Trials. 2011; 12: 170.
PMCID: PMC3155116
Published online 2011 Jul 6. doi: 10.1186/1745-6215-12-170
Early postoperative cognitive dysfunction and postoperative delirium after anaesthesia with various hypnotics: study protocol for a randomised controlled trial - The PINOCCHIO trial Federico Bilotta, 1 Andrea Doronzio, 1 Elisabetta Stazi, 1 Luca Titi, 1 Ivan Orlando Zeppa, 1 Antonella Cianchi, 1 Giovanni Rosa, 1 Francesca Paola Paoloni, 2 Sergio Bergese, 3 Irene Asouhidou, 4 Polimnia Ioannou, 4 Apolonia Elisabeth Abramowicz, 5 Allison Spinelli, 5 Ellise Delphin, 5 Eugenia Ayrian, 6 Vladimir Zelman, 6 and Philip Lumb6 1 Department of Anaesthesiology, Critical Care and Pain Medicine, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy 2 GIMEMA, Data Center, Rome, Italy 3 Departments of Anesthesiology and Neurological Surgery, The Ohio State University, Columbus, OH, USA 4 Second Department of Anesthesiology "G.Papanikolaou" General Hospital, Exohi Thessaloniki, Greece 5 Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, The Bronx, NY, USA 6 Department of Anesthesiology, University of Southern California, Los Angeles, CA, USA Corresponding author. Federico Bilotta:
[email protected]; Andrea Doronzio:
[email protected]; Elisabetta Stazi:
[email protected]; Luca Titi:
[email protected]; Ivan Orlando Zeppa:
[email protected]; Antonella Cianchi:
[email protected]; Giovanni Rosa:
[email protected]; Francesca Paola Paoloni:
[email protected]; Sergio Bergese:
[email protected]; Irene Asouhidou:
[email protected]; Polimnia Ioannou:
[email protected]; Apolonia Elisabeth Abramowicz:
[email protected]; Allison Spinelli:
[email protected]; Ellise Delphin:
[email protected]; Eugenia Ayrian:
[email protected]; Vladimir Zelman:
[email protected]; Philip Lumb:
[email protected] Received 2010 Apr 30; Accepted 2011 Jul 6. Copyright ©2011 Bilotta et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC.
Abstract
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Background
Methods/Design
Discussion
Registered at Trial.gov Number
Background
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Propofol
Sevoflurane
Desflurane
Fentanyl
Methods
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Inclusion and exclusion criteria
Statistical Analysis Sample Size
Ethical considerations
Results
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Discussion
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Abbreviations
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Competing interests
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Authors' contributions
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Appendix
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Acknowledgements
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References
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