NT developments by the general public after careful consideration of all their ethical, legal and

social aspects is of the essence here. Public perceptions and attitudes need to be understood before the launch of such new technology, especially when people are ambivalent and concerned about whether certain NT developments will be beneficial or potentially hazardous, or about the way society will look after they have become mainstream. Converging NT is an obvious candidate for ethical reflection. NT governance guided by the understanding of ELSA issues is the ultimate goal.

Environment / Energy - Cheap and powerful renewable energy generation and clean water supplies are some

of the main prospected benefits of this cluster. NT is moving closer to developing particle and filter systems that can bind, break down, remove or inactivate pollutants and provide enhanced environmental monitoring. Water filtration, purification and desalination, if achieved on a wide scale, could improve living conditions in developing countries considerably. More efficient solar cells would cut down on emissions and the dependence on fossil fuels.

Industrial Applications - Some of the main production areas involving NT span from ultra-lightweight, highstrength, precision-formed materials to nano-composite polymers for structural and electronic applications; from membranes and filters for cost-effective desalinization of water to thermal and optical barriers; from inkjet materials to high efficiency and novel catalysts. The whole development of nano-sensors for medical diagnosis, environmental monitoring or industrial quality control is a chapter onto itself.

NANO CLUSTERS DEFINITIONS Nanomaterials - Carbon-based nanomaterials (such as fullerenes or nanotubes), metal-based materials (such as

nanogold, nanosilver or titanium oxide), dendrimers (nanoscale polymers built from branched units) and nanocomposites (combining nanoparticles with larger, conventional-scale materials) use the properties of materials at the nanoscale. Self-assembly is a notable set of technologies with the potential to complete the nano revolution, by exploiting the interactions between molecules the way nature does.

Outreach - A whole cluster of original, ground-breaking projects reaching out to a broad variety of key audiences

including young people, journalists, scientists, industry and business, NGOs and policy-makers has been spreading the network of EC nanotechnology communication far and wide. Information about nanotechnology developments and future perspectives is being closely followed by public dialogue and social engagement about nanotechnology acceptance.

Regenerative Medicine - Restoring, maintaining and repairing tissues and organ functions is the new life-saving promise that nanotechnology can propel towards success. This could be achieved by combining living cells with biomaterials acting as scaffolds to support cell proliferation of vital tissue, or by bringing in specific nanoparticles to reproduce the correct signals guiding cells towards a desirable behaviour. Nanopatterning of biomaterial surfaces aimed at eliciting certain biological responses from the host tissue is also a hot topic.

NANO CLUSTERS DEFINITIONS Security - Nanotechnology can give a significant contribution to civil security through novel detection, protection and identification methods. Detection includes selective imaging, eg by using different parts of the electromagnetic spectrum, and biosensor monitoring of bacterial and viral contamination, eg of drinking water supplies. Protection would eventually involve toxin decontamination and filter applications, and also the strengthening of building structures. In the cases of detection and identification, privacy is the main ELSA issue here

Textiles - Whether they are antibacterial, MRSA-resistant bandages for medical applications or stain-resistant

fabrics, nanotechnology textiles are about high performance. Smart nano-fabrics can clean themselves by taking full advantage of the lotus effect, or they could be UV blocking, flame retardant or may never wear out. In any case they are likely to enter the very fabric of our lives, as they could even be used for wireless biomonitoring of vital functions.

ULTRA-1D SURMOF SEMINANO SA-NANO PSY-NANO-SI PECTICOAT NUCAN NANOTEMPLATES NACBO NANOCHEMSENS

VSNS TAMIRUT SNIP2CHIP RECEPTRONICS NEWTON NAS-SAP NABIS GENSENSORNANOPARTS GANANO ACTIVE BIOMICS BIODOAGNOSTICS BIODOT BIOMAGSENSE

FP-7 FP-7 (616) • Agrifood (12) • CSA (50) • Electronics & ICT (34) • Environment & Energy (59) • Industrial Applications (123) • Nanomaterials (40) • NanoMedicine (217) • Research on Societal Issues (169) • Security (8) • Textile (15)

BACWIRE

WOODLIFE SUNPAP SMW SAWHOT ADDNANO EMBEK1 FIBLYS INGENIOUS INNOSHADE MDSPM MULTIPLAT PLASMANICE RESOLVE S3 MAO ROBOTS

3D Nanobiodevice 3Micron Bisines Bond Caminems Monad Mulitplat Nadine Namdiatream Nanodiara Nanosequencing Nanofol Nano-mubiop Nanother SMD Vibrant

3D-NANOBIODEVICE • • •

Acronym: 3D-NANOBIODEVICE Project Title: Three-dimensional nanobiostructure-based self-contained devices for biomedical application Participants:



Project Abstract: The main scientific objective of the project is to enhance the understanding of the fundamental principles for controlling electron transfer reactions between nanoparticles (NPs), carbon nanotubes (CNTs), their assemblies confined into three-dimensional (3D) microscale networks, conductive nano/-microporous silicone (NMPSi) chips and different bioelements, such as glucose oxidising and oxygen reducing enzymes. The technological objective of the project is to construct potentially implantable microscale self-contained wireless biodevices working in different biomatrices, e.g. blood, plasma, saliva. Novel biodevices will be constructed by combination of glucose and oxygen sensitive biosensors powered by biofuel cells, all made from 3D nanobiostructured materials and operated by wireless microtransmitter/transducer system. To produce 3D microscale devices with superior characteristics mathematical modelling of their performance will be compared against experimentally determined parameters. Nanowiring of appropriate redox enzymes with NPs, CNTs, proper surface modifications, and use of Os and Ru redox complexes, are chosen as a major direction to solve main obstacles in the area of bioelectronics, i.e. poor electronic communication between the biocomponents and the electronic elements along with insufficient operational stability. The 3D structure of nanobiodevices will provide very high efficiency and stability along with their miniaturisation for successful application in biomedicine and health care. The developed, wireless self-contained and potentially implantable, 3D nanobiostructure-based devices will be used to improve quality of life and increase safety in case of widely occurring chronic diseases. Moreover, in the long-term, 3D nanobiostructure-based elements will be essential for constructing devices to be used for neuron/nerve stimulations and compensation of human disabilities.

– – – – – – – – – – –

AARHUS UNIVERSITET (AU), www.au.dk , (DK) UNIVERSITAET FUER BODENKULTUR WIEN (BOKU), www.boku.ac.at , (AT) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) MALMOE HOEGSKOLA (MALMOE UNIVERSITY) (Mah), www.mah.se , (SE) NOVOSENSE AB (NS), www.novosense.se , (SE) NATIONAL UNIVERSITY OF IRELAND, GALWAY (NUIG), www.nuigalway.ie , (IE) NOVOZYMES A/S (NZ), www.novozymes.com , (DK) RUHR-UNIVERSITAET BOCHUM (RUB), www.ruhr-uni-bochum.de , (DE) UNIVERSITY OF LIMERICK (UL), www.ul.ie , (IE) LUNDS UNIVERSITET (ULUND), www.lu.se , (SE) UNIVERSITY OF SOUTHAMPTON (US), http://www.southampton.ac.uk , (UK)

3MICRON • • •

Acronym: 3MICRON Project Title: Three modality contrast imaging using multi-functionalized microballoons Participants:



Project Abstract: In vivo multimodality imaging is a fast growing field in medical research and, although the achievements at clinical level of this diagnostic method are recent, it is already one of the most promising approaches in the diagnosis of diseases in many research addressed medical centres. At present in this area, the USA plays the protagonist role as a result of the amount of resources engaged in the arena in the last decade. Both government and private companies agree, when considering the potential of this approach, that it is one of the foremost medical advancements as it will lead to early diagnosis of diseases with high impact on the societies of western countries. Multimodality imaging is currently viewed as a simple and powerful integration of two or more imaging methods (e.g. PET-CT). 3MICRON is an ambitious project which gathers some of the most advanced European medical and technical institutions together to address the design of new strategies in diagnostics, and to push the potential of medical imaging beyond the state-of-the-art. The multimodality approaches are supported by a class of next-generation micro/nanodevices called microballoons. These subsystems are able to implement the function of an ultrasound contrast agent with other imaging methods (SPECT, MRI). In the future, they may act as a minimally invasive drug delivery method and hyperthermia device. In 3MICRON, this multi-functional device will be tested in vitro and in vivo in order to assess bioclearance and cytoxicity effects toward high impact diseases, e.g. cardiovascular and inflammation pathologies. Finally, selected types of microballoons will undergo pre-clinical screening for a consolidated assessment of the “bench-to-bed” pathway for these new microdevices.

– – – – – – – – – –

DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ), www.dkfz.de , (DE) ESAOTE SPA (Esaote), http://www.esaote.com , (IT) FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (INT), www.istitutotumori.mi.it , (IT) KAROLINSKA INSTITUTET (KI), www.ki.se , (SE) KUNGLIGA TEKNISKA HOEGSKOLAN (KTH), www.kth.se , (SE) STIFTELSEN SINTEF (Sintef), www.sintef.no , (NO) Surflay Nanotec GmbH (Surflay), www.surflay.com , (DE) UNIVERSITAET BAYREUTH (UBT), www.uni-bayreuth.de , (DE) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (UCD), www.ucd.ie , (IE) UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA (UNITV), www.uniroma2.it , (IT)

ACTIVE BIOMICS • • •

Acronym: ACTIVE BIOMICS Project Title: Active Biomimetic Systems Participants:



Project Abstract: The STREP proposed here deals with biomimetics at the supramolecular or subcellular level which covers the nano- and microregime. In this regime, biological systems exhibit many active processes which are driven by a variety of biomolecular nanomaschines or motors. The biomimetic systems studied in this STREP contain two types of linear motors, growing filaments and stepping motor proteins. Growing filaments generate pushing forces, stepping motor proteins exert pulling forces. The project has several scientific objectives: to understand the molecular processes which are responsible for the generation of these forces; to elucidate the cooperative behavior of small and large groups of motor molecules which lead to active surface layers and active filament assemblies or scaffolds; and to control and optimize the properties of these biomimetic systems. The research performed in this STREP is at the cutting edge of science and has a high potential for long-term innovation. Indeed, there are many possible applications in bioengineering, pharmocology, and medicine such as sorting devices for biomolecules and biocolloids, active drug delivery systems, and force generating components for the development of nanoscale manufacturing.

– – – – – – – – – – –

STICHTING VOOR FUNDAMENTEEL ONDERZOEK DER MATERIE - FOM (AMOLF), www.fom.nl , (NL) BASF SE (BASF), www.basf.com , (DE) INSTITUT CURIE (CURIE), www.curie.fr , (FR) EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL), www.embl.org , (DE) INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES (ICCAS), www.icas.ac.cn , (CN) LEIBNIZ INSTITUT FUER ALTERS FORSCHUNG - FRITZ LIPMANN INSTITUT E.V. (IMB), www.fli-leibniz.de , (DE) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (LEBS), www.cnrs.fr , (FR) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPI), www.mpg.de , (DE) NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY (NANOCRT), , (CN) POLITECNICO DI MILANO (PMILA), , (IT) UNIVERSITAET LEIPZIG (ULEIP), http://www.uni-leipzig.de , (DE)

ADDNANO • • •

Acronym: ADDNANO Project Title: The development and scale-up of innovative nanotechnology-based processes into the value chain of the lubricants market Participants:



Project Abstract: The objective of the AddNano project is to investigate the prospects for overcoming the many existing technological barriers in the supply and usage chain, towards the establishment of a large scale market introduction of a new generation of fluid lubricants incorporating nanomaterials. The AddNano consortium combines technological expertise and industrial representation from all parts of the prospective value chain to investigate the development of new nano-based lubricants. Fluid lubricants are used in almost every field of human technological activity and their purpose is multifold: they reduce frictional resistance, protect the engine against wear between contacting surfaces, remove wear debris, reduce heating and contribute to cooling, improve fuel economy, improve emissions. Advanced nanomaterials recently developed, such as inorganic fullerene-like materials (IF’s) and others, have shown some initial promise for their contribution to reducing friction and enhancing protection against wear. If able to be developed into full commercial-scale production, if they can be incorporated in a stable fashion into full formulations, and if their performance benefits relative to the best of conventional technologies can be sustained under those circumstances, they offer the prospect for some performance breakthroughs not seen since the development of the now ubiquitous anti-wear additives, Zinc Dialkyl Dithiophosphates (ZDDP’s), around 70 years ago. Within engine oils and other lubricant applications, such as transmission fluids, and for greases used in rotational bearings, the potential exists for lubricants containing nanomaterials to significantly reduce friction and enhance machine durability. This can contribute to substantial energy savings, reduced equipment maintenance and longer machine lifetime.

– – – – – – – – – – – – – – –

BHR GROUP LIMITED (BHR), www.bhrgroup.com , (UK) FUNDACION CIDETEC (CIDETEC), www.cidetec.es , (ES) CENTRO RICERCHE FIAT SCPA (CRF), www.crf.it , (IT) ECOLE CENTRALE DE LYON (Ecole Centrale Lyon), www.ec-lyon.fr , (FR) Infineum UK Ltd (Infineum), www.infineum.com , (UK) INS s.a.r.l. (INS), , (FR) KRAFFT S.L. (KRAFFT S.L.), , (ES) MULTISOL FRANCE (Multisol France), , (FR) UNIVERSITA DEGLI STUDI DI SALERNO (NANO_MATES-UNISAL), www.unisa.it , (IT) NANOMATERIALS LTD (NanoMaterials), www.apnano.com , (IL) Petronas Lubricants Italy (Petronas), www.selenia.com , (IT) POLITECNICO DI TORINO (POLITO), www.polito.it , (IT) RICARDO UK LIMITED (RICARDO), www.ricardo.com , (UK) STOCKHOLMS UNIVERSITET (Stockholms Universit), www.su.se , (SE) WEIZMANN INSTITUTE OF SCIENCE (Weizmann Institute), www.weizmann.ac.il , (IL)

ADONIS • • •

Acronym: ADONIS Project Title: Accurate Diagnosis of prostate cancer using Optoacoustic detection of biologically functionalized gold Nanoparticles- a new Integrated biosensor System Participants: – – – – – –



EL.EN. SPA (ELEN), , (IT) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER / IBMT), www.fraunhofer.de , (DE) INSTITUTE OF CANCER RESEARCH - ROYAL CANCER HOSPITAL (ICR), http://www.icr.ac.uk , (UK) TP21 GMBH (TP21), www.tp21.de , (DE) UNIVERSITAET BERN (UBERN), http://www.unibe.ch , (CH) UNIVERSITE DE LIEGE (ULG), www.ulg.ac.be , (BE)

Project Abstract: Prostate Cancer is the most common cancer disease for men. The choice of treatment and its efficiency relies strongly on the stage in which the cancer is when diagnosed. Screening procedures like digital rectal examination (DRE) and free prostate specific antigene (PSA) level testing are well established but lack accuracy, yielding only 80 % of prostate cancers diagnosed in an early state. The objective of ADONIS is the proof of concept of using optoacoustic imaging in combination with biologically functionalized nanoparticles as an integrated biosensor based system for accurate diagnosis of prostate cancer. The idea behind ADONIS is to combine the superb biosensor selectivity of immunogold labelling with the peculiar optical properties of gold nanoparticles. It was recently shown that gold nanoparticles have very strong surface plasmon absorption of light that is sensitive to their shape and dimensions. The absorption of light from these localized absorption centers generates pressure waves, which propagate through the tissue to be detected and analyzed with techniques similar to conventional ultrasonic imaging. Exploiting this effect in combination with the possibilities of biological targetting of nanoparticles using a tumour marker like prostate specific membrane antigen (PSMA), the expected result is a new concept for biosensor based diagnosis of prostate cancer which will allow the development of overall accessible, cost-efficient medical instruments for accurate diagnosis.

AMBIO • • •

Acronym: AMBIO Project Title: Advanced nanostructured surfaces for the control of biofouling Participants: – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – –

INTERNATIONAL PAINT LIMITED (AKZO NOBEL), , (UK) GLOBAL AQUAFISH S.L. (AQUAFISH), www.globalaquafish.com , (ES) ARGUS CHEMICAL SRL (ARGUS), www.argus.it , (IT) BASF SE (BASF), www.basf.com , (DE) BIOLOCUS A/S (BIOLOCUS), www.biolocus.com , (DK) FUNDACION CIDETEC (CIDETEC), www.cidetec.es , (ES) CENTRUM TECHNIKI OKRETOWEJ SPOLKA AKCYJNA (CTO), www.cto.gda.pl , (PL) GEBZE YUKSEK TEKNOLOJI ENSTITUSU (GYTE-TR), www.gyte.edu.tr , (TR) INSTITUT ZA KOVINSKE MATERIALE IN T EHNOLOGIJE*INSTITUTE OF METALS AND TECHNOLOGY (IMT), www.imt.si , (SI) INSTITUT NATIONAL POLYTECHNIQUE DE LORRAINE (INPL), http://www.inpl-nancy.fr/ , (FR) LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN E.V. (IPF), www.ipfdd.de , (DE) KEMA NEDERLAND BV (KEMA), www.kema.com , (NL) SWEREA KIMAB AB (KIMAB), www.swerea.se , (SE) LAVIOSA CHIMICA MINERARIA SPA (LCM), www.laviosa.it , (IT) LINKOPINGS UNIVERSITET (LIU), www.liu.se , (SE) MARINA PORT ZELANDE BV (MPZ), www.mpz.nl , (NL) NANOCYL S.A. (NANOCYL), www.nanocyl.com , (BE) OCEANOGRAPHIC COMPANY OF THE NETHERLANDS B.V. (OCN), , (NL) POLYMER LABORATORIES LIMITED (POLYMER), www.polymerlabs.com , (UK) SUSTECH GMBH & CO. KG (SUSTECH), www.sustech.de , (DE) TEER COATINGS LIMITED (TCL), www.teercoatings.co.uk , (UK) TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY. (TECHNION), www.technion.ac.il , (IL) NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO (TNO), www.tno.nl , (NL) RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG. (UHEI), www.uni-heidelberg.de , (DE) UNIVERSITE DE MONS-HAINAUT (UMH), www.umh.ac.be , (BE) UNIVERSITY OF NEWCASTLE UPON TYNE (UNEW), www.newcastle.ac.uk , (UK) UNIVERSITA DI PISA (UNIPI), www.unipi.it , (IT) UNIVERSITY OF DUNDEE (UNIVDUN), www.dundee.ac.uk , (UK) THE UNIVERSITY OF BIRMINGHAM (UOB), www.bham.ac.uk , (UK) VAL VGS AS (VAL VGS), www.val.vgs.no , (NO) WALLENIUS MARINE AB* (WM), www.walleniusmarine.com , (SE) ZENON EUROPE TERMELO ES SZOLGALTATO KFT (ZENON), www.zenon.com , (HU)

AMBIO cont. •

Project Abstract: All structures in aquatic environments suffer from aggressive biofouling, which is economically costly, and its control imposes environmental burdens through release of biocides. Current non-biocidal coatings are unsuitable for most applications. Hence there is a 'technology gap' demanding innovation. The biofouling process involves interfacial interactions determined within a few nanomaters of a surface. Control of interfacial phenomena requires, therefore, a capability for molecular level engineering of surfaces. The goal of the AMBIO project is to develop innovative non-biocidal solutions to the problem of aquatic biofouling, using a range of molecular surface engineering approaches. The project integrates industries, universities and research organisations into a coordinated interdisciplinary programme incorporating all the necessary elements from nanomaterials engineering to biological evaluation and end-user trials. The industrial supply chain built into this IP will ensure durable impacts through technology transfer from the programme to industrial production. The project will use a 'knowledge-driven' research approach rather than empirical testing. Novel, nanoscale surfaces will be evaluated by biologists in rapid adhesion assays and characterised physically in terms of molecular orientation, conformation and surface dynamics. The results will be used to modify the models and refine the surfaces in an iterative approach. The most promising strategies will be developed as practical surfaces and subjected to field-testing of prototype products for end-use applications in the areas of hull coatings, membrane filters, aquaculture equipment, instrumentation, water-inlets and heat exchangers. The project will be Europe's first large-scale, multidisciplinary research programme to meet the problem of aquatic biofouling and thus will be a 'flagship' for European non-biocidal R&D.

AMNA • • •



Acronym: AMNA Project Title: Addressable Molecular Node Assembly -a Generic Platform of Nano-scale Functionalised Surfaces Based on a Digitally Addressable Molecular Grid Participants: – – – –

CHALMERS TEKNISKA HOEGSKOLA AB (CHALMERS), www.chalmers.se , (SE) CONSORZIO INTERUNIVERSITARIO PER LO SVILUPPO DEI SISTEMI A GRANDE INTERFASE (CSGI), www.csgi.unifi.it , (IT) UNIVERSITY OF SOUTHAMPTON (SOTON), http://www.southampton.ac.uk , (UK) UNIVERSITE LOUIS PASTEUR (ULP), www-ulp.u-strasbg.fr , (FR)

Project Abstract: The goal is a nano-technology platform based on a 100 nm size grid of addressable molecular building blocks, a novel bottom-up modular approach to place functional groups at defined positions in space with sub-nm precision. An almost complete freedom of choice, for grid assembly as well as for positioning of functional groups is based on a "digital" code for molecular recognition. The project involves very demanding synthetic and physico-chemical tasks: on the other hand, if successful the reward is enormous as it can provide a basis for a range of forceful nanotechnological applications (it might even become the basis for future nanotechnology!). High structural fidelity and convenient assembly rates are achieved using DNA base-pair recognition and stacking into rigid double-helical structures. Each node has typically three oligonucleotide strands and a moiety for attachment of either a functional group or a lipid anchoring group, so that a group of six nodes are connected into a hexagon (energetically favourable) providing a planar network of hexagons. Further kinetic robustness may be achieved. The partners represent the ultimate expertise in Europe in synthetic and supramolecular chemistry and in biophysical, colloidal and photophysical chemistry, needed for the joint venture: 1. Synthetic strategy for node building blocks. 2. Tuning interactions and reaction rates to ascertain correct assembly into grid attached to lipid support. 3. Positioning of functional groups. 4. Analytical tools to follow assembly and verify structures. From here various applied projects will take over, attaching interesting functional groups at pre-determined positions on the grid map, and supramolecular structures extending perpendicular to the grid surface, into the 3rd dimension. The proposal fits well the call, being a novel bottom-up approach to achieve self-organising nanostructures with high resolution and control of properies and performance.

ARTIC • • •

Acronym: ARTIC Project Title: Nature-inspired micro-fluidic manipulation using artificial cilia Participants:



Project Abstract: The ARTIC project deals with an innovative method of fluid manipulation in micro-fluidics systems, inspired by nature,namely by the mechanisms found in ciliates. A cilium can be viewed as a small hair or flexible rod (typical length 10 mm and diameter 0.1 mm) attached to the surface of micro-organisms. The cilia move back and forth collectively in a particular concerted manner, and are in this way quite effective in generating propulsion or flow (order of several mm/s). The overall objective of the ARTIC project is to explore and develop a novel micro-fluidics technology on the basis of polymeric microactuators inspired by the natural ciliates. The preferred method for controlled actuation of artificial cilia arrays is by using a magnetic field and incorporating magnetic nanoparticles in the polymeric cilia. The nature of the manipulation may be quite broad: transportation, mixing, sorting, deforming, or rupturing. Typical sizes of the micro-fluid channel widths and heights range from several to hundreds of micrometers. The ability to manipulate fluids in micro-channels will be essential for the development of future high-tech applications like biosensor devices, micro-channel cooling of electronics, pharmaceutical and chemical high-throughput testing and controlled drug delivery systems. The multidisciplinary character of the project is reflected by the consortium that comprises one large industrial partner, one SME, and six university groups. The industrial partners are in the fields of micro/nanotechnology and medical systems (Philips, NL), and magnetic materials (Liquids Research Ltd., UK). The university groups are world-class in the fields of polymer synthesis and nanostructuring (Freiburg, DE), micro-mechanical modelling (Groningen, NL), electromagnetic modelling and design (Bucharest, RO), biomimetics (Bath, UK), fluid flow measurement (Delft, NL), and fluid-structure interaction modelling (Eindhoven, NL).

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UNIVERSITY OF BATH (CBNT), , (UK) ALBERT-LUDWIGS-UNIVERSITAET FREIBURG (IMTEK), www.uni-freiburg.de , (DE) LIQUIDS RESEARCH LIMITED (LRL), www.liquidsresearch.co.uk , (UK) PHILIPS ELECTRONICS NEDERLAND B.V. (PHILIPS), www.philips.com , (NL) UNIVERSITATEA POLITEHNICA DIN BUCURESTI (PUB), , (RO) RIJKSUNIVERSITEIT GRONINGEN (RUG), www.rug.nl , (NL) TECHNISCHE UNIVERSITEIT EINDHOVEN (TU/E), www.tue.nl , (NL) TECHNISCHE UNIVERSITEIT DELFT (TUD), www.tudelft.nl , (NL)

ASMENA • • •

Acronym: ASMENA Project Title: Functional assays for membrane protein on nanostructured supports Participants:



Project Abstract: More than 50% of all drug targets are membrane proteins; new research tools to screen function of membrane drug targets are therefore expected to open up new avenues for original drug development. The proposed project addresses the need of the pharmaceutical industry for new technologies for reliable and efficient screening of membrane proteins as drug targets. Most critical current aspects of membrane protein assays are (a) the lack of reliable procedures to immobilize membrane proteins on sensor surfaces in a format suitable for label-free high-throughput screening of drug candidates; (b) the need for downscaling assay formats to accelerate functional screening; and (c) the feasibility of reading out the diverse functions of membrane proteins. The partners – with highly complementary expertise and experience of working together – will develop platforms for functional membrane protein assays by integration of the most recently gained knowledge and techniques. The key concepts of the platforms include (a) exploitation of nanoporous substrates to enhance the stability of supported proteolipid membranes and their integration in a sensor chip format; (b) nanoscale surface modifications for directed self-assembly of proteolipid structures on chip; and (c) self-assembly of proteolipid membranes onto nano-sized sensor structures from proteoliposomes, and demonstration of the functionality in quantitative drug candidate screening assays suitable for commercial applications. The project is expected to make a substantial contribution to (a) improved understanding of lipid membrane and membrane protein interaction with designed nanoenvironments; (b) development of prototype products and intellectual property related to membrane protein sorting and handling; (c) new compounds for functionalization of biosensor applications; (d) cost-effective array-based concepts for nanoplasmonic and electrochemical sensing; and (e) functional assays for membrane protein drug targets.

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CHALMERS TEKNISKA HOEGSKOLA AB (Chalmers), www.chalmers.se , (SE) EÖTVÖS LORÁND TUDOMÁNYEGYETEM (ELTE), www.elte.hu , (HU) Eidgenössische Technische Hochschule Zürich (ETH Zurich), www.ethz.ch , (CH) Farfield Group Limited (Farfield), , (UK) HYDROGENE AB (Hydrogene AB), , (SE) Layerlab AB (LayerLab), www.layerlab.se , (SE) LEISTER PROCESS TECHNOLOGIES* (Leister), www.leister.com , (CH) MIKROVAKUUM MIKROELEKTRONIKAI ES VAKUUMTECHNIKAL KFT (MicroVacuum), www.microvacuum.com , (HU) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) PAUL SCHERRER INSTITUT (PSI), www.psi.ch , (CH) F. HOFFMANN-LA ROCHE AG (Roche), www.roche.com , (CH) SuSoS AG (SuSoS), www.susos.com , (CH) UNIVERSITEIT TWENTE (Twente), www.utwente.nl , (NL) UNIVERSITE DE BORDEAUX I (UB1), www.u-bordeaux1.fr , (FR)

ASPRINT • • •

Acronym: ASPRINT Project Title: Advanced Scanning PRobes for Innovative Nanoscience and Technology Participants: – – – – – – – – – – – – –



INSTITUT DE CIENCIES FOTONIQUES, FUNDACIO PRIVADA (ICFO), www.icfo.es , (ES) STICHTING KATHOLIEKE UNIVERSITEIT (KUN), www.ru.nl , (NL) UNIVERSITEIT TWENTE (MESA), www.utwente.nl , (NL) NANOWORLD SERVICES GMBH (NANOWORLD), www.nanoworld.com , (DE) NASCATEC GMBH* (NASCATEC), www.nascatec.com , (DE) OMICRON NANOTECHNOLOGY GMBH (OMICRON), www.omicron.de , (DE) THE PROVOST FELLOWS & SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (TCD), www.tcd.ie , (IE) TECHNISCHE UNIVERSITEIT EINDHOVEN (TU/E), www.tue.nl , (NL) UNIVERSITAET HAMBURG (U HAMBURG), http://www.uni-hamburg.de/ , (DE) UNIVERSITE DE BOURGOGNE (UB), www.u-bourgogne.fr , (FR) UNIVERSITEIT LEIDEN (UL-LION), http://www.leidenuniv.nl , (NL) UNIVERSITAET DES SAARLANDES (USAAR), www.uni-saarland.de , (DE) WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER (WWU), , (DE)

Project Abstract: The objective of this network is to advance and to develop truly novel scanning probe tools that will allow to investigate and manipulate materials properties on a nanometer scale.This includes the development of a new generation of probes and probing concepts, nanostructuring, development of essential spectroscopic methods likespin-polarized tunneling, optical techniques on a nanometer scale as well as the development of new smart nanoprobes like video scanning probe microscopy.This will require considerable developments both in experimental approaches and techniques, materials and theoretical understanding. To this end the consortium will combine the existing European expertise in this field, combining research laboratories and commercial enterprises and acting as a center of knowledge.

BACTERIOSAFE • • •

Acronym: BACTERIOSAFE Project Title: Active wound dressings based on biological mimicry Participants:



Project Abstract: The aim of the Bacteriosafe consortium is to construct, test and develop a unique active wound dressing, which incorporates novel colourimetric sensor and active therapeutic processes for detecting and counteracting pathogenic bacteria in wounds. The inspiration for this project is the natural nano-biological mechanism of bacterial attack on healthy cells. The outer cell walls are ruptured by an array of protein toxins, lipases and other enzymes secreted by these bacteria. We mimic this natural process by using these pathogenic factors to liberate engineered and biologically derived antibiotics/antimicrobials and indicating molecules from highly designed surface immobilized nanocapsules. This will minimize the need for frequent traumatic changes of wound dressing and will provide a simple optical indicator of bacterial infection. In addition to a significant cost reduction, the proposed dressing will minimize the time required for the analysis of bacterial infection. This is particularly critical in burn wounds where delayed detection of bacterial infection can result in patient death. The project will cover both the research into the basic mechanisms of device operation, the development of a prototype device and the process engineering which is necessary to prepare it for large scale industrial production.

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UNIVERSITY OF BATH (Bath), , (UK) CENTRE SCIENTIFIQUE & TECHNIQUE DE L'INDUSTRIE TEXTILE BELGE (CTB), www.centexbel.eu , (BE) DUBLIN CITY UNIVERSITY (DCU), www.dcu.ie , (IE) NORTH BRISTOL NATIONAL HEALTH SERVICE TRUST (Frenchay), , (UK) FREUDENBERG VLIESSTOFFE KG (Freudenberg), www.nonwovens-group.de , (DE) PAUL HARTMANN AG. (Hartmann), http://de.hartmann.info/ , (DE) LAPPEENRANNAN TEKNILLINEN YLIOPISTO (LUT), www.lut.fi , (FI) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPIP), www.mpg.de , (DE) UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ (UMC), http://www.medizin.uni-mainz.de/ , (DE) UNIVERSITY OF SOUTH AUSTRALIA (UniSA), www.unisa.edu.au , (AU) UNIVERSITAET SIEGEN (USIEGEN), , (DE)

BACWIRE • • •

Acronym: BACWIRE Project Title: Bacterial Wiring for Energy Conversion and Remediation Participants: – – – – – –



ElectroCell A/S (ECELL), www.electrocell.com , (DK) INSTITUTO DE INVESTIGACIONES EN CIENCIA Y TECNOLOGIA DE MATERIALES (INTEMA), www.intema.gov.ar , (AR) DE ALCALA (UAH), www.uah.es , (ES) DE ALICANTE (UALI), www.ua.es , (ES) UNIVERSITAET BERN (UBERN), http://www.unibe.ch , (CH) THE UNIVERSITY OF LIVERPOOL (ULIV), www.liverpool.ac.uk , (UK)

Project Abstract: The aim of the project is to develop a new paradigm for the simultaneous cogeneration of energy and bioremediation using electro-active bacteria. A new nano-structured transducer that efficiently connects to these bacteria will be developed, aiming to the production of devices with superior performance across a range of applications including microbial fuel cells, whole cell biosensors and bioreactors. Elucidation of mechanisms by which bacteria transport electrons to solid electrodes is crucial. In this way, well-defined surfaces of single crystals and multilayered gold deposits on quartz elements will be used to resolve the interfacial electrochemistry of both, bacteria and isolated bacterial surface redox molecules. The spatial distribution of cytochromes in the cell surface will be determined by AFM and those involved in the electric connection to electrodes will be studied in detail. Nanoparticle-containing molecular bridges will be designed and constructed to connect electro-active bacteria to the electrode. Afterwards, tethered bacterial biofilms will be used in the development of technological application including reactors for the simultaneous cleaning of wastewater and the generation of clean energy.

BENATURAL • • •

Acronym: BENATURAL Project Title: Bioengineered Nanomaterials for Research and Applications Participants:



Project Abstract: Protein and peptide fibers, nanotubes, and other nanoscale assemblies are considered to be candidate building blocks for a wide range of applications. These biocompatible and water soluble nanoassemblies are formed under mild conditions and are inexpensive and easy to manufacture. Their properties can be modulated by simple chemical modification in the case of peptide structures or by genetic engineering in the case of the protein assemblies. They are also able to serve as a mold for the fabrication of conductive nanowires. Furthermore, some biological nanoassemblies have thermal and chemical stability allowing their integration into fabricated devices. Protein and peptide nano-structures were also shown to be important parts of electrochemical biosensor platforms. Moreover, some peptide structures are remarkably rigid assemblies allowing advanced composite material applications. BeNatural proposes a joint interdisciplinary effort to explore the molecular arrangement and the biochemical and biophysical properties of bionanostructures using advanced biophysical techniques. It also adopts an integrated approach for the development and characterization of novel building blocks that will offer advanced structural and biological properties based on a combination of both new structural insights of the assembly process and novel non-natural amino acid analogues and modifying groups. BeNatural will also evaluate the ability of the bio-nanostructures as superior building blocks for application in biosensing and tissue engineering. The project offers a unique interdisciplinary and complex approach that will allow great progress of the research into the properties of bionanoassemblies, it will result in novel building bocks as well as practical integration strategies, and will materialize into real applications for the benefit of the society.

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AYANDA BIOSYSTEMS SA (AYANDA), www.ayanda-biosys.com , (CH) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) INSTITUT MAX VON LAUE - PAUL LANGEVIN (ILL), www.ill.fr , (FR) SCITECH LINK HB (STL), , (SE) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) THE UNIVERSITY OF NOTTINGHAM (UNOTT), www.nottingham.ac.uk , (UK) PANEPISTIMIO KRITIS (UNIVERSITY OF CRETE) (UOC), www.uoc.gr , (EL) E DE SANTIAGO DE COMPOSTELA (USDC), http://www.usc.es , (ES)

BIO2MAN4MRI • • •

Acronym: BIO2MAN4MRI Project Title: Biomimetic and Biomineralized Magnetic Nanoparticles for Magnetic Resonance Imaging Participants: – –

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Eidgenössische Technische Hochschule Zürich (ETH), www.ethz.ch , (CH) LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG (LBIO), http://www.lbitrauma.org , (AT) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMU), www.uni-muenchen.de , (DE) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) NANOPET PHARMA GMBH (NANOPET), www.nanopet-pharma.com , (DE) SIEMENS AG (SCT), www.siemens.com , (DE) LATVIJAS UNIVERSITATE (UL), http://www.lu.lv , (LV) Pannon Egyetem (UP), www.uni-pannon.hu , (HU)

Project Abstract: Nanoscience and nanotechnology are currently revolutionizing sectors such as medicine, information technologies, environmental or materials sciences, and creating new opportunities for our societies. In this context, magnetic nanoparticles (MNP) are key components to the development of novel nano- and biotechnologies. Magnetosomes are unique hybrid magnetic MNP produced by magnetotactic bacteria (MB). They are employed in applications ranging from extraction of DNA to the development of immunoassays and uses in spintronics are envisaged. However, only a very limited amount of MNP (few mg per day) can be formed by MB, and the formation principles remain to be tackled. Biomimetics, i.e. combining biological principles with chemistry, will pave the way to understand biomineralization of tailored MNP and to find out high-value high-yield synthetic routes to solve scientific and technological challenges. Specifically, we aspire at bridging the gap between different fields of science. For the first time, we will blend biological and genetic approaches with chemical and physical knowledge to understand the key parameters controlling the size, shape, composition and assembly of hybrid MNP in vivo and in vitro. We will combine nanoscience and nanotechnology to modify these properties and develop an ensemble of magnetic nanomaterials of higher values. This approach will lead to original contributions of innovative nature based on the combined skills of the partners to manufacture and characterize the biological, chemical, structural and magnetic properties of the MNP. The industrial partner will have key importance in managing and assessing the applicability of the MNP in Magnetic Resonance Imaging (MRI). Finally, our cell biologist partner will test the biocompatibility of the designed systems. In 5 years, we aim at being able to synthesize hybrid MNP with tailored magnetic and size properties by low-cost high-yield synthesis for applications in MRI.

BIODIAGNOSTICS • • •

Acronym: BIODIAGNOSTICS Project Title: Biological diagnostic tools using microsystems and supersensitive magnetic detection Participants:



Project Abstract: The objective of the proposed project is to develop new medical diagnostic tools based on the most sensitive detector technologies available today. A common denominator for the technologies is reading out the biological state in the magnetic domain. This will be accomplished by using both magnetic nanoparticles as substrates or tags for biological reactions and reading out the atomic nuclear spin. The latter technology is a development from the inductive readout in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). The technology used in this project is a pure magnetic field read-out system, which quite contrary to the inductive method has a sensitivity which is more or less independent of frequency and magnetic field down to very low fields. The several competing technologies will be benchmarked against each other with a model system consisting of biotin and streptavidine in order to gain a unique understanding of the differences and advantages with the different systems. To validate the concept(s), real diagnostic test will be done on in vitro detection of F1 antigen (y. pestis) Mycobacterium tuberculosis in urine samples and detection of Yersinia pestis F1 antigen in environmental samples (bio terrorism). Further to the validation, neuroimaging and instrumentation for diagnosis of neurological diseases will be investigated in vivo.

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CHALMERS TEKNISKA HOEGSKOLA AB (CHALMERS), www.chalmers.se , (SE) CHEMICELL GMBH (CHEMICELL), www.chemicell.com , (DE) FRIEDRICH-SCHILLER-UNIVERSITAET JENA (FSU JENA), www.uni-jena.de , (DE) FORSCHUNGSZENTRUM JUELICH GMBH (FZJ), www.fz-juelich.de , (DE) IMEGO AB (IMEGO), www.imego.com , (SE) JULICHER SQUID GMBH (JSQ), www.jsquid.com , (DE) KAROLINSKA INSTITUTET (KI), www.ki.se , (SE) KUNGLIGA TEKNISKA HOEGSKOLAN (KTH), www.kth.se , (SE) DANMARKS TEKNISKE UNIVERSITET (MIC), www.dtu.dk , (DK) MICRO-SPHERE SA (MICRO-SPHERE), , (CH) PHYSIKALISCH-TECHNISCHE BUNDESANSTALT (PTB), www.ptb.de , (DE) ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE (RHUL), , (UK) SENOVA GESELLSCHAFT FUR BIOWISSENSCHAFT UND TECHNIK MBH (SENOVA), www.senova.de , (DE)

BIODOT • • •

Acronym: BIODOT Project Title: Sensing BIOsystems and their Dynamics in fluids with Organic Transistors Participants: – – – – – – – –



CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES (IEM-HAS), www.koki.hu , (HU) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMU), www.uni-muenchen.de , (DE) PHILIPS ELECTRONICS NEDERLAND B.V. (PHILIPS), www.philips.com , (NL) RIJKSUNIVERSITEIT GRONINGEN (RUG), www.rug.nl , (NL) SCRIBA NANOTECNOLOGIE SRL (SCRIBA), www.scriba-nanotec.com , (IT) ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA (UNIBO), www.unibo.it , (IT)

Project Abstract: The vision of BIODOT is a hybrid bio-organic technology for transduction of dynamical phenomena of biosystems in-vitro. The device that will be developed is based on organic ultra thin film transistors integrated with microfluidics. It will respond to subtle changes of the electrostatic charge at the interface between the biosystem in the solution and the organic semiconductor. These changes are due, for instance, to the flow of ions, the adsorption and diffusion of charged or polarisable molecules, the motion of large biomolecules, the activity of cells grown on the organic semiconductor. The transduction of the dynamical behaviour of a) peptides involved in neurological functions, b) phospholipids and functional membranes, c) neurons and glia cells will be demonstrated during the project. The signal will be correlated with dynamical data from fluorescence and scanning probe microscopy, computer simulations and structural techniques at the micro- and nano-scales. The integration of neural cells into this technology will extend the scope of the project towards long-term applications in biomedicine. These and other aspects make BIODOT a project aimed to achieve breakthroughs with respect to the state-ofthe-art.

BIOELECTRICSURFACE • • •

Acronym: BIOELECTRICSURFACE Project Title: Electrically modified biomaterials surface Participants:



Project Abstract: According to the World Health Organisation (WHO), cardiovascular diseases cause half the deaths in the EU. It is also the main cause of years of life lost (over 30 per cent) in early death thus causing huge pressure on the labour force and family earnings. The problem is becoming more acute in Central and Eastern European countries. Due to the ageing population in the EU, osteoporosis related bone fractures have almost doubled in the last decade. It is estimated that 40 percent of women over 50 years in age will suffer from fractures due to low density bone. The European Commission considers the application of nanotechnology an important research strategy to address these problems. For this, design and control of biomaterial at the nanometer scale is set as a strategic research priority. Europe is, however, seriously underrepresented in the global market for nanotherapeutics, where the United States dominates with three-quarter of the market share. While the drive for nanoscale understanding of biological interaction can be high, the application of this knowledge in marketable devices should also be prioritised. Here, we propose electrical modification of biomaterials surface to manipulate surface charge that will mediate bio/non bio interactions in vivo. We propose novel nanoscale techniques to probe this surface charge at the nanometer scale so that we have a quantitative insight to biological interaction at the biomedical device surfaces. Such an approach will help us to scale up electrical modification in cardiovascular stents, urological stents, orthopedic implants and photosterilisation devices. The research proposed here will not only provide nanoscale understanding of biological interactions on biomaterials surface but also result in novel applications and devices, which will penetrate into the market in short to medium term.

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BALTON SPOLKA ZOO (Balton), www.balton.pl , (PL) BeoCare Limited (BC), www.beocare.ie , (IE) BEN-GURION UNIVERSITY OF THE NEGEV (BGU), www.bgu.ac.il , (IL) COOK IRELAND LIMITED (COOK), www.cookmedical.com , (IE) UNIVERZITA KOMENSKEHO V BRATISLAVE (CU), http://www.uniba.sk , (SK) TEKNOLOGISK INSTITUT (DTI), www.teknologisk.dk , (DK) NATIONAL UNIVERSITY OF IRELAND, GALWAY (NUIG), www.nuigalway.ie , (IE) PETER BREHM (PB), www.peter-brehm.de , (DE) TECHNISCHE UNIVERSITAET DRESDEN (TUD), , (DE) UNIVERSITY OF LIMERICK (UL), www.ul.ie , (IE) UNIVERSITATEA POLITEHNICA DIN BUCURESTI (UPB), , (RO) AKADEMIA MEDYCZNA IM PIASTOW SLASKICH WE WROCLAWIU AM WROCLAW (WMU), www.am.wroc.pl , (PL) POLITECHNIKA WROCLAWSKA (WRUT), , (PL)

BIO-LITHO • • •

Acronym: BIO-LITHO Project Title: Biomineralization for lithography and microelectronics Participants: – – – – – – – –



CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) INNOS LIMITED (INNOS), www.innos.co.uk , (UK) JOHANNES GUTENBERG UNIVERSITAET MAINZ (JOGU), www.uni-mainz.de , (DE) LIMNOLOGICAL INSTITUTE OF THE SIBERIAN BRANCH OF THE RUSSIAN ACADEMY OF SCIENCES (LIN-SB-RAS), www.lin.irk.ru , (RU) NANOTECMARIN GMBH (NTM), , (DE) THE NOTTINGHAM TRENT UNIVERSITY (NTU), www.ntu.ac.uk , (UK) UNIVERSITA DEGLI STUDI DI GENOVA (UNIGE), www.unige.it , (IT) BIOTECMARIN GMBH (BIOTEC), http://www.biotecmarin.de , (DE)

Project Abstract: The impact of biomineralization processes on lithographic and microelectronic production processes has not yet been explored. As opposed to conventional industrial manufacturing, the biological synthesis of silica occurs under mild physiological conditions of low temperatures and pressures, with clear advantages in terms of cost-effectiveness, parallel production, and impact on the environment. The integration of nature-mimic biomineralization processes with micro- and nanofabrication will be a unique route to make them usable in the medium-long term for industrial application and production. In particular, some peculiar proteins of sponges (silicateins) catalyze the reaction of silica polymerization to give ordered structures. Besides this catalytic activity, when the proteins are assembled into mesoscopic filaments, they serve as scaffolds that spatially direct the synthesis of polysiloxanes over the surface of the protein filaments. Hence, these biomolecules present the combined characteristics of: (i) chemical action (catalysis) for the formation of silica, and (ii) patterning action, by driving the silica on the surface of the filaments. We plan to exploit this unique combination within a novel technology, whose demonstrator will be the realization of patterned, aligned assembly of silica fibers, and their employment as insulating layers for prototype transistor devices. Two parallel strategies will be pursued for the production of large amounts of silicatein: (i) expression of the recombinant proteins, and (ii) development of in vitro primmorph cultures. Soft lithography techniques will be used for the controlled patterned deposition of molecules. Specific approaches will be designed and implemented, for the hierarchical assembly of silicatein fibers into functional networks. The multidisciplinary team involved in this project has the know-how in biosilicification/lithography and the intellectual property rights in enzymatic silica formation.

BIOMACH • • •

Acronym: BIOMACH Project Title: "Molecular Machines - Design and Nano-Scale Handling of Biological Antetypes and Artificial Mimics" Participants:



Project Abstract: We propose the set-up of a cross-disciplinary research initiative dealing with molecular machines, in particular biological and artificial motors. A close collaboration between chemists known for their expertise in designing functional (bio)molecular motors, biophysicists experienced in dealing with molecular biomachines and physicists with an excellent background in experimental techniques addressing single molecules will advance the basic understanding in this domain to be employed for the steering of molecular engines in the nanometer regime. State-of-the-art theoretical calculations will guide the experimental work and allow for its indepth interpretation. The objective of the project is to develop new concepts and advance research tools to master the challenge of handling nano-engines at the single-molecule level. We expect that the implementation and integration of the complementary scientific approaches within the consortium will lead to synergetic research achievements. While biological systems are abundant in nature, their fueling relies mostly on specific chemical reaction schemes and environments. On the other hand, the challenge of the design of functional artificial molecular motors has been met by synthetic chemists represented in the consortium. Of particular interest is the fact, that de novo designed artificial engines are frequently photo-physically and/or electrically driven, i.e., the corresponding fueling systems can be integrated in single-molecule experimental set-ups. The long-term vision of our research initiative is, firstly, to merge the advantages of the accessible biological and artificial systems by (self-)assembling of hybrid bio-inorganic working devices and, secondly, to rationalize and to operate them on the single-molecule level.

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STICHTING VOOR FUNDAMENTEEL ONDERZOEK DER MATERIE - FOM (AMOLF), www.fom.nl , (NL) ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA (CIAM), www.unibo.it , (IT) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) EIDGENöSSISCHE TECHNISCHE HOCHSCHULE ZüRICH (ETH), www.ethz.ch , (CH) FORSCHUNGSZENTRUM KARLSRUHE GMBH (FZK-INT), www.fzk.de , (DE) INSTITUT CURIE (ICR-GC), www.curie.fr , (FR) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPI-FKF), www.mpg.de , (DE) TECHNISCHE UNIVERSITEIT DELFT (TU/D-MB), www.tudelft.nl , (NL) TECHNISCHE UNIVERSITEIT EINDHOVEN (TU/E), www.tue.nl , (NL) UNIVERSITE LOUIS PASTEUR (ULP), www-ulp.u-strasbg.fr , (FR)

BIOMAGSENS • •

Acronym: BIOMAGSENS Project Title: Ultra sensitive Magnetic Sensors for medical applications



Participants: – – – – –



COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) CEDRAT TECHNOLOGIES SA (CEDRAT), www.cedrat.com , (FR) INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES PARA OS MICROSISTEMAS E NANOTECNOLOGIAS (INESC MN), www.inesc-mn.pt , (PT) ELEKTA NEUROMAG OY (NEUROMAG), www.elekta.com , (FI) THE PROVOST FELLOWS & SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (TCD), www.tcd.ie , (IE)

Project Abstract: The proposal is a RTD project and is submitted in response to the call IST-NMP2 Bio-sensors for Diagnosis and Healthcare. The aim of the project is to develop a new generation of ultra-sensitive magnetic sensors with very low noise based on magnetic tunnel junctions for Diagnosis and Healthcare applications. These elements will first be used to develop hybrid sensors able to detect femtoTesla fields for magnetic imaging of the human body, mainly heart and brain. Secondly, we will develop the next generation of magnetic based biochips. Finally we will explore a new approach for biochips based on fluctuating particles localized in space by dipolar reconstruction. The consortium is composed of three research and development institutes, two small and medium enterprises and a large scale industry. The main outputs of this project will be reliable, highly sensitive magnetic sensors for very different applications, hybrid sensors for femtoTesla field detection, a magneto-cardiographic (MCG) device, a new generation of magnetic based biochips and quantitative evaluation of dipolar reconstruction methods at the micron length scale.

BIOSCOPE • •

Acronym: BIOSCOPE Project Title: Self-reporting biological nanosystems to study and control bio-molecular mechanisms on the single molecule level



Participants:



Project Abstract: BIOSCOPE will develop new nano-scale tools allowing unprecedented insight into bio-molecular mechanisms at biological interfaces on the scale of single molecules. The key element in the BIOSCOPE strategy is to involve the biomolecular system itself as part of the nanoscopic instrument which in various ways reports to the out-side world about its current local state. BIOSCOPE benefits from the synergy between recent advances in nanotechnology and the adaptive dynamic behaviour of many natural and artificial biological systems, which change their structure, physical chemical state and properties as a reaction to the local nanoscopic environment.The objectives of BIOSCOPE are 1.) To develop instrumentation and methods for manipulation of enzymes and enzyme activity at the nano-scale providing insight into the biomolecular mechanisms on a single molecule level.2.) To develop novel forms of integration, at the nano-level, of enzymes and non-biological systems such as nanoparticles, artificial membranes, electrical field or force field traps. 3.)To confine several enzymes to surfaces of nanoparticles or membranes on a less than 10 nm scale in order to achieve a selforganized assembly with concerted as well as controllable bioaction superior to the simple sum of the same individual enzymes. This addresses NMP area 3.4.1.4, 3.4.1.1 and 3.4.1.2. The impact of BIOSCOPE is indeed envisaged as a longterm not only by providing new tools for the scientist, but also by making possible the rational design of new enzymes (and other proteins) based on their true bio-molecular mechanism. The knowledge-base provided by BIOSCOPE will allow researchers and industries to move from design of biomolecular systems based on end-state global properties, which is just one, some times distant, consequence of the true biomolecular mechanism. BIOSCOPE will provide new leads for major break-through in analyses and syntheses, which in turn will lead to the creation of several new SME.

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INSTITUTE OF BIOCHEMISTRY (IBLT), www.bchi.lt , (LT) KATHOLIEKE UNIVERSITEIT LEUVEN (KULEUVEN R&D), www.kuleuven.be , (BE) STICHTING KATHOLIEKE UNIVERSITEIT (KUN), www.ru.nl , (NL) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMU-MUENCHEN), www.uni-muenchen.de , (DE) NOVOZYMES A/S (NOVOZYMES), www.novozymes.com , (DK) SYDDANSK UNIVERSITET (SDU), www.sdu.dk , (DK) KøBENHAVNS UNIVERSITET (UCPH), www.ku.dk , (DK) LUNDS UNIVERSITET (ULUND), www.lu.se , (SE) THE UNIVERSITY OF LIVERPOOL (UNILIV), www.liverpool.ac.uk , (UK)

BISNES • • •

Acronym: BISNES Project Title: Bio-Inspired Self-assembled Nano-Enabled Surfaces Participants:



Project Abstract: Advanced nanofabrication can produce now nano-structures similar in size with single biomolecules or their self-assembled architectures. Capitalising on this strategic opportunity, BISNES focuses on the design, fabrication and implementation of biomimetic nanostructures which complement biomolecular surfaces and modulate the biomolecular activity. The BISNES project will (i) develop software products for the representation and quantification of bimolecular surfaces, especially those that self-assemble in long-range nanoaggregates, interacting with artificial nanostructures; (ii) design and fabricate nanostructured surfaces and objects that complementary replicate biomolecular surfaces; and (iii) design, fabricate and implement novel hybrid bio-devices which exhibit quantum-leap increase in capabilities (e.g., sensitivity, response time, cost) or entirely new ones. The project will deliver demonstrated technical solutions with impact on a wide range of applications and products: ultra-sensitive bio-diagnostics and drug discovery devices; inherently bactericidal surfaces, medical devices for the in vitro study of amyloid and cytoskeleton proteins central to critical disease (e.g., neurodegenerative diseases, cancer); and hybrid nanodevices that exhibit new electromagnetic properties useful for future IT devices. The research consortium has the critical mass of knowledge and experimental capabilities, as well as the right combination of activities (academia and industry, both SMEs and industry enduser), which allows us to follow the complete innovation path from fundamental science to its implementation in demonstration devices. BISNES’ cross-disciplinary approach of will synergise the European first-class position in nanofabrication and biomolecular engineering, through cross-field applications and will contribute to the consolidation of the high added-value of European biomedical, advanced manufacturing and IT industry.

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STICHTING BIOMADE TECHNOLOGY (BMD), www.biomade.nl , (NL) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) IMS NANOFABRICATION AG (IMS-NANO), , (AT) MONASH UNIVERSITY (MUAUS), www.monash.edu.au , (AU) NIL TECHNOLOGY APS - NILT NANOMASK APS (NILT), www.nilt.com , (DK) PHILIPS ELECTRONICS NEDERLAND B.V. (Philips), www.philips.com , (NL) ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA (UNIBO), www.unibo.it , (IT) THE UNIVERSITY OF LIVERPOOL (UoL), www.liverpool.ac.uk , (UK) UNIVERSITATEA POLITEHNICA DIN BUCURESTI (UPB), , (RO)

BMR • • •

Acronym: BMR Project Title: Ballistic magnetoresistance in thin film nanocontacts Participants: – – – – –



SCIENCE AND TECHNOLOGY FACILITIES COUNCIL (CCLRC), www.scitech.ac.uk , (UK) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) UNIVERSITAET HAMBURG (IAP), http://www.uni-hamburg.de/ , (DE) KAZAN STATE UNIVERSITY (KSU), , (RU) UNIVERSITY OF PLYMOUTH (UOP), , (UK)

Project Abstract: The project explores a superior property in nanoscale magnetic thin film devices - the spin dependent ballistic electronic transport, which is a size-dependent phenomenon that may only occur in nanoscale materials and devices due to quantum mechanics effect. The subject area and the objectives of the project have a close relevance to the NMP priority area 3.4.1.1 for 2003, which calls for long term, ambitious interdisciplinary research addressing, theoretically (incl. modelling) and experimentally, size-dependent phenomena, including quantum and/or mesoscopic scale phenomena. The nanotechnology and nanoscience explored in the project represent a new approach to materials science and engineering, as well as for design of new devices and processes for future data storage, spintronic devices and computers. The consortium consists of European leading experimentalists (P1) in BMR of wire nanocontacts, leading BMR theorists (P5), laboratories with the state-of-theart nanofabrication techniques (P3) and magnetotransport thin films and devices (P2 and P6), and leading researchers in spin injection and spin transport studies (P4), aiming to integrate the complementary knowledge, infrastructure and expertise for the exploration of the spin dependent ballistic transport properties in thin film nanocontacts. Our overall rrare to employ the state-of-the-art nanofabrication technology for the fabrication of thin film nanoconstrictions with diameter of 50 ~ 5 nm, and to carry out a concerted experimental and theoretical study of the spin transport properties in relation to physical sizes, micromagnetic structures, interfacial and ferromagnetic/semiconductor electrode materials, and polarization in the vicinity of the nanocontacts, aiming to explore high ballistic magnetoresistance (BMR), we will study the magnetoelastic deformations of the contacts that can contribute to the transport process. As well as the contribution by pulsed laser illumination.

BNC TUBES • • •

Acronym: BNC TUBES Project Title: Novel, Heteroatomic Boron, Nitrogen and Carbon Nanotubes (BNC Tubes) Participants: – – – – – – – – –



ARKEMA FRANCE SA (ARK), www.arkema.com , (FR) BENEQ OY (BENEQ), www.beneq.com , (FI) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR (FUNDP), www.fundp.ac.be , (BE) HEWLETT-PACKARD (MANUFACTURING) LIMITED (HP-DIMO), www.hp.com , (IE) NATURAL SCIENCES CENTER OF A.M. PROKHOROV GENERAL PHYSICS INSTITUTE OF RUSSIAN ACADEMY OF SCIENCES (NSC GPI), www.gri.ru , (RU) TEKNILLINEN KORKEAKOULU (TKK), www.tkk.fi , (FI) OULUN YLIOPISTO (UOULU), www.oulu.fi , (FI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD (UOXF.DJ), www.ox.ac.uk , (UK)

Project Abstract: This project aims to develop novel, continuous, chemical vapour deposition (CVD) based synthesis methods for three dimensional regular nanostructures in the form of hetero-atomic nanotubes (NTs) composed of boron, nitrogen and carbon: BN, N-doped carbon, B-doped carbon and mixed B-N-C nanotubes. In doped nanotubes either or both boron and nitrogen atoms replace carbon atoms within the structure and are covalently bound. The main target is to control the electrical properties of nanotubes (i.e. metallic or n- or psemiconducting), with special attention to control the number of layers: 1 (SWNT), 2 (DWNT) or several (MWNT). The important industrial potential is demonstrated by developing transparent, conductive, flexible nanotube mats. We will explore the optical (i.e. band gap), electrical conductivity, electron field emission as well as non-linear optical properties of produced nanotubes. A significant dedicated modelling aspect is included. We will study NT synthesis using system level computational fluid/aerosol dynamics methods and investigate NT properties based on detailed atomistic modelling using ab initio, molecular dynamics and Monte Carlo simulations. Metrology issues include the development as well as comparison of advanced transmission electron microscopic (TEM) and scanning tunnelling (STM) methods to determine the atomic structure and non-linear optical properties of produced nanotubes. The project team has 9 world-class, multidisciplinary partners in the field, including the Helsinki University of Technology, CNRS, Oxford University, Facultés Universitaires Notre-Dame de la Paix, University of Oulu and Prokhorov General Physics Institute of Russian Academy of Sciences as well as major companies Hewlett-Packard and ARKEMA and an SME, Beneq Oy.

BOND • • •

Acronym: BOND Project Title: BIOELECTRONIC OLFACTORY NEURON DEVICE Participants:



Project Abstract: Recently, the use of smell in different fields has been rediscovered due to major advances in odour sensing technology and artificial intelligence. However, current electronic noses, based on electronic sensors, have significant limitations concerning sensitivity, reliability and selectivity, amongst others. These limitations are at the basis of recurrent troubles of this technology to reach essential applications in different areas, such as food safety, diagnosis, security, environment… The present project proposes a new bioelectronic nose based on olfactory receptors in order to mimic the animal nose. For this aim, micro/nano, bio and information technologies will converge to develop an integrated bioelectronic analytical nanoplatform based on olfactory receptors for odour detection. Briefly, the basis of the nanobioplatform will be the olfactory receptors, prepared in the form of nanosomes immobilized onto the nanotransducers (NANO and BIO). An array of smart nanotransducers will acquire and process electronically the detected odour (NANO and INFORMATION). Such an easy-to-use nanobioplatform, with user-friendly interface and odorant identification algorithm, will detect and discriminate the odorants (NANO and INFORMATION). The scientific and technological challenges of the BOND project can only be solved by integrating a multidisciplinary consortium at European level with expertise in areas such as biotechnology, surface chemistry, nanofabrication, electronics and theoretical modelling. The partners involved in the BOND project are experienced partners used to work in large consortia with distributed laboratories all over the European Union and offer competences and resources to build a complementary partnership for the successful implementation of the nanobioplatform. Six of the eight partners have already successfully worked together in the European SPOT-NOSED project to produce a proof of concept of a bioelectronic sensor based on olfactory receptors

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AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), www.inra.fr , (FR) POLITECNICO DI MILANO (POLIMI), , (IT) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (TNI-UCC), www.ucc.ie , (IE) UNIVERSITAT DE BARCELONA (UB), http://www.ub.es , (ES) UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL), , (FR) UNIVERSITA DEL SALENTO (UNILE), www.unisalento.it , (IT) UNISCAN INSTRUMENTS LIMITED (UNISCAN), www.uniscan.com , (UK)

CAMINEMS • • •

Acronym: CAMINEMS Project Title: Integrated Micro-Nano-Opto Fluidic systems for high-content diagnosis and studies of rare cancer cells Participants: – – – – –

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ALMA CONSULTING GROUP SAS (ALMA), www.almacg.com , (FR) INSTITUT CURIE (Curie), www.curie.fr , (FR) FLUIGENT SA (FLUIGENT), www.fluigent.com , (FR) INSTITUT GUSTAVE ROUSSY (IGR), http://www.igr.fr , (FR) INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA E DO PORTO (IPATIMUP), http://www.ipatimup.pt , (PT) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMUM), www.uni-muenchen.de , (DE) USTAV MAKROMOLEKULARNI CHEMIE AV CR, v.v.i. (MACRO), http://www.imc.cas.cz , (CZ) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD (UOXF.DF), www.ox.ac.uk , (UK) UNIVERZITA PARDUBICE (UPCE), www.uni-pardubice.eu , (CZ)

Project Abstract: The project aims at developing a new integrated and automated microfluidic tool for cancer cells screening. This instrument will have a reliability and power much beyond state of the art (capture yield increased by a factor from 10X to 100X and multimodal typing of the cells in 3D high resolution images), allowing earlier and more accurate diagnosis, prognosis and selection of treatments of cancers. CaMiNEMS’s new approach will involve a new generation of bio-functionalised multifunctional magnetic nano and microparticles which will be self-assembled by a Hierarchial Templated Self-Assembly mechanism into high-aspect ratio reversible arrays. For highly automated molecular typing of cancers, this key innovation will be integrated with a unique fully automated flow control system working from nanolitres to millilitres and with innovative nano-optics tools and image analysis software. Technological developments will be validated regarding the analysis of circulating tumour cells or “micrometastases” and the molecular typing of minimally invasive microsamples from tumours. The project will also yield new tools for research and drug-discovery, allowing for the first time to study at the single molecule scale in single cancer cells from patients the fate and action of new generation anticancer drugs using innovative dynamic tracking of Quantum dots. To combine research excellence and societal impact, the consortium involves research groups with complementary competences in microfluidics, nano-optics, biophysics, nanoparticles, biochemistry, informatics, several forefront cancer centres for clinical validation and a researchintensive SME for exploitation.

CANAPE • • •

Acronym: CANAPE Project Title: Carbon Nanotubes for Applications in Electronics, Catalysis, Composites and Nano-Biology Participants:



Project Abstract: A major limitation on the application of the unique properties of carbon nanotubes has been their high cost and lack of availability. This IP brings together leading laboratories and companies within Europe to produce nanotubes on a bulk scale of ultimately tons per year. The large scale growth of carbon nanotubes will be developed by chemical vapour deposition (CVD). The applications in electronics as interconnects and vias for integrated circuits, for field effect transistors, and spin coherent transport will be developed. Field emission will be developed further for use in microwave amplifiers and micron scale x-ray sources. Electronic applications will be enabled by controlled growth in plasma enhanced CVD and thermal CVD. Multi-wall CNTs will be used as a catalyst in large scale chemical reactions such as the dehydrogenation of ethyl benzene to styrene. Control of the nanotube internal orientation to give the herring bone microstructure is needed for catalysis, as plane edges are catalytically active. Functionalization of CNTs will be extended, in order to improve the performance of structural, electrically conducting and thermally conducting nanotube- polymer composites. Dispersion of nanotubes at high loading will be achieved in polymers to obtain high strength composites. Nanotubes are known to act as high energy density actuators, or 'artificial muscles'. Nanobiological devices will be fabricated based on self-assembly and molecular absorption. A toxicological study of CNTs particularly with respect to possible health hazards will be carried out, and nanotube/polymer composites will be tested for biocompatibility. Public acceptance of nanomaterials and nanotechnology will be encouraged by publicity and poling. Training, workshops and conferences will be held, and to promote technology transfer from universities and research institutes to companies. SMEs will be dominant in the CVD, catalysis and composite applications

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CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) SIRRIS (CRIF), www.sirris.be , (BE) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) HITACHI EUROPE LIMITED (HEL), www.hitachi-eu.com/index.jsp , (UK) IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (IMPERIAL), www.imperial.ac.uk , (UK) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPI), www.mpg.de , (DE) NANOSCAPE AG (NSAG), www.nanoscape.de , (DE) STMICROELECTRONICS SRL (STM), www.st.com , (IT) THOMAS SWAN & CO LTD (SWAN), www.thomas-swan.co.uk , (UK) THALES SA (TRT-FR), www.thalesgroup.com , (FR) TECHNISCHE UNIVERSITAET DARMSTADT (TUD), www.tu-darmstadt.de , (DE) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UCAM-DENG), www.cam.ac.uk , (UK) UNIVERSITE DE LIEGE (ULG), www.ulg.ac.be , (BE) UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES (UM2), www.univ-montp2.fr , (FR)

CARBONCHIP • • •

Acronym: CARBONCHIP Project Title: Carbon Nanotubes technology on Si IC's Participants:



Project Abstract: In microelectronic research huge expectations have been created for carbon nanotube (CNT) based nanotechnologies, actually to a level that the microelectronics industry has adopted CNT based nanotechnologies as an important and high potential route for post CMOS nanoelectronics. There is a major gap in basic knowledge to the extent that a detailed understanding of CNT growth mechanisms is still absent and control of the synthesis process to produce nanotubes with the desired diameter and chirality is lacking. CARBonCHIP will address the potential of the integrated CNT technology through an interdisciplinary approach based on (i) the research and development in catalysis, (ii) the growth of CNTs, (iii) the technology of CNTs on-chip, (iv) the related analysis methodology for control of properties and (v) the CNT device for nanoelectronics. The objectives of CARBonCHIP match the real challenge for CNTs to be valuable for Nanoelectronic applications. The outcome of the project will have a large impact on future nanoelectronic strategies, since it will assess - the eligibility of CNTs for up-scaled process technology with Si - the feasibility of nanoelectronic application domains. The ultimate goal is to produce a materials based roadmap for further development of the CNT as a viable building block in nano-transistor IC devices, where CNT/Si integrated devices will extend Moore's Law towards the year 2020 and beyond, when CNT technology will complement, and eventually replace nano-lithographic techniques to facilitate 16nm, 11nm and 8nm transistor node development. The consortium consists of an industrial end user (Intel), two renowned research centers (LETI and IMEC), two SMEs (Alchimer and Nanocyl) and a University (KULeuven). The strength of this consortium is that it will bring basic research and the innovative product development of SMEs to the end user, through the research and development of the research institutes

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ALCHIMER SA (ALCHIMER), www.alchimer.com , (FR) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW (IMEC), www.imec.be , (BE) INTEL PERFORMANCE LEARNING SOLUTIONS LIMITED (INTEL), www.itic.intel.com , (IE) KATHOLIEKE UNIVERSITEIT LEUVEN (KUL), www.kuleuven.be , (BE) NANOCYL S.A. (NANOCYL), www.nanocyl.com , (BE)

BIO-MEDNANO • • •



Acronym: BIO-MEDNANO Project Title: Integrating enzymes, mediators and nanostructures to provide bio-powered bio-electrochemical sensing systems Participants: – – – – – – –

ABO AKADEMI (AA), , (FI) BVT TECHNOLOGIES, A.S. (BVT), www.bvt.cz , (CZ) THE HEBREW UNIVERSITY OF JERUSALEM. (HU), www.huji.ac.il , (IL) NATIONAL UNIVERSITY OF IRELAND, GALWAY (NUIG), www.nuigalway.ie , (IE) UNIVERSITY OF SOUTHAMPTON (SOTON), http://www.southampton.ac.uk , (UK) UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA (UNIROMA), www.uniroma1.it , (IT) VALTION TEKNILLINEN TUTKIMUSKESKUS (VTT), www.vtt.fi , (FI)

Project Abstract: BIO-MEDNANO STREP-project focuses on research at the frontiers of knowledge of enzymes, mediators, surfaces and immobilisation strategies aimed at improving enzymatic electron transfer reactions for application towards integrated bio-powered biosensing systems for diagnosis and healthcare. Such improvements will be provided by: screening for novel enzymes; modification of enzymes; design of novel nano-structured scaffolds for enzyme immobilization, to provide devices with improved stability and electron transfer efficiency (sensitivity and/or power output). The main scientific objective of the BIO-MEDNANO STREP -project is to increase understanding and overcome the present limitations of biofuel cell and biosensor devices based on biological electron transfer systems. The technological aim of the project, integrated bio-powered biosensing systems, will be achieved by using multidisciplinary approaches exploiting knowledge in modern biotechnology, electrochemistry, and surface and material science. Optimisation of electron transfer between the enzyme molecule and the electrode will be the challenging focus of this research, due to its generic applicability and importance. The long-term innovation of the project is to generate profound, molecular level knowledge on the electron transfer process taking place between biological molecules and electrochemically active materials and further apply this knowledge to integrated bio-powered biosensing systems. The initial targets for integrated biosensing systems will be based on development of prototype biosensors for the intermittent determination of glucose and catecholamine neurotransmitter levels in clinical samples, powered by a biofuel cell functioning on in-vivo available biofuels. The ambitious long-term aim of the development of such prototypes is to provide integrated bio-powered autonomous implantable biosensing systems for healthcare monitoring.

CARE-MAN • • •

Acronym: CARE-MAN Project Title: Healthcare by Biosensor Measurements And Networking Participants: – APPLERA EUROPE B.V. (AB), , (NL) – AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH (ARC), http://www.ait.ac.at/ , (AT) – ATTEMPTO SERVICE GMBH (ATT), www.attempto-service.de , (DE) – BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES S.A. (BIOT), , (ES) – BIT ANALYTICAL INSTRUMENTS GMBH (BIT), www.bit-instruments.com , (DE) – BAYER TECHNOLOGY SERVICES GMBH (BTS), www.bayertechnology.com , (DE) – CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) – DUBLIN CITY UNIVERSITY (DCU), www.dcu.ie , (IE) – DATAMED SRL (DM), www.datamedsrl.com , (IT) – EXBIO PRAHA AS (EXBIO), www.exbio.cz , (CZ) – HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH (GSF), www.helmholtz-muenchen.de , (DE) – HOSPITAL CLINIC I PROVINCIAL DE BARCELONA (HCPB), , (ES) – INETSYS SA (INET6), www.inet6.fr , (FR) – FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (IPM), www.fraunhofer.de , (DE) – JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) – JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH (JRS), www.joanneum.at , (AT) – UNIVERZITA KARLOVA V PRAZE (LFHK), www.cuni.cz , (CZ) – LINKOPINGS UNIVERSITET (LIU), www.liu.se , (SE) – MEDIZINISCHE UNIVERSITAET GRAZ (MUG), http://www.medunigraz.at , (AT) – BIOSENSIA LIMITED (NC), , (IE) – PARDUBICKA KRAJSKA NEMOCNICE A.S. (PARDUBICE REGIONAL HOSPITAL STOCK COMPANY) (PRH), , (CZ) – DADE BEHRING MARBURG GMBH (SHC), , (DE) – SIEMENS AG (SIEMENS), www.siemens.com , (DE) – SIEMENS HEALTHCARE DIAGNOSTICS GMBH (SMSD), , (DE) – KLINIKUM RECHTS DER ISAR (TUM), , (DE) – UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL), , (FR) – UNIVERSITA DEGLI STUDI DI FIRENZE (UNIFI), http://www.unifi.it , (IT) – UNIVERSITE DE NEUCHATEL (UNINE), www.unine.ch , (CH) – EBERHARD KARLS UNIVERSITAET TUEBINGEN (UT-IPTC), www.uni-tuebingen.de , (DE) – UPPSALA UNIVERSITET (UU), www.uu.se , (SE) VYZKUMNY USTAV VETERINARNIHO LEKARSTVI (VRI), www.vri.cz , (CZ) –

CARE-MAN cont. •

Project Abstract: Diagnostics at hospitals is based either on large-scale automated equipment or ELISA techniques based on bioassays which are not suitable for bedside and emergency medicine. Therefore CARE-MAN will provide a validated, intelligent, next-generation diagnostic device and system based on biosensor technology with new, radically enhanced detection capabilities and integrated sample-handling to address the most common diagnostic problems in the EU like cardiovascular disease, coagulation disorders, chronic/acute inflammation, cancer, thyroid disorders. The integration of eHealth capabilities is achieved through networking functions and interfaces to current and future medical data systems. To follow the requirements of the variety of serious diseases, modules of sample preparation, fluidics, assay formats and optical and electrochemoluminescent transduction principles will be integrated in a new modular multi-analyte technological system in cooperation with diagnostic and IT companies. The system will reduce sample volumes and improve limit of detection, make the point-of-care diagnostics fast, easy to handle and cost-effective and will provide an anticipating diagnostic help by networking and information technology. Hospitals are involved in the validation process taking into account the differences in healthcare and provide input to improve the instrumentation. Working biosensing systems are modified to allow development of immunoassay strategies from the start and give chance to improve instrumental setups even in the first period. Later, system integration will not only set up a technological modular system for hospitals but also for family doctors and in future, for bedside home surveillance. The involvement of legislatory bodies and representatives of health insurances in an advisory board and the complementary expertise of the partners govern the success and the validity of the project.

CELLFORCE • • •

Acronym: CELLFORCE Project Title: Development of a single cell based biosensor for subcellular on-line monitoring of cell performance for diagnosis and healthcare Participants: – – – –



EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) FACULDADE CIENCIAS E TECNOLOGIA DA E DE COIMBRA (FCTUC), http://www.uc.pt/fctuc , (PT) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER), www.fraunhofer.de , (DE) POLITECHNIKA WARSZAWSKA (PW (WUT)), http://www.pw.edu.pl , (PL)

Project Abstract: Characterisation of cells is of crucial importance in various fields of health care. Since many biological processes are characterized by the sequential appearance of certain cell constituents that are present only during a short period of time statements based by taking only one time point into account are tainted with errors. The present goal is the development of a complete new concept and its implementation for nanotechnology biosensor-based integrated systems for health. The long-term objective of the present project is the development of a new medical instrument and/or intelligent diagnosis equipment for healthcare of the future, using advanced biological biosensors. It is based on the integration of technological developments regarding precision engineering, optical and computational methods. The sensor will result in a quantum leap regarding knowledge of the interactions between biological and non-biological systems. The biosensor that will be developed, is based on the on-line monitoring of traction forces that each cells transduce to surfaces through their with the cytoskeleton connected focal adhesion points (FA), being the connecting points between the cell and the material surface. The obtained biosensor can find its application in various fields of health care from characterising specific cells of the patient to optimise the treatment, as biosensor to detect the presence of bioactive medium components having a pharmacological or toxic effect on cells, as a completely new biological tool to describe and investigate time dependent biological processes (fundamental research in the direction of pharma/toxicodynamics, drug effects, effects of gene defects, in combinations with transfected cells genomics, time evolution of subcellular processes, etc.)

CELLNANOTOX • • •

Acronym: CELLNANOTOX Project Title: Cellular Interaction and Toxicology with Engineered Nanoparticles Participants:



Project Abstract: The present proposal aims at the development of innovative multidisciplinary sets of tests and indicators for toxicological profiling of nanoparticles (NPs) as well as unravelling the correlation between the physicochemical characteristics of NPs and their toxic potential on various organs of the human body. For a comprehensive understanding of the complex data to be obtained on toxicology of NPs, based on in-vitro and ex-vivo studies, we will employ conventional toxicology combined with the methodologies of toxicogenomics, metabonomics, Knowledge Discovery from Data (KDD) and Data Mining (DM). This research program is focused towards understanding the relation of size and surface chemistry on the deposition, uptake, translocation, and toxicity of a few selected industrially important NPs as well as novel synthesized NPs, whose size and surface chemistry will be methodically modified. Since it was shown that the penetration of NPs into the human body proceeds principally through inhalation or orally, whereas penetration through healthy skin is restricted, we have chosen lung and intestine as the primary interacting tissues/organs with NPs, while liver, kidney and the immunological system have been selected to be the secondary major sites of interaction, following the penetration of NPs into the blood circulation. The interaction of the NPs with these different target organs will be studied by making use of alternative methods to animal experimentation by employing in-vitro cell systems as well as ex-vivo studies based on precision-cut slices of lung, liver and kidney. The present proposal addresses the needs of the European society for assessing the risk of occupational and general population exposure to industrially manufactured NPs. It will generate new knowledge on potential health risk or the absence of it, providing objective arguments for recommendations and regulations.

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BASF SE (BASF AG), www.basf.com , (DE) COLOROBBIA ITALIA SPA (COLOROBBIA), , (IT) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (COMC-IHC), http://www.jrc.ec.europa.eu , (BE) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (INSERM), www.inserm.fr , (FR) JOHANNES GUTENBERG UNIVERSITAET MAINZ (JGU), www.uni-mainz.de , (DE) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) TP21 GMBH (TP21), www.tp21.de , (DE) WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER (WWU), , (DE)

CELLPROM • • •

Acronym: CELLPROM Project Title: CellPROM - Cell Programming by Nanoscaled Devices Participants: – – – – – – – – – – – – – – – – – – – – – – – – – – –

GESELLSCHAFT FUR ANGEWANDTE MIKRO UND OPTOELEKTRONIK MIT BESCHRANKTERHAFTUNG AMO GMBH* (AMO), www.amo.de , (DE) EUROGENTEC (EGT), www.eurogentec.com , (BE) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) EUROPEAN RESEARCH AND PROJECT OFFICE GMBH (EURICE), www.eurice.de , (DE) EVOTEC TECHNOLOGIES GMBH (EVOTEC), www.evotec-technologies.com , (DE) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FHG/IBMT), www.fraunhofer.de , (DE) GESIM - GESELLSCHAFT FUER SILIZIUM-MIKROSYSTEME MBH (GESIM), www.gesim.de , (DE) GEORG-SPEYER-HAUS - CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT (GSH), www.georg-speyer-haus.de , (DE) INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA (IBET), www.ibet.pt , (PT) LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH (INM), , (DE) GESELLSCHAFT ZUR FOERDERUNG DER ANALYTISCHEN WISSENSCHAFTEN E.V (ISAS), www.isas.de , (DE) KUNGLIGA TEKNISKA HOEGSKOLAN (KTH), www.kth.se , (SE) LEISTER PROCESS TECHNOLOGIES* (LEISTER), www.leister.com , (CH) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPIBPC), www.mpg.de , (DE) INSTITUT PASTEUR (PAS), http://www.pasteur.fr , (FR) SILEX MICROSYSTEMS AB (SILEX), www.silexmicrosystems.com , (SE) SURFACE IMAGING SYSTEMS (S.I.S.) RASTERSONDEN- UND SENSORMESSTECHNIK GMBH (SIS), www.sis-gmbh.com , (DE) SYSMELEC S.A. (SYSMELEC), www.sysmelec.ch , (CH) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) TP21 GMBH (TP21), www.tp21.de , (DE) UNIVERSITAT DE BARCELONA (UB), http://www.ub.es , (ES) TECHNISCHE UNIVERSITAET KAISERSLAUTERN (UNIKL), www.uni-kl.de , (DE) UNIVERZA V LJUBLJANI (UNILJUBL), http://www.uni-lj.si , (SI) UNIVERSITA DEGLI STUDI DI PAVIA (UNIPAVIA), www.unipv.it , (IT) UNIVERSITAET WIEN (UNIVIE), www.univie.ac.at , (AT) VILNIAUS UNIVERSITETAS (UNIVIL), http://www.vu.lt , (LT) UNIVERSITAET DES SAARLANDES (USAAR), www.uni-saarland.de , (DE)

CELLPROM cont. •

Project Abstract: We will develop a new generation of nano-biotechnological equipment, the CellPROMs. As the EPROM paved the way to a broad application of microelectronics, CellPROMs will overcome current limits of and revolutionise the existing handling technologies and procedures by automated, compact and parallel yet still individual handling of large numbers of cellular samples. Typical targets will be animal and human adult stem cells. Human embryonic stem cells will not be used. The main task of our IP is to develop procedures and devices for the precise creation of NanoScapes - individually tailored nanoscaled macromolecular landscapes which will allow, for the first time, to non-invasively produce well-defined populations of individually programmed cells, eventually leading to substantial breakthroughs and numerous applications in the fields of molecular medicine and cellular nano-biotechnology. Although surface imprinting of cells will be realised via artificial nanobiotechnological devices, e.g. nanostructured stamps or beads, these tools are designed according to the natural principles of cellular signalling and differentiation. As nanocomponents are essential to the imprinting process, suitable techniques and principles to form nanoscaled macromolecular patterns on arbitrary surface geometries have to be developed. All components, ranging from the nanoscale of functional interfaces up to the macro level for cell handling, are to be developed as functional modules suitable for further application. The project features multiple nano- and biotechnological challenges. To tackle these, will lead to breakthroughs in nanotechnological device development and, moreover, drastically advance our understanding of biological signals relevant to cellular programming. Once available, CellPROMs will facilitate the transition to a more knowledge-based and less resource-intensive society in Europe.

CIDNA • • •

Acronym: CIDNA Project Title: Control of assembly and charge transport properties of immobilized DNA Participants:



Project Abstract: The goal of this proposal is to establish the basic conditions for DNA-based nano-biotechnology. The programme which rests on biochemistry, advanced co-ordination chemistry, molecular spectroscopy, surface physics and theoretical chemistry comprises: (1)the optimisation of topology and dynamics of surface-immobilised DNA hybrids using a novel spectroscopic approach applying electrochemical and spectroscopic techniques in parallel; (2)the development of novel binding procedures of DNA to metal or semiconductor surfaces; (3)tailored modifications of DNA oligomers and assembly of complex DNA architectures as elements of biosensor devices; (4)high-resolution mapping of the metal/DNA interface; (5)the investigation of intra-hybrid charge transfer based on time-resolved optical spectroscopy; (6)the study of interfacial charge transfer using scanning tunnelling microscopy; (7)an assessment of the mechanism of electron transport in DNA hybrids and across metal/DNA interfaces based on NMR structure and sophisticated molecular modelling simulations The strong impact expected of this joint effort rests on the combination of different synthetic approaches, on the high level of structural resolution, time-resolved electron transport dynamics, topology and electrochemistry of surface-immobilized hybrids of DNA and its analogues and single molecules imaging techniques as well as on quantum chemistry and molecular dynamics simulations. Taken together, this so far unique combination of methods in experiment and theory will yield results crucial for existing and future medical diagnostics and DNA-based environmental biosensorics. In terms of immediate exploitation this CIDNA project will rest on novel robust DNA structures and analogues. In more general terms of DNA-chip technology the programme will also assess the potential of (cheap and fast) electrochemical readout periphery.

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COLLEGE DE FRANCE (CDF), www.college-de-france.fr , (FR) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) EXIQON A/S (EXI), www.exiqon.com , (DK) VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE (ICT), www.vscht.cz , (CZ) USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. (IOCB), http://www.uochb.cas.cz , (CZ) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPI), www.mpg.de , (DE) TECHNISCHE UNIVERSITAET MUENCHEN (TUM), www.tu-muenchen.de , (DE) UNIVERSITAET BASEL (UNIBAS), www.unibas.ch , (CH) SYDDANSK UNIVERSITET (USD), www.sdu.dk , (DK)

COMEPHS • • •

Acronym: COMEPHS Project Title: Controlling Mesoscopic Phase Separation Participants: – – – – – –

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(CAS-BEI-CN), , (CN) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CRISMAT-CAEN-FR), www.cnrs.fr , (FR) INSTITUT ZA FIZIKU (IF-BGD-SER), www.phy.bg.ac.yu , (YU) LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. (IFW-DRE-DE), www.ifw-dresden.de , (DE) INSTITUT JOZEF STEFAN (IJS-LJU-SLO), www.ijs.si , (SI) INSTITUTE FOR THEORETICAL AND APPLIED ELECTROMAGNETICS OF THE RUSSIAN ACADEMY OF SCIENCES ITAE (ITAE-MOS-RU), www.itae.ru , (RU) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPI-STUT-DE), www.mpg.de , (DE) NATIONAL TECHNICAL UNIVERSITY OF ATHENS (NTU-ATH-GR), www.ntua.gr , (EL) UNIVERSITY COLLEGE LONDON (UC-LON-UK), http://www.ucl.ac.uk , (UK) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UNI-CAM-UK), www.cam.ac.uk , (UK) UNIVERSITAET ZU KOELN (UNI-COL-DE), www.uni-koeln.de , (DE) RIJKSUNIVERSITEIT GRONINGEN (UNI-GRO-NL), www.rug.nl , (NL) UNIVERSITAET LEIPZIG (UNI-LEI-DE), http://www.uni-leipzig.de , (DE) UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA (UNI-ROM-IT), www.uniroma1.it , (IT) UNIVERSITAET ZUERICH (UNI-ZUR-CH), http://www.unizh.ch , (CH) UNIVERSITE PARIS-SUD XI (UPS-ORS-FR), www.u-psud.fr , (FR)

Project Abstract: Conventionally, electronic device functions are generated by combining various materials, in which each material has one particular functionality. With the atomic limit as the ultimate achievable goal in sight, we try to explore methods that do not need extensive use of top-down nanotechnology, including lithography and deposition/etching techniques, but use device structures that are spontaneously created by nature in the general framework of electronic phase separation. Here one material can adopt more than one electronic state, and by judicious organization of these electronic states device functions can be generated with built-in atomic precision. In a number of materials like manganites, a spectacularly diverse range of exotic magnetic, electronic and crystal structures can coexist at different locations on the same crystal. What looks in one sense like awkward complexity is in fact a route toward engineering without the difficulties of atomic scale lithography - by manipulating the propensity of phase separation and phase coexistence in these materials we may make dynamically controlled functional electronic structures. The coexisting phases may form robust magnetic, electronic and crystallographic textures on "mesoscopic" length scales. By controlling an array of textured phases analogous to those in liquid crystals we may be able to control locally the electronic structure and properties without atomic-scale fabrication. In manganites, for example, a simple domain wall in the ferromagnetic metallic phase could spontaneously develop an insulating barrier of the charge order phase creating the ultimate spin-tunnel junction. COMEPHS is the first European project that aims to concentrate all necessary resources in Europe in order to achieve functionality of mesoscopic textured states. The research aims to provide basis for a new set of electronic technology and COMEPHS is expected to ensure European preeminence in this strategic domain.

COMETNANO • • •

Acronym: COMETNANO Project Title: Technologies for Synthesis, Recycling and Combustion of Metallic Nanoclusters as Future Transportation Fuels Participants: – – – – –



AEIFOROS METAL PROCESSING S.A. (AEIFOROS), http://www.aeiforos.gr , (EL) Advanced Material Resources (EUROPE) LTD (AMR), , (UK) CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS (CERTH), WWW.CERTH.GR , (EL) CONSIGLIO NAZIONALE DELLE RICERCHE (IM-CNR), www.cnr.it , (IT) POLITECNICA DE VALENCIA (UPVLC), www.upv.es , (ES)

Project Abstract: COMETNANO project is an integrated approach of metallic-nanoparticles synthesis, their controlled combustion in internal combustion engines and regeneration of the respective metal-oxides via reduction by renewable means. The main objectives of COMETNANO project are the following: -The production of tailor-made metal fuel nanoparticles with controllable combustion rate. -The utilization of an environmentalfriendly way for the regeneration of burned particles (oxides), employing 100% renewable hydrogen produced by solar-thermal dissociation of water in coated monolithic reactors. Under such a concept, metal particles become an energy carrier and a means of converting hydrogen-energy into a medium that can be stored and transported easier and safer. -The innovative exploitation of low-cost raw materials, such as discarded fractions/wastes or by-products of metal industries, for the production of the initial metallic nanoparticles. -The introduction of required modifications, based on the existing mature technology of conventional internal combustion engines (ICEs), for the definition of the first metal-fuelled ICE. -The elimination of NOx emissions by proper combustion tuning. -The investigation of potential environmental and health dangers stemming from metallic and oxidic nanoparticles and the introduction of basic protection measurements. The successful completion of COMETNANO project will provide the necessary answers concerning the feasibility and the environmental benefits of such an innovative concept, thus stimulating the interest of both automotive and metal industries. The COMETNANO consortium consists of 5 organizations from 4 E.U. countries, including 2 Industrial partners, 2 Research Institutes and 1 University.

CO-NANOMET • • •

Acronym: CO-NANOMET Project Title: Coordination of NANOMETrology in Europe Participants:



Project Abstract: Nanotechnology has the ability to become the most promising technology advance for the 21st Century. It offers a huge potential of applications and economic benefits, which may contribute to the European economy. Scientifically and economically, nano-metrology is an indispensible part for nanotechnology which must develop hand in hand with the developments of nano-science and –technology. The programme of work set out in this project will address the need within Europe to develop the required measurement frame to successfully support the development and economic exploitation of nanotechnology. A pan-European coordinated response to the emerging needs of nanotechnology defined required from the National Metrology Institutes to provide a suitable measurement framework for the effective commercial development of nanotechnology. To address this requirement a European Strategy Plan for Nanometrology will be delivered in consultation with key stakeholders. 5 European Action Groups in Nanometrology will be implemented to address the need to put in place a process chain for the dissemination of metrology techniques as well as traceability to national standards and internationally harmonised standard methods specific to the particular nanotechnology area addressed. Educational programmes addressing nanometrology across Europe will be reviewed, a future training needs analysis completed and recommendations for training curricula made. Training will be provided in basic nano metrology concepts as well as standardisation. European capabilities review will be completed and a directory published. Exisitng and future requirements for large infrastructures as well as capbility gaps will be assessed. Traceability and metrology in industry will also be addressed. This project will take input from a range of stakeholders including National Metrology Institutes, research institutes, industry, regualtory and standards bodies as well as the EC.

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FUNDACIO PRIVADA ASCAMM (ASCAMM), www.ascamm.es , (ES) CEMMNT HUB LIMITED - THE CENTRE OF EX CELLENCE IN METROLOGY FOR MICRO AND NANO TECHNOLOGIES (CEMMNT), www.cemmnt.co.uk , (UK) DANSK FUNDAMENTAL METROLOGI (DFM), www.dfm.dtu.dk , (DK) EUSPEN - EUROPEAN SOCIETY FOR PRECISION ENGINEERING AND NANOTECHNOLOGY (euspen), www.euspen.eu , (UK) CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI (INSTM), www.instm.it , (IT) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) LABORATOIRE NATIONAL DE METROLOGIE ET D'ESSAIS (LNE), www.lne.fr , (FR) MIDDLE EAST TECHNICAL UNIVERSITY (METU), http://www.metu.edu.tr , (TR) NPL MANAGEMENT LIMITED (NPL), www.npl.co.uk , (UK) PHYSIKALISCH-TECHNISCHE BUNDESANSTALT (PTB), www.ptb.de , (DE) QINETIQ LIMITED (QINETIQ), , (UK) SP SVERIGES TEKNISKA FORSKNINGSINSTITUT AB (SP), www.sp.se , (SE) TECHNISCHE UNIVERSITAET DRESDEN (TUD), , (DE) SOFIISKI UNIVERSITET SVETI KLIMENT OHRIDSKI (UoS), www.uni-sofia.bg , (BG)

CORNEA ENGINEERING • • •

Acronym: CORNEA ENGINEERING Project Title: THREE-DIMENSIONAL RECONSTRUCTION OF HUMAN CORNEAS BY TISSUE ENGINEERING Participants:



Project Abstract: The goal of the proposed research project is to reconstruct a human cornea in vitro, for use both in corneal grafting and as an alternative to animal models for cosmeto-pharmacotoxicity testing. The project responds to the urgent need to develop new forms of corneal replacements as alternatives to the use of donor corneas, in view of of the world-wide shortage of donors, the increasing risk of transmissable diseases, the widespread use of corrective surgery which renders corneas unsuitable for grafting, and the severe limitations of currently available synthetic polymer-based artificial corneas (keratoprostheses). The originality of the proposal lies in the use of recombinant human extracellular matrix proteins to build a nano-engineered scaffold to support growth of the different cell types found in the cornea, cells to be derived from human adult stem cell pools. The development of a reconstructed human cornea will represent a real breakthrough, allowing diseased or damaged corneas to be replaced by tissue-engineered human corneal equivalents that resemble in all respects their natural counterparts. The proposal also responds to impending ED legislation banning the marketing of cosmetic products that have been tested on animals, using procedures such as the Draize rabbit eye irritation test. The development of tissue engineered corneas will provide a non-animal alternative which will therefore alleviate animal suffering. The project will lead to a transformation of industry to meet societal needs using innovative, knowledge-based approaches integrating nanotechnology and biotechnology. The project brings together 14 participants with complementary expertise from 9 different countries, including basic scientists, ophthalmologists and industrialists (three SMEs). Ethical and standardisation aspects will also be included.

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ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP-HTD), www.aphp.fr , (FR) BANQUE FRANCAISE DES YEUX ASSOCIATI ON* (BFY), www.bfy.asso.fr , (FR) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS-DR07), www.cnrs.fr , (FR) FONDAZIONE BANCA DEGLI OCCHI DEL VENETO - O.N.L.U.S. (EBFV), , (IT) BASF BEAUTY CARE SOLUTIONS FRANCE SAS (ENG LYON), www.coletica.fr , (FR) FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR (HSR), www.sanraffaele.org , (IT) LABORATOIRES IOLTECH SA (IOLTECH), www.ioltech.com , (FR) MIDDLE EAST TECHNICAL UNIVERSITY (METU), http://www.metu.edu.tr , (TR) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF (UKE), www.uke.uni-hamburg.de , (DE) UNIVERSITE DE LIEGE (ULG), www.ulg.ac.be , (BE) LUNDS UNIVERSITET (ULUND), www.lu.se , (SE) UNIVERSITY OF DUNDEE (UNIVDUN), www.dundee.ac.uk , (UK) OULUN YLIOPISTO (UOULU), www.oulu.fi , (FI)

DESYGN-IT • • •

Acronym: DESYGN-IT Project Title: DEsign, SYnthesis and Growth of Nanotubes for Industrial Technology Participants: – – – – – – – – – – –

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FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER), www.fraunhofer.de , (DE) INSTITUT JOZEF STEFAN (JSI), www.ijs.si , (SI) LATVIJAS UNIVERSITATE (LU), http://www.lu.lv , (LV) MO6 B.V. (MO6), www.mo6.com , (NL) MITTHOEGSKOLAN (MSU), www.mh.se , (SE) NTERA LTD (NTL), www.ntera.com , (IE) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (NUIC), www.ucc.ie , (IE) QUEEN'S UNIVERSITY BELFAST (QUB), www.qub.ac.uk , (UK) QUEEN MARY AND WESTFIELD COLLEGE, UNIVERSITY OF LONDON (QUEEN MARY), http://www.qmul.ac.uk , (UK) SENSOR TECHNOLOGY AND DEVICES LTD* (ST&D), www.std-ltd.com , (UK) THE PROVOST FELLOWS & SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (TCD), www.tcd.ie , (IE) TOUGHGLASS LTD (TG), www.toughglass.com , (UK) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UCAM-DENG), www.cam.ac.uk , (UK) UNIVERSITY OF ULSTER (UU), www.ulster.ac.uk , (UK)

Project Abstract: The global market for nanotubes (NTs) was worth ?1.4M in 2000, the potential market in 2007 is predicted to reach ?700M. Currently, there is no proven process to manufacture high quality NTs in bulk quantities. Other recognised barriers to industrial take-up include high NT costs (up to ?500/g) and a lack of feasible and affordable applications. The primary Scientific and Technical objective of DESYGN-IT is to establish Europe as the International Scientific Leader in the Design, Synthesis, Growth and Application of nanotubes, nanowires and arrays for industrial technology The project has relevance in applications across several sectors including electronics,mobile applications,diagnostics and high performance composites. DESYGN-IT involves 14 partners, from 6 countries, with complementary leading edge expertise in nanotube, nanowire and array expertise. 3 of the lead researchers have already spun out high-tech companies to exploit research outputs. 2 of the 4 high-tech SMEs partners are nanotech companies. The Technical Programme divides into 4 phases; the 1st is to synthesise a range of NTs and develop processes to scale-up the manufacturing technology. The 2nd phase is to surface engineer the tubes and fill them to form nanowires. In the 3rd phase NT arrays will be grown in a controlled fashion. The 4th and final phase focuses on the development of devices & materials for demonstration to industry and exploitation. DESYGN-IT will deliver -high quality NTs produced in a clean process for industrial use -NTs with defined diameter, chirality and electronic properties for high-tech applications -affordable arrays for device applications -added value products such as high strength materials, sensors to detect bacteria -metallic and semiconductor nanowires for future nanoelectronic applications A well placed European investment in DESYGN-IT will lead to substantial international scientific impact and the desired transformation of industry.

DINAMICS • • •

Acronym: DINAMICS Project Title: DIagnostic NAnotech and MICrotech Sensors Participants:



Project Abstract: DINAMICS aims to promote the uptake of nanotechnological approaches by developing an integrated cost-effective nano-biological sensor for detection of bioterrorism and environmental assays. The prime deliverable is an exploitable lab-on-a-chip device for detection of pathogens in water using on-the-spot recognition and detection based on the nanotechnological assembly of unlabelled DNA. DINAMICS will integrate DNA hybridisation sensors with microfluidics and signal conditioning/processing both on silicon and polymer substrates avoiding the use of external apparatus for fluid handling, electrical signal generation and processing, based on DNA hybridisation. A sensory breakthrough will be achieved trough two complementary technological solutions: Measurements based on electrical (capacitive) signals. If hybridization occurs between target and probe the detected change can be functionalised. Detection through UV light absorption. Based on the recognition of different UV absorptions induced by DNA hybridization. The development of a system where each sensing site in the microarray contains a UV microfabricated sensor is a goal of the project. After DNA hybridization the whole array is illuminated with UV light and the absorption of each site is measured by the sensor. The project will culminate in an integrated multi-technology product that will be high tech, low cost and time efficient sensing device applicable for use in the water industry via the coordination of nano and bio technologies with new sensory science to deliver a product that will lead to major changes in the way the testing and diagnostics of harmful substances is done. Both methodologies will ensure an additional and reliable source of cost-reduction through a drastic shortening of the sensing pipeline and without the need of transferring the samples to an analytical laboratory.





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BHR GROUP LIMITED (BHR), www.bhrgroup.com , (UK) BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM (BME), www.bme.hu , (HU) CRANFIELD UNIVERSITY (CRAN), www.cranfield.ac.uk , (UK) HEMOSOFT BILISIM VE EGITIM HIZMETLERI LIMITED SIRKETI (HEM), www.hemosoft.com , (TR) SPIN OFF INFORMAZIONE DATI ELETTRONICA AUTOMAZIONE SRL (IDEA), , (IT) JP INDUSTRIETECHNOLOGIE UND -ANLAGEN GMBH (JP), www.jp-gmbh.de , (DE) LAMBDA LABOR FUR MOLEKULARBIOLOGISC HE DNA-ANALYSEN GMBH* (LAM), www.lambda.at , (AT) LIONIX BV* (LIONIX), www.lionixbv.nl , (NL) MICROTRONICS ENGINEERING GMBH (MICRO), , (AT) MIKROMIKOMED KFT (MMM), , (HU) PROVENION GMBH (PRO), , (DE) STEINBEIS-STIFTUNG FUER WIRTSCHAFTSFOERDERUNG. (SEZ), www.steinbeis-europa.de , (DE) ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA (UNIBO), www.unibo.it , (IT) VYSKUMNY USTAV VODNEHO HOSPODARSTVA (WRI), www.vuvh.sk , (SK)

DIPNA • • •

Acronym: DIPNA Project Title: Development of an Integrated Platform for Nanoparticle Analysis to verify their possible toxicity and the eco-toxicity. Participants: – –

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UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO (BIONEM), www.unicz.it , (IT) CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE SCIENZE FISICHE DELLA MATERIA (CNISM-UNIMO), http://www.fis.uniroma3.it/cnism/ , (IT) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (COMC-IHC), http://www.jrc.ec.europa.eu , (BE) CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT (CSEM), www.csem.ch , (CH) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER), www.fraunhofer.de , (DE) GRIMM AEROSOL TECHNIK GMBH & CO KG (GRIMM), www.grimm-aerosol.com , (DE) CATALAN INSTITUTE OF NANOTECHNOLOGY (ICN), www.nanocat.org , (ES) PARIS-LODRON-UNIVERSITÄT SALZBURG (USALZ), , (AT) VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V. (VITO NV), www.vito.be , (BE)

Project Abstract: The fast-pacing development of nanosciences and nanotechnologies is due to their great potential in improving the quality of life and in creating novel knowledge-based sustainable processes. This unprecedented "nano-pollution" may in fact pose risks to human (manufacturers and end-users) and animal health that we cannot evaluate at present because of the complete lack of appropriate instruments and bioassays. The DIPNA project aims at creating and validating these instruments and assays, and to propose to the EU and international communities new parameters for detection of nanopollution and evaluation of occupational nanotoxicology, in order to promote prevention and nanosafety in manufacturing and handling. In this novel, multidisciplinary, multinational research project it will be developed a precise knowledge on nano-immunotoxicity, i.e., the impact of nanoparticles and nanopollution in general on human defence cells. This knowledge will be validated in comparison with nano-genotoxicity and nano-carcinogenicity, i.e., studying in parallel the activity of nanoparticles in a standardised transformation assay in vitro, to predict the potential pathological risks of exposure to nanoparticles for human health. The project will be divided in 6 workpackages: 1. Production and physico-chemical characterisation of nanoparticles; 2. Evaluation of NP interaction with human defence cells: selection of representative cell systems; 3. Evaluation of one-to-one NP-cell interaction: definition of threshold and dose-dependent effects; 4. Evaluation of chronic and repeated exposure: eco-nanotoxicity; 5. Field validation and development platform; 6. Coordination, management, training, and public awareness. The scientific knowledge gained during this project will provide the ground for a development platform, aiming at standardising and field-validating prototypic assays and related instruments for biodetection of nanoparticle-associated health risks.

DREAMS • •

Acronym: DREAMS Project Title: DIAMOND to RETINA ARTIFICIAL MICRO-INTERFACE STRUCTURES



Participants: – – – – –



COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) FORSCHUNGSZENTRUM JUELICH GMBH (FZJ), www.fz-juelich.de , (DE) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (INSERM), www.inserm.fr , (FR) TECHNISCHE UNIVERSITAET MUENCHEN (TUM), www.tu-muenchen.de , (DE) UNIVERSITY COLLEGE LONDON (UCL), http://www.ucl.ac.uk , (UK)

Project Abstract: Electrical stimulation of neurons is a recognised therapeutic approach for the treatment of neurodegenerative pathologies (Parkinson disease etc). These techniques could have a high impact on treatments of other pathologies like epilepsy or blindness. Available commercial devices based on metalised electrodes degrade in physiological environments and induce reactive gliosis, incompatible with fabrication of implants, where a long term stability is mandatory and a closer neuro-electronic interface is required to lower the neuronal activation threshold. The high resolution required for vision and the stimulation of graded potential neurons need complex and very precise stimulators. DREAMS propose to study andfabricate novel types of nanotransducers, based on artificial nanocrystalline diamond (NCD), that exhibits extreme biocompatibility and stability in physiological media. NCD coated and functionalised metallic electrodes or non metalised CMOS devices will be fabricated, leading to novel active neural cell-hybrid structures and biocompatible implants to restore a useful vision. Survival of neurons and retinal cells will be evaluated and in-vitro stability and the ability to activate neurones will be tested. DREAMS will lead to the fabrication of matrixes of Field Effect Transistors that can be validated for stimulation of the retina as well as for readout of the retinal signals in-vivo.

DYNASYNC • • •

Acronym: DYNASYNC Project Title: Dynamics in Nano-scale Materials Studied with Synchrotron Radiation Participants: – – – –

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STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY (DESY), www.desy.de , (DE) INSTALLATION EUROPEENNE DE RAYONNEMENT SYNCHROTRON (ESRF), www.esrf.fr , (FR) INSTYTUT KATALIZY I FIZYKOCHEMII POWIERZCHNI, POLSKA AKADEMIA NAUK (ICSC), http://www.ik-pan.krakow.pl , (PL) THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS, POLISH ACADEMY OF SCIENCES (INP), www.ifj.edu.pl , (PL) KATHOLIEKE UNIVERSITEIT LEUVEN (K.U.LEUVEN), www.kuleuven.be , (BE) MTA KFKI RESZECKE-ES MAGFIZIKAI KUTTATIONTEZET (KFKI RMKI), www.rmki.kfki.hu , (HU) UNIVERSITAET WIEN (UW), www.univie.ac.at , (AT)

Project Abstract: The dynamical effects are expected to govern the function and performance of future nanoscale devices and it is extremely important to develop efficient methods for their characterization. The study of dynamics in nanostructures requires a special methodology, both for modelling and for the experiment. Nuclear resonant scattering (NRS) of synchrotron radiation, which has gained in recent years the sensitivity required to study ultra thin films, surfaces and nanostructures, combines the possibility of exploring nearly the whole field of the dynamical effects. The aim of the present project is an interdisciplinary study of different dynamical aspects: (i) diffusion, (ii) phonons and (iii) magnetization dynamics on carefully selected modelnanostructures, to understand the size dependence and interplay between different excitations, using a variety of experimental methods among which NRS plays the primary role. The project will require the development of experimental tools and methodologies related to experiments using the European Synchrotron Radiation Facility in Grenoble. The consortium is composed of partners with respectable synchrotron experience combined with the expertise in the research fields involved in the scope of the project. Besides the scientific and technical objectives there are quite substantial socio-economic and policy objectives. Here we not only build up a consortium from EC member countries but strongly aim to the participation and even for a leading role of the new member countries. This synergy will also allow for economic savings and will result in a common exploitation of the excellent skills and knowledge of scientists from EC and new member countries.

EMBEK1 • • •

Acronym: EMBEK1 Project Title: Development and analysis of polymer based multi-functional bactericidal materials Participants:



Project Abstract: 90% of bacteria are found attached to solid surfaces forming structures (bio-films), that are inaccessible to drugs and antibiotics. These bio-films represent a major problem in European society in both industry and health care. Currently, however, we understand little about how these bio-films form and, more importantly, how they can be prevented. This lack of understanding means that patients often suffer ‘unnecessary’ and painful infections following the formation of such films on surgical implants and catheters. With the growing problem of MRSA and C. difficile in hospitals, and the cost of policing and hygiene measures, an understanding of how to prevent bacterial persistence in the hospital environment is critical to the sustainability of European healthcare. A multi-disciplinary group of European experts have the common aim to understand exactly how bacteria attach to, and persist on both biological and inert surfaces. We will use a range of biological and physio-chemical techniques to study several fundamental aspects of bacterial attachment. We will employ new molecular microbiology techniques to understand the genetic components governing the interaction of a bacterial biotic cell surface with the novel antimicrobial surfaces we create. Second, we will be using new nano-scale material science and physical chemistry techniques to create and understand these antimicrobial surfaces. This duel systems approach will allow us to theoretically model the processes of bacterial attachment and survival, which in turn will allow us to improve these surfaces in an iterative approach. We will generate intellectual property around the coatings and treatments used to derive the surfaces and develop these in collaboration with industry. The solutions will be designed specifically for the industrial partners participating in the project but can, with a minimum effort be adapted for applications in other areas through the iterative steps within the WPs.

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UNIVERSITY OF BATH (Bath), , (UK) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) JOHANNES GUTENBERG UNIVERSITAET MAINZ (JOGU), www.uni-mainz.de , (DE) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) NPL MANAGEMENT LIMITED (NPL), www.npl.co.uk , (UK) ROCHE DIAGNOSTICS GMBH (Roche), www.roche-diagnostics.com , (DE) SEFAR AG (Sefar), , (CH) KLINIKUM DER UNIVERSITAET ZU KOELN (UKK), www.kppk.de , (DE) THE UNIVERSITY OF EXETER (UNEXE), www.ex.ac.uk , (UK)

ENF 2003 • • •

Acronym: ENF 2003 Project Title: EuroNanoForum 2003 Participants: –



BIC - SVILUPPO ITALIA FRIULI VENEZI A GIULIA SPA* (SI FVG), www.sviluppoitalia.it , (IT)

Project Abstract: EuroNanoForum 2003 (ENF 2003), the European and international nanotechnology Forum promoted by DG Research, Directorate G, distinguishes itself because of its integrated and interdisciplinary approach, as well as because of its global relevance and scope. To achieve the integration characteristic, the program has been structured so to allow an interchange of information, ideas, best practices and discussions not only among scientists, but also with business people, investors, policymakers, educators, experts in communication and international co-operation. The Forum will be the catalyst and facilitator event to set up relations and co-operative ties - on a global geographical scale - between research, technology transfer institutions, larger companies and SMEs, to facilitate nanotechnology development and to initiate a process leading to the identification of approaches, co-operation programmes, tools and infrastructure facilities which will accelerate scientific development and innovation on the marketplace. Besides the European-level objectives of DG Research, in line with those of the ERA, the international dimension and the integrating character of the 6th Framework Programme, the expected outcome of EuroNanoForum 2003 will be to help strengthen the supportive role of the Friuli Venezia Giulia and neighbouring regions as platform supporting networks linking scientists, providers of business and entrepreneurial-support services, venture capital etc. which will contribute to accelerate the advance of nanotechnology in Central and Eastern Europe. The Forum will thus help launch the concept of an immaterial "Hi-Tech Corridor" supporting economic development and investment in these regions. To this end, the tasks and. activities that will be undertaken by the Project Co-ordinator - Sviluppo Italia Friuli Venezia Giulia - will be implemented in close co-operation with Local Partners, as well as International and National Partners.

ENF 2005 • • •

Acronym: ENF 2005 Project Title: EuroNanoForum2005 - 'Nanotechnology and the Health of the EU Citizen in 2020' Participants:



Project Abstract: This SSA is for support for a 5-day conference on the theme 'Nanotechnology and the Health of the EU Citizen in 2020' from 5-9 September 2005 in Edinburgh. It is being organized by The Institute of Nanotechnology. It will build on the success of EuroNanoForum2003, and promote developments in nanotechnology that are leading to innovative solutions for health and healthcare in Europe as part of an integrated and responsible approach. The format will be a combination of thematic workshops, public debate, forums, and conference showing the state-of-the-art. EuroNanoForum2005 is forming a prestigious element of the UK's 6th Presidency of the EU, which runs from June to December 2005. It will also be timely in terms of reinforcing the EU policy for research funding fo nanotechnology and converging technologies in the Seventh Framework Programme. EuroNanoForum2005 will explore several critical issues, such as the ongoing competitiveness of the European healthcare industries; meeting the demands of an ageing population, the early diagnosis and potential cures, for example, of cancer, cardiovascular disease and inflammatory diseases. It aims to demonstrate the potential of nanotechnologies to address these issues, support the creation of high quality jobs, and underpin important EU objectives such as the Lisbon Agenda. To achieve its aim, EuroNanoForum2005 will promote exchanges on groundbreaking European research in nanotechnologies as applied to healthcare, bringing together key industrial players, academia, and policy makers, in an international context. Key themes include: - A review of EU research progress since 2003 - A look to FP7, and the role of convergent technologies in the EU strategy for healthcare - New developments in tissue engineering; targeted drug delivery; biomaterials; analytical, imaging and sensing techniques - How ethical, environmental, social, safety & risk concerns are being addressed - Nanomedicine for the developing countries



INSTITUTE OF NANOTECHNOLOGY (ION), www.nano.org.uk , (UK)

ENF 2007 • • •

Acronym: ENF 2007 Project Title: Organization of the Conference EURONANOFORUM 2007 - Nanotechnology in Industrial Applications Participants: –



VDI TECHNOLOGIEZENTRUM GMBH (VDI TZ), www.vditz.de , (DE)

Project Abstract: Nanotechnology is one of the most promising cross-section technologies and can be understood as an important key technology of the 21 century. It helps to improve products and production processes with better characteristics or new functionalities. In the upcoming years nanotechnology will impact nearly all industrial sectors and enter consumer markets in large quantities. The intended EuroNanoForum 2007 will be organized as a 3- day conference, taking place from June 19 to 21, 2007 at the Conference Center Duesseldorf within the German presidency. The conference will be established as the foremost European congress for the transfer of nanotechnology from research into industrial production processes, products and applications. It brings together excellent scientists with leading researchers and managers from industry. The comprehensive conference programme will present the current state of nanotechnology for industrial applications and open up new perspectives for Europe in the coming years. The conference is focused on Nanotechnology in industrial applications and will contribute to: - A successful development of European nanotechnology through the exchange of knowledge between participants from all European countries with representatives from industry, research, finance; - Finding ideas to transform the results of nanotechnology research into new products and profit for European industry; - Show the state of the art of European nanotechnology products and components for different applications Besides the sessions an accompanying poster exhibition and an industrial exhibition is planned. The accompanying industrial exhibition shall demonstrate the state of the art of industrial implementation of technical knowledge into industrial products.

ENF 2009 • •

Acronym: ENF 2009 Project Title: Organization of the Conference EURONANOFORUM 2009 "Nanotechnology for Sustainable Economy"



Participants: –



TECHNOLOGICKE CENTRUM AKADEMIE VED CESKE REPUBLIKY (TC AV CR), www.tc.cz , (CZ)

Project Abstract: The conference EuroNanoForum 2009 will be established as a foremost European congress in Nanotechnology within the framework of the Czech presidency. The conference will address the impact of nanotechnologies on sustainable economy focusing on their applications in resource- and eco-efficient industrial production, environmental protection and remediation, and energy production and conservation in the coming years. It aims to: (i) present the nanotechnology state of the art in the realm of sustainable economy;(ii) facilitate intensive exchange of views, information and experience between researches and representatives of industry, investors as well as policy makers and representatives of civil society; (iii) foster networking and knowledge transfer between different national and European stakeholders; and (iv) promote responsible governance in nanotechnology.

ENNSATOX • • •

Acronym: ENNSATOX Project Title: Engineered Nanoparticle Impact on Aquatic Environments: Structure, Activity and Toxicology Participants:



Project Abstract: The use of engineered nanoparticles in cosmetics, pharmaceuticals, sensors and many other commercial applications has been growing exponentially over the past decade. EU and Member State’s research into the environmental impact of these materials, particularly in aquatic systems, is at an early stage. ENNSATOX addresses this deficit through a, comprehensive investigation relating the structure and functionality of well characterised engineered nanoparticles to their biological activity in environmental aquatic systems. An integrated approach will assess the activity of the particles in a series of biological models of increasing complexity. Parallel environmental studies will take place on the behaviour of the nanoparticles in natural waters and how they modify the particles' chemical reactivity, physical form and biological activity. An integrated theoretical model will be developed describing the environmental system as a series of biological compartments where particles transport between a) compartments by advection-diffusion and b) between phases by a transfer function. Following optimisation of the transfer functions a generic predictive model will be derived for the environmental impact of each class of nanoparticle in aqueous systems. A generalised understanding of the dependence of the nanoparticle biological activity on its structure and functionality will be obtained including the role and interaction of the biological membranes within organisms. ENNSATOX will generate: 1) exploitable IP (devices and ecotoxicology predictive software package); 2) set of standard protocols for assay of nanoparticle biological activity which can be later accredited; 3) global dissemination of results; 4) creation of an EU laboratory service; 5) tools and data to inform EU Regulation and the EC’s code of conduct for responsible nanosciences and nanotechnologies research, ftp://ftp.cordis.europa.eu/pub/nanotechnology/docs/nanocode-recommendationpe0894c08424_en.pdf.

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MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM (MBA), www.mba.ac.uk , (UK) Society of Environmental Toxicology and Chemistry - Europe VZW (SETAC Europe), www.setac.org , (BE) STAZIONE ZOOLOGICA ANTON DOHRN (SZN), www.szn.it , (IT) UNIVERSITEIT ANTWERPEN (UA), www.ua.ac.be , (BE) DE LLEIDA (UdL), www.udl.cat , (ES) UNIVERSITY OF LEEDS (UNIVLEEDS), www.leeds.ac.uk , (UK) WAGENINGEN UNIVERSITEIT (WU), http://www.wageningenuniversiteit.nl/UK/ , (NL)

ENPRA • • •

Acronym: ENPRA Project Title: RISK ASSESSMENT OF ENGINEERED NANOPARTICLES Participants: – – – –

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VRIJE UNIVERSITEIT BRUSSEL (Brussel), www.vub.ac.be , (BE) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) DUKE UNIVERSITY (Duke), www.duke.edu , (US) HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH (HMUG), www.helmholtzmuenchen.de , (DE) INSTITUTE OF OCCUPATIONAL MEDICINE (IOM), www.iom-world.org , (UK) INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH (IUF), www.iuf.uniduesseldorf.de , (DE) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) KATHOLIEKE UNIVERSITEIT LEUVEN (K.U.Leuven), www.kuleuven.be , (BE) EDINBURGH NAPIER UNIVERSITY (Napier), www.napier.ac.uk , (UK) DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO (NRCWE), www.nrcwe.dk , (DK) UNIVERSITE PARIS DIDEROT - PARIS 7 (Paris VII), www.univ-paris-diderot.fr , (FR) RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (RIVM), www.rivm.nl , (NL) UNIVERSITY OF ROCHESTER (Rochester), www.urmc.rochester.edu , (US) UNIVERSITE CATHOLIQUE DE LOUVAIN (UCL), www.uclouvain.be , (BE) Københavns Universitet (UCPH), www.ku.dk , (DK) THE UNIVERSITY OF EDINBURGH (UEDIN), www.ed.ac.uk , (UK) UNIVERSITA CA' FOSCARI DI VENEZIA (Venice), www.unive.it , (IT)

Project Abstract: Engineered Nanoparticles (ENP) are increasingly produced for use in a wide range of industrial and consumer products. Yet it is known that exposure to some types of particles can cause severe health effects. Therefore it is essential to ascertain whether exposure to ENP can lead to possible health risks for workers and consumers. We have formed a consortium of well-known scientists from European Universities and Research Institutes, with over 100 publications in the field of Nanotoxicology. Our aim is to develop an approach for the Risk Assessment of ENP (ENPRA). Our objectives are: (i) to obtain a bank of commercial ENP with contrasting physicochemical characteristics and measure them; (ii) to investigate the toxic effects of ENP on 5 (pulmonary, hepatic, renal, cardiovascular and developmental) target systems and 5 endpoints (oxidative stress, inflammation; immuno-toxicity; fibrogenecity; genotoxicity) using in vitro animal/human models; (iii) to validate the in vitro findings with a small set of carefully chosen in vivo animal experiments; (iv) to construct mathematical models to extrapolate the exposure-dose-response relationship from in vitro to in vivo and to humans; (v) to use QSAR like models to identify the key ENP characteristics driving the adverse effects; (vi) to implement a risk assessment of ENP using the Weight-of-Evidence approach; (vii) to disseminate our findings to potential stakeholders. To harmonise the research activities between our EU group and the US, we have established links with scientists from US Universities (Duke, Rochester) and Government Agencies (NIH/NIEHS, NIOSH and EPA) with on-going research in Nanotoxicology. Our objectives here are (vii) to share information and agree on experimental protocols; (viii) to avoid duplication of work; (ix) to further validate the findings of this proposed study.

ENRHES • • •

Acronym: ENRHES Project Title: Engineered Nanoparticles: Review of Health and Environmental Safety Participants: – – – – –



DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) INSTITUTE OF OCCUPATIONAL MEDICINE (IOM), www.iom-world.org , (UK) INSTITUTE OF NANOTECHNOLOGY (IoNano), www.nano.org.uk , (UK) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) EDINBURGH NAPIER UNIVERSITY (NAPIER), www.napier.ac.uk , (UK)

Project Abstract: The overall aim of the ENRHES project is to perform a comprehensive scientific review of the health and environmental safety of fullerenes, CNTs, metal and metal oxide nanomaterials. The review will consider sources, pathways of exposure, the health and environmental outcomes of concern, in the context informing the regulation of the potential risks of engineered nanoparticles. We will employ a standardised information management strategy and a matrix approach to maximise the gain to partners and beneficiaries involved with the review. The specific objectives will be to review information on: § production, use and exposure to the target engineered nanomaterials § persistence, bioaccumulation and interactions of the engineered nanoparticles in living & environmental systems; § differences in toxicity posed by variations in size, type and chemical composition. On the basis of the review, prioritised recommendations on each of the above points will be developed and set in the context of informing policy makers in the development of methods to address exposure as it relates to the potential hazards posed by engineered nanoparticles, and in the development of appropriate regulation.

ENSEMBLE • • •



Acronym: ENSEMBLE Project Title: ENgineered SElf-organized Multi-component structures with novel controllaBLe Electromagnetic functionalities Participants: – – – – – – – –

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (FORTH), www.forth.gr , (EL) DE ZARAGOZA (ICMA), http://i3a.unizar.es/eng/index_eng.php , (ES) FORSCHUNGSVERBUND BERLIN E.V. (IKZ), www.fv-berlin.de , (DE) INSTYTUT TECHNOLOGII MATERIALOW ELEKTRONICZNYCH (ITME), www.itme.edu.pl , (PL) SZILARDTESTFIZIKAI ES OPTIKAI KUTATOINTEZETE - MAGYAR TUDOMANYOS AKADEMIA (RISSPO), www.szfki.hu , (HU) BRUNEL UNIVERSITY (UBRUN), www.brunel.ac.uk , (UK) UNIVERSITY OF SOUTHAMPTON (UoS), http://www.southampton.ac.uk , (UK)

Project Abstract: Growth of eutectics is recognized as a paradigm for pattern-forming. Self-organised structures of size scales reaching down to submicron and nano scale regime emerge due to the interplay of chemical diffusion and capillarity. The fundamentally novel CONCEPT of the present proposal is to utilize - for the first time - the eutectic self-organisation mechanism for preparation of multi-component and multi-scale structures with controlled physicochemical and structural properties, with geometrical motifs capable of generating novel, predictable and controllable electromagnetic functionalities. This requires a deeper understanding of factors influencing eutectic self-organisation mechanism on a submicron/nanoscale. Accordingly, the main topic and activity of the present proposal is to generate new knowledge of the mechanism of eutectic self-organisation on this scale, by combining state-of-the-art experimental and modelling techniques. This new understanding of the underlying processes of eutectic self-organisation will then be used for the prediction and design of self-organised multi-component and multi-scale structures with controlled physicochemical and structural properties. This will be combined with the electromagnetic design of complex structures which can generate revolutionary electromagnetic functionalities. This will result in: a) the ability to predict the occurrence of patterns in eutectic systems, b) knowledge on how to design nanopatterned materials with controlled physicochemical and structural properties, c) methodologies to design and to fabricate self-organised multi-component and multi-scale structures with revolutionary electromagnetic functionalities, and d) the experimental realisation of these self-organised systems. The planned research is expected to open new horizons for utilizing self-organised structures in the development of the next generation of materials for photonic application that will exhibit revolutionary properties.

EURONANOBIO • • •

Acronym: EURONANOBIO Project Title: EUROpean scale infrastructure in NANOBIOtechnology Participants: – – – – – – –



GESELLSCHAFT FUR BIOANALYTIK MUNSTER EV (BioMS), www.bioanalytik-muenster.de , (DE) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) FONDAZIONE DON CARLO GNOCCHI ONLUS (FDG), www.dongnocchi.it , (IT) FUNDACIÓ PRIVADA INSTITUT DE BIOENGINYERIA DE CATALUNYA (IBEC), www.ibecbarcelona.eu , (ES) INSTITUTUL NATIONAL DE CERCETAREDEZVOLTARE PENTRU MICROTEHNOLOGIE (IMT), www.imt.ro , (RO) UNIVERSITEIT TWENTE (Mesa+), www.utwente.nl , (NL) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (TNI-UCC), www.ucc.ie , (IE)

Project Abstract: EuroNanoBio aims at defining the key features of the future EU capacity in nanobiotechnology and the roadmap to reach this goal. It will establish the features of the infrastructure, the role of the various stakeholders and the way to establish it. This Support Action is divided into three phases: 1) An analytical phase where the existing data, published or not, will be scrutinised and analysed to extract some success factors to be used for defining the EU infrastructure in nanobiotechnology. This analysis is conducted in four directions • existing top class infrastructures or clusters inside and outside Europe • modes of technology transfer from research to industry • multidisciplinary education and training • ancillary aspects of nanobiotechnology. 2) A building and consensus phase where many diverse stakeholders who play a role in the EU capacity in nanobiotechnology are invited to jointly defined and adopt the key features of the infrastructure, and the way to build it 3) A dissemination phase where the former results will be widely disseminated using Internet and a large dissemination event. The EuroNanoBio partners are highly experienced in EU integration in nanobiotechnology in general as well as in specific aspects studied in the CSA. They have unrivalled access to a wide panel of stakeholders in governments, industry, education, regulation, ethics. The consortium will act as a catalyst for these stakeholders to collect their contribution and make them build together the roadmap for establishing the EU capacity in nanobiotechnology.

EXCELL • • •

Acronym: EXCELL Project Title: Exploring Cellular Dynamics at Nanoscale Participants:



Project Abstract: EXCELL is a novel innovative approach to explore interaction mechanisms between biological materials and systems/nanostructures. It involves a forward-looking cross-disciplinary and design-based research to generate an integrated, biologically inspired technological platform of high complexity, able to monitor cell dynamics at nano-scale. Expertise in cellular and molecular biology, nanosciences, material engineering, biophysics, biotechnology, modelling, and analytical chemistry, are combined to address the targeted goals, which go beyond the state of the art methods used in traditional biotechnology and systems biology. EXCELL will provide a complete Lab-in-a-Cell (LIC) sensor and actuator platform, which is capable of: (1) studying single cells in their natural environment surrounded by other cells or a complex mixture of different cells/tissue, (2) following the dynamics and interdependence of single cell processes from gene, protein, metabolite to compound secretion, exocytosis and cell-to-cell communication, (3) testing how and where various stimuli affect the different levels of the molecular machinery and finally (4) programming cells to be able to differentiate into a particular phenotype. A major task is the design of suitable biocompatible nano/bio interfaces that ensures a sustainable cellular environment. EXCELL provides a unique opportunity for developing advanced, novel experimental tools to address fundamental problems of stem cell research and poses a potential for possible diversification and modulation of developmental programs of stem cells to differentiate them into specific phenotypes. EXCELL has the capacity to drive new discoveries having a significant impact not only in the field of stem cell research and clinical use, but also on molecular engineering, nanosciences, sensor development, diagnostics, therapeutics, biotechnology and industry (smart materials, medical diagnostics, pharmaceutical companies, start-ups)

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CHEMICAL RESEARCH CENTER OF THE HUNGARIAN ACADEMY OF SCIENCES (CRC-HAS), www.chemres.hu , (HU) DANMARKS TEKNISKE UNIVERSITET (DTU Nanotech), www.dtu.dk , (DK) LUXCEL BIOSCIENCES LTD (LUXCEL), www.luxcel.com , (IE) POLITECNICO DI MILANO (POLIMI), , (IT) SCITECH LINK HB (STL), , (SE) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) AUTONOMA DE MADRID (UAM), http://www.uam.es , (ES) UNIVERSITA DEGLI STUDI DI GENOVA (UGDIBE), www.unige.it , (IT) LUNDS UNIVERSITET (ULUND), www.lu.se , (SE) UNIVERSITAET POTSDAM (UP), www.uni-potsdam.de , (DE)

FIBLYS • • •

Acronym: FIBLYS Project Title: Multi-functional Analytical Focussed ion beam tool for nanotechnology Participants:



Project Abstract: The project FIBLYS aims at developing an innovative nanostructuring, nanomanipulation and nanoanalysis instrument: a hybrid scanning probe (SPM) and dual beam focussed ion beam (FIB) instrument (including scanning electron microscopy (SEM) capabilities). In addition to an instrument based on conventional dual beam FIB(SEM) technology, an SPM/FIB(SEM) microscope will use both techniques, integrated in a compact setup offering capabilities that not only combine the techniques but allow for nanoanalysis and nanostructuring/manipulation options that the single instrument or sequential use of the techniques is unable to achieve. This FIBLYS hybrid device will allow to use all FIB capabilities while imaging the procedures with the integrated SEM. The SEM has the options of chemical analysis through Energy Dispersive X-ray analysis (EDX) and structural analysis through Electron Backscatter diffraction (EBSD). The combination of SEM and SPM provides for the combination of nano-scale chemistry and crystallography imaging via electron-matter interactions (EDX, EBSD) with the information from tip-sample interactions like topography or magnetic/electrostatic force imaging. Combining electron-matter and tip-sample interactions, the FIBLYS hybrid instrument will for the first time allow to probe with nano-scale resolution many electron-matter interactions like detection of electron beam induced current (EBIC), or cathodoluminescence or phonons, or backscattered electrons directly at the surface with cantilever based sensors. This project will merge FIB(SEM) and SPM manufacturers at European level and reinforce their competitiveness. The partnership reflects the excellence and competences needed in this project, only possible through transnational co-operative research of six SMEs (SPM and FI(SEM) manufacturers, specialists in SPM and SEM control, expertise in electron/ion optics, cantilever manufacturers for SPM techniques as well as three RTD performers.

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CARL VON OSSIETZKY UNIVERSITAET OLDENBURG (AMiR), , (DE) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V (IPHT), www.ipht-jena.de , (DE) UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE (LMEN), http://www.univ-reims.fr/ , (FR) OFFIS E.V. (OFFIS), WWW.OFFIS.DE , (DE) SMARACT GMBH (SMRCT), www.smaract.de , (DE) TESCAN SRO (TESCAN), , (CZ) TOFWERK AG (TOFWERK), www.tofwerk.com , (CH)

FIND AND BIND • • •

Acronym: FIND AND BIND Project Title: Find and Bind: Mastering sweet cell-instructive biosystems by copycat nano-interaction of cells with natural surfaces for biotechnological applications Participants: – – – –

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CHALMERS TEKNISKA HOEGSKOLA AB (Chalmers), www.chalmers.se , (SE) Eidgenössische Technische Hochschule Zürich (ETHZ), www.ethz.ch , (CH) Histocell S.L. (Histocell), www.histocell.com , (ES) VEREIN ZUR FORDERUNG VON INNOVATIONEN DURCH FORSCHUNG ENTWICKLUNG UNDTECHNOLOGIETRANSFER EV (INNOVENT), www.innovent-jena.de , (DE) MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG (MLU Halle), http://www.uni-halle.de , (DE) Q-Sense AB (Q-Sense), www.q-sense.com , (SE) Stemmatters, Biotecnologia e Medicina Regenerativa Lda (StemMatters), www.stemmatters.com , (PT) FUNDACION TEKNIKER (TEKNIKER), www.tekniker.es , (ES) E DO MINHO (UMINHO), www.uminho.pt , (PT)

Project Abstract: Living cells are complex entities with remarkable capacity to sense, integrate and respond to environmental cues. The term directional sensing refers to the ability of a cell to determine the direction and proximity of an extracellular stimulus and to convert this information into biochemical signals. So far, the mechanisms of this extremely complex process are to be elucidated. Undoubtedly, carbohydrates are a class of molecules which together with the proteins span a large spectrum of these mechanisms: from those that are trivial to those that are crucial for the development, growth, function or survival of an organism. Find and Bind aims to explore the potential of this class of molecules to mediate specific recognition events and therefore to provide modulation of biological processes. Approaching and employing the nanoscale mechanisms of the interactions of cells and their physiological milieu Find and Bind will create biological design criteria for the development of new materials and devices constructed from these materials. Taking the cell-matrix adhesion to the third dimension by re-creating both signals and timing of natural occurring events will be applied to develop third generation polysaccharide based constructs. Combining nanostructured scaffolds from naturally derived polymers and the incorporation of biological signals will provide inherent informational guidance in recreating cell-cell interactions and control tissue formation in vitro and in vivo. The long-term innovation potential of the developed constructs as (i) 3D cell instructive materials able to restore and enhance the functions of healthy tissues; (ii) Biosensors and (iii) Surfaces for selective differentiation of stem cells will also be in the targets of this proposal.

FORCETOOL • • •



Acronym: FORCETOOL Project Title: Multipurpose Force Tool for Quantitative Nanoscale Analysis and Manipulation of Biomolecular, Polymeric and Heterogeneous Materials Participants: – – – – – – – – –

CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) TECHNISCHE UNIVERSITAET CHEMNITZ (CUT), http://www.tu-chemnitz.de , (DE) ELDISA SL (ELDISA S.L.), , (ES) UNIVERSITAET LINZ (JKU), , (AT) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMU), www.uni-muenchen.de , (DE) NANOWORLD SERVICES GMBH (NANOWORLD), www.nanoworld.com , (DE) AUTONOMA DE MADRID (UAM), http://www.uam.es , (ES) UNIVERSITEIT TWENTE (UT), www.utwente.nl , (NL)

Project Abstract: FORCETOOL (FT) proposes to develop a multipurpose tool for quantitative nanoscale analysis and manipulation of biomolecular, polymeric and heterogeneous surfaces. Key features of the proposed instrument are 1 nm spatial resolution and 1 pN force sensitivity; operation in technological relevant environments (air or liquids) and with no impact on the sample surface.The multifunctionality and flexibility of FT will enable characterization, control or manipulation of structures on a nanometer-scale, so it will open new approaches for manufacturing at molecular and nanoscale levels. This tool is based on two innovative concepts : (i) the bimodal AFM and (ii) the multimaterial methodolody. The bi-modal AFM concept considers the cantilever as a three dimensional object with several resonance modes, in particular two. The concept departs radically from the established principles of dynamic force microscopy (only the fundamental mode is considered). The double excitation allows to separate topography from composition contributions in the experimental data. Furthermore, the bi-modal AFM is about two orders of magnitude more sensitive to force variations than state of the art tapping mode AFMs. The multimaterial methodology will allow to transform the amplitude, frequency or phase shift changes measured by the instrument into quantitative information about the sample properties. The multimaterial methodology has both a general framework to describe dynamic force microscopy interactions and specific codes to be used with different materials such as inorganic materials, biomolecules , polymers or molecular architectures. Specific key goals are: Topography, composition analysis and manipulation of biomolecules, polymers and heterogeneous surfaces; operation in air or liquids environments; 1 nm spatial resolution and 1 pN force sensitivity; compatibility with existing atomic force microscopes

FRONTIERS • • •



Acronym: FRONTIERS Project Title: NoE Research and facilities directed at instrumentation for manufacturing and analysis of single molecules and individual nanoclusters, targeted at life sciences Participants: – – – – – – – – – – – –

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CEMES-CNRS), www.cnrs.fr , (FR) CENTECH GMBH (CENTECH), www.centech.de , (DE) CHALMERS TEKNISKA HOEGSKOLA AB (CHALMERS), www.chalmers.se , (SE) FORSCHUNGSZENTRUM KARLSRUHE GMBH (FZK), www.fzk.de , (DE) INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW (IMEC), www.imec.be , (BE) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPI FKF), www.mpg.de , (DE) UNIVERSITAET BASEL (NCCR), www.unibas.ch , (CH) TECHNISCHE UNIVERSITEIT DELFT (TUDELFT), www.tudelft.nl , (NL) AARHUS UNIVERSITET (UAAR), www.au.dk , (DK) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UCAM DENG), www.cam.ac.uk , (UK) UNIVERSITEIT TWENTE (UT), www.utwente.nl , (NL) WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER (WWU), , (DE)

Project Abstract: Frontiers' aim is to provide Europe with a leading position in life sciences related nanotechnology within 4 years. In Frontiers there is a focus on analysis and manipulation of the bio environment. We will use the experience of the consortium in technology to create novel systems and our mutual interaction to conceptualise and design them. Frontiers creates centres of excellence in science as well as facilities. Partners concentrate more on focused, 'core areas', spend less effort on R&D/facilities outside these 'core areas'. Main elements of Frontiers are aimed at increasing the research efficiency, the infrastructural efficiency, the education efficiency and at building more and better business cases. The Joint Program of Activities (JPA) is grouped in 4 blocks: • Coordination of research, leading to a Joint Research Programme; • Implementation of a 'Virtual European Nanosciences Laboratory', to ensure efficient use of infrastructure as well as the availability of equipment for the researchers; • Creation of an integrated European Joint Curriculum on life sciences related nanotechnology; • Spreading of Excellence, with a focus on joint IPR management and on the development of new business cases (Science-to-Industry). Basics of the Frontiers consortium: individual excellence in science, excellent nanotechnology infrastructure, proven capability to initiate start-ups, outstanding relations with nanotechnology initiatives all over the world and a proven track record in cooperating with other members of the consortium.

FUNMOL • • •

Acronym: FUNMOL Project Title: Multi-scale Formation of Functional Nanocrystal-Molecule Assemblies and Architectures Participants:



Project Abstract: Recent developments in the design and synthesis of nanoscale building blocks as active elements in opto- or bio-electronic devices with tailored electronic functionality have the potential to open up new horizons in nanoscience and also revolutionise multi-billion dollar markets across multiple technology sectors including healthcare, printable electronics, and security. Ligand-stabilised inorganic nanocrystals (~2-30 nm core diameters) and functional organic molecules are attractive building blocks due to their size dependent optoelectronic properties, the availability of low-cost synthesis processes and the potential for formation of ordered structures via (bio) molecular recognition and self-assembly. Harnessing the complementary properties of both nanocrystals and functional molecules thus represents a unique opportunity for generation of new knowledge and development of new classes of high knowledge-content materials with specific functionality tailored for key applications, e.g., printable electronics, biosensing or energy conversion in the medium term, and radically new information and signal processing paradigms in the long term. Self-assembly and self-organisation processes offer the potential to achieve dimensional control of novel multifunctional materials at length scales not accessible to conventional “top-down” technologies based on lithography. It is critical for European industry to develop new knowledge and low-cost, scaleable processes for assembly and electrical interfacing of these multifunctional materials with conventional contact electrodes in order to produce into tailored devices and products, in particular on low-cost substrates. The FUNMOL consortium will deliver substantial innovation to European industry via development of cost-effective, scaleable processes for directed assembly of high-knowledge content nanocrystalmolecule materials into electrically-interfaced devices at silicon oxide, glass and plastic substrates.

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BRITISH BIOCELL INTERNATIONAL LIMITED (BBI), www.britishbiocell.co.uk , (UK) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) EVONIK DEGUSSA GmbH (DEG), , (DE) INSTYTUT FIZYKI POLSKIEJ AKADEMII NAUK (IFPAN), www.ifpan.edu.pl , (PL) USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. (IOCB), http://www.uochb.cas.cz , (CZ) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (TNI-UCC), www.ucc.ie , (IE) UNIVERSITAET BASEL (UNIBAS), www.unibas.ch , (CH) UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 (UPMC), www.upmc.fr , (FR)

GANANO • • •



Acronym: GANANO Project Title: New Generation of GaN-based sensor arrays for nano- and pico-fluidic systems for fast and reliable biomedical testing Participants: – – – – – – – – – –

ANALYTIK JENA AG (AJ), www.analytik-jena.de , (DE) EADS DEUTSCHLAND GMBH (EADS), www.eads.net , (DE) FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (FORTH), www.forth.gr , (EL) GE GLOBAL RESEARCH EUROPE GMBH (GEGR/E), www.research.ge.com , (DE) POLITECNICA DE MADRID (ISOM-UPM), www.upm.es , (ES) TOP-GAN SP ZOO (TOPGAN), www.topgan.fr.pl , (PL) TECHNISCHE UNIVERSITAET ILMENAU (TUI), www.tu-ilmenau.de , (DE) INSTYTUT WYSOKICH CISNIEN - POLSKIEJ AKADEMII NAUK (UNIPRESS), www.unipress.waw.pl , (PL) PANEPISTIMIO KRITIS (UNIVERSITY OF CRETE) (UOC), www.uoc.gr , (EL) TECHNISCHE UNIVERSITAET MUENCHEN (WSI-TUM), www.tu-muenchen.de , (DE)

Project Abstract: The goal of the project is to develop a novel Gallium Nitride (GaN) based integrated system for fast physical, chemical, and biological analysis of metabolits, Pharmaceuticals, proteins and pathogens in aqueous nano- and pico-droplets. The research is motivated by the need of hospitals and laboratories for tools enabling identification and screening of large numbers of samples contaning small volumes of disease-associated substances. High-rate, efficiency, and sensitivity of analytical sample-processing that are crucial for early detection of substances associated with diseases such as AIDS or Creutzfeldt-Jakob will directly contribute to improved quality of life and reduction of medical treatment costs. GaNano explores the frontiers of nanotechnologies through development and integration of electronic sensor arrays, optical components (visible and UV light emitters and detectors), and a nano-fluidic dosing device, to form a multifunctional system based on GaN micro- and nanostructures. Optimised for physical, chemical, and biological analysis of very small amounts of liquid, the system will support long-term innovations in bio-medical applications, industrial testing, and development of Pharmaceuticals. Specific objectives are to: - process GaN based electronic sensor arrays on transparent chips for chemical and physical analysis of nano- and pico-droplets, - develop InAIGaN/GaN optical sensor arrays combining UV light emitting and laser diodes with detector arrays for spatially and energy resolved fluorescence spectroscopy, - modify an inkjet-like dosing system for nano- and pico-droplets containing large biopolymer assemblies such as proteins or viruses, - develop and apply organic test substances and optical markers for nano- and picofluidic systems and functionalise sensor surfaces enabling selective biological characterisation, - integrate the dosing system with the electronic and optical sensor arrays into a multifunctional system.

GENSENSOR-NANOPARTS • • •

Acronym: GENSENSOR-NANOPARTS Project Title: Nano-biotechnical components of an advanced bioanalytical microarray system Participants: – – – – –



UNIVERSITAET BREMEN (CAG), www.uni-bremen.de , (DE) EXIQON A/S (EXIQON), www.exiqon.com , (DK) GENERI BIOTECH (GENERI BIOTECH), www.generi-biotech.com , (CZ) MILTENYI BIOTEC GMBH (MILTENYI), www.miltenyibiotec.com , (DE) PLANT RESEARCH INTERNATIONAL B.V. (PRI), www.plant.wur.nl , (NL)

Project Abstract: . Project summary A consortium of three companies and two academic research units from Czech Republic, Denmark, Germany and The Netherlands are working together to develop commonly a new approach for improving essential steps in the microarray based gene analytical method. Presently this method consists mainly of five parts, namely 1. extraction of the nucleic acids out of biological samples to be analysed, 2. preparation of the relevant target sequences by amplification, cDNA-synthesis and/or labelling, 3. hybridisation of the generated targets on microarrays, 4. measurement of the hybridisation signals and 5. analysis of the data. Since hybridisation, signal measurement and data analysis can be combined in an advanced microarray-based gene sensor system, innovative solutions are needed for getting out of the system quantitative results reflecting the real level of the different nucleic acids to be measured in the biological samples. For analysing those samples containing a large number of different sequences a reduction of the complexity of the nucleic acids mixture is needed. This task will be solved by the new nano-biotechnical component to be developed. It will recognise only a certain set of sequences during the extraction procedure and will allow to transfer these nucleic acids without further preparation steps to the microarray chips improving thereby the detection limit of the whole system. As part of an advanced online hybridisation microarray system ("gene sensor") the nano-structured surfaces of these components will also make possible to improve the robustness and reliability of microarray based DNA-analytical investigations, especially if low abundant species of nucleic acid molecules have to be detected and to be quantified in extracts containing an excess of other nucleic acids.

GOLEM • • •

Acronym: GOLEM Project Title: Bio-inspired Assembly Process for Micro- and Nano- Products Participants:



Project Abstract: While our knowledge on synthesizing nanostructures at the molecular level is progressing at a fast pace since the remarkable achievement of buckyballs and carbon nanotubes, our current understanding on how to interface and assemble parts from different materials is still limited. The GOLEM concept is to propose an approach based on bio-inspired events to assemble parts at the micro-/nano- scale. The objective is to mimic methods used by nature to interface organic and non-organic material (for example abalone shellfish provide a template for the crystallization of calcite into hard shell) and also, molecular recognition properties like antibodies/antigens, proteins receptors/ligands interaction or DNA hybridization to uniquely define mating pairs between nano-objects to assemble. The assembly process in itself is assisted or partially assisted by way of swarm micro-robots, fluidic systems (to direct a flow of parts) or through laser-trapping techniques. The GOLEM science and technology objectives are: * To understand and investigate the bio-inspired bindings suitable for non-organic materials. * To characterize the assembly process at the micro-/nano- scale (geometry, bonding forces, repeatability, etc.) using dedicated tools. * To develop tools and methods to selectively functionalized surfaces on which bio-molecules are attached to. * To implement a demonstration of assembled device using bio-inspired bonds. GOLEM will contribute at exploring the frontiers of knowledge by a systematic investigation of bio-inspired events as a "smart-glue" to bond non-organic material. GOLEM will also support long-term innovation by providing specifically developed micro-robotic instruments and methods to investigate nano- and micro- assembly that will be made to the European Research Community.

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COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) CESKE VYSOKE UCENI TECHNICKE V PRAZE (CTU), www.cvut.cz , (CZ) DELONG INSTRUMENTS AS* (DELONG), www.dicomps.com , (CZ) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) NPL MANAGEMENT LIMITED (NPL), www.npl.co.uk , (UK) OCTAX MICROSCIENCE GMBH (OCTAX), www.octax.de , (DE) KURT QUINTENZ (QUINTENZ), www.quintenz.de , (DE) TECHNISCHE UNIVERSITEIT EINDHOVEN (TUE), www.tue.nl , (NL) THE UNIVERSITY OF EDINBURGH (UEDIN), www.ed.ac.uk , (UK) UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 (UPMC), www.upmc.fr , (FR) UNIVERSITAET STUTTGART (USTUTT), www.uni-stuttgart.de , (DE)

GSOMEN • • •

Acronym: GSOMEN Project Title: Growth and Supra-Organization of Transition and Noble Metal Nanoclusters Participants:



Project Abstract: A combined experimental and theoretical effort is undertaken to clarify (1) the mechanisms of nucleation and growth of bare and coated transition and noble metal nanoclusters, (2) the supra-organization of these nanoparticles in 1D, 2D and 3D super-structures, (3) the structure-properties relationships, with a full exploitation of the peculiar properties of these systems as the ultimate goal. Bare metal nanoparticles are grown by direct in situ vapor deposition on oxide surfaces in UHV conditions. Coated metal nanoparticles are obtained by synthesis in homogeneous phase either using reverse micelles as nanoreactors or from the aggregation of solvated metal atoms, and subsequently deposited on the substrates. Oxide substrates are nanopatterned with the aim of achieving the full control of the supra-organisation of the nanoclusters in different kinds of superlattices.Information on the basic metal-support, metal-ligand and nanoparticle-nanoparticle interactions is derived from the interplay of calibrated experiments and first-principle calculations, and is used to build up appropriate interparticle potentials. These potentials are utilized in molecular dynamics and kinetic Monte Carlo simulations of the various growth processes under realistic conditions, from which a direct comparison with actual growth experiments is immediately possible. Once the structural properties are elucidated, general features of the structure-property relationships will be investigated.The aim is to achieve control over the size, size distribution, morphology and properties of nanoparticles and super-lattices.

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COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) ISTITUTO NAZIONALE PER LA FISICA DELLA MATERIA. (INFM), www.infm.it , (IT) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) TECHNISCHE UNIVERSITAET MUENCHEN (TUM), www.tu-muenchen.de , (DE) UNIVERSITAET GRAZ (UG), http://www.uni-graz.at , (AT) UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 (UPMC), www.upmc.fr , (FR) UNIVERSITAET ULM (UULM), , (DE)

HENIX • • •

Acronym: HENIX Project Title: Enhanced Nano-fluid Heat Exchange Participants:



Project Abstract: Henix will translate promising laboratory based nanotechnology results into pilot lines for the production of nanofluid coolants. This project, conceived and led by its European industrial partners, is designed to improve the competitiveness of European industry by developing new and more efficient cooling technologies and processes; specifically a new, state of the art, nanofluid coolant with a significantly enhanced technological capabilities that will transform the design and performance of thermal management systems. Nanofluid coolants represent a new exploitation of nanotechnology that has only become possible as a result of recent advances in nanoparticle production and dispersion technology. The beneficial adoption of nanofluid coolants usually requires re-design of the whole system including heat exchangers, pumps, pipe work and operating points. The gains come from a subtle re-balancing of the pump power, heat losses, plant cost and thermal efficiency. Flow regimes and the geometry of cooling channels play a key role. Understanding how to design systems to realise these benefits is a bottleneck to industrial adoption of nanofluids coolants. The mechanism of how heat transfer is facilitated by nanoparticles in carrier fluids is not clearly understood by the global research community. Analytical Models as yet do not fully explain and predict the thermal performance of nanofluid coolants. The advancement of this knowledge will enable engineers to readily design heat systems using nanofluid coolants. The most promising application opportunities for nanofluid coolants reside in large information data centres containing computer servers and racks, power electronics and power electronics for electric drives. The project will stimulate and accelerate the industrial take-up of nanofluid coolants used to innovate next generation heat exchangers to more effectively cool equipment and machinery, significantly reducing energy consumption and costs by up to 50%.

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Centre for Process Innovation Limited (CPI), www.uk-cpi.com , (UK) DISPERSIA LIMITED (DLTD), www.dispersia.co.uk , (UK) AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE,L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE (ENEA), http://www.enea.it , (IT) ISIS R&D Srl (ISIS), www.isis-rd.com , (IT) ITN NANOVATION AG (ItN), www.itn-nanovation.com , (DE) KUNGLIGA TEKNISKA HOEGSKOLAN (KTH), www.kth.se , (SE) SIEMENS AG (siemens), www.siemens.com , (DE) Thermacore Europe Ltd (Thermacore), www.thermacore-europe.com , (UK) TECHNISCHE UNIVERSITEIT EINDHOVEN (TUE), w3.tue.nl , (NL) THE UNIVERSITY OF BIRMINGHAM (UBM), www.bham.ac.uk , (UK) UNIVERSITEIT TWENTE (UTW), www.utwente.nl , (NL) WEIZMANN INSTITUTE OF SCIENCE (Weizmann), www.weizmann.ac.il , (IL)

HINAMOX • • •



Acronym: HINAMOX Project Title: Health Impact of Engineered Metal and Metal Oxide Nanoparticles: Response, Bioimaging and Distribution at Cellular and Body Level Participants: – – – – – – – – –

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES (CICBIOMAGUNE), www.cicbiomagune.es , (ES) CENTRO DE INVESTIGACION EN QUIMICA APLICADA (CIQA), www.ciqa.mx , (MX) TYOETERVEYSLAITOS. (FIOH), www.ttl.fi , (FI) EDUCACAO E ENSINO SUPERIOR DO ALTO AVE S.A. (ISAVE), www.isave.pt , (PT) DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO (NRCWE), www.nrcwe.dk , (DK) PLASMACHEM PRODUKTIONS- UND HANDELGMBH (PLASMACHEM), http://www.plasmachem.com , (DE) UNIVERSITAET LEIPZIG (ULEI), http://www.uni-leipzig.de , (DE) DE VIGO (UVIGO), www.uvigo.es , (ES) Zhejiang University (ZJU), www.zju.edu.cn , (CN)

Project Abstract: Metal oxide and metal NPs are particularly dangerous for two reasons: their special catalytic activity coming from the properties of their nanointerface may interfere with numerous intracellular biochemical processes and the decomposition of NPs and the ion leakage could heavily interfere with the intracellular free metal ion homeostasis, which is essential for cell metabolism. A very specific problem is the difficulty of localizing and quantifying them in cells. Obtaining dose effect relationships is not simple, because of the unknown amount of material present in affected cells. The following main points will be addressed in this proposal:1) Design and synthesis of metal oxide and metal NPs, which can be traced by SPECT, PET, and fluorescence techniques and the appropriate characterization of these NPs.2) Application of label-free techniques, such as IBM and EM to ensure that the radioactive and fluorescent constituents do not modify the cytological and organismic response by themselves.3) Characterization of the uptake, distribution kinetics and NP release at the level of the organism.4) Study of the interaction of NPs with plasma components forming complexes with NPs and the assessment of their possible impact on the uptake compared with that of bare or capped particles.5) Quantification and localization of metallic NPs in immune competent cells is a key task for the establishment of proper dose-response correlations. A technique applicable with living cells as ultimate control will be IBM, capable of detecting single metal NPs in cells at different depths.6) Development of sophisticated cell physiological approaches focusing on the determination of oxidative activity, cytokine production and adaptive processes concerning signalling pathways beyond standard vitality tests. The research project will indicate toxic levels of various NPs and sub-toxic effects will be investigated by analysing the signalling response of immune cells

HY3M • • •

Acronym: HY3M Project Title: Hydrogen-bond geared Mechanically interlocked Molecular Motors Participants:



Project Abstract: Hy3M will create new types of synthetic molecular motors - fuelled by energy in the form of light, heat, electrons, etc. - that transmit effects of mechanical motion at the molecular level through to the macroscopic world. The project will (i) explore and develop new methods and mechanisms for controlling the directionality of sub-molecular translational and rotary motion, principally through manipulating hydrogen bonding interactions, and (ii) find out how to link such movements to the outside world in order to do useful work. The focused program of targeted multidisciplinary research with groups from Chemistry, Physics, and Engineering involves complementary synthetic, spectroscopic, computational, structural and fabrication studies. Six workpackages are aimed at obtaining an assessment of both the static and dynamic influences of mechanical interlocking at the molecular level, the ability to assemble the structures into films or polymers which must be engineered into a useful material, and an understanding of how key proximity effects could be designed in to tailor specific properties. The knowledge generated from these workpackages is employed to produce materials that exhibit various types of macroscopic responses from mechanical motion at the molecular level (surfaceproperty change, shape-change, movement of object) as well as a synthetic molecular motor coupled to the outside world to do work. Appropriate compounds will be produced on a practical scale and fabricated to produce a material that will permit evaluation for efficacy and device applications. Increasingly tougher performance, economic, and environ- mental requirements for materials necessitate the development of new approaches. Manipulating material properties by controlling molecular architecture, such as that envisaged in this project, is a promising emerging technology in this regard. The prospects for economic development are thus strong.

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ITS TESTING SERVICES (UK) LIMITED (ASG), , (UK) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) RIJKSUNIVERSITEIT GRONINGEN (RUG), www.rug.nl , (NL) UNIVERSITE D'ANGERS (UNIAN), www.univ-angers.fr , (FR) ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA (UNIBO), www.unibo.it , (IT) THE UNIVERSITY OF EDINBURGH (UNIED), www.ed.ac.uk , (UK) UNIVERSITEIT VAN AMSTERDAM (UVA-HIMS), www.uva.nl , (NL)

ICPCNANONET • • •



Acronym: ICPCNANONET Project Title: A web-based repository of nanoscience and nanotechnology publications, database of researchers and online forum, to inform and facilitate networking between EU and ICPC RTD Participants: – – – – – – –

CHINESE SOCIETY OF MICRO-NANO TECHNOLOGY - CSMNT (CSMNT), www.csmnt.org.cn , (CN) SAINT PETERSBURG ELECTROTECHNICAL UNIVERSITY LETI (ETU), www.eltech.ru , (RU) INSTITUTE OF NANOTECHNOLOGY (IoN), www.nano.org.uk , (UK) JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (JNCASR), www.jncasr.ac.in , (IN) UNIVERSITEIT MAASTRICHT (MERIT, University of Maastricht), http://www.maastrichtuniversity.nl , (NL) MALSCH TECHNOVALUATION (MTV), www.malsch.demon.nl , (NL) SOCIEDADE PORTUGUESA DE INOVACAO - CONSULTADORIA EMPRESARIAL E FOMENTO DA INOVACAO S.A. (SPI), www.spi.pt , (PT)

Project Abstract: The ICPCNanoNet project aims to provide an electronic archive of nanoscience and nanotechnology research publications and support the networking of researchers in the EU and ICPC. The electronic archive will be based on open-source software (EPrints) that is widely used by scientific institutions across the globe, and allows the incorporation of full-text open access publications (submitted by authors themselves) and the incorporation of entries from other publicly available sources (including other open-access repositories, electronic tables of contents and abstracts). This will facilitate researcher access to new data and the identification of groups that are performing complementary research for potential collaboration. ICPCNanoNet will also establish a database of researchers and organizations in the EU and ICPC, which will include contact details, research interests and expertise. This database will be available to all registered users of the website, allowing researchers to search for individuals that have specific expertise and organizations that have desired instrumentation and capacity. Researchers will be able to contact each other through an internal mail forwarding system and online discussion fora. It will identify research strategies and organization activities within the eight ICPC regions: Africa; Caribbean; Pacific; Asia; Eastern Europe and Central Asia; Latin America; Mediterranean Partner Countries; and Western Balkan Countries. These will be reported on an annual basis and available to download from the website. It will actively network EU and ICPC researchers through annual workshops, to be held in the EU; China; India; and Russia, and through the webcasting of these workshops and separate online workshops, where wider participation can be achieved.

IMPART • • •

Acronym: IMPART Project Title: Improving the understanding of the impact of nanoparticles on human health and the environment Participants: – – – – – – – – – – – – – – – – – – – – – – – – –

INSTITUTE OF INFORMATION TECHNOLOGIES OF THE BULGARIAN ACADEMY OF SCIENCES (BAS), www.bas.bg , (BG) STICHTING BIOMADE TECHNOLOGY (BIOMADE), www.biomade.nl , (NL) CHALEX RESEARCH LTD (CHALEX), www.chalex.co.uk , (UK) CMP CIENTIFICA S.L. (CMPC), www.cmp-cientifica.com , (ES) TECHNOLOGY CODES LTD (CODES), www.techcodes.com , (IE) DUBLIN INSTITUTE OF TECHNOLOGY DIT (DIT), , (IE) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) FORSCHUNGSZENTRUM KARLSRUHE GMBH (FZK), www.fzk.de , (DE) INSTITUTE OF PHYSICAL CHEMISTRY I.G. MURGULESCU OF THE ROMANIAN ACADEMY (IPC), www.icf.ro , (RO) INSTITUT JOZEF STEFAN (JSI), www.ijs.si , (SI) KAUNO TECHNOLOGIJOS UNIVERSITETAS (KTU), www.ktu.lt , (LT) LATVIJAS TOKSIKOLOGU BIEDRIBA (LATTOX), , (LV) NFM - NANOFUNCTIONAL MATERIALS CONSORTIUM (NFM), www.nfm.org.il , (IL) INSTYTUT MEDYCYNY PRACY NOFERA (NIOM), www.imp.lodz.pl , (PL) NATIONAL INSTITUTE OF RESEARCH AND DEVELOPMENT FOR TECHNICAL PHYSICS (NIRDTP), www.phys-iasi.ro , (RO) TEMAS AG TECHNOLOGY AND MANAGEMENT SERVICES. (TEMAS), , (CH) TEKNILLINEN KORKEAKOULU (TKK), www.tkk.fi , (FI) TECHNISCHE UNIVERSITAET MUENCHEN (TUM), www.tu-muenchen.de , (DE) UNIVERSITATEA DIN CRAIOVA (UCV), , (RO) UNIVERSITY OF LEICESTER (ULEI), www.le.ac.uk , (UK) KATHOLIEKE UNIVERSITEIT LEUVEN (ULEU), www.kuleuven.be , (BE) THE UNIVERSITY OF MANCHESTER (UMAN), www.manchester.ac.uk , (UK) PANEPISTIMIO KRITIS (UNIVERSITY OF CRETE) (UNICRETE), www.uoc.gr , (EL) UNIVERSITY OF SURREY (UNIS), www.surrey.ac.uk , (UK) VDI TECHNOLOGIEZENTRUM GMBH (VDI), www.vditz.de , (DE)

IMPART cont. •

Project Abstract: Nanotechnology is finding increased application in todays society and is being hailed as the next industrial revolution. Companies around the world are beginning to mass-produce nanoparticles (particles less than 100 nm in size) for use in everything from sunscreens to soil reclamation. The production of anthropogenically-derived nanoparticles will inevitably result in the introduction of these materials to the environment. However, despite rapid advances in nanotechnology, knowledge of the potential risks of nanoparticles to human health and the environment is limited. There is a concern that size matters with respect to toxicity, irrespective of the chemical composition. There are fears that materials that are biologically inert in bulk tend to become harmful in ultrafine particle form. Analogies have been drawn, for example, on the similarity of the structure of carbon nanotubes to asbestos fibres, whose detrimental effects on human health are well documented. There is a need to encourage greater understanding of the short and long term implications of nanotechnology for health and the environment. The primary aim of this CA is to prevent knowledge of the health and environmental implications of nanoparticles from lagging behind the technological advances. In order to do this, IMPART will foster communication links between a number of regional, national and international initiatives in order to reduce duplication of effort, pool expertise and facilitate co-operation between networks. This will result in an improvement in the understanding of the potential impact of nanoparticles on human health and the environment.

INDOT • • •

Acronym: INDOT Project Title: MOCVD technology for production of indium nitride based nanophotonic devices Participants:



Project Abstract: The main objective of this project is to develop an MOCVD technology (Equipment, Precursors, Gas purification and Growth processes) for the industrial production of Indium Nitride (InN) quantum dot based devices. The know-how produced will also be applicable to the production of InN and In-rich InGaN alloy based devices. On a purely scientific basis, this project will address the epitaxy of a new, challenging and extremely promising semiconductor material, InN, and its nanostructures. This material has a huge potential for applications in infrared emission and detection, for telecommunication applications, high efficiency solar cells and electro-optic modulators. Another aspect of the proposed project is linked to environmental issues. Nitride semiconductor growth is a much more environmental friendly technology compared to the state of the art since it involves non-toxic precursors. The consortium consists of three industrial partners (AIXTRON, EPICHEM, SAES Getters) and one international level academic laboratory (GES). They will join their complementary expertise to develop the advanced MOCVD technology for InN based nanophotonic devices. The workplan has 9 technological and scientific workpackages and 1 related to management issues. The work will be realized through a strong interaction between all partners. GES will qualify the new precursors, MOCVD and purifier technology and will use those for the process design. Based on the process results the equipment and precursors will continuously be optimized. At the end of the project, an InN nanostructure based LED will be realized as demonstrator, to qualify the whole production technology developed in the frame of the project. The project addresses the key activity NMP-2004-IST-NMP-3 of the second joint IST NMP call FP6-2004-IST-NMP2.

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AIXTRON AG (AIXTRON), www.aixtron.com , (DE) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) SAFC HITECH LIMITED (EPICHEM), www.safchitech.com , (UK) SAES GETTERS SPA (SAES), www.saesgetters.com , (IT)

INGENIOUS • • •

Acronym: INGENIOUS Project Title: Innovative Nanostructured Optochemical Sensors Participants: – – – –



AARHUS UNIVERSITET (AU), www.au.dk , (DK) CENTRALNY INSTYTUT OCHRONY PRACY - PANSTWOWY INSTYTUT BADAWCZY (CIOP-PIB), www.ciop.pl , (PL) NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO (TNO), www.tno.nl , (NL) DE VIGO (UVIGO), www.uvigo.es , (ES)

Project Abstract: Polycyclic Aromatic Hydrocarbons (PAH’s) and VOCs like benzene, toluene and xylenes (BTX) are compounds of great social and environmental significance, are widely used in industry, in many different applications. However, they and can present serious medical, environmental, and explosion dangers. Because they are toxic even at parts per- billion concentrations, it is essential to know their concentration in the air, especially in industrial and populated areas. Measurement of these toxic compounds at trace levels in multi analyte mixtures is still a challenging task however, and involves the use of expensive laboratory bound equipment. This severely limits risk analysis and timely initiation of preventive measures in a working environment. The main objective of the INGENIOUS project is the development, evaluation and validation of novel ultra-sensitive and selective nanostructured optochemical sensors for the detection of PAHs (polycyclic aromatic hydrocarbons) and BTX (benzene, toluene, xylene) from complex mixtures. Within the sensor concept, nanoparticle-based materials with high selectivity and sensitivity will be created by combining principles of molecular imprinting and plasmonic enhancement of molecular fluorescence. Silica and polymer core-shell nanoparticles with molecularly imprinted shells will be used as building blocks of self-assembling colloidal aggregates acting as chemosensing elements. The sensing elements and microarrays of sensing elements will be obtained using modern printing technologies such as ink-jet and microcontact printing. The combined sensor elements will be implemented on a polymer foil format and validated as sensor transducers. The technology will be incorporated into an in-plane optical read-out platform and demonstrated for specific end user applications. The suggested approach will be used to create sensor devices capable of detecting relevant analytes in industrial processes, occupational health and plants safety like PAH

INLIVETOX • • •

Acronym: INLIVETOX Project Title: Intestinal, Liver and Endothelial Nanoparticle Toxicity Development and evaluation of a novel tool for highthroughput data generation. Participants: – – – – – – – –



ALMA CONSULTING GROUP SAS (ALMA), www.almacg.com , (FR) CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT (CSEM), www.csem.ch , (CH) HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH (HMGU), www.helmholtzmuenchen.de , (DE) KIRKSTALL LIMITED (KIRKSTALL), www.kirkstall.org , (UK) EDINBURGH NAPIER UNIVERSITY (NU), www.napier.ac.uk , (UK) UNIVERSITA DI PISA (UNIPI), www.unipi.it , (IT) UNIVERSITY OF ROCHESTER (URMC), www.urmc.rochester.edu , (US) UNIVERSITAET DES SAARLANDES (USAAR), www.uni-saarland.de , (DE)

Project Abstract: The InLiveTox project will form an interdisciplinary consortium at the European level, together with a key American research group to develop an improved in vitro model for the study of nanoparticle (NP) uptake, transport and cellular interaction, thus advancing our understanding of NP toxicity. Rather than repeat what has, or is being done in the field of aerosol NP and lung toxicology, InLiveTox will focus on the impact of NP exposure via ingestion, in the healthy and diseased gastrointestinal (GI) tract, vascular endothelium and liver. The key questions in this study are: (i) How do these tissues individually respond to NPs? (ii) How do the interactions between the different tissues modulate their responses? (iii) How does inflammation affect the toxicity of NPs and their ability cross the intestinal barrier? (iv) Which physico-chemical characteristics of NPs influence their uptake by intestinal epithelial cells and their subsequent interactions with endothelial and liver cells? The objective of InLiveTox will be to develop a novel modular microfluidics-based in vitro test system modelling the response of cells and tissues to the ingestion of NPs. Cell culture modules of target tissues such as the GI tract, the liver and the endothelium will be connected via a microfluidics system so that knock-on and cross talk effects between organs and tissues can be monitored. A major innovative aspect of the InLiveTox project pertains to the implementation of biological tissue models in a microfabricated compartmental cell culture system that allows multiple cell types to be addressed and investigated in combination. This system will be much easier, more convenient and ethically less questionable than animal testing, as well as more relevant than the in vitro single cell /co-culture models currently used. For this study, applications of the model will focus on NP toxicology, but the system could also be widely used in various applications of toxicology and pharmacology.

INNOSHADE • • •



Acronym: INNOSHADE Project Title: Innovative Switchable Shading Appliances based on Nanomaterials and Hybrid Electrochromic Device Configurations Participants: – – – – – – – – – – – – – – – – –

AKZO NOBEL CHEMICALS BV (AKZO NOBEL), www.akzonobel.com , (NL) ARCELIK A.S. (ARCELIK), http://www.arcelikas.com.tr/Cultures/en-US/ , (TR) FUNDACION CIDETEC (CIDETEC), www.cidetec.es , (ES) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) COATEMA COATING MACHINERY GMBH (COATEMA), , (DE) EADS DEUTSCHLAND GMBH (EADS), www.eads.net , (DE) ESSILOR INTERNATIONAL SA (ESSILOR), www.essilor.com , (FR) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (Fraunhofer), www.fraunhofer.de , (DE) GORENJE GOSPODINJSKI APARATI D.D. (GORENJE), , (SI) HYDRO-QUEBEC (IREQ), www.hydroquebec.com , (CA) LCS LIFE CYCLE SIMULATION GMBH (LCS), www.lcslcs.de , (DE) MICROELETRONICA MASER SL (MASER), www.grupo-maser.com , (ES) KEMIJSKI INSTITUT (NIC), http://www.ki.si , (SI) SOLEMS SA (SOLEMS), www.solems.com , (FR) CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI (UMIB-INSTM), www.instm.it , (IT) E DO MINHO (UMINHO), www.uminho.pt , (PT) VYZKUMNY USTAV ORGANICKYCH SYNTEZ A.S. (VUOS), www.vuosas.cz , (CZ)

Project Abstract: INNOSHADE is concerned with an innovative, nanocomposite-based switchable light transmittance technology developed previously for small sized objects (eyewear). It constitutes a breakthrough in smart shading technology by overcoming common limitations of state-of-the-art electrochromic devices. INNOSHADE enables the low cost production of electrochromic shading appliances with lower energy consumption and faster response. The overall objective of the proposed project is to scale up and study the underlying nanotechnology-based processes from laboratory to pilot line production, with the major goal to explore and extend the application potential by creating interest in several prospective user groups across sectors. In three interrelated sub-projects dedicated to I. Ophthalmic lenses, II. Domestic appliances, and III. Aircraft and vehicle applications, procedures shall be implemented to establish pilot production lines for the individual device components as well as for their assembly to run-capable devices up to a size of 45 x 80 cm2 (automotive sunroof dimensions). Cost reduction will be accomplished via high through-put manufacturing methods such as continuous roll-to-roll processing to achieve demonstrators meeting essential market and consumer requirements. The work will be performed by a highly complementary, well-balanced consortium of 17 partners from 8 member states, 1 candidate state, and 1 third country, representing the entire value chain. The proposed research closely addresses main S&T, socio-economic and policy objectives of the NMP work programme (integration of disciplines, transformation to knowledge-intensive industry, improvement of competitiveness, high added value products), shows clear environmental benefits and contributes to Sustainable Development. Strong industrial participation (4 SMEs, 1 large enterprise, 5 partly multinational global players) reflects the high economic development perspectives of the project.

LAMAND • • •

Acronym: LAMAND Project Title: Large Area Molecularly Assembled Nanopatterns for Devices Participants:



Project Abstract: Scaling has driven the microelectronics industry for over 40 years and revolutionised information and communication technologies, health care, education, engineering, etc. Maintaining progress has becomes more challenging and costs of fabrication facilities are rising exponentially. Possible technical/cost solutions centre on development of ‘bottom-up’ techniques to (nano)pattern (the patterns yield device elements) surfaces rather than ‘top-down’ photolithographic (PL) methods that are the major cost of manufacturing circuitry (a single PL system is ~€65 million for next generation devices). Self-assembly is one route to nanopatterns but regularity/alignment over large areas is not consistent with circuit manufacture. Recent work on the self-assembly of block-copolymer (BCP) systems suggests that realisation of patterns of small feature size (~10 nm), at high density (i.e. spaced at ~10 nm), in precisely defined positions (to an accuracy of < 10 nm) on a large area substrate (12”) is possible. This proposal will develop BCP methodology into a set of process techniques for subsequent industrial pre-development. The methodology centres around a combination of bottom-up and topdown techniques to provide the fidelity required to make the methods reproducible and reliable. This proposal would have significant value:- - Enable continued development of devices towards their ultimate performance. Allow development of advanced circuitry at lower costs. - Prevent monopolisation of the semiconductor industry by 1 or 2 companies that can afford capital costs by opening the market to new competition. - Afford the EU with opportunities to develop profitable companies in materials, process equipment and emerging device technologies. Without a suitable EU-level engagement in this area, competition in the US and Asia will gain a significant technological lead that will minimise the EU’s potential to deliver new and advanced nano-electronic devices.

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS/LTM), www.cnrs.fr , (FR) CATALAN INSTITUTE OF NANOTECHNOLOGY (ICN), www.nanocat.org , (ES) INTEL PERFORMANCE LEARNING SOLUTIONS LIMITED (Intel), www.itic.intel.com , (IE) KANICHI RESEARCH SERVICES LIMITED (KAN), www.kanichi-research.com , (UK) PROFACTOR GMBH (PRO), www.profactor.at , (AT) SELCUK UNIVERSITESI (SU), http://www.selcuk.edu.tr , (TR) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (UCC-TNI), www.ucc.ie , (IE) UNIVERSITY OF NEWCASTLE UPON TYNE (UNEW), www.newcastle.ac.uk , (UK) UNIVERSITY OF IOANNINA (UOI), WWW.RC.UOI.GR , (EL)

MAGNIFYCO • • •

Acronym: MAGNIFYCO Project Title: MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE Participants:



Project Abstract: The aim of this project is the assembly and the fabrication of a new generation of multifunctional nanostructures for performing combined hyperthermia and controlled drug release, specifically targeted to cancer cells. The “magnetic nanocontainers” we intend to develop can perform at the same time cell recognition, hyperthermia treatment, and, as a consequence of the heat and /or cell environment stimuli, the release of drug with high selectivity for ovarian carcinoma. These multifunctional tasks are made possible due to the inclusion of three main components: a) the magnetic nanoparticles, allowing detection by MRI, cancer treatment by hyperthermia and providing stimuli for drug release; b) the nanocontainers, which allow for drug encapsulation and protection from degradation, facilitate the release of the drug upon application of an external stimulus, such as heat, or an internal one, such as the acidic pH of the tumour cells; c) the antibody fragments attached to the surface of the magnetic nanocontainers to deliver them selectively to the ovarian cancer cells. The individual building blocks and their assemblies will be characterized with respect to physical, chemical, and biological features, followed by dissemination of the newly acquired knowledge. Cell culture experiments will allow to understand the performance of such nano-tools in vitro. Directed towards application in patients, in vivo animal studies will be carried out on the most successful magnetic nanocontainers. The objectives of this proposal cover a wide range of scientific fields, hence a truly interdisciplinary collaboration between chemists, physicists, and biologists is required. To this end, we propose a european network collaboration between academic partners, who will take care of the development of new solutions for nanofabrication, and industrial partners implied in the field of the proposed application who will evaluate/develop the materials and act as advisors for risks arising during the project.

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CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) DOMPE PHA.R.MA SPA (DOMPE), http://www.dompe.it , (IT) FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IIT), www.iit.it , (IT) FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI (INT), www.istitutotumori.mi.it , (IT) MAGFORCE NANOTECHNOLOGIES AG (MagForce), http://www.magforce.com , (DE) Asociacion - Centro de Investigacion Cooperativa en Nanociencias - CIC NANOGUNE (nanoGUNE), www.nanogune.eu , (ES) NANOVECTOR SRL (NANOV), www.nanovector.it , (IT) COMPLUTENSE DE MADRID (UCM), , (ES) UNIVERSITEIT TWENTE (UNI-TWE), www.utwente.nl , (NL) E DE SANTIAGO DE COMPOSTELA (USC), http://www.usc.es , (ES)

MAGPRO²LIFE • • •

Acronym: MAGPRO²LIFE Project Title: Advanced Magnetic nanoparticles deliver smart Processes and Products for Life Participants: – – – – – – – –

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BUHLER AG (BUH), www.buhlergroup.com , (CH) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) Eidgenössische Technische Hochschule Zürich (ETH), www.ethz.ch , (CH) fluIT Biosystems GmbH (FLUIT), www.fluit-biosystems.de , (DE) Karlsruher Institut fuer Technologie (KIT), www.kit.edu , (DE) KMPT AG (KMPT), www.kmpt.com , (DE) MERCK KGAA (MEK), www.merck.de , (DE) INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE-INCDTIM CLUJ-NAPOCA (NIIMT), , (RO) INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR PLASMEI SI RADIATIEI (NILPRP), www.inflpr.ro , (RO) ACADEMIA ROMANA - FILIALA TIMISOARA (RATB), http://acad-tim.tm.edu.ro/ , (RO) SOLAE DENMARK AS (SOL), www.solae.com , (DK) TECHNISCHE UNIVERSITAET BERGAKADEMIE FREIBERG (TUBAF), http://tu-freiberg.de , (DE) THE UNIVERSITY OF BIRMINGHAM (UBI), www.bham.ac.uk , (UK) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (UCD), www.ucd.ie , (IE) DE SALAMANCA (USAL), www.usal.es , (ES)

Project Abstract: Biotechnologically derived substances for large scale feed, food and pharma applications represent one of the most important sources of new products due to their precisely controlled structural and functional properties, potential for economic and responsible production and overall broad benefits to society through biocompatibility and sustainability. The costs of producing biomaterials are in many cases dominated by separation processes, which can constitute 80% of the total cost of production. Using smart magnetic adsorbent particles to selectively separate the target product out of a complex product mixture like the fermentation broth or bio-feed stock can drastically reduce costs. By using magnetic separation and extraction technologies to separate the magnetic carrier particles, novel processing ways emerge. The main objective of the MagPro²Life project is to scale-up innovative nanotechnology based processes defined in the previous NanoBioMag Project, funded by the EU under the FP6 programme (NMP3-CT-2005-013469), to pilot-line-scale and demonstrate those for bio, food and pharma applications. Link to market needs is represented by a preliminary product selection of natural soy based nutraceuticals or pharmaceuticals like Bowman-Birk Inhibitor (BBI), a proteases inhibitor for MS-treatment, and Lunasin which is in discussion to have anti-carcinogenic properties as well as recombinant proteins and nucleic acids (Fragment-Antibody-Binding and Phytase). The Consortium is driven by the potential the magnetic separation technology has for improving the value-chain in industrial production for emerging biotech, food and pharma markets.

MANUCONF08-09 • • •

Acronym: MANUCONF08-09 Project Title: Organization of Manufacture implementation conferences 2008-2009 Participants: – –

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CENTRE TECHNIQUE DES INDUSTRIES MECANIQUES (CETIM), http://www.cetim.fr , (FR) INESC PORTO - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES DO PORTO (INESC Porto), www.inescporto.pt , (PT) ASSOCIATION POUR LA PROMOTION ET LEDEVELOPPEMENT DES INDUSTRIES MECANIQUES (PROMECA), www.fim.net , (FR) SWEREA IVF AB (Swerea IVF), www.swereaivf.se , (SE) VERKET FÖR INNOVATIONSSYSTEM (VINNOVA), www.vinnova.se , (SE)

Project Abstract: Promoted by the MANUFUTURE platform and the DG research of the EC, an annual conference is hosted since 2003 by the country of the EU presidency. The event objective is to report on the progress of the Manufuture activities and debate the future of the European manufacturing industry and the conditions for its sustained development. These events are fundamental contributions to the governance of research and innovation in manufacturing with a real added value to the industry through a progressive selection of complementary themes. These conferences have become a vital event for strengthening the programmes and actions by contributing to effectively identify and fill in the gaps in the R&D programme support in a multi-annual strategy. This project objective is to organise two events, in 2008 and 2009, in the direct continuation of previous ones. The 2008 conference will be held under the French presidency with a focus on how European SMEs and regional developments can efficiently contribute to the industrial implementation of Manufuture roadmaps. The 2009 conference under the Swedish presidency will highlight how this implementation should lead to a sustainable European manufacturing industry taking into account environmental and social issues. The project proposes follow-up activities to link the two events organised with an active involvement of the competent National Authorities. In France the Ministry of Economy Industry and Employment –MEIE has labelled the 2008 event as an event of the French presidency and delegated FIM and CETIM to organise it. In Sweden, VINNOVA, the Governmental Agency for Innovation Systems, is directly involved in the organisation of the 2009 event. This reflects the strong commitment and support of national authorities in this project. The EC, the Manufuture community (high level and support groups, 22 national and regional platforms) and the national key players in manufacturing will be deeply involved in the conference.

MAO-ROBOTS • • •

Acronym: MAO-ROBOTS Project Title: Methylaluminoxane (MAO) activators in the molecular polyolefin factory Participants:



Project Abstract: MAO-ROBOTS address the aspects of call NMP2009-1.2-2 molecular factory. We aim to perform basic research on nano-to-micro-sized systems used for industrial polyolefin (PO) production in order to “develop sustainable processes for nano-structuring for specific applications which should present high potential industrial and/or market relevance.” Molecular PO factories consist of methylaluminoxane based structures and a transition metal complex often but not always anchored on a heterogeneous, nano-structured silica support. On the basis of an in-depth understanding of the molecular and supra-molecular assembly and construction principles of MAO we aim to: Create MAO building blocks with a narrow molecular weight distribution and optimum nanostructure in terms of their activation efficiency, probably in the range of molecular weights ≈1000g/mol, “to achieve components and/or systems with predictable and controllable properties such as the composition and physicochemical structure.” Identify the most productive nano-to-micro structural arrangement (molecular factory layout) of the components MAO, transition metal complex and silica support in order to create “structures with controlled properties over multiple scales, multi-component structures” Establish the basis for reproducible production of the above-identified and newly designed molecular PO factories. Develop methods for quality control of the polyolefin production process in the molecular PO factories on a laboratory scale. Validate the results for the newly developed molecular factories from the laboratory scale by a series of test runs in industrial polyolefin production facilities Stimulate the broader application of nano-structured MAO for an increased spectrum of molecular factories, thereby accessing a broader application range directed towards different specialty polyolefin-based products.

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CHEMTURA ORGANOMETALLICS GMBH (Chemtura), , (DE) Koninklijke DSM N.V. (DSM), www.dsm.com , (NL) FORSCHUNGSZENTRUM JUELICH GMBH (JUELICH), www.fz-juelich.de , (DE) SABIC PETROCHEMICALS BV (Sabic), www.SABIC.com , (NL) UNIVERSITY OF EAST ANGLIA (UEA), http://www.uea.ac.uk , (UK) Itä-Suomen yliopisto (UEF), www.uef.fi , (FI)

MDSPM • • •

Acronym: MDSPM Project Title: Equipment and Methodology for Multi-Dimensional Scanning Probe Microscopy Participants: – – – –



CREATEC FISCHER & CO. GMBH (CreaTec), , (DE) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (Empa), www.empa.ch , (CH) NANOSCAN AG (NanoScan), www.nanoscan.ch , (CH) THE PROVOST FELLOWS & SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (TCD), www.tcd.ie , (IE)

Project Abstract: The ability to perform scanning tunnelling spectroscopy simultaneously with a measurement of the vertical and lateral tip-sample interaction force and energy dissipation on selected atomic or molecular sites is the next revolution in scanning probe microscopy and will revolutionise entire areas of surface science. The aim is to develop, manufacture and commercialise a new UHV low temperature multi-dimensional scanning probe microscope (MDSPM). The two dimensional force and energy dissipation measurement is performed via microfabricated cantilevers with relatively high spring constants (200-2000N/m) which are simultaneously driven on their flexural and torsional oscillation modes with sub-Angstroem amplitudes. The deflection sensing is achieved by a focussing Fabry-Perot sensor with an up to 100 MHz bandwidth and an unprecedented sensitivity down to 1 fm/sqrt (Hz). The high bandwith allows the detection of higher oscillation modes and harmonics. While high resonance frequencies are favourable to measure local energy dissipation processes arising from stochastic force fluctuations the detection of higher harmonics may be used to directly reconstruct the force field from a sitespecific measurement performed at a selected surfaces site at one fixed tip-sample distance. The operation of the cantilever with ultrasmall amplitudes not only allows the direct measurement of the local force gradient but is ideal for scanning tunnelling spectroscopy with excellent signal-to-noise ratio necessitated by ultra-stable tipsample positioning. These advances in scanning probe microscopy instrumentation will not only allow to imaging of metallic, semiconducting and insulating surfaces with unprecedented resolution, but will revolutionize our understanding of entire areas of surface science such as: chemical reaction dynamics, local energy dissipation and excitations, nanoscale contacts and a rational approach catalyst design, to name a few.

MEDITRANS • • •

Acronym: MEDITRANS Project Title: TARGETED DELIVERY OF NANOMEDICINE Participants: – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – –

ACROSS BARRIER GMBH (ACROSS), www.acrossbarriers.de , (DE) STICHTING BIOMADE TECHNOLOGY (BIOMADE), www.biomade.nl , (NL) BRACCO IMAGING SPA (BRACCO), www.bracco.com , (IT) BAYER SCHERING PHARMA AG (BSP), www.bayerscheringpharma.de , (DE) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) CHARITE - UNIVERSITAETSMEDIZIN BERLIN (CHARITE), www.charite.de , (DE) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT (CSEM), www.csem.ch , (CH) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) KøBENHAVNS UNIVERSITET (CU), www.ku.dk , (DK) KøBENHAVNS UNIVERSITET (DFU), www.ku.dk , (DK) STICHTING VOOR FUNDAMENTEEL ONDERZOEK DER MATERIE - FOM (FOM), www.fom.nl , (NL) UNIVERSITEIT GENT (GHENT), http://www.ugent.be , (BE) GUERBET SA (GUERBET), www.guerbet.com , (FR) INTEGRATED DNA TECHNOLOGIES BVBA (IDT), www.rna-tec.com , (BE) INFUTURIA GROUP AG (INFUTURIA), www.infuturia.eu , (CH) MAGFORCE NANOTECHNOLOGIES AG (MAGFORCE), http://www.magforce.com , (DE) PHILIPPS UNIVERSITAET MARBURG (MARBURG), www.uni-marburg.de , (DE) MOLECULAR PROFILES LTD (MOLPROF), www.molprofiles.co.uk , (UK) N.V. ORGANON (ORGANON), www.organon.com , (NL) PCI BIOTECH AS (PCI), www.pcibiotech.com , (NO) PHILIPS ELECTRONICS NEDERLAND B.V. (PHILIPS), www.philips.com , (NL) PHILIPS TECHNOLOGIE GMBH (PHILIPSD), www.philips.com , (DE) ISTITUTO DI RICERCHE BIOMEDICHE ANTOINE MARXER RBM SPA (RBM), www.serono.com , (IT) RIJKSUNIVERSITEIT GRONINGEN (RUG), www.rug.nl , (NL) TECHNISCHE UNIVERSITEIT EINDHOVEN (TUE), www.tue.nl , (NL) UNIVERSITAET DES SAARLANDES (UDS), www.uni-saarland.de , (DE) UNIWERSYTET LODZKI (UL), www.uni.lodz.pl , (PL) UNIVERSITAIR MEDISCH CENTRUM UTRECHT (UMC UTRECHT), www.umcutrecht.nl , (NL) NACIONAL DE EDUCACION A DISTANCIA (UNED), www.uned.es , (ES) UNIVERSITA DEGLI STUDI DI TORINO (UNITO), www.unito.it , (IT) UNIVERSITEIT UTRECHT (UU), www.uu.nl , (NL) WEIZMANN INSTITUTE OF SCIENCE (WEIZMANN), www.weizmann.ac.il , (IL)

MEDITRANS cont. •

Project Abstract: MEDITRANS will develop systems for targeted delivery of nanomedicines, which will be broadly applicable to disease. The focus is on chronic inflammatory disorders and cancer. Such industrially developed targeted products will improve therapy and in vivo visualisation of drug delivery/release processes. Nanocarriers (nanoparticles, nanotubes, fullerenes), endowed with high targeting capabilities, will be designed in parallel with MRI probes that report on localisation of the targeted nanoparticulates, specific bio-markers, and the drug release process (MRI-guided drug delivery). For reproducible behaviour in vivo, these nanomedicines containing drug payloads (e.g. pDNA, siRNA, small molecular weight agents) will have their physicochemical/stability properties characterised. 'Smart' delivery systems, tested in vitro, able to recognise the target, and to cross-relevant biological barriers, will be investigated for their responsiveness to the microenvironment of the target site (e.g. local pH). Control of drug release, triggered by external physical means (e.g. temperature, light, magnetism, ultrasound) or by local stimuli within the pathological site (e.g. pH, enzymatic activity) will be investigated in vitro. Ways to direct the intracellular trafficking of nanocarriers, to achieve improved interaction with the intracellular target location, will be investigated. In vivo applicability will be evaluated in clinically relevant models of disease. Toxicology aspects, industrial scale-up feasibility, long term stability, and feasibility to prepare clinical grade material will be covered. Dissemination, training and exploitation will be done. MEDITRANS, duration 4 years, is a timely, interdisciplinary IP at the forefront of targeted nanomedicine, with a budget of 16.1M Euro, a grant of 11M Euro (68%), and 1581.75 person-months effort. The 30 partners (12 European countries) are from industry (8), SMEs (5), universities (11), and research institutes (6).

MEMBAQ • • •

Acronym: MEMBAQ Project Title: Incorporation of Aquaporins in Membranes for Industrial Applications Participants:



Project Abstract: In all living cells, channels transporting water - aquaporins - exist. They are proteins, which only transport pure H2O molecules. They have a unique selectivity and are extremely efficient being nature's own membrane systems. The purpose is to investigate whether these unique features can be industrially exploited: Recombinant aquaporin molecules will be embedded into water filtration membranes. Nano-biotechnological research of water transport in various organisms show that aquaporins have 100% selectivity: Only water molecules pass. They also maintain high water permeation rates. Membrane technology is another rapidly developing technology within filtration and separation. Substantial research is done to enhance efficiency of membranes. The MEMBAQ project combines these two research spearheads. This combination has never been done before. A new filtration membrane with aquaporins is in theory up to 50 times more efficient (energy input reduction). It is truly radical innovation of the water industries, for instance for water purification (billions of EUR is spent every year), salinity gradient energy production (exploitable potential is 2000 TWh annually), waste water reclamation (water re-use). The MEMBAQ project will 1) produce recombinant aquaporin, 2) design nanotechnological membrane by means of computer simulation, 3) incorporate aquaporins into stable membranes, 4) engineer membranes based on characterising towards pressure, ph etc., 5) and finally test such membranes in three applications: Water purification, osmotic energy, and waste water reclamation for re-use. US and Japan invest significantly more per capita than EU in nanotechnology. This gap is expected to widen in the next few years. In MEMBAQ, we use real market needs in the water sector as a driver for accelerated research and innovation in nanotechnology. Enormous potentials in filtering other fluids and gasses with natural proteins embedded in membranes exist.

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AQUAPORIN APS (AQ), www.aquaporin.dk , (DK) BEN-GURION UNIVERSITY OF THE NEGEV (BGU), www.bgu.ac.il , (IL) DHI (DHI), www.dhigroup.com , (DK) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) LUNDS UNIVERSITET (LU), www.lu.se , (SE) SYDDANSK UNIVERSITET (SDU), www.sdu.dk , (DK) DE MALAGA (UMA), , (ES) ANJOU RECHERCHE (VE), www.veoliaenvironnement.fr , (FR) VILNIAUS UNIVERSITETAS (VU), http://www.vu.lt , (LT)

MOFCAT • • •

Acronym: MOFCAT Project Title: Functional Metal Organic Frameworks as Heterogeneous Catalysts Participants: – – – – – – –



ENI SPA (ENI), www.eni.it , (IT) ECOLE SUPERIEURE DE CHIMIE, PHYSIQUE, ELECTRONIQUE DE LYON (ESCPE), www.cpe.fr , (FR) HALDOR TOPSOE AS (HTAS), www.haldortopsoe.com , (DK) STIFTELSEN SINTEF (SINTEF), www.sintef.no , (NO) HUMBOLDT-UNIVERSITAT ZU BERLIN (UBER), , (DE) UNIVERSITETET I OSLO (UIO), www.uio.no , (NO) UNIVERSITA DEGLI STUDI DI TORINO (UNITO-NIS), www.unito.it , (IT)

Project Abstract: Metal Organic Frameworks (MOFs) are novel organic-inorganic crystalline materials, promising to become a powerful and flexible family for different industrial uses within catalysis, adsorption and sensor technology, overcoming many of the limitations of Zeolites. MOFs may display extreme porosity, and their functionalities can be tailored by using functional precursors in their preparation or by post-functionalization using standard techniques of organic- and organometallic chemistry. These features will be studied in the present project for the development of new heterogeneous catalysts and gas adsorbents. The project aims at 1) developing reproducible and scalable synthesis procedures for known and new MOFs, also exploiting combinatorial techniques; 2) understand at the molecular level the interactions governing their stability, selfassembling and adsorption properties, by means of combined experimental and theoretical modeling efforts; 3) develop functionalization routes to create MOF-based single-site catalysts for two emerging industrial processes; 4) exploit the functionalized MOFs as catalysts in two emerging industrial processes; 5) exploit Pt-functionalized MOFs as catalysts for C-H activation at moderate conditions; 6) exploit MOF catalysts in selective oxidation and SCR reactions; and 7) exploit selected MOFs as adsorbent or storage media for non-condensable gases (hydrogen and methane). The work packages of the project comprise the synthesis, characterization, modeling, and testing of the materials, as well as a technology implementation plan for their production and use.

MONACAT • • •

Acronym: MONACAT Project Title: Monolithic reactors structured at the nano and micro levels for catalytic water purification Participants: – – – – – – – – –



AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) FACULDADE DE ENGENHARIA DA UNIVERSADE DO PORTO (FEUP), www.fe.up.pt , (PT) MEL Chemicals, a division of magnesium elektron limited (MEL), www.luxfer.com , (UK) Norta (Norta), www.ollo.lt , (LT) NTNU - NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET (NTNU), www.ntnu.no , (NO) UNIVERSITY OF BATH (UB), , (UK) POLITECNICA DE VALENCIA (UPVLC), , (ES) ANJOU RECHERCHE (VE), www.veoliaenvironnement.fr , (FR)

Project Abstract: This project aims at the preparation and testing of catalyst supported on structured reactors (ceramic and metallic honeycomb monoliths, metallic filters, carbon cloth) coated with nanocarbon materials (NCM), namely carbon nanofibers (CNF) and carbon nanotubes (CNT). This structured catalytic reactor will be used for catalytic water purification. Every partner responsible for testing the monoliths will focus on a different pollutant (Nitrates, organic matter…) and catalytic process (hydrogenation, oxidation) depending on the particular expertise of every partner. The properties of monolithic reactor coated with NCM, e.g. thin catalyst layer and mesoporosity, enable the control of the diffusion path and enhance the diffusion of reactant to catalytic sites. The objective is to achieve, via the use of monoliths coated with NCM, an intensification of the catalytic process in terms of improved selectivity, robustness, stability and performance while reducing energy requirements and byproduct generation with respect to the catalytic process using conventional reactors, as e.g. trickled bed or slurry

MONAD • • •

Acronym: MONAD Project Title: Molecular Motors-based Nanodevices Participants:



Project Abstract: The MONAD project will focus on the design, fabrication and implementation of dynamic nanodevices based on the purposeful interaction of nano-structured surfaces and nano-objects with protein linear molecular motors ubiquitous biological nano-machines responsible for biological functions as diverse as cell movement and division, transport of vesicles and muscle contraction. The project will develop novel hybrid nano-bio-devices which will allow (i) quasiimmediate diagnostics, compared with the present hours-long response time; (ii) entirely new, efficient high throughput drug discovery for critical diseases, e.g., cancer; and (iii) new methodologies to study the information storage and processing processes in individual cells, with wider impact on medicine and health care industry. This high level of interdisciplinary innovation will lead to further future new industrial applications, such as immediate, personalised diagnostics. The research consortium will undertake the whole innovation path on molecular-motors based devices, starting from fundamental science to the implementation of the research in demonstration devices for health care and industry. We can pursue this comprehensive science, technology and engineering knowledge transfer because of the existing synergism within the consortium between academia, research institutes and industry. In the context of NMP-2008-1.1-1 the MONAD project will advance the development of protein molecular motors-based devices, well beyond the state of the art, leveraging on, consolidating, and making sustainable the already commanding position of European research in this very specific, paradigmatic-shift emerging area. On a more general level, MONAD will advance and consolidate the high added value of European biomedical industry in the global world market, as well as providing a new high-added value economic rationale to the excellent European semiconductor device knowledge and capability.

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HOEGSKOLAN I KALMAR (HiK), www.hik.se , (SE) LUNDS UNIVERSITET (LU), www.lu.se , (SE) MEDIZINISCHE HOCHSCHULE HANNOVER (MHH), www.mh-hannover.de , (DE) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) PHILIPS ELECTRONICS NEDERLAND B.V. (Philips), www.philips.com , (NL) TRITAGEMA CONSULT SRL (Trit), , (RO) UNIVERSITA DEGLI STUDI DI PADOVA (UniPD), www.unipd.it , (IT) THE UNIVERSITY OF LIVERPOOL (UoL), www.liverpool.ac.uk , (UK) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD (UOXF.BL), www.ox.ac.uk , (UK)

MULTIPLAT • • •

Acronym: MULTIPLAT Project Title: Biomimetic Ultrathin Structures as a Multipurpose Platform for Nanotechnology-Based Products Participants:



Project Abstract: The goal of the MultiPlat project is to develop biomimetic proton conductive membranes with nanometer thickness (nanomembranes) through convergence of a number of fields. The primary application of this multipurpose nanotechnological platform is the next generation of fuel cells where it will replace the prevailing evolutionary modifications of the state of the art solutions. Secondary applications cover diverse fields, including photonics, sensorics, biointerfaces, medicine and others. The natural proton conductive nanomembranes are the most ubiquitous building element in biology. The core concept of the project is to postulate, introduce and fabricate a novel composite nanomembrane and to functionalize them through the integration of proton conducting nanochannels in a manner analogous to that in biological cells. At the same time the nanomembranes will be strengthened through the introduction of inorganic part. This functionalisation itself is a complex and largely unsolved issue. In this way the nanomembranes will merge artificial and biological properties. We intend to use convergence of diverse fields including physics, chemistry, biomimetics, and nanotechnology. The focus will be primarily on the use of various nanotechnology methods for nanomembrane fabrication, their functionalisation through lamination, surface patterning, inclusion of fillers and structural modification through the engineering of built-in nanochannels. The research should result in functional models and a breadboard model. The industrial partners will ensure the application of the results. The objectives of the project fully satisfy the call NMP-2008-1.1-1 Converging sciences and technologies (nano, bio, info, cogni). The expected impacts include breakthroughs in knowledge in the converging fields, important practical applications and industrial innovations, with major significance for clean energy production, environmental protection and welfare improvement.

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ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) NANOCYL S.A. (NANOCYL), www.nanocyl.com , (BE) PAXITECH (PAXITECH), www.paxitech.com , (FR) TECHNISCHE UNIVERSITAET WIEN (TUW), www.tuwien.ac.at , (AT) UNIVERSITAET LEIPZIG (UNL), http://www.uni-leipzig.de , (DE)

MULTIPLAT • • •

Acronym: MULTIPLAT Project Title: Biomimetic Ultrathin Structures as a Multipurpose Platform for Nanotechnology-Based Products Participants: –



COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR)

Project Abstract: The goal of the MultiPlat project is to develop biomimetic proton conductive membranes with nanometer thickness (nanomembranes) through convergence of a number of fields. The primary application of this multipurpose nanotechnological platform is the next generation of fuel cells where it will replace the prevailing evolutionary modifications of the state of the art solutions. Secondary applications cover diverse fields, including photonics, sensorics, biointerfaces, medicine and others. The natural proton conductive nanomembranes are the most ubiquitous building element in biology. The core concept of the project is to postulate, introduce and fabricate a novel composite nanomembrane and to functionalize them through the integration of proton conducting nanochannels in a manner analogous to that in biological cells. At the same time the nanomembranes will be strengthened through the introduction of inorganic part. This functionalisation itself is a complex and largely unsolved issue. In this way the nanomembranes will merge artificial and biological properties. We intend to use convergence of diverse fields including physics, chemistry, biomimetics, and nanotechnology. The focus will be primarily on the use of various nanotechnology methods for nanomembrane fabrication, their functionalisation through lamination, surface patterning, inclusion of fillers and structural modification through the engineering of built-in nanochannels. The research should result in functional models and a breadboard model. The industrial partners will ensure the application of the results. The objectives of the project fully satisfy the call NMP-2008-1.1-1 Converging sciences and technologies (nano, bio, info, cogni). The expected impacts include breakthroughs in knowledge in the converging fields, important practical applications and industrial innovations, with major significance for clean energy production, environmental protection and welfare improvement.

N2T2 DEVICES • • •

• •

Acronym: N2T2 DEVICES Project Title: NOVEL NANO-TEMPLATE TECHNOLOGY AND ITS APPLICATIONS TO THE FABRICATION OF NOVEL PHOTONIC DEVICES Participants: – – – – – – – –

MACDERMID AUTOTYPE LIMITED (AIL), , (UK) AIXTRON AG (AIXTRON), www.aixtron.com , (DE) UNIVERSITA DEGLI STUDI ROMA TRE (DEA), , (IT) HOLOTOOLS GMBH (HOLOTOOLS), www.holotools.de , (DE) MEDZINARODNE LASEROVE CENTRUM (ILC), www.ilc.sk , (SK) UNIVERSITAET LINZ (JKU-CD LABOR), , (AT) KONARKA AUSTRIA FORSCHUNGS UND ENTWICKLUNGS GMBH (KONARKA), , (AT) UNIVERSITY OF BATH (UOB), , (UK)

Project Abstract: Nano-templates fabricated from chemically stable, resistant materials provide a flexible basis for a range of fabrication technologies including forming, moulding, imprinting and hot embossing. The purpose of this proposal is to establish large-area novel nano-forming technologies based on patterning porous anodised alumina (Al2O3) and their application to the fabrication of organic solar cell devices, quantum dot based photonic LEDs/Lasers and photonic crystal structure elements. The specific aims are 1.To research and develop technologies compatible with semiconductor microfabrication technologies for nanopatterning using porous anodised alumina or titania thin films, to form arrays of ultra-small structures; 2.To apply porous anodised alumina nano-masking and nano-imprinting to selective area epitaxial growth, to produce GaN quantum dots of unparalleled size uniformity for enhanced light emitting devices and lasers; 3.To apply anodised nano-templates to the fabrication of novel high-aspect ratio photonic devices by nano-imprint lithography; 4.To apply self-ordered porous alumina nano-templates to the mass market fabrication of two-dimensional and three-dimensional photonic crystal structure devices in semiconductors, dielectrics and polymers. Meeting each aim will involve a detailed, multi-disciplinary programme of microfabrication and materials and device characterisation.

NABIS • • •

Acronym: NABIS Project Title: NANOBIOTECHNOLOGY WITH SELF-ORGANISING STRUCTURES Participants: – – – – – –



ADVALYTIX AG (AVX), www.advalytix.de , (DE) DIAGNOSWISS SA (DS), www.diagnoswiss.com , (CH) ECOLE NORMALE SUPERIEURE (ENS), , (FR) INSTITUT CURIE (ICR-GC), www.curie.fr , (FR) KUNGLIGA TEKNISKA HOEGSKOLAN (KTH), www.kth.se , (SE) NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN (NMI), http://www.nmi.de/englisch/welcome.html , (DE)

Project Abstract: The goal of this research project is to study and develop novel synergistic technologies for the next generation of high performance biochips, for future applications e.g. in accellerated drug discovery, diagnostics and personalized medicine. One of the key technologies relies on a predictable self-organization of fluids, using both static and dynamic formats will be utilized. The formats will be combined to overcome current bottlenecks in the automation of high throughput assays, and will also be used for the development of a new concept for automated chip replication. Other complementary technologies deal with surface-expanded high density bioprobe arrays, including the use of novel polymers. Also, novel magnetic bio nanowires, controlled by an external magnetic field onto a platform of magnetic nanodots, will be explored.It is anticipated that the use of these technologies will provide unique possibilities to increase ligand density, as well as enhanced kinetics, resulting in enhanced sensitivity and faster assay performance. A third technology based on externally applied surface acoustic waves will be incorporated into the platform, yielding extremely efficient agitation of nanodroplets. Finally, a nanoelectrochemical detection system will be developed. The technologies will be combined to yield an optimized nanoarray chip, including the novel fluid agitation and bio-nanowires principles. The optimized structure will be tested using standard bioassays, and the results obtained will be compared with performance data, obtained from similar experiments with state of the art biochips.

NACBO • • •

Acronym: NACBO Project Title: Novel and improved nanomaterials, chemistries and apparatus for nanobiotechnology Participants:



Project Abstract: This IP proposes the research, development and commercialisation of discrete but overlapping areas of material science, materials chemistry and supporting/applying hardware systems. It will deliver novel and improved solutions to emerging and current needs in biology, health, chemistry, process engineering and the environment. Most particularly its outputs intend to address molecular diagnostics. The project will also address training of individuals, at all levels, in areas of relevance to its work and promotion of public awareness and female participation in science, engineering and technology with respect to nanotechnology and biotechnology. Finally it intends to deliver an effective web based resource for reference purposes with respect to bio/environmental compatibility of materials and chemistries involved in nanotechnology. Technologically this project concentrates on 3 main themes where existing approaches, materials or methods are either limiting or non-existent and where market opportunities exist. These are (i) tailored, characterised nanoand micro- materials (including paramagnetic materials) based upon, silica, magnetite and carbon in the forms of paramagnetic nanoparticles, mesoporous molecular sieves, carbon nanotubes, nanorods, nanoporous surfaces and bidisperse silica, (ii) chemistries involving; surface activation leading to improved and controllable surface functionalisation of materials via electro- oxidation and chemical polymerisation of chiral dicarbazoles and dipyrroles and diene/dienophile interactions and chemistries relating to perfluorpolymers for improvements in bioseparative processes; contrasting agents including quantum dots and electron spin traps and novel assembly chemistries for synthetic nucleic acids and related monomer synthons and (iii) new hardware platforms and associated reagents for application of the above in molecular diagnostics processes particularly forensics, public health #

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BAR ILAN UNIVERSITY (BI), www.biu.ac.il , (IL) DIREZIONE CENTRALE DELLE POLIZIA CRIMINALE - CRIMINAPOL (C), www.poliziadistato.it , (IT) EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (ECU), , (CN) GENETIX LIMITED* (G), www.genetix.com , (UK) THE HEBREW UNIVERSITY OF JERUSALEM. (HU), www.huji.ac.il , (IL) SHEMYAKIN AND OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY - RUSSIAN ACADEMY OF SCIENCE (IBCH), www.ibch.ru , (RU) ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL'UMBRIA E DELLE MARCHE (IZ), www.pg.izs.it , (IT) UNIVERSITY OF KENT (K), , (UK) SIGMA-ALDRICH BIOCHEMIE GMBH (P), www.proligo.com , (DE) PHILIPS TECHNOLOGIE GMBH (RP), www.philips.com , (DE) SAVYON DIAGNOSTICS LTD (S), www.savyondiagnostics.com , (IL) HEALTH PROTECTION AGENCY HPA (SRMD (CPHL)), www.hpa.org.uk , (UK) UNIVERSITA' DEGLI STUDI DI URBINO CARLO BO (UU), www.uniurb.it , (IT)

NAD • • •

Acronym: NAD Project Title: NANOPARTICLES FOR THERAPY AND DIAGNOSIS OF ALZHEIMER DISEASE Participants:



Project Abstract: The search for effective therapies and early detection strategies for Alzheimer’s Disease (AD), the major cause of dementia in Europe, is imperative. It is known that β-amyloid (Aβ) peptide plays a central role in neurodegeneration. In AD brain, Aβ is released in a soluble form that progressively becomes insoluble forming aggregates; extracellular plaques mainly composed of Aβ are a hallmark of post-mortem brains. These premises strongly suggest brain Aβ as a possible target for therapy and diagnosis of AD. In addition, it is known that brain and blood Aβ pools are in equilibrium via the blood-brain-barrier (BBB). Accordingly, it has been reported that removal of blood Aβ may withdraw the excess of brain Aβ by a “sink” effect. Thus, blood Aβ is another potential target. The aim of this project is to utilize nanoparticles (NPs) specifically engineered for targeting brain Aβ, for the combined diagnosis and therapy (theranostics) of AD. NPs (liposomes, solid lipid NPs, polymeric-NPs) will be multiplefunctionalized with: i) a large arsenal of molecules (specific lipids, antiamyloidogenic drugs, polyphenols, heteroaromatic compounds, unnatural peptides and peptidomimetics, antibodies) interacting with Aβ in all aggregation forms, ii) PET or MRI contrast agents detecting such interaction, iii) molecules stimulating BBB crossing via the transcytotic route. Several artificial and cellular models will be used to fine-tune such features and to improve NPs biocompatibility, non-immunogenicity, non-toxicity and physical stability. Eventually, absorption, distribution, metabolism and excretion will be studied using animal models of AD. Different routes (i.v., oral, nasal) and protocols (two-step, NPs cocktails, aerosols) of administration will be utilized to boost NPs brain delivery. The prediction is that NPs will detect, disaggregate and remove Aβ brain deposits. In any case, NPs will interact with blood Aβ, withdrawing the excess of brain peptide by a “sink” effect.

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Academisch Medisch Centrum bij de Universiteit van Amsterdam (AMC), www.amc.nl , (NL) BIAL INDUSTRIAL FARMACEUTICA S.A. (BIAL), , (ES) BIOTALENTUM TUDASFEJLESZTO KFT (BIO), www.biotalentum.hu , (HU) CENTRO DE INVESTIGACION BIOMEDICA EN RED ENFERMEDADES NEURODEGENERATIVAS (CIBERNED), www.ciberned.es , (ES) GUERBET SA (GUER), www.guerbet.com , (FR) CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED (IC SAS), www.chem.sk , (SK) ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI (IRF), www.marionegri.it , (IT) KAROLINSKA INSTITUTET (KI), www.ki.se , (SE) NANOVECTOR SRL (NAV), www.nanovector.it , (IT) STAB VIDA, INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA. (STAB), , (PT) TURUN YLIOPISTO (U. Turku), , (FI) UNIVERSITEIT ANTWERPEN (UA), www.ua.ac.be , (BE) Københavns Universitet (UCPH), www.ku.dk , (DK) LANCASTER UNIVERSITY (ULANC), , (UK) UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (UNIMIB), www.unimib.it , (IT) UNIVERSITY OF PATRAS (UPAT), www.upatras.gr , (EL) UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 (UPMC), www.upmc.fr , (FR) UNIVERSITE PARIS-SUD XI (UPS), www.u-psud.fr , (FR) DEL PAIS VASCO (UPV), www.ehu.es , (ES)

NADINE • • •

Acronym: NADINE Project Title: Nanosystems for the early Diagnosis of Neurodegenerative diseases Participants: –

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ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS - ARMINES (ARM), www.armines.net , (FR) INSTITUT CURIE (CI), www.curie.fr , (FR) DIAGNOSWISS SA (DS), www.diagnoswiss.com , (CH) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) FLUIGENT SA (FG), www.fluigent.com , (FR) CONSIGLIO NAZIONALE DELLE RICERCHE (ICMR), www.cnr.it , (IT) CATALAN INSTITUTE OF NANOTECHNOLOGY (ICN), www.nanocat.org , (ES) KUNGLIGA TEKNISKA HOEGSKOLAN (KTH), www.kth.se , (SE) USTAV MAKROMOLEKULARNI CHEMIE AV CR, v.v.i. (MACRO), http://www.imc.cas.cz , (CZ) To be confirmed (MB), , (CZ) To be confirmed (PHARM), , (DK) To be confirmed (RAM), , (DK) To be confirmed (UKES), , (DE) Itä-Suomen yliopisto (UKU), www.uef.fi , (FI) UNIVERZITA PARDUBICE (UPCE), www.uni-pardubice.eu , (CZ) UNIVERSITE PARIS-SUD XI (UPS), www.u-psud.fr , (FR) UNIVERSITAET ULM (UULM), , (DE)

Project Abstract: Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal “metabiomarker” signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in biotechnology, nanoparticle synthesis, and nano-instrumentation to the development of fully integrated lab-on chip instruments able to perform elaborate multimodal biomarker analysis on a routine basis and at the ultrasensitive level required to allow minimally invasive tests. In particular, we aim at overcoming a major bottleneck on the path to this objective, which was identified in a previous project in the “HEALTH” priority: no satisfactory solution currently exists to bridge the several orders of magnitude between the nanoscale volumes at which ultrasensitive new generation sensors operate, and the often millilitre volumes of samples in which the molecules of interest must be found. For this, we shall combine innovations in pre-concentration, micro and nanofluidics, self-assembly, micro-nanofabrication, and nanodetection. The project will develop a generic, multipurpose, platform of compatible enabling technologies, and integrate them into devices. In order to maximize impact and societal benefit, the project will be validated on an application of major interest for health, namely the early detection of biomarkers for neurodegenerative diseases (including Alzheimer), with special emphasis on subtyping of these diseases for improved treatment strategies. The consortium includes a multidisciplinary group of technology developers, three leading biomedical groups in clinical neuroscience for definition of specifications and end-user preclinical validation, and three research-oriented SMEs in biotechnology, nanosensing and microfluidics.

NAIMO • • •

Acronym: NAIMO Project Title: NAnoscale Integrated processing of self-organizing Multifunctional Organic Materials Participants:



Project Abstract: Short description : NAIMO will develop new multifunctional materials that are processed by solution-based additive manufacturing (e.g. direct printing), under quasi-ambient conditions, so that a set of materials can be added onto a wide range of structural substrates, to form a composite material with designed multifunctionality in an environmentally-friendly way. A key outcome of NAIMO will be the set of materials, process and manufacturing capabilities to transform a plastic film substrate into a multifunctional composite (with designed electronic, optical, sensing and magnetic capabilities) by a series of additive manufacturing steps. This solution-based manufacturing approach will enable control of structure on a nanometre scale. NAIMO will build on the important advances made by the Partners in the use of molecular materials (including conjugated polymers) for low-cost large-area electronic and optical applications. Major impacts : 1) NAIMO will create the scientific and technological foundations and the societal environment needed to create a new industry of thin-film multifunctional materials. 2) The NAIMO research program is anticipated to lead to major fundamental advances in materials design, synthesis, process techniques and manufacturing tools. 3) Besides improving the competitiveness of European industry, NAIMO will also contribute to the development of new products, such as organic electronic integrated circuits and displays, sensors, flexible solar cells, and magnetic structures that will directly benefits to the health, welfare, security and environment of the European citizens.

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AVECIA LIMITED (AVECIA), www.avecia.com , (UK) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO (HOLST), www.tno.nl , (NL) INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW (IMEC), www.imec.be , (BE) INNOVA SPA (INNOVA), www.innova-eu.net , (IT) CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI (INSTM-UNIBO), www.instm.it , (IT) JOHNSON MATTHEY PLC. (JMTC), www.matthey.com , (UK) LINKOPINGS UNIVERSITET (LIU), , (SE) MARTEC CONSULTING SPRL (MARTEC), www.martec-consulting.com , (BE) MERCK KGAA (MERCK), www.merck.de , (DE) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) PHILIPS ELECTRONICS NEDERLAND B.V. (PHILIPS RESEARCH), www.philips.com , (NL) PLASTIC LOGIC LIMITED. (PLL), www.plasticlogic.com , (UK) POLITECHNIKA LODZKA (POL), www.p.lodz.pl , (PL) STMICROELECTRONICS SRL (ST-ITALY), www.st.com , (IT) TECHNISCHE UNIVERSITEIT EINDHOVEN (TU/E), www.tue.nl , (NL) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UCAM), www.cam.ac.uk , (UK) UNIVERSITE LIBRE DE BRUXELLES (ULB), www.ulb.ac.be , (BE) UNIVERSITE DE MONS-HAINAUT (UMH), www.umh.ac.be , (BE) JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG (UWUERZ), http://www.uni-wuerzburg.de , (DE)

NAMDIATREAM • • •

Acronym: NAMDIATREAM Project Title: NANOTECHNOLOGICAL TOOLKITS FOR MULTI-MODAL DISEASE DIAGNOSTICS AND TREATMENT MONITORING Participants: – – – – – – – – – – – – – – – – – – – – – –

To be confirmed (AAA), , (FR) AIT Austrian Institute of Technology GmbH (AIT), http://www.ait.ac.at/ , (AT) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (ATI), www.inserm.fr , (FR) To be confirmed (BD), , (BE) To be confirmed (CLX), , (IE) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) To be confirmed (FEE), , (DE) INNOVA SPA (INN), www.innova-eu.net , (IT) INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE INSAT (INSAT), www.insa-toulouse.fr , (FR) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) Asociacion - Centro de Investigacion Cooperativa en Nanociencias - CIC NANOGUNE (nanoGune), www.nanogune.eu , (ES) To be confirmed (NIF), , (FR) To be confirmed (NS), , (UK) To be confirmed (PGK), , (ES) PHILIPPS UNIVERSITAET MARBURG (PUM), www.uni-marburg.de , (DE) Radisens Diagnostics Limited (RDS), www.radisens.com , (IE) Selective Antibodies Limited (SAL), http://selectiveantibodies.com/www/ , (UK) THE PROVOST FELLOWS & SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (TCD), www.tcd.ie , (IE) TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (TUBS), www.tu-braunschweig.de , (DE) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (UCD), www.ucd.ie , (IE) To be confirmed (UdS), , (FR) UNIVERSITE DE GENEVE (UNIGE), www.unige.ch , (CH)

NAMDIATREAM cont. •

Project Abstract: NAMDIATREAM will develop a cutting edge nanotechnology-based toolkit for multi-modal detection of biomarkers of most common cancer types and cancer metastases, permitting identification of cells indicative of early disease onset in a high-specificity and throughput format in clinical, laboratory and point-ofcare devices. The project is built on the innovative concepts of super-sensitive and highly specific “lab-on-a-bead”, “lab-on-achip” and “lab-on-a-wire” nano-devices utilizing photoluminescent, plasmonic, magnetic and non-linear optical properties of nanomaterials. This offers groundbreaking advantages over present technologies in terms of stability, sensitivity, time of analysis, probe multiplexing, assay miniaturisation and reproducibility. The ETP in Nanomedicine documents point out that nanotechnology has yet to deliver practical solutions for the patients and clinicians in their struggle against common, socially and economically important diseases such as cancer. Over 3.2M new cases and 1.7M cancer-related deaths are registered in Europe every year, largely because diagnostic methods have an insufficient level of sensitivity, limiting their potential for early disease identification. We will deliver -Photoluminescent nanoparticle-based reagents and diagnostic chips for high throughput early diagnosis of cancer and treatment efficiency assessment -Nanocrystals enabling plasmon-optical and nonlinear optical monitoring of molecular receptors within body fluids or on the surface of cancer cell -Multi-Parameter screening of cancer biomarkers in diagnostic material implementing segmented magnetic nanowires -Validation of nano-tools for early diagnosis and highly improved specificity in cancer research. -OECD-compliant nanomaterials with improved stability, signal strength and biocompatibility Direct lead users of the results will be the diagnostic and medical imaging device companies involved in the consortium, clinical and academic partners

NANEX • • •

Acronym: NANEX Project Title: Development of Exposure Scenarios for Manufactured Nanomaterials Participants:



Project Abstract: Nanotechnology is a fast growing industry producing a wide variety of manufactured nanomaterials (MNMs) and numerous potential applications. Consequently, the potential for exposure to humans and the environment is likely to increase. Human exposure to MNMs and environmental release of these materials can occur during all the life cycle stages of these materials. For each stage of the life cycle of an MNM, exposure scenarios will need to be developed that effectively describe how exposure to humans and the environment occur and what measures are required to control the exposure. The aim of the NANEX project is to develop a catalogue of generic and specific (ocupational, consumer and environmental release) exposure scenarios for MNMs taking account of the entire lifecycle of these materials. NANEX will collect and review available exposure information, focussing on three very relevant MNMs: (1) high aspect ratio nanomaterials - HARNs) (e.g. carbon nanotubes); (2) mass-produced nanomaterials (e.g. ZnO, TiO2, carbon black); and (3) specialised nanomaterials that are currently only produced on a small scale (e.g Ag)). The exposure information will include both quantitative (measurement results) and qualitative contextual exposure information (risk management measures). We will also review the applicability of existing models for occupational and consumer exposure assessment and for environmental release from these scenarios. We will carry out a small number of specific case illustrations and carry out a gap analyses of the available knowledge and data. Finally, we project knowledge will be disseminated to relevant stakeholders, taking into account other relevant activities that are taking place in this field.

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COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS" (DEMOKRITOS), www.demokritos.gr , (EL) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) EUROPEAN RESEARCH SERVICES GMBH (ERS), , (DE) INSTITUTE OF OCCUPATIONAL MEDICINE (IOM), www.iom-world.org , (UK) INSTITUT UNIVERSITAIRE ROMAND DE SANTE AU TRAVAIL (IST), www-.i-s-t.ch , (CH) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) FUNDACION LEIA CENTRO DE DESARROLLO TECNOLOGICO (LEIA), www.leia.es , (ES) NANEUM LIMITED (NANEUM), WWW.NANEUM.COM , (UK) NANOCYL S.A. (NANOCYL), www.nanocyl.com , (BE) NANOTECHNOLOGY INDUSTRIES ASSOCIATION (NIA), www.nanotechia.org , (UK) NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO (TNO), www.tno.nl , (NL)

NANO2LIFE • • •

Acronym: NANO2LIFE Project Title: A network for bringing NANOtechnologies TO LIFE Participants: – – – – – – – – – – – – – – – – – – – – – – –

GESELLSCHAFT FUR BIOANALYTIK MUNSTER EV (BIOANALYTIK-MUENSTER), www.bioanalytik-muenster.de , (DE) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) CENTECH GMBH (CENTECH), www.centech.de , (DE) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS" (DEMOK), www.demokritos.gr , (EL) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FHG/IBMT), www.fraunhofer.de , (DE) FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (FORTH - IMBB), www.forth.gr , (EL) FONDATION SUISSE POUR LA RECHERCHE EN MICROTECHNIQUE. (FSRM), www.fsrm.ch , (CH) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (INSERM), www.inserm.fr , (FR) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) LUNDS UNIVERSITET (LUND), www.lu.se , (SE) UNIVERSITEIT TWENTE (MESA+), www.utwente.nl , (NL) NANOBIONET E. V. (NANOBN), www.nanobionet.de , (DE) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (NMRC), www.ucc.ie , (IE) FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA (PCB), www.pcb.ub.es , (ES) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) UNIVERSITY OF NEWCASTLE UPON TYNE (UNEW), www.newcastle.ac.uk , (UK) JOHANNES GUTENBERG UNIVERSITAET MAINZ (UNIMAIN), www.uni-mainz.de , (DE) UNIVERSITAET DES SAARLANDES (UNISAAR), www.uni-saarland.de , (DE) TECHNISCHE UNIVERSITAET KAISERSLAUTERN (UTK), www.uni-kl.de , (DE) WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER (WWU), , (DE)

NANO2LIFE cont. •

Project Abstract: The aim of Nano2Life is to merge existing European expertise and knowledge in the field of nanobiotechnology in order to keep Europe as a competitive partner of the US and Japan and to make it a leader in nanobiotechnology transfer in 4 years time. Nano2Life is tackling fragmentation of European nanobiotech by joining 23 so far unconnected dynamic, highly specialised and competent regions and centres with experience in initiating and running nanobiotech programmes. Nano2Life aims to set the basis of a virtual European Nanobiotech Institute, focused on the understanding of the nanoscale interface between biological and non biological entities, and its possible application in the area of complex and integrated novel sensor technologies, for health care, Pharmaceuticals, environment, defence, food safety, etc. The partners have agreed on a Joint Programme of Activity (JPA) designed: . To develop joint research projects in 4 major technical platforms : functionalisation, handling, detection, integration of devices . To elaborate a joint IPR policy with a special focus on SMEs . To develop novel education and training with special emphasis on the scientific community of the candidate countries . To build a future common RTD platform with shared facilities, knowledge, methods, electronic communications and integrated management. Multi media supported communication and dissemination activities will provide thorough education and awareness of the scientific and industrial community outside of Nano2Life and the general public about the impact of nanobiotech on industry and society. This will ensure development of nanobiotech devices, material and services according to the needs of European industry and in agreement with international social and ethical standards, which will support sustainable development of the European economy in this knowledge intensive area. 175 researchers will be integrated during the 48 months duration

NANO2MARKET • • •

Acronym: NANO2MARKET Project Title: Best Practices for IPR and Technology Transfer in Nanotechnology Developments Participants: – – – – – –

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CAMERA DI COMMERCIO, INDUSTRIA, ARTIGIANATO E AGRICOLTURA DI MILANO (CCIAA), www.mi.camcom.it , (IT) FRANCE INNOVATION SCIENTIFIQUE ET TRANSFERT (FIST SA), http://www.frinnov.fr , (FR) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRA), www.fraunhofer.de , (DE) FUNDACIÓ PRIVADA INSTITUT DE BIOENGINYERIA DE CATALUNYA (IBEC), www.ibecbarcelona.eu , (ES) INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW (IMEC), www.imec.be , (BE) MERMAID VENTURE APS-INVESTORNET GATE2GROWTH DK GATE2FINANCING DK BRABO VENTURES DENMARK (InvestorNet - Brabo Ventures), www.gate2growth.com , (DK) NANOTECHNOLOGY INDUSTRIES ASSOCIATION (NIA), www.nanotechia.org , (UK) FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA (PCB), www.pcb.ub.es , (ES) TECKNOWMETRIX SAS (TKM), , (FR) DE ALICANTE (UA), www.ua.es , (ES)

Project Abstract: The lack of models for technology transfer at nanotechnology developments is of increasing concern for the sector. This CSA will fulfil this gap providing guidelines for technology transfer and rules for IPR and license agreements in nanotechnology developments. To achieve these objectives, a consortium is formed by: 1) Key European research centres in different areas of nano and converging technologies, 2) Outstanding agencies for IPR advice, 3) Market analyst experts,industry associations and venture capitals, as end clients of IP. Constructing value chains of the transfer of each technology the consortium will analyse specific applications of the different areas of the nanotechnology R&D European strategy: medical applications, information technologies, energy, materials, manufacturing, instrumentation, food, environment and security. Our objective is to classify the technology application areas of nanotechnology into different clusters according to: development costs, market time, complexity of licensing, etc. In parallel, a mapping of the technology and actual and forthcoming market will be analysed according to: competitiveness, geographical area, development potential, risks etc. Specific data mining tools will help to conclude the key worldwide actors of development and commercialisation of the different technologies. Also, actual IPR cultures and technology transfer rules will be listed according to the features of their market and technology. Matching these IPR technology transfer models with the concluded value chains and market and technology mapping, will allow concluding business models and setting efficient rules for technology transfer. All models will be discussed at consortium seminars, where general algorithms are expected to be excerpted. Specific guidelines will be given for research institutions and SMEs for efficient transfer of their prototypes to the market, along with a focus for the valorization of EU FP7 funded research projects

NANO3D • • •



Acronym: NANO3D Project Title: Precision Chemical Nanoengineering: Integrating Top-Down and Bottom-Up Methodologies for the Fabrication of 3-D Adaptive Nanostructured Architectures Participants: – – – – – – –

BAE SYSTEMS (OPERATIONS) LIMITED (BAES-ATC), www.baesystems.com , (UK) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (NMRC-UCC), www.ucc.ie , (IE) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (NUID/UCD), www.ucd.ie , (IE) 9D TECHNOLOGIES SARL (TT), , (CH) THE UNIVERSITY OF BIRMINGHAM (UOB), www.bham.ac.uk , (UK)

Project Abstract: The overall objective of the research proposed in this document is to integrate top-down lithographic techniques which enable precise spatial patterning of surfaces from micron- to the nanoscale, with the controlled stepwise self-assembly and self-organisation of nanometer scale chemical and biochemical entities to these surfaces, to fabricate three dimensional (3D) adaptive nanostructured architectures, which have demonstratable uses, in a fashion that will allow the processes to be scaled into proto-type production methodologies. The Nano3D consortia wish to be the first to demonstrate that nanostructures on surfaces can be created via an integration of top-down and bottom-up methodologies, by the self-organisation of self-assembled molecular building blocks on nanopatterned surfaces, such that the nanostructures are able to adapt to the environment. Furthermore, the Nano3D consortia wish to further innovate in illustrating that this approach can be scaled up into a proto-type production process, such that automation and scaleability can be demonstrated. The Nano3D consortia will be innovating a new paradigm for manufacturing nanostructures on surfaces. The Nano3D proposal addresses Community socio-economic objectives from many view points. In response to the need for the transformation of industry towards higher-added value activities, one of the central objectives of the consortium is to develop new knowledge targeted towards high value-added technologies, including biotechnology, biomedicine and ICT. Successful innovations will ultimately enable new product and market development that will stimulate employment opportunities. Perhaps more relevantly, if Europe does not take its rightful place at the centre stage of emerging nanotechnology research and development for these technologies, then these industries in Europe will continue to lose market share to new competing technologies from the Americas and the Far East.

NANO3T • • •

Acronym: NANO3T Project Title: Biofunctionalized Metal and Magnetic Nanoparticles for Targeted Tumor Therapy Participants: – – –

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AARHUS UNIVERSITET (AU), www.au.dk , (DK) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (Fraunhofer), www.fraunhofer.de , (DE) Karlsruher Institut fuer Technologie (FZK), www.kit.edu , (DE) INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW (IMEC), www.imec.be , (BE) IMEGO AB (IMEGO), www.imego.com , (SE) INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V (IPHT), www.ipht-jena.de , (DE) PEPSCAN THERAPEUTICS BV (PEPSCAN), www.pepscan.com , (NL)

Project Abstract: The cause of diseases is often unknown, but their origin can frequently be found at the biomolecular and cellular level situated on nm-scale. Early diagnostics combined with early intervention on that nanoscale is one of the holy grail of modern medicine. Inorganic nanoparticles are very promising agents in that respect. One of the promising biomedical applications of these nanoparticles is their use as agents for tumor hyperthermia. Hyperthermia is a form of cancer treatment that uses an elevated temperature to kill the tumor tissue. Compared to the more conventional surgical procedures, it is hailed as a less invasive approach that could be used for small, non-defined tumors. Well-designed instrumentation in combination with engineered inorganic nanoparticles that (a) possess the desired physical properties to generate a local heat and that (b) can specifically target the tumor offer immense potentials for targeted hyperthermia therapy. The overall objective of the present multi-disciplinary project is to develop and to explore various metal/magnetic nanoparticles as agents for targeted tumor therapy. To strive for this overall objective, a successful integration and convergence of different technologies at the nanoscale is indispensable. In this project, we will focus on the synthesis routes of tailor designed biofunctionalized nanoparticles for hyperthermia. This requires a profound physical and chemical characterization of the synthesized nanostructures, but the project is certainly not limited hereto. It will also include a toxicological and biological evaluation of the different nanoparticles. Hereby a detailed exploration and characterization of the interaction mechanism of the biological entities and the nanostructures will be pursued to obtain a better understanding of the phenomena occurring at the nanoscale. In addition, this project also comprises the design of advanced instrumentation that can be used for a controlled hyperthermia treatment.

NANO DIALOGUE • • •

Acronym: NANO DIALOGUE Project Title: Enhancing dialogue on nanotechnologies and nanosciences in society at the European level Participants:



Project Abstract: The NANO DIALOGUE project will establish an integrated process of communication and social debate about nanotechnologies and nanosciences (NN) at European level. The proponent consortium is composed of organisations of excellence in different fields, integrating different competences (scientific research, social participation, science communication) and representing a wide European dimension. These elements will allow a high quality of communication tools and methodologies as well as widespread diffusion of the results. Even though NN are key-issues for the next future (for biomedical applications, telecommunication, new materials,...), they are still not well known and understood at large. The project aims firstly at providing information and raising awareness among the general public on the last developments of research in this field. Secondly, at implementing social dialogue between the research community, citizens and other social actors in order to identify main issues and expectations from these groups. Among the expected results is to provide the EC and experts with recommendations, illustrating the main social concerns about NN. Research in NN is yet at an early stage; so the need for information is the starting point for public debate and for social participation on their future developments. This will be achieved through the definition of scientific guidelines in a European meeting and the establishment of a Scientific Advisory Board the organisation of a participatory workshop with the involvement of scientists, decision makers and stakeholders who'll work together to elaborate a common synopsis for communication tools; the production of 8 exhibition modules and a web site including specific tools for collecting data on citizens expectations; the organisation of exhibitions and events in 8 participating countries during 6 months at least; a European Conference targeted to relevant experts, decision makers and stakeholders.

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SIHTASUTUS TEADUSKESKUS AHHAA (AHHAA), www.ahhaa.ee , (EE) CENTRE CULTUREL SCIENTIFIQUE ET TECHNIQUE (CCSTI), www.ccsti-grenoble.org , (FR) CIENCIA VIVA-AGENCIA NACIONAL PARA A CULTURA CIENTIFICA E TECNOLOGICA (CIêNCIA VIVA), www.pavconhecimento.pt , (PT) DEUTSCHES MUSEUM VON MEISTERWERKEN DER NATURWISSENSCHAFT UND TECHNIK (DM), www.deutsches-museum.de , (DE) ASSOCIATION EUROPéENNE DES EXPOSITIONS SCIENTIFIQUES, TECHNIQUES ET INDUSTRIELLES (ECSITE), www.ecsite.net , (BE) FLANDERS TECHNOLOGY INTERNATIONAL (F.T.I. FOUNDATION), www.technopolis.be , (BE) FONDAZIONE IDIS-CITTà DELLA SCIENZA (IDIS), www.cittadellascienza.it , (IT) ASSOCIAZIONE MACROSCOPIC QUANTUM COHERENCE AND COMPUTING (MQC2), www.mqc2.it , (IT) FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA (PCB), www.pcb.ub.es , (ES) UNIVERSEUM AB (UNIVERSEUM), www.universeum.se , (SE) THE UNIVERSITY OF WESTMINSTER (UOW), , (UK)

NANO ROAD SME • • •



Acronym: NANO ROAD SME Project Title: Development of Advanced Technology Roadmaps in Nanomaterial Sciences and Industrial Adaptation to Small and Medium sized Enterprises Participants: – – – – – – – – – – – –

CHAMBRE REGIONALE DE COMMERCE ET D'INDUSTRIE DE BOURGOGNE (ARIST-CRCI BOURGOGNE), www.bourgogne.cci.fr , (FR) COMITE RICHELIEU (CR), www.comite-richelieu.com , (FR) OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH (FFG), www.ffg.at , (AT) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FHG), www.fraunhofer.de , (DE) FORSCHUNGSZENTRUM KARLSRUHE GMBH (FZK), www.fzk.de , (DE) MALSCH TECHNOVALUATION (MTV), www.malsch.demon.nl , (NL) STEINBEIS-STIFTUNG FUER WIRTSCHAFTSFOERDERUNG. (SEZ), www.steinbeis-europa.de , (DE) STICHTING SYNTENS, INNOVATIENETWERK VOOR ONDERNEMERS (SYNTENS), www.syntens.nl , (NL) COMPLUTENSE DE MADRID (UCM), , (ES) INSTYTUT WYSOKICH CISNIEN - POLSKIEJ AKADEMII NAUK (UNIPRESS), www.unipress.waw.pl , (PL) POLITECNICA DE MADRID (UPM), www.upm.es , (ES) VALTION TEKNILLINEN TUTKIMUSKESKUS (VTT), www.vtt.fi , (FI)

Project Abstract: In the next ten years scientific developments in the field of nanomaterials will influence many different industrial branches e.g. automotive, aeronautics, mechanical engineering, medical systems or health. In these industrial sectors many SMEs are involved as traditional suppliers, start-ups or producers of high tech products. In order to remain competitive on these markets, the companies have to integrate these new results in their commercial vision for future products. The project NANO ROAD SME will develop technology roadmaps in the domain of nanomaterials comprising the latest high level scientific results by using a dynamic and holistic approach. Their functions will be to identify trends in research and development and to associate them to product and application visions. They will outline, which of them are technically and economically promising or possess high potentials for problem-solving and where potential risks and relevant investigation requirements are assumed or social discussion requirement could prevail. In a second step these roadmaps will be adapted to the SME industrial culture in order to facilitate the integration of the European RTD results for nanomaterials in the different industrial branches. The project involves well-known European research organisations and networks, which are leaders in the domain of nanomaterials, European experts in the development of technology roadmaps and organisations specialised in the knowledge transfer to the industry and especially to SMEs. The project has a large European dimension. It involves 12 organisations from 7 European countries including one Candidate country. The project "Nano Road SME" is a pilot initiative which will develop technology roadmaps and use them to facilitate the transfer and integration of European RTD results from the nanotechnological field (especially nanomaterials) to SMEs.

NANOBEAMS • •

Acronym: NANOBEAMS Project Title: Nanoanalysis using finely focused ion and electron beams



Participants: – – – – – – – – – – – –

CAMECA S.A.S. (CAMECA), www.cameca.fr , (FR) CENTRE DE RECHERCHE PUBLIC - GABRIEL LIPPMANN (CRP-GL), www.lippmann.lu , (LU) FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR (FUNDP), www.fundp.ac.be , (BE) ION-TOF TECHNOLOGIES GMBH (ION-TOF), www.iontof.com , (DE) ORSAY PHYSICS S.A. (OP), www.orsayphysics.com , (FR) RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN (RWTH), www.rwth-aachen.de , (DE) VG SYSTEMS LIMITED (TE), , (UK) UNIVERSITEIT ANTWERPEN (UA), www.ua.ac.be , (BE) UNIVERSITE CATHOLIQUE DE LOUVAIN (UCL), www.uclouvain.be , (BE) WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER (UMSR), , (DE) UNIVERSITE DE ROUEN (UNIV OF ROUEN), www.univ-rouen.fr , (FR) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD (UOXF.DJ), www.ox.ac.uk , (UK)

NANOBEAMS cont. •

Project Abstract: In order to match the resolution required for the development of nanomaterials and provide analytical information, this NoE concentrates on analytical techniques using focused ion and electron beams: SIMS /AES /TEM European industries have a leadership in this field: - the world leader for D-SIMS is a French SME (Cameca) - amongst the two producers of S-SIMS one is a German SME (ION-TOF) - one of the 3 producers of AES is in England (TE), - analytical TEM equipment is produced by 1 German, 1 Dutch and 1 Japanese company. The European academic labs played a major role in the development of these techniques. This NoE will bring together the manufacturers mentioned above in brackets as well as the leading scientists and users in the academic labs. The partners will perform 9 INTEGRATING ACTIVITIES during the project. The 4 main activities will consist in the coordination of instrumental development, of fundamental research, the application to nanomaterials and the coordination of manufacturers. In addition to these topics, 5 further such integrating activities will be installed to cover aspects as research tools and infrastructures, personnel, management of knowledge and intellectual property and communication network. 5 further integrating activities will cover aspects as research tools and infrastructures, personnel, management of knowledge and intellectual property and communication network. This NoE will integrate 7 RESEARCH ACTIVITIES: - new ion sources for SIMS - development of new techniques - investigation of biological specimens for UHV experiments and analysis - analysis of layered, and - of 2 and 3D nanomaterials - formation process of atomic and molecular ions under ion bombardment - analytical chemistry in S- and D-SIMS The NoE will create a European workshop about these analytical techniques, a European PhD school, 2 working groups for applications in biology and material science, as well as training courses.

NANOBIOPHARMACEUTICS • • •

Acronym: NANOBIOPHARMACEUTICS Project Title: Nanoscale Functionalities for Targeted Drug Delivery of Biopharmaceutics Participants: – – – – – – – – – – – – – – – – – – – – – – – – – – –

APLAGEN GMBH (APLA), www.aplagen.com , (DE) CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS (CERTH/CPERI), WWW.CERTH.GR , (EL) CHALMERS TEKNISKA HOEGSKOLA AB (CHALMERS), www.chalmers.se , (SE) CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH POLSKIEJ AKADEMII NAUK (CMMS PAS), www.cbmm.lodz.pl , (PL) DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V. (DECHEMA E.V.), www.dechema.de , (DE) DWI AN DER RWTH AACHEN EV (DWI/RWTH), www.dwi.rwth-aachen.de , (DE) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) GLAXOSMITHKLINE BIOLOGICALS (GSK BIO), www.gskbio.com , (BE) INSTITUT QUIMIC DE SARRIA (IQS), www.iqs.edu , (ES) JOHANNES GUTENBERG UNIVERSITAET MAINZ (JGU), www.uni-mainz.de , (DE) JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH (JOANNEUM), www.joanneum.at , (AT) LEK FARMACEVTSKA DRUZBA DD*LEK PHAR MACEUTICALS DD SOCIETE PHARMACEUTIQ UE LEK DD (LEK D.D.), www.lek.si , (SI) LIPOXEN TECHNOLOGIES LIMITED (LITEC), www.lipoxen.com , (UK) MAGNAMEDICS GMBH (MM), www.magnamedics.com , (DE) MEDIZINISCHE UNIVERSITAET GRAZ (MUG), http://www.medunigraz.at , (AT) NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS" (NCSR DEMOKRITOS), www.demokritos.gr , (EL) KEMIJSKI INSTITUT (NIC), http://www.ki.si , (SI) NOVO NORDISK A/S (NOVO), www.novonordisk.com , (DK) REGULON AE (REGULON), www.regulon.org , (EL) SUSTECH GMBH & CO. KG (SUSTECH), www.sustech.de , (DE) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) THIOMATRIX FORSCHUNGS- UND BERATUNGS GMBH (THIOMATRIX), www.thiomatrix.com , (AT) UNIVERSITEIT TWENTE (TWENTE), www.utwente.nl , (NL) UNIVERSITAET INNSBRUCK (UIBK), http://www.uibk.ac.at , (AT) UNIVERSITE DE LIEGE (ULG), www.ulg.ac.be , (BE) UNIVERSITEIT MAASTRICHT (UM), http://www.maastrichtuniversity.nl , (NL) UNIVERSITA DEGLI STUDI DI TRIESTE (UNITS), www.units.it , (IT)

NANOBIOPHARMACEUTICS cont. •

Project Abstract: The Integrated Project NanoBioPharmaceutics aims at the development of innovative multidisciplinary approaches for the design, synthesis and evaluation of functionalized nanocarriers and nanoparticle-based microcarriers for the treatment of various diseases based on targeted, controlled delivery of therapeutic peptides and proteins (biopharmaceutics). More specifically, the present IP aims at the following scientific and technological objectives: 1. Design, synthesis and functionalization of novel nanocarriers and nanoparticle-based microcarriers for targeted delivery of P/P drugs via oral, pulmonary and Blood Brain Barrier (BBB) crossing administration routes. 2. Toxicological screening of the nanocarriers and investigation of the release profile of P/P drug under various environmental conditions and the assessment of the biocompatibility and biodegradability of the new formulations. 3. Novel pulmonary P/P carriers with improved delivery features to overcome the administration difficulties and increase efficiency of protein delivery to the deep lung. 4. Oral nanoparticulate P/P carrier systems capable of adhering to the gastrointestinal mucosa and also displaying protective and permeation enhancing properties. 5. Establishment of an in vitro model for the assessment of nanocarriers permeability through the Blood Brain Barrier (BBB). The present IP integrates the scientific activities and complementary skills of researchers coming from 13 EU countries and the state of Israel, in an attempt to ensure breakthrough advances in novel biopharmaceutics delivery systems. The Consortium consists of 12 University departments, 6 research institutes, 6 SMEs and 3 large industries. An efficient management scheme has been established to ensure the fulfillment of the IP?s scientific, technological and exploitation objectives.

NANOBIOTACT • • •

Acronym: NANOBIOTACT Project Title: Nano-engineering biomimetic tactile sensors Participants: –

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C3M DOO, CENTER ZA RACUNALNISTVO VMEHANIKI KONTINUUMA - MODELIRANJE IN TRZENJE (C3M D.O.O.), www.c3m.si , (SI) ROCKFIELD SOFTWARE LIMITED (ROCKFIELD), www.rockfield.co.uk , (UK) SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA (SSSA), , (IT) TECHNISCHE UNIVERSITAET MUENCHEN (TUM), www.tu-muenchen.de , (DE) THE UNIVERSITY OF BIRMINGHAM (UB), www.bham.ac.uk , (UK) UNIVERSITE CATHOLIQUE DE LOUVAIN (UCL), www.uclouvain.be , (BE) GOETEBORGS UNIVERSITET (UGOT), www.gu.se , (SE) UNILEVER UK CENTRAL RESOURCES LIMITED (UNILEVER), www.unilever.com , (UK)

Project Abstract: The objective is to design and construct an articulated artificial finger with a biomimetic sensor based on an array of NEMS force transducers that will mimic the spatial resolution, sensitivity and dynamics of human tactile neural sensors. This will require the development of the scientific understanding of these mechanoreceptors and the neural coding of the many thousands of action potentials that are discharged during a tactile experience. Experts will be brought together working at the frontiers of knowledge in nanotechnology, psychology, neurology, cognitive science, skin mechanics, robotics, tissue engineering, numerical simulation and information processing. Tactile stimuli will be assessed using physchophysical, neurophysiological and brain imaging techniques. A virtual model of the tactile process will be developed to enable the neurophysiological response of a virtual stimulus to be computed. The information from the psychophysical, neurophysiological, neuroimaging and computer simulation activities will be processed using artificial recurrent neural networks. This will lead to an improved description of the neural coding for taction, such as texture recognition, and lead to design strategies for the MEMS arrays based on advanced optimisation techniques. Biomimetic tactile sensors have many applications, for example, prosthetic limbs with neural interfaced sensing and control, robotics with controlled grip and for haptic exploration, tele-activities (eg remote surgery) and virtual reality training environments. Moreover, an improved understanding of the human tactile system will assist in the treatment of patients with impaired neurological function. The design of new products will be revolutionised, by being able to more effectively exploit rapid virtual prototyping and high throughput screening techniques, for example, in sectors such as personal care, sports, textiles and laundry products and for automobiles

NANOBIOTOUCH • • •

Acronym: NANOBIOTOUCH Project Title: Nano-resolved multi-scale investigations of human tactile sensations and tissue engineered nanobiosensors Participants:



Project Abstract: The main scientific aims are to radically improve understanding of the human mechanotransduction system and tissue engineered nanobiosensors. This will be achieved through systematic integration of new developments from converging scientific areas by involving academic and industrial participants who are experts in cognitive sciences, microneurography, brain imaging, cell biology and mechanics, tissue engineering, skin physics (tribology and mechanics), microengineering, multi-scale multi-physics modelling, information processing, robotics, prosthetics and medical rehabilitation. The project will build on existing discriminative touch research in order to understand affective touch mediated by the human fingerpad. Sensors capable of detecting directional force and temperature will be developed since a combination of these modalities is critical to the affective component of the neurophysiological response evoked in taction. This next generation of sensors will include NEMS arrays and hybrid bio-NEMS systems. They will be integrated into a robotic finger with articulation controlled by neural network information processing that will allow artificial exploration of a surface to be achieved in ways that mimic human haptic behaviour and affective response. The impact of the project will include alleviating the effects of human touch and vision disabilities, improving the quality of life, security printing, brand protection, smart packaging, space exploration and also the evaluation of products such as textiles and skin creams using the instrumented robotic finger. The consortium includes industrial participants who will undertake specific technical exploitation activities in order to maximise the commercial impact of the research.

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COURAGE + KHAZAKA ELECTRONIC GMBH (CKE), , (DE) SCUOLA UNIVERSITARIA PROFESSIONALE DELLA SVIZZERA ITALIANA (SUPSI) (IDSIA-SUPSI), , (CH) Optaglio s.r.o. (OPT), www.optaglio.cz , (CZ) ROCKFIELD SOFTWARE LIMITED (RSL), www.rockfield.co.uk , (UK) SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA (SSSA), , (IT) THE UNIVERSITY OF BIRMINGHAM (UB), www.bham.ac.uk , (UK) UNIVERSITE CATHOLIQUE DE LOUVAIN (UCL), www.uclouvain.be , (BE) GOETEBORGS UNIVERSITET (UG), www.gu.se , (SE) UNIVERZA V LJUBLJANI (UL), http://www.uni-lj.si , (SI) UNILEVER UK CENTRAL RESOURCES LIMITED (UNL), www.unilever.com , (UK) SWANSEA UNIVERSITY (UW), , (UK) C3M DOO, CENTER ZA RACUNALNISTVO VMEHANIKI KONTINUUMA - MODELIRANJE IN TRZENJE (C3M), www.c3m.si , (SI)

NANOCAPS • • •

Acronym: NANOCAPS Project Title: Nanocapsules for Targeted Controlled Delivery of Chemicals Participants:



Project Abstract: The project NANOCAPS will develop new technologies based on microencapsulation to solve industrial problems related to controlled release of chemicals. The technical objectives are to develop nanomaterials and nanocomposite coatings for cost-efficient production of nanocapsules and, to validate the technical and economical feasibility of the knowledge acquired in the fields of biomedical (anti-proliferating and anti-allergic agents) and metal plating (self repair) applications. NANOCAPS will greatly contribute to the environment policy in Europe and to improve the quality of life of people (health). To achieve the objectives, NANOCAPS has been configured in five main activities (WP) addressing specific problems. Two of these are technology oriented (WP1 and WP2), and concern the production of nanomaterials as capsule core and shell. Two others are directed basic research (WP3 and WP4), and consider fundamental studies on the reactivity of the core materials and the capsules, and the development of new advanced methods for the characterisation of nanocapsules. The fifth activity considers the validation and exploitation of the knowledge in multisectorial industrial prototypes. The industrial end-users define the active molecules and the components of the capsules. The Universities and Research Centres will study the basic properties, and together they will develop the process and synthesis of capsule core and shell. Finally, the project will make a validation of the system and the process developed, with mobile test units for targeted applications. The objectives of NANOCAPS are relevant for the Topic 3.4.2.3-1 of NMP-3 due to the novel technologies used for building nanoengineered ultrathin layers and nanoparticles as capsule components, but are also relevant for the Topic 3.4.3.1-1 due to the development of new technologies for manufacturing micro- and nanocapsules, and for the topic 3.4.1.1-2 due to the construction of the capsule shell.

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CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS (CERTH), WWW.CERTH.GR , (EL) COATEX SAS (COATEX), www.coatex.fr/ , (FR) COVENTYA SAS (COVENTYA), www.coventya.com , (FR) ICB PHARMA S.J. (ICB POLAND), www.allergoff.pl , (PL) INSTYTUT KATALIZY I FIZYKOCHEMII POWIERZCHNI, POLSKA AKADEMIA NAUK (ICSC), http://www.ik-pan.krakow.pl , (PL) IFP-INSTITUT FRANCAIS DU PETROLE (IFP), www.ifp.fr , (FR) KERANOR AS (KERANOR), www.keranor.no , (NO) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPIKG), www.mpg.de , (DE) PLASMACHEM PRODUKTIONS- UND HANDELGMBH (PLASMACHEM), http://www.plasmachem.com , (DE) STIFTELSEN SINTEF (SINTEF), www.sintef.no , (NO) UNIVERSITE DE FRANCHE-COMTE (UFC), , (FR)

NANOCHEMSENS • • •

Acronym: NANOCHEMSENS Project Title: Nanostructures for Chemical Sensors Participants:



Project Abstract: The project "Nanostructures for Chemical Sensors" (NanoChemSens) is pertaining to the identification and development of the appropriate surface science tools and nanotechnological processes of future nanodevices for chemical sensing by understanding those nano-scale phenomena that control nanostructured sensors and functionalized surfaces.The first objective of the project is the development of suitable techniques for atomically controlled fabrication of nanostructured sensors ("Processing of sensor nanostructures and functionalized surfaces"). The second objective is to extend our understanding of length scales and complexity of phenomena and processes of relevance for chemical sensors and sensor/molecule interactions on functionalized surfaces having sensitive structures of nanosize dimension ("Fundamental studies and new concepts on sensor nanostructures and functionalized surfaces"). The third objective is to test the performed sensor abilities and to develop potential routes from fundamental studies to sensor development for nanostructured sensors ("Control of the properties of processed sensor nanostructures and functionalized surfaces"). Four selected material systems will be investigated. -Rutile-phase titanium dioxide (TiO2) with nanosized metal clusters and nanowires of metals (Pt, Pd), nanosized MoOx particles, and p-type conducting Cr1.8Ti0.2O3 particles -Heteroepitaxial ultrathin structures of CuO/ZnO/AI2O3 -n-conducting tungsten oxide (W03) -Organic molecules (Cu-phthalocyanine, 3,4,9,10-perlenetetracarboxylic dianhydride and oligophenylene-vinylene) on ZnO and TiO2 single crystals and on heteroepitaxial ZnO/Al2O3 films. These materials are chosen with respect to their applicability in sensors, the level at which they are well characterized by surface science studies and their potential to develop a suitable nanotechnological processing.

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BERNT GMBH (BER), www.berntgmbh.de , (DE) UNIVERSITE DE BOURGOGNE (BOU), www.u-bourgogne.fr , (FR) DANISH MICRO ENGINEERING A/S (DME), www.dme-spm.dk , (DK) FORCE TECHNOLOGY (FOR), http://www.force.dk , (DK) UNIVERSITA DEGLI STUDI DI PADOVA (PAD), www.unipd.it , (IT) PBI-DANSENSOR A/S (PBI), www.pbi-dansensor.com , (DK) UNIVERZITA KARLOVA V PRAZE (PRA), www.cuni.cz , (CZ) ROSKILDE UNIVERSITETSCENTER. (RUC), www.ruc.dk , (DK) UNIVERSITY COLLEGE LONDON (UCL), http://www.ucl.ac.uk , (UK) UNIVERSITE PAUL CEZANNE AIX MARSEILLE III (UDESAM), www.univ-cezanne.fr , (FR) HEINRICH-HEINE-UNIVERSITAET DUESSELDORF (UDUS), , (DE) KøBENHAVNS UNIVERSITET (UKBH), www.ku.dk , (DK) VEGATEC (VEG), www.vegatec.com , (FR)

NANOCOM • • •

Acronym: NANOCOM Project Title: Lowering Barriers for Nanotechnology Commercialisation via Open Innovation Participants:



Project Abstract: The NanoCom coordinated action will contribute to bridging the gap between lab based and industrial applications in nanotechnology by creating a European wide approach and mechanisms for lowering the barriers and spreading best open innovation practices for rapid commercialisation and investment in innovative nanotechnology driven products. The vision will be supported by the following key objectives: • To carry out a critical analysis of barriers for rapid commercialisation of emerging Micro and Nano Technologies (MNT) that result from many complementary EC, national and industrially funded Research and Development (R&D) projects • To analyse and promote best practices via new nanotechnology and nano-manufacturing specific open innovation methodology and tools and provide roadmapping, policy and investment advise at EU, national and regional levels • To create a commercialisation oriented forum and mechanisms for coordinating the efforts of many complementary R&D projects in ERA • To provide support for training and dissemination of best practices for open innovation and commercialisation of nanotechnology. The NanoCom outcomes will target the creation of new Open Innovation approach and support environment for overcoming the barriers to commercialisation of nanotechnology results in Europe and promoting and spreading best practices. The results of the project will dramatically increase the uptake of nanotechnologies and facilitate the development of a strong and thriving European nano-manufacturing sector providing global innovation leadership in the field.

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ACCIONA INFRAESTRUCTURAS S.A. (Acciona), acciona-infraestructuras.es , (ES) BAYER TECHNOLOGY SERVICES GMBH (Bayer), www.bayertechnology.com , (DE) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) Centre for Process Innovation Limited (CPI), www.uk-cpi.com , (UK) CENTRO RICERCHE FIAT SCPA (CRF), www.crf.it , (IT) CULMINATUM INNOVATION OY LTD (Culminatum), http://www.culminatum.fi , (FI) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (Fraunhofer), www.fraunhofer.de , (DE) INNOBRIDGE SA (Innobridge), www.innobridge.com , (CH) Karlsruher Institut fuer Technologie (KIFT), www.kit.edu , (DE) LUX RESEARCH INC. (LUX), www.luxresearchinc.com , (US) NANOTRADE SRO (Nanotrade), www.nanotrade.cz , (CZ) NINESIGMA EUROPE BVBA (NineSigma), www.ninesigma.com , (BE) PLASTIPOLIS (Plastipolis), www.plastipolis.fr , (FR) RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN (RWTH), www.rwth-aachen.de , (DE) THE UNIVERSITY OF NOTTINGHAM (UN), www.nottingham.ac.uk , (UK) VENETO NANOTECH SCPA (Veneto Nanotech), www.venetonanotech.it , (IT)

NANOCUES • • •

Acronym: NANOCUES Project Title: Nanoscale surface cues to steer cellular biosystems Participants: – – – – – – –



CHALMERS TEKNISKA HOEGSKOLA AB (CHALMERS), www.chalmers.se , (SE) EIDGENöSSISCHE TECHNISCHE HOCHSCHULE ZüRICH (ETH), www.ethz.ch , (CH) KAROLINSKA INSTITUTET (KI), www.ki.se , (SE) AARHUS UNIVERSITET (UAAR), www.au.dk , (DK) UNIVERSITE DE BORDEAUX I (U-BDX1), www.u-bordeaux1.fr , (FR) UNIVERSITY OF GLASGOW (UG), www.gla.ac.uk , (UK) RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG. (UHD), www.uni-heidelberg.de , (DE)

Project Abstract: The overall Science and Technology (S&T) objectives of this project are to create a knowledge base and a technical platform that can be exploited in the design and development of nanobiotechnological processes and devices, tailored to steer/monitor cellular function. The project team consists of 7 leading groups in Europe, representing the necessary interdisciplinary competence and the complementarity required for this purpose. The project includes all levels from materials design and preparation, nanostructuring, chemical patterning, and biomolecular interactions up to the cellular level. There are a number of obstacles which currently prevent a knowledge base and a technical platform from being realised. Some relate to the lack of suitable fabrication methods e.g. to produce nanopatterned non-fouling surfaces with functional arrays of macromolecules, some relate to a lack of suitable characterisation tools e.g. tools to characterize the interface between living cells and synthetic materials, others relate to a lack of understanding of molecular interactions at surfaces and of mechanisms of cellular interactions at biointerfaces. The scientific and technical work plan addresses critical issues of the different types (fabrication, characterisation and understanding of molecular and cellular interactions. The main deliverables from this project will be i) new fabrication tools for nano-scale patterned surfaces, ii) new characterisation tools, and iii) knowledge generated of the interaction of biological systems components with nano-scale patterns and structures. This outcome will provide a platform for the design and implementation for directing cellular function via surface nano-scale molecular cues.

NANODEVICE • • •

Acronym: NANODEVICE Project Title: Novel Concepts, Methods, and Technologies for the Production of Portable, Easy-to-Use Devices for the Measurement and Analysis of Airborne Engineered Nanoparticles in Workplace Air Participants: – – – – – – – – – – – – – – – – – – – – – – – – – –

BASF SE (BASF), www.basf.com , (DE) BUNDESANSTALT FUER ARBEITSSCHUTZ UND ARBEITSMEDIZIN (BAuA), http://www.baua.de , (DE) CENTRALNY INSTYTUT OCHRONY PRACY - PANSTWOWY INSTYTUT BADAWCZY (CIOP-PIB), www.ciop.pl , (PL) DEKATI OY (DEKATI), www.dekati.fi , (FI) DEUTSCHE GESETZLICHE UNFALLVERSICHERUNG (DGUV-BGIA), , (DE) DET NORSKE VERITAS AS (DNV), www.dnv.com , (NO) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) EUROPEAN VIRTUAL INSTITUTE FOR INTEGRATED RISK MANAGEMENT (EU-VRi), , (DE) TYOETERVEYSLAITOS. (FIOH), www.ttl.fi , (FI) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (Fraunhofer), www.fraunhofer.de , (DE) GRIMM AEROSOL TECHNIK Gmbh & Co KG (GRIMM), www.grimm-aerosol.com , (DE) HEALTH AND SAFETY EXECUTIVE (HSE.HSL), http://www.hse.gov.uk , (UK) BERGBAU BERUFSGENOSSENSCHAFT (IGF-BBG), www.igf-bbg.de , (DE) INSTITUT NATIONAL DE RECHERCHE ET DE SECURITE (INRS), www.inrs.fr , (FR) INSTITUTE OF OCCUPATIONAL MEDICINE (IOM), www.iom-world.org , (UK) INSTITUT FUR ENERGIE UND UMWELTTECHNIK EV - IUTA (IUTA), www.iuta.de , (DE) LUNDS UNIVERSITET (LU), www.lu.se , (SE) NANEUM LIMITED (NANEUM), WWW.NANEUM.COM , (UK) DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO (NFA), www.nrcwe.dk , (DK) STOCKHOLMS UNIVERSITET (SU), www.su.se , (SE) AALTO-KORKEAKOULUSAATIO (TKK), http://www.aaltoyliopisto.info/ , (FI) NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO (TNO), www.tno.nl , (NL) TSI GmbH (TSI), www.tsiinc.de , (DE) TTY-SAATIO (TUT), www.tut.fi , (FI) Itä-Suomen yliopisto (UKU), www.uef.fi , (FI) Karlsruher Institut fuer Technologie (UNIKARL), www.kit.edu , (DE)

NANODEVICE cont. •

Project Abstract: Due to their unique properties, engineered nanoparticles (ENP) are now used for a myriad of novel applications with great economic and technological importance. However, some of these properties, especially their surface reactivity, have raised health concerns, which have prompted scientists, regulators, and industry to seek consensus protocols for the safe production and use of the different forms of ENP. There is currently a shortage of field-worthy, cost-effective ways - especially in real time - for reliable assessment of exposure levels to ENP in workplace air. In addition to the problems with the size distribution, a major uncertainty in the safety assessment of airborne ENP arises from the lack of knowledge of their physical and chemical properties, and the levels of exposure. A special challenge of ENP monitoring is to separate ubiquitous background nanoparticles from different sources from the ENP. Here the main project goal is to develop innovative concepts and reliable methods for characterizing ENP in workplace air with novel, portable and easyto-use devices suitable for workplaces. Additional research objectives are (1) identification of relevant physicochemical properties and metrics of airborne ENP; establishment of reference materials; (2) exploring the association between physico-chemical and toxicological properties of ENP; (3) analyzing industrial processes as a source of ENP in workplace air; (4) developing methods for calibration and testing of the novel devices in real and simulated exposure situations; and (5) dissemination of the research results to promote the safe use of ENP through guidance, standards and education, implementing of safety objectives in ENP production and handling, and promotion of safety related collaborations through an international nanosafety platform.

NANODIARA • • •



Acronym: NANODIARA Project Title: Development of novel nanotechnology based diagnostic systems for Rheumatoid Arthritis and Osteoarthritis Participants: – – – – – – – – – – – – – – –

ANAMAR MEDICAL AB (AnaMar), www.anamar.com , (SE) Arrayon Biotechnology SA (Arrayon), www.arrayon.com , (CH) CHARITE - UNIVERSITAETSMEDIZIN BERLIN (Charité), www.charite.de , (DE) CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT (CSEM), www.csem.ch , (CH) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) MERCK CHIMIE SAS (Estapor), www.merck-chemicals.com , (FR) Europäische Akademie zur Erforschung von Folgen wissenschaftlich-technischer Entwicklungen (EUAK), www.ea-aw.de , (DE) MATSEARCH CONSULTING HOFMANN (MatSearch), http://www.matsearch.ch , (CH) MERCK SERONO SA (Merck Serono), http://www.merckserono.net/ , (CH) PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG (PMU), www.pmu.ac.at , (AT) STICHTING KATHOLIEKE UNIVERSITEIT (RUNMC), www.ru.nl , (NL) LUNDS UNIVERSITET (ULund), www.lu.se , (SE) UNIVERSITE DE FRIBOURG (UNI FRIBOURG), www.unifr.ch , (CH) UNIVERSITE DE GENEVE (UNIGE), www.unige.ch , (CH) TARTU ULIKOOL (UTartu), www.ut.ee , (EE)

Project Abstract: Based on the clinical unmet needs and recent research in biomarkers on Rheumatoid Arthritis (RA) and Osteoarthritis (OA) the main objective of the project is to develop a nanotechnology based novel diagnostic tool for easy and early detection of biomarkers in inflammatory diseases especially RA and OA by using modified superparamagnetic nanoparticles (SPION) for (A) bioassay (ex-vivo application) and (B) MRI (in-vivo detection). A new technology based on multiple functionalized single nanoparticles specifically entering/attaching to cells, to enzymes in serous fluids or organelles in living cells will be used to detect, separate and identify low abundance biomarkers. Newly identified biomarkers will be used to decorate SPION with binding moieties which are specific to the biomarker(s) and can be used diagnostically such as in contrast agents (MRI). A sensitive micro-immunoassay will be developed for special use of these particles in biochemical tests for arthritis. This project is driven by the high clinical need to identify early arthritis and then segment RA and OA patients into progressors/responders or non-progressors/-responders to various treatment options. Inflammatory disorders like RA inducing the destruction of cartilage in ≈ 1% of the population which is accompanied by significant pain, morbidity and mortality leads to reduced capacity to work. OA, a degenerative arthritis is the leading cause of disability among the elderly population. As there is no cure for RA and finally the replacement of e.g. the knee in OA, early diagnostic tools for the detection of the disease progression and the ability to evaluate the efficacy of therapeutic interventions are necessary u.a. for drug development. Existing diagnostic methods often do not permit an early definite diagnosis, so new nanoparticle based diagnostic techniques targeting to the detection of molecular events (based on MRI) with higher sensitivity/specificity will be developed to satisfy the urgent need.

NANODIRECT • • •

Acronym: NANODIRECT Project Title: Toolbox for Directed and Controlled Self-Assembly of nano-Colloids Participants: – – – – – –



FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (FORTH), www.forth.gr , (EL) FORSCHUNGSZENTRUM JUELICH GMBH (FZJ), www.fz-juelich.de , (DE) KATHOLIEKE UNIVERSITEIT LEUVEN (K.U.Leuven), www.kuleuven.be , (BE) UNIVERSITEIT TWENTE (UT), www.utwente.nl , (NL) UNIVERSITEIT UTRECHT (UU), www.uu.nl , (NL) DE VIGO (UVigo), www.uvigo.es , (ES)

Project Abstract: The proposed research aims at developing a toolbox for direct self-assembly of nano-colloids. Different methods to drive and modulate self-assembly in nano-colloids will be developed, compared and evaluated. The toolbox will consist of the following elements : (i) Building blocks: model particles with varying shape, functionality and directional interactions will be synthesized (ii) Directing Tools : Electric and Flow fields, surfaces and interfaces (iii) Test and development methods : Experimental platforms adapted at nano-particle research and simulations methods, capable of dealing with a range of length scales. The proposal specifically aims to study these methods which are prone to scale-up The research consortium consists of leading groups in the filed of colloid science and engineering and soft matter research. The seeds of this toolbox are clearly present in the consortium including methods for production of model (field responsive) nanoparticles, unique experimental tools, theoretical skills and mesoscale simulation methods. The key idea is to gradually evolve in the research to be able to deal with smaller length scales and a wider range of directing fields .

NANODNASEQUENCING • • •

Acronym: NANODNASEQUENCING Project Title: NanoTools for Ultra Fast DNA Sequencing Participants: – – – – – –



ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) THE HEBREW UNIVERSITY OF JERUSALEM. (HUJI), www.huji.ac.il , (IL) INSTITUT ZA FIZIKU (IPB), www.ipb.ac.rs , (RS) NUWAVE SYSTEM LTD (NW), www.nuwavesystem.com , (UK) THE PROVOST FELLOWS & SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (TCD), www.tcd.ie , (IE) UNIVERSITAET REGENSBURG (UR), http://www.uni-regensburg.de/ , (DE)

Project Abstract: The demand for a next-generation of technologies for DNA sequencing that will provide fast and affordable DNA decoding is pressing. Present bio-chemical schemes are time consuming and expensive, thus cheap and fast alternatives for DNA “reading” are of great need. This is now internationally recognized. For example, the US NIH recently awarded 40M$ in grants overpiloting projects to spur development of these innovative technologies. The goal of this project is to investigate a novel single-molecule DNA se-quencing nanotechnology protocol (gene sequencer) that has potential to sequence a molecule of genomic dimensions in hours without expensive and fault sensitive DNA copying steps and chemical reactions. The gene sequencer is based on the electrical characterization of individual nucleo-bases, while DNA passes through a nanopore with integrated nanotube side-electrodes. The research proposed here will provide a unique combina-tion of state of the art capabilities for cutting and usage of single wall carbon nanotubes as electrodes forming a lithographically fabricated “nanogap” with single-nanometer precision. In addition, the synergy of consortium resources for electrical characterization and leading theoretical skills for nanotransport will provide new solutions and information for an answer on the proof-of-principle question: is it possible to detect different types of DNA bases by their electrical properties? The overall objective of our collaborative research is to develop cheap and highspeed DNA sequencing technology. This will be achieved trough the following steps: 1. Fabrication of single wall carbon nanotube junction-gate for molecular recognition; 2. Exploring the interaction and conduction mechanisms between DNA and nanotube-electrode and DNA-nanopore; 3. Electrical characterization of the DNA nucleobases; 4. Development of model nano-electronic device for single-base DNA electrical characterization and decoding.

NANOEAR • • •

Acronym: NANOEAR Project Title: 3g-Nanotechnology based targeted drug delivery using the inner ear as a model target organ Participants: – – – – – – – – – – – – – – – – – – – – – – –

ABO AKADEMI (ABO), , (FI) AEQUOTECH SRL (AEQUOTECH), www.aequotech.com , (IT) CONSORZIO FERRARA RICERCHE (CFR), www.consorzioferrararicerche.it , (IT) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) HEMOTEQ AG (HTQ), www.hemoteq.de , (DE) USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (IEM), www.iem.cas.cz , (CZ) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (INSERM), www.inserm.fr , (FR) KUNGLIGA TEKNISKA HOEGSKOLAN (KTH), www.kth.se , (SE) MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH (MED-EL), www.medel.com , (AT) MEDIZINISCHE HOCHSCHULE HANNOVER (MHH), www.mh-hannover.de , (DE) MEDIZINISCHE UNIVERSITAET INNSBRUCK (MUI), www.i-med.ac.at , (AT) NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS (NKUA), www.elke.uoa.gr , (EL) NSGENE A/S (NSG), www.nsgene.com , (DK) RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN (RWTH-AACHEN), www.rwth-aachen.de , (DE) TAMPEREEN TEKNILLINEN YLIOPISTO (TUT), , (FI) UNIVERSITE D'ANGERS (UA), www.univ-angers.fr , (FR) HELSINGIN YLIOPISTO (UH.IB), http://www.helsinki.fi/university/ , (FI) RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG. (UHEI), www.uni-heidelberg.de , (DE) UNIVERSITAET ROSTOCK (UNI ROSTOCK), www.uni-rostock.de , (DE) UNIVERSITY OF SOUTHAMPTON (USOU), http://www.southampton.ac.uk , (UK) TAMPEREEN YLIOPISTO (UTA), www.uta.fi , (FI) UPPSALA UNIVERSITET (UU), www.uu.se , (SE) YORKSHIRE BIOSCIENCE LIMITED (YORKBIO), www.york-bio.com , (UK)

NANOEAR cont. •

Project Abstract: The goal of the NANOEAR consortium is to develop novel multifunctional nanoparticles (MFNPs), which are targetable, biodegradable, traceable in-vivo and equipped with controlled drug release. With over 44 million EU citizens with treatable hearing loss, and 40 000 profoundly deaf who can be benefit with MFNP-based novel cochlear implant, the inner ear is a unique target.Both a model for nervous system disorders and difficultto-access body sites; it is isolated, with neural and vascular targets, and is immunoprivileged. Measures of function and structure are quantitative and precise. Highly penetrating delivery vehicles will be created to carry and release drugs precisely to targeted tissue sites and selected cells. Nanoparticles, dendrimers, micelles and polymer-protein complexes will be designed for delivery of drugs/genes to selected targets of the inner ear. Four EU/FDA approved degradable biomaterials will be tested for targeting, coating, toxicity and payload carrier capacity. Commercially available liposomes, encapsulated by polyethylene glycol (PEG), impregnated with drugs, and modfied with targeting ligands and signaling molecules (gadolinium) will be assessed for benchmarking purposes. The fabricated MFNPs will be applicable to wide variety of drugs (e.g. conventional therapeutics, growth factors, proteins, nucleic acids, steroids). We will demonstrate greater selectivity, reduced side effects and greater efficacy than possible with current drug delivery, and provide treatments not currently possible. As a demonstration milestone this IP will produce a novel human cochlear implant promoting improved cochlear nerveimplant integration. In this demonstration the implant will include a MFNP drug reservoir providing continuous drug delivery and MFNP electrode coatings providing targets for nerve growth.

NANOFOL • • •

Acronym: NANOFOL Project Title: Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases Participants:



Project Abstract: NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.

– – – – – – – – – – – – –

Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda. (Alfama, Lda.), www.alfama.com.pt , (PT) ALMA CONSULTING GROUP SAS (ALMA), www.almacg.com , (FR) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (COCH), www.inserm.fr , (FR) EXBIO PRAHA AS (EXBIO), www.exbio.cz , (CZ) INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR - IBMC (IBMC), www.ibmc.up.pt , (PT) INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS (INERIS), www.ineris.fr , (FR) MEDIZINISCHE UNIVERSITAET WIEN (MUW), www.meduniwien.ac.at , (AT) SUAN FARMA S.A. (SUAN), http://www.suanfarma.sa , (ES) SYNOVO GMBH (SYNOVO), www.synovo.com , (DE) NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO (TNO), www.tno.nl , (NL) TECHNISCHE UNIVERSITAET GRAZ (TUG), www.tugraz.at , (AT) UNIVERSITATEA AUREL VLAICU DIN ARAD (UAV), www.uav.ro , (RO) E DO MINHO (UMINHO), www.uminho.pt , (PT)

NANOFORUMEULA • •

Acronym: NANOFORUMEULA Project Title: Nanoforum EU Latin America



Participants: – – – – – – –



COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER), www.fraunhofer.de , (DE) INSTITUTO POTOSINO DE INVESTIGACION CIENTIFICA Y TECNOLOGIA (IPICYT), http://www.ipicyt.edu.mx/ , (MX) MALSCH TECHNOVALUATION (MTV), www.malsch.demon.nl , (NL) SUPERINTENDENCIA DA ZONA FRANCA DE MANAUS (SUFRAMA), www.suframa.gov.br , (BR) AUTONOMA DE MADRID (UAM), http://www.uam.es , (ES) UNIVERSITEIT TWENTE (UT), www.utwente.nl , (NL)

Project Abstract: This SSA aims to foster lasting research relations between European research organisations and research organisations in Latin America specialising in nanotechnology. We do this by organising exchange visits for some twenty Latin American researchers to four European research organisations specialising in nanotechnology. Furthermore, we will organise two workshops and subsequent fact finding missions in Mexico and Brazil to enable European researchers and industrialists to identify opportunities for establishing working relations.

NANOHOUSE • • •

Acronym: NANOHOUSE Project Title: Life Cycle of Nanoparticle-based Products used in House Coating Participants:



Project Abstract: NanoHOUSE intends to create a holistic and prospective view on the Environmental Health and Safety (EHS) impacts of nanoproducts used in house building, namely paints and coatings. The latter are using relatively high amounts of Engineered NanoParticles (ENPs) such as nano-Ag and nano-TiO2 which will be investigated. A new Life Cycle Thinking (LCT) approach will be developed gathering two complementary aspects: Investigation of risks and opportunities during the product life cycle as well as Life Cycle Analysis (ISO 14040). LCT will collect information on EHS impacts throughout all life cycle stages of the nanoproducts, identifying the data gaps which will guide the research work. NanoHOUSE will generate reliable scientific information for the missing data and will develop appropriate methods to analyze the potential EHS impacts of nanoproducts. NanoHOUSE first task will be to quantify the actual sources of ENPs during the use and ageing of actual coatings (weathering, renovation, demolition and final disposal). The project will then characterize the environmental compartments significantly impacted by ENPs released from nanoproducts, measure ENPs concentrations and states in those compartments, and investigate their fate in order to increase the knowledge regarding exposure to ENPs with a view to reducing the risks. NanoHOUSE will study the environmental behaviour and the toxicological effects of actually released ENPs (“aged” ENPs) and compare them with pristine ENPs. Finally, NanoHOUSE will improve the solutions for end of life treatments regarding ENPs release in the environment. Main outcomes of the project will be a scientific risk evaluation of nanoproducts used in building, solutions to improve their competitive and sustainable development by decreasing their potential to release ENPs, and contributions to standard tests for their certification. The NanoHOUSE consortium involves 5 research/academic partners and 4 industrial manufacturers of which 1 SME.

– – – – – – – – –

Akzo Nobel Coatings S.A. (AKZO), , (FR) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) CONSORZIO VENEZIA RICERCHE (CVR), www.veneziaricerche.it , (IT) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) GFC Chimica s.r.l. (GFC), www.gfcchimica.com , (IT) KATHOLIEKE UNIVERSITEIT LEUVEN (KULeuven), www.kuleuven.be , (BE) Materis Paints Italia S.p.A. (MATERIS), www.materispaints.it , (IT) PPG Europe B.V. (PPG), www.ppg.com , (NL) UNIVERSITE JOSEPH FOURIER GRENOBLE 1 (UJF-LGIT), www.ujf-grenoble.fr , (FR)

NANOII • • •

Acronym: NANOII Project Title: Nanoscopically-guided induction and expansion of regulatory hematopoietic cells to treat autoimmune and inflammatory processes Participants: – – – – – – – – – –

– – – – –



CELLMADE SAS (CellMade), www.cellmade.com , (FR) CellTech Services Götz GmbH (CellTech Services), www.celltech-services.de , (DE) CHALMERS TEKNISKA HOEGSKOLA AB (CU), www.chalmers.se , (SE) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) Genome Identification Diagnostics GmbH (GID), aid-diagnostika.com , (DE) Idea Bio-Medical Ltd. (Idea Bio), , (IL) MILTENYI BIOTEC GMBH (Miltenyi), www.miltenyibiotec.com , (DE) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) UNIVERSITA DEGLI STUDI DI PERUGIA (PM), , (IT) MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER (SMC), www.sheba.co.il ; http://research.sheba.co.il , (IL) SCUOLA NORMALE SUPERIORE DI PISA (SNS), www.sns.it , (IT) UNIVERSITETET I BERGEN (UiB), www.uib.no , (NO) EBERHARD KARLS UNIVERSITAET TUEBINGEN (UKT), www.uni-tuebingen.de , (DE) UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT (UKW), www.klinik.uniwuerzburg.de , (DE) WEIZMANN INSTITUTE OF SCIENCE (Weizmann), www.weizmann.ac.il , (IL)

Project Abstract: We propose a multidisciplinary program, focusing on the development of novel approaches for directing the differentiation, proliferation and tissue-tropism of specific hematopoietic lineages, using micro- and nano-fabricated cell chips. We will use advanced nanofabricated surfaces functionalized with specific biomolecules, and microfluidics cell chips to specify and expend regulatory immune cells for treating diverse inflammatory and autoimmune disorders in an organ- and antigen-specific manner. The proposed cell-chip will create ex-vivo microenvironments mimicking in-vivo cell-cell interactions and molecular signals involved in differentiation and proliferation of hematopoietic cells. Cell chip development and optimization will be supported by high throughput microscopy to select for optimal conditions. “Educated” cells will be employed for in vivo experiments in mice and the methodology will be further adapted for human cell populations, and applied for clinical diagnosis and therapy as well as the developments of clinically-relevant devices. Regulatory T-cells are extremely promising cells for treatment of inflammatory and auto-immune disease, as well as for tolerance induction in organ transplantation. To be effective they must be produced conveniently, at large numbers with an optimally tuned phenotype. The methodology is suggested to overcome current obstacles in obtaining therapeutically significant numbers of T cells. We propose to apply the suggested methodology for treating different inflammatory or autoimmune diseases including type-1 diabetes using targeted immunotherapeutic approaches. Developing new methods for producing large numbers of finely-tuned and tissue-targeted regulatory cells will make this approach clinically viable. This novel methodology can be extended to directing differentiation of other specific T-cell and hematopoietic lineages, with possible applications for targeting other autoimmune diseases and treating tumors or graft rejection.

NANOIMPACTNET • • •

Acronym: NANOIMPACTNET Project Title: European Network on the Health and Environmental Impact of Nanomaterials Participants: – – – – – – – – – – – – – – – – – – – – – – – –

COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) HOSPICES CANTONAUX CHUV (CHUV), www.chuv.ch , (CH) NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS" (Demokritos), www.demokritos.gr , (EL) DEUTSCHE GESETZLICHE UNFALLVERSICHERUNG (DGUV-BGIA), , (DE) DUBLIN INSTITUTE OF TECHNOLOGY DIT (DIT), , (IE) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (Empa), www.empa.ch , (CH) TYOETERVEYSLAITOS. (FIOH), www.ttl.fi , (FI) HEALTH AND SAFETY EXECUTIVE (HSE.HSL), http://www.hse.gov.uk , (UK) INSTITUTE OF OCCUPATIONAL MEDICINE (IOM), www.iom-world.org , (UK) INSTITUT UNIVERSITAIRE ROMAND DE SANTE AU TRAVAIL (IST), www-.i-s-t.ch , (CH) INSTITUT FUR ENERGIE UND UMWELTTECHNIK EV - IUTA (IUTA), www.iuta.de , (DE) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) NORSK INSTITUTT FOR LUFTFORSKNING (NILU), www.nilu.no , (NO) EDINBURGH NAPIER UNIVERSITY (NU), www.napier.ac.uk , (UK) STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK (RIKILT - DLO), , (NL) RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (RIVM), www.rivm.nl , (NL) SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE (SMU), www.szu.sk, www.upkm.sk , (SK) ST MARY'S UNIVERSITY COLLEGE TWICKENHAM (SMUC), www.smuc.ac.uk , (UK) UNIVERSITAET BERN (UBERN), http://www.unibe.ch , (CH) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (UCD), www.ucd.ie , (IE) Københavns Universitet (UCPH), www.ku.dk , (DK) UNIVERSITY OF SURREY (UNIS), www.surrey.ac.uk , (UK) UNIVERSITY OF PLYMOUTH (UoP), , (UK)

NANOIMPACTNET cont. •

Project Abstract: Recent technological advances allow the targeted production of objects and materials in the nanoscale (smaller than 100 nm). Nanomaterials have chemical, physical and bioactive characteristics, which are different from those of larger entities of the same materials. Nanoparticles can pass through body barriers. This is interesting for medical applications, but it raises concerns about their health and environmental impact. The objective of the NanoImpactNet is to create a scientific basis to ensure the safe and responsible development of engineered nanoparticles and nanotechnology-based materials and products, and to support the definition of regulatory measures and implementation of legislation in Europe. It includes a strong two-way communication to ensure efficient dissemination of information to stakeholders and the European Commission, while at the same time obtaining input from the stakeholders about their needs and concerns. The work plan shows six work packages (WPs: Human hazards and exposures, Hazards and fate of nanomaterials in the environment, Impact assessment, Communication, Integration and nomenclature, and Coordination and management). The work plan will be implemented over four years. Discussions about strategies and methodologies will be initiated through well-prepared workshops covering the WP topics. External researchers and stakeholders will be invited to participate. After these workshops, the researchers will collaborate to produce thorough reports and sets of guidelines reflecting the consensus reached. All of the leading European research groups with activities in nanosafety, nanorisk assessment, and nanotoxicology are represented in NanoImpactNet. All exposure routes, major disease classes and impact assessment approaches are represented within the network. It will coordinate activities within Europe. It will help implement the EU Actionplan for Nanotechnology and support a responsible and safe development of nanotechnologies in Europe.

NANOIMPRINT • • •

Acronym: NANOIMPRINT Project Title: NANOIMPRINTING TECHNOLOGIES FOR SELECTIVE RECOGNITION AND SEPARATION Participants:



Project Abstract: It is widely accepted that molecularly imprinted polymers will be one of the most important technological and scientific challenges in the fields of biotechnology, separation, purification, analytical science, catalysis, biomdical and environmental applications. Particular advantages to be realized by MIPs are the low preparation cost and the potential utility in situations where no recognizing biomolecule is available. The present "NANOIMPRINT" proposal addresses the following S&T objectives: 1. Novel synthesis routes for the economically feasible production of MIPs, taking into account limitations of the current synthetic approaches, and the rational design of improved imprinting materials. 2. MIPs for selective recognition and separation of biological molecules. Development of MIPs for selective recognition and separation of biological materials, utilizing reagents and polymerization techniques for delicate molecules such as oligosaccharides, peptides and for large structures such as proteins. 3. Carbohydrate imprinted polymers as enhancers of bioactive compounds in microbial cultures. 4. MIPs as artificial receptors. Production of artificial receptors with high substrate selectivity and specificity for analytical science applications (immunoassays, chromatography, capillary electrophoresis and solid phase extraction). 5. Understanding the mechanisms controlling the molecular structure. The present consortium combines the expertise of academic and research scientists (i.e., three university departments, four research institutes) in complementary scientific and technical areas with the business focus of one SME aiming to promote collaborative research and technology developments in biotechnology, environmental control, bioseparation, enzyme technology and biochemical analysis. A second SME, Eurobiotec S.A., which does not legally exist at the moment, will join the consortium at a later stage, after its registration (presumably until month 7).

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ARISTOTELIO PANEPISTIMIO THESSALONIKIS (A.U.TH), www.auth.gr , (EL) CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS (CERTH), WWW.CERTH.GR , (EL) EUROBIOTEC BRUSSELS SA (EUROBIOTEC), www.eurobiotec.be , (BE) BUNDESFORSCHUNGSANSTALT FUER LANDWIRTSCHAFT (FAL), www.fal.de , (DE) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER), www.fraunhofer.de , (DE) GENIALAB BIOTECHNOLOGIE - PRODUKTE UND DIENSTLEISTUNGEN GMBH (GENIALAB), www.genialab.com , (DE) LUNDS UNIVERSITET (LPAB), www.lu.se , (SE) MEURICE RECHERCHE ET DEVELOPPEMENT ASBL (MR&D), www.meurice.heldb.be , (BE) THE UNIVERSITY OF WESTMINSTER (UOW), , (UK)

NANOINTERACT • • •

Acronym: NANOINTERACT Project Title: Development of a platform and toolkit for understanding interactions between nanoparticles and the living world Participants: – – – – – – – – – – – –

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DSM INNOVATION CENTER BV (DSM), www.dsm.com , (NL) GLANTREO LIMITED (GLAN), www.glantreo.com , (IE) INTEL PERFORMANCE LEARNING SOLUTIONS LIMITED (INTEL), www.itic.intel.com , (IE) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMU), www.uni-muenchen.de , (DE) L'OREAL SA (L'ORéAL), www.loreal.com , (FR) LUNDS UNIVERSITET (LU), www.lu.se , (SE) MEDTRONIC BAKKEN RESEARCH CENTER BV (MED), www.medtronic.com , (NL) INSTYTUT MEDYCYNY PRACY NOFERA (NIOM), www.imp.lodz.pl , (PL) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (NUID/UCD), www.ucd.ie , (IE) RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (RIVM), www.rivm.nl , (NL) WILLIAM MARSH RICE UNIVERSITY (RU), www.rice.edu , (US) THE PROVOST FELLOWS & SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (TCD), www.tcd.ie , (IE) UNIVERSITEIT GENT (UGENT), http://www.ugent.be , (BE) UMICORE NV* (UMICORE), www.umicore.com , (BE) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD (UOXF.DN), www.ox.ac.uk , (UK) UNIVERSITE PARIS-SUD XI (UPS), www.u-psud.fr , (FR) UNIVERSITY OF ULSTER (UU), www.ulster.ac.uk , (UK) WEIZMANN INSTITUTE OF SCIENCE (WEIZMANN), www.weizmann.ac.il , (IL)

Project Abstract: We combine state-of-the-art techniques, metholdolgies, skills and instrumentation from several scientific arenas to create discipline-independent platforms to address key questions in nanotoxicology. Thus, we identify the routes via which nanoparticles enter and accumulate in living organisms, and connect this to representative cell-nanoparticle systems. Then using the most advanced methods of chemical, physical, biological and toxciological sciences we connect nanoparticle properties (in physiological conditions) to the mechanisms via which they interact with, and disrupt, cellular processes. We establish means and protocols via which every step of the program will be controlled, eliminating the factors that currently cause irreproducibilities. We emphasize novel unbiased assessments of intra- and inter-cellular processes after exposure to nanoparticles, enabling us to explore known, and unknown, processes. Key companies, large and small from several end-user groups, that are currently facing the challenge of applying nanotechnology in their products are built into the program in a substantial manner, and other key stake-holders are also incorporated into the overall consortium via the Advisary Board. This will ensure maximum uptake of the knowledge generated by NanoInteract, and enable development of Standards for nanoparticle risk assessment.

NANOLOGUE • •

Acronym: NANOLOGUE Project Title: Nanologue: Facilitating the dialogue between research, business and the civil society to improve the quality of life, create wealth and reduce impacts to society



Participants: – – – –



EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) THE FORUM FOR THE FUTURE (FFF), www.forumforthefuture.org.uk , (UK) TRIPLE INNOVA (TI), www.triple-innova.com , (DE) WUPPERTAL INSTITUT FUR KLIMA, UMWELT, ENERGIE GMBH. (WI), www.wupperinst.org , (DE)

Project Abstract: Nanologue's overarching goal s to facilitate dialogue between researcher, business and the civil society about the potential of nanoscience and nanotechnology (NT) applications to improve the quality of life, create wealth, and to assess the technologies' potential societal impacts. Based on an intensive dialogue and dissemination process, Nanologue facilitates the translation of civil society's ethical, legal and social requirements on NT research into a real competitive advantage for the European industry. By drawing from international projects, studies and expertise, the benefits and potential ethical, legal and social impacts of NT applications likely to be rolled out by 2010 will be identified. Assisted by an expert dialogue board and a series of stakeholder interviews and workshops, preliminary findings will be further substantiated and validated. Foresight studies will demonstrate 3 plausible and realistic futures of NT. Results will be disseminated with help of a comprehensive communication strategy, targeting researchers, decision makers in business and politics, ediucational institutions, media, and the civil society. The cooperation with an existing NT web-platform, media-workshops, publicity materials and conference attendances will support a broad outreach and further substantiate dialogue. Public research funds, researchers and business will be supported with an interactive tool to quickly consider the ethical, legal and social aspects of NT projects already in the proposal and development phase.'

NANOMAN • • •

Acronym: NANOMAN Project Title: Control, manipulation and manufacture on the 1-10nm scale using localised forces and excitations Participants: – – – – – – – –



BILKENT ÜNIVERSITESI (BILKENT), www.bilkent.edu.tr , (TR) CHALMERS TEKNISKA HOEGSKOLA AB (CHALMERS), www.chalmers.se , (SE) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS - ORSAY), www.cnrs.fr , (FR) IBM RESEARCH GMBH (IBM ZRL), www.zurich.ibm.com , (CH) KING'S COLLEGE LONDON (KCL), www.kcl.ac.uk , (UK) UNIVERSITY COLLEGE LONDON (UCL), http://www.ucl.ac.uk , (UK) THE UNIVERSITY OF NOTTINGHAM (UNOTT), www.nottingham.ac.uk , (UK) UNIVERSITAET OSNABRUECK (UOS), www.uni-osnabrueck.de , (DE)

Project Abstract: We will develop new technologies for handling and control of single molecules and nanostructures on the sub 10nm scale. These techniques will be based on atomic force microscopy (AFM) so that manipulation protocols may be applied on insulating surfaces, thus overcoming one of the major limitations of current state-of-the-art techniques. The fundamental processes which control AFM manipulation in nanoscale manufacture will be determined through a collaborative theoretical and experimental exploration of the frontiers of knowledge. The new techniques will enable long term innovation in the areas of molecular nanostructures, controlled self assembly and nanomachines and we will demonstrate several novel applications which form key milestones. The consortium is formed from internationally leading groups in the areas of molecular and nanoscale fabrication and the project directly addresses section 3.4.1.4, of the Priority 3 NMP Workprogramme, 'Development of handling and control devices and instruments'. The project objectives will be achieved through effective management and will be disseminated widely, in particular through an SMEs forum. This project will safeguard the leading status of researchers in the European Research Area and underpin the emergence of key nanotechnologies in Europe. The consortium will also be highly proactive in of wider societal objectives including the promotion of gender equality and the public understanding of science.'

NANOMESH • • •

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Acronym: NANOMESH Project Title: Nanomesh - Boron Nitride Nanomesh as a Scaffold for Nanocatalysts, Nanomagnets and Functional Surfaces Participants: – – – – – – – –

HITACHI EUROPE LIMITED (HEL), www.hitachi-eu.com/index.jsp , (UK) JUSTUS-LIEBIG-UNIVERSITAET GIESSEN (JLU), www.uni-giessen.de , (DE) TECHNISCHE UNIVERSITAET WIEN (TUW), www.tuwien.ac.at , (AT) UNIVERSITAET AUGSBURG. (UA), www.uni-augsburg.de , (DE) UNIVERSITEIT LEIDEN (ULEI), http://www.leidenuniv.nl , (NL) THE UNIVERSITY OF NOTTINGHAM (UNOTT), www.nottingham.ac.uk , (UK) UNIVERSITAET DES SAARLANDES (USAAR), www.uni-saarland.de , (DE) UNIVERSITAET ZUERICH (UZH), http://www.unizh.ch , (CH)

Project Abstract: The NanoMesh project is based on the recent discovery by one of the proposing groups of a spectacular nanostructure of hexagonal boron nitride that self-assembles on a rhodium metal surface [M. Corso et al., Science 303, 217 (2004)]. It is a supported, mesh-like structure consisting of two atomic layers with a periodicity of 3.2 nm and holes of about 2 nm. The relevance of the project to the thematic area 3.4.1.1 is twofold. With roughly 400 boron and nitrogen atoms in the mesh unit cell, the self-assembly process is truly remarkable, and it is accessible to live observation by surface science techniques, including scanning tunneling microscopy under process conditions. By elucidating the self-assembly mechanism in this highly non-trivial case, the project is very likely to provide new and general insight in this efficient and cheap type of nanostructure formation. The second key point of relevance lies in the nature and the stability of the boron nitride nanomesh. It is inert and stable up to 1000 K, and it thus lends itself perfectly as a template or scaffold material for forming secondary nanostructures. Metal deposition on the nanomesh is expected to produce highly monodisperse metallic nanoclusters that represent prime candidates for catalysts with high activity and selectivity, or for nanostructured magnets with superior magnetic or spintronic properties. The edges around the pores of the mesh permit the stable covalent attachment of organic or even biological molecules of desired functionality, thus leading to well structured functional surfaces. The attachment of large molecules should lead to higher hierarchies of self-assembling supramolecular structures that should be very interesting for biotechnology applications. In full expectation of these applications, the project also addresses the production issues related to precursor molecules and substrates.

NANOMMUNE • • •



Acronym: NANOMMUNE Project Title: Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system Participants: – – – – – – – – – –

EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) INSTITUTE OF OCCUPATIONAL MEDICINE (IOM), www.iom-world.org , (UK) KAROLINSKA INSTITUTET (KI), www.ki.se , (SE) KUNGLIGA TEKNISKA HOEGSKOLAN (KTH), www.kth.se , (SE) North Carolina State University (NCS), ncsu.edu , (US) NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH), http://www.cdc.gov/niosh/ , (US) UNIVERSITAET ZU KOELN (UCO), www.uni-koeln.de , (DE) UNIVERSITY OF PITTSBURGH (UP), www.pitt.edu , (US) TURUN YLIOPISTO (UT), , (FI) UPPSALA UNIVERSITET (UU), www.uu.se , (SE)

Project Abstract: Engineered nanomaterials (ENs) present tremendous opportunities for industrial growth and development, and hold great promise for the enrichment of the lives of citizens, in medicine, electronics, and numerous other areas. However, there are considerable gaps in our knowledge concerning the potential hazardous effects of ENs on human health and the environment. Our EU-US partnership is committed to filling these knowledge gaps through a comprehensive assessment of ENs, with particular focus on effects on the immune system. The immune system is designed to respond to pathogens and foreign particles, and a core concept underpinning the current project is that the recognition versus non-recognition of ENs by immunecompetent cells will determine the distribution as well as the toxicological potential of these materials. Our multidisciplinary consortium will focus on the procurement, synthesis and detailed physico-chemical characterization of representative categories of ENs, and the monitoring of potential hazardous effects using an array of in vitro and in vivo systems, as well as transcriptomic and oxidative lipidomic testing to determine specific nanotoxic profiles (signatures) of these materials. The final and integrative component of our research project is risk assessment of potential adverse effects of ENs on human health, and the dissemination of our findings. Through our comprehensive approach, which combines analytical procedures from many different disciplines and leading experts from several national institutes devoted to occupational and environmental safety, we aim to establish a panel of read-out systems for the prediction of the toxic potential of existing and emerging ENs, thus enabling a continuous and sustainable growth of the nanotechnologies. Overall, the results generated through this international program will contribute to the understanding and mitigation of possible adverse effects of nanomaterials.

NANO-MUBIOP • • •

Acronym: NANO-MUBIOP Project Title: Enhanced sensitivity Nanotechnology-based Multiplexed Bioassay Platform for diagnostic applications Participants:



Project Abstract: Currently, there is strong interest in the development of new bioassay techniques for gene identification, gene mapping, DNA sequencing and medical diagnostics. There are three main families of methods: Polymerase Chain Reaction, Enzyme-Linked Immunosorbent Assay and nano-particles agglutination techniques. All these methods suffer from several disadvantages as they are time-consuming and expensive, they are not quantitative and exclude multiplexing, i.e. the detection of different genotypes simultaneously. The need of a new multiplexing and quantitative bioassay technique is evident. The aim of this project is to develop a high sensitivity multiplexed platform based on a bio-non bio nanostructure able to enhance diagnostic capabilities by exploiting the dimensional shift from bio-systems to nanometric particles, thus overcoming many of the limitations of the existing methods. This method could be adapted to the detection of many kinds of bio-systems, but the project will focus on Human Papilloma Virus (HPV) responsible for cancer. The project idea is based on the development of nanoparticles functionalised with probes complementary to HPV DNA conservative region and an array of specific bio-probes for the different HPV genotypes deposited on a solid substrate. The nanoparticles will bind to the bio-system and then they will diffuse through the suspension docking to the area of the array where the probe specific for that genotype is coated. An array of nanoparticles will be created and the concentration of each HPV genotype can be quantified by estimating the number of particles bounded to each specific area. Considering the global worldwide market of the immune and genetic tests (20 Billion €) the potential economic impact can be up to 100 M€. Private/public national or local health service providers will get benefits from NANO-MUBIOP, the single test cost being about 4 € for the service provider. Last but not least, the costs will be reduced for the patients.

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HOSPITEX DIAGNOSTICS SRL (HOSPITEX), www.hospitex.it , (IT) INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), www.inra.fr , (FR) LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI (LENS), www.lens.unifi.it , (IT) DUBLIN CITY UNIVERSITY (NSCR), www.dcu.ie , (IE) INSTITUT PASTEUR (PI), http://www.pasteur.fr , (FR) UNIVERSITA DEGLI STUDI DI FIRENZE (UNIFI), http://www.unifi.it , (IT) URATIM GYARTO KORLATOLT FELELOSEGU TARSASAG (Uratim), www.uratim.com , (HU) XENNIA TECHNOLOGY LIMITED (Xennia), www.xennia.com , (UK)

NANOPV • • •

Acronym: NANOPV Project Title: Nanomaterials and nanotechnology for advanced photovoltaics Participants:



Project Abstract: The NanoPV project aims at making a breakthrough step-change in photovoltaics by the removal of a set of bottlenecks which have been identified to block the application of nanostructures for high-efficiency, low-cost solar cells. The bottlenecks arise from the present lack of up-scalable processes that can meet the needs for nanomaterials in PV applications, and the lack of relevant equipment and industrial lines. In order to remove these bottlenecks, the main objectives of NanoPV are: 1) To develop technologies that can increase the efficiency and reduce the processing cost of existing silicon solar cell technologies using nano-scale effects provided by nanomaterials to above 20% for wafer based and above 15 % for thin film silicon based solar cells at a processing cost for modules well below 1 €/watt. 2) To design and to fabricate low cost solar cells entirely from nanomaterials by using nanostructures. An efficiency of above 10 % at processing costs well below 1 €/watt is targeted with potential of further significant improvements in the future. 3) To develop up-scalable cost effective processes and equipment in order to implement both enhanced standard solar cells and solar cell based on nanomaterials as well as related modules to existing pilot and industrial lines. 4) To create new market opportunities for the industrial partners. Nanotechnology will be applied for both already existing conventional Si solar cells (wafer and thin-film based) and for advanced solar cells entirely based on nanostructures. The main scientific efforts will be on understanding and exploitation of such nanomaterials as i) 0D quantum dots, nanocrystals and nanoparticles, ii) 1D nanowires and nanorods, and iii) 2D nanomaterials such as ultrathin layers. A large number of specialised technologies will be applied in the project. Therefore, in order to ensure successful completion, a comparatively large consortium of 9 complementary research partners and 3 industries has been assembled.

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CENTRAL LABORATORY OF SOLAR ENERGY& NEW ENERGY SOURCES OF THE BULGARIAN ACADEMY OF SCIENCES (CLS), http://www.senes.bas.bg/ , (BG) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) STICHTING ENERGIEONDERZOEK CENTRUM NEDERLAND (ECN), www.ecn.nl , (NL) HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH (HZB), www.helmholtz-berlin.de , (DE) To be confirmed (IMPT), , (UK) INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V (IPHT), www.ipht-jena.de , (DE) Oxford Instruments Plasma Technology Ltd (OIPT), , (UK) INSTITUT RUDER BOSKOVIC (RBI), www.irb.hr , (HR) STIFTELSEN SINTEF (SINT), www.sintef.no , (NO) To be confirmed (SSP), , (DE) UNIVERSITAT DE VALENCIA (UVEG), www.uv.es , (ES) TECHNISCHE UNIVERSITAET MUENCHEN (WSI), www.tu-muenchen.de , (DE)

NANOQUANTA • • •

Acronym: NANOQUANTA Project Title: Nanoscale Quantum Simulations for Nanostructures and Advanced Materials Participants:



Project Abstract: The ability to invent new functionalities for nanoscale systems and advanced materials, such as quantum dots, biomolecules, and carbon nanowires, and of designing new devices for specific applications depend heavily on our understanding of the excitation under irradiation by light, electron beams or modern photon sources (synchrotrons, ultra-fast lasers), and also of the reaction of the environment to the electronic response. This NANOQUANTA Network of Excellence sets out our plan to integrate and develop the research capabilities of ten European teams in the field of the fundamental science of nanoscale systems and advanced materials, exploiting the now powerful combination of quantum-mechanical theory and computer simulation to make contact with nanoscience experimental studies and also directly with technologically relevant electronic, dynamic and optical processes. An ambitious reach-out programme is at the heart of our Network, first through dissemination of ideas, theories, algorithms and computer programs to the wider European theory community through publication, workshops, conferences and training (both Internet-based and hands- on), and also through two-way contact with experimental and applied research groups in European universities, research institutions and companies. Our vision can be summarised in the concept of an ongoing "European Theoretical Spectroscopy Facility (ETSF)" for nanoscale systems and advanced materials, with strong links with a wide range of research groups, which we shall develop from the collaborative research activity and reach-out initiatives to be established under the NANOQUANTA NoE.

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MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (BERLIN-FHI), www.mpg.de , (DE) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) ECOLE POLYTECHNIQUE (ECOLE POLYTECHNIQUE), , (FR) FRIEDRICH-SCHILLER-UNIVERSITAET JENA (FSU), www.uni-jena.de , (DE) FREIE UNIVERSITAET BERLIN (FUB), www.fu-berlin.de , (DE) UNIVERSITE CATHOLIQUE DE LOUVAIN (UCL), www.uclouvain.be , (BE) LUNDS UNIVERSITET (ULUND), www.lu.se , (SE) UNIVERSITA DEGLI STUDI DI MILANO (UNIMI), www.unimi.it , (IT) DEL PAIS VASCO (UPV/EHU), www.ehu.es , (ES) UNIVERSITY OF YORK (YORK), http://www.york.ac.uk , (UK)

NANORAC • • •

Acronym: NANORAC Project Title: Nano robotic for assembly characterisation Participants:



Project Abstract: The objectives of this project are to develop efficient instrumentation for measurement, analysis and manufacture at the nano-scale. We propose a robotic system which would allow an untrained operator to interact with nano-scale objects for characterization, sorting and assembly tasks. This approach makes it necessary to study and resolve different problems in order to create a robust robotic system capable of the desired functionalities. The scientific approach developed in this proposal is applicable to all nano-scale objects but as a concrete example, will concentrate on the carbon nanotubes.

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CARL VON OSSIETZKY UNIVERSITAET OLDENBURG (AMIR), , (DE) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 (LRP), www.upmc.fr , (FR) NASCATEC GMBH* (NASCATEC GMBH), www.nascatec.com , (DE) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UCAM-DENG), www.cam.ac.uk , (UK)

First of all, precise manipulation calls for a clear understanding of the physical specificities of the nanoscale. Secondly, based on this knowledge, adapted manipulation tools and grippers can be designed. Then, given precise pick-up and release tasks, manipulation strategies and corresponding control schemes must be established. The second important point is to provide the human operator an optimal mean to control the operation. The difficulty is that the classical optical methods dont work because of the smaller than lights wavelength size of the targeted objects. Techniques such as SEM (Scanning electron Microscopy) exist but the resulting 2D images do not provide sufficient position information for a precise manipulation. A 3D virtual reality reconstruction of the manipulation is a good solution to provide the user a complete set of information on the operation. Moreover, a haptic interface will furnish a most intuitive interaction between the operator and the system. The activities forecast by the project proposal, will generate fundamental improvements for any future possible applications and, in the long term, will stimulate either the industrial production of the nano based products and their applications and the employment of the developed knowledge in further research projects.

NANORETOX • • •



Acronym: NANORETOX Project Title: THE REACTIVITY AND TOXICITY OF ENGINEERED NANOPARTICLES: RISKS TO THE ENVIRONMENT AND HUMAN HEALTH Participants: – – – – – – – – – – – –

AHAVA DEAD SEA LABORATORIES LTD (DSL), , (IL) INTRINSIQ MATERIALES LIMITED (IML), www.intrinsiqmaterials.com , (UK) IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (IMPERIAL), www.imperial.ac.uk , (UK) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) KING'S COLLEGE LONDON (KCL), www.kcl.ac.uk , (UK) NATURAL HISTORY MUSEUM (NHM), , (UK) ROSKILDE UNIVERSITET (RU), www.ruc.dk , (DK) UNIVERSITE CATHOLIQUE DE L OUEST ASSOCIATION SAINT YVES (UCO), www.uco.fr , (FR) UNIVERSITA DI PISA (UNIPI), www.unipi.it , (IT) UNIVERSITE DE NICE - SOPHIA ANTIPOLIS (UNS), , (FR) DEL PAIS VASCO (UPV-EHU), www.ehu.es , (ES) DEPARTMENT OF THE INTERIOR USA (USGS), , (US)

Project Abstract: NanoReTox will identify the potential risks to the environment and human health posed by free engineered (i.e. manmade) nanomaterial by comprehensively addressing five key questions: (1) How does the environment into which nanoparticles are released affect their physicochemical properties and their bioreactivity? (2) How does this impact on their ability to interact with and/or penetrate mammalian and aquatic cells and organisms (bioavailability) and will bioavailability result in toxicity? (3) Is there a pattern of cellular reactivity and/or toxicity related to physicochemical properties, i.e. a hierarchy of activity? (4) What combination of conditions discovered in (1-3) above are most likely to pose a risk to human health and the environment? (5) How can this information be incorporated in a risk assessment model? We have assembled a team of experts from across the EU and the US whose combined expertise can address these questions in depth, and therefore comprehensively cover the scope of research topic NMP-2007-1.3-2 – Risk assessment of engineered nanoparticles on health and the environment.

NANOROADMAP • • •



Acronym: NANOROADMAP Project Title: Technological roadmaps till 2014 in nanoscience and nanotechnologies in materials, health and medical systems, energy fields Participants: – – – – – – – –

ASSOCIAZIONE ITALIANA PER LA RICERCA INDUSTRIALE - AIRI (AIRI), www.airi.it , (IT) INSTITUTE OF NANOTECHNOLOGY (ION), www.nano.org.uk , (UK) MATIMOP, ISRAELI INDUSTRY CENTER FOR RESEARCH & DEVELOPMENT (MATIMOP), www.matimop.org.il , (IL) TECHNOLOGICKE CENTRUM AKADEMIE VED CESKE REPUBLIKY (TECHCENT), www.tc.cz , (CZ) VDI/VDE INNOVATION + TECHNIK GMBH (VDI/VDE-IT), www.vdivde-it.de , (DE) VALTION TEKNILLINEN TUTKIMUSKESKUS (VTT), www.vtt.fi , (FI) WILLEMS & VAN DEN WILDENBERG BV (W&W), www.wnw.eu.com , (NL) YOLE DEVELOPPEMENT SARL. (YOLE DèVELOPPMENT), www.yole.fr , (FR)

Project Abstract: The primary objective of NANOROADMAP (NNRM) is to produce roadmaps for the application of nanotechnology in three industrial fields (materials, health and medical systems and energy) that will cover the next ten years. The project, in complete agreement with the priorities set for FP6, will proceed along a path that will be time and cost effective. In the first 8 months NNRM will collect all the documentation relevant for the preparation of a road map that has been published on nanotechnology in the last few years to distils the general scenario to start with. From this scenario the Consortium will select within each of the three above said fields the most important (2- 4) themes "golden" to focus on, together with 1-2 more themes, also of high interest, but of lesser importance "silver". The "golden" themes will be investigated in great detail with extensive face-to-face communication through working groups, Delphi panels, conferences and (web-enabled) fora. For the "silver" themes, on the contrary, a fully web-integrated roadmapping methodology and tool-set will be used. This methodology, though somehow less thorough, is quite more cost-effective and therefore by combining the two approaches NNRM will deliver a road map that cover not only the main themes, but also those of second level, at a reduced cost. In total 12 applications will be investigated. The assessment will focus on drivers of change, scientific and technical challenges and barriers, market demands and funding needs, R&D strategies, infrastructures relevant for research and application of nanotechnologies, social and ethical issues. Dissemination, discussion and feedback of the results is a crucial part of the project. This will be done capillary by all the partners. With specific web sites, distribution of documents, articles and release in the press, direct contacts and, in particular, with the organisation of 2 International Symposia and 8 National Conference.

NANORUCER • • •

Acronym: NANORUCER Project Title: Mapping the NANOtechnology innovation system of RUssia for preparing future Cooperations between the EU and Russia Participants: – –



FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (Fraunhofer), www.fraunhofer.de , (DE) Establishment of the Russian Academy of Sciences the Institute for the Study of Science of Russian Academy of Sciences (ISS RAS), htpp://www.issras.ru , (RU)

Project Abstract: The EU is interested in obtaining a survey of main Russian research infrastructures active in nanotechnology and nano-structured materials as a basis for initiating future cooperations between the EU and Russia. In the NANORUCER activity two leading organization from the EU and Russia in the fields of innovation research and nantoechnology join forces to deliver this aim. Based on a performance analysis using bibliometrics and patent statistics and a careful in depth mapping of nanotechnology and nano-strucutured materials research activities in Russia, a strengths and weaknesses analysis of the Russian nanotechnology innovation system will be made. A systematic comparison with respective EU R&D activities in nanotechnology and nano-structured materials will allow identifying opportunities for future cooperations between the EU and Russia. These will be specified by thematic fields in order to detect areas of common interests with most benefits for cooperating partners. Involving Russian and EU stakeholders during workshops, recommendations for supporting such cooperations between the EU and Russia will be developed, and concrete actions proposed. A particular strength of the proposed support action is that it can build on a broad experience of both participants in analysing nanotechnology innovation systems. In previous projects the Russian partner has already developed databases of R&D organizations providing research on nanoscale and its staffs provided the expertise for the National Program of Infrastructure Development for Nanotechnology. In addition the participants will mobilize the in depth knowledge of their mother organizations, the Fraunhofer Society and in particular the Fraunhofer Alliance Nanotechnology, and the Russian Academy of Sciences, in nantotechnology R&D.

NANOS4 • • •

Acronym: NANOS4 Project Title: Nano-structured solid-state gas sensors with superior performances Participants: – – – – – – – – – –



APPARATEBAU GAUTING GMBH. (AOA), www.aoa-gauting.de , (DE) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) EADS DEUTSCHLAND GMBH (EADS), www.eads.net , (DE) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FHG-IPM), www.fraunhofer.de , (DE) CONSIGLIO NAZIONALE DELLE RICERCHE (IMM-CNR), www.cnr.it , (IT) INSTITUT POLYTECHNIQUE DE GRENOBLE (INPG), http://lepmi.grenoble-inp.fr , (FR) LABORATORI INTEGRATI STUDIO ALFA SRL (LISA), www.studioalfa.it , (IT) SACMI COOPERATIVA MECCANICI IMOLA SCARL (SACMI), www.sacmi.com , (IT) UNIVERSITAT DE BARCELONA (UB), http://www.ub.es , (ES) VAISALA OYJ (VAI), www.vaisala.com , (FI)

Project Abstract: The main objective of NANOS4 is a breakthrough in advanced micro- and nano-technologies for developing innovative metal-oxide gas sensing systems based on mesoscopic sensors. The sensors will be fabricated by nanoengineering techniques like vapour phase transport process crystal growth and other advanced techniques of preparation. Optical, ion and electron beam nanolithography will be a tool for selective removal of materials. The materials will be deposited as sensor arrays over micromachined semiconductor substrates with surfaces suitable for high-temperature growth of metal oxides. Beside the ambition of the project is to incorporate the arrays into miniaturised low-power-consumption gas sensing systems equipped with tiny micro-chambers operated in an active sampling mode as micro-reactors. The systems will operate with powerconsumption budgets comparable to a single commercial thick-film gas sensing element, featuring at the same time superior gas distinction, drift compensation as well as self-test functionalities. The NANOS4 proposal is mainly driven by the following markets needs: innovative sub-system technology for increasing safety, comfort and economy of flying in large passenger aircrafts and in vehicles, early detection of smouldering fires, reliable and cost effective monitoring of environmental odour nuisances and workplace safety.

NANOSCALE • • •

Acronym: NANOSCALE Project Title: Understanding interactions between cells and nanopatterned surfaces. Participants: – – – – – – – –



CONSIGLIO NAZIONALE DELLE RICERCHE (CNR-INFM), www.cnr.it , (IT) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) ECOLE NORMALE SUPERIEURE (ENS), , (FR) Glance Vision Technologies s.r.l. (GVT), www.gvt.it , (IT) MULTI CHANNEL SYSTEMS MCS GMBH (MCS), www.multichannelsystems.com , (DE) NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN (NMI), http://www.nmi.de/englisch/welcome.html , (DE) Promoscience srl (Promoscience), www.promoscience.com , (IT) SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI (SISSA), www.sissa.it , (IT)

Project Abstract: The study of biological processes occurring at the nanoscale is becoming a new discipline at the border between Physics and Biology with major scientific challenges and new technological applications. In fact, interactions at the nanoscale between cells/neurons and surfaces with specific nanopatterns appear to control several major biological processes, such as cell proliferation and differentiation. The aim of the present NanoScale proposal is therefore to explore interactions between stem cells, neurons, neuronal networks and surfaces with specific geometrical nanopatterns and nanoprints of specific proteins and molecules. In order to do so, we have formed an interdisciplinary consortium consisting of five major European research centres (SISSA, TASC-INFM, DTU, NMI and ENS) with two SMEs (MCS, Promoscience) gathering biological knowledge and expertise in the fabrication of nanostructures and of their manipulation. The NanoScale proposal will produce and develop a variety of nanodevices for growing, guiding, manipulating cells, neurons and neuronal cultures. It is composed of two major ingredients: i - the combination of a MicroElectrode Arrays (MEAs) with chemical and topographic micro/nanosubstrates controlling the network growth; ii – the coupling with external measuring and/or manipulating devices such as Electron Microscopes and Optical Tweezers. We expect to provide an answer to new scientific issues and therefore achieving major scientific breakthroughs. In addition, our proposal will produce new knowledge and know-how enabling the development of new marketable products that will be commercialised by MCS.

NANOSH • • •

Acronym: NANOSH Project Title: Inflammatory and genotoxic effects of engineered nanomaterials Participants:



Project Abstract: Nanotechnology is a rapidly increasing area of industry providing new and innovative solutions into many industrial sectors. The challenge faced by policy makers and the scientific community is that very little is actually known about the health effects of nanoparticles. It is essential that reliable information should be gathered before these particles enter widespread use to avoid potential health problems induced by the exposure to workers and consumers. The overall goal of this research project is to characterize features of specific engineered nanoparticles, to the delineate levels of exposure in occupational environments, and to explore health effects of exposure to these particles. Exposure levels will be evaluated under laboratory conditions and in occupational environments. The particles will be characterized with respect to their size distribution, solubility, surface activity, and potential for agglomerate formation. Health effects to be studied include genotoxicity and inflammatory responses. Genotoxicity will be assessed in relevant pulmonary cells measuring DNA and chromosomal damage. Inflammatory responses will be evaluated by measuring alterations in the panorama of pulmonary inflammatory cells as well as expression of biochemical markers of inflammation, i.e. cytokines and chemokines in vivo. To assess the effects on the vasculature, the potential of nanoparticles to induce proinflammatory or prothrombotic effects in the microcirculation of experimental animals will be explored.

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CENTRALNY INSTYTUT OCHRONY PRACY - PANSTWOWY INSTYTUT BADAWCZY (CIOP-PIB), www.ciop.pl , (PL) DEUTSCHE GESETZLICHE UNFALLVERSICHERUNG (DGUV), , (DE) TYOETERVEYSLAITOS. (FIOH), www.ttl.fi , (FI) HEALTH AND SAFETY EXECUTIVE (HSE.HSL), http://www.hse.gov.uk , (UK) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMU-MUENCHEN), www.uni-muenchen.de , (DE) NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO (TNO), www.tno.nl , (NL) UNIVERSITY OF LEICESTER (ULEIC), www.le.ac.uk , (UK)

Assuring the safety of new nanomaterials will be a crucial prerequisite for successful promotion of nanotechnological innovations and their applications in the future. This research aims at creating a reliable and sound foundation for the assessment of safety of nanoparticles, and in this way to the project will have a significant impact on the European capability for conducting research and innovation in the area of nanotechnology.

NANOSPEC • • •



Acronym: NANOSPEC Project Title: Nanomaterials for harvesting sub-band-gap photons via upconversion to increase solar cell efficiencies Participants: – – – – – – – –

FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (Fraunhofer ISE), www.fraunhofer.de , (DE) HERIOT-WATT UNIVERSITY (HWU), www.hw.ac.uk , (UK) FORSCHUNGSZENTRUM JUELICH GMBH (IEF5 FZ Juelich), www.fz-juelich.de , (DE) PHILIPS ELECTRONICS NEDERLAND B.V. (Philips), www.philips.com , (NL) TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY. (Technion), www.technion.ac.il , (IL) To be confirmed (Trackdale), , (UK) UNIVERSITAET BERN (Universität Bern), http://www.unibe.ch , (CH) UNIVERSITEIT UTRECHT (Universiteit Utrecht), www.uu.nl , (NL)

Project Abstract: To continue the path of cost reduction in photovoltaics the efficiency of silicon solar cells must be increased. With higher efficiencies more kWh can be produced from the same amount of silicon, which is the dominating cost factor at present. Fundamental loss mechanisms limit the maximum achievable efficiency: around 20% of the incident power is lost, because photons with energies below the band-gap are transmitted. Upconversion of two low energy photons into one usable photon reduces these losses. In this project we will realize upconversion with the help of nanostructures and nanotechnoloy-based materials and show a significant improvement in solar cell efficiency. The combination of upconverting Er-based phosphors with PbSe/PbS core shell quantum dots increases the spectral range of light that is upconverted. The quantum dots will be incorporated into a fluorescent concentrator to achieve concentration within the upconverting device. Both the increased photon flux due to a wider spectral collection and the additional geometric concentration will increase upconversion efficiency because of its nonlinear characteristic. Optical nanostructures shall serve as selectively reflective structures that avoid unwanted parasitic absorption. The development of very efficient quantum dots and suitable host materials, the optimization of the upconverter and the fabrication of photonic structures are main objectives. Additionally, solar cells and system designs will be optimized, to make the best use of upconverted photons. A thorough understanding of the underlying principles is critical for the success, so gaining knowledge about nanostructures and materials is a major goal. The big advantage of this concept is that the solar cells remain fairly unchanged. The proposed concept opens a technology path for an evolutionary development of silicon solar cell technology to efficiencies towards 30%, starting from the solid base of today’s established silicon technology.

NANOSPIN • • •

Acronym: NANOSPIN Project Title: Self-Organised Complex-Spin Magnetic Nanostructures Participants:



Project Abstract: The NANOSPIN project will study complex magnetic nanostructures consisting of a central core with one or more surrounding shells that will be functionalised to self- order on surfaces for applications in classical and quantum ultra-high density information storage. The advanced manufacturing technique we propose uses metal condensation in superfluid He droplets, which is a technology with enormous flexibility. It enables the production of core-shell particles with a free choice of ferromagnetic and antiferromagnetic core and shell materials and an arbitrary number of shells. This degree of control will allow us to engineer the internal spin configuration of an individual nanocluster and to create spin structures that have never been produced before, either naturally or artificially, with a wide range of magnetic properties. The technique will also allow us to coat the nanoparticles with a final shell to promote the ordering of arrays of the designed nanoparticles on surfaces for specific applications. This ability will have an enormous impact on the technological areas of spintronics and magnetic storage. Examples include particles smaller than 5nm that are blocked at room temperature enabling classical data storage densities higher than 10Tb/cm2, and particles embedded in superconducting matrices in states of quantum superposition on which quantum qubits can be stored. Single-particle read/write processes and a new method to erase all data in a nanoparticle assembly using microwaves will be demonstrated. We will also assess the functionalised nanoparticles as qubits in quantum information processing systems. The programme brings together 8 partners from 2 INCO and 6 EU countries. It combines state-of-the-art instrumentation with advances in cluster production technology and will provide the fundamental understanding required to bring highly advanced technologies close to the market.

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CONSIGLIO NAZIONALE DELLE RICERCHE (CNRI), www.cnr.it , (IT) INSTITUTE FOR PHYSICS OF MICROSTRUCTURES OF THE RUSSIAN ACADEMY OF SCIENCES (IPMRU), www.ipm.sci-nnov.ru , (RU) NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS" (NCSRDEL), www.demokritos.gr , (EL) NANOTECHNOLOGY-MDT CO (NTMDTRU), www.ntmdt.ru , (RU) SUMY STATE UNIVERSITY (SSUUA), www.sumdu.edu.ua , (UA) UNIVERSITAT DE BARCELONA (UBES), http://www.ub.es , (ES) UNIVERSITY OF LEICESTER (ULUK), www.le.ac.uk , (UK) THE UNIVERSITY OF READING (URUK), http://www.rdg.ac.uk , (UK) UNIVERSITY OF SURREY (USUK), www.surrey.ac.uk , (UK)

NANO-STRAND • • •

Acronym: NANO-STRAND Project Title: Standardization related to Research and Development for Nanotechnologies Participants:



Project Abstract: The aims of the project are; to develop a road map of the European standardisation and prenormative research work for nanotechnologies and to enable Europe to internationally play an active role in standardisation and nanotechnologies. The objectives are to: Facilitate European industrial development and exploitation Enhance integration between research and production fields Address the different aspects of industrial and consumer health and safety Provide appropriate organisations and structures with information about the needs of the different stakeholders. The project will foster collaboration between national ministries, European and International standardization bodies, European research organisations and industries in numerous nanotechnology sectors. A consortium composed of seven national organisations with complementary skills will deliver the project. A wide range of other organisations will also contribute, including an advisory committee, composed of several European and international experts will review and advise on project progress, a number of stakeholders will attend project workshops to assess industry needs and offer potential solutions and 2,500 selected organisations will be invited to respond a pan-European questionnaire. This inclusive and consultative approach will provide a conduit through which experts, other interested parties and European industries and citizens will influence drafting process of the global standards. The project management and decision making process will ensure that the consortium satisfies the aims of the study, implements the work plan effectively, meets agrees milestones, reports progress and produces comprehensive and current technology roadmaps. To consolidate and widen the potential impact of the project, knowledge developed will be collated for dissemination. All results will be published on a project website and sent directly to stakeholders and the European Commission to inform the development FP VII.

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CESKE VYSOKE UCENI TECHNICKE V PRAZE (CTU IN PRAGUE), www.cvut.cz , (CZ) DIN DEUTSCHES INSTITUT FUER NORMUNG E.V. (DIN E.V.), www.din.de , (DE) LABORATOIRE NATIONAL DE METROLOGIE ET D'ESSAIS (LNE), www.lne.fr , (FR) NPL MANAGEMENT LIMITED (NPLML), www.npl.co.uk , (UK) OPTIMAT LIMITED (OPT), , (UK)

NANOTEMPLATES • • •



Acronym: NANOTEMPLATES Project Title: Templates for Engineered Nano-Objects for use in Microwave, Electronic Devices and Biomedical Sensing Applications Participants: – – – – – – –

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (CNRS), www.cnrs.fr , (FR) CENTRO RICERCHE FIAT SCPA (CRF), www.crf.it , (IT) UNIVERSITY OF DURHAM (DURHAM), , (UK) EPIGEM LIMITED (EPIGEM), www.epigem.co.uk , (UK) THALES SA (TRT-FR), www.thalesgroup.com , (FR) UNIVERSITE CATHOLIQUE DE LOUVAIN (UCL), www.uclouvain.be , (BE) UNIVERSITY OF NEWCASTLE UPON TYNE (UNEW), www.newcastle.ac.uk , (UK)

Project Abstract: NanoTemplates STREPS project will push the Frontiers of Science of a unique range of nanoobjects made by further extending nanotechnology developed in two EU RTD projects [NanoPTMS & GMR - BE951761 & NanoPTT - G5RD -CT1999-00135]. It will seek advantageous property discontinuities arising from the nano-regime and explore these through a range of novel nano-systems to identify promising areas for further development. The project will be underpinned by IPR from previous EC projects employing UCL technology based on heavy ion bombardment and track etching of polymers for nano-object fabrication. Fundamental studies of the track etching and patterning processes will be made. Nanoporous substrates (pores down to 10nm), polymeric and metallic nanowires and nanotubes in various forms (Nano-objects), including particulate and embedded within coatings and self-supporting films, will be developed (UCL, Epigem, CNRS). Alternative route to nanoporous arrays will also be investigated by using AFM tip generation of pores (CNRS) in spin-coated films. The characterisation of the nano-objects will be performed and specific properties will be measured. It is intended to screen optical, magnetic and chemical properties. The response of magnetic metallic nanowire arrays to high frequency fields will be investigated (Thales, UCL), whilst CRF and Thales will explore the magnetic properties of the nano-structures. Spin dependent phenomena in magnetic nano-objects will be investigated by UCL and CNRS to explore ultimate limits of magnetoresistive effects and potential long- term applications to quantum computing. UNEW and Epigem will integrate nano-objects in microfluid nanosystems and measure biomedical properties. CRF and Durham will explore nano-objects in the form of light sources comprising light emitting polymer diodes (OLED). Confinement effects will be explored to identify benefits for the emission spectrum as well as the light extraction mechanism.

NANOTHER • • •



Acronym: NANOTHER Project Title: Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer Participants: – – – – – – – – – – – – – – – – – –

AHAVA DEAD SEA LABORATORIES LTD (AHAVA), , (IL) ALMA CONSULTING GROUP SAS (ALMA), www.almacg.com , (FR) ARGUS CHEMICAL SRL (ARGUS), www.argus.it , (IT) CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS (CICbio), www.cicbiogune.es , (ES) COLOROBBIA ITALIA SPA (COLORITA), , (IT) DOMINION PHARMAKINE S.L. (DPK), www.pharmakine.com , (ES) FEYECON DEVELOPMENT & IMPLEMENTATION BV (FEYECON), , (NL) FUNDACION GAIKER (Gaiker), www.gaiker.es , (ES) HAMELN RDS AS (HAMELN), www.hameln-rds.com , (SK) CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI (INSTM), www.instm.it , (IT) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) Institut polytechnique de Bordeaux (LCPO), , (FR) NuovoProbe Ltd (NUOVO PROBE), , (UK) PHARMAMAR, S.A.U. (PHMAR), , (ES) UNIVERSITE VICTOR SEGALEN BORDEAUX II (RMSB), , (FR) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) TECHNOLOGICAL EDUCATIONAL INSTITUTION OF ATHENS (TEIA), , (EL) ASOCIACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES-VICOMTECH (VC), , (ES)

Project Abstract: The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The nanoparticles used in NANOTHER will be selected based on previous studies. Therefore, only polymeric micelles core-shell nanoparticles and magnetic nanoparticles will be included in the study. The nanoparticles will be functionalised by attaching targeting molecules, depending on the type of cancer to be treated or diagnosed. Labels for diagnosis will include fluorescent or contrast phase probes, which will later be imaged and analysed with the appropriate equipment optimised during the project. Therapeutic agents will be loaded on to the nanoparticle, including drugs like doxorubicin, and new marine pharmacological compounds already in clinical trials. One of the most innovative aspects of this proposal is the use of siRNA as the therapeutic agent. The use of magnetic nanoparticles as a theranostic mechanism is also an innovative aspect of the proposal, as these nanoparticles can be activated to kill tumour cells detected depending on a positive or negative diagnostic. The project has been structured in seven different sub-projects including aspects like toxicology, biocompatibility of the nanodevices, and also efficacy and biodistribution of the system. In vitro (cellular models) & in vivo assays (small animals; mice) will be used for the study of diagnosis & therapy. The latter will be kept to the minimum necessary to study the efficiency & biodistribution and always taking into account the three Rs & national / EU norms. The NANOTHER consortium includes 18 top-level partners from 8 EU countries as the critical mass required to achieve ambitious project objectives.

NANOTOTOUCH • • •

Acronym: NANOTOTOUCH Project Title: Nanosciences Live in Science Centres and Museums Participants:



Project Abstract: The NANOTOTOUCH proposal aims to create innovative environments for the broad public to learn about and to discuss nano research by directly involving the actors of research themselves. We propose to do this by taking the laboratory environment and the research work out of enclosed academic campuses and relocating them right in the midst of the public in science museums and science centres. Three science museums and three science centres will closely cooperate with local university partners to create three permanent Open Nano Lab locations (in Munich, Milan and Gothenburg) and three Nano Researcher Live areas (in Mechelen, Tartu and Naples). In these places the visitors will experience “live” the day-to-day practices and processes of nano research conducted by young scientists. This peer-to-peer dialogue on an equal basis between lay public and nano-researchers not only creates a bidirectional feedback, it also minimises the expert-to-lay bias (“top-down" approach) inherent present science communication processes with authoritative top researchers. In order to prepare the young scientists for this novel method of communication, NANOTOTOUCH also includes a strong communication skills training component. NANOTOTOUCH will also establish new role models for choosing science as a career: young adults thinking of entering science will be able to discuss various aspects with young researchers who themselves made this decision recently, whilst upcoming researchers will learn that communication is a self-evident part of their professional identity. Thus, NANOTOTOUCH pushes science communication to its extreme, merging communication and research in a powerful way and responding to the need for more transparency and accessibility in science. Furthermore, the strong synergetic network approach of the project enables contents and models to be developed for further distribution and implementation in educational and scientific communities.

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SIHTASUTUS TEADUSKESKUS AHHAA (AHHAA), www.ahhaa.ee , (EE) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) CHALMERS TEKNISKA HOEGSKOLA AB (CUT), www.chalmers.se , (SE) DEUTSCHES MUSEUM VON MEISTERWERKEN DER NATURWISSENSCHAFT UND TECHNIK (DM), www.deutsches-museum.de , (DE) Association Européenne des Expositions Scientifiques, Techniques et Industrielles (Ecsite), www.ecsite.net , (BE) Fondazione IDIS-Città della Scienza (IDIS), www.cittadellascienza.it , (IT) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMU), www.uni-muenchen.de , (DE) FONDAZIONE MUSEO NAZIONALE DELLA SCIENZA E DELLA TECNOLOGIA LEONARDO DA VINCI (MUST), www.museoscienza.org , (IT) Technopolis (Technopolis), www.technopolis.be , (BE) TECHNISCHE UNIVERSITAET MUENCHEN (TUM), www.tu-muenchen.de , (DE) UNIVERSITEIT ANTWERPEN (UA), www.ua.ac.be , (BE) UNIVERSITA DEGLI STUDI DI MILANO (UMIL), www.unimi.it , (IT) UNIVERSEUM AB (Universeum), www.universeum.se , (SE) TARTU ULIKOOL (UTARTU), www.ut.ee , (EE)

NANOTOX • • •



Acronym: NANOTOX Project Title: Investigative Support for the Elucidation of the Toxicological Impact of Nanoparticles on Human Health and the Environment Participants: – – – – – – – – –

INSTITUTE OF INFORMATION TECHNOLOGIES OF THE BULGARIAN ACADEMY OF SCIENCES (BAS), www.bas.bg , (BG) CHALEX RESEARCH LTD (CHALEX), www.chalex.co.uk , (UK) CMP CIENTIFICA S.L. (CMPC), www.cmp-cientifica.com , (ES) CONSORZIO INTERUNIVERSITARIO PER LO SVILUPPO DEI SISTEMI A GRANDE INTERFASE (CSGI), www.csgi.unifi.it , (IT) TEKNILLINEN KORKEAKOULU (HUT), www.tkk.fi , (FI) MBN NANOMATERIALIA SPA (MBN), www.mbn.it , (IT) NANOCYL S.A. (NANOCYL), www.nanocyl.com , (BE) INSTYTUT MEDYCYNY PRACY NOFERA (NOFER), www.imp.lodz.pl , (PL) THE UNIVERSITY OF MANCHESTER (UMAN), www.manchester.ac.uk , (UK)

Project Abstract: The global aim of this project is to provide investigative support for the elucidation of the toxicological impact of nanoparticles on human health and the environment. It is aimed at area 3.4.1.5. of the Nanotechnologies and Nanosciences, Knowledge Based Multifunctional Materials, New Production Processes and Devices work programme. Public organisations and nanotechnology companies across Europe are under pressure to improve the safety of nanoparticles. In this project, they will document potential methods of dispersal and contamination by nanoparticles and agglomerated nanocrystals (e.g. sorption, desorption, transport, aggregation, deposition, bio-uptake). The review will also address the following issues: a)physical and chemical properties of different types of nanoparticles and agglomerated nanocrystals; b)manufacturing and use; c)human health effects including side effects; d)animal toxicology; e)environmental impacts; f)mutagenicity/genotoxicity; g)metabolism/pharmacokinetics; h)standards for safe use; i)safe laboratory methods etc. Current research and development activities in Europe will be mapped and entered onto an on-line European database, which will be linked to existing web sites and databases of specialist groups. Standards, legislation, ethical issues, policies and codes of practice, at international and European level, which have been put in place or are under development, will be assessed and reviewed. Their implications and effectiveness will be discussed. Ways in which existing legislation is applied to the macroscale counterparts of nanoparticles will also be examined. Guidelines and recommendations for the institution of future European standards, legislation, ethics, policies, and codes of practise, for the safe production and use of nanoparticles will be produced. All potential impacts revealed by this SSA will be documented in the final report & disseminated via the specialised webpages on the Nanoforum & Nanotox websites.

NANOTRANSPORT • • •

Acronym: NANOTRANSPORT Project Title: The Behaviour of Aerosols Released to Ambient Air from Nanoparticle Manufacturing - A Pre-normative Study Participants:



Project Abstract: The NANOTRANSPORT project addresses the behaviour of aerosols released to ambient air from nanoparticle manufacturing. The project brings together leading expert organisations in risk management, aerosol monitoring, filtration, nanoparticle technology and online particle characterization fields. The proposed pre-normative study has the objective of bringing into light and to document the need for standardised test aerosols adapted to the scope of nanotoxicology and occupational health studies. State-of-theart nanoparticle generation and aerosol monitoring equipment will be used to show that the properties (size, size distribution, surface chemistry, surface charge, concentration?) of aerosols formed by manufactured nanoparticles experience dramatic changes when released in the ambient air compared to their initial properties within the reactor. The project will provide introductory experimental results that will be used to develop recommendations and guidelines for the European Commission. Based on NANOTRANSPORT results, the Commission will have the necessary background to prioritise and initiate research to -Develop standard test aerosols adapted to specific studies/tests/validations/investigations o It will contribute to determine the toxicological and epidemiological hazards posed by nanopowders in a systematic way reflecting exposure levels likely to be encountered in industry o New standards and particularly adequate test aerosols for testing and guaranteeing suitability of filtration and respiratory protection for use in nanoparticles/nanopowders production or processing sites will be identified and described. -Promote a more effective use of research funding by implanting correct methodologies that will contribute to provide meaningful and comparable results which will o Help the development of risk assessment tools for released nanoparticles o Help gaining public and stakeholder acceptance regarding safe production and use of manufactured nanopar

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DET NORSKE VERITAS AS (DNV), www.dnv.com , (NO) GRIMM AEROSOL TECHNIK GMBH & CO KG (GRIMM), www.grimm-aerosol.com , (DE) UNIVERSITAET KARLSRUHE (TECHNISCHE HOCHSCHULE) (UNIK), www.uni-karlruhe.de; www.kit.edu , (DE)

NANO-TV • • •

Acronym: NANO-TV Project Title: Enhancing public awareness on the results of European research actions on Nanosciences and Nanotechnologies through the professional use of television media and the internet Participants: – – – –



GEDEON PROGRAMMES SA (Gedeon), , (FR) ICONS S.R.L. (iCons), http://www.icons.it , (IT) INSTITUTE OF NANOTECHNOLOGY (IoN), www.nano.org.uk , (UK) LEONARDO FILM GMBH (Leonardo), , (DE)

Project Abstract: The strategic objective of NANO-TV is "TO CONTRIBUTE TO THE DEVELOPMENT OF PUBLIC AWARENESS ON EUROPEAN RESEARCH ON NANOSCIENCES AND NANOTECHNOLOGIES IN ALL EUROPEAN COUNTRIES THROUGH THE PROFESSIONAL USE OF TELEVISION MEDIA AND THE INTERNET". The project will: • Highlight the key results from the Nanotechnologies Theme. • Create a series of 14 high-quality free-of-rights Video News Releases (VNRs) for the general public on the basis of the key results of the research. • Include all 14 released VNRs into the broadcasting mainstream of the European TV stations by implementing a consolidated communication model involving the totality of the national European TV media. • Establish a sound science-based dialogue on nano issues by introducing all released VNRs and the associated written materials (articles, press releases, etc.) into a series of highly references internet platforms. • Monitor the results of the project and assess its achievements and success, by assessing the overall impact of the project and collecting actual broadcasts made by European TV stations and include them on a DVD at the end of the project, for future use and exploitation. The expected measurable results of NANO-TV are: • To have each of its audiovisual production broadcast by at least 10 major national TV stations throughout Europe. • To reach an overall public TV audience of several tens of millions people. • To track as many broadcasts as possible and to retrieve, for each broadcast, broadcasters’ edit. • To provide a measure of the overall media impact of the project.

NANOYOU • • •

Acronym: NANOYOU Project Title: Communicating NANOtechnology to European YOUth Participants:



Project Abstract: NANOYOU will design and undertake a communication and outreach program in nanotechnology (NT) aimed at European youth. The project will reach 11-18 year olds through school programs to take place in at least 20 EU Member States and Associated States. Additional programs aimed at young adults aged 19-25 will be offered in science centres. The school programs are planned to involve at least 400 schools and reach more than 25,000 students. The science centres program is expected to reach an initial 4,000 young adults during NANOYOU and many more subsequently as more science centres adopt the program. Recent surveys show that most European citizens have poor understanding of NT, its potential and risks. This needs to be rectified if the European public is to contribute positively to future decision-making about the use of NT. In focusing on ages 11-25, NANOYOU recognizes that effective programming needs to be tailored to the educational capabilities and interests of the target population. Programming specialization will be provided for subgroups within this youth population. While some FP6 programs have made an excellent start in informing the public about NT, they have not focused on youth nor have their activities taken places in the schools. NANOYOU will combine temporary exhibitions, innovative computer games, experiments and other online content, with workshops aimed at promoting dialogue that will raise participants' awareness of ethical, legal and societal aspects of NT. NANOYOU's content will be balanced and up-to-date, and teacher training materials will be prepared to equip science teachers and other personnel to present the NANOYOU programs. NANOYOU has assembled a strong consortium with partners experienced in nanotechnology, educational methodology and science communication, as well as organizations highly suited and experienced at arranging outreach/communication activities in schools and science centres

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ARTTIC ISRAEL INTERNATIONAL MANAGEMENT SERVICES 2009 LTD (AIIMS2L), , (IL) CENTRE CULTUREL SCIENTIFIQUE ET TECHNIQUE (CCSTI Grenoble), www.ccsti-grenoble.org , (FR) CITE DES SCIENCES ET DE L'INDUSTRIE (CSI), www.cite-sciences.fr , (FR) EUN Partnership AISBL (EUN), www.europeanschoolnet.org , (BE) AARHUS UNIVERSITET (iNANO-AU), www.au.dk , (DK) ORT ISRAEL (ORT), , (IL) FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA (PCB), www.pcb.ub.es , (ES) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UCAM), www.cam.ac.uk , (UK) ZENTRUM FUER SOZIALE INNOVATION (ZSI), http://www.zsi.at , (AT)

NAPA • • •

Acronym: NAPA Project Title: Emerging Nanopatterning Methods Participants: – – – – – – –

GESELLSCHAFT FUR ANGEWANDTE MIKRO UND OPTOELEKTRONIK MIT BESCHRANKTERHAFTUNG AMO GMBH* (AMO), www.amo.de , (DE) BIOSENSIA LIMITED (BIOSENSIA), , (IE) FUNDACION CIDETEC (CIDETEC), www.cidetec.es , (ES) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CNM), http://www.csic.es , (ES) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) CENTRO RICERCHE FIAT SCPA (CRF), www.crf.it , (IT) CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT (CSEM), www.csem.ch , (CH)

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ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) EV GROUP E. THALLNER GMBH (EVG), www.evgroup.com , (AT) IBM RESEARCH GMBH (IBM), www.zurich.ibm.com , (CH) INSTITUTE OF MICROELECTRONICS TECHNOLOGY RAS (IMT), www.ipmt-hpm.ac.ru , (RU) FUNDACION INASMET (INASMET), http://www.inasmet.es , (ES) CONSIGLIO NAZIONALE DELLE RICERCHE (IPCF), www.cnr.it , (IT) COMMISSARIAT A L' ENERGIE ATOMIQUE (LETI), www.cea.fr , (FR) LINKOPINGS UNIVERSITET (LIU), www.liu.se , (SE) LUNDS UNIVERSITET (LU), www.lu.se , (SE) UNIVERSITEIT TWENTE (MESA+), www.utwente.nl , (NL) DANMARKS TEKNISKE UNIVERSITET (MIC), www.dtu.dk , (DK) MICRO RESIST TECHNOLOGY GESELLSCHAFT FUER CHEMISCHE MATERIALIEN SPEZIELLER PHOTORESISTSYSTEME MBH (MRT), www.microresist.de , (DE) NANOPLUS NANOSYSTEMS AND TECHNOLOGIES GMBH (NANOPLUS), , (DE) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (NMRC), www.ucc.ie , (IE) NPL MANAGEMENT LIMITED (NPL), www.npl.co.uk , (UK) OBDUCAT AKTIEBOLAG* (OBD), www.obducat.com , (SE) PAUL SCHERRER INSTITUT (PSI), www.psi.ch , (CH) SMART EQUIPMENT TECHNOLOGY SAS - S.E.T SAS (SET), www.set-sas.fr , (FR) SUSS MICROTEC SAS (SMT SAS), www.suss.com , (FR) SUSS MICROTEC LITHOGRAPHY GMBH (SUSS), www.suss.com , (DE) CONSIGLIO NAZIONALE DELLE RICERCHE (TASC), www.cnr.it , (IT) FUNDACION TEKNIKER (TEKNIKER), www.tekniker.es , (ES) UNIVERSITY OF GLASGOW (UG), www.gla.ac.uk , (UK) VALTION TEKNILLINEN TUTKIMUSKESKUS (VTT), www.vtt.fi , (FI) POLITECHNIKA WARSZAWSKA (WUT), http://www.pw.edu.pl , (PL)

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NAPA cont. •

Project Abstract: The growing importance of nanotechnology for the European Research Area is reflected in the FP6 Thematic Priorities. It is foreseen that most of the projects submitted to the Priority Area 3 (NMP) will need and develop nanopatterning techniques in one way or another. The Emerging Nanopatterning Methods (NaPa) consortium integrates the new patterning methods into one project, both anticipating and responding to the increasing need for technologies, standards and metrology required to harness the new application-relevant properties of engineered structures with nm-scale features. The NaPa consortium complements the deep UV technology by providing low-cost scalable processes and tools to cover the needs of nanopatterning from CMOS back-end processes through photonics to biotechnology. To achieve this, research in three technology strands is proposed: nanoimprint lithography, soft lithography & self-assembly and MEMS-based nanopatterning. While the former is at a crucial embryonic stage, requiring prompt consolidation to yield its first products in one or two years, the other two will result in applications towards the end of the project. Research in three overarching themes required by all strands: Materials, Tools and Simulation will be undertaken. NaPa brings together 35 leading academic and industrial European institutions with a vast amount of recent know-how on nanofabrication, partly developed within FP5. In total, 3500 person months will be contributed by the partners to the project. Complementing R&D, the consortium will design exciting nanoscience and nanoengineering courses to advance the training of the next generation of scientists and engineers and to create a positive attitude towards science among young people. Dissemination activities towards the lay public and sectors underrepresented in nanotechnology form an integral part in NaPa.

NASCENT • • •

Acronym: NASCENT Project Title: SILICON NANODOTS FOR SOLAR CELL TANDEM Participants: – – – –

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To be confirmed (AZUR), , (DE) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR-IMM), www.cnr.it , (IT) UNIVERZITA KARLOVA V PRAZE (CUNI), www.cuni.cz , (CZ) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER ISE), www.fraunhofer.de , (DE) ALBERT-LUDWIGS-UNIVERSITAET FREIBURG (IMTEK), www.uni-freiburg.de , (DE) UNIVERSITAT DE BARCELONA (MIND-UB), http://www.ub.es , (ES) STMICROELECTRONICS SRL (STM), www.st.com , (IT) UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA (UNIMORE), www.unimore.it , (IT)

Project Abstract: The overall objective of the proposed project is to develop new Nanomaterials with New Production Technologies and to fabricate silicon quantum dot tandem solar cells to achieve increased efficiencies. The understanding of electrical transport and recombination mechanisms in these newly developed nanomaterials will enable us to design new tandem solar cell structures - based on Si thin-film or wafer solar cells - that help to overcome the efficiency limits of these conventional concepts. In order to reach our goals, considerable R+D work has to be performed on semiconductor bulk materials, thin layers and hetero-structures for such solar cells. These topics have not yet or only in parts been investigated and are also of high scientific interest for novel photonic and charge storage devices incorporating Si nanocrystals embedded in Si alloys. The consortium of this project, also including two companies, merges the scientific and technological competences that are necessary to find answers to these questions. Another objective is the compatibility of the newly developed technologies with high-throughput processing to ensure further cost-reduction. The expected significant jump in the solar cell and processing evolution will lead to higher efficiencies for solar cells and to ongoing cost-reduction also with a longterm perspective and will help to strengthening the European leadership in PV technologies. Thus it will also have a positive impact on the acceptance of photovoltaics by the public and by politics. Moreover, since “energy efficiency” is a big subject in the public discussion, photovoltaics will be an example of one of the highest electricity production efficiencies that have been achieved of all power generators. To sum up, we believe that this project will have a direct and positive impact on the European PV industry and its status in material science and it will contribute to the very ambitious goals of the EU commission in CO2 reduction in general.

NAS-SAP • • •

Acronym: NAS-SAP Project Title: Nano Arrayed Systems based on Self Assembling Proteins Participants:



Project Abstract: In contrast to 'top down' fabrication, biology makes low cost replicable and precise nanosystems using 'bottom up' self assembly. We propose to develop a platform self assembling nanoarray system using proteins from 2 microbial structures: SPORE COATS and S-LAYERS. SPORE COATS form the protective shell of bacterial endospores, S-LAYERS the surface layer of most bacteria. Both have protective properties and consist of self-assembled protomers forming extremely uniform paracrystalline surfaces with hexagonal, square or oblique patterns and unit distances of several nanometres. The surfaces can be homogeneous or heterogeneous can impose nanostructure on to other elements. There are 9 research partners from 6 EU plus 1 ACC state. Two partners are SMEs with established interests in nanobiotechnologies for industry who will exploit commercial opportunities from this 3 year research program. It has a strong set of partners with worldwide expertise in Slayers, bacterial spores, nanoimaging, protein engineering and structure analysis, plus strong management from an SME. The longterm objectives are to develop methodologies and IP for exploitation of bacterial surface structures and components for nanoengineering. This fits well with the guidelines for STREP activities. We propose to: *Dissect and understand the processes that build bacterial Spore Coats and S-Layers *Optimise for self assembly on planar, 3D and particle surfaces with several array geometries *Develop homogeneous and heterogeneous nanoarrays *Develop and understand techniques needed to couple arrays to organic and inorganic components supporting application development *Build a portfolio of IP covering the core platform, its coupling to effectors and its use, by developing prototype applications-biocatalysis, biosensors, immunogens, drug delivery and metallic nanoarrays

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UNIVERSITAET FUER BODENKULTUR WIEN (CNB/BOKU), www.boku.ac.at , (AT) USTAV MOLEKULARNEJ BIOLOGIE, SLOVENSKA AKADEMIA VIED (IMB SAS), http://imb.savba.sk/ , (SK) IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (IMPERIAL), www.imperial.ac.uk , (UK) UNIVERSITAET LINZ (JKU), , (AT) NANO-S BIOTECHNOLOGY GMBH (NANO-S), www.nano-s.com , (AT) ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE (RHUL), , (UK) SIQUED GEOLOGISCHE CONSULTING (SIQUED), www.siqued.de , (DE) UNIVERSITE DE BORDEAUX I (U-BDX1), www.u-bordeaux1.fr , (FR) HELSINGIN YLIOPISTO (UNI. HELSINKI), http://www.helsinki.fi/university/ , (FI)

NEPHH • • •



Acronym: NEPHH Project Title: NANOMATERIALS-RELATED ENVIRONMENTAL POLLUTION AND HEALTH HAZARDS THROUGHOUT THEIR LIFE-CYCLE Participants: – – – – – – – – – –

ASOCIACION PARA LA PREVENCION DE ACCIDENTES (APA), , (ES) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) CRANFIELD UNIVERSITY (CRAN), www.cranfield.ac.uk , (UK) POLITECHNIKA KRAKOWSKA (CUT), www.transfer.edu.pl - www.pk.edu.pl - www.krakow-info.com , (PL) EKOTEK INGENIERI Y CONSULTORIA MEDIOAMBIENTAL (EKOTEK), www.ekotek.es , (ES) GRADO ZERO ESPACE SRL (GZE), www.gzespace.com , (IT) Palladin Institute of Biochemistry (IBC), http://www.biochemistry.org.ua , (UA) FUNDACION INASMET (INASMET), http://www.inasmet.es , (ES) LAVIOSA CHIMICA MINERARIA SPA (LAVIOSA), www.laviosa.it , (IT) TOMSK POLYTECHNIC UNIVERSITY (TPU), http://www.tpu.ru , (RU)

Project Abstract: The purpose of this project is to identify and rate important forms of nanotechnology-related environmental pollution and health hazards that could result from activities involved in nano-structures throughout their life-cycle, and to suggest means that might reduce or eliminate these impacts. Besides the positive multipurpose nano-reinforcement in materials and expanded devices applications, little is known about the environmental and health risks of certain manufactured nanomaterials. Initial research has indicated that nanomaterials can have a negative impact on human health and environmental pollution. For instance, carbon nanotubes may be more toxic than other carbon particles or quartz dust when being absorbed into the lung tissue; however, specific detailed research is required. More importantly, and fundamental to the success of nanotechnology, is the perceived safety of the technology by the public. As activity shifts from research to the development of applications, there exists an urgent need to understanding and managing the associated risks, but in particular to personnel working with these materials. To address these issues, an investigation of biological interactions of nanoscale and nanostructured materials on in vitro toxicological mechanisms is proposed. Further, an assessment of their impact on environmental pollution regarding water, soil and air is also proposed.

NEURONANO • • •

Acronym: NEURONANO Project Title: Do nanoparticles induce neurodegenerative diseases? Understanding the origin of reactive oxidative species and protein aggregation and mis-folding phenomena in the presence of nanoparticles Participants: –

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HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH (GSF), www.helmholtzmuenchen.de , (DE) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (IHCP), http://www.jrc.ec.europa.eu , (BE) Instituto Nacional de Pediatria (INP), http://www.salud.gob.mx/unidades/pediatria/ , (MX) NATIONAL INSTITUTE FOR MATERIALS SCIENCE (NIMS), , (JP) WILLIAM MARSH RICE UNIVERSITY (RU), www.rice.edu , (US) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (UCC), www.ucc.ie , (IE) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (UCD), www.ucd.ie , (IE) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (UCLA (University of California, Los Angeles)), , (US) THE UNIVERSITY OF EDINBURGH (UEDIN), www.ed.ac.uk , (UK) E FEDERAL DO CEARA (UFC), http://www.ufc.br , (BR) UNIVERSITY OF ROCHESTER (UR), www.urmc.rochester.edu , (US) UNIVERSITY OF ULSTER (UU), www.ulster.ac.uk , (UK)

Project Abstract: As the use of nanoparticles becomes more prevalent, it is clear that human exposure will inevitably increase. Considering the rapidly ageing European population and the resulting increase in the incidence of neurodegenerative diseases, there is an urgent need to address the risk presented by nanoparticles towards neurodegenerative diseases. It is believed that nanoparticles can pass through the blood-brain barrier. Once in the brain, nanoparticles have two potential major effects. They can induce oxidative activity (production of Reactive Oxygen Species), and can induce anomalous protein aggregation behaviour (fibrillation). There are multiple disease targets for the nanoparticles, including all of the known fibrillation diseases (e.g. Alzheimer’s and Parkinson’s diseases). The factors that determine which nanoparticles enter the brain are not known. Nanoparticle size, shape, rigidity and composition are considered important, and under physiological conditions, the nature of the adsorbed biomolecule corona (proteins, lipids etc.) determines the biological responses. The NeuroNano project will investigate the detailed mechanisms of nanoparticle passage through the blood-brain barrier using primary cell co-cultures and animal studies. Using nanoparticles that are shown to reach the brain, we will determine the mechanisms of ROS production and protein fibrillation, using state-of-theart approaches such as redox proteomics and isolation/characterisation of the critical pre-fibrillar species. Animal models for Alzheimer’s diseases will confirm the effects of the nanoparticles in vivo. At all stages the exact nature of the nanoparticle biomolecule corona will be determined. The result will be a risk-assessment framework for assessing the safety of nanoparticles towards neurodegenerative diseases, based on the connection of their biological effects to their biomolecule corona, which determines the biological response in vivo and reports on the nanoparticles’ history.

NEURONANO • • •



Acronym: NEURONANO Project Title: Towards new generations of neuro-implantable devices: engineering NEUROns/carbon NANOtubes integrated functional units Participants: – – – – – –

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), www.epfl.ch , (CH) SZILARDTESTFIZIKAI ES OPTIKAI KUTATOINTEZETE - MAGYAR TUDOMANYOS AKADEMIA (HAS), www.szfki.hu , (HU) THE HEBREW UNIVERSITY OF JERUSALEM. (HUJI), www.huji.ac.il , (IL) MULTI CHANNEL SYSTEMS MCS GMBH (MCS), www.multichannelsystems.com , (DE) UNIVERSITA DEGLI STUDI DI TRIESTE (UNITS), www.units.it , (IT)

Project Abstract: The NEURONANO network proposes to integrate carbon nanotubes (CNT) with multielectrode array (MEA) technology to develop new generation biochips to help repair damaged central nervous system (CNS) tissues. This objective will be reached by adopting a multi-disciplinary approach and by crossing the boundaries among Materials Science, Nano and Microtechnology, and Neuroscience. The impact of carbon nanotubes on multielectrode array (MEA) technology and therefore on neuro-implant technology represents a first step toward CNS nanoengineering. Our approach is to push ahead the application and functionalization of carbon nanotubes in the CNS by focusing on CNT chemistry, peptide and surface chemistry and two complex networks in cultures: the spinal cord (locomotor networks) and brain (hippocampus and neocortex networks). We will concentrate on the complex electrical activity of these networks once grown on implantable substrates. We are specifically interested in understanding how the components underlying electrical activity are organized when implemented with semiconductive substrates, and how this organization changes in the presence of molecular cues or chronic stimulations. The research plan has three major aims: i) to answer fundamental questions about the biophysical interactions between nnanomaterials and neurons ii) to exploit carbon nanotubes in the presentation of positive and negative cues, thus providing specific molecular environment to favor axonal regeneration and retargeting; iii) to develop the characterization of novel MEA/nanotube integrated devices, for multi-site extracellular stimulation and recording.

NEWTON • • •



Acronym: NEWTON Project Title: Enabling Technologies for 3D Nano Photonics: New Materials and Process Technology for Real 3D Integrated Optical Circuits, Photonic Band Gap Devices and Photonic Crystals Participants: – – – – – –

BASF SE (BASF), www.basf.com , (DE) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) INSTITUT TELECOM (GET/ENSTB), www.institut-telecom.fr , (FR) LASER ZENTRUM HANNOVER E.V. (LZH), www.lzh.de , (DE) PHOTON DESIGN LTD (PD), www.photond.com , (UK) THALES SYSTEMES AEROPORTES S.A. (TAS), , (FR)

Project Abstract: Photonic crystals and photonic band gaps (PBG) represent a new class of optical devices for guiding and processing light. Conventional optic relies on effects like reflection (mirrors, Bragg reflection), refraction (lenses, prisms) or diffraction (gratings). In PBG devices the interaction of light is based on "optical bandgaps" in crystals, suppressing certain wavelengths to propagate in pre-determined directions. With the implementation of photonic band gaps in optical systems, new applications for processing light are feasible, existing optical functions can be build up with much smaller dimensions (< 1 mm³), and higher integration density can be achieved. In this project, a material and process technology will be developed which allows the fast and flexible production of real 3-dimensional photonic crystals. Only as 3-dimensional systems, PBGs can exploit their full theoretical capabilities. The manufacturing approach will be achieved by the combination of research activities on (i) polymer based nano-scale colloids, (ii) holographic structured polymers, (iii) laser based defect inscribing into the material with nm-resolution, (iv) infiltration and inversion techniques to realise photonic crystals, and the (v) full characterisation and performance evaluation of the manufactured components. In parallel, (vi) simulation and design tools for of PBGs will be improved and adapted to the manufacturing technology for a fast realisation of the devices and better understanding of influencing factors in the manufacturing process. First test devices will include basic optical functions like wave guides, splitters, filters for telecom applications. On the long term, this technology will contribute to optical integrated circuits and self routing in meshed communication networks. At this stage it can be anticipated that photonic crystals are essential for future alloptical computing, having the same impact in optical engineering as semiconductors and CMOS had in electronics

NHECD • • •

Acronym: NHECD Project Title: Nano Health-Environment Commented Database Participants: – – – –



IVAM UVA (IVAM), www.ivam.uva.nl , (NL) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) TP21 GMBH (TP21), www.tp21.de , (DE)

Project Abstract: Nanotechnology is a fast growing industry producing a wide variety of manufactured nanomaterials (MNMs) and numerous potential applications. Consequently, the potential for exposure to humans and the environment is likely to increase. Human exposure to MNMs and environmental release of these materials can occur during all the life cycle stages of these materials. For each stage of the life cycle of an MNM, exposure scenarios will need to be developed that effectively describe how exposure to humans and the environment occur and what measures are required to control the exposure. The aim of the NANEX project is to develop a catalogue of generic and specific (ocupational, consumer and environmental release) exposure scenarios for MNMs taking account of the entire lifecycle of these materials. NANEX will collect and review available exposure information, focussing on three very relevant MNMs: (1) high aspect ratio nanomaterials - HARNs) (e.g. carbon nanotubes); (2) mass-produced nanomaterials (e.g. ZnO, TiO2, carbon black); and (3) specialised nanomaterials that are currently only produced on a small scale (e.g Ag)). The exposure information will include both quantitative (measurement results) and qualitative contextual exposure information (risk management measures). We will also review the applicability of existing models for occupational and consumer exposure assessment and for environmental release from these scenarios. We will carry out a small number of specific case illustrations and carry out a gap analyses of the available knowledge and data. Finally, we project knowledge will be disseminated to relevant stakeholders, taking into account other relevant activities that are taking place in this field.

NINIVE • • •

Acronym: NINIVE Project Title: NON INVASIVE NANOTRANSDUCER FOR IN VIVO GENE THERAPHY Participants:



Project Abstract: Nanotechnology is expected to have a major impact on biomedical research, leading to new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is the development of nonviral vectors for safe and efficient gene delivery. Progress in the Human Genome Project increases the attractiveness of gene therapy as a therapeutic modality for a host of diseases. Today the methodologies for in vivo gene transfection are still in their infancy. The most promising method is based on the use of viral vectors, but its safety is actually under discussion. This project aims at developing a nonviral vector for gene delivery, able of a) gene transfection in vivo and on a large amount of cells, b) local and non invasive therapy, c) frequent and easy medication. This nano-device will be based on a carbon nanotube (CNT). It will be coated with genes to be transfered, and will be functionalized with a ligand, able to bind a receptor expressed by the target cells to be transfected. A solution containing a myriad of vectors will be dispensed locally in the target tissue, e.g. via injection; each of them will localise a target cell and bind it. Two strategies of cell transfection will be investigated: 1) cells up-take the vectors via endocytosis and 2) genes are transferred in the cell membrane via electroporation (i.e. via permeabilization of cell membrane by application of short-duration electric field pulses). In the second case, current impulses could be generated in CNTs via electromagnetic fields, by exploiting the properties of CNTs like antennas. In order to prove these paradigms, in vivo validation of the nanotransducer vectors will be performed. A specific neurological disorder will be treated to demonstrate their therapeutic potential. The implementation of this proposed solution requires a multidisciplinary approach and the integration of expertise in the fields of nanotechnologies, biotechnologies, communication technologies and neuroscience.

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THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (CDDR/ULSOP), www.pharmacy.ac.uk , (UK) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPG), www.mpg.de , (DE) RESEARCH AND DEVELOPMENT OF CARBON NANOTUBES S.A. (NTX), www.nanothinx.com , (EL) SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA (SSSA-CRIM), , (IT) THALES SA (TRT-FR), www.thalesgroup.com , (FR)

NOMS • • •

Acronym: NOMS Project Title: NANO-OPTICAL MECHANICAL SYSTEMS Participants:



Project Abstract: Nano-optical mechanical actuation based on nanotube-enriched polymeric materials is a much sought-after technology. In this scheme, light sources promote mechanical actuation of the polymeric materials producing a variety of nano–optical mechanical systems such as tactile displays, artificial muscles, and nanogrippers among others. The purpose of the NOMS project is to fabricate microsystems capable of light-induced mechanical actuation. In particular, the team proposes to build a visual-aid tablet for the blind or partially-sighted. Accomplishing this ambitious project requires knowledge of basic and integrating research within the field. It also requires the contribution of expert neuropsychologists to study, in cooperation with end-users, the effectiveness of the tablet both as an assistive tool for the visually impaired and as a research tool in the field of neuropsychology. The consortium is formed by experts in the areas of materials, optics, microsystems, neuropsychology, as well as end users, who will fabricate the first visual aid tablet. This well-balanced team possesses a unique combination of talent to guarantee achievement of the project objectives. The NOMS approach ensures that a solution (photo-actuated nanomaterials) will be provided to a particular problem (fastrefreshed portable visual-aid devices). NOMS will provide tactile screens for the visually impaired to read complex visual representations such as mathematical equations and graphical images. Everyday activities of such individuals will be greatly improved by including these devices in ATMs, personal computers, mobile telephones etc. This project is visionary with respect to some of the mainstream R&D directions, offering European industry a competitive advantage in the assistive technology marketplace worldwide. Appropriate industrial partnerships with adequate technology transfer experience have been included in the consortium with the purpose of thorough exploitation of the technology.

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AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC-CNM), http://www.csic.es , (ES) IXSCIENT LIMITED (iXscient), , (UK) MICROSHARP CORPORATION LIMITED (Microsharp), , (UK) PHILIPS ELECTRONICS NEDERLAND B.V. (Philips), www.philips.com , (NL) USTAV POLYMEROV - SLOVENSKA AKADEMIA VIED (PISAS), www.polymer.sav.sk , (SK) UNIVERSITAT AUTONOMA DE BARCELONA (UAB), http://www.uab.es , (ES) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE (UCAM), www.cam.ac.uk , (UK) UNIVERSITAET HAMBURG (UHamburg), http://www.uni-hamburg.de/ , (DE) Unia nevidiacich a slabozrakych Slovenska (UNSS), http:\\unss.sk , (SK)

NUCAN • • •

Acronym: NUCAN Project Title: Nucleic Acid Based Nanostructures Participants: – – – –

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ALPHACONTEC CONSULTING SERVICES GMBH (ALPH), www.alphacontec.de , (DE) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) KAROLINSKA INSTITUTET (CRC-KI), www.ki.se , (SE) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER), www.fraunhofer.de , (DE) INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V (IPHT), www.ipht-jena.de , (DE) NANOTEC ELECTRONICA SL (NANOTEC), http://www.nanotec.es , (ES) KøBENHAVNS UNIVERSITET (UKBH), www.ku.dk , (DK) UNIVERSITY OF NEWCASTLE UPON TYNE (UNEW), www.newcastle.ac.uk , (UK) ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA (UNIBO), www.unibo.it , (IT) TECHNISCHE UNIVERSITAET DORTMUND (UNIDO), www.tu-dortmund.de , (DE)

Project Abstract: The aim of the proposal is to develop a nanoscale toolbox to create smart materials based on the use of natural and artificial nucleic acids. Nanometer sized particles and single (bio)molecules will be connected with restricted and well defined placing to each other and to surfaces. Focus of the proposed STREP is to develop basic building blocks that are capable to arrange by self organisation facilitated by molecular recognition. Complexes generated by nucleic acid directed assembly may be non-periodic and non-regular to combine complex features. Examples of application of such material are incorporated in the project, to direct the development and show the potential of the long term-innovation introduced by NUCAN. Fields of application are bioanalytics, pharmaceutical receptor screening and nanoelectronics. Besides the information content and their dominant role in all life sciences, esp. genetics, nucleic acids have unique properties as polymers and as macromolecules. Both the addressability of each unique site within a given sequence on a nucleic acid strand by base recognition as well as the chemical homogeneity of the polymer through the repeating unit of the backbone makes nucleic acids ideal molecules for the construction of highly ordered but non-periodic supramolecular entities. The aim of the proposal is to develop nanometer scale constructs made of nucleic acids in one, two and three dimensions. Basic principles and development of enabling technologies, detection and production processes are in the focus of the proposal to prepare a basis for applications of nucleic acid based nanoconstructs.

OBSERVATORYNANO • • •



Acronym: OBSERVATORYNANO Project Title: European observatory for science-based and economic expert analysis of nanotechnologies, cognizant of barriers and risks, to engage with relevant stakeholders regarding benefits and opportunities. Participants: – – – – – – – – – – – – – – – –

ASSOCIAZIONE ITALIANA PER LA RICERCA INDUSTRIALE - AIRI (AIRI), www.airi.it , (IT) AARHUS UNIVERSITET (AU), www.au.dk , (DK) BAX & WILLEMS (B&W), www.bwcv.es , (ES) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT (EMPA), www.empa.ch , (CH) INSTITUTE OF OCCUPATIONAL MEDICINE (IOM), www.iom-world.org , (UK) INSTITUTE OF NANOTECHNOLOGY (ION), www.nano.org.uk , (UK) UNIVERSITEIT MAASTRICHT (MERIT, University of Maastricht), http://www.maastrichtuniversity.nl , (NL) MALSCH TECHNOVALUATION (MTV), www.malsch.demon.nl , (NL) NMTC (NANO & MICRO TECHNOLOGYCONSULTING) - DR MATTHIAS WERNER (NMTC), www.nmtc.de , (DE) RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (RIVM), www.rivm.nl , (NL) SPINVERSE OY (Spinverse), www.spinverse.com , (FI) TECHNOLOGICKE CENTRUM AKADEMIE VED CESKE REPUBLIKY (TCASCR), www.tc.cz , (CZ) TRIPLE INNOVA (triple innova), www.triple-innova.com , (DE) TECHNISCHE UNIVERSITAET DARMSTADT (TUD), www.tu-darmstadt.de , (DE) VDI TECHNOLOGIEZENTRUM GMBH (VDI TZ), www.vditz.de , (DE)

Project Abstract: observatoryNANO brings together leading EU organizations who collectively have expertise in the technological; economic; societal/ethical; health, safety, and environmental analysis of nanotechnologies. Its primary aim is to develop appropriate methodologies to link scientific and technological development of nanotechnologies with socio-economic impacts. Both of these aspects will be enhanced by expert opinion, making this project unique in providing relevant web-based reports in a common format across all sectors, considered by all criteria, and widely publicized. observatoryNANO will become an industry leading and opinion forming catalyst for nanotechnology in the EU. The purpose is to avoid the exaggerated socio-economic impact of nanotechnologies and place developments in a realistic time-frame. It will present a reliable, complete, and responsible science-based and economic expert analysis of peer-reviewed literature, patents, national funding strategies, investment trends, and markets; in combination with information derived from questionnaires, interviews and workshops with academic and industry leaders, investors, and other key stakeholders. It will place these developments in the context of potential ethical and societal issues, and risks to human health and the environment, through its own analysis and through engagement with other actors, to ensure that its recommendations are balanced and contribute to the safe and responsible development of nanotechnologies. It will collaborate with all appropriate organizations including the EPO, OECD, industry associations, ETPs, and other EU-funded projects. Through these activities observatoryNANO will form a balanced governing board of key EU stakeholders. It will react to advice and input from these stakeholders, and advise on potential opportunities, barriers, and risks. This will allow decision-makers to take appropriate action to ensure that nanotechnology developments are realized as socio-economic benefits.

PANOPTES • • •

Acronym: PANOPTES Project Title: Peptide-based Nanoparticles as Ocular Drug Delivery Vehicles Participants:



Project Abstract: This project will develop methodology for the manufacture of novel peptide-based nanoparticles and nanocapsules to satisfy an unmet clinical need: sustained drug delivery to the posterior segment of the eye. The proposed consortium brings together internationally leading groups in self-assembling polypeptide nanoparticle and nanocapsule preparation by chemical (Durham) and genetic (Nijmegen) approaches, drug loading and in vitro release studies (Helsinki & Madrid), in vitro and in vivo assessment of nanoparticle biocompatibility and functionality (Helsinki, Madrid & Tübingen) and polymer synthesis, processing and industrial validation of manufacturing processes (DSM). Polyester micro- and nanoparticles that have been proposed for ocular drug delivery have several major drawbacks: acidic degradation products cause inflammation; drug release is difficult to control; and peptides and proteins are difficult to encapsulate. A platform of novel, peptide-based nanomaterials, formed through bio-inspired self-assembly processes, will be developed to overcome these problems. Peptide-based materials have a number of attractive features: biodegradation gives non-inflammatory products; self-assembly occurs under mild conditions; they possess a rich chemical diversity; they are defined at the sequence level. Polypeptides and peptide hybrid materials will be processed into nanoparticles, polymeric vesicles (polymersomes) and nanocapsules. These biodegradable and biocompatible materials will be used as containers for the loading, controlled release and cellular delivery of therapeutic molecules. The consortium therefore will enable the industrial manufacture of as-yet unobtainable, high value nanotechnology-based products utilising intrinisically low-energy demand nanobiotechnological phenomena. These will produce a step change improvement in the quality of products for sustained drug delivery to the posterior segment of the eye, enhancing the competitiveness of European industry.

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DSM RESEARCH B.V. (DSM), www.dsm.com , (NL) STICHTING KATHOLIEKE UNIVERSITEIT (RUN), www.ru.nl , (NL) COMPLUTENSE DE MADRID (UCM), , (ES) UNIVERSITY OF DURHAM (UDUR), , (UK) HELSINGIN YLIOPISTO (UH), http://www.helsinki.fi/university/ , (FI) EBERHARD KARLS UNIVERSITAET TUEBINGEN (UT), www.uni-tuebingen.de , (DE)

PARNASS • • •

Acronym: PARNASS Project Title: Parallel nano assembling directed by short-range field forces Participants: –

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FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FRAUNHOFER IFF), www.fraunhofer.de , (DE) HOGSKOLAN I HALMSTAD HH (HH), www.hh.se , (SE) LUNDS UNIVERSITET (LU), www.lu.se , (SE) RAITH GMBH (RAITH), www.raith.de , (DE) UNIVERSITAET LEIPZIG (UL), http://www.uni-leipzig.de , (DE) UNIVERSITAT ROVIRA I VIRGILI (URV), http://www.urv.cat , (ES)

Project Abstract: Parallel nanoassembling directed by short-range field forces (PARNASS) is a radical innovative approach for fabricating large volumes of hybrid nanoelectronic devices. This method addresses the challenging physical and engineering problem of very high accuracy over a large area. We think that use of specially designed nanoscale force fields is the only realistic method for large-scale nanomanufacturing. As a primary need we identify research towards a detailed understanding of these forces and development of a technology for parallel short-range forces directed nanoassembling. For that, a deep knowledge of the forces acting between nanoparticles and substrate is necessary. Theoretical and experimental works within this project are directed to get a detailed qualitative and quantitative understanding of the forces. Objectives of the project are: to develop phenomenological understanding of the forces between nanoparticles and the substrate and between nanoparticles themselves; to determine geometry and material of nanostructures which are optimal for nanoparticles trapping and aligning; to define practically allowable nanopositioner design and fabrication technologies; to develop and construct an automated analyser for nanostructured surfaces investigation; to develop and construct a proof-of-concept technology demonstrator including an appropriate hybrid device prototype. We consider a nanoelectronic sensory device with particular carbon nanotubes as an example to demonstrate the proposed nanoassembling technology. Most aspects of this project fall within IST-NMP-3, addressed at the frontier of knowledge aiming at radical innovation in the long term and benefiting of nanotechnology interdisciplinary work. Moreover, it has broader perspective due to its relevance to basic knowledge. Its results will have impact on other thematic priorities like new analytical devices for data acquisition for healthcare, so some project aspects fall within IST-NMP-2.

PARYLENS • • •

Acronym: PARYLENS Project Title: PARYLENE based artificial smart LENSes fabricated using a novel solid-on-liquid deposition process Participants:



Project Abstract: The main goal of the project PARYLENS is to develop the next generation optical devices, based on an innovative and reliable concept inspired by natural optical systems such as the human and the fly eyes. We propose the following devices to the European citizen and industry: 1) tuneable lenses 2) truly accommodative intraocular lenses 3) bistable flexible displays The development of those devices relies on recent advances in nanotechnology combined with the patented SOLID (Solid On Liquid deposition) process, which offers the possibility to grow a stable solid layer directly onto a liquid, such that the solid uniformly replicates and encapsulates the liquid template. When using the polymer Parylene as solid layer, the resulting interface is perfectly smooth and the liquid template remains unaffected, which is ideal for optical applications. Parylene is stable, biocompatible, highly transparent, and can be deposited in a one-step process also on liquids. PARYLENS proposes to develop low cost yet high quality, reliable smart devices. The actuation of the tuneable lenses will rely on Parylene-based electroactive polymers and liquid crystals. Tuneable lenses are expected to have an impact on the consumer electronics market (mobile phones, cameras, etc) in addition, the development of low actuation voltages tuneable lenses will profit to the biomedical devices market (artificial eyes, endoscopes, etc). The truly accommodative intraocular lenses will closely mimic the structure and shape of the crystalline lens of the human eye. They will also prevent inflammation and infections. The structure of microlens arrays will be used to develop flexible bistable liquid crystals displays. The consortium is well balanced (12 partners from 8 countries) and goes for full complementarity. It comprises 4 SMEs, 3 universities and 4 research centres. Together they will make this ambitious multidisciplinary project a reality.

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To be confirmed (AJL), , (ES) BAR ILAN UNIVERSITY (BIU), www.biu.ac.il , (IL) CEDRAT TECHNOLOGIES SA (CEDRAT), www.cedrat.com , (FR) FUNDACION CIDETEC (CIDETEC), www.cidetec.es , (ES) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR-ISMAC), www.cnr.it , (IT) To be confirmed (COMELEC), , (CH) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (FhG-PYCO), www.fraunhofer.de , (DE) POLITECHNIKA GDANSKA. (GUT), www.pg.gda.pl , (PL) HAUTE ECOLE SPECIALISEE DE SUISSE OCCIDENTALE (HES-SO), www.hes-so.ch , (CH) INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW (IMEC), www.imec.be , (BE) SCIPROM SARL (SCIPROM), http://www.sciprom.ch , (CH) To be confirmed (VARIOPTIC), , (FR)

PECTICOAT • • •

Acronym: PECTICOAT Project Title: Nanobiotechnology for the coating of medical devices Participants:



Project Abstract: Surfaces of medical materials and devices that come into direct contact with human tissues need to be fine-tuned with regard to both physical and biological properties. A cross-disciplinary nanotechnology approach is proposed that aims to impart material surfaces with appropriate biological properties. This approach gathers competences from across Europe and includes a critical mass of resources necessary to accelerate the R&D process. The biomolecules that are to be grafted onto surfaces to function as nanocoatings have been selected from a class of complex polysaccharides, the pectic rhamnogalacturonans, that are known to possess anti-inflammatory properties as well as desirable physical properties. Sugar molecular structure will be altered in a controlled manner so as to favourably influence living cell behaviour around the coated materials. Current knowledge and expertise within our project team covers technologies to manufacture a range of tailored polysaccharides, to attach the molecules covalently to relevant biomaterials (e.g. titanium for dental implants) and to characterize the grafted surfaces and to assess their biocompatibility both in vitro and in vivo. We expect to generate evidence demonstrating both the antiinflammatory and molecular flexibility of the innovative nanocoatings. This will open a platform for the development of a large range of applications that will be defined through industrial guidance and result in solutions for current bioincompatibility problems of various implantable devices. Industrial monitoring and engineering will allow the exploration of a wide range of applications (breast implants, meshes etc.). For one of these: the dental application, the involvement of industrial SMEs covers the full production chain from raw material to prototype design which will lead in to a demonstration phase.

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NOBIL BIO RICERCHE SRL (12 NBR), , (IT) AGLIATI SRL (AGLIATI), www.agliati.it , (IT) AARHUS UNIVERSITET (AU), www.au.dk , (DK) DANMARKS JORDBRUGSFORSKNING (DIAS), www.agrsci.dk , (DK) UTEAM SA (DIVERGENT), www.divergent.fr , (FR) JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (JRC), http://www.jrc.ec.europa.eu , (BE) POALIS AS (POALIS), www.poalis.dk , (DK) STATICE SANTE SA (STS), www.statice.com , (FR) UNIVERSITA DEGLI STUDI DI TRENTO (UNITN), www.unitn.it , (IT) UNIVERSITY OF LEEDS (UNIVLEEDS), www.leeds.ac.uk , (UK) OULUN YLIOPISTO (UOULU), www.oulu.fi , (FI) UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE (UTC-UMR6600), www.utc.fr , (FR) WAGENINGEN UNIVERSITEIT (WU), http://www.wageningenuniversiteit.nl/UK/ , (NL)

PHOTONANOTECH • •

Acronym: PHOTONANOTECH Project Title: Photozyme Nanoparticle Applications for Water Purification, Textile Finishing, Photodynamic Biomineralization and Biomaterial Coating



Participants: – – – – – – – – – – – –

E DO MINHO (3B'S-UM), www.uminho.pt , (PT) COLOR CENTER SA (COL), www.colorcenter.es , (ES) INOTEX SPOL SRO (INO), www.inotex.cz , (CZ) PERCA LTD (PER), www.perca-bg.com , (BG) CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS-CIEMAT (PSA), http://www.ciemat.es , (ES) POLITECNICO DI TORINO (PTO), www.polito.it , (IT) SPECIAL POLYMERS LTD (SPO), www.kanokonlitglues.com , (BG) SOFIISKI UNIVERSITET SVETI KLIMENT OHRIDSKI (SUN), www.uni-sofia.bg , (BG) TECNOLOGIE BIOMEDICHE SRL (TBS), www.tecnologiebiomediche.com , (IT) TINFER SL (TIN), www.tinfer.com , (ES) INSTITUT FUER VERBUNDWERKSTOFFE GMBH (UKL), http://www.ivw.uni-kl.de , (DE) UNIVERSITAT POLITECNICA DE CATALUNYA (UPC), www.upc.edu , (ES)

PHOTONANOTECH cont. •

Project Abstract: The photozymes (P) are amphiphilic water-soluble copolymers consisting of hydrophobic chromophoric and hydrophilic monomer units forming nanosized pseudo-micelles which hydrophobic core allows to transfer the solar energy into chemical energy due to the antenna effect (AE) with singlet oxygen production (SOP) and the tailored photochemical transformation of the solubilized in the hydrophobic pocket molecules. The co-existence of these two distinctive for the photosynthesis effects in P opens wide range of possible technological innovation developments. The goal of PhotoNanoTech (PNT) is to develop new nano-based processes with long-term applications in the wastewater decontamination (WD), textile processing, biomedical coating and materials development, as well as for bone regeneration. New P will be synthesized to this goal, using zwitterionic (ZI) monomers providing them specific antipolyelectrolyte properties, salt-philicity as well as an unique self-organization ability (SOA), similar to that of phospholipids (PL). AE-induced chemical reactions of the solubilized hydrophobic compounds is the fundament of P applications for the photocatalytic WD. pH-independent photocatalytic WD from dissolved hydrophobic compounds and damaging inorganic salts are the advantages of the suggested ZI P. The combination of AE and SOP could find a new and promising application for making self-cleaning textiles. PL vesicles are the place for the calcium phosphate nuclei formation and grow. PNT will exploit SOA of ZI P for their participation in the biomineralization (BZ) process. Photosensitizing characteristics of ZI P included in such vesicles opens the opportunity for light-controllable BZ, called photodynamic BZ. A valuable property of ZI-based materials is their biocompatibility. PNT includes the production of such materials (by photoinduced graft-copolymerization) with suppressed inflammatory response, enhanced biolubrication characteristics and haemocompatibility.

PLASMANICE • • •

Acronym: PLASMANICE Project Title: Atmospheric Plasmas for Nanoscale Industrial Surface Processing Participants: – – –

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AFS ENTWICKLUNGS + VERTRIEBS GMBH (AFS), , (DE) DANMARKS TEKNISKE UNIVERSITET (DTU), www.dtu.dk , (DK) FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (Fh-ISC), www.fraunhofer.de , (DE) INSTITUT JOZEF STEFAN (JSI), www.ijs.si , (SI) Print 2000 Nyomda Kft. (PNK), www.print2000.hu , (HU) SAPPI NETHERLANDS SERVICES B.V. (Sappi), , (NL) SEGERS & BALCAEN NV (SB), www.segers-balcaen.com , (BE) STORA ENSO OYJ (SE), , (FI) SurA Chemicals GmbH (SurA), www.surachemicals.de , (DE) TECHNISCHE UNIVERSITEIT EINDHOVEN (TUE), w3.tue.nl , (NL) TTY-SAATIO (TUT), www.tut.fi , (FI) VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V. (VITO), www.vito.be , (BE) VALTION TEKNILLINEN TUTKIMUSKESKUS (VTT), www.vtt.fi , (FI)

Project Abstract: Atmospheric plasma techniques as processing methods have a number of advantages which include their ability to tailor the surface chemistry at the nanometre level. As such, the plasma treatments are energy efficient, reproducible and environmentally clean. In-line, continuous reel-to-reel processing equipment has been developed in the last 5 years. The wide scale application of this nanoprocessing technology in the pre-treatment of packaging materials in reel-to-reel processing has however been severely limited. One of the main reasons for this is the relatively slow processing velocity for coating depositions. In general, the velocities need to be increased by 2-5 fold in order to fully exploit the new nano-processing techniques. This proposal will address these issues in order to assist in the transfer of atmospheric plasma processing technology from the laboratory scale to industrial level in the packaging industry. Special attention will go out to the very promising combination with sol-gel technology. A method and equipment for in-line plasma deposition of high-barrier bio-based coatings to be applied in conjunction with extrusion coating at industrial line speeds will be developed. The approach will exploit solgel coatings applied on the substrates by plasma deposition. The substrates include paper, cardboard and plastic films. Renewable, biobased and biodegradable materials will be used as extrusion coatings. The project aims at replacement of fluoropolymer based grease barrier materials with sol-gel coated bioplastics and substitution of non-renewable barrier packaging films with renewables based materials in general. To achive these objectives, several leading European institutes and universities in atmospheric plasma deposition technology (VITO and TUE), sol-gel development (FhG-ISC and VTT) and extrusion coating and analytics development (TUT and JSI) together with a range of industrial participants are incorporated in the proposal.

PROFORM • • •



Acronym: PROFORM Project Title: Transforming nano-particles into sustainable consumer products through advanced product and process formulation Participants: – – – – – – – – – –

UNIVERSITAET KARLSRUHE (TECHNISCHE HOCHSCHULE) (UNIKARL), www.uni-karlruhe.de; www.kit.edu , (DE) BAYER TECHNOLOGY SERVICES GMBH (BAYER), www.bayertechnology.com , (DE) BHR GROUP LIMITED (BHR), www.bhrgroup.com , (UK) C3M DOO, CENTER ZA RACUNALNISTVO VMEHANIKI KONTINUUMA - MODELIRANJE IN TRZENJE (C3M), www.c3m.si , (SI) POZNAN UNIVERSITY OF TECHNOLOGY (PUT), www.put.poznan.pl , (PL) ROCKFIELD SOFTWARE LIMITED (ROCKFIELD), www.rockfield.co.uk , (UK) THE UNIVERSITY OF BIRMINGHAM (UBHAM), www.bham.ac.uk , (UK) LOUGHBOROUGH UNIVERSITY (UL-B), www.lboro.ac.uk , (UK) UNILEVER UK CENTRAL RESOURCES LIMITED (UNILEVER), www.unilever.com , (UK) POLITECHNIKA WARSZAWSKA (WUT), http://www.pw.edu.pl , (PL)

Project Abstract: The key to delivering sustainable nano-based products is to achieve breakthroughs in our understanding of the chemical and physical behaviour of nano-particles and their interactions with each other and the surrounding environment. This can be achieved by ensuring that the nano-particles are incorporated into products in a fully dispersed and stable state such that the nano-properties of interest are retained. The objective of the project is therefore: To develop the next generation of process tools and methodologies for the design and production of products containing nano-particles in a highly dispersed, functional and stable state. This will require the development of fundamental understanding of phenomena related to the processing of nano-particles including micro-, meso and macroscale hydrodynamics, colloidal stability and manipulations of the particle size distribution and medium composition in order to improve physical properties of dispersed nano-particle products and to reduce waste for economic and environmental savings. In order to meet this objective the project will need to: 1. Improve our understanding of the formulation technology for a range of nano-particles, including identifying the mechanisms of the incorporation, dispersion and stabilisation of nano-particles in a liquid medium 2. Develop more targeted methods for the preparation and production of ultra-fine suspension of nano-particles. 3. Develop new process design tools and methods for processing nano-particles such that they retain their key features for minimum processing.

PRONANO • • •

Acronym: PRONANO Project Title: Promoting Technology Transfer of Nanosciences, Nanotechnologies, Materials and new Technologies Participants: –

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Production

FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V (Fraunhofer), www.fraunhofer.de , (DE) GLE Growth Capital Limited (GLE GC), , (UK) I.CON. INNOVATION GMBH (ICON), www.icon-innovation.de , (DE) ICONS S.R.L. (ICONS), http://www.icons.it , (IT) MERMAID VENTURE APS-INVESTORNET GATE2GROWTH DK GATE2FINANCING DK BRABO VENTURES DENMARK (Mermaid), www.gate2growth.com , (DK) ORION INNOVATIONS LLP (ORION), www.orioninnovations.co.uk , (UK) Sociedad de Desarrollo de Navarra, S.A. (Sodena), www.sodena.com , (ES) TECHNOFI SA (TECHNOFI), www.symple.eu , (FR) TECHNOSTART BERATUNGSGESELLSCHAFT FUER BETEILIGUNGSFONDS MBH (TECHNOSTART), www.technostart.com , (DE) ZABALA INNOVATION CONSULTING, S.A. (ZABALA), www.zabala.es , (ES)

Project Abstract: ProNano aims at validating new practices to remove the major barriers that prevent results out of scientific research projects on nanotechnology field from reaching market applications: market barriers, technology barriers, financial barriers, managerial barriers. Managed by experienced innovation consultant firms and venture capitalist from several European countries, and involving European and national nanotechnology networks and platforms, ProNano promotes existing results of scientific research projects available in EU research centres that have not yet been exploited, through assistance to the entrepreneurial teams connected to such research work. First, existing research results are identified and screened for evaluation of their commercial potential. The technical information is completed by a business-relevant analysis of technological competitive markets, road maps to financing, and management issues leading to draft business plans. Then, potential entrepreneurs and investors are associated to this process and coached by technology transfer and innovation professionals including specialists in venture capital/ private equity financing and banking instruments. The promising nanotechnologies are made ready to be licensed for sale to industry or developed into business proposals for start-up companies. ProNano ultimately aims at closing investment deals to prove the approach successful (completing full financing rounds to venture capital investors/established businesses, or licensing agreements). Lessons learnt during the project and policy recommendations are presented to the broad public at a final event.

PSY-NANO-SI • • •

Acronym: PSY-NANO-SI Project Title: NANOSILICON-BASED PHOTOSYNTHESIS FOR CHEMICAL AND BIOMEDICAL APPLICATIONS Participants: – – – – –



KATHOLIEKE UNIVERSITEIT LEUVEN (CUL), www.kuleuven.be , (BE) KOBE UNIVERSITY (KU), www.kobe-u.ac.jp , (JP) M V LOMONOSOV MOSCOW STATE UNIVERSITY (MSU), www.msu.ru , (RU) POLITECNICA DE VALENCIA (MTM-UPV), www.upv.es , (ES) TECHNISCHE UNIVERSITAET MUENCHEN (TUM), www.tu-muenchen.de , (DE)

Project Abstract: The project joins together two most common and apparently well-studied elements on the Earth - silicon and oxygen. Both are most important for human life: oxygen mediates biochemical reactions while silicon is the most important technological material. The project claims to explore a new type of interaction among these elements, though in their artificially created forms (silicon converted into nano-Si - with small Si clusters connected into highly porous network, and oxygen excited into highly reactive singlet state). Project will address fundamental issues of physics (optics of nano-structured semiconductors, energy transfer between molecules), chemistry (photo-chemical reactions mediated by singlet oxygen with molecules, e lectrochemistry of porous semiconductors, surface reactions), biology (photo-oxidation of bio-molecules) and medicine ( photostimulated apoptosis of living cells). Therefore, it will contribute to the advancement in these fields of science and will ensure continuous break-through innovations in important issues of human well-being. Technological frontiers to explore are application of highly reactive singlet form of oxygen molecule generated by nano-Si in a variety of fields vital for the improvement of human life: curing of severe diseases, fine organic synthesis, protection of environment. Specific Scientific and Technological Objectives of the project include: 1.Research and development of new process of singlet oxygen generation employing nano-Si as sensitizer; 2 Development of efficient and safe photo-sensitizers based on nano-Si; 3. Exploration of the possibilities to use nano-Si photo-sensitizers in Photo-dynamic therapy of cancer; 4. Application of nano-Si photo-sensitizers in organic synthesis and Biological applications Project explores two fundamental discoveries made by consortium members: generation of singlete oxygen by nano-Si and its biodegradabilit

QUORUM • • •



Acronym: QUORUM Project Title: Discovering Quorum Sensing in industrially useful Fungi, a novel approach at molecular level for scaling-up in white biotech. Participants: – – – – – – – –

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS/CBRL), www.cnrs.fr , (FR) UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II. (DCOB), www.unina.it , (IT) VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE (ICTP), www.vscht.cz , (CZ) PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS (PECS), www.pte.hu , (HU) TURUN YLIOPISTO (U. TURKU), , (FI) UNIVERSITE CATHOLIQUE DE LOUVAIN (UCL), www.uclouvain.be , (BE) THE UNIVERSITY OF WESTMINSTER (UOW), , (UK) WETLANDS ENGINEERING SPRL* (WET), www.wetlands.be , (BE)

Project Abstract: Fungi have proved to be a source of bioactive natural products and industrially important target products such as (i). Enzymes, (ii). Bioplastics, (iii). Bio-dyes, (iv). Vitamins, (v)? The overall aim of this proposal is to use nanotechnology using natural molecules involved in fungal cell communications and mini-scale process parameters, to maintain and improve productivity for the white biotech industry of the commercially important bioproduct, and particularly laccases. The specific objectives of this proposal are: Using a Quorum Sensing approach at nano-scale for better understanding of biosynthesis of the industrially important target products; Quorum sensing and signal transduction in relation to fungal physiology and morphology in agitated systems; Comparative analyses of fungal cell communication in small and large scale submerged fermentations; The relevance and interrelation of traditional scale-up factors to quorum sensing in fungal cultures. The QUORUM project is based on a multidisciplinary approach, and builds a dynamic relation between 8 partners (1 SME and 7 Universities and Research Centres) from 7 countries. The QUORUM project will enhance competitiveness and sustainability of European industries by the development of leading-edge advances in environmentally respectful, energy efficiency, resource efficient processes and product technology. Two main technology innovation areas are concerned: enzymes and fine chemical productions. The QUORUM project will lead to a positive impact on economy through new/increased added value products, a beneficial impact on environmental issues, and new production models based on knowledge to replace trial error will be proposed to the industrial biotechnology sector in the value chain. The QUORUM project will support the Action Plan for environmental technology (COM 131-2003) as well as the ?Life sciences and biotechnology: a strategy for Europe (COM 27-2002).

REALISE • • •

Acronym: REALISE Project Title: Rare Earth Oxide Atomic Layer Deposition for Innovation in Electronics Participants:



Project Abstract: The REALISE project aims (i) to develop an atomically controlled deposition process for high-k oxide layers as an enabling technology for a variety of innovative integrated circuit technologies and (ii) to advance fundamental knowledge of materials functionality in the areas of thin film growth, oxide-semiconductor interfaces, surface-precursor reactions and atomic-scale characterisation of dielectrics. These two global aims will be achieved by collaborative research across a range of disciplines. No satisfactory process exists for depositing rare earth oxide films as high-k dielectrics at present. The process that is the subject of this project is atomic layer deposition (ALD), the leading technology for deposition of nanometre-scale films. The project aims to overcome the current difficulties and limitations of rare earth oxide ALD, through project goals that span the entire process: design, synthesis, scale-up and testing of suitable precursors; characterisation of film quality and optimisation of deposition parameters. To investigate the functionality of rare earth oxides as dielectrics and to show the utility of ALD in the electronics industry, further goals of REALISE are: deposition onto variously-prepared semiconductor substrates (Si, Ge); high-resolution characterisation of the semiconductor-oxide interface; scale-up of new ALD process to industrially-sized Si wafers; testing of dielectric in capacitors for innovative memory (DRAM, NVM) and wireless (decoupling for RF) applications. REALISE thus brings together unique expertise to achieve urgently-needed materials integration solutions for the European semiconductor industry.

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ASM MICROCHEMISTRY OY (ASMM), www.asm.com , (FI) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) SAFC HITECH LIMITED (EPC), www.safchitech.com , (UK) QIMONDA DRESDEN GMBH & CO.OHG (INFINEON), , (DE) NXP SEMICONDUCTORS NETHERLANDS BV (NXP), www.nxp.com , (NL) PHILIPS ELECTRONICS NEDERLAND B.V. (PHILIPS), www.philips.com , (NL) STMICROELECTRONICS SRL (ST ITALY), www.st.com , (IT) NUMONYX ITALY S.R.L. (ST M6 SRL), , (IT) UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK (TYNDALL-UCC), www.ucc.ie , (IE) HELSINGIN YLIOPISTO (UHEL), http://www.helsinki.fi/university/ , (FI) THE UNIVERSITY OF LIVERPOOL (UNIVLIV), www.liverpool.ac.uk , (UK)

RECEPTRONICS • • •



Acronym: RECEPTRONICS Project Title: Label Free Biomolecular Detectors: at the Convergence of Bioengineered Receptors and Microelectronics Participants: – – – – – – –

ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA (ARCES), www.unibo.it , (IT) COMMISSARIAT A L' ENERGIE ATOMIQUE (CEA), www.cea.fr , (FR) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), www.cnrs.fr , (FR) NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS (NKUA), www.elke.uoa.gr , (EL) SILICON BIOSYSTEMS SPA* (SIBIO), www.siliconbiosystems.com , (IT) SOCIETE DE PHARMACOLOGIE ET D'IMMUNOLOGIE BIO SAS (SPI-BIO), www.spibio.com , (FR) UNIVERSITY OF SOUTHAMPTON (UNISO), http://www.southampton.ac.uk , (UK)

Project Abstract: The goal of this project is to develop low-cost, label-free biomolecular detectors/sentinels by integrating concepts and methods from bionanotechnology and microelectronics. More specifically, the project aims to design, fabricate, test and validate a biomorphic hybrid technology by which biological self-assembling structures are interfaced with advanced electronic circuits for signal detection, amplification and conditioning. So doing, we exploit the strength of biotechnology to achieve a very high sensitivity and selectivity, as well as the great potential of micro- and nano-electronics to address system miniaturization, low-power consumption, and low cost. The approach is based on arrays of independent and electrically addressable micro-spots where functional lipid bilayers are self-assembled either in structured micron- scale apertures, or in artificial nanometric pores. Membrane functionalization is determined by embedding bioengineered ion channels or receptors in the lipid bilayers, to achieve highly specific interactions with target molecules. The array is organized so as to couple each spot with a smart and miniaturized electronic interface for the detection, amplification and conditioning of the signals produced by the transmembrane ion fluxes induced by the target molecules. An additional goal of this approach is to boost the overall system performance by means of advanced data processing and storage architectures. An important objective of the proposal will be the evaluation and the assessment of the technology as a valuable platform in health applications with respect to state of the art counterparts. For this purpose, validation exercises will be undertaken within the program, using different kinds of receptors for several applications.

RESOLVE • •

Acronym: RESOLVE Project Title: Bottom-up Resolution of Functional Enantiomers from Self-Organised Monolayers



Participants: – – – – – –



AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) KATHOLIEKE UNIVERSITEIT LEUVEN (K.U. Leuven), www.kuleuven.be , (BE) SYNCOM BV (SYNCOM), www.syncom.nl , (NL) TECHNISCHE UNIVERSITEIT EINDHOVEN (TUE), w3.tue.nl , (NL) UNIVERSITE DE MONS (UMH), www.umons.ac.be , (BE) THE UNIVERSITY OF LIVERPOOL (UoL), www.liverpool.ac.uk , (UK)

Project Abstract: The high throughput identification of resolution systems for industrially important chiral chemicals will be approached using the bottom-up hierarchichal assembly from self-organised chirally nanostructured surfaces and the “Dutch resolution” family method to isolation of enantiomers. Molecular modelling, surface science, supramolecular chemistry and the critically important resolving library design will be used in synergy to develop systems which separate enantiomers and which can be patterned and miniaturised. The preparation of chiral surfaces and the knowledge of chiral discrimination phenomena at the nanoscale will be exploited to use them to template the formation of diastereomers, which in turn will lead to the formation of crystals (whose composition will be determined) containing pure enantiomers. The project’s end goal is a rapid method for the identification of resolving systems for optically active compounds, and would constitute a leap forward for the area.

S3 • • •



Acronym: S3 Project Title: Surface ionization and novel concepts in nano-MOX gas sensors with increased Selectivity, Sensitivity and Stability for detection of low concentrations of toxic and explosive agents. Participants: – – – – –

CONSIGLIO NAZIONALE DELLE RICERCHE (CNR-INFM), www.cnr.it , (IT) EADS DEUTSCHLAND GMBH (EADS), www.eads.net , (DE) EBERHARD KARLS UNIVERSITAET TUEBINGEN (EKUT), www.uni-tuebingen.de , (DE) FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'ENERGIA DE CATALUNYA (IREC), www.irec.cat , (ES) UNIVERSITAET ZU KOELN (UNIKO), www.uni-koeln.de , (DE)

Project Abstract: The objective of S3 is developing breakthrough technologies in gas sensing that will provide higher sensitivity and selectivity at reduced cost. This objective will be pursued by bringing together excellence and complementary skills of ropean Union and Russian groups. Enhanced sensitivity and selectivity will enable toxic and explosive gases to be detected against a background of air constituents and ubiquitous air contaminants. This task will be pursued by studying sensors and sensing principles based on semiconductor nanowires (NWs) molecularly engineered, in terms of doping level, the used additives and /or functionalization processes and heterostructures and deposited onto SiO2/Si and/or alumina MEMS heater platforms. These platforms will be configured in innovative ways to obtain multiple signals from one and the same sensitive layer. Signals recovered will include resistive, field-effect, ion emission and catalytic/thermal conductivity response of the NW materials. Low power operation and additional enhancements in selectivity will be obtained through pulsed-temperature operation and combined self-heated operation mode using dynamic and steady state responses and modulated optical excitation. Furthermore, the increased stability of NW-based sensing materials will positively affect the reliability of the developed sensors. In order to meet application demands, S3 will further explore novel concepts of sampling, filtering and preconcentration of target substances based on nanostructured filter and enrichment materials. The development and the modelling of this new generation of nanostructured gas-sensing and ion emitting materials will be supported by a wide range of morphological and physico-chemical characterisation techniques. The cooperation between EU Union and Russian groups will be improved and strengthened by short and long term exchanges of researchers, the organization of common workshops and tutorials and the establishment of joint doctoral degrees

SA-NANO • • •

Acronym: SA-NANO Project Title: Self Assembly of Shape Controlled Colloidal Nanocrystals Participants:



Project Abstract: Shape controlled nanocrystals increase the functionality of nanoparticles significantly by modifying optical, electrical and chemical properties compared to those of spherical nanocrystals. This can be used advantageously in diverse applications in optics, electronics, bio-medicine, catalysis, but only if viable selfassembly schemes using bottom-up approaches can be realized for these systems. To this end, the project Self Assembly of Shape Controlled Nanocrystals (SA-NANO) will bring breakthrough innovations in the control and understanding of the self-assembly of rod and tetrapod shaped nanocrystals. Rods and tetrapods will be developed so as to posses a functional part and a recognition element for the purposes of self assembly in analogy to biological systems. As one main example, gold tips will be selectively grown on the edges of rods and tetrapods to serve as the recognition elements. These anchor points will be used in the self-assembly of these objects in solution to create rod chains and tetrapod-rod assemblies. Alignment and positioning of these objects onto pre-patterned surfaces, also prepared using self assembly, will be developed. External biases including electric and magnetic fields, as well as microfluidics, will be used to achieve rod alignment and assembly. Theoretical modeling on self-assembly and computation of electronic and optical properties to support the experiments will be also performed. Assemblies of shape-controlled nanocrystals will reveal new collective phenomena that will be studied by diverse techniques including optical spectroscopy, magnetic studies, and scanning probe methods. SA-NANO will advance the self assembly of shape-controlled nanocrystals to the extent that the methods, concepts and understanding of the process will be available for broad implementation in device fabrication based on nanocrystal building blocks, with clear impact for the future of nanotechnology in Europe.

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CONSIGLIO NAZIONALE DELLE RICERCHE (CNR), www.cnr.it , (IT) THE HEBREW UNIVERSITY OF JERUSALEM. (HUJ), www.huji.ac.il , (IL) B.I. STEPANOV INSTITUTE OF PHYSICS OF THE NATIONAL ACADEMY OF SCIENCES OF BELARUS (IP NAS BELARUS), , (BY) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (LCC-CNRS), www.cnrs.fr , (FR) LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN (LMU), www.uni-muenchen.de , (DE) PHOTOCHEMISTRY CENTER RUSSIAN ACADEMY OF SCIENCES (PC RAS), http://photonics.ru , (RU) TEL AVIV UNIVERSITY (TAU), http://www.tau.ac.il/ , (IL) RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG. (UHEI), www.uni-heidelberg.de , (DE)

SANDIE • • •

Acronym: SANDIE Project Title: Self-Assembled semiconductor Nanostructures for new Devices in photonics and Electronics Participants: – – – – – – – – – –

– – – – – – – – – – – – – – – – –

AIXTRON AG (AIXTRON), www.aixtron.com , (DE) BOOKHAM TECHNOLOGY PLC* (BHM), www.bookham.com , (UK) CONSIGLIO NAZIONALE DELLE RICERCHE (CNR-IMEM), www.cnr.it , (IT) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS-DR5-LPN), www.cnrs.fr , (FR) AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), http://www.csic.es , (ES) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (FHI), www.mpg.de , (DE) HERIOT-WATT UNIVERSITY (HWU), www.hw.ac.uk , (UK) INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE RENNES (INSA-RENNES), , (FR) KATHOLIEKE UNIVERSITEIT LEUVEN (K.U.LEUVEN R&D), www.kuleuven.be , (BE) SAINT-PETERSBURG PHYSICO-TECHNICAL CENTRE FOR RESEARCH AND EDUCATION OF THE RUSSIAN ACADEMY OF SCIENCES (LOFFE), www.ioffe.rssi.ru , (RU) LUNDS UNIVERSITET (LU), www.lu.se , (SE) INNOLUME GMBH (NSC), , (DE) TOSHIBA RESEARCH EUROPE LIMITED (TREL), , (UK) TECHNISCHE UNIVERSITEIT EINDHOVEN (TU/E), www.tue.nl , (NL) TECHNISCHE UNIVERSITAT BERLIN (TUB), www.tu-berlin.de , (DE) TECHNISCHE UNIVERSITAET WIEN (TU-WIEN), www.tuwien.ac.at , (AT) UNIVERSITEIT ANTWERPEN (UA), www.ua.ac.be , (BE) E DE AVEIRO (UAVR), www.ua.pt , (PT) DE CADIZ (UCA), www.uca.es , (ES) LANCASTER UNIVERSITY (ULANC), , (UK) TECHNISCHE UNIVERSITAET DORTMUND (UNI DO), www.tu-dortmund.de , (DE) UNIVERSITAET LEIPZIG (UNI LEIPZIG), http://www.uni-leipzig.de , (DE) UNIVERSITAET LINZ (UNILINZ), , (AT) THE UNIVERSITY OF NOTTINGHAM (UNOTT), www.nottingham.ac.uk , (UK) UNIVERSITE PARIS-SUD XI (UPS), www.u-psud.fr , (FR) THE UNIVERSITY OF SHEFFIELD (USFD), www.shef.ac.uk , (UK) UNIVERSITAT DE VALENCIA (UVEG), www.uv.es , (ES)

SANDIE cont. •

Project Abstract: The Network of Excellence is dedicated to the formation of an integrated and cohesive approach to research and knowledge in the field of Self-Assembled semiconductor Nanostructures (SAN). These nanostructures can then be cemented in position by the deposition of further layers of the substrate material. By varying the semiconductor materials involved, the growth conditions, and by vertically stacking layers of nanostructures, a rich variety of novel materials can be produced for the study of the fundamental properties of strongly confined systems, and for the development of advanced electronic and optoelectronic devices. The resources and the approach of the Network reach from the study of fundamental phenomena to their exploitation for the design of novel materials and structures for use in advanced electronic, photonic and optoelectronic devices. In particular the activities on devices are tightly integrated with European industrial partners of the Network. The Network will spread excellence outside the Network, in particular to the new member states via gateway institutes in the new member states. A measurable integration of the human resources, equipment and methods in the European research area will be achieved by the Network with a program of joint activities. The integration pertains to people, facilities, research, training and education and exploitation. In particular the Network funds will be used for supporting the exchange of personnel, joint PhD programs, increased availability, access and throughput of experimental facilities, the design, preparation and execution of joint research projects, education and training programs including workshops, schools and technical training courses, outreach to the scientific community and the general public and the exploitation of scientific and technological results together with the industrial partners.

SANES • • •

Acronym: SANES Project Title: INTEGRATED SELF-ADJUSTING NANO-ELECTRONIC SENSORS Participants: – – – – – –



LASER PROBE LP OY (LASERPROBE), , (FI) MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (MPI-FKF), www.mpg.de , (DE) RENSSELAER POLYTECHNIC INSTITUTE (RPI), www.rpi.edu , (US) UNIVERSITY OF SZEGED (SZTE), www.u-szeged.hu , (HU) OULUN YLIOPISTO (UOULU), www.oulu.fi , (FI) DEL PAIS VASCO (UPV/EHU), www.ehu.es , (ES)

Project Abstract: We propose to develop a new integrated self-adjusting nanoelectronic sensor (SANES) based on functionalized carbon nanotubes as active elements. The multifunctional sensor micromodule will consist of a matrix of differently functionalized CNTs which are integrated into an electronics package (electronics and software also developed in the framework of the project) capable of: - recording and analyzing the signal of a very small number (target: only one single nanotube) of sensing elements - monitoring several factors (e.g. temperature, pressure, gas atmosphere etc.) simultaneously - actively change the local chemical environment of the sensor component CNTs (self-adjusting behavior) The primary objective of this proposal is to design, construct and analyse such novel sensor modules integrated in an intelligent micromodule. We intend to build the working prototype of the modul and perform its complete evaluation regarding sensitivity, selectivity, stability and reproducibility. We will conclude the project by performing a feasibility study on the possibilities of the production scale-up for the developed sensor module.

SANS • • •

Acronym: SANS Project Title: Sensitizer Activated Nanostructured Solar Cells Participants:



Project Abstract: Widespread uptake of inorganic semiconductor solar cells has been limited, with current solar cell arrays only producing between 4 to 7 GW of the 15 TW (

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