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Home > Journals > Applied Physiology, Nutrition, and Metabolism > List of Issues > Volume 34, Number 5, October 2009 > Experimental and clinical research findings on the cardiovascular bene...
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Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed
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Chantal M.C. Bassett,a Delfin Rodriguez-Leyva,b Grant N. Pierce a
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a Institute of Cardiovascular Sciences, St Boniface Hospital Research
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b Cardiovascular Research Division, V.I. Lenin University Hospital, Holguin, Cuba.
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Published on the web 18 September 2009.
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Received October 6, 2008. Accepted June 13, 2009.
Journal Tools Applied Physiology, Nutrition, and Metabolism, 2009, 34(5): 965-974, https://doi.org/10.1139/H09-087 Instructions to authors
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Centre and the Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, MB R2H 2A6, Canada. Browse the journal
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Functional foods and nutraceuticals are becoming popular alternatives to pharmacological treatments by providing health benefits and (or) reducing the risk of chronic diseases. Flaxseed is a rich source of 3 components with demonstrated cardioprotective effects: the omega-3 fatty acid -linolenic acid (ALA), dietary fibre, and phytoestrogen lignans. Multiple clinical dietary intervention trials report that consuming flaxseed daily can modestly reduce circulating total cholesterol (TC) by 6%–11% and low-density lipoprotein (LDL) cholesterol by 9%–18% in normolipemic humans and by 5%–17% for TC and 4%–10% for LDL cholesterol in hypercholesterolemic patients, as well as lower various markers associated with atherosclerotic cardiovascular disease in humans. Evidence to date suggests that the dietary fibre and (or) lignan content of flaxseed provides the hypocholesterolemic action. The omega-3 ALA found in the flaxseed oil fraction also contributes to the antiatherogenic effects of flaxseed via antiinflammatory and antiproliferative mechanisms. Dietary flaxseed may also protect against ischemic heart disease by improving vascular relaxation responses and by inhibiting the incidence of ventricular fibrillation.
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Keywords: flaxseed, linseed, heart disease, nutrition
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