Edythe D - David Geffen School of Medicine at UCLA [PDF]

Edythe D. London, Ph.D. CURRICULUM VITAE Personal:

Born: Rome, Italy Citizenship: U.S.A

Address:

Semel Institute on Neuroscience and Human Behavior, UCLA 760 Westwood Plaza, Room C8-831 Los Angeles, CA 90024-7085

Telephone:

310-825-0606 (voice), 310-825-0812 (facsimile)

Education:

The George Washington University Major in zoology, minor in chemistry Bachelor of Science, 1969 Towson University Master of Science (Biological Sciences), 1973 University of Maryland Pharmacology, supporting program in Neurobiology Doctor of Philosophy, 1976 Johns Hopkins School of Medicine Dept. Pharmacology & Experimental Therapeutics Postdoctoral Fellow in Neuropsychopharmacology, 1976 – 1978

Present Position: Thomas P. and Katherine K. Pike Professor in Addiction Studies, Dept. Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, UCLA (since Sept 2008) Professor-in-Residence, Dept. Psychiatry & Biobehavioral Sciences; and Dept. Molecular & Medical Pharmacology, (since July 2001) Member of the Interdepartmental Neuroscience Faculty, David Geffen Sch. Medicine, UCLA (since 2003) Previous Academic Appointments: Jan 1987 - Jun 1999:

Adjunct Professor, Dept. Pharmacology and Experimental Therapeutics, Univ. Maryland School of Medicine

Mar 1987 - Feb 2000: Associate Professor of Radiology, Part-time. Department of Radiology, School of Medicine, Johns Hopkins University Sep 1998 – Jun 2001: Previous Positions: Jan 1979 - Dec 1981: Dec 1981 - Sep 1982: Sep 1982 - Aug 1984: Aug 1984 - Jul 1985: July 1985 - June 1992: June 1992 - July 1999: July 1999 - June 2001:

Visiting Professor, Department of Psychiatry & Biobehavioral Sciences Neuropsychiatric Institute, School of Medicine, UCLA Staff Fellow, Laboratory of Neurosciences, Gerontology Research Center, NIA Pharmacologist, Laboratory of Neurosciences, Gerontology Research Center, NIA Pharmacologist, Clinical Pharmacology Branch, Addiction Res. Center, NIDA Acting Chief, Neuroscience Branch, Addiction Research Center, NIDA Chief, Neuropharmacology Lab., Addiction Research Center, NIDA Chief, Brain Imaging Section and Director of the Brain Imaging Center, NIDA Research Pharmacologist, NIDA (at UCLA, Interagency Personnel Agreement)

Updated December 29, 2011

Curriculum Vitae - Edythe D. London, Ph.D.

Consultation in 2006 – 2011: Beth Israel Hospital NY (New York, NY); Duke University Center for Nicotine & Smoking Cessation Research; Mt. Sinai College of Medicine. Previous Consultation: Eli Lilly Corp. (Indianapolis, IN); Immulogic Corp. (Cambridge, MA), Pharmaceutical Peptides, Inc. (Cambridge, MA), DuPont Merck (Wilmington, DE), Merck (Harlow, Essex, UK), Searle Pharmaceutical Corp. (Skokie, IL), Friends Research Institute, Inc. (Los Angeles, CA); Abbott Laboratories (Abbott Park, IL); Pharmacia –Upjohn Corp. (Kalamazoo, MI). Service on Government and University Committees: Animal Care Advisory Comm., Gerontology Research Ctr., NIA (1980–1982), Chair (1982-1986). Radiation Safety Comm., Francis Scott Key Med. Ctr., Johns Hopkins Sch. Medicine (1988-1991). Women’s Advisory Committee, NIDA (1990 – 1991). Streamlining Workshop, NIDA (1995). Tenure Track Recruitment Committee, NIMH (1996 – 1997). Animal Care and Use Committee, NIDA (1996 – 1997). Tenure and Promotions Committee, Gerontology Research Center, NIA (1982 – 1999). Chair, Promotions and Incentives Committee, NIDA (1995 – 1999). Central Tenure Committee, NIH (1996 – 1999). Proposal Evaluation Board for CTAC/ONDCP (2001 – 2003). UCLA Institutional Review Board (July 1, 2000 – June 30, 2001). Duke Center for Nicotine Research Advisory Committee (2004 - present) UCLA Dept. Psychiatry and Biobehavioral Sciences, Academic Advancement Committee (2006 – present) UCLA Dept. Psychiatry & Biobehav. Sci., Ad Hoc Committees for recruitment, promotion (1999 – present) UCLA Dept. Psychiatry and Biobehavioral Sciences, Junior Faculty Mentoring Committee (2007 - present) UCLA Dept. Psychiatry and Biobehavioral Sci., Phenomics & Clinical Research Study Group (2009 – present) Drew University Minority Institutions’ Drug Abuse Res. Development Program (MIDARP) (2006 – present) UCLA Admissions Committee for Neuroscience Interdepartmental Program (2010/2011, 2011/2012) Grant Review: National Science Foundation, 1981-1982. Medical Research Council of Canada, 1985. NIDA Extramural Research Program, 1987. Special Review Committee, NIDA, June, 1989. Initial Review Group, NIDA, June, 1989. Veterans Administration, October, 1990. National Science Foundation, November, 1990. Nuclear Medicine Research Program, Dept. of Energy, May, 1992. Special Review Committee, NIDA, August, 1992. Tobacco-Related Disease Program, University of California, May, 1994, 1997, 1999. Program Merit Review for Department of Veterans' Affairs, 1996 and 1997. NIDA Transdisciplinary Prevention Research Centers, 2003 National Cancer Institute (NCI) Small Animal Imaging Resource Program, March, 2004 NCI Review Group: ZCA1 SRRB-C (M1), 2003 NIDA Scientific Review Group (NIDA-L-2). February, 2005 NIH Center for Scientific Review, Biomedical Imaging, Shared Instrumentation Grants. June, 2005 NIH Center for Scientific Review, Imaging Science Track Award for Research Transition April, 2007 NIH Center for Scientific Review, Bioengineering Res. Partnership, special emphasis panel, May 30, 2007. NIDA Special Emphasis Panel, June, 2007. Clinical Research Review Committee, NCRR, ad hoc reviewer of CTSI applications, September 2008 NIDA Special Emphasis Panel, Go grants, August, 2009 2

Curriculum Vitae - Edythe D. London, Ph.D.

Membership on standing NIH Review Committees: Clinical Research Review Committee, National Center for Research Resources, 2006-2008 Neural Basis of Psychopathology & Sleep Disorders, July, 2008–June, 2012 (Chair July, 2011- June, 2012) Editorial Advisory Boards, past membership: Neurobiology of Aging, January 1982 – December, 1993 Experimental Neurology, October 1990 – January, 1996 Neuropsychopharmacology, July 1999 – June, 2002 Frontiers in Molecular Psychiatry (Associate Editor), Dec. 2009 – Jan. 2011 Editorial Advisory Boards: current membership: Synapse, since January, 1999 Addiction Reviews (Annual Review series, New York Academy of Sciences), since July, 2007 American Journal on Addictions, since February, 2008 Journal of Experimental Pharmacology, since August, 2009 American Journal of Drug & Alcohol Abuse, since January, 1987 Psychopharmacology, since July, 2009 Journal of Addiction Research & Therapy, since November 2010 World Journal of Pharmacology, since January 2011 Ad hoc reviews for these and others scientific journals: Am. J. Psychiatry, Arch. Gen. Psychiatry, Biol. Psychiatry, Brain Res. Bull., Clin. Pharmacol. Ther., CNS Spectrums/CNS Drug Rev., Drug Alc. Depend., Exp. Neurol., J. Neurosci., J. Cereb. Blood Flow Metab., Frontiers Human Neurosci., J. Neurochem., J. Neurosci., J. Nucl. Med., J. Pharmacol. Exp. Ther., Life Sci., Mol. Imaging Biol., Mol. Psychiatry, NeuroImage, Neuropsycho pharmacology, Nicotine & Tobacco Res., Proc. Natl. Acad. Sci., Science, Trends Cog. Sci., Trends Pharmacol. Sci. Service on Government and University Committees: Animal Care Advisory Comm., Gerontology Research Ctr., NIA (1980–1982), Chair (1982-1986) Radiation Safety Comm., Francis Scott Key Med. Ctr., Johns Hopkins Sch. Medicine (1988-1991) Women’s Advisory Committee, NIDA (1990 – 1991) Streamlining Workshop, NIDA (1995) Tenure Track Recruitment Committee, NIMH (1996 – 1997) Animal Care and Use Committee, NIDA (1996 – 1997) Tenure and Promotions Committee, Gerontology Research Center, NIA (1982 – 1999) Chair, Promotions and Incentives Committee, NIDA (1995 – 1999) Central Tenure Committee, NIH (1996 – 1999) Institutional Review Board, UCLA (July 1, 2000 – June 30, 2001) University Senate and Ad Hoc Committees for Advancement and Promotion (2002 – 2003) Proposal Evaluation Board for CTAC/Off. Natl. Drug Control Policy (2001 – 2003) Chair, Advisory Panel on Demand Reduction, Office of National Drug Control Policy, 1994. Semel Institute Director’s Forum (October, 2007 – present) Appointments and Advancements committee, UCLA Department of Psychiatry (2005- present) Other Commmunity Service: Judge, Arthur Flemming Awards, given by Downtown Jaycees, Wash. DC (1989, 1990). Alumni Advisory Board, College of Natural & Math. Sciences, Towson State. Univ., 1994 - 1999. Contributor, “Target America: Opening Eyes to the Damage Drugs Cause” CA Science Center Exhibit, opened October 1, 2008 Executive Council, Betty Ford Institute (October 2010 to present) 3

Curriculum Vitae - Edythe D. London, Ph.D.

Membership and Service in Professional Societies: American Society for Pharmacology and Experimental Therapeutics International Soc. of Cerebral Blood Flow & Metabolism (Founder member) Society for Neuroscience (Member since 1976) American Association for the Advancement of Science Mid-Atlantic Acetylcholine Discussion Group (Co-chair, 1979-1982) American Society for Neurochemistry (1982 - 1997) American College of Neuropsychopharmacology, ACNP (Member since 1989, Fellow since 2001) Credentials Committee (2004) Program Committee (2004-2006), Animal Committee (December, 2009 – December, 2010) Nominating Committee (elected by membership for 2012) Public Information Committee (since December, 2008) Society for Research on Nicotine and Tobacco (Member since 1995) College on Problems of Drug Dependence (Member 1997, Fellow 2000, Board of Directors (1997-2001); Credentials Committee (2000-2001); Program Committee (2003 – 2006) International Society for Pain and Chemical Dependency, International Advisory Board (2003; 2004) New York Academy of Sciences (member since July, 2007) Neuroreceptor Mapping (NRM 12) International Scientific Board, 2011-21012 Honors and Awards: Abigail Ann Brown and Henry Kirk White Scholarship, George Washington University, 1966-1967 Research Fellowship, Dept. Pediatric Res., Univ. of Maryland School of Medicine, summer 1967 Friendship Business and Professional Women's Scholarship, 1967-1968, 1968-1969 George Washington University Board of Trustees Scholarship, 1968-1970 Emerson Fellowship, University of Maryland, 1974 - 1976 Rho Chi Pharmaceutical Honorary Society, elected 1975 National Institute on Mental Health Postdoctoral Fellowship, 1976 to 1978 Mathilde Solowey Lecture Award in the Neurosciences, 1987 ADAMHA Administrator's Award for Equal Employment Opportunity Achievement, 1988 NIDA Director's Award for Significant Achievement, July 1990. Dean's Recognition Award to Outstanding Alumna, Towson University, 1996 NIDA Director’s Merit Award: Radiotracer for Nicotinic Acetylcholine Receptors, Oct 1998. Fellow, College on Problems of Drug Dependence, 2000 Fellow, American College of Neuropsychopharmacology, 2001 Marian W. Fischman Lectureship Award to outstanding woman scientist, College on Problems of Drug Dependence, June 16, 2008. Sierra Tucson’s Gratitude in Giving Award, Vision Recognition to a researcher who has expanded knowledge and understanding through scientific inquiry, June 9, 2010. The American Journal on Addictions’ distinguished Basic Science Scholar on Addictions, pending delivery of invited article. American Assoc. for the Advancement of Science, 2011 Scientific Freedom and Responsibility Award, Feb. 17, 2012.

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Curriculum Vitae - Edythe D. London, Ph.D.

Patents: Inhibitors of nitric oxide synthase (NOS) and their use to prevent glutamate neurotoxicity. Patent 07,881,900, VL Dawson, TM Dawson, ED London, DS Bredt, and SH Snyder. Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase. Patent 5,225,440, ED London and AS Kimes. Jul 6, 1997 A method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-azabicyclo[2.2.1] heptanes. Patent 5,726,189. ED London, AS Kimes, A Horti, RF Dannals, M Kassiou. Mar 10, 1998 Radiolabeled pyridyl-7-azabicyclo [2.2.1]heptanes.Patent #5,969,144, ED London, AS Kimes, A Horti, RF Dannals, M Kassiou. Awarded: Oct 19, 1999 (divisional – see Patent # 5,726,189). Funding Received (E. London is Principal Investigator or Program Director on each): Hydergine® Effects on Brain Glucose Metabolism. Sandoz, Ltd.; $40,000, Jul, 1983-Jun. 1985. Effects of Opioid Agonist and Antagonist Drugs on Local Cerebral Glucose Utilization. E.I. Dupont De Nemours & Co.: $24,006, Jul. 1984 – Jun. 1985. Effects of CL220,075 on Cerebral Glucose Utilization. Am. Cyanamid Co.: $4,200, Sept. 1985 – Nov. 1985. Effects of Hydergine® on Hippocampal Glucose Utilization Following Septal Lesions. Sandoz, Ltd.: $29,400, May 1986 – Apr. 1987. Developing a Positron Emission Tomography Facility for Study of Substance Abuse. Office of Natl. Drug Control Policy, Executive Office of the President, $5,982,000, 1993. Nicotine Withdrawal, Smoking & Cognition: fMRI Study. NIH/NIDA: $1,056,789, Sept. 2001 – Apr 2005. Nicotine Withdrawal, Smoking & Attention: fMRI Study. UC Tobacco Related Disease Research Program: $475,303, Jul. 2001 – Jun. 2005. Nicotine Withdrawal, Smoking & Cognition: fMRI Study. Philip Morris External Research Program: $713,367, Feb. 2002 – Jan. 2005. PET and Stereotactic Probes to Develop Therapeutic Interventions for Drug Abuse, Office of Natl. Drug Control Policy, Executive Office of the President: $3,730,503; 2000–2006. Early Methamphetamine Abstinence: fMRI and Cognition. NIH/NIDA: $1,182,287, July 2003–April 2006. Neural Systems, Inhibitory Control and Methamphetamine Dependence. R01 DA020726 (NIH/NIDA): $1,262,898, 9/2005 – 8/2009. Methamphetamine Abuse & Inhibitory Control: Implications for Treatment. P20 DA022539 (NIH/NIDA): $3,350,476, Sept. 2006 – Aug. 2010. UCLA Adolescent Smoking Cessation Center: UCLA Contract No. 20063287 (Philip Morris USA): $8,000,000, Nov. 2006 – Dec. 2011. Response Inhibition and Dopamine Neurotransmission (Linked RL1 in Consortium for Neuuropsychiatric Phenomics) NIH/NIDA: $1,165,328, Oct. 2007-Sept. 2012. UCLA Training Prog. in Translational Neurosci. Drug Abuse, NIH/NIDA (T32 program for pre- and postdoctoral fellows): $1,0512,121, Jul. 2008-Jun. 2012. Educational Outreach Initiative, Am. College of Neuropsychopharmacology: $5,000, Jan. 2008-Dec. 2009. Invited Lectures and Participation in Scientific Meetings: Mid-Atlantic Acetylcholine Discussion Group "Cholinergic Involvement in Alzheimer's Disease", May 23, 1980, Cornell Medical College, New York, NY. Co-chair, organizer. Eur. Atherosclerosis Group, May 26-27, 1981, Padova, Italy. "Cerebral Glucose Utilization during Aging of the Rat & Dog: Implications for Man during Aging & Dementia." Mid-Atlantic Acetylcholine Disc. Group, Jun 17, 1981, Gerontol. Res. Ctr., Balto., MD. Lecture "Cerebral Metabolic Responses to the Muscarinic Agonist Oxotremorine." Gordon Research Conference, "Biology of Aging", Feb 1982, Ventura, CA. "Age-Related Increase in Vmax for Choline Acetyltransferase in Brain Regions of C57BL/6J Mice", "Effect of Age on OxotremorineInduced Stimulation of Local Cerebral Glucose Utilization".

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Curriculum Vitae - Edythe D. London, Ph.D.

Eur. Soc. Neurochem./World Fed. Neurol. Meeting: Energy Transduction & Neurotransmission, Sept. 1982, Rome, Italy. "Age-related Decrease in Oxotremorine-induced Stimulation of Brain Glucose Utilization." Univ. MD, Balto. Co., Dept. Chemistry - Jan 10, 1983. "Neurobiology of Aging." Sloane-Kettering Cancer Res. Ctr., New York, NY - Jan 14, 1983. "Metabolic Mapping with Deoxyglucose: Studies of Aging & Cholinergic Function." Winter Conf. Brain Res. - Jan 1983, Keystone, CO. "CNS Effects of Vasopressin." Ohio State Univ., Columbus, Feb 17, 1983. "Metabolic Mapping in Brain: Aging & Cholinergic Function." 5th Int. Conf. on Acetylcholine, Nov 1983, Oglebay Park, West Virginia. "Relations between Choline Acetyltransferase & Muscarinic Binding in Aging & Alzheimer's Disease." Div. Nuclear Medicine, Johns Hopkins Hosp., Dec 12, 1983. "In Vivo Mapping of Cerebral Metabolic Effects of Opioid Agonist & Antagonist Drugs with Radiolabelled Deoxyglucose." Univ. MD, Balto. County, Dept. Chemistry - Jan 11, 1984. "Neurobiology of Aging." Johns Hopkins Sch. Med., Dept. Neurosci., Mar 1, 1984. "Models of Cholinergic Deficits in Aging Brain." Symposium: Pharmacology of Hydergine® (Sandoz Corp.), Paris, Oct, 1984. "Enhanced Local Glucose Utilization in Many Subcortical Regions of the Rat Brain Following Acute Co-dergocrine Treatment." Univ. MD, Balto. County, Dept. Chemistry - Jan 9, 1985. "Neurobiology of Aging." Johns Hopkins Medical Institutions, course on Neuroreceptors & Positron Emission Tomography. Mar 15, 1985. "Drug Addiction & Brain Chemistry" OHOLO Biological Conf. on Basic & Therapeutic Strategies in Alzheimer's & Related Neuropsychiatric Disorders, Mar 24-27, 1985, Eilat, Israel. "Reversing Cerebral Metabolic Deficits in Rodent Models for Aging & Alzheimer's Disease." Uniformed Services Univ. of Health Sciences, Dept. Psychiatry, May 8, 1985. "Deoxyglucose Studies of Opioid Dependence & Abstinence." Int. Cong. Gerontology, Jul 14, 1985, New York, NY. "Cholinergic Deficits in Aging & Alzheimer's Disease." Armed Forces Radiobiol. Res. Inst., Apr 30, 1986. "Cerebral Metabolic Effects of Abused Substances." Johns Hopkins Med. Inst., Mar 28, 1986. "Cerebral Metabolic Effects of Psychoactive Drugs" in course on Neuroreceptors & Positron Emission Tomography. Dept. Psychiatry, Sch. Med., Southern IL Univ., May 5, 1986. "Mapping Cerebral Effects of Abused Drugs." Grass Foundation Traveling Scientist Program, May 5, 1986, Sangamon County Chapter, Soc. Neurosci. "Brain Imaging Techniques in Psychopharmacology." Central Inst. Exp. Anims., Nov. 25, 1986, Kawasaki, Japan. "Mapping the Cerebral Effects of Abused Drugs." Nuclear Medicine Div., Dept. Radiology, Queen Mary Hosp., Nov 28, 1986, Hong Kong. "Metabolic Mapping of Cerebral Drug Action." AMERSA Natl. Conf., Dec 10, 1986, Wash, DC. "Imaging Cerebral Effects of Psychoactive Drugs." Collegium Internationale Neuropsychopharmacologicum (CINP), 15th Annual Meeting, Dec. 1986, San Juan, PR. "Mapping Cerebral Distributions of Action of Euphoriant Drugs". Grass Foundation Traveling Scientist Program, Apr 24, 1987, Middle TN Chapter, Soc. Neurosci. "Mapping Pathways of Drug-Induced Euphoria." Am. Soc. Pharmacol. Exp. Ther., Aug 1987. "Distribution of Cerebral Metabolic Responses to Ligands & Phencyclidine" in symposium "Biochemical & Pharmacological Characterizations of HaloperidolSensitive Receptors: Comparison with PCP Receptors." FASEB, May 1988, Las Vegas, NV. Symposium Chair, "New Insights: Molecular & Behavioral Actions of Cocaine." Lecture, "Mapping Cerebral Distributions of Cocaine's Action--Relation to Behavioral Effects." European Soc. Neurochem., Jun 13, 1988, Gothenburg, Sweden. Co-chaired symposium "Imaging Techniques to Study Brain Function". Lecture "Cerebral Metabolic Effects of Euphorigenic Drugs". Joint meeting Am. Physiol. Soc. & Am. Soc. Pharmacol. Exp. Ther., Oct 13, 1988, Montreal. "Neurochemical & Functional Measures of Cholinergic Neurotransmission in the Aging Brain." Grand Rounds, Dartmouth Med. School, Aug 1, 1989. "Brain Imaging Studies of Psychotropic Drugs." Brookhaven Nat. Lab., Upton, NY, Jan 4, 1990. "Mapping Metabolic Correlates of Drug-Induced Euphoria." 6

Curriculum Vitae - Edythe D. London, Ph.D.

Dept. Pharmacol. & Toxicology, School of Pharmacy, Univ. MD, Feb 28, 1990. "Mapping the Metabolic Correlates of Drug-Induced Euphoria." Johns Hopkins Med. Inst., Mar 15-16, 1990. “Sigma Receptors in Mental Disorders", "Brain Chemistry of Euphoria" in course "Drugs, Behavior & the Brain: Advances in PET & SPECT Imaging." Am. Psychiatric Assoc., 143rd Ann. Meeting, New York, NY, May, 1990. "Decreased Brain Glucose Utilization by Morphine", "Decreased Brain Glucose Utilization by Cocaine." FASEB Satellite Symposium "Properties of the Neuroleptic-Sensitive Sigma-DM System", Apr 1, 1990, Wash. DC. Lecture: Studies of σ Receptors & Metabolic Responses to σ Ligands in Brain. Grand Rounds, Dept. Psychiatry, Children's National Medical Center, Wash., DC. Jun 1, 1990. "PET Scan Studies of Euphoriant Drug Action in the Brain." Committee on Problems of Drug Dependence, Ann. meeting, Jun 11, 1990, Richmond, VA. "Mapping the Metabolic Correlates of Drug-Induced Euphoria." Int. Symposium on Nicotine, Jun 28-30, 1990, Hamburg, FRG. "Glucose Metabolism: An Index of Nicotine Action in the Brain." 17th Cong. CINP, Satellite Symposium on NMDA Receptor, Sept 16-17, 1990, Nagoya, Japan. "Polyamines as Regulators of Cationic Channels in the CNS." Medical & Chirurgical Faculty of MD "Practical Clinical Mgt.: Drug Abuse Education for the Primary Care Physician", Oct 20, 1990. "PET Scan Mapping of the Cerebral Effects of Abused Drugs." Brown Univ., Oct 25, 1990. Colloquium Lecture, “Taking the High Road - Cerebral Metabolic Correlates of Drug-Induced Euphoria.” Am. College Neuropsychopharmacol. Annual meeting, Dec 9-14, 1990, San Juan, PR. “Acute Effects of Cocaine on Cerebral Glucose Metabolism in Substance Abusers”; "Sigma Receptor Deficits in Schizophrenia: Post-mortem Studies Suggest a Potential for PET Diagnosis." Am. Psychiatric Assoc., 144th Annual meeting, New Orleans, LA, May 12-14, 1991. "Brain Metabolism and Drug-Induced Euphoria" in symposium "PET Studies of Drug Abuse." Int. Symposium on Nuclear Imaging in Drug Discovery, Development, & Approval, Merck Sharp & Dohme, Balto., MD, Jun 19, 1991. "Effects of Intravenous Cocaine on Cerebral Glucose Utilization in Human Polydrug Abusers: Relations Between Regional Metabolism & Subjective Responses." 3rd IBRO World Cong. Neurosci., Montreal, Canada, Aug 7, 1991. "Ligand-Binding Studies of Polyamine Receptors in the Brain"; "Mapping the Effects of Nicotine on Metabolism in the Living Brain." 3rd French-U.S. Seminar "Multiple Sigma & PCP Receptor Ligands: Neuromodulation & Protection." La Grand Motte, France, Sept 16-19, 1991. “Ligand-binding Studies of Polyamine Receptors in Rat Brain.” Soc. Neurosci., 21st Ann. meeting, New Orleans, LA, Nov 10-15, 1991. "The Neurochemical and Biochemical Basis of the Opioid Abstinence Syndrome Studied through Metabolic Mapping" in symposium "Insights into Brain and Spinal Components of the Opiate Withdrawal Syndrome." 8th Ann. Einstein Symp. Psychiatry, Albert Einstein Coll. Med. & Montefiore Med. Ctr., Dept. Psychiat., Nov 22, 1991. "The Anatomy of Euphoria: In Vivo Brain Imaging of Cocaine Abusers." Am. Coll. Neuropsychopharmacology, San Juan, PR, Dec 8-13, 1991. "Imaging with PET to Investigate Drug Actions in Brain" in symposium "PET vs. SPECT in Neuropsychopharmacol. Research". CoChaired Panel “Sigma Receptor: Biochem., Physiol. & Clinical Potential.” International Biomed. Res. Conf. on Drug Abuse, sponsored by NIDA and the US Dept. of State, Sea Island, GA, Feb 23-26, 1992. "Seeing the Brain - The Role of PET and other Imaging Techniques." Am. College of Nuclear Physicians 18th Ann. meeting, San Diego, CA, Mar 1-5, 1992. "Effects of Acute Exposure of Drugs of Abuse on Regional Brain Metabolism." Dept. Psychiatry, Univ. of PA, May 11, 1992. "PET Studies of Substance Abusers." Medications Development Division, NIDA. "PET Studies of Substance Abusers" in Seminar on PET and SPECT in Medications Development. International Symposium on Contraband and Cargo Inspection Technology, sponsored by Office of National Drug Control Policy and NIJ, Wash., DC, Oct. 27-30, 1992. “PET and Drug Abuse.” 7

Curriculum Vitae - Edythe D. London, Ph.D.

Grand Rounds, Dept. of Pharmacology, University of Texas Health Science Center, Houston, TX, Apr 14, 1993. “Effects of Acute Cocaine Administration on Brain Metabolism.” University of Vermont, Burlington, VT, Apr. 19, 1993. “Taking the High Road: Studies of Substance Abuse Using Brain Imaging” and “Polyamines and the NMDA receptor.” Grand Rounds, Psychopharmacology Clinic, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, Apr 28, 1993. "PET in the Study of Substance Abuse." Dept. Psychiatry, Yale Univ., West Haven, CT, May 3, 1993. “Brain Imaging in Relation to Substance Abuse." First Turkish Neurosci. Cong., Istanbul, Oct. 1993. “PET in Studies of Substance Abuse.” Dept Anatomy, Sch. Med., Howard Univ., Wash., DC, May 4, 1994. ”Brain Imaging and Drug Abuse.” Dept. Psychiatry, School of Medicine, University of Buffalo, Buffalo, NY, May 6, 1994. Grand Rounds “Structural and Functional Brain Imaging in Drug Abusers.” Am. Psychiatric Assoc., Philadelphia, PA, May 23, 1994. “Brain Metabolism in Substance Abusers.” NY Acad. Sci. Symposium on Functional Diversity of Interacting Receptors, Wash., DC, May 25-28, 1994. “Polyamines as Endogenous Modulators of NMDA Receptor and Other Ligand-Gated Ion Channels.” Coll. Problems of Drug Depend., Palm Beach, FL, Jun 18-23, 1994. “Brain Metabolism in Drug Abusers.” NIDA Technical Review on Neurotoxicity of Cocaine, Wash., DC, Jul 7-8, 1994. “Brain Imaging Studies of Substance Abusers: Acute and Long-Term Effects of Stimulants.” Symposium on Neuroimaging and Drug Dependence, Tokyo, Japan, Aug 9-14, 1994, Special Lecture: “Brain Imaging Studies of Substance Abusers.” Welcome Frontiers Meeting, London, England, Sept 16-21, 1994. ”Biol., Social & Clin. Bases of Addiction.” Univ. Maryland, Baltimore, MD, Sept 26, 1994. “Brain Imaging Studies of Substance Abusers.” Johns Hopkins Medical Institutions Science Writers Seminar “Understanding Addiction”, Baltimore, MD, Sept 27, 1994. “Where Does Craving Live in the Brain.” NIDA Technical Review on Role of Glutamatergic Systems in the Development of Opiate Addiction, Gaithersburg, MD, Oct 17-18, 1994. Discussant “Clinical Implications for Treatment of Opiate Addiction.” Eleventh Annual Symposium in Psychiatry, New York, NY, Nov 4, 1994. “Functional Assessment of Opiate Actions by Brain Imaging.” Towson Univ., Balto., MD, Nov 22, 1994. “Taking the High Road: PET to Study Drug Abuse.” Behav. Pharmacol. Res. Unit, Johns Hopkins Sch. Med., Balto., MD, Nov 29, 1994. “PET in Drug Abuse.” German Society for Research on Drugs and Addiction, Frankfurt, Germany, Dec 2-4, 1994. “Positron Emission Tomography in Studies of Substance Abuse.” Sch. Hygiene & Pub. Hlth., Johns Hopkins Med. Inst., Jan 9, 1995. “PET Studies in Substance Abuse.” Pfizer Central Res., Groton, CT, Jan 17, 1995. “PET Scanning Studies in Substance Abusers.” DuPont Merck Pharmaceutical Co., Wilmington, DE, Jan 18, 1995. “Imaging Craving in the Brain.” NIDA Advisory Council, Bethesda, MD, Feb 7, 1995. “Brain Imaging Studies of Drug Abuse.” NHLBI, NIH, Bethesda, MD, Feb 10, 1995. “PET Studies of Drug Abuse.” Univ. MI Med. Ctr., Jackson, May 26, 1995. Grand Rounds “Brain Img. Studies of Substance Abusers.” FASEB Summer Conf. on Drug Abuse, Copper Mountain, CO, Jul 23-28, 1995. “Brain Imaging: Acute Responses to Stimulants and Persistent Differences in Drug Abusers Compared with Controls.” Counterdrug Technology Assessment Ctr., Off. Natl. Drug Control Policy, “Int. Workshop on Drug Abuse Treatment Tech.”, Balto., MD, Aug 15-16. “New Approaches to Understanding Drug Abuse.” Univ. TX Health Science Center, “Drug Abuse in the Decade of the Brain Conference”, Houston, TX, Sept 22-23, 1995. “Effects of Cocaine on the Brain and Imaging Techniques.” Med. Coll. Wisconsin, Milwaukee, WI, Mar 5, 1996. Grand Rounds “Brain Img. in Substance Abuse.” Eur. Winter Conf. on Brain Res., Serre-Chevalier, France, Mar 16-23, 1996. "FDG and PET Studies of Brain Metabolism and Volumetric MRI Analysis in Substance Abusers and Controls." Pharmaceutical Peptides Incorporated, Cambridge, MA, Jun 3-4, 1996. "Positron Emission Tomography, Cholinergic Receptors, and Alzheimer's Disease." TX A&M Faculty Neurosci., College Station, TX, Oct. 23, 1996. “Brain Imaging and Substance Abuse.” 8

Curriculum Vitae - Edythe D. London, Ph.D.

Am. Soc. Addiction Medicine 9th National Conference on Nicotine Dependence, Wash., DC, Nov 14-17, 1996. “Interactions of Nicotine with Specific Receptors and Circuits in Brain.” Soc. Neurosci. 26th Ann. Meeting, NIDA Satellite Symposium “Cognitive Neuroscience”, Wash., DC, Nov 16-21, 1996. “Activation of Memory Circuits During Cocaine Craving: PET Studies.” Am. College Neuropsychopharmacol. 35th Ann. meeting, San Juan, PR, Dec 9-13, 1996. Co-Chaired Panel “Controversies in Nicotine and Tobacco Smoking Actions.” Beth Israel Med. Center, New York, NY, Feb 20, 1997. Grand Rounds “Brain Imaging and Drug Abuse.” School of Hygiene and Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, Mar 10, 1997. “Update on NIDA's Imaging Studies of Substance Abuse.” Am. Soc. Addiction Medicine 28th Annual Medical Scientific Conference, San Diego, CA, Apr 17-20, 1997. "Neurobiology of Addiction: What's Craving Got to Do with It?" Med. Univ. SC, Charleston, SC May 26-27, 1997. Grand Rounds: "Img. Studies in Substance Abusers." Univ. MN Res. Training Retreat, Minneapolis, MN, May 31 - Jun 1, 1997. Lecture: “Drug Abuse”. Int. Business Communications Conf. "Nicotinic Acetylcholine Receptors", Wash., DC, Jul 24-25, 1997. "Development of Tracers for Noninvasive Imaging of Nicotinic Receptors in Brain." Int. Workshop on Drug Abuse Treatment Technology, Baltimore, MD, Aug 15-17, 1997. “New Approaches to Understanding Drug Abuse.” Am. Soc. Addiction Medicine, Wash., DC, Oct 24-25, 1997. “Neuroimaging: Assessing Sites of Action and their Implications." Am. Coll. Neuropsychopharmacology 36th Ann. Meeting, Kamuela, HI, Dec 8-12, 1997. “Cerebral metabolism during cue-elicited cocaine craving.” School of Hygiene and Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, Jan 12, 1998. “Update on NIDA's Imaging Studies of Substance Abuse.” International Conference on Substance Abuse, Budapest, Hungary, October 1998. “Brain imaging studies of opioid effects and the pathology of addiction.” NextMed: The End of Health Care, San Diego, CA, Jan 27-29, 1998. "What Can Brain Imaging Tell Us About the Mind and Soul?" Soc. Res. on Nicotine & Tobacco Symposium "Brain Imaging of Nicotine and Tobacco Smoking", New Orleans, LA, Mar 27-29, 1998. "Effects of Nicotine on Cerebral Glucose Metabolism." Department of Pharmacology & Experimental Therapeutics, Univ. Maryland Graduate Course, Baltimore, MD, Mar 31, 1998. "Drugs of Abuse." Department of Psychiatry, Nicotine Research Program, Duke University Medical Center and Health System, Durham, NC, Apr 7, 1998. “Brain Imaging Studies of Substance Abusers." College on Problems of Drug Dependence Inc., 60th Ann. Scientific Meeting, Scottsdale, AZ, Jun 13-18, 1998. Organizer satellite meeting: "Brain Imaging in Development of Medications for Drug Abuse." Lecture: "Imaging the Underlying Pathology of Drug Abuse." Am. Coll. Neuropsychopharmacology 37th Ann. Meeting, Las Croabas, Puerto Rico, Dec 14-18, 1998. Chaired panel entitled “Cerebral Responses to Nicotine: From the Perspectives of Neuroimaging and Receptor Dynamics”, presentation in study group, "Measurement of Alcohol and Other Drug Reactivity and Craving in the Animal and Human Lab.: Issues of Design, Ethics and Interpretation." The Neurobiology of Addiction Conference, UCLA, Los Angeles, CA, Jan 12-13, 1999. “Common Problems in Brain Imaging Studies of Drug Abuse." 32nd Annual Winter Conference on Brain Research, Snowmass, CO, Jan 22-30, 1999. In panel entitled “Novel Approaches to Smoking Cessation: Different Smokes for Different Folks." Interdisciplinary Substance Abuse Res. Ctr., Univ. Mich., Oct 20, 1999. “Brain Imaging and Drug Abuse”. Symposium on Substance Abuse, Johns Hopkins School of Hygiene and Public Health, Oct 21, 1999. “Brain Imaging Studies of Substance Abuse”. NIDA Symposium: LHPA Axis in Psychiatric Disorders, Sept 22, 1999, Bethesda, MD. “Cerebral Cortex in Drug Addicts, Imaging Studies.” 9

Curriculum Vitae - Edythe D. London, Ph.D.

6th Annual Conference on Behavior, Clinical Neuroscience, Substance Abuse & Culture. “Prefrontal Cortex and Drug Abuse”, Nov 4, 1999, Los Angeles, CA. Hawaii Reg. Methamphetamine Conf., Center for Substance Abuse Treatment, Dec 5-7, 1999, Honolulu. Session Co-Chair: “What Brain Imaging Research Tells Us About Methamphetamine Effect0s.” 6th Int. Stockholm/Springfield Symposium on Advances in Alzheimer Therapy, Apr 5-8, 2000, Stockholm. “Assessment of Nicotinic Receptors and Therapy for Alzheimer’s disease.” Am. Soc. Addiction Med., 31st Ann. Conf., lecture: “Imaging Nicotine Activity in the Brain”, Apr 14, 2000; lecture: “Neurobiology of Multiple Drug Abuse: Implications for Treatment”, Apr 15, 2000. Coll. Problems of Drug Dependence, Ann. Mtg., Jun 18, 2000. Co-chair and discussant in symposium: Antecedents, Consequences, and Treatment of Drug Dependence: A Cognitive Science Perspective. 11th World Cong. on Tobacco, Aug 8, 2000, Chicago IL. “Why are Nicotinic Receptors in the Brain?” Ctr. Substance Abuse Treatment. Sept 11, 2000, Portland, OR. “Brain Function in Addictive Disorders.” NIDA-Sponsored Conference: New Knowledge on Medications Development Workshop. Sept 28, 2000, Los Angeles, CA. “New Knowledge on Methamphetamine.” 7th Annual Conference on Behavioral, Clinical Neuroscience, Substance Abuse & Culture. Oct 19, 2000. “The Utility of PET in Studies of Substance Abuse” NIDA Conference, “Blending Clinical Practice and Research: Forging Partnerships to Enhance Drug Addiction Treatment”, Nov 1-2, 2000. “Drugs, the Brain, and Behavior.” Research Conference on The New Biopolitics, UCLA Center for Governance, UCLA Communication Studies Program. “Addiction: A Disease of Brain Function”, Nov 18, 2000. Women Professionals Panel, Women’s Leadership conference, Dept. Humanities, Sciences and Social Sciences, UCLA, Nov 18, 2000. Yale Univ. Sch. Med., Transdisciplinary Tobacco Res. Ctr., Dec 6, 2000, “Neuroimaging of Addictive Disease.” 4th Conf. on Pain Management and Chemical Dependency, Wash, DC, Dec 8, 2000. “Neuroimaging of Addictive Disease.” Am. Coll. Neuropsychopharmacology 40th Ann. Meeting, San Juan PR, Dec 14-18, 2000. Chaired panels: “Addiction as a Disease of the Orbitofrontal Cortex,” “Effects of Nicotine and Smoking on Brain Function: Imaging Studies”; lecture: “Effects of Nicotine and Smoking on Cognitive Activation: an fMRI Study.” Winter Conference on Brain Research, Steamboat Springs, AZ, Jan 23rd, 2001. Panel Discussion: “The Orbitofrontal Cortex and the Addictions: Neuroimaging Studies.” Los Angeles Psychoanalytic Institute Neuroscience Lecture Series, Los Angeles, CA Mar 16th, 2001. “Imaging Brain Dysfunction in Substance Abuse.” Am. Psychiatric Association, Annual Meeting. Special lecture (Frontiers in Neuroscience), “Imaging Brain Dysfunction in Substance Abuse”, May 8, 2001, New Orleans, LA. Am. Soc. Addiction Medicine Conference. NIDA Panel, “Alteration of motivational circuitry in brain by drugs of abuse,” Apr 20, 2001, Los Angeles, CA. ONDCP International Technology Symposium. “Development of a Molecular Imaging Laboratory at the Sepulveda VA Vervet Research Center”, Jun 27, 2001, San Diego, CA. American Psychological Assoc., 109th Convention. Lecture: “Structural Clinical Neuroimaging and the Clinical Neurosciences.” Discussant of symposium “Integrating Neuroimaging and Neuropsychology – An Interdisciplinary Approach to Substance Abuse,” Aug 25, 2001. Psychiatry Grand Rounds. Cedars-Sinai Health Center, “The High Road: Brain Imaging of Drug Abuse”, Oct 18, 2001, Los Angeles, CA. California Soc. Addiction Medicine. Addiction Medicine: State of the Art 2001 Conference, Oct 19, 2001, Marina del Rey, CA. “New Approaches to Neuroimaging of Drug Abuse Disorders.” th 7 Ann. Duke Nicotine Research Conference, “Nicotine’s Effect in Brain: Receptor Binding and Functional Assays.” Nov 8, 2001, Durham NC. An American Tragedy: The War on Drugs, sponsored by H.A. Schneiderman Memorial Bioethics Lecture Series and the Univ. of Calif., Irvine, “Neuroimaging Studies of Drug Abuse”, Nov 19, 2001. 10

Curriculum Vitae - Edythe D. London, Ph.D.

West Coast College of Biological Psychiatry, “Neuroimaging of Brain Function: Examples from Addictive Disorders”, April 19, 2002, Santa Monica, CA. XXIII CINP Cong., “Regional Cerebral Metabolism in Meth. Abusers”, June 25, 2002, Montreal, CA. American Psychiatric Assoc. symposium, “Circuitry of Failed Cognitive Strategies in Addiction”, Lecture: Brain Metabolism during Early Abstinence from Meth. Abuse” May 22, 2002, Phila., PA. 2002 ONDCP Demand Reduction Technology Symposium, July 8-10, 2002, Cambridge, MA. Lecture: “Methamphetamine Abuse: Brain Imaging to Tailor Treatment.” World Psychiat. Assoc. “Brain Imaging: Nicotine & Drugs of Abuse”, Aug. 24 – 29, 2002, Yokohama, Japan. CA Soc. Addiction Medicine, “Brain Function and Drug Abuse: Can Research Inform Treatment?” Oct 10, 2002, Newport Beach, CA. Annual Conference on Behavior, Clinical Neuroscience, Substance Abuse and Culture. “Brain Imaging & Co-Occurring Mental Disorders”, Oct 24 2002, Los Angeles, CA. National Conference on Tobacco or Health. Participated in symposium session CESS-178. “Neurobiology of Nicotine Addiction”, Nov 20, 2002, San Francisco, CA. UCLA Extension Course. Out of Our Minds: Brain Chemistry, Memory, Addictions, Sex, & Mood. “Addictive Drugs – Addictive Behavior”, Nov 16, 2002, Los Angeles, CA. nd 2 Annual Co-Occurring Disorders Conference: “Imaging the Brain: Seeing the Impact of Addiction” sponsored by LA County Dept. Alcohol & Drug Programs, June 2, 2003, Long Beach, CA. 2003 Imaging and the Brain Inst., Evergreen State College, Keynote Address: “Seeing Inside the Brain of an Addict: Why Some Take the High Road and What Happens When They Do.” Olympia, WA, July 10, 2003. th 10 Annual Conference: Behavior, Clinical Neuroscience, Substance Abuse and Culture: Lecture: “Brain Imaging and Co-occurring Mental Disorders.” Los Angeles, CA, Oct 23, 2003. th 8 Annual Investigator Meeting, Tobacco-Related Disease Research Program, University of California: “Mapping the Effects of Nicotine in the Brain by Noninvasive Imaging." San Diego, CA, Dec 3, 2003. Am. Coll Neuropsychopharmacology Annual Meeting: “Neural Substrates of Dysphoric Mood in Addition: Targets of Medications for Substance Abuse Disorders.” San Juan, PR, Dec 6-11, 2003. CA Addiction Training & Educ. Series: “METH, Behavior & Brain Imaging.” Mar. 30, 2004, Pasadena, CA. Univ. South FL, Excellence in Research Series: “Brain Imaging & Drugs of Abuse.” Apr. 28, 2004, Tampa, FL. MIRECC Seminar: "Brain Imaging Studies of Substance Abuse." May 26, 2004, VA Hosp., L.A., CA. American Psychological Assoc. 112th Convention, symposium: “Potential Predictors of Medication Efficacy from Human Laboratory Studies”, Honolulu, HI, July 28 – Aug. 1, 2004. Addiction Clinic, UCLA: “Substance Abuse: Predicting Treatment Efficacy from Human Brain Imaging.” Sept. 28, 2004, Los Angeles, CA. 3rd Charité Conference, Psychiatric Research: Emotional Neuroscience: “Brain Imaging Studies of Substance Dependency”, Berlin, Germany, October 3, 2004. UCLA Neuropsychiatric Institute and Department of Psychiatry and Biobehavioral Sciences Grand Rounds: “Imaging Cortical-Limbic Dysregulation in Substance Abuse.” Dec. 21, 2004, LA, CA. NIH/NIDA Methamphetamine Research Meeting “Imaging Methamphetamine Dependence; Phenotype of Corticolimbic Dysregulation.” March 9-10, 2005, Los Angeles, CA. Mount Sinai School of Medicine Grand Rounds “Methamphetamine Dependence: Imaging Corticolimbic Dysregulation.” March 29, 2005, New York, NY. Veterans Administration Greater L.A. Healthcare System Grand Rounds “Imaging Methamphetamine Dependence: Phenotype of Corticolimbic Dysregulation.” Apr. 21, 2005, Los Angeles, CA. Canadian Soc. Addiction Medicine, 17th Ann. Sci. Conf., Keynote Address: “Brain Imaging Studies of Methamphetamine Dependence.” Oct. 29, 2005, Vancouver, BC, Canada. Western Conference on Addictions: Improving Treatment with Scientific Knowledge: “Understanding Methamphetamine Dependence through Brain Imaging.” Nov. 11, 2005, Universal City, CA. Philip Morris External Research Program Symposium. “Cognitive Deficits, Nicotine Dependence, and the Effects of Smoking.” Dec. 6, 2005, Chantilly, VA. 11

Curriculum Vitae - Edythe D. London, Ph.D.

ACNP – JSNP Joint Symposium “Brain Imaging Reveals Corticolimbic Dysregulation in Methamphetamine Abusers” December 11 – 15, 2005, Waikoloa, Hawaii. Univ. Texas Southwestern Medical Center, Grand Rounds. “Methamphetamine Dependence: Corticolimbic Dysregulation and Loss of Inhibitory Control.” February 8, 2006, Dallas, TX. Natl. Conf. on Dual Diagnosis: Integrating Neurobiological, Psychiatric and Social Systems Perspectives on Co-occurring Substance Use Disorders and Mental Illness. “Methamphetamine and the Brain: A Problem of Inhibitory Control.” March 3, 2006. Indianapolis, IN. 2nd Annual Drug Abuse Research Symposium. Keynote speech: “Methamphetamine and the Brain: A Problem of Inhibitory Control. Charles R. Drew Univ. Med. and Science, Aug. 10, 2006. LA, CA. Addiction Neuroscience Network Australia: Developing a Research Strategy to Explore the Addicted Brain, Keynote speech: “Why do some people become addicts?” 9/8/2006. Hamilton Island, Queensland, AU. Mount Sinai School of Medicine, Dept. Psychiatry Grand Rounds, “Methamphetamine Abuse and “Topdown” Control”, Jan. 16, 2007, New York, NY. University of Miami, Sch. Med., Dept. Psychiatry Grand Rounds, “Methamphetamine Abuse and Loss of “Top-down” Control”, Feb. 2, 2007, Miami, FL. AAAS Symposium: “Addiction and the Brain: Are We Hard-Wired To Abuse Drugs?” Lecture: Methamphetamine and the Brain: A problem of Inhibitory Control.” Feb 16, 2007, San Francisco, CA. Beth Israel Medical Center, Psychiatry Grand Rounds, “Impaired Inhibitory Control in Stimulant Dependence: Neural Basis and Treatment”, Feb. 22, 2007, New York, NY. UCLA Symposium, Contemporary Perspectives in Treatment Development: Cognitive control in Childhood Disorders, “Probing Congnitive control and Related Processes In Vivo.” March 9, 2007, Los Angeles, CA. Univ. Michigan, Substance Abuse Research Center, “Methamphetamine and the Brain: “A Problem of Inhibitory Control.” April 25, 2007, Ann Arbor, MI. Joint meeting: Assoc. Mol. Imaging/Radiological Soc. NA/Soc. Nuclear Medicine/Soc. Molecular Imaging Pre-conferrence Symposium, “Elucidating the Neurobiology of Addiction.” Sept. 7, 2007, Providence, RI. European Society for Research on Nicotine and Tobacco, Symposium Lecture: “Neuroimaging in Tobacco and Nicotine Dependence: Current Status and Future Developments” Oct. 6, 2007, Madrid, Spain. Nicotinic Acetylcholine Receptors as Therapeutic Targets, Satellite meeting to Soc. Neurosci., “Imaging Approaches to Understanding the Biology of Nicotine Dependence.” Nov. 2, 2007, San Diego CA. Societa’ Italiana Tossicodipendenze, Preconference: Pussioni, Motivazioni e Liberto Arbitrio: “Dysfunction of the Prefrontal Cortex, Response Inhibition and Drug Addiction.” Nov. 26, 2007. Rome, Italy. Winter Conf. Brain Res.: “Translational Research in METH Dependence.” Jan., 2008. Snowbird, UT. Department of Psychiatry, University of Dresden: “Dysfunction of the Prefrontal Cortex, Response Inhibition and Drug Addiction.” April 8, 2008. Dresden, Germany. Am. Coll. Neuropsychopharmacology, “Prefrontal Cortical Deficits Underlie Impaired Inhibitory Control in Methamphetamine Abusers,” Dec. 11, 2008. Scottsdale, AZ. American Soc. Pharmacology and Experimental Therapeutics, Ray Fulller Symposium, AAAS meeting, “Smoking and Behavior: Brain Imaging Studies”, April 19, 2009, New Orleans. NIDA Mentoring Workshop, “Smoking & Behavior: Brain Imaging Studies”, June 19, 2009, Reno, NV. Soc. Res. Nicotine and Tobacco, annual meeting, Preclinical Science Plenary Lecture, “Imaging the Biology of Nicotine Dependence – from Mice to Men”, Feb. 26, 2010, Baltimore, MD. Dept. Psychiatry, Yale University, “Imaging the Biology of Nicotine Dependence – from Mice to Men”, March 26, 2010, New Haven, CT. Grand Rounds UCLA, Dept. Psychiatry and Biobehavioral Sci., “Brain Imaging of Nicotine Dependence: From Mice to Men”, April 6, 2010, Los Angeles, CA. NIDA Conference, “Translational Research in METH Addiction,” “Structural & functional abnormalities in the brain-relationship to inhibitory control deficits in METH users”, July, 2010, Pray, MT. Minority Institutions' Drug Abuse Research Development Prog., Charles Drew Univ. Drug Abuse Res. Symp., “Imaging the Biology of Nicotine Dependence – from Mice to Men”, Los Angeles, CA, Aug. 12, 2010. 12

Curriculum Vitae - Edythe D. London, Ph.D.

2010 National Hispanic Science Network on Drug Abuse, “The Methamphetamine Problem: Identifying Therapeutic Targets through Brain Imaging.” October 1, 2010, New Orleans, LA. Univ. Penn., “Brain Imaging of Nicotine Dependence: From Mice to Men”, Nov. 18, 2010, Phila., PA. Coll. Problems Drug Dependence, Animals in Research Forum, Defending Self and Science from AnimalRights Terrorists. June 20, 2011, Hollywood, FL. Coll. Problems Drug Dependence, Symposium XI. Rethinking the effects of Methamphetamines: “Topdown control and aggression in methamphetamine users.” June 23, 2011, Hollywood, FL. Duke Institute of Brain Sciences, “Self-Control, Brain Imaging and Addiction”, July 26, 2011, Durham, NC. Nicotine Reduction: Establishing a Research Plan and Collaboration (sponsored by FDA, NIDA): “Methods to Measure Nicotine Effects Using Imaging.” Oct. 3, 2011, Bethesda, MD. Duke Nicotine Research Conference: "Cues of Addiction: Links to Brain Pathways of Self-control." Oct. 13, 2011, Durham, NC. Univ. MA Sch. Med., Dept. Psychiatry Grand Rounds, “Self-Control, Brain Imaging and Addiction”, Oct. 27, 2011, Worcester, MA. Veterans Administration Greater Los Angeles Health Center, Dept. Psychiatry grand rounds, “Neurobiology of Self-Control & Addiction.”, Oct. 27, 2011, Los Angeles, CA. Scripps Research Institute, “Self-Control, Brain Imaging and Addiction”, Jan. 18, 2012, La Jolla, CA. UCSD Dept Psychiatry Grand Rounds, “Self-Control, Brain Imaging and Addiction”, Jan. 26, 2012, San Diego, CA. BIBLIOGRAPHY (14,996 citations as of January, 2012; Avg 38.65 citations per year; h-index = 60.

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GG Buterbaugh, ED London (1977): Relationship between magnitude of electroshock stimulation and effects of digitoxigenin, pentylenetetrazol and brain monoamine reduction on electroshock convulsive thresholds. J. Neuropharmacology 16:617-623. ED London, G Buterbaugh (1978): Modification of electroshock convulsive responses and thresholds in neonatal rats following brain monoamine reduction. J. Pharmacol. Exp. Ther. 206:81-90. RS London, ED London, M Siegelbaum, P Goldstein (1978): The use of doxycycline in elective first trimester abortions. Southern Med. J. 71:672-673. RS London, D Solomon, ED London, D Strummer, J Bankoski, PP Nair (1978): Mammary dysplasia: Clinical response and urinary excretion of 11-deoxy, 17-ketosteroids and pregnanediol following α-tocopherol therapy. Breast J.: Diseases of the Breast 4:19-22. ED London, LW Harris, WC Heyl, JT Coyle (1978): Effect of 2-dimethylaminoethanol in kainatelesioned rat striatum: Anomaly in the radioenzymatic assay of acetylcholine. Commun. Psychopharmacol. 2:357-364. ED London, JT Coyle (1978): Pharmacological augmentation of acetylcholine levels in kainatelesioned rat striatum. Biochem. Pharmacol. 27:2962-2965. 3

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ED London, JT Coyle (1979): Cooperative interactions at [3H]-kainic acid binding sites in rat and human cerebellum. Eur. J. Pharmacol. 56:287-290.

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13

Curriculum Vitae - Edythe D. London, Ph.D.

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FJ Vocci Jr., JM Rhody, ED London, GG Buterbaugh (1980): Regional brain [3H]-digitoxigenin and monoamine content during the development of convulsions produced by systemic digitoxigenin. Res. Commun. Mol. Pathol. Pharmacol. 29:251-263. ED London, HI Yamamura, ED Bird, JT Coyle (1981): Decreased receptor-binding sites for kainic acid in brains of patients with Huntington's disease. Biol. Psychiatry 16:155-162. M Ohata, U Sundaram, WR Fredericks, ED London, SI Rapoport (1981): Regional cerebral blood flow during development and ageing of the rat brain. Brain l04: 319-332.

* ED London, SM Nespor, M Ohata, SI Rapoport (1981): Local cerebral glucose utilization during development and aging of the Fischer-344 rat. J. Neurochem. 37:217-221 [96 citations].

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* DK Ingram, ED London, CL Goodrick (1981): Age and neurochemical correlates of radial maze performance in rats. Neurobiol. Aging 2:41-47 [187 citations]. D Dow-Edwards, M Dam, JM Peterson, SI Rapoport, ED London (1981): Effect of oxotremorine on local cerebral glucose utilization in motor system regions of the rat brain. Brain Res. 226:281-289. JM Palacios, MJ Kuhar, SI Rapoport, ED London (1981): Increases and decreases in local cerebral glucose utilization in response to GABA agonists. Eur. J. Pharmacol. 71:333-336. SI Rapoport, ED London, WR Fredericks, DL Dow-Edwards, PR Mahone (1981): Altered cerebral glucose utilization following blood-brain barrier opening by hypertonicity or hypertension. Exp. Neurol. 74:519-529. DK Ingram, ED London, MA Reynolds, SB Waller, and CL Goodrick (1981): Differential effects of age on motor performance in two mouse strains. Neurobiol. Aging 2:221-227 [72 citations]. NL Shinowara, ED London, SI Rapoport (1982): Changes in retinal morphology and glucose utilization in aging albino rats. Exp Eye Res. 34:517-530. SI Rapoport, ED London, H Takei (1982): Brain metabolism and blood flow during development and aging of the Fischer-344 rat. Exp. Brain Res. Suppl. 5:86-101. M Partanen, SI Rapoport, ED London (1982): Glucose utilization in sympathetic ganglia of male Fischer-344 rats at different ages. J. Auton. Neurosci. 5:391-398. DH Corddry, SI Rapoport, ED London (1982): No effect of hyperketonemia on local cerebral glucose utilization in conscious rats. J. Neurochem. 38:1637-1641. ED London, SB Waller, FJ Vocci, GG Buterbaugh (1982): Age-dependent reduction in maximum electroshock convulsive threshold associated with decreased concentrations of brain monoamines. Pharmacol. Biochem. Behav. 16:441-447. JM Palacios, MJ Kuhar, SI Rapoport, ED London (1982): Effects of γ-aminobutyric acid agonist and antagonist drugs on local cerebral glucose utilization. J. Neurosci. 2:853-860. JM Thompson, ED London, JE Johnson (1982): Ultrastructural, functional and biochemical characteristics of mouse and human neuroblastoma cell lines. Neuroscience 7:1807-1815. M Dam, JK Wamsley, SI Rapoport, ED London (1982): Effect of oxotremorine on local glucose utilization in the rat cerebral cortex. J. Neurosci. 2:1072-1078.

* DK Ingram, ED London, MA Reynolds (1983): Circadian rhythmicity and sleep: Effects of aging in laboratory animals. Neurobiol. Aging 3:287-297 [66 citations]. M Dam, ED London (1983): Effects of cholinomimetics on glucose utilization in rat brain optic systems. Eur. J. Pharmacol. 87:137-140. H Takei, WR Fredericks, ED London, SI Rapoport (1983): Cerebral blood flow and oxidative metabolism in conscious Fischer-344 rats at different ages. J. Neurochem. 40:801-805. 14

Curriculum Vitae - Edythe D. London, Ph.D.

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AS Kimes, D Sweeney, ED London, SI Rapoport (1983): Palmitate incorporation into different brain regions in the awake rat. Brain Res. 274:291-301. ED London, M Ohata, H Takei, AW French, SI Rapoport (1983): Regional cerebral metabolic rate for glucose in Beagle dogs of different ages. Neurobiol. Aging 4:121-126. MJ Ball, J Macgregor, IM Fyfe, SI Rapoport, ED London (1983): Paucity of morphological changes in the brains of aging Beagle dogs: Further evidence that Alzheimer lesions are unique for primate central nervous system. Neurobiol. Aging 4:127-131.

* R Duara, RA Margolin, EA Robertson-Tchabo, ED London, M Schwartz, JW Renfrew, BJ Koziarz, C Grady, M Sundaram, AM Moore, DH Ingvar, L Sokoloff, H Weingartner, RA Kessler, R Manning, R Channing, N Cutler, SI Rapoport (1983): Cerebral glucose utilization, as measured with positron emission tomography, in 21 resting healthy men between the ages of 21 and 83 years. Brain 106:761-775 [205 citations]. SB Waller, DK Ingram, MA Reynolds, ED London (1983): Age and strain comparisons of neurotransmitter synthetic enzyme activities in the mouse. J. Neurochem. 41:1421-1428. DK Ingram, ED London, SB Waller, MA Reynolds (1983): Age-dependent correlation of motor performance with neurotransmitter synthetic enzyme activities in mice. Behav. Neural Biol. 39:284-298. SB Waller, ED London (1983): Age differences in choline acetyltransferase activities and muscarinic receptor binding in brain regions of C57BL/6J mice. Exp. Gerontol. 18:419-425. M Dam, ED London (1984): Glucose utilization in the Papez circuit: Effects of oxotremorine and scopolamine. Brain Res. 295:137-144. P Helén, ED London (1984): Muscimol-scopolamine interactions in the rat brain: A study with 2deoxy-D[1-14C]glucose. J. Neurosci. 4:1405-1413.

* ED London, M McKinney, M Dam, A Ellis, JT Coyle (1984): Decreased cortical glucose utilization after ibotenate lesion of rat ventromedial globus pallidus. J. Cereb. Blood Flow Metab. 4:381-390 [72 citations].

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* ED London, SB Waller, JK Wamsley (1985): Autoradiographic localization of [3H]-nicotine binding sites in the rat brain. Neurosci. Lett. 53:179-184 [98 citations]. D Bernstein, DS Olton, DK Ingram, SB Waller, M Reynolds, ED London (1985): Radial maze performance in young and aged mice: Neurochemical correlates. Pharmacol. Biochem. Behav. 22:301-307. ED London, RJ Connolly, M Szikszay, JK Wamsley (1985): Distribution of cerebral metabolic effects of nicotine in the rat. Eur. J. Pharmacol. 110:391-392. AM Lowy, DK Ingram, DS Olton, SB Waller, MA Reynolds, ED London (1985): Discrimination learning requiring different memory components in rats: Age and neurochemical comparisons. Behav. Neurosci. 99:638-651. ED London, SB Waller, AT Ellis, DK Ingram (1985): Effects of intermittent feeding on neurochemical markers in aging rat brain. Neurobiol. Aging 6:199-204. M Partanen, SB Waller, ED London, A Hervonen, SI Rapoport (1985): Indices of neurotransmitter synthesis and release in aging sympathetic nervous system. Neurobiol. Aging 6:227-232. RJ Fanelli, CM Dersch, ED London (1985): Effects of subchronic morphine on choline acetyltransferase and muscarinic binding in the rat brain. Res. Comm. Subst. Abuse 6:189-192. ED London, RC Walovitch (1985): Le metabolisme cerebral du glucose chez les rongeurs ages: Action de la co-dergocrine. J. Pharmacol. 16: Suppl. III: 85-97.

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ED London, RC Walovitch (1985): Cerebral glucose metabolism in aging rodents: Effects of codergocrine. J. Pharmacol. 16: Suppl. III (English Edition): 73-84.

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* ED London, G Wilkerson, SR Goldberg, ME Risner (1986): Effects of l-cocaine on local cerebral

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glucose utilization in the rat. Neurosci. Lett. 68:73-78 [62 citations]. M Szikszay, FR Snyder, ED London (1986): Effects of diltiazem on morphine-induced respiratory decline. J. Pharm. Pharmacol. 38:625-627. M Szikszay, FR Snyder, ED London (1986): Interactions between verapamil and morphine on physiological parameters in rats. J. Pharmacol. Exp. Ther. 238:192-197. ED London, RA Margolin, R Duara, H Holloway, E Robertson-Tchabo, N Cutler, SI Rapoport (1986): Effects of fasting on ketone body concentrations in healthy men of different ages. J. Gerontol. 41:599-604. SB Waller, M Ball, M Reynolds, ED London (1986): Muscarinic binding and choline acetyltransferase in postmortem brains of demented patients. Can. J. Neurol. Sci. 13: Suppl. IV: 528-532. M Selmanoff, RC Walovitch, GE Walker, ED London (1987): Effects of hyperprolactinemia on plasma prolactin and glucose and on local cerebral glucose utilization. J. Neurochem. 48:94-101. RC Walovitch, DK Ingram, EL Spangler, ED London (1987): Co-dergocrine, cerebral glucose utilization and maze performance in middle-aged rats. Pharmacol. Biochem. Behav. 26:85-101. JE Johnson Jr., JJ White Jr., RC Walovitch, ED London (1987): Effects of morphine on rat kidney glomerular podocytes: A scanning electron microscopic study. Drug Alcohol Depend. 19:249-257. RF Fanelli, M Szikszay, DR Jasinski, ED London (1987): Differential effects of mu and kappa opioid analgesics on cerebral glucose utilization in the rat. Brain Res. 422:257-266. C Ori, T-P Su, AD Weissman, ED London (1987): Extraordinary postmortem stability of kappa opioid receptors in guinea pig brain. J. Pharm. Pharmacol. 39:951-954.

* AD Weissman, M Dam, ED London (1987): Alterations in local cerebral glucose utilization induced by phencyclidine. Brain Res. 435:29-40 [53 citations]. P Wise, R Walovitch, I Cohen, N Weiland, E London (1987): Diurnal rhythmicity and hypothalamic deficits in glucose utilization in aged ovariectomized rats. J. Neurosci. 7:3469-3473. ED London, AS Kimes, RJ Fanelli (1987): Cerebral metabolic effects of morphine in the rat. Substance Abuse 8:43-52.

* T-P Su, ED London, JH Jaffe (1988): Steroid binding at sigma receptors suggests a link between endocrine, nervous and immune systems. Science 240:219-221. T-P Su, ED London, JH Jaffe (1989): Steroid binding at σ "opioid" receptor: Response to a technical comment. Science 246:1635-1638 [393 citations]. ED London, M Dam, RJ Fanelli (1988): Nicotine enhances cerebral glucose utilization in central components of the rat visual system. Brain Res. Bull. 20:381-385. T-P Su, SE Schell, FY Ford-Rice, ED London (1988): Correlation of inhibitory potencies of putative antagonists for σ receptors in brain and spleen. Eur. J. Pharmacol. 148:467-470. M Szikszay, ED London (1988): Effects of subacute capsaicin treatment on local cerebral glucose utilization in the rat. Neuroscience 25:917-923.

* PM Wise, IR Cohen, NG Weiland, ED London (1988): Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus. Proc. Natl. Acad. Sci. USA. 85:5305-5309 [82 citations]. J Bell, A Kimes, E London (1988): Increased glucose utilization in superficial layers of the rat spinal dorsal horn during precipitated morphine withdrawal. Pharmacol. Biochem. Behav. 150:171-174. 16

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68.

* ED London, RJ Connolly, M Szikszay, JK Wamsley, M Dam (1988): Effects of nicotine on local cerebral glucose utilization in the rat. J. Neurosci. 8:3920-3928 [88 citations].

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* AD Weissman, T-P Su, JC Hedreen, ED London (1988): Sigma receptors in post-mortem human brains. J. Pharmacol. Exp. Ther. 247:29-33 [84 citations]. ED London (1989): The effects of drug abuse on glucose metabolism. J. Neuropsychiatry Clin. Neurosci. 1: Suppl. I: S30-S36. RJ Fanelli, RC Walovitch, DR Jasinski, ED London (1989): Naloxone fails to alter local cerebral glucose utilization in the rat. Pharmacol. Biochem. Behav. 31:481-485. AS Kimes, ED London (1989): Glucose utilization in the rat brain during chronic morphine treatment and naloxone-precipitated morphine withdrawal. J. Pharmacol. Exp. Ther. 248:538-545.

* EP Broussolle, DF Wong, RJ Fanelli, ED London (1989): In vivo specific binding of [3H]lnicotine in the mouse brain. Life Sci. 44:1123-1132 [50 citations]. JL Cadet, A della Puppa, ED London (1989): Involvement of nigrotecto-reticulospinal pathways in the iminodipropionitrile (IDPN) model of spasmodic dyskinesias: a 2-deoxyglucose study in the rat. Brain Res. 484:57-64. C Ori, F Ford-Rice, ED London (1989): Effects of nitrous oxide and halothane on mu and kappa opioid receptors in guinea-pig brain. Anesthesiology 70:541-544. MD Majewska, S Parameswaran, T Vu, ED London (1989): Divergent ontogeny of sigma and phencyclidine binding sites in the rat brain. Dev. Brain Res. 47:13-18. A Weissman, K Marquis, J Moreton, ED London (1989): Effects of self-administered phencyclidine on regional brain uptake of 2-deoxy-D-[1-14C]-glucose in brain. Neuropharmacology 28:575-583. SB Waller, ED London (1989): Choline acetyltransferase activity and muscarinic binding in brain regions of aging Fischer-344 rats. Neurochemistry Int. 14: 483-490. SE Moroi-Fetters, RF Mervis, ED London, DK Ingram (1989): Dietary restriction suppresses agerelated changes in dendritic spines. Neurobiol. Aging 10:317-322.

* ED London, MJ Ball, SB Waller (1989): Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia. Neurochem. Res. 14: 745-750 [85 citations]. G Wilkerson, ED London (1989): Effects of methylenedioxymethamphetamine on local cerebral glucose utilization in the rat. Neuropharmacology 28:1129-1138. A della Puppa, F Ford-Rice, F Snyder, E Cone, ED London (1989): Time course of verapamil interacttion with morphine effects on physiological parameters in rats. J. Pharm. Pharmacol. 41:617-623. ED London, RA Margolin, DF Wong, JM Links, ND LaFrance, NG Cascella, E Broussolle, HN Wagner, FR Snyder, DR Jasinski (1989): Cerebral glucose utilization in human heroin addicts: Case reports from a positron emission tomographic study. Res. Comm. Subst. Abuse 10:141-144. A della Puppa, ED London (1989): Cerebral metabolic effects of sigma ligands in the rat. Brain Res. 505:283-290. H Takayama, MD Majewska, ED London (1989): Interactions of noncompetitive inhibitors with nicotinic receptors in the rat brain. J. Pharmacol. Exp. Ther. 253:1083-1089. LP Raymon, Kimes AS, Tabakoff B, ED London (1989): SIDA et troubles du sommeil: effect du gp120 sur le metabolisme cerebral du glucose. C.R. Soc. Biol. 183:407-418. TH Vu, AD Weissman, ED London (1990): Pharmacological characteristics and distributions of sigma and phencyclidine binding sites in the animal kingdom. J. Neurochem. 54:598-604. 17

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88.

* ED London, EPM Broussolle, JM Links, DF Wong, NG Cascella, RF Dannals, M Sano, R

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Herning, FR Snyder, LR Rippetoe, TJK Toung, JH Jaffe, HN Wagner Jr. (1990): Morphine-induced metabolic changes in human brain. Studies with positron emission tomography and [18F]fluorodeoxyglucose. Arch. Gen. Psychiatry 47:73-81 [106 citations]. ED London, G Wilkerson, C Ori, AS Kimes (1990): Central action of psychomotor stimulants on glucose utilization in extrapyramidal motor areas of the rat brain. Brain Res. 512:155-158. AS Kimes, JA Bell, ED London (1990): Clonidine attenuates increased brain glucose metabolism during naloxone-precipitated morphine withdrawal. Neuroscience 34:633-644.

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* ED London, N Cascella, DF Wong, RL Phillips, R Dannals, J Links, R Herning, R Grayson, J Jaffe, H Wagner (1990): Cocaine-induced reduction of glucose utilization in human brain. A study using positron emission tomography and [18F]fluorodeoxyglucose. Arch. Gen. Psychiatry 47:567-574 [214 citations].

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* JE Henningfield, ED London, NL Benowitz (1990): Arterial-venous differences in plasma

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concentrations of nicotine after cigarette smoking. JAMA 263:2049-2050 [63 citations]. CR Mantione, S Demirgören, ED London (1990): Specific binding of [3H]-spermidine to membranes of rat brain. Eur. J. Pharmacol. 180:393-394.

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* MD Majewska, S Demirgören, C Spivak, ED London (1990): The neurosteroid dehydro-

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epiandrosterone sulfate is an allosteric antagonist of the GABAA receptor. Brain Res. 526:143-146 [405 citations]. ED London, RJ Fanelli, AS Kimes, RL Moses (1990): Effects of chronic nicotine on cerebral glucose utilization in the rat. Brain Res. 520:208-214. AD Weissman, EP Broussolle, ED London (1990): In vivo binding of [3H]d-N-allylnormetazocine and [3H]-haloperidol to sigma receptors in the mouse brain. J. Chem. Neuroanat. 3:347-354.

* MD Majewska, S Dermirgören, ED London (1990): Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor. Eur. J. Pharmacol. 189:307-315 [92 citations]. RL Phillips, ED London, JM Links, NG Cascella (1990): Program for PET image alignment: Effects on calculated differences in cerebral metabolic rates for glucose. J. Nucl. Med. 31:2052-2057.

* A Weissman, M Casanova, J Kleinman, ED London, EB de Souza (1990): Selective loss of cerebral cortical sigma, but not PCP binding sites in schizophrenia. Biol. Psychiatry 29:41-54 [116 citations].

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* MD Majewska, JA Bell, ED London (1990): Regulation of the NMDA receptor by redox phenomena: Inhibitory role of ascorbate. Brain Res. 537:328-332 [99 citations]. SR Cohen, AS Kimes, ED London (1991): Morphine decreases cerebral glucose utilization in limbic and forebrain regions while pain has no effect. Neuropharmacology 30:125-134. AS Kimes, ED London, G Szabo, L Raymon, B Tabakoff (1991): Reduction of cerebral glucose utilization by the HIV envelope glycoprotein gp-120. Exp. Neurol. 112:224-228.

* X-Z Wu, JA Bell, CW Spivak, ED London, T-P Su (1991): Electrophysiological and binding studies on intact NCB-20 cells suggest presence of a low affinity sigma receptor. J. Pharmacol. Exp. Ther. 257: 351-359 [68 citations].

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* VL Dawson, TM Dawson, ED London, DS Bredt, SH Snyder (1991): Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA. 88: 6368-6371 [1,875 citations].

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NG Cascella, G Pearlson, DF Wong, EPM Broussolle, C Nagoshi, RA Margolin, ED London (1991): Effects of substance abuse on ventricular and sulcal measures assessed by computerized tomography. Brit. J. Psychiatry 159:217-221.

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* S Demirgören, MD Majewska, CE Spivak, ED London (1991): Receptor binding and electrophysiolo-

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gical effects of dehydroepiandrosterone sulfate, an antagonist of the GABAA receptor. Neuroscience 45:127-135 [181 citations]. AS Kimes, LR Raymon, LT Meltzer, T Heffner, ED London (1991): Cerebral metabolic effects of 8ethyl-7,8-dihydro-1,3,5-trimethyl-1H-imidazo-[1,2,-c]pyrazolo-[3,4-e]-pyrimidine, a potential antipsychotic drug. Drug Dev. Res 24:29-39. MJ Morgan, AS Kimes, ED London (1992): Possible roles for nitric oxide in AIDS and associated pathology. Med. Hypothesis 38:189-193. AS Kimes, WJ Smith, CJ Winchell, ED London (1992): Effects of morphine on the phenotypic expression of cell surface markers on murine lymphocytes. Life Sci. 51:807-815.

* DK Ingram, P Garofalo, EL Spangler, CR Mantione, I Odano, ED London (1992): Reduced density of NMDA receptors and increased sensitivity to dizocilpine-induced learning impairment in aged rats. Brain Res. 580:273-280 [54 citations]. AS Kimes, AA Wilson, U Scheffel, BG Campbell, ED London (1992): Radiosynthesis, cerebral distribution and binding of [125I]1-(p-iodophenyl-3-(1-adamantyl)guanidine ([125I]PIPAG), a ligand for sigma binding sites. J. Med. Chem. 35:4683-4689. A della Puppa, AS Kimes, ED London (1993): Dose-dependent effects of d-N-allylnormetazocine on regional cerebral metabolic rates for glucose. Brain Res. 603:38-46.

* K Hashimoto, ED London (1993): Further characterization of [3H]ifenprodil binding to σ receptors in rat brain. Eur. J. Pharmacol. 236:159-163 [65 citations].

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* JE Henningfield, JM Stapleton, NL Benowitz, RF Grayson, ED London (1993): Higher levels of

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nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend. 33:23-29 [290 citations]. MJ Morgan, NJ Cascella, JM Stapleton, RL Phillips, BCK Yung, DF Wong, EK Shaya, ED London (1993): Sensitivity to subjective effects of cocaine in drug abusers: Relation to cerebral ventricle size. Am. J. Psychiatry 150:1712-1717.

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* AS Kimes, DB Vaupel, ED London (1993): Attenuation of some signs of opioid withdrawal by

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inhibitors of nitric oxide synthase. Psychopharmacology 42:521-524 [74 citations]. DB Vaupel, WR Lange, ED London (1993): Effects of verapamil on morphine-induced euphoria, analgesia and respiratory depression in humans. J. Pharmacol. Exp. Ther. 267:1386-1394. K Hashimoto, CR Mantione, MR Spada, JL Neumeyer, ED London (1994): Further characterization of [3H]ifenprodil binding in rat brain. Eur. J. Pharmacol. 266:67-77. MC Ritz, CR Mantione, ED London (1994): Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology 114:47-52. TP O'Brien, CA Gleason, MD Jones Jr., EJ Cone, ED London, RJ Traystman (1994): Cerebral responses to single and multiple cocaine injections in newborn sheep. Pediatr. Res. 35:339-343. 19

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JE Flesher, U Scheffel, ED London, JJ Frost (1994): In vivo labeling of nicotinic cholinergic receptors in brain with [3H]cytisine. Life Sci. 54:1883-1890. SL Walsh, SF Gilson, DR Jasinski, JM Stapleton, RL Phillips, RF Dannals, J Schmidt, KL Preston, R Grayson, GE Bigelow, JT Sullivan, C Contoreggi, ED London (1994): Buprenorphine reduces cerebral glucose metabolism in polydrug abusers. Neuropsychopharmacology 10:157-170. RI Herning, BJ Glover, B Koeppl, RL Phillips, ED London (1994): Cocaine-induced increases in EEG alpha and beta activity: evidence for reduced cortical processing. Neuropsychopharmacology 11:1-9. RL Phillips, R Herning, ED London (1994): Morphine effects on the spontaneous electroencephalogram in polydrug abusers: Correlations with subjective self-reports. Neuropsychopharmacology 10:171-181. A Shimada, EL Spangler, ED London, D Ingram (1994): Spermidine potentiates dizocilpine-induced impairment of learning performance by rats in a 14-unit T-maze. Eur. J. Pharmacol. 263:293-300.

* DK Ingram, EL Spangler, SD Iijima, H Ikari, H Kuo, NH Greig, ED London (1994): Rodent models of memory dysfunction in Alzheimer's disease and normal aging: Moving beyond the cholinergic hypothesis. Life Sci. 55:2037-2049 [60 citations]. Hashimoto K, U Scheffel, ED London (1995): In vivo labeling of sigma receptors in mouse brain with [3H]4-phenyl-1-(4-phentylbutyl)piperidine. Synapse 20:85-90. K Hashimoto, ED London (1995): Interactions of erythro-ifenprodil, threo-ifenprodil, erythroiodoifenprodil and eliprodil with subtypes of σ receptors. Eur. J. Pharmacol. 273:307-310. ED London, U Scheffel, AS Kimes, KJ Kellar (1995): In vivo labeling of nicotinic acetylcholine receptors in brain with [3H]epibatidine. Eur. J. Pharmacol. 278:R1-R2.

* DB Vaupel, AS Kimes, ED London (1995): Comparison of 7-nitroindazole with other nitric oxide synthase inhibitors as attenuators of opioid withdrawal. Psychopharmacology 118:361-368 [54 citations].

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* JM Stapleton, MJ Morgan, RL Phillips, DF Wong, BCK Yung, EK Shaya, RF Dannals, X Liu, RL Grayson, ED London (1995): Cerebral glucose utilization in polysubstance abuse. Neuropsychopharmacology 13:21-31 [50 citations]. X Liu, RL Phillips, S Resnick, V Villemagne, D Wong, JM Stapleton, ED London (1995): Magnetic resonance imaging reveals no ventriculomegaly in polydrug abusers. Acta Neurol. Scand. 92:83-90. RL Phillips, C Chen, D Wong, ED London (1995): An improved method to calculate cerebral metabolic rates for glucose using PET. J. Nucl. Med. 36:1668-1679.

* DB Vaupel, AS Kimes, ED London (1995): Nitric oxide synthase inhibitors: Preclinical studies of potential use for treatment of opioid addiction. Neuropsychopharmacology 13:315-322 [76 citations]. JA Bell, C Beglan, ED London (1995): Interaction of ascorbic acid with the neurotoxic effects of NMDA and sodium nitroprusside. Life Sci. 58:367-371. H Takahashi, J Kirsch, K Hashimoto, ED London, R Koehler, R Traystman (1995): PPBP [4-phenyll-(4-phenylbutyl) piperidine], a potent sigma receptor ligand, decreases brain injury after transient focal ischemia in cats. Stroke 26:1676-1682. A Horti, Ravert HT, London ED, Dannals RF (1996): Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: (+/-)-exo-2-(2-[18F]fluoro-5-pyridyl-7-azabiocyclo[2.2.1]heptane. J. Label. Compds. Radiopharm. 38: 355-366. T Matsunaga, AG Mukhin, ED London (1996): Regionally distinct stoichiometry for N-methyl-Daspartate receptor domains in brain. Neuroreport 7:833-837. 20

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RD Kusztos, DK Ingram, EL Spangler, ED London (1996): Effects of aging and chronic nimodipine on hippocampal binding of [3H]CGS 19755. Neurobiol. Aging 17(3): 453-457.

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* S Grant, ED London, DB Newlin, VL Villemagne, X Liu, C Contoreggi, RL Phillips, AS Kimes,

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* JL Musachio, V Villemagne, U Scheffel, M Stathis, P Finley, A Horti, ED London, RF Dannals

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(1997): [125/123I]IPH: A radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors. Synapse 26:392-399 [57 citations]. JM Stapleton, MJ Morgan, X Liu, BC-K Yung, RL Phillips, DF Wong, EK Shaya, RF Dannals, ED London (1997): Cerebral glucose utilization is reduced in second test session. J. Cereb. Blood Flow Metab. 17:704-712.

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* MI Davila-Garcia, JL Musachio, DC Perry, Y Xiao, A Horti, ED London, RF Dannals, KJ Kellar

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(1997): [125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors. J. Pharmacol. Exp. Ther. 282:445-451 [80 citations]. RL Phillips, ED London (1997): Simplified calculation of MRglc using PET. J. Nucl. Med. 38:1334.

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* A Horti, U Scheffel, M Stathis, P Finley, HT Ravert, ED London, RF Dannals (1997): Fluorine-18-

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FPH for PET imaging of nicotinic acetylcholine receptors. J. Nucl. Med. 38:1260-1265 [55 citations]. A Mukhin, ES Kovaleva, ED London (1997): Two affinity states of NMDA recognition sites: Modulation by cations. J. Pharmacol. Exp. Ther. 282:945-954. A Shimada, A Mukhin, DK Ingram, ED London (1997). N-methyl-D-aspartate receptor binding in brains of rats at different ages. Neurobiol. Aging 18:329-33. E Koylu, S Demirgören, ED London, S Pogun (1997). Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain. Life Sci. 61:PL185-190. H Takahashi, RJ Traystman, K Hashimoto, ED London, JR Kirsch (1997): Postischemic brain injury is affected stereospecifically by pentazocine in rats. Anesth. Analg. 85:353-357. 21

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X Liu, JL Musachio, HN Wagner, Jr., T Mochizuki, RF Dannals, ED London (1997). External monitoring of cerebral nicotinic acetylcholine receptors in living mice. Synapse 24:378-380. * VL Villemagne, A Horti, U Scheffel, HT Ravert, P Finley, D Clough, ED London, HN Wagner Jr., RF Dannals (1997): Imaging nicotinic acetylcholine receptors with fluorine-18-FPH, an epibatidine analog. J. Nucl. Med. 38:1737-1741 [61 citations].

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* NJ Alkayed, I Harukuni, AS Kimes, ED London, RJ Traystman, PD Hurn (1998): Gender-linked brain injury in experimental stroke. Stroke 29:159-166 [479 citations].

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* X Liu, JA Matochik, JL Cadet, ED London (1998): Smaller volume of prefrontal lobe in polysubstance abusers: A magnetic resonance imaging study. Neuropsychopharmacology 18:243-252 [119 citations].

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DK Ingram, EL Spangler, RC Meyer, ED London (1998): Learning in a 14-unit T-maze is impaired in rats following systemic treatment with Nω-nitro-L-arginine. Neurobiol. Aging 341:1-9.

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* RC Meyer, ED Spangler, N Patel, ED London, DK Ingram (1998): Impaired learning in a 14-unit

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* AG Horti, AO Koren, HT Ravert, JL Musachio, WB Mathews, ED London, RF Dannals (1998): Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: 2-[18F]fluoro-3-(2(S)azetidinylmethoxy)pyridine (2-[18F]A-85380). J. Labelled Compd. Radiopharm. XLI: 309-318 [60 citations]. X Liu, DB Vaupel, S Grant, ED London (1998): Effect of cocaine-related environmental stimuli on the spontaneous electroencephalogram in polydrug abusers. Neuropsychopharmacology 19:10-17. M Kassiou; UA Scheffel, HT Ravert, WB Mathews, JL Musachio; ED London, RF Dannals (1998): Pharmacological evaluation of [11C]A-84543: an enantio-selective ligand for in vivo studies of neuronal nicotinic acetylcholine receptors. Life Sci. 63:PL13-8.

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* K Bolla, JL Cadet, ED London (1998): The neuropsychiatry of chronic cocaine abuse. J.

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* AO Koren, AG Horti, AG Mukhin, D Gündisch, AS Kimes, RF Dannals, ED London (1998): 2-, 5- and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: Synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. J. Med. Chem. 41:3690-3698 [120 citations].

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* AG Horti, U Scheffel, AO Koren, HT Ravert, WB Mathews, JL Musachio, PA Finley, ED

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MR Costello, MA Mandelkern, S Shoptaw, S Shulenberger, SK Baker, AL Abrams, C Xia, ED London, AL Brody (2010): Effects of treatment for tobacco dependence on resting cerebral glucose metabolism. Neuropsychopharmacology 35(3): 605-612. M Ernst, DA Luckenbaugh, ET Moolchan, VA Temple, J Jenness, KE Korelitz, ED London, A Kimes (2010): Decision-making and facial emotion recognition as predictors of substance-use initiation among adolescents. Addict. Behav. 35 (3):286-289. AL Brody, ED London, RE Olmstead, Z Allen-Martinez, S Shulenberger, MR Costello, D Scheibal, J Farahi, S Shoptaw, MA Mandelkern (2010): Smoking-induced change in intrasynaptic dopamine concentration: Effect of treatment for tobacco dependence. Psychiat. Res.- Neuroim. 183:218-224. A Azizian, L Nestor, D Payer, JR Monterosso, AL Brody, ED London (2010): Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology 35(3): 775-782. SL Simon, AC Dean, X Cordova, JR Monterosso, ED London (2010): Methamphetamine dependence and neuropsychological functioning: Evaluating change during early abstinence. J. Stud. Alcohol Drugs 71(3):335-344. T Zorick, RJ Sevak, K Miotto, S Shoptaw, A-N Swanson, C Clement, R De La Garza, TF Newton, ED London (2010): Pilot safety evaluation of varenicline for the treatment of methamphetamine dependence. J. Exp. Pharmacol. 2:13-18. M Bauer, SM Berman, BVoytek, N Rasgon, MA Mandelkern, F Schlagenhauf, PC Whybrow, ED London (2010): Regional cerebral glucose metabolism and anxiety symptoms in bipolar depression: effects of levothyroxine. Psychiatry Res.: Neuroimaging 181: 71-76. MC Tobias, J O’Neill, M Hudkins, G Bartzokis, ED London (2010): White-matter abnormalities in brain during early abstinence from methamphetamine abuse. Psychopharmacology 209:13-24. T Zorick, L Nestor, K Miotto, C Sugar, G Hellemann, G Scanlon, R Rawson, and ED London (2010): Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction 105:1809-1818. C Culbertson, S Nicolas, I Zaharovits, E London, R De La Garza, A Brody, T Newton (2010): Methamphetamine craving induced in an online virtual reality environment. Pharmacol. Biochem. Behav. 96: 454-460. T Zorick, MA Mandelkern, B Lee, M-L Wong, K Miotto, J Shabazian, ED London (2011): Elevated plasma prolactin in abstinent methamphetamine-dependent subjects. Am. J. Drug Alcohol Abuse 37:62-67. DE Payer, MD Lieberman, ED London (2011): Neural correlates of affect processing and aggression in methamphetamine dependence. Arch. Gen. Psychiatry 68: 271-282 A Rapkin, SM Berman, MA Mandelkern, D Silverman, M Morgan, ED London (2011): Neuroimaging evidence of cerebellar involvement in premenstrual dysphoric disorder. Biol. Psychiatry 69: 374-380. G Tabibnia, JR Monterosso, K Baicy, S Chakrapani, B Lee, AR Aron, RA Poldrack, ED London (2011): Different forms of self-control share a neurocognitive substrate. J. Neurosci. 31:4805-4810 DG Ghahremani, G Tabibnia, J Monterosso, G Hellemann, RA Poldrack, ED London (2011): Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals. Neuropsychopharmacology 36:950-959. A Galván, RA Poldrack, CM Baker, KM McGlennen, ED London (2011): Neural correlates of response inhibition and cigarette smoking in late adolescence. Neuropsychopharmacology 36:970-978.

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C Culbertson, MS Cohen, ED London, J Bramen, RE Olmstead, JJ Gan, MR Costello, S Shulenberger, MA Mandelkern, AL Brody (2011): Effect of bupropion HCl treatment on brain activation induced by cigarette cues in smokers. Arch. Gen. Psychiatry. 68(5):505-515. AC Dean, C Sugar, G Hellemann, ED London (2011): Is All Risk Bad? Young adult cigarette smokers fail to take adaptive risk in a laboratory decision-making test. Psychopharmacology. Published online Feb. 5, 2011. doi: 10.1007/s00213-011-2182-y. S Groman, B Lee, ED London, M Mandelkern, A James, K Feiler, R Rivera, M Dahlbom, V Sossi, E Vandervoort, J Jentsch (2011): Dorsal striatal D2-like receptor availability co-varies with sensitivity to positive reinforcement during discrimination learning. J. Neurosci. 31(20):7291-7299. AL Brody, MA Mandelkern, ED London, A Khan, D Kozman, MR Costello, EE Vellios, MM Archie, R Bascom, A Mukhin (2011): Secondhand smoke exposure leads to occupancy of nicotinic acetylcholine receptors in brain. Arch. Gen. Psychiatry. Published online May 2, 2011. doi:10.1001/ archgenpsychiatry.2011.51. T Zorick, B Lee, MA Mandelkern, T Fong, C Robertson, DG Ghahremani, AK Brown, B Sumerel, ED London (2011): Low striatal dopamine receptor availability linked to caloric intake during abstinence from chronic methamphetamine abuse. Mol. Psychiatry Oct 25. doi: 10.1038/ mp.2011.137. [Epub ahead of print]. LJ Nestor, DG Ghahremani, J Monterosso, ED London (2011): Prefrontal hypoactivation during cognitive control in early abstinent methamphetamine-dependent subjects. Psychiat. Res.- Neuroim. 194:287-295. Epub 2011 Nov 1. T Zorick, CA Sugar, G Hellemann, S Shoptaw, ED London (in press): Poor response to sertraline in methamphetamine dependence is associated with sustained craving for methamphetamine. Drug Alcohol Depend. ED London, SM Berman, S Chakrapani, T Delibasi, J Monterosso, HK Erol, G Paz-Filho, M-L Wong, J Licinio (2011): Short-term plasticity of grey matter associated with leptin deficiency and replacement. J. Clin. Endocrinol. Metab. Published online May 25, 2011, doi: 10.1210/jc.2011-0314. K Ishibashi, SM Berman, G Paz-Filho, B Lee, C Robertson, MA Mandelkern, M Wong, J Licinio ED London (in press): Dopamine D2/D3 receptor availability in genetically leptin-deficient patients after long-term leptin replacement. Mol. Psychiatry. D Payer, K Baicy, M Lieberman, ED London (in press): Overlapping neural substrates of intentional and incidental emotion regulation. Emotion. M Hudkins, J O’Neill, MC Tobias, G Bartzokis, ED London (in press): Cigarette smoking and white matter microstructure. Psychopharmacology (Berl.) 2012 Jan 4. [Epub ahead of print] AC Dean, G Hellemann, CA Sugar, SL Simon, ED London (in press): Educational attainment is not a good proxy for cognitive function in methamphetamine dependence. Drug Alcohol Depend. D Payer, E Nurmi, SA Wilson, J McCracken, ED London (in press). Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry. Translational Psychiatry. AK Brown, MA Mandelkern, J Farahi, B Sumerel, N Moallem, ED London (in press). Sex differences in striatal dopamine D2/D3 receptor availability in smokers and nonsmokers. Int. J. Neuropsychopharmacol. CP Domier, ED London (in press). Acute cigarette smoking reduces latencies on a smoking Stroop test. Addict. Behav. http://www.sciencedirect.com/science/article/pii/S0306460312000184

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SM Groman, B Lee, E Seu, AS James, K Feiler, M Mandelkern, ED London, and JD Jentsch (in press): Dysregulation of D2-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure. J. Neurosci. 302. A Morales, B Lee, G Hellemann, J O’Neill, and ED London (in press): Gray-matter volume in methamphetamine dependence: cigarette smoking and changes with abstinence from methamphetamine. Drug Alcohol Depend. 303. DG Ghahremani, B Lee, CL Robertson, G Tabibnia, AT Morgan, N De Shetler, AK Brown, J Monterosso, AR Aron, MA Mandelkern, RA Poldrack, ED London (in press): Striatal dopamine D2/D3 receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans. J. Neurosci. Manuscripts in Review: 1. SP Reise, TM Moore, FW Sabb, AK Brown, ED London. The Barratt Impulsiveness Scale - 11: Reassessment of its structure in a community sample. Psychol. Assessment. 2. SM Berman, ED London, M Morgan, and AJ Rapkin. Reduced age-related loss in gray matter volume of the emotional cerebellum in women with premenstrual dysphoric disorder. World J. Biol. Psychiatry. 3. SM Berman, G Paz-Filho, M Wong, M Kohno, J Licinio, ED London. Effects of leptin deficiency and replacement on cerebellar response to food-related cues. Cerebellum. Manuscripts in Preparation: 1. A Galván, T Schonberg, M Kohno, J Mumford, RA Poldrack, ED London. Greater activation of dorsolateral prefrontal cortex in smokers than in nonsmokers during risk-taking. Neuropsychopharmacology. 2. A-N Swanson, S Shoptaw, K Heinzerling, AC Wade, M Worley, WM Sayers, J McCracken, SA Wilson, J Asarnow, ED London, Up in smoke? A preliminary open-label trial of nicotine replacement therapy and cognitive behavioral motivational enhancement for smoking cessation among youth in Los Angeles. J. Community Health. Books Edited: 1. ED London (1993): Imaging Drug Action in the Brain, CRC Press, Boca Raton, FL. 2. EB de Souza, D Clouet, ED London (1993): Sigma, PCP and NMDA Receptor Systems, NIDA Research Monograph 133, DHHS, Washington, DC. 3. J Henningfield, ED London, S Pogun (2009): Nicotine Psychopharmacology: From Molecule to Behavior, Springer-Verlag, Heidelberg, Germany. Chapters, Reviews and Items other than Original Articles (Articles cited ≥ 50 times are starred) 1. JT Coyle, P Campochiaro, ED London (1978): Neurotoxic action of kainic acid in the developing rat striatum. In: Maturation of Biochemical Neurotransmission. A Vernadakis, E Giacobini, G Filogamo, eds. Karger Publishers, Basel, pp. 134-141. 2. JT Coyle, K Biziere, P Campochiaro, ED London, R Schwarcz, R Zaczek (1978): An animal model for Huntington's disease: Striatal kainic acid lesion. 4th Int. Conf. on Catecholamines, Asilomar. 3. JT Coyle, ED London, K Biziere, Zaczek (1979): Kainic acid neurotoxicity: Insights into the pathophysiology of Huntington's disease. Adv. in Neurol. Vol. 23: Huntington’s Disease. TN Chase, NS Wexler, A Barbeau, eds. Raven Press, New York, pp. 593-608.

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JT Coyle, J Slevin, ED London, K Biziere, J Collins (1981): Characterization of neuronal recognition sites for [3H]kainic acid. In: Psychopharmacology and Biochemistry of Neurotransmitter Receptors. RW Olsen, HI Yamamura, E Usdin, eds. Raven Press, New York, pp. 501-514. SI Rapoport, M Ohata, ED London (1981): Cerebral blood flow and glucose utilization following opening of the blood-brain barrier and during maturation of the rat brain. Fed. Proc. 40:2322-2334. SI Rapoport, ED London (1982): Brain metabolism during aging of the rat & dog - Implications for brain function in man during aging and dementia. In: Aging, Vol. 18: Neural Aging and its Implications in Neurological Pathology. RD Terry, CL Bolis, G Toffano, eds. Raven Press, New York, pp. 79-88. SI Rapoport, R Duara, ED London, RA Margolin, M Schwartz, N Cutler, M Partanen, NL Shinowara (1983): Glucose metabolism of the aging nervous system. In: Aging Vol. 22: Aging of the Brain. D Samuel, S Algeri, S Gershon, VE Grimm, G Toffano, eds. Raven Press, New York, pp 111-121. MJ Ball, H Mersky, M Fisman, IM Fyfe, H Fox, RDT Cape, SB Waller, ED London (1983): Hippocampal morphometry in Alzheimer dementia: Implications for neurochemical hypotheses. In: Banbury Report Vol. 15: Biological Aspects of Alzheimer's Disease. R Katzman, ed. Cold Spring Harbor Laboratories, Cold Spring Harbor, pp. 45-57. ED London, SI Rapoport (1983): Cerebral glucose utilization in the aging rat and beagle: Implications for human brain metabolism during aging and dementia. In: Atherosclerotic Brain Disease. New Trends in Prevention and Treatment of Atherosclerosis. G Crepaldi, R Fellin, AG Olsson, G Toffano, eds. Raven, New York, pp. 45-52. ED London (1984): Metabolism of the brain: A measure of cellular function in aging. In: Aging and Cell Function. JE Johnson, ed. Plenum, New York, pp. 187-210. M Dam, SI Rapoport, ED London (1984): Aging and cholinergic system: A 2-deoxyglucose study in the rat brain. In: Monogr. Neural Sciences Vol. 11: Effects of Aging on Regulation of Cerebral Blood Flow and Metabolism. C Fieschi, GL Lenzi, CW Loeb, eds. Karger, New York, pp. 62-67. R Duara, ED London, and SI Rapoport (1985): Changes in structure and energy metabolism of the aging brain. In: Handbook of the Biology of Aging 2nd edition. CE Finch, E Schneider, eds. Van Nostrand Reinhold Company, New York, pp. 595-616. ED London, M Szikszay, M Dam (1986): Metabolic mapping of the cerebral effects of abused drugs. NIDA Res. Monogr. 67:26-35. ED London (1986): Reversal of cerebral metabolic deficits in rodent models for aging and Alzheimer's disease. In: Alzheimer's and Parkinson's Diseases: Strategies in Research and Development. A Fisher, I Hanin & C Lachman, eds. Plenum, New York, pp. 407-417. ED London, AD Weissman, RJ Fanelli, G Wilkerson, EP Broussolle, JH Jaffe (1986): Mapping the cerebral distributions of action of euphoriant drugs. Clin. Neuropharm. 9: Suppl. 4:208-210. ED London, SB Waller (1986): Relationships between choline acetyltransferase and muscarinic binding in aging rodent brain and in Alzheimer's disease. In: Dynamics of Cholinergic Function. I Hanin, ed. Plenum, New York, pp 215-224. JE Henningfield, JH Jaffe, ED London (1987): Nicotine reward: Studies of abuse liability and physical dependence potential. In: Brain Reward Systems and Abuse. J Engel, L Oreland, eds. Raven Press, New York, pp. 147-164. ED London, R Fanelli, M Szikszay, D Jasinski (1987): Effects of opioid analgesics on local cerebral glucose utilization. NIDA Res. Monogr. 75: 379-381. M Szikszay, FR Snyder, ED London (1987): Effects of morphine and calcium antagonists on plasma glucose in male rats. NIDA Res. Monogr. 75: 382-384. 33

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SB Waller, ED London (1987): Noninvasive diagnostic techniques to study age-related cerebral disorders. In: Psychogeriatrics: An International Handbook. M Bergener, ed. Springer, NY, pp. 172-193. ED London, M Dam, AD Weissman (1987): Different patterns of cerebral glucose utilization produced by phencyclidine and d-N-allylnormetazocine. In: Sigma and Phencyclidine-like Compounds as Molecular Probes in Biology. EF Domino, J-M Kamenka, eds. NPP Books, pp. 297-307. Submitted chapter, "Distribution & cerebral metabolic effects of nicotine" in CE Koop (1988): The Health Consequences of Smoking: Nicotine Addiction, a Report of the Surgeon General. U.S. Govt. Printing Off., Wash., DC. T-P Su, ED London, JH Jaffe (1989): Steroid binding at σ "opioid" receptor: Response to a technical comment. Science 246:1637-1638. ED London (1990): Effects of nicotine on cerebral metabolism. In: The Biology of Nicotine Dependence, Ciba Foundn. Symp. #152. G Bock, J Marsh, eds. Wiley, Chichester, pp. 131-146. ED London (1990): Glucose metabolism: An index of nicotine action in the brain. In: Proc. International Symposium on Nicotine. Advances in Pharmacological Sciences. A Adlkofer, ed. Birkhauser Verlag, Basel, pp. 239-248. ED London, VL Dawson, CR Mantione (1990): Specific binding sites for polyamines in mammalian brain. In: NMDA Related Agents: Biochemistry Pharmacology and Behavior. T Nabeshima, T Kameyama, EF Domino, eds. NPP Books, Ann Arbor, MI, pp. 71-78. T-P Su, X-Z Wu, CE Spivak, ED London, JA Bell (1990): Binding studies on intact NCB-20 cells suggest receptor multiplicity: σ1 and σ2. In: NMDA Related Agents: Biochemistry Pharmacology and Behavior. T Nabeshima, T Kameyama, EF Domino, eds. NPP Books, Ann Arbor, MI 227-234. ED London, MJ Morgan, RL Phillips, JM Stapleton, NG Cascella, DF Wong (1991): Mapping the metabolic correlates of drug-induced euphoria. NIDA Res. Monogr. 105:54-60. ED London, MJ Morgan (1993): Positron emission tomography studies on the acute effects of psychoactive drugs on brain metabolism and mood. In: Imaging Drug Action in the Brain. ED London, ed. CRC Press, Boca Raton, FL, pp. 265-280. ED London, SR Zukin (1993): Sigma receptors, PCP receptors and the developing nervous system. In: Receptors in the Developing Nervous System, Volume 2: Neurotransmitters. IS Zagon, PJ McLaughlin, eds. Chapman & Hall, London, pp 215-230. ED London: Studies of receptors and metabolic responses to σ ligands in the brain (1993): NIDA Res. Monogr. 133:55-68. ED London (1993): Seeing the brain: The role of PET, autoradiography, and other imaging techniques. In: Biomedical Approaches to Illicit Drug Demand Reduction. CR Hartel, ed. Proc. Int. Res. Conf., Sea Island, GA, Feb. 24-26, 1992, NIDA, NIH Pub. No. 93-3698, pp. 235-241. K Hashimoto, ED London (1994): Imaging sigma receptors and cerebral responses to sigma drugs. In: Sigma Receptors. Y. Itzhak, ed. Academic Press, Miami, FL, pp. 225-242. ED London (1994): Positron emission tomography in studies of drug abuse. NIDA Res. Monogr. 138:15-24. DK Ingram, EL Spangler, S Iijima, H Kuo, EL Bresnahan, NH Greig, and ED London (1994): New pharmacological strategies for cognitive enhancement using a rat model of age-related memory impairment. Ann. NY Acad. Sci. 717:16-32. K Hashimoto, ED London (1994): Specific binding sites for polyamines in brain. In: Neuropharmacology of Polyamines. CJ Carter, ed. Academic Press, London, pp. 155-165. ED London (1994): Patterns of nicotine action in the brain. Tob. Control 3:101. 34

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MJ Morgan, ED London (1995): The use of positron emission tomography to study the acute effects of addictive drugs on cerebral metabolism. In: Sites of Drug Addiction in the Human Brain. A Biegon, ND Volkow, eds. CRC Press, Boca Raton, FL, pp. 159-172. ED London (1995): Brain metabolism in substance abusers. NIDA Res. Monogr. 152(1) Problems of Drug Dependence 1994: Ann. Meeting Proceedings, College on Problems of Drug Dependence, pp. 58. DB Vaupel, AS Kimes, and ED London (1995): Attenuation of opioid withdrawal: Pharmacological profiles of nitric oxide synthase inhibitors. NIDA Res. Monogr. 153(2):103. X Liu, RL Phillips, SM Resnick, DF Wong, JM Stapleton, VL Villemagne, and ED London (1995): No evidence for ventriculomegaly in polysubstance abusers: A volumetric magnetic resonance imaging study. NIDA Res. Monogr. 153(2):209. ED London, A Mukhin (1995): Polyamines as endogenous modulators of the N-methyl-D-aspartate receptor. Ann. NY Acad. Sci. 757:430-438. ED London (1995): Mapping the cerebral metabolic responses to nicotine. In: Brain Imaging of Nicotine and Tobacco Smoking. EF Domino, ed. NPP Books Inc., Ann Arbor, MI, pp 153-166. ED London, S Grant, D Newlin (1995): Identifying the substrates in brain that underlie cocaine craving. NIH Catalyst May/Jun. pp. 10,11,22. ED London, AS Kimes, DB Vaupel (1995): Inhibitors of nitric oxide synthase and the opioid withdrawal syndrome. NIDA Res. Monogr. 147:170-181. JM Stapleton, ED London (1995): Imaging techniques: visualizing the living brain. In: Encyclopedia of Drugs & Alcohol Vol 2, JH Jaffe, ed. Macmillan, New York, NY, pp. 573-576. ED London, SJ Grant, MJ Morgan, SR Zukin (1996): Neurobiology of drug abuse. In: Neuropsychiatry: a Comprehensive Textbook. BS Fogel, RB Schiffer, SM Rao, eds. Balto. MD, Williams and Wilkins, pp. 635-678. ED London, JM Stapleton, RL Phillips, SJ Grant, VL Villemagne, X Liu, R Soria (1996): PET studies of cerebral glucose metabolism: Acute effects of cocaine and long-term deficits in brains of drug abusers. NIDA Res. Monogr. 163: 146-158. DK Ingram, A Shimada, A Mukhin, ED London (1996): Evaluating the glutamate hypothesis of geriatric memory impairment: Focus on hippocampal NMDA receptors. Perspect. Brain Aging Res. 1:30-35.

* ED London, NG Cascella, DF Wong, RL Phillips, RF Dannals, JM Links, R Herning, R Grayson, JH Jaffe, HN Wagner, Jr. (1997): Cocaine induced reduction of glucose utilization in human brain: a study using positron emission tomography and [fluorine 18]-fluorodeoxyglucose, In: Drug Abuse in the Decade of the Brain, GG Nahas and Tf Burks, eds., chapter 22, p 191-206 [62 citations]. FJ Vocci; ED London (1997): Assessment of neurotoxicity from potential medications for drug abuse: ibogaine testing and brain imaging. Ann. NY Acad. Sci. 820:29-39; discussion 39-40. M Ernst, ED London (1997): Brain imaging studies of drug abuse: Therapeutic implications. Seminars in Neurosci. 9:120-130. ED Morris, Chefer SI, ED London (1998): Limitations of binding potential as a measure of receptor function. A two-point correction for the effects of mass. In: Quantitative Functional Brain Imaging with Positron Emission Tomography, RE Carson, P Herscovitch, ME Daube-Witherspoon, eds. Academic Press, San Diego, CA, pp. 407-413. M Ernst, ED London (1998): More ethical challenges: commentary on Fischman and Johanson's ethical and practical issues involved in behavioral pharmacology research that administers drugs of abuse to human volunteers. Behav. Pharmacol. 9(7): 499-501. 35

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* ED London, KR Bonson, M Ernst, S Grant (1999): Brain imaging studies of cocaine abuse: Implications for medication development. Crit. Rev. Neurobiol. 13(3): 227-242 [56 citations]. ED London, KR Bonson, S Grant (1999): Brain imaging to develop treatments for drug abuse. Paradigm Magazine 4 (3):14-18. Quest Publishing Company. ED London, FJ Vocci (2000): Neurosciences II – Biomarkers for alcohol and drug abuse. In Biomarkers and Surrogate Endpoints: Clinical Research and Applications. Proceedings of NIH-FDA conference (Apr. 15-16, 1999; Bethesda, MD). GJ Downing, ed., Elsevier, Amsterdam & New York, pp. 119-131.

* W Sihver, A Nordberg, B Långström, AG Mukhin, AO Koren, AS Kimes, ED London (2000): Development of ligands for in vivo imaging of cerebral nicotinic receptors. Behav. Brain Research 113(1-2): 143-57 [71 citations].

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* ED London, M Ernst, S Grant, K Bonson, A Weinstein (2000): Orbitofrontal cortex and human drug abuse: Functional imaging. Cerebral Cortex 10:334-342 [246 citations]. SI Chefer, A Mukhin, AG Horti, AO Koren, O Pavlova, V Kurian, M Stratton, AS Kimes, ED London (2000). 2-[18F]Fluoro-A-85380: A novel PET ligand for nicotinic acetylcholine receptors. Proc. Int. Conf. Math. & Engineering Techs. in Medicine and Biol. Sci. (METMBS’00) 2: 409-415, F. Valafar, ed. CSREA Press, Las Vegas, NV. AG Mukhin, SI Chefer, A Horti, AO Koren, DB Vaupel, D Gündisch, O Pavlova, M Stratton, V Kurian, AS Kimes, ED London (2000): Radiohalogenated analogues of A-85380 as potential ligands for in vivo monitoring of the α4β2 nicotinic receptor alteration in Alzheimer’s disease. Proc. Int. Conf. Math. & Engineering Techs. in Med. & Biol. Sci. 2:429-435, F. Valafar, ed. CSREA Press, Las Vegas, NV. DK Ingram, S Chefer, J Matochik, TD Moscrip, J Weed, GS Roth, ED London, MA Lane (2001): Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies. Ann. NY Acad. Sci. 928:316-326. SR Cherry, ED London, YC Tai, LA Fairbanks (2001): Development of a molecular imaging laboratory at the Sepulveda VA vervet research center. ONDCP Int. Technol. Symp. Proc. 1:33-39, Jun 25-28, San Diego, CA. AS Kimes, SI Chefer, DB Vaupel, O Pavlova; AO Koren; C Contoreggi, ED London, A Mukhin (2001): PET imaging of nicotine acetylcholine receptors. A method to test hypotheses on the role of nAChRs in facilitating drug-abuse behavior. ONDCP Int. Technol. Symp. Proc. 1:140-149, Jun. 25-28, San Diego, CA. DH Fishbein, C Hyde, ED London, J Matochik, M Ernst, N Isenberg, B Schech, A Kimes (2001): Cognitive and physiological differences between abstinent drug abusers and controls. 2001 ONDCP Intl. Technology Symposium Proceedings 1:158-175, Jun 25-28, San Diego, CA. CJ Endres, AS Dogan, JR Brasic, Y Zhou, J Hilton, ED London, and DF Wong (2002): Comparison between bolus and infusion [11C]raclopride delivery for the quantification of dopamine release, In: Brain Imaging Using PET. M Senda, Y Kimura, P Herscovitch, eds. Elsevier, Amsterdam, pp.71-75. JL Obert, ED London, RA Rawson (2002): Incorporating brain research findings into standard treatment: an example using the Matrix Model. J. Substance Abuse Treatment. 23:107-113. RD Mayfield, RL Popp, TK Machu, SJ Grant, MJ Morgan, SR Zukin, ED London (2003): Neurobiology of drug abuse, In: Neuropsychiatry, 2nd ed. Fogel BS, Schiffer RB, and Rao SM, editors. Balto., MD, Williams & Wilkins, pp. 840-892. M Bauer, ED London, DHS Silverman, N Rasgon, J Kirchheiner, PC Whybrow (2003): Thyroid, brain and mood modulation in affective disorder: Insights from molecular research and functional brain imaging. Pharmacopsychiatry 36: Suppl. 3:S215-S221. 36

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K Baicy, CE Bearden, J Monterosso, AL Brody, AJ Isaacson, ED London (2005): Common substrates of dysphoria in stimulant drug abuse and primary depression: therapeutic targets. Int. Rev. Neurobiol. 65: 117-145. K Baicy, ED London (2007): Corticolimbic dysregulation and chronic methamphetamine abuse. Addiction 102: Suppl 1:5-15. I Ivanov, KP Schulz, ED London, JH Newcorn (2008): Inhibitory control deficits in childhood and risk for substance abuse disorders. Am. J. Drug Alc. Abuse 34:239-258. S Berman, J O’Neill, S Fears, G Bartzokis, ED London (2008): Abuse of amphetamines and structural abnormalities in brain. Ann. N.Y. Acad. Sci. 1141:195-220. RM Bilder, R Poldrack, DS Parker, SP Reise, JD Jentsch, T Cannon, ED London, FW Sabb, L Foland, A Rizk-Jackson, D Kalar, N Brown, A Cartensen, N Freimer (2009): Cognitive phenomics, In: Handbook of Neuropsychology of Mental Disorders. S Wood, N Allen, C Pantelis (eds.), Cambridge Univ. Press, Cambridge, UK. DE Payer and ED London (2009): Methamphetamine and the brain: findings from brain imaging studies, In: Methamphetamine: A Guide for Practitioners. J. Roll, R. Rawson, W. Ling, and S. Shoptaw (eds.), Guilford Press NY, pp. 61-91. A Azizian, J Monterosso, J O’Neill, ED London (2009): Magnetic resonance imaging studies of cigarette smoking and nicotine dependence, In: Nicotine Psychopharmacology: from Molecule to Behavior. JE Henningfield, ED London, S Pogun (editors), Springer-Verlag, Heidelberg, Germany. SM Berman, RT Kuczenski, JT McCracken, ED London (2009): Potential adverse effects of amphetamine treatment on brain and behavior: a review. Mol. Psychiatry 14(2):123-142. ED London (2009): Studying Addiction in the age of neuroimaging: Marian W. Fischman memorial lecture. Drug Alcohol Depend. 100:182-185. RM Bilder, FW Sabb, TD Cannon, ED London, JD Jentsch, DS Parker, RA Poldrack, C Evans, NB Freimer (2009): Phenomics: The systematic study of phenotypes on a genome-wide scale. Neuroscience 164(1):30-42.

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J Jarcho, E Mayer, ED London (2009): Neuroimaging placebo effects: New tools generate new questions. Clin. Pharmacol. Ther. 86(4):352-354.

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AC Dean, ED London (2010): Cognitive dysfunction and cerebral deficits associated with methamphetamine abuse, In: Substance Abuse and Emotion. JD Kassel (ed.), Am. Psychol. Assoc., pp. 237-257. JR Monterosso, T Mann, A Ward, G Ainslie, J Bramen, A Brody, ED London (2010): Neural recruitment during self-control of smoking: a pilot fMRI study. In What is Addiction? D Ross, H Kincaid, D Spurrett, P Collins (eds.), MIT Press, Cambridge, MA, pp. 269-290. ED London (2011): Foreword, In Neuroimaging in the Addictions. B Adinoff & E Stein (eds.), Wiley-Blackwell, Chicester, UK, pp. xi-xiii. J Jarcho, E Mayer, K Jiang, ED London (in press). Pain, affective symptoms and cognitive deficits in patients with cerebral dopamine dysfunction. Pain.

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Nonscientific Articles: 1. ED London (2007, Nov. 1). Why I use laboratory animals in my research. The Los Angeles Times. Abstracts: 37

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ED London, JW Hauswirth, FD Kundig, PP Nair (1972): Dependence of heme biosynthesis on vitamin E status and age -- modulation by phenobarbital. Fed. Proc. 31:713. ED London, GG Buterbaugh (1975): Convulsant thresholds in developing rats: Effect of tetrabenazine. Fed. Proc. 34:624. ED London, FJ Vocci, GG Buterbaugh (1977): Age-dependent modification of the maximal electroshock convulsive threshold by central monoamine reduction in rats. Pharmacologist 19:14. ED London, JT Coyle (1977): Pharmacologic augmentation of acetylcholine levels in kainatelesioned rat striatum. Soc. Neurosci. Abstr. 3:41. ED London, JT Coyle (1978): Characterization of a CNS binding site for the neurotoxin kainic acid. Fed. Proc. 37:907. ED London, LW Harris, WC Heyl, JT Coyle (1978): Effect of Deanol in kainate-lesioned rat striatum: Anomaly in the radioenzymatic assay of acetylcholine. Pharmacologist 20:247. ED London, N Klemm, JT Coyle (1979): Phylogenetic distribution of [3H]-kainic acid receptor binding sites in neural tissue. Soc. Neurosci. Abstr. 5:407. ED London, S Nespor, L Moore, P Mahone, SI Rapoport (1979): Age-dependent changes in local cerebral glucose utilization. Age 2:131. ED London, G Schattschneider, HI Yamamura, JT Coyle (1980): Decreased kainic acid binding sites in Huntington's diseased brain. Fed. Proc. 39:388. D Dow-Edwards, JM Peterson, P Mahone, SI Rapoport, ED London (1980): Effect of oxotremorine, a muscarinic agonist, on local cerebral glucose utilization in the rat. Soc. Neurosci. Abstr. 6:769. AS Garden, M Ohata, SI Rapoport, ED London (1980): Age-associated decrease in local cerebral glucose utilization (LCGU) in the Beagle. Soc. Neurosci. Abstr. 6:768. M Ohata, U Sundaram, WR Fredericks, ED London, SI Rapoport (1980): Age-associated alterations in regional cerebral blood flow in the Fischer-344 rat. Soc. Neurosci. Abstr. 6:768. NL Shinowara, SI Rapoport, MJ Hoover, ED London (1980): Changes in retinal morphology and local glucose utilization (LGU) in 1 to 34 month old Fischer-344 rats. Soc. Neurosci. Abstr. 6:346. SI Rapoport, WR Fredericks, D Dow-Edwards, ED London (1980): Increased local cerebral glucose utilization (LCGU) following opening of the blood-brain barrier by hypertonic arabinose infusion or by acute hypertension. Soc. Neurosci. Abstr. 6:829. ED London, JM Palacios, SI Rapoport, MJ Kuhar (1980): Local cerebral glucose utilization following systemic administration of GABAergic agonist and antagonist drugs. Soc. Neurosci. Abstr. 6:7. ED London, M Ohata, SI Rapoport (1980): Local cerebral glucose utilization and regional blood flow during development, maturation and aging of the Fischer-344 rat. Gerontologist 20:(5) Suppl. II:252. ED London, S Nespor, SI Rapoport (1980): Age-associated decreases in local cerebral glucose utilization. In: Neural Regulatory Mechanisms During Aging ed. by RC Adelman, G Baker, V Cristofalo, J Roberts. Alan R Liss, Inc. New York, pp. 193-194. NL Shinowara, MJ Hoover, SI Rapoport, ED London (1980): Comparison of retinal changes in morphology & glucose utilization in aging Fisher-344 rats. In: Neural Regulatory Mechanisms During Aging; R Adelman, G Baker, V Cristofalo, J Roberts, eds., Alan R Liss, Inc. New York, pp. 191-192. M Dam, H Holloway, P Mahone, D Dow-Edwards, ED London (1981): Oxotremorine increases glucose utilization in the Papez circuit. Trans. Am. Soc. Neurochem. 12:141. ED London, M Dam, J Palacios, M Kuhar, S Rapoport (1981): Relation of metabolic drug responses to receptor distribution. Trans. Am. Soc. Neurochem. 12:141. 38

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ED London, M Ohata, SI Rapoport (1981): Cerebral glucose utilization during aging of the rat and dog: Implications for brain metabolism in man during aging and dementia. Eur. Atherosclerosis Group Spring meeting "Atherosclerotic Brain Disease" May 26-27, Padova, Italy. SI Rapoport, ED London, H Takei, M Ohata (1981): Cerebral metabolism and blood flow during aging of the Fischer-344 rat. Symposium on Physiological and Pathophysiological Aspects of the Aging Brain, Jul 9-11, Heidelberg, Germany. SB Waller, DK Ingram, MA Reynolds, ED London (1981): Neurochemical changes as a function of genotype and age in mice. Soc. Neurosci. Abstr. 7:186. H Takei, W Fredericks, ED London, SI Rapoport (1981): Cerebral blood flow and metabolic rates for oxygen, glucose & carbon dioxide in Fischer-344 rats of different ages. Soc. Neurosci. Abstr. 7:369. SB Waller, DK Ingram, MA Reynolds, ED London (1982): Changes in neurotransmitter synthetic enzymes as a function of genotype and age. Age 4:143. DK Ingram, ED London, MA Reynolds, SB Waller, CL Goodrick (1982): Differential effects of age on motor performance in two inbred mouse strains. Age 4:138. GS Sundaram, S Manimekalai, RS London, MA Reynolds, ED London (1982): Age effects on plasma and lipoprotein cholesterol and related enzymes in the rat. Age 4:150. ED London, P Mahone, SI Rapoport, M Dam (1982): Effect of age on oxotremorine-induced stimulation of local cerebral glucose utilization. Fed. Proc. 41:1323. R Duara, RA Margolin, EA Robertson-Tchabo, ED London, M Schwartz, JW Renfrew, R Kessler, L Sokoloff, DH Ingvar, SI Rapoport (1982): Regional cerebral glucose utilization in healthy men at different ages. Neurology 32:A166-A167. SB Waller, ED London (1982): Increased Vmax for choline acetyltransferase in brain regions of aged C57BL/6J mice. Fed. Proc. 41:1308. M Dam, SI Rapoport, ED London (1982): Dose-dependent stimulation of local cerebral glucose utilization by physostigmine. Fed. Proc. 41:1308. ED London, SI Rapoport, M Dam (1982): Effect of age on oxotremorine-induced stimulation of local cerebral glucose utilization. 10th Aharon Katzir-Katchalski Conf. on Aging of the Brain. Mantua, Mar. 26-29. P Helén, ED London (1982): Muscimol-scopolamine interactions in the rat brain: A study with 14 [ C]2-deoxy-D-glucose. Soc. Neurosci. Abstr. 8:579. SB Waller, ED London (1982): Kinetic studies of choline acetyltransferase and muscarinic receptor binding in aged C57BL/6J mice. Soc. Neurosci. Abstr. 8:518. ED London, M Dam (1982): Stimulation of local cerebral glucose utilization in the rat visual system by physostigmine. Soc. Neurosci. Abstr. 8:775. ED London, SI Rapoport, M Dam (1982): Age-related decrease in oxotremorine-induced stimulation of local cerebral glucose utilization. In: Energy Transduction and Neuro-transmission, ed. by G Benzi, AM Giuffrida Stella, H S Bachelard, A Agnoli. Fondazione Int. Menarini, Milano, p. 214. MJ Ball, H Merskey, M Fisman, I Fyfe, H Fox, R Cape, S Waller, ED London (1983): Hippocampal morphometry and chemistry in Alzheimer's dementia. J. Neuropathol. Exp. Neurol. 42:335. ED London, M McKinney, M Dam, JT Coyle (1983): Decreased cortical glucose utilization after ibotenate lesion of the rat globus pallidus: Effect of oxotremorine. Pharmacologist 25:626. SB Waller, MJ Ball, ED London (1983): Choline acetyltransferase and muscarinic binding in Alzheimer's diseased brain. Pharmacologist 25:626. 39

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ED London, DK Ingram, SB Waller (1983): Effects of dietary restriction on neurotransmitter synthetic enzymes and muscarinic binding in aging rat brain. Soc. Neurosci. Abstr. 9:98. SB Waller, MJ Ball, ED London (1983): Choline acetyltransferase and muscarinic binding in regions of normal and Alzheimer's diseased brains. Soc. Neurosci. Abstr. 9:1052. AM Lowy, DS Olton, DK Ingram, SB Waller, MS Reynolds, ED London (1983): Age and neurochemical correlates of behavioral rigidity in rats. Soc. Neurosci. Abstr. 9:96. DE Bernstein, D Olton, D Ingram, S Waller, M Reynolds, ED London (1983): Performance of young and aged mice in an eight arm radial maze and neurochemical correlates. Soc. Neurosci. Abstr. 9:98. SI Rapoport, R Duara, ED London (1983): Brain metabolism in the aging Fischer-344 rat. Continuing Medical Educ., Syllabus & Scientific Proceedings, Am. Psychiatry. Assoc. Apr., p. 237. MJ Ball, H Merskey, M Fishman, R Cape, H Fox, I Fyfe, S Waller, ED London (1983): Hippocampal analysis in Alzheimer's disease: Chemical and morphometric changes. Can. J. Neurol. Sci. 10:156. ED London, SB Waller (1983): Choline acetyltransferase and muscarinic binding in aged rat and mouse brain. Age 6:133. D Bernstein, DS Olton, DK Ingram, SB Waller, MA Reynolds, ED London (1983): Radial maze performance in young and aged mice: A behavioral and neurochemical analysis. Age 6:134. A Lowy, D Olton, D Ingram, S Waller, MA Reynolds, ED London (1983): Performance of young and aged rats in a T-maze: Behavioral-neurochemical correlates. Age 6:134. ED London, SB Waller (1983): Relations between choline acetyltransferase and muscarinic binding in aging & Alzheimer's disease. Int. Conf. Dynamics of Cholinergic Function, Oct 30-Nov 4, Oglebay, WV. MJ Ball, M Fisman, H Merskey, I Fyfe, H Fox, S Waller, ED London (1983): Correlative study of chemical and morphometric changes in hippocampi in Alzheimer dementia. Gerontologist 23:247. RC Walovitch, ED London (1984): Naloxone selectively increases local cerebral glucose utilization in rats. Fed. Proc. 43:741. ED London, SB Waller, JK Wamsley (1984): Autoradiographic localization of [3H]nicotine binding sites in the rat brain. Soc. Neurosci. Abstr. 10: 556. RC Walovitch, ED London (1984): Acute Hydergine treatment selectively increases local cerebral glucose utilization in rats. Soc. Neurosci. Abstr. 10: 541. PM Wise, IR Cohen-Becker, N Weiland, R Walovitch, ED London (1984): Age effects and circadian periodicity in local cerebral glucose utilization in ovariectomized female rats. Soc. Neurosci. Abstr. 10:449. JE Johnson, J White, A Hervonen, R Walovitch, ED London (1984): Effects of subchronic morphine treatment on the fine structure of the rat superior cervical ganglion. Soc. Neurosci. Abstr. 10:164. RF Mervis, S Moroi, ED London, DK Ingram (1984): Effect of dietary restriction on dendritic spines in aging rat neocortex. Age 7:144. ED London, RC Walovitch (1984): Enhanced local glucose utilization in many subcortical regions of the rat brain following acute co-dergocrine treatment. International symposium: New Experimental Findings on Hydergine (Sandoz), Paris, Oct 29. ED London, RC Walovitch (1985): Pharmacological treatment of cerebral metabolic deficits in rodent models for aging and Alzheimer's disease. OHOLO Biol. Conf., Mar 24-27, Eilat, Israel. M Selmanoff, RC Walovitch, GE Walker, ED London (1985): Effects of hyperprolactinemia on plasma prolactin and glucose and on local cerebral glucose utilization. Proc. Endocr. Soc., p. 42. 40

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M Szikszay, G Benedek, ED London (1985): Physiological interactions of morphine and diltiazem in rats. Soc. Neurosci. Abst. 11:1071. RC Walovitch, MK Selmanoff, F Snyder, ED London (1985): Increases in median eminence glucose utilization & suppression of plasma prolactin levels by naloxone in rats. Soc. Neurosci. Abst. 11:1197. JA Bell, AS Kimes, ED London (1985): Local stimulation of glucose utilization in the spinal cord during naloxone-precipitated opioid abstinence. Soc. Neurosci. Abst. 11:1070. ED London, RJ Connolly, M Szikszay, JK Wamsley, M Dam (1985): Distribution of cerebral metabolic effects of nicotine in the rat. Soc. Neurosci. Abst. 11:654. AS Kimes, RC Walovitch, ED London (1985): Quantitation of local cerebral glucose utilization during opioid dependence and naloxone- precipitated withdrawal. Soc. Neurosci. Abstr. 11:1151. PM Wise, ED London, IR Cohen-Becker, NG Weiland (1985): Circadian rhythm of local cerebral glucose utilization in estradiol-treated ovariectomized rats: Effects of age. Soc. Neurosci. Abstr. 11:951. M Dam, R Connolly, G Wilkerson, ED London (1985): Effects of nicotine on glucose utilization in the rat brain visual system. Soc. Neurosci. Abstr. 11:231. SB Waller, MJ Ball, MA Reynolds, ED London (1986): Muscarinic binding and choline acetyltransferase activity in postmortem brains of demented patients. 1st Canadian Symposium on the Organic Dementias, June, London, Ontario. G Wilkerson, M Risner, S Goldberg, ED London (1986): Effects of cocaine on local cerebral glucose utilization in the rat. Trans. Am. Soc. Neurochem. 17:161. G Wilkerson, ME Risner, SR Goldberg, ED London (1986): Effects of l-cocaine on local cerebral glucose utilization in the rat. Pharmacologist 28:236. P Wise, E London, I Cohen-Becker, N Weiland (1986): Effect of estradiol on local cerebral glucose utilization in ovariectomized rats. Deutsche Geselschaft Endokr. 30. Symp. 12. 15 Marz, Munchen. ED London, RJ Fanelli, M Szikszay, DR Jasinski (1986): Local cerebral glucose utilization in the rat following administration of opioid analgesics. Int. Narcotics Res. Conf. July, San Francisco. M Szikszay, ED London (1986): Interaction of morphine and calcium antagonists on plasma glucose in male rats. Int. Narcotics Res. Conf. July, San Francisco. JE Jaffe, ED London, J Henningfield (1986): Nicotine dependence and psychopharmacology. 3rd World Cong. Clin. Pharmacol. & Ther., Stockholm, Jul 27 - Aug 1, Int. Union Pharmacol., Nordic Pharmacol. Soc. & Swedish Soc. Med. Sciences. ED London, E Broussolle, M Dam (1986): Acute effects of diazepam on local cerebral glucose utilization in the rat. Soc. Neurosci. Abstr. 12:178. E Broussolle, D Wong, ED London (1986): In vivo binding of [3H]l-nicotine in the mouse brain. Soc. Neurosci. Abstr. 12:1333. RJ Fanelli, M Szikszay, RC Walovitch, DR Jasinski, ED London (1986): Cerebral glucose utilization in the rat following administration of opioid analgesics and naloxone. Soc. Neurosci. Abstr. 12:408. M Dam, AD Weissman, ED London (1986): Sigma agonist actions on brain local cerebral glucose utilization by +SKF-10, 047. Soc. Neurosci. Abstr. 12:1410. M Szikszay, ED London (1986): Capsaicin effect on regional glucose utilization in the rat central nervous system. Soc. Neurosci. Abstr. 12:957. AD Weissman, M Dam, ED London (1986): Phencyclidine induces selective changes in brain glucose utilization. Soc. Neurosci. Abstr. 12:179. 41

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AS Kimes, JA Bell, ED London (1986): Effect of clonidine on cerebral glucose utilization during naloxone precipitated abstinence in morphine dependent rats. Soc. Neurosci. Abstr. 12:408. AD Weissman, M Dam, ED London (1986): Differentiation of phencyclidine and sigma effect on local cerebral glucose utilization in rats. Pharmacologist 28:224. G Wilkerson, ED London (1987): (+) 3,4-Methylenedioxymethamphetamine (MDMA) effects on cerebral glucose utilization in the rat. Fed. Proc. 511:404. AD Weissman, KL Marquis, JE Moreton, ED London (1987): Effects of self-administered phencyclidine on regional brain uptake of 2-deoxy-D-[l-14C]glucose. Fed. Proc. 511:404. AS Kimes, JA Bell, ED London (1987): Interaction between the effects of naloxone-precipitated morphine-withdrawal and clonidine on cerebral glucose utilization. J. Neurochem. 48:S94. ED London, E Broussolle, J Links, D Wong, R Dannals, H Wagner, L Rippetoe, B Holicky, R Herning, W Pickworth, J Toung, J Jaffe (1987): Morphine effect on brain metabolism in postaddicts. Am. Psychiatric Assoc. 140th Annual Meeting May 9-15, Chicago IL. AD Weissman, T-P Su, JC Hedreen, DL Price, ED London (1987): Sigma receptors demonstrated in human postmortem brains. Neuroscience Suppl. 22:S85. E Broussolle, ED London, J Links, D Wong, R Dannals, H Wagner, L Rippetoe, B Holicky, R Herning, W Pickworth, F Snyder, N Cascella, J Toung, JH Jaffe (1987): Morphine decreases regional cerebral glucose utilization in human postaddicts. J. Nucl. Med. 28:1074. ED London, M Dam, A Weissman (1987): Different patterns of cerebral glucose utilization produced by phencyclidine and (+)N-allylnormetazocine. 2nd US-French Sponsored Int. Seminar on Sigma Opioid/PCP-like Compounds as Molecular Probes in Biology, Ann Arbor MI. ED London, E Broussolle, J Links, DF Wong, RF Dannals, HN Wagner Jr., LR Rippetoe, B Holicky, RI Herning, WB Pickworth, FR Snyder, N Cascella, JKT Toung, RA Margolin, JH Jaffe (1987): Human opioid abusers show regional decreases in cerebral glucose utilization during morphine euphoria. Soc. Neurosci. Abstr. 13:813. C Ori, ED London (1987): Alterations in κ and μ opioid receptor binding by volatile anesthetics in vitro. Soc. Neurosci. Abstr. 13:640. TH Vu, AD Weissman, ED London (1987): Phylogenetic distribution of haloperidol-sensitive sigma and phencyclidine binding sites in the nervous system. Soc. Neurosci. Abstr. 13:1703. AD Weissman, EP Broussolle, ED London (1987): In vivo binding of [3H]haloperidol and [3H]dSKF 10,047 in mouse brain. Soc. Neurosci. Abstr. 13:1130. G Wilkerson, SR Goldberg, M Risner, ED London (1987): Differential sensitivity to cocaine in Lewis and Fischer-344 rats as indicated by local cerebral glucose utilization. Soc. Neurosci. Abstr. 13:1414. RJ Fanelli, ED London (1987): Effects of chronic nicotine on local cerebral glucose utilization in the rat. Soc. Neurosci. Abstr. 13:1633. AS Kimes, WJ Smith, CP Jaffe, ED London (1987): Effects of morphine on the phenotypic expression of T-lymphocyte cell surface markers in the mouse. Soc. Neurosci. Abstr. 13:1437. SR Cohen, ED London (1987): The influence of pain and morphine on local cerebral glucose utilization in the rat. Soc. Neurosci. Abstr. 13:302. ED London, NG Cascella, DF Wong, M Sano, RF Dannals, J Links, RI Herning, JKT Toung, HN Wagner Jr., JH Jaffe (1988): Acute cocaine decreases regional cerebral glucose utilization in human substance abusers. J. Nucl. Med. 29:840.

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NG Cascella, ED London, DF Wong, G Pearlson, RF Dannals, J Links, EP Broussolle, HN Wagner Jr., JH Jaffe (1988): Relation between measures of brain structure and cerebral glucose utilization in polydrug abusers. J. Nucl. Med. 29:91l. B Tabakoff, ED London, S Marietta, G Szabo (1988): Peptide-T and VIP effects on brain metabolism. IV International Conference on AIDS, June 12-16, 1988, Stockholm, Sweden. E Broussolle, ED London, J Links, DF Wong, RF Dannals, HV Wagner Jr., LR Rippetoe, B Holicky, R Herning, WB Pickworth, FR Snyder, NG Cascella, JKT Toung, RA Margolin, JH Jaffe (1988): Human cerebral metabolism decreases during morphine induced euphoria: a PET study. Eighth European Winter Conf. on Brain Research. Tignes, France, Mar 6-12. ED London, NG Cascella, DF Wong, M Sano, RF Dannals, J Links, RI Herning, JKT Toung, HN Wagner Jr., JH Jaffe (1988): Acute cocaine decreases regional cerebral glucose utilization in human substance abusers. Soc. Neurosci. Abstr. 14:919. AS Kimes, G Wilkerson, C Ori, ED London (1988): Central action of psychomotor stimulants on local cerebral glucose utilization in extrapyramidal motor areas. Soc. Neurosci. Abstr. 14:918. M Sano, N Cascella, B Glover, R Herning, ED London (1988): EEG and subjective responses to intravenous cocaine in human substance abusers. Soc. Neurosci. Abstr. 14:963. H Takayama, MD Majewska, ED London (1988): Interactions of allosteric antagonists with nicotinic acetylcholine recognition sites in brain. Soc. Neurosci. Abstr. 14:230. F Ford-Rice, A della Puppa, F Snyder, E Cone, ED London (1988): Interactions between verapamil injection time and morphine effects on physiological parameters in rats. Soc. Neurosci. Abstr. 14:542. A della Puppa, JL Cadet, ED London (1988): Glucose utilization in discrete brain areas after chronic administration of iminodipropionitrile in rats. Soc. Neurosci. Abstr. 14:918. JA Bell, CE Spivak, T-P Su, ED London (1988): Haloperidol-sensitive, a selective electrophysiological effect of sigma ligands on NCB-20 cells. Soc. Neurosci. Abstr. 14:1155. AD Weissman, MF Casanova, JB Kleinman, ED London, EB de Souza (1988): Regional differences in PCP and sigma binding in the brains of schizophrenics. Soc. Neurosci. Abstr. 14:104. RI Herning, BJ Glover, M Sano, N Cascella, R Reddish, E London, JH Jaffe (1988): The cortical and temporal mapping of EEG changes produced by intravenous cocaine. Soc. Psychophysiol. Res. Oct 19-23, San Francisco. NG Cascella, DG Wong, G Pearlson, C Nagoshi, ED London (1988): Brain structural abnormalities differentially correlate with severity of alcohol and opioid abuse. NIDA Res. Monogr. 90: 374. SB Waller, MJ Ball, ED London (1989): The neocortical and hippocampal cholinergic nervous systems in dementia: a neurochemical examination. Am. Gerontol. Soc., Nov 18-22, San Francisco. ED London, JH Jaffe, NG Cascella, M Sano, RI Herning, J Links, D Wong, RF Dannals, R Grayson, HN Wagner Jr. (1988): Acute cocaine decreases regional cerebral glucose utilization in human substance abusers. 29th Ann. Meeting Am. Coll. Neuropsychopharmacol. Dec 11-16, San Juan, PR. C Ori, ED London (1988): Effetto degli anestetici inalatori protossido d'azoto e alotano sul sottotipo kappa dei recettori degli oppioidi. XLII Congresso Nazionale SIAARTI Oct 20-23, Sorrento. A Della Puppa, AS Kimes, T Vu, ED London (1989): Cerebral metabolic mapping of the effects of agonists and antagonists for binding sites. Brain 89, ed. by C Fieschi, GL Lenzi. Proc. XIVth Int. Symp. Cerebral Blood Flow and Metabolism. Bologna, Italy, Raven Press, New York. FY Ford-Rice, MD Majewska, ED London (1989): Effects of in vivo steroid hormone treatment on sigma receptor binding in the female rat brain. Soc. Neurosci. Abstr.15: 1216. 43

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GR Hill, A della Puppa, ED London (1989): Effects of high-dose d-SKF 10047 on cerebral metabolism in rats. Soc. Neurosci. Abstr. 15:858. DF Wong, D Young, LT Young, LE Tune, G Pearlson, E Minkin, C Cidis Meltzer, K Midha, RF Dannals, HT Ravert, AA Wilson, ED London, HN Wagner Jr., M Casanova, J Kleinman, MJ Kuhar, A Gjedde (1989): Validation of PET D2 dopamine receptor quantification using [11C]NMSP and 18 [ F]haloperidol. Soc. Neurosci. Abstr. 15:1123. S Demirgören, MD Majewska, HN Wagner, ED London (1989): Binding of pregnenolone sulfate to rat brain membranes: interaction with the GABAA receptor complex. Soc. Neurosci. Abstr. 15:994. AS Kimes, G Szabo, ED London, L Raymon, B Tabakoff (1989): Metabolic effects of GP120 in brain regions rich in VIP receptors. Soc. Neurosci. Abstr. 15:381. ED London, MD Majewska (1989): Binding of [3H]-mecamylamine to the nicotinic receptor complex in the rat brain: modulation by ATP. Soc. Neurosci. Abstr. 15:64. H Takayama, MD Majewska, ED London (1989): ATP: An allosteric modulator of the nicotinic receptor in brain. Soc. Neurosci. Abstr. 15:64. MD Majewska, JMH ffrench-Mullen, ED London (1989): Ascorbic acid and glutathione are antagonists of the NMDA receptor. Soc. Neurosci. Abstr. 15:1167. A della Puppa, ED London (1989): Cerebral metabolic effects of sigma ligands in the rat. Soc. Neurosci. Abstr. 15:857. NG Cascella, ED London, M Sano, DF Wong, RI Herning, JM Links (1989): Acute cocaine reduces brain glucose metabolism in drug users. Am. Psychiatric Assoc. May 6-12 San Francisco, CA. 3

ED London, H Takayama, M Majewska (1989): [ H]Mecamylamine binding to the nicotinic receptor complex in the rat brain: Modulation by ATP. Am. Coll. Neuropsychopharm., Dec 9-16, Maui, HI. MD Majewska, JR ffrench-Mullen, ED London (1989): Ascorbic acid and glutathione are allosteric antagonists of the NMDA receptor. Am. College Neuropsychopharmacol., Dec 9-16, Maui, HI. ED London, NG Cascella, DF Wong, RF Dannals, JH Jaffe, HN Wagner Jr. (1989): Decrease in brain glucose utilization by cocaine. Am. Psychiatric Assoc., May 12-17, 1990, New York, NY. ED London, EP Broussolle, JM Links, D Wong, H Wagner, JH Jaffe (1990): Decreased brain glucose utilization by morphine. Am. Psychiatric Assoc., May 12-17, New York, NY. 3

X-Z Wu, JA Bell, CE Spivak, ED London, T-P Su (1990): Sigma ligand [ H]-d-SKF-10047 labelled two types of binding sites in intact NCB-20 Cells. FASEB J. 4:A329. MJ Morgan, NG Cascella, JM Stapleton, EK Shaya, DF Wong, ED London (1990): Relationship between ventricle/brain ratio, a measure of cerebral atrophy and subjective responses to intravenous cocaine in human substance abusers. Soc. Neurosci. Abstr. 16:582. LP Raymon, AS Kimes, LT Meltzer, TG Heffner, ED London (1990): Effects of CI-943, A potential antipsychotic agent, on cerebral glucose utilization in rats. Soc. Neurosci. Abstr. 16:250. DB Vaupel, A della Puppa, WR Lange, ED London (1990): Verapamil reduces hypercapnia and euphoria produced by morphine in humans. Soc. Neurosci. Abstr. 16:928. MD Majewska, JA Bell, ED London (1990): Redox phenomena modulate function of the NMDA receptor. Soc. Neurosci. Abstr. 16:464. S Demirgören, MD Majewska, ED London (1990): Dehydroepiandrosterone sulfate, a neurosteroid, binds to rat brain membranes and modulates the function of GABA-A receptors. Soc. Neurosci. Abstr. 16:691. 44

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CR Mantione, S Demirgören, ED London (1990): Polyamine binding sites on synaptosomal membranes. Soc. Neurosci. Abstr. 16:540. AS Kimes, DF Wong, ED London (1990): Use of mecamylamine (MEC) and lobeline (LOB) to estimate nonspecific binding of radiolabeled nicotine (NIC) in vivo. Soc. Neurosci. Abstr. 16:684. DF Wong, R Gibson, ED London, HD Burns, E Shaya, R Dannals, H Ravert, AA Wilson, HN Wagner Jr. (1990): In vivo studies of receptors with radiolabeled haloperidol. Soc. Neurosci. Abstr. 16:1140. ED London, NG Cascella, JS Stapleton, R Phillips, M Morgan, DF Wong (1991): Brain metabolism and drug-induced euphoria. Am. Psychiat. Assoc., May 11-16, New Orleans. ED London (1990): Acute effects of cocaine on cerebral glucose metabolism in substance abusers. Am. Coll. Neuropsychopharmacol., Dec 9-14, San Juan, PR. ED London (1990): Sigma receptor deficits in schizophrenia: Postmortem studies suggest a potential for PET diagnosis. Am. Coll. Neuropsychopharmacol., Dec 9-14, San Juan, PR. ED London, CR Mantione (1991): Ligand-binding studies of polyamine receptors in the brain. IBRO Third World Congress Workshop Montreal, Canada (unpublished abstract). BCK Yung, J Stapleton, R Phillips, M Morgan, NG Cascella, JH Jaffe, DF Wong, ED London (1991): Subjective responses to cocaine and brain metabolism. J. Cerebral Blood Flow Metab. 11:S392. JM Stapleton, BCK Yung, ML Spurgeon, MJ Morgan, R Phillips, N Cascella, JH Jaffe, DF Wong, ED London (1991): Brain metabolism and psychological parameters in substance abusers. J. Cereb. Blood Flow Metab. 11:391. RI Herning, BJ Glover, B Koeppl, R Reddish, ED London (1991): Effects of cocaine withdrawal on the CNS: EEG, evoked potential and performance measures. Biol. Psychiatry 29:191. DF Wong, R Gibson, HD Burns, RF Dannals, E Shaya, ED London, N Brenner, AA Wilson, HT Ravert, C Chen, E Minkin, HN Wagner, Jr. (1991): In vivo imaging of sigma receptors in primate brain. J. Nucl. Med. 32:1071. ED London, JM Stapleton, BCK Yung, RL Phillips, MJ Morgan, NG Cascella, DF Wong, JH Jaffe (1991): Effects of acute cocaine on cerebral glucose utilization in human polydrug abusers: relations between regional metabolism and subjective responses. NIDA Res. Monogr. 119:220. ED London, J Stapleton, B Yung, RL Phillips, MJ Morgan, NG Cascella, DF Wong, JH Jaffe (1991): Effects of intravenous cocaine on cerebral glucose utilization in human polydrug abusers: relations between regional metabolism and subjective responses. Symposium on Nuclear Imaging in Drug Discovery, Development and Approval, Jun 17-19, Baltimore, MD. JM Stapleton, BCK Yung, ML Spurgeon, MJ Morgan, RL Phillips, NG Cascella, JH Jaffe, DF Wong (1991): Personality characteristics in substance abuse and relationship to physiological parameters in human subjects. Am. Psychol. Assoc. Ann. Meeting Aug 16-20, San Francisco, CA (unpublished). P Garofalo, D Ingram, E Spangler, I Odano, CR Mantione, ED London (1991): Possible interaction of cholinergic and glutaminergic systems in age-associated memory impairment. 4th Int. Cong. Int. Assoc. Biomed. Gerontol, Jun 26-29, Ancona, Italy, (unpublished abstract). VL Dawson, TM Dawson, ED London, DS Bredt, SH Snyder (1991): Glutamate neurotoxicity is mediated by nitric oxide. Soc. Neurosci. Abstr. 17:7 DK Ingram, P Garofalo, EL Spangler, C Mantione, I Odano, ED London (1991): Aging Increases dizocilpine-induced learning impairment and decreases hippocampal and striatal NMDA receptor concentrations in rats. Soc. Neurosci. Abstr. 17:368. RD Kusztos, CR Mantione, ED London (1991): Interactions of polyamines with the nicotinic acetylcholine receptor in rat brain. Soc. Neurosci. Abstr. 17:1524. 45

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AS Kimes, DB Vaupel, M Bruckner, ED London (1991): Nitroarginine, a nitric oxide synthase inhibitor, attenuates morphine withdrawal. Soc. Neurosci. Abstr. 17:538. ED London, CR Mantione (1991): Ligand-binding studies of polyamine receptors in rat brain. Third French-U.S. Seminar Multiple Sigma and PCP Receptor Ligands: Mechanisms for Neuromodulation and Protection, Sept. , Montpellier, France (unpublished abstract). CR Mantione, VL Dawson, ED London (1991): [3H]Spermidine labels multiple polyamine receptor sites in brain. Trans. Am. Soc. Neurochem. 22:222. AS Kimes, B Hope, K Rasmussen, ED London (1992): Opioid withdrawal, from DNA to the human addict. Winter Conf. on Brain Res. Steamboat Springs, CO (unpublished abstract). ED London (1991): Steroid binding at σ receptors: A link between the brain and the endocrine and immune systems. Colloquium on Ageing, Istituto Scientifico Roussel Italia, Oct 24-25, Rome, Italy. ED London (1991): Imaging with positron emission tomography to investigate drug action. Am. College of Neuropsychopharmacol. Dec 9-13, San Juan, PR. ED London, EB de Souza, SW Tam, WD Bowen, AS Basile (1991): Sigma Receptors: Biochemistry, physiology and clinical potential. Am. Coll. Neuropsychopharmacol. Dec 9-13, San Juan, PR. JM Stapleton, ML Spurgeon, M Morgan, B Yung, RL Phillips, NG Cascella, JH Jaffe, DF Wong, ED London (1991): Psychological characteristics and cerebral glucose metabolism in substance abusers & control subjects. Am. Coll. Neuropsychopharm. Ann. Mtg., Dec 9-13, San Juan, PR. ED London (1992): Effects of acute exposure to drugs of abuse on regional brain metabolism. Am. Coll. Nuclear Physicians 18th Ann. Meeting, San Diego CA, Mar 1-5. DB Newlin, CJ Wong, RP Waits, JM Stapleton, ED London (1992): Tachycardia from i.v. nicotine is mediated vagally in human subjects. Coll. Problems Drug Depend., Jun. 20-25, Keystone, CO. J Stapleton, J Henningfield, DF Wong, R Phillips, R Grayson, R Dannals, ED London (1993): Nicotine reduces cerebral glucose utilization in humans. NIDA Res. Monogr. 132:106. JI Szekely, ED London (1992): Drug addiction and functional preponderance of the kappa opioid system: A hypothesis. Coll. Problems Drug Dependence, Jun 20-25, Keystone, CO. AS Kimes, ED London (1992): Attenuation of opioid withdrawal by inhibitors of nitric oxide synthase. Pharmacologist 34:209. SL Walsh, JM Stapleton, KL Preston, JT Sullivan, RF Dannals, RF Grayson, RL Phillips, GE Bigelow, DR Jasinski, ED London (1992): Acute effects of buprenorphine on cerebral glucose utilization in human substance abusers. Soc. Neurosci. Abstr. 18:371. 3

RD Kusztos, D Ingram, J Joseph, EL Spangler, ED London (1992): [ H]CGS 19755 binding to NMDA receptors in rat hippocampus: Effects of age and chronic nimodipine. Soc. Neurosci. Abstr. 18:1435. K Hashimoto, CR Mantione, M Spada, JL Neumeyer, ED London (1992): Subcellular distribution of [3H] ifenprodil binding in rat brain. Soc. Neurosci. Abstr. 18:1155. DB Vaupel, WR Lange, ED London (1992): Verapamil potentiates morphine analgesia and reduces euphoria in humans. Soc. Neurosci. Abstr. 18:687. JM Stapleton, JE Henningfield, DF Wong, RL Phillips, SF Gilson, RF Grayson, FR Dannals, ED London (1992): Effects of nicotine on cerebral metabolism and subjective responses in human volunteers. Soc. Neurosci. Abstr. 18:1074. DK Ingram, E Spangler, D Roberts, S Iijima, ED London (1992): Nitric oxide synthase inhibition by Nw-nitro-l-arginine impairs learning of rats in a 14-unit t-maze. Soc. Neurosci. Abstr. 18:1220. 46

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DL Frankenfield, JM Stapleton, R Stauffer, ED London, WR Lange (1992): Profound bradyarrhythmia following nicotine administration. 27th Ann. ASHP Midyear Clin. Meeting Dec 6-10, Orlando, FL. RL Phillips, C Chen, DF Wong, JM Stapleton, ED London (1993): Modeling the plasma cerebral metabolic rate for glucose. Soc. Nucl. Med. 34:40P J Flesher, U Scheffel, ED London, JJ Frost (1993): In vivo labeling of nicotinic cholinergic receptors in brain using [H-3]cytisine. Soc. Nucl. Med. 34:199P. X Liu, R Phillips, D Wong, RN Bryan, ED London (1993): Brain structure and neuropsychological performance of substance abusers: preliminary magnetic resonance imaging study. Abstr. Soc. Neurosci. 19:380. AS Kimes, R Maldonado, GF Koob, E Ambrosio, ED London (1993): Injections of methylnaloxonium into the locus coeruleus produce cerebral hypermetabolism in morphine-dependent rats. Abstr. Soc. Neurosci. 19:1022. 3

K Hashimoto, ED London (1993): Characterization of [ H] 4-phenyl-1-(4-phenylbutyl)-piperidine binding in rat brain: Abstr. Soc. Neurosci. 19:1155. DK Ingram, E Spangler, D Roberts, H Kametani, ED London (1993): Intraventricular injection of Nω-nitro-L-arginine impairs learning of rats in a 14-unit t-maze. Abstr. Soc. Neurosci. 19:1390. A Mukhin, E Kovaleva, ED London (1993): Effect of mono-, di- and polyvalent cations on NMDA 3 sensitive [ H]CGP-39653 binding in rat brain membranes. Abstr Soc. Neurosci.. 19:1784. 3

K Hashimoto, ED London (1993): Further characterization of [ H]ifenprodil binding to sigma sites. J. Cereb. Blood Flow Metab. 13 (Suppl). 630. ED London (1993): Drug effects on cerebral metabolism and blood flow. Am. Psychiatric Assoc., May 21-26, 1994, Philadelphia, PA ED London (1993): Brain metabolism in substance abusers. Am. Psychiatric Assoc. May 21-26, 1994, Philadelphia, PA. K Hashimoto, ED London (1993): Further characterization of [3H]ifenprodil binding to sigma sites. XVIth Int’l Symposium on Cerebral Blood Flow & Metab. May 22-28, Sendai, Japan. DB Vaupel, WR Lange, ED London (1993): Verapamil potentiates morphine analgesia and reduces euphoria in humans. Coll. Problems of Drug Dependence, Jun 12-17, Toronto, Canada. VL Villemagne, S Gilson, AS Kimes, RL Phillips, DF Wong, X Liu, P Bridge, PJ Harris, RF Dannals, M Ruff, C Pert, HN Wagner Jr., ED London (1994): Effects of peptide T on cerebral glucose metabolism in AIDS dementia complex (ADC) studied by positron emission tomography (PET) and [F-18]FDG. Soc. Nucl. Med. 35S: 118P DB Vaupel, WR Lange, ED London (1994): Verapamil potentiates morphine analgesia and reduces euphoria in human subjects. NIDA Res. Monogr. 141:80. ED London, DB Vaupel, AS Kimes (1994): Inhibitors of nitric oxide synthase as potential treatments for opioid withdrawal. Regul. Pept. 54:165. T Matsunaga, A Mukhin, ED London (1994): NMDA receptor domains: Regional variation in the densities and proportions of binding sites. Soc. Neurosci. Abstr. 20:491. A Shimada, EL Spangler, ED London, DK Ingram (1994): Spermidine potentiates dizocilpineinduced learning impairment in a 14-unit T-maze to demonstrate polyamine modulation of NMDA receptor. Soc. Neurosci. Abstr. 20:1019.

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AS Kimes, DB Vaupel, ED London (1994): Comparison of the attenuation of the opioid withdrawal syndrome by 7-nitroindazole, a brain-specific nitric oxide synthase inhibitor, with that of other nitric oxide synthase inhibitors. Soc. Neurosci. Abstr. 20:1675. ED London, AG Mukhin (1994): Polyamines as endogenous modulators of NMDA receptor and other ligand-gated ion channels. NY Acad. Sci., May 25-28, 1994, Washington, DC. AG Mukhin, T Matsunaga, ED London (1994): Effect of anions on [3H]CGP 39653 binding to NMDA receptors in brain. XIXth Coll. Int. Neuro-Psychopharm. Jun 27-Jul 1, Washington, DC. AS Kimes, DB Vaupel, ED London (1994): Comparison of the attenuation of opioid withdrawal by nitric oxide synthase inhibitors. IUPHAR Symposium, “Nitric Oxide in the Nervous System”, Jul. 2224, Montreal, Canada. H Takahashi, JR Kirsch, K Hashimoto, ED London, RC Kohler, RJ Traystman (1994): PPBP [4Phenyl-l-(4-phenylbutyl)piperidine], a potent σ-receptor ligand, decreases brain injury following transient focal ischemia in cats. Am. Soc. Anesthesiol. Oct 15-19, San Francisco, CA. S Grant, D Newlin, V Villemagne, RL Phillips, X Liu, AS Kimes, T Matsunaga, C Contoreggi, A Margolin, ED London (1994): Cerebral glucose metabolism during cocaine craving: A PET FDG study. Am. Coll. of Neuropsychopharmacology, Dec 12-16, San Juan, PR. B Vaupel, AS Kimes, and ED London (1995): Attenuation of opioid withdrawal: pharmacological profiles of nitric oxide synthase inhibitors. NIDA Res. Monogr. 153:103. X Liu, RL Phillips, SM Resnick, DF Wong, JM Stapleton, VL Villemagne, ED London (1995): Volume of lateral ventricles in polysubstance abusers: A nuclear magnetic resonance imaging study. NIDA Res. Monogr. 153:209. S Grant, D Newlin, VL Villemagne, RL Phillips, X Liu, AS Kimes, T Matsunaga, C Contoreggi, ED London (1995): Cocaine craving: a PET FDG study. Soc. Nucl. Med. 36:43P. Jun 15, Mpls., MN. R Phillips, J Links, A Kimes, S Grant, E London (1995): Modeling FDG concentration in venous plasma to assay cerebral gluclose metabolism by PET. Soc. Nucl. Med. 36:82P. Jun 15, Mpls., MN. U Scheffel, K Kellar, A Kimes, M Kuhar, ED London (1995): In vivo labeling of nicotinic cholinergic receptors in brain using [H-3]epibatidine. Soc. Nucl. Med. 36:253P. Jun 15, Mpls., MN. U Scheffel, FI Carroll, J Kepler, GF Taylor, M Stathis, ED London (1995): In vivo labeling of nicotinic acetylcholine receptors with (+)- & (-)H-3-norchloro-epibatidine. Soc. Nucl. Med. 36:253P. Jun. 15, Mpls., MN. AS Kimes, U Scheffel, KJ Kellar, ED London (1995): Radiolabeled epibatidine: Promising ligand for in vivo imaging of central nicotinic acetylcholine receptors. Soc. Neurosci. Abstr. 21:10. S Pögun, E Koylu, S Demirgören, ED London (1995): Gender differences in neuronal nicotinic receptors and the effects of chronic nicotine administration & nicotine withdrawal in rats. Soc. Neurosci. Abstr. 21:11.

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H Takahashi, JR Kirsch, K Hashimoto, ED London, RJ Traystman (1995): The sigma ligand (+)pentazocine decreases brain injury following transient focal ischemia in rat. 21st Int. Joint Conf. on Stroke and Cerebral Circulation. Jan 25-27, San Antonio, TX. H Takahashi, JR Kirsch, K Hashimoto, ED London, RC Koehler, RJ Traystman (1995): A sigmareceptor ligand decreases brain injury following transient focal ischemia in cat. 20th Int. Joint Conf. on Stroke and Cerebral Circulation Feb 9-11, Charleston, SC. S Grant, D Newlin, V Villemagne, RL Phillips, X Liu, AS Kimes, T Matsunaga, C Contoreggi, A Margolin, ED London (1995): Stimulation of regional cerebral glucose metabolism by cocainerelated cues: A brain imaging study. Coll. Problems Drug Dependence, Jun 10-15, Scottsdale, AZ. RL Phillips, JM Links, ED London (1995): Modeling the concentration of FDG in arterial plasma to calculate cerebral glucose metabolism by single- and multi-scan methods. XVIIth Int’l Symp. on Cerebral Blood Flow and Metabolism, BRAIN 95 Jul 2-6, Cologne, GE. H Takahashi, J Kirsch, K Hashimoto, ED London, RJ Traystman (1995): PPBP [4-phenyl-1-(4phenylbutyl)piperidine], a potent σ receptor ligand, decreases brain injury following transient focal ischemia in rats. Ann. Am. Assoc. Anesthesiol. Oct 21-25, Atlanta, GA. X Liu, M Takagishi, SM Resnick, JL Cadet, RN Bryan, DF Wong, ED London (1996): Regional cerebral volumes and asymmetries in polydrug abusers: A volumetric magnetic resonance imaging study. NIDA Res. Monogr. 162:196. JL Musachio, U Scheffel, M Stathis, V Villemagne, P Finley, A Horti, AS Kimes, ED London, M Davila-Garcia, KJ Kellar, RF Dannals (1996): Synthesis of [I-125/I-123]-IPH: A radiolabeled analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors. J. Nucl. Med. 37:6P. VL Villemagne, A Horti, U Scheffel, HT Ravert, P Finley, ED London, RF Dannals (1996): Imaging nicotinic acetylcholine receptors in baboon brain by PET. J. Nucl. Med. 37:192P. AG Horti, HT Ravert, WB Mathews, JL Musachio, A Kimes, ED London, RF Dannals (1996): Synthesis of high specific activity carbon-11 N-methylated analogs of epibatidine for imaging. J. Nucl. Med. 37:192P. DB Vaupel, AS Kimes, ED London (1996): Inhibition of constitutive but not inducible nitric oxide synthase attenuates signs of morphine withdrawal. Soc. Neurosci. Abstr. 22:1162. M Takagishi, AS Kimes, ED London (1996): Effects of low dose mecamylamine on regional cerebral glucose metabolism in rats receiving chronic nicotine. Soc. Neurosci. Abstr. 22:165. FJ Vocci, ED London (1996): Assessment of neurotoxicity caused by drugs of abuse and potential treatment agents. Current and Emerging Technologies in Monitoring Brain Structure and Function, Mar 28-29, Bethesda, MD (unpublished abstract). S Grant, D Newlin, V Villemagne, R Phillips, X Liu, A Kimes, C Contoreggi, A Margolin, ED London (1996): Activation of a cortical memory circuit is related to cue-elicited cocaine craving: A positron emission tomographic study. Cognitive Neurosci. Soc., Mar 31 - Apr 2, San Francisco, CA. E London, S Grant, D Newlin, V Villemagne, RL Phillips, X Liu, AS Kimes, C Contoreggi, A Margolin (1995): Cocaine-related cues elicit craving and activate cortical circuits relevant to episodic memory. Soc. Biol. Psychiatry, 51st Ann. Convention & Sci. Prog., May 1-5, 1996, New York, NY. F Yokoi, P Finley, M Stathis, A Chen, M Master, U Scheffel, E London, D Wong (1996): Effects of saffan & isoflurane on [3H]raclopride and [3H]NMSP binding in mouse brain. Soc. Nucl. Med., Jun. 3-6, Denver, CO.

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