Idea Transcript
G 1
F
Apr. 2503
No. 54
CONTENTS From the Editor-in-Chief.. ........................................................................................ Notice to contributors.. ............................................................................................ ARTICLES Cyclophosphamide therapy: A retrospective review of 4 1 cases of Lupus Nephritis Dr Go Kuan Weng & Dr Teo Sue Mei.. ........................................................................... In Search of the Ideal "Fat Combo" for Cardiovascular Health Dr. Tony Ng Kock Wai............................................................................................... Filariasis in Pahang: Towards Elimination Mohamed Sapian M, Masran. M, Abdul Rahim A., Siti Zubaidah AR, Marlia MS, Sarah Y.. .............. Situational Analysis of Ambulance Usage in Hospital Tapah (8 Years Analysis). K. K. Murth, Omar S.A, Sukdershan S. ............................................................................. Management of Severe Laryngomalacia in Otorhinolaryngology Department of Hospital Melaka Abdul Razak, S. Subramaniaan, Mohamed Khir A.. ............................................................ A Review of Tuberculosis Incidence in Kinta District Noridah 0,Hairul Izwan AR, Hazlee AH.. .......................................................................
Why do we need a Healthy Workplace? Dr Leela Anthony & Dr Arumugam Lingam.S.. ................................................................. PUBLISHED ABSTRACTS
contamination of breast milk obtained by manual expression and breast pumps in mothers of very low birth weight infants N. Y. Boo, A.J. Nordiah, H. AIJizah, A.H. Nor-Rohani & V.K.E. Lim .......................................... Potential larvicides from Malaysian plants Ee G. C.L., Lim C.K., Cheow Y.L., Kamanrlzaman N. H., Taufig Yap Y.H , Ramli I. & Lee H. L.. ................................................................................................. Borrelia burgdorferi (strain 6. aJielii) antibodies among Malaysian blood donors and patients S. T. Tay, M. Kamalanathan & M. Y. Rohani.. ...................................................................
Isolation and PCR detection of rickettsiae fiom clinical and rodent samples in Malaysia S. T. Tay, M. Y. Rohani, T.M. Ho and S. Devi.. .................................................................. An unusual mutation in RECQ4 gene leading to Rothmund-Thomson syndrome Pauline Balraj, Pat Concannon, Rahman Jamal, Alessandro Beghini, T.S. Hoe, Alan Soobeng Khoo & Ludovica Volpi..................................................................................................... Laboratory evaluation of three herbal repellents against mosquitoes of public health importance in Malaysia Latipah Omar & I. Vythilingam.....................................................................................
Type of diabetes and waist-hip ratio are important determinants of serum lipoprotein (a) levels in diabetic patients Hapizah M Nawawi, Musilawati Muhajir, Yeo Chee Kian, Wan Nazaimoon Wan Mohamud, Khalid Yusog B.A. K. Khalid.. .............................................................................................. Staphylococcus aureus cairiage in selected communities and their antibiotic susceptibility patterns A. Norazah, V.K.E. Lim, S.N. Munirah, A.G. M. Kamel.. ....................................................... HIV infection among fishermen in Terengganu Fauziah M.N., Anita S., Shaari N., Ahamad J., Pratap Senan & Muhammad Amir K.. ....................
Increasing genetic diversity of Salmonella enterica Serovar Typhi isolates from Papua New Guinea over the Period from 1992 to 1 999 Kwai-Lin Thong, Yee-Ling Goh, Rohani M. Yasin, Ming Guek Lau, Megan Pmsey, Gibson Winston, Mition Yoannes, Tikki Pang & John C. Reeder.. ................................................................ The prevalence of Anopheles (Diptera:Culicidae) mosquitoes in Sekong Province, Lao PDR: In relation to malaria transmission I. Vythilingam, R Phetsouvanh, K. Keokenchanh, V. Yengmala, V. Vanismeth, S. Phompida and S. Lokman Hakim.. ...................................................................................................... Genetic diversity of clinical cand environmental strains of Salmonella enterica serotype weltevreden isolated in Malaysia K. L. Thong, Y.L. Goh, S. Radu, S. Noorzaleha, R. Yassin, K T. Koh, V.K. E. Lim, G. Rusul & S.D. Puthucheary...................................................................................................... Durability of Red Blood Cells to Lipid Peroxidation in Haemodialysis Patients A.S. Santhana Raj a4 Louis Masalamany.. ....................................................................... REPORTS
Kajian Anemia di antara Ibu-ibu pada 36 Minggu Kehamilan di Daerah Sik Kedah Chelladurai E, Habsoh H & Rosmiah M. ......................................................................... IMR AVTlVlTlES
Laporan Mengenai Unit Mikroskopi Elektron Pusat Surnber Penyelidikan Perubatan, IMR.. ............. EDITORIAL BOARD
49
IMR Quarterly Bulletin No. 54: Apr. 2003
From the Editor-in-Chief
This is the 54" Issue of the IMR Quarterly Bulletin for the 2"* Quarter of 2003. We are grateful to many contributors who have made the 54" issue a success. The contents of the bulletin will continue to include original research articles, reports, and abstracts of published scientific papers as well as calendar of events of research interests. From the Editor's desk I would like to highlight the importance of emerging diseases such as the 'Severe Acute Respiratory Syndrome (SARS)' which has had such a tremendous effect on global public health in such a short span of time. For the first time in recent history, people from all walks of life stood still to take note of a disease, an unseen pathogen, which threatened their very existence. Our closest neighbour, Singapore faced the brunt of the disease in our region. In order to contain future outbreaks and protect health workers, a special panel of foreign and local experts has developed a document on 'Biosafety and SARS Incident in Singapore September 2003' (Director of Medical Services, Epidemiology and Disease Control, Ministry of Health, Singapore). This will be a good source of information on biosafety for those involved in public health activities. The report highlights a large range of biosafety structures and practices that are essential for laboratories, laboratory workers, health workers, scientists and students.
Notice to Contributors
The article should have the following sections: Brief Abstract, Introduction; Materials and methods; Results; Discussion; Acknowledgements and References. Illustrations should be drawn clearly and not photocopied. Care should be taken that illustrations do not exceed a maximum size of 12.0 x 18.5cm. The Editorial Board reserves the right to arrange drawings and photographs in a manner so as to make a composite plate to avoid undue wastage of space. References should be given in alphabetical order with the full title of the journal. The articles can be written in Bahasa Malaysia or in English with double spacing and submitted as a typescript, on size A4 paper to Pn. Siti Rodziah, Unit Perpustakaan, Maklumat dm Penerbitan, Institute Penyelidikan Perubatan or transmitted electronically to the following e-mail address: rodziah@imr.~ov.m~ It is assumed that all articles submitted for publication have the prior approval of their respective Directors. The Editorial Board takes no responsibility for the accuracy of statements made by the author(s) and the views expressed in the articles are not to be taken as that of the Institute for Medical Research or the Ministry of Health Malaysia.
ARTICLES
IMR Quarterly Bulletin No. 54: Apr. 2003
Cyclophosphamide therapy: A retrospective review of 41 cases of Lupus Nephritis.
Go Kuan Weng, Teo Sue Mei Clinical Specialis in Nephrology, Nephrology Unit, Hospital Ipoh, Jalan Hospital, 30990 Ipoh, Perak. Abstract OBJECTIVES: To analyze the treatment and renal outcome of patient with lupus nephritis (LN) WHO class 111 and IV on cyclophospharnide (CYC). PATIENTS AND METHODS: A retrospective study of patients with biopsy-proven LN who were given oral or intravenous CYC. RESULTS: 41 patients with a male: female ratio of 4:37; comprising of 36 cases (87.8%) of WHO class IV and 5 cases (12.2%) of WHO class I11 LN. Mean age at presentation was 31.7 9.8 years with mean serum creatinine of 87.4 37.2 pmoVL and mean follow-up of 84 & 78 months. A total of 30 patients (73.2%) completed 12 courses of IV CYC and one patient (2.4%) completed three months of oral CYC with complete response (CR) rate of 71.0% (n=22), partial response rate of 25.8% (n=8) and no response (NR) rate of 3.2% (n=l). Of the remaining 11 patients, two patients (4.9%) died during treatment, three patients (7.3%) defaulted treatment and five patients (12.2%) still receiving on-going treatment. Presence of hypertension (p