Development of Methods for the Determination of pKa Values

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Anal Chem Insights. 2013; 8: 53–71.

PMCID: PMC3747999

Published online 2013 Aug 8. doi: 10.4137/ACI.S12304

PMID: 23997574

Development of Methods for the Determination of pKa Values Jetse Reijenga, Arno van Hoof, Antonie van Loon, and Bram Teunissen Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands. Corresponding author email: [email protected] Copyright © 2013 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 license. This article has been cited by other articles in PMC.

Abstract

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Introduction

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History

Influences on pKa

Complications and overview

Techniques

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Potentiometry

Conductometry

Voltammetry

Calorimetry

Nuclear magnetic resonance

Electrophoresis

High performance liquid chromatography

Partition and distribution

Solubility

UV/Vis spectrometry

Fluorometry

Polarimetry

Kinetic method

Computational method

Comparison and Discussion

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Table 1

Conclusion and Recommendations

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Footnotes

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Author Contributions Entire literature search and first draft versions of manuscript chapters: AHM van Loon, AJF van Hoof, AJP Teunissen. Jointly developed the final structure, illustrations and revised chapters of the paper: AHM van Loon, AJF van Hoof, AJP Teunissen, JC Reijenga. Made critical revisions and approved final version: JC Reijenga. All authors reviewed and approved of the final manuscript. Competing Interests Author(s) disclose no potential conflicts of interest. Disclosures and Ethics As a requirement of publication the authors have provided signed confirmation of their compliance with ethical and legal obligations including but not limited to compliance with ICMJE authorship and competing interests guidelines, that the article is neither under consideration for publication nor published elsewhere, of their compliance with legal and ethical guidelines concerning human and animal research participants (if applicable), and that permission has been obtained for reproduction of any copyrighted material. This article was subject to blind, independent, expert peer review. The reviewers reported no competing interests. Funding Author(s) disclose no funding sources.

References

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Articles from Analytical Chemistry Insights are provided here courtesy of SAGE Publications

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Development of Methods for the Determination of pKa Values

Anal Chem Insights. 2013; 8: 53–71. PMCID: PMC3747999 Published online 2013 Aug 8. doi: 10.4137/ACI.S12304 PMID: 23997574 Development of Methods f...

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