International Journal of Chronic Obstructive Pulmonary Disease [PDF]

Increased risk of community-acquired pneumonia in COPD patients with comorbid cardiovascular disease. Lin SH, Perng DW,

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ORIGINAL RESEARCH

Randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of three doses of co-suspension delivery technology glycopyrronium MDI in Japanese patients with moderate-to-severe COPD

Open access peer-reviewed

Fukushima Y, Nakatani Y, Ide Y, Sekino H, St Rose E, Siddiqui S, Maes A, Reisner C

scientific and medical journals.

International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1187-1194

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Published Date: 13 April 2018

ORIGINAL RESEARCH

Open Access

The association of neuron-derived orphan receptor 1 with pulmonary vascular remodeling in COPD patients

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Wang CG, Li C, Lei W, Jiang JH, Huang JA, Zeng DX

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International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1177-1186

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Published Date: 13 April 2018

ORIGINAL RESEARCH

Bulk reprints for the

The link between chronic obstructive pulmonary disease phenotypes and histological subtypes of lung cancer: a case–control study

pharmaceutical industry.

Wang W, Xie M, Dou S, Cui L, Zheng CY, Xiao W

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International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1167-1175

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Published Date: 13 April 2018

COMMENTARY

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Chest pain in patients with COPD: the fascia’s subtle silence

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International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1157-1165

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Published Date: 12 April 2018

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ORIGINAL RESEARCH

Critical regulation of inflammation via class A scavenger receptor Xie L, Li Q, Dong R, Zhao K, Feng Y, Bao Z, Zhou M International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1145-1155 Published Date: 13 April 2018

ORIGINAL RESEARCH

Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline Lo CY, Huang HY, He JR, Huang TT, Heh CC, Sheng TF, Chung KF, Kuo HP, Wang CH International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1135-1144 Published Date: 11 April 2018

ORIGINAL RESEARCH

Exacerbation heterogeneity in COPD: subgroup analyses from the FLAME study Vogelmeier CF, Chapman KR, Miravitlles M, Roche N, Vestbo J, Thach C, Banerji D, Fogel R, Patalano F, Olsson P, Kostikas K, Wedzicha JA International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1125-1134 Published Date: 10 April 2018

ORIGINAL RESEARCH

Geographic variations of the prevalence and distribution of COPD phenotypes in Spain: “the ESPIRAL-ES study” Alcázar-Navarrete B, Trigueros JA, Riesco JA, Campuzano A, Pérez J International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1115-1124 Published Date: 10 April 2018

ORIGINAL RESEARCH

Prediction of severe exacerbations and mortality in COPD: the role of exacerbation history and inspiratory capacity/total lung capacity ratio Cardoso J, Coelho R, Rocha C, Coelho C, Semedo L, Bugalho Almeida A International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1105-1113 Published Date: 5 April 2018

REVIEW

Practical considerations when prescribing a long-acting muscarinic antagonist for patients with COPD D’Urzo AD, Kardos P, Wiseman R International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1089-1104 Published Date: 4 April 2018

ORIGINAL RESEARCH

Cost-effectiveness analysis of a fixed-dose combination of indacaterol and glycopyrronium as maintenance treatment for COPD Chan M, Tan ECH, Yang MC International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1079-1088 Published Date: 4 April 2018

ORIGINAL RESEARCH

Description of nighttime cough epochs in patients with stable COPD GOLD II–IV Fischer P, Gross V, Kroenig J, Weissflog A, Hildebrandt O, Sohrabi K, Koehler U International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1071-1078 Published Date: 3 April 2018

ORIGINAL RESEARCH

Risk factors for respiratory hospitalizations in a population of patients with a clinical diagnosis of COPD Veljanovski J, Ouellette DR International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1061-1069 Published Date: 28 March 2018

ORIGINAL RESEARCH

Harmful impact of air pollution on severe acute exacerbation of chronic obstructive pulmonary disease: particulate matter is hazardous Choi J, Oh JY, Lee YS, Min KH, Hur GY, Lee SY, Kang KH, Shim JJ International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1053-1059 Published Date: 28 March 2018

ORIGINAL RESEARCH

Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B Brat K, Plutinsky M, Hejduk K, Svoboda M, Popelkova P, Zatloukal J, Volakova E, Fecaninova M, Heribanova L, Koblizek V International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1037-1052 Published Date: 26 March 2018

REVIEW

Support needs of patients with COPD: a systematic literature search and narrative review Gardener AC, Ewing G, Kuhn I, Farquhar M International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1021-1035 Published Date: 26 March 2018

ORIGINAL RESEARCH

The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial Patel NR, Cunoosamy DM, Fagerås M, Taib Z, Asimus S, Hegelund-Myrbäck T, Lundin S, Pardali K, Kurian N, Ersdal E, Kristensson C, Korsback K, Palmér R, Brown MN, Greenaway S, Siew L, Clarke GW, Rennard SI, Make BJ, Wise RA, Jansson P International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1009-1019 Published Date: 27 March 2018

ORIGINAL RESEARCH

Long-term evolution of lung function in individuals with alpha-1 antitrypsin deficiency from the Spanish registry (REDAAT) Esquinas C, Serreri S, Barrecheguren M, Rodríguez E, Nuñez A, Casas-Maldonado F, Blanco I, Pirina P, Lara B, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1001-1007 Published Date: 23 March 2018

ORIGINAL RESEARCH

The effect of electronic cigarette and tobacco smoke exposure on COPD bronchial epithelial cell inflammatory responses Higham A, Bostock D, Booth G, Dungwa JV, Singh D International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:989-1000 Published Date: 23 March 2018

ORIGINAL RESEARCH

Long-term oxygen therapy in COPD patients: population-based cohort study on mortality Pavlov N, Haynes AG, Stucki A, Jüni P, Ott SR International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:979-988 Published Date: 22 March 2018

ORIGINAL RESEARCH

Do patients and carers agree on symptom burden in advanced COPD? Mi E, Mi E, Ewing G, White P, Mahadeva R, Gardener AC, Farquhar M International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:969-977 Published Date: 22 March 2018

ORIGINAL RESEARCH

Cigarette smoke exposure promotes differentiation of CD4+T cells toward Th17 cells by CD40CD40L costimulatory pathway in mice Liang Y, Shen Y, Kuang L, Zhou G, Zhang L, Zhong X, Zhang J, Liu J International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:959-968 Published Date: 21 March 2018

RESEARCH LETTER

A high COPD assessment test score may predict anxiety in COPD Harryanto H, Burrows S, Moodley Y International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:955-957 Published Date: 21 March 2018

ORIGINAL RESEARCH

Pharmacokinetics of glycopyrronium/formoterol fumarate dihydrate delivered via metered dose inhaler using co-suspension delivery technology in patients with moderate-to-very severe COPD Ferguson GT, Rodriguez-Roisin R, Reisner C, Maes A, Siddiqui S, Martin UJ International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:945-953 Published Date: 21 March 2018

ORIGINAL RESEARCH

Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism Shin SH, Kang D, Cho J, Chang H, Kim MS, Lee SY, Lee H, Kim H, Kim DK, Kim EK, Park HY International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:937-943 Published Date: 20 March 2018

ORIGINAL RESEARCH

Maintenance inhaler preference, attribute importance, and satisfaction in prescribing physicians and patients with asthma, COPD, or asthma–COPD overlap syndrome consulting for routine care Ding B, Small M, Scheffel G, Holmgren U International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:927-936 Published Date: 16 March 2018

ORIGINAL RESEARCH

A functional SNP upstream of the ADRB2 gene is associated with COPD Li JX, Fu WP, Zhang J, Zhang XH, Sun C, Dai LM, Zhong L, Yu L, Zhang YP International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:917-925 Published Date: 16 March 2018

ORIGINAL RESEARCH

Comparison of the fixed ratio and the Z-score of FEV1/FVC in the elderly population: a long-term mortality analysis from the Third National Health and Nutritional Examination Survey Oh DK, Baek S, Lee SW, Lee JS, Lee SD, Oh YM International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:903-915 Published Date: 14 March 2018

ORIGINAL RESEARCH

Use of clinical characteristics to predict spirometric classification of obstructive lung disease Pascoe SJ, Wu W, Collison KA, Nelsen LM, Wurst KE, Lee LA International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:889-902 Published Date: 12 March 2018

ORIGINAL RESEARCH

Knowledge and pharmaceutical care practice regarding inhaled therapy among registered and unregistered pharmacists: an urgent need for a patient-oriented health care educational program in Iraq Abdulameer SA International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:879-888 Published Date: 12 March 2018

LETTER

Perspectives on narrative medicine Saberi-Movahed AS, Waqar S, Salha A International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:875-877 Published Date: 9 March 2018

ORIGINAL RESEARCH

Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the risk of pneumonia and severe exacerbations in patients with COPD Lai CC, Wang YH, Wang CY, Wang HC, Yu CJ, Chen L International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:867-874 Published Date: 8 March 2018

ORIGINAL RESEARCH

Excess risk of major vascular diseases associated with airflow obstruction: a 9-year prospective study of 0.5 million Chinese adults Kurmi OP, Li L, Davis KJ, Wang J, Bennett DA, Chan KH, Yang L, Chen Y, Guo Y, Bian Z, Chen J, Wei L, Jin D, Collins R, Peto R, Chen Z International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:855-865 Published Date: 8 March 2018

ORIGINAL RESEARCH

Clinical impact of episodic nocturnal hypercapnia and its treatment with noninvasive positive pressure ventilation in patients with stable advanced COPD Kitajima T, Marumo S, Shima H, Shirata M, Kawashima S, Inoue D, Katayama Y, Itotani R, Sakuramoto M, Fukui M International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:843-853 Published Date: 6 March 2018

CLINICAL TRIAL REPORT

Changes in ventilation–perfusion during and after an COPD exacerbation: an assessment using fluid dynamic modeling Hajian B, De Backer J, Vos W, van Geffen WH, De Winter P, Usmani O, Cahn A, Kerstjens HAM, Pistolesi M, De Backer W International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:833-842 Published Date: 6 March 2018

ORIGINAL RESEARCH

Depressive status explains a significant amount of the variance in COPD assessment test (CAT) scores Miravitlles M, Molina J, Quintano JA, Campuzano A, Pérez J, Roncero C International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:823-831 Published Date: 6 March 2018

ORIGINAL RESEARCH

Use of a 4-week up-titration regimen of roflumilast in patients with severe COPD Watz H, Bagul N, Rabe KF, Rennard S, Alagappan VKT, Román J, Facius A, Calverley PMA International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:813-822 Published Date: 6 March 2018

ORIGINAL RESEARCH

Distinct pain profiles in patients with chronic obstructive pulmonary disease Bentsen SB, Miaskowski C, Cooper BA, Christensen VL, Henriksen AH, Holm AM, Rustøen T International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:801-811 Published Date: 6 March 2018

ORIGINAL RESEARCH

Metformin use and health care utilization in patients with coexisting chronic obstructive pulmonary disease and diabetes mellitus Bishwakarma R, Zhang W, Lin YL, Kuo YF, Cardenas VJ, Sharma G International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:793-800 Published Date: 5 March 2018

ORIGINAL RESEARCH

Factors influencing treatment escalation from long-acting muscarinic antagonist monotherapy to triple therapy in patients with COPD: a retrospective THIN-database analysis Hurst JR, Dilleen M, Morris K, Hills S, Emir B, Jones R International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:781-792 Published Date: 5 March 2018

ORIGINAL RESEARCH

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages Lea SR, Reynolds SL, Kaur M, Simpson KD, Hall SR, Hessel EM, Singh D International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:771-780 Published Date: 2 March 2018

ORIGINAL RESEARCH

Relationship between the presence of bronchiectasis and acute exacerbation in Thai COPD patients Kawamatawong T, Onnipa J, Suwatanapongched T International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:761-769 Published Date: 2 March 2018

REVIEW

Home noninvasive ventilatory support for patients with chronic obstructive pulmonary disease: patient selection and perspectives Storre JH, Callegari J, Magnet FS, Schwarz SB, Duiverman ML, Wijkstra PJ, Windisch W International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:753-760 Published Date: 28 February 2018

ORIGINAL RESEARCH

The effect of environmental factors on the differential expression of miRNAs in patients with chronic obstructive pulmonary disease: a pilot clinical study Liu PF, Yan P, Zhao DH, Shi WF, Meng S, Liu Y, Liu B, Li GF, Xie LX International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:741-751 Published Date: 28 February 2018

ORIGINAL RESEARCH

Effect of the economic crisis on the use of health and home care services among Spanish COPD patients de Miguel-Diez J, Lopez-de-Andres A, Hernandez-Barrera V, Jimenez-Trujillo I, Puente-Maestu L, Cerezo-Lajas A, Jimenez-Garcia R International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:725-739 Published Date: 28 February 2018

ORIGINAL RESEARCH

The relationship between exercise capacity and different functional markers in pulmonary rehabilitation for COPD Kerti M, Balogh Z, Kelemen K, Varga JT International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:717-724 Published Date: 28 February 2018

ORIGINAL RESEARCH

Reduced MBD2 expression enhances airway inflammation in bronchial epithelium in COPD Zeng ZL, Li M, Chen JK, Li QH, Ning Q, Zhao JP, Xu YJ, Xie JG, Yu J International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:703-715 Published Date: 28 February 2018

ORIGINAL RESEARCH

Factors associated with appropriate inhaler use in patients with COPD – lessons from the REAL survey Price D, Keininger DL, Viswanad B, Gasser M, Walda S, Gutzwiller FS International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:695-702 Published Date: 26 February 2018

REVIEW

Early life insults as determinants of chronic obstructive pulmonary disease in adult life Savran O, Ulrik CS International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:683-693 Published Date: 26 February 2018

ORIGINAL RESEARCH

Co-existence of COPD and bronchiectasis: a risk factor for a high ratio of main pulmonary artery to aorta diameter (PA:A) from computed tomography in COPD patients Dou S, Zheng C, Ji X, Wang W, Xie M, Cui L, Xiao W International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:675-681 Published Date: 26 February 2018

ORIGINAL RESEARCH

Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from the 2005–2008 National Health and Nutrition Examination Survey Du W, Liu J, Zhou J, Ye D, OuYang Y, Deng Q International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:665-674 Published Date: 27 February 2018

ORIGINAL RESEARCH

Real-life evaluation of COPD treatment in a Bulgarian population: a 1-year prospective, observational, noninterventional study Ivanov Y, Nikolaev I, Nemeth I International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:653-663 Published Date: 22 February 2018

ORIGINAL RESEARCH

The outcome and the influencing factors of the age of onset in post-mortem of chronic bronchitis patients: a retrospective study Zhu L, Ni Z, Luo X, Zhang Z, Wang S, Meng Z, Gu X, Wang X International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:645-652 Published Date: 21 February 2018

ORIGINAL RESEARCH

Relationship of annual change in bone mineral density with extent of emphysematous lesions and pulmonary function in patients with COPD Goto K, Ogawa E, Shimizu K, Makita H, Suzuki H, Kawata Y, Niki N, Nishimura M, Nakano Y International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:639-644 Published Date: 20 February 2018

ORIGINAL RESEARCH

TNF promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning Reséndiz-Hernández JM, Ambrocio-Ortiz E, Pérez-Rubio G, López-Flores LA, Abarca-Rojano E, Pavón-Romero GF, Flores-Trujillo F, Hernández-Zenteno RJ, Camarena A, Pérez-Rodríguez M, Salazar AM, Ramírez-Venegas A, Falfán-Valencia R International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:627-637 Published Date: 16 February 2018

ORIGINAL RESEARCH

Safety and effectiveness of the high-frequency chest wall oscillation vs intrapulmonary percussive ventilation in patients with severe COPD Nicolini A, Grecchi B, Ferrari-Bravo M, Barlascini C International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:617-625 Published Date: 16 February 2018

ORIGINAL RESEARCH

Seasonal variations in exacerbations and deaths in patients with COPD during the TIOSPIR® trial Wise RA, Calverley PMA, Carter K, Clerisme-Beaty E, Metzdorf N, Anzueto A International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:605-616 Published Date: 14 February 2018

CORRIGENDUM

Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD [Corrigendum] Ma R, Gong XF, Jiang H, Lin CY, Chen YQ, Xu XM, Zhang CT, Wang J, Lu WJ, Zhong NS International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:603-604 Published Date: 13 February 2018

ORIGINAL RESEARCH

Mixed Th2 and non-Th2 inflammatory pattern in the asthma–COPD overlap: a network approach Pérez de Llano L, Cosío BG, Iglesias A, de las Cuevas N, Soler-Cataluña JJ, Izquierdo JL, López-Campos JL, Calero C, Plaza V, Miravitlles M, Torrego A, Martinez Moragon E, Soriano JB, Lopez Viña A, Bobolea I International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:591-601 Published Date: 12 February 2018

ORIGINAL RESEARCH

Burden of COPD in Nepal Adhikari TB, Neupane D, Kallestrup P International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:583-589 Published Date: 9 February 2018

ORIGINAL RESEARCH

Endoplasmic reticulum chaperone GRP78 mediates cigarette smoke-induced necroptosis and injury in bronchial epithelium Wang Y, Zhou JS, Xu XC, Li ZY, Chen HP, Ying SM, Li W, Shen HH, Chen ZH International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:571-581 Published Date: 9 February 2018

CLINICAL TRIAL REPORT

New bacterial growth in bronchial secretions after bronchoscopic valve implantation Sarmand N, Gompelmann D, Kontogianni K, Polke M, Herth FJF, Eberhardt R International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:565-570 Published Date: 8 February 2018

ORIGINAL RESEARCH

CT densitometry in emphysema: a systematic review of its clinical utility Crossley D, Renton M, Khan M, Low EV, Turner AM International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:547-563 Published Date: 7 February 2018

ORIGINAL RESEARCH

Immune cell response to strenuous resistive breathing: comparison with whole body exercise and the effects of antioxidants Asimakos A, Toumpanakis D, Karatza MH, Vasileiou S, Katsaounou P, Mastora Z, Vassilakopoulos T International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:529-545 Published Date: 7 February 2018

ORIGINAL RESEARCH

Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease Hu XW, Wang HB, Tu YH, Fei MD, Yin MM, Fei GH, Yu YQ International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:519-528 Published Date: 7 February 2018

ORIGINAL RESEARCH

Incidence and risk of chronic obstructive pulmonary disease in a Korean community-based cohort Leem AY, Park B, Kim YS, Jung JY, Won S International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:509-517 Published Date: 5 February 2018

ORIGINAL RESEARCH

Long-term health-related quality-of-life and symptom response profiles with arformoterol in COPD: results from a 52-week trial Donohue JF, Bollu VK, Stull DE, Nelson LM, Williams VSL, Stensland MD, Hanania NA International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:499-508 Published Date: 5 February 2018

ORIGINAL RESEARCH

Missed diagnosis and overtreatment of COPD among smoking primary care population in Central Greece: old problems persist Stafyla E, Kotsiou OS, Deskata K, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:487-498 Published Date: 5 February 2018

ORIGINAL RESEARCH

Annexin A1 is elevated in patients with COPD and affects lung fibroblast function Lai TW, Li YY, Mai ZJ, Wen XX, Lv YY, Xie ZQ, Lv QC, Chen M, Wu D, Wu B International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:473-486 Published Date: 5 February 2018

ORIGINAL RESEARCH

The minimal important difference for target lobe volume reduction after endoscopic valve therapy Gompelmann D, Kontogianni K, Schuhmann M, Eberhardt R, Heussel CP, Herth FJ International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:465-472 Published Date: 1 February 2018

ORIGINAL RESEARCH

Do not do in COPD: consensus statement on overuse Villar-Álvarez F, Moreno-Zabaleta R, Mira-Solves JJ, Calvo-Corbella E, Díaz-Lobato S, González-Torralba F, Hernando-Sanz A, Núñez-Palomo S, Salgado-Aranda S, Simón-Rodríguez B, Vaquero-Lozano P, Navarro-Soler IM International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:451-463 Published Date: 2 February 2018

ORIGINAL RESEARCH

Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease Hutchinson D, Müller J, McCarthy JE, Gun'ko YK, Verma NK, Bi X, Di Cristo L, Kickham L, Movia D, Prina-Mello A, Volkov Y International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:441-449 Published Date: 31 January 2018

ORIGINAL RESEARCH

The distribution of blood eosinophil levels in a Japanese COPD clinical trial database and in the rest of the world Barnes N, Ishii T, Hizawa N, Midwinter D, James M, Hilton E, Jones PW International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:433-440 Published Date: 2 February 2018

REVIEW

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications Chapman KR, Chorostowska-Wynimko J, Koczulla AR, Ferrarotti I, McElvaney NG International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:419-432 Published Date: 31 January 2018

ORIGINAL RESEARCH

The YKL-40 protein is a potential biomarker for COPD: a meta-analysis and systematic review Tong X, Wang D, Liu S, Ma Y, Li Z, Tian P, Fan H International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:409-418 Published Date: 30 January 2018

EXPERT OPINION

Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition) Shen Y, Huang S, Kang J, Lin J, Lai K, Sun Y, Xiao W, Yang L, Yao W, Cai S, Huang K, Wen F International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:399-407 Published Date: 30 January 2018

ORIGINAL RESEARCH

Sex-specific cardiopulmonary exercise testing indices to estimate the severity of inoperable chronic thromboembolic pulmonary hypertension Chen TX, Pudasaini B, Guo J, Gong SG, Jiang R, Wang L, Zhao QH, Wu WH, Yuan P, Liu JM International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:385-397 Published Date: 26 January 2018

ORIGINAL RESEARCH

Emphysema and bronchiectasis in COPD patients with previous pulmonary tuberculosis: computed tomography features and clinical implications Jin J, Li S, Yu W, Liu XF, Sun Y International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:375-384 Published Date: 24 January 2018

ORIGINAL RESEARCH

Symptom burden and self-management in persons with chronic obstructive pulmonary disease Bringsvor HB, Skaug K, Langeland E, Oftedal BF, Assmus J, Gundersen D, Osborne RH, Bentsen SB International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:365-373 Published Date: 24 January 2018

ORIGINAL RESEARCH

The clinical implication of serum cyclophilin A in patients with chronic obstructive pulmonary disease Zhang M, Tang J, Yin J, Wang X, Feng X, Yang X, Shan H, Zhang Q, Zhang J, Li Y International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:357-363 Published Date: 19 January 2018

ORIGINAL RESEARCH

Impact of using the new GOLD classification on the distribution of COPD severity in clinical practice Hernández M, García G, Falco J, García AR, Martín V, Ibarrola M, Quadrelli S International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:351-356 Published Date: 17 January 2018

REVIEW

Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease Tashkin DP, Wechsler ME International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:335-349 Published Date: 17 January 2018

COMMENTARY

Low back pain and gastroesophageal reflux in patients with COPD: the disease in the breath Bordoni B, Marelli F, Morabito B, Sacconi B, Caiazzo P, Castagna R International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:325-334 Published Date: 17 January 2018

ORIGINAL RESEARCH

Risk of empyema in patients with COPD Lu HY, Liao KM International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:317-324 Published Date: 15 January 2018

ORIGINAL RESEARCH

The annual direct costs of stable COPD in Greece Stafyla E, Geitona M, Kerenidi T, Economou A, Daniil Z, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:309-315 Published Date: 15 January 2018

ORIGINAL RESEARCH

Epidemiological study of PM2.5 and risk of COPD-related hospital visits in association with particle constituents in Chuncheon, Korea Jo YS, Lim MN, Han YJ, Kim WJ International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:299-307 Published Date: 12 January 2018

ORIGINAL RESEARCH

Narrative medicine to improve the management and quality of life of patients with COPD: the first experience applying parallel chart in Italy Banfi P, Cappuccio A, Latella ME, Reale L, Muscianisi E, Marini MG International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:287-297 Published Date: 11 January 2018

ORIGINAL RESEARCH

Economic burden of COPD in a Swedish cohort: the ARCTIC study Lisspers K, Larsson K, Johansson G, Janson C, Costa-Scharplatz M, Gruenberger JB, Uhde M, Jorgensen L, Gutzwiller FS, Ställberg B International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:275-285 Published Date: 11 January 2018

ORIGINAL RESEARCH

Efficacy of supervised maintenance exercise following pulmonary rehabilitation on health care use: a systematic review and meta-analysis Jenkins AR, Gowler H, Curtis F, Holden NS, Bridle C, Jones AW International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:257-273 Published Date: 10 January 2018

ORIGINAL RESEARCH

Independent determinants of disease-related quality of life in COPD – scope for nonpharmacologic interventions? Brien SB, Stuart B, Dickens AP, Kendrick T, Jordan RE, Adab P, Thomas M International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:247-256 Published Date: 9 January 2018

ORIGINAL RESEARCH

Antibiotic-resistant Pseudomonas aeruginosa infection in patients with bronchiectasis: prevalence, risk factors and prognostic implications Gao YH, Guan WJ, Zhu YN, Chen RC, Zhang GJ International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:237-246 Published Date: 9 January 2018

REVIEW

Which patients with moderate hypoxemia benefit from long-term oxygen therapy? Ways forward Ekström M, Ringbaek T International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:231-235 Published Date: 9 January 2018

ORIGINAL RESEARCH

Phenotyping COPD exacerbations using imaging and blood-based biomarkers Alotaibi NM, Chen V, Hollander Z, Hague CJ, Murphy DT, Leipsic JA, DeMarco ML, FitzGerald JM, McManus BM, Ng RT, Sin DD International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:217-229 Published Date: 8 January 2018

ORIGINAL RESEARCH

Relationship between exercise endurance and static hyperinflation in a post hoc analysis of two clinical trials in patients with COPD Singh S, Maltais F, Tombs L, Fahy WA, Vahdati-Bolouri M, Locantore N, Riley JH International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:203-215 Published Date: 8 January 2018

ORIGINAL RESEARCH

Predictors of pneumonia on routine chest radiographs in patients with COPD: a post hoc analysis of two 1-year randomized controlled trials Rubin DB, Ahmad HA, O'Neal M, Bennett S, Lettis S, Galkin DV, Crim C International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:189-201 Published Date: 8 January 2018

PERSPECTIVES

Russian guidelines for the management of COPD: algorithm of pharmacologic treatment Aisanov Z, Avdeev S, Arkhipov V, Belevskiy A, Chuchalin A, Leshchenko I, Ovcharenko S, Shmelev E, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:183-187 Published Date: 8 January 2018

ORIGINAL RESEARCH

Religious coping and religiosity in patients with COPD following pulmonary rehabilitation da Silva GP, Nascimento FA, Macêdo TP, Morano MT, Mesquita R, Pereira ED International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:175-181 Published Date: 4 January 2018

ORIGINAL RESEARCH

2017 Global Initiative for Chronic Obstructive Lung Disease reclassifies half of COPD subjects to lower risk group Högman M, Sulku J, Ställberg B, Janson C, Bröms K, Hedenström H, Lisspers K, Malinovschi A International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:165-173 Published Date: 3 January 2018

ORIGINAL RESEARCH

Airway reactivity to mannitol is similarly increased in chronic cigarette and water pipe smokers Scherr A, Schmidlin J, Albisser S, Tamm M, Stolz D International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:157-163 Published Date: 3 January 2018

ORIGINAL RESEARCH

Exposure to environmental tobacco smoke from husband more strongly impacts on the airway obstruction of nonsmoking women Suyama K, Kozu R, Tanaka T, Ishimatsu Y, Sawai T International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:149-155 Published Date: 28 December 2017

ORIGINAL RESEARCH

Impact of acute exacerbations on platelet reactivity in chronic obstructive pulmonary disease patients Muñoz-Esquerre M, Ferreiro JL, Huertas D, Marcano AL, López-Sánchez M, Roura G, Gómez-Hospital JA, Dorca J, Cequier A, Santos S International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:141-148 Published Date: 28 December 2017

ORIGINAL RESEARCH

Understanding of COPD among final-year medical students Mohigefer J, Calero-Acuña C, Marquez-Martin E, Ortega-Ruiz F, Lopez-Campos JL International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:131-139 Published Date: 28 December 2017

ORIGINAL RESEARCH

Risk factors predict frequent hospitalization in patients with acute exacerbation of COPD Wei X, Ma ZQ, Yu N, Ren JT, Jin CW, Mi JY, Shi MJ, Tian LB, Gao YZ, Guo YM International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:121-129 Published Date: 27 December 2017

ORIGINAL RESEARCH

Examining 30-day COPD readmissions through the emergency department Rezaee ME, Ward CE, Nuanez B, Rezaee DA, Ditkoff J, Halalau A International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:109-120 Published Date: 27 December 2017

ORIGINAL RESEARCH

Comparison of COPD Assessment Test and Clinical COPD Questionnaire to predict the risk of exacerbation Jo YS, Yoon HI, Kim DK, Yoo CG, Lee CH International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:101-107 Published Date: 22 December 2017

ORIGINAL RESEARCH

Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD Skjørten I, Hilde JM, Melsom MN, Hisdal J, Hansteen V, Steine K, Humerfelt S International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:91-100 Published Date: 22 December 2017

ORIGINAL RESEARCH

Association between respiratory impedance measured by forced oscillation technique and exacerbations in patients with COPD Yamagami H, Tanaka A, Kishino Y, Mikuni H, Kawahara T, Ohta S, Yamamoto M, Suzuki S, Ohnishi T, Sagara H International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:79-89 Published Date: 22 December 2017

ORIGINAL RESEARCH

The impact of indacaterol/glycopyrronium fixed-dose combination versus tiotropium monotherapy on lung function and treatment preference: a randomized crossover study – the FAVOR study Kardos P, Hagedorn-Peinz I International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:69-77 Published Date: 22 December 2017

ORIGINAL RESEARCH

Geographical distribution of COPD prevalence in Europe, estimated by an inverse distance weighting interpolation technique Blanco I, Diego I, Bueno P, Fernández E, Casas-Maldonado F, Esquinas C, Soriano JB, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:57-67 Published Date: 21 December 2017

REVIEW

Inhaled therapies in patients with moderate COPD in clinical practice: current thinking Ariel A, Altraja A, Belevskiy A, Boros PW, Danila E, Fležar M, Koblizek V, Fridlender ZG, Kostov K, Krams A, Milenkovic B, Somfay A, Tkacova R, Tudoric N, Ulmeanu R, Valipour A International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:45-56 Published Date: 21 December 2017

ORIGINAL RESEARCH

Survival following pulmonary rehabilitation in patients with COPD: the effect of program completion and change in incremental shuttle walking test distance Houchen-Wolloff L, Williams JEA, Green RH, Woltmann G, Steiner MC, Sewell L, Morgan MD, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:37-44 Published Date: 20 December 2017

ORIGINAL RESEARCH

Microbiological airway colonization in COPD patients with severe emphysema undergoing endoscopic lung volume reduction Trudzinski FC, Seiler F, Wilkens H, Metz C, Kamp A, Bals R, Gärtner B, Lepper PM, Becker SL International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:29-35 Published Date: 19 December 2017

ORIGINAL RESEARCH

Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD De Smet EG, Seys LJM, Verhamme FM, Vanaudenaerde BM, Brusselle GG, Bingle CD, Bracke KR International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:11-27 Published Date: 19 December 2017

ORIGINAL RESEARCH

Anxiety and depression among dairy farmers: the impact of COPD Guillien A, Laurent L, Soumagne T, Puyraveau M, Laplante JJ, Andujar P, Annesi-Maesano I, Roche N, Degano B, Dalphin JC International Journal of Chronic Obstructive Pulmonary Disease 2018, 13:1-9 Published Date: 19 December 2017

ORIGINAL RESEARCH

Improved spirometric detection of small airway narrowing: concavity in the expiratory flow– volume curve in people aged over 40 years Johns DP, Das A, Toelle BG, Abramson MJ, Marks GB, Wood-Baker R, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3567-3577 Published Date: 13 December 2017

ORIGINAL RESEARCH

Predicting treatable traits for long-acting bronchodilators in patients with stable COPD Kang J, Kim KT, Lee JH, Kim EK, Kim TH, Yoo KH, Lee JS, Kim WJ, Kim JH, Oh YM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3557-3565 Published Date: 12 December 2017

ORIGINAL RESEARCH

Real-life feasibility and effectiveness of home-based pulmonary rehabilitation in chronic obstructive pulmonary disease requiring medical equipment Coquart JB, Le Rouzic O, Racil G, Wallaert B, Grosbois JM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3549-3556 Published Date: 12 December 2017

ORIGINAL RESEARCH

Impact of mild to moderate COPD on feasibility and prognosis in non-small cell lung cancer patients who received chemotherapy Omote N, Hashimoto N, Morise M, Sakamoto K, Miyazaki S, Ando A, Nakahara Y, Hasegawa Y International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3541-3547 Published Date: 11 December 2017

ORIGINAL RESEARCH

A pre–post intervention study of pulmonary rehabilitation for adults with post-tuberculosis lung disease in Uganda Jones R, Kirenga BJ, Katagira W, Singh SJ, Pooler J, Okwera A, Kasiita R, Enki DG, Creanor S, Barton A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3533-3539 Published Date: 11 December 2017

ORIGINAL RESEARCH

Smoking history and emphysema in asthma–COPD overlap Kurashima K, Takaku Y, Ohta C, Takayanagi N, Yanagisawa T, Kanauchi T, Takahashi O International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3523-3532 Published Date: 7 December 2017

ORIGINAL RESEARCH

Metabolic changes of different high-resolution computed tomography phenotypes of COPD after budesonide–formoterol treatment Wang C, Li JX, Tang D, Zhang JQ, Fang LZ, Fu WP, Liu L, Dai LM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3511-3521 Published Date: 6 December 2017

ORIGINAL RESEARCH

Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD Roscioli E, Jersmann HPA, Lester S, Badiei A, Fon A, Zalewski P, Hodge S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3503-3510 Published Date: 5 December 2017

ORIGINAL RESEARCH

Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients Zeng M, Chen QG, Liang WJ, He WM, Zheng HC, Huang CR International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3495-3501 Published Date: 5 December 2017

REVIEW

Doxofylline is not just another theophylline! Matera MG, Page C, Cazzola M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3487-3493 Published Date: 5 December 2017

ORIGINAL RESEARCH

The impact of dual bronchodilation on cardiovascular serious adverse events and mortality in COPD: a quantitative synthesis Rogliani P, Matera MG, Ora J, Cazzola M, Calzetta L International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3469-3485 Published Date: 5 December 2017

REVIEW

Pneumococcal vaccination and chronic respiratory diseases Froes F, Roche N, Blasi F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3457-3468 Published Date: 5 December 2017

ORIGINAL RESEARCH

Risk factors for the discontinuation of roflumilast in patients with chronic obstructive pulmonary disease Kim KH, Kang HS, Kim JS, Yoon HK, Kim SK, Rhee CK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3449-3456 Published Date: 4 December 2017

ORIGINAL RESEARCH

The contribution of symptoms and comorbidities to the economic impact of COPD: an analysis of the German COSYCONET cohort Wacker ME, Kitzing K, Jörres RA, Leidl R, Schulz H, Karrasch S, Karch A, Koch A, Vogelmeier CF, Holle R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3437-3448 Published Date: 4 December 2017

ORIGINAL RESEARCH

Hand grip endurance test relates to clinical state and prognosis in COPD patients better than 6minute walk test distance Kovarik M, Joskova V, Patkova A, Koblizek V, Zadak Z, Hronek M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3429-3435 Published Date: 1 December 2017

LETTER

Fluticasone propionate and increased risk of pneumonia in COPD: is it PAFR-dependent? Sohal SS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3425-3427 Published Date: 4 December 2017

ORIGINAL RESEARCH

Severe COPD cases from Korea, Poland, and USA have substantial differences in respiratory symptoms and other respiratory illnesses Kim WJ, Yim J, Kim DK, Lee MG, Fuhlbrigge AL, Sliwinski P, Hawrylkiewicz I, Wan ES, Cho MH, Silverman EK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3415-3423 Published Date: 30 November 2017

ORIGINAL RESEARCH

Occupational exposure to vapor, gas, dust, or fumes and chronic airflow limitation, COPD, and emphysema: the Swedish CArdioPulmonary BioImage Study (SCAPIS pilot) Torén K, Vikgren J, Olin A, Rosengren A, Bergström G, Brandberg J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3407-3413 Published Date: 29 November 2017

ORIGINAL RESEARCH

Determinants of exacerbation risk in patients with COPD in the TIOSPIR study Calverley PMA, Tetzlaff K, Dusser D, Wise RA, Mueller A, Metzdorf N, Anzueto A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3391-3405 Published Date: 29 November 2017

ORIGINAL RESEARCH

Gene and miRNA expression profiles in PBMCs from patients with severe and mild emphysema and PiZZ alpha1-antitrypsin deficiency Esquinas C, Janciauskiene S, Gonzalo R, Mas de Xaxars G, Olejnicka B, Belmonte I, Barrecheguren M, Rodríguez E, Nuñez A, Rodríguez-Frías F, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3381-3390 Published Date: 29 November 2017

ORIGINAL RESEARCH

Adherence to a COPD treatment guideline among patients in Hong Kong Chan KP, Ko FW, Chan HS, Wong ML, Mok TY, Choo KL, Hui DSC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3371-3379 Published Date: 28 November 2017

ORIGINAL RESEARCH

Eosinophilic and non-eosinophilic COPD patients with chronic respiratory failure: neutrophil-tolymphocyte ratio as an exacerbation marker Acartürk Tunçay E, Karakurt Z, Aksoy E, Saltürk C, Gungor S, Cıftaslan N, Irmak I, Yavuz D, Ocakli B, Adıgüzel N International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3361-3370 Published Date: 23 November 2017

ORIGINAL RESEARCH

Hemodynamic and gas exchange effects of inhaled iloprost in patients with COPD and pulmonary hypertension Wang L, Jin YZ, Zhao QH, Jiang R, Wu WH, Gong SG, He J, Liu J, Jing ZC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3353-3360 Published Date: 22 November 2017

ORIGINAL RESEARCH

MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells Du C, Lu J, Zhou L, Wu B, Zhou F, Gu L, Xu D, Sun Y International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3341-3351 Published Date: 21 November 2017

ORIGINAL RESEARCH

Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease Bai C, Ichinose M, Lee SH, Lee KH, Jöns O, Bothner U, Zhao Y, Buhl R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3329-3339 Published Date: 20 November 2017

ORIGINAL RESEARCH

Smoking cessation affects the natural history of COPD Bai J, Chen X, Liu S, Yu L, Xu JF International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3323-3328 Published Date: 16 November 2017

ORIGINAL RESEARCH

Healthy lifestyle behaviors among individuals with chronic obstructive pulmonary disease in urban and rural communities in China: a large community-based epidemiological study Yan R, Wang Y, Bo J, Li W International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3311-3321 Published Date: 13 November 2017

ORIGINAL RESEARCH

Different impacts of respiratory symptoms and comorbidities on COPD-specific health-related quality of life by COPD severity Lee H, Jhun BW, Cho J, Yoo KH, Lee JH, Kim DK, Lee JD, Jung KS, Lee JY, Park HY International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3301-3310 Published Date: 13 November 2017

ORIGINAL RESEARCH

The role of pain in pulmonary rehabilitation: a qualitative study Harrison SL, Lee AL, Elliott-Button HL, Shea R, Goldstein RS, Brooks D, Ryan CG, Martin DJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3289-3299 Published Date: 8 November 2017

ORIGINAL RESEARCH

Lung transplantation and survival outcomes in patients with oxygen-dependent COPD with regard to their alpha-1 antitrypsin deficiency status Ekström M, Tanash H International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3281-3287 Published Date: 7 November 2017

ORIGINAL RESEARCH

Correlation and compatibility between surface respiratory electromyography and transesophageal diaphragmatic electromyography measurements during treadmill exercise in stable patients with COPD Wu WL, Guan LL, Li XY, Lin L, Guo BP, Yang YQ, Liang ZY, Wang FY, Zhou LQ, Chen RC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3273-3280 Published Date: 6 November 2017

ORIGINAL RESEARCH

The efficacy of extrafine beclomethasone dipropionate–formoterol fumarate in COPD patients who are not "frequent exacerbators": a post hoc analysis of the FORWARD study Singh D, Vezzoli S, Petruzzelli S, Papi A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3263-3271 Published Date: 3 November 2017

ORIGINAL RESEARCH

Characteristics of COPD patients according to GOLD classification and clinical phenotypes in the Russian Federation: the SUPPORT trial Arkhipov V, Arkhipova D, Miravitlles M, Lazarev A, Stukalina E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3255-3262 Published Date: 3 November 2017

ORIGINAL RESEARCH

The protective effect of PRMT6 overexpression on cigarette smoke extract-induced murine emphysema model He X, Li T, Kang N, Zeng H, Ren S, Zong D, Li J, Cai S, Chen P, Chen Y International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3245-3254 Published Date: 3 November 2017

ORIGINAL RESEARCH

SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients Taka C, Hayashi R, Shimokawa K, Tokui K, Okazawa S, Kambara K, Inomata M, Yamada T, Matsui S, Tobe K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3237-3244 Published Date: 3 November 2017

ORIGINAL RESEARCH

COPD depicted – patients drawing their lungs Kaptein AA, Tiemensma J, Broadbent E, Asijee GM, Voorhaar M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3231-3236 Published Date: 3 November 2017

REVIEW

Overlaps and uncertainties of smoking-related idiopathic interstitial pneumonias Bak SH, Lee HY International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3221-3229 Published Date: 1 November 2017

ORIGINAL RESEARCH

Inflammation and chronic colonization of Haemophilus influenzae in sputum in COPD patients related to the degree of emphysema and bronchiectasis in high-resolution computed tomography Tufvesson E, Markstad H, Bozovic G, Ekberg M, Bjermer L International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3211-3219 Published Date: 1 November 2017

REVIEW

E-cigarettes in patients with COPD: current perspectives Morjaria JB, Mondati E, Polosa R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3203-3210 Published Date: 1 November 2017

CLINICAL TRIAL REPORT

Efficacy of tiotropium and indacaterol monotherapy and their combination on dynamic lung hyperinflation in COPD: a random open-label crossover study Fujimoto K, Yamazaki H, Ura M, Kitaguchi Y International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3195-3201 Published Date: 1 November 2017

ORIGINAL RESEARCH

Prediction models for exacerbations in different COPD patient populations: comparing results of five large data sources Hoogendoorn M, Feenstra TL, Boland M, Briggs AH, Borg S, Jansson SA, Risebrough NA, Slejko JF, Rutten-van Mölken MP International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3183-3194 Published Date: 1 November 2017

ORIGINAL RESEARCH

Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico Leng S, Picchi MA, Tesfaigzi Y, Wu G, Gauderman WJ, Xu F, Gilliland FD, Belinsky SA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3171-3181 Published Date: 30 October 2017

ORIGINAL RESEARCH

A nationwide structure for valid long-term oxygen therapy: 29-year prospective data in Sweden Ekström M, Ahmadi Z, Larsson H, Nilsson T, Wahlberg J, Ström KE, Midgren B International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3159-3169 Published Date: 30 October 2017

ORIGINAL RESEARCH

5-Aza-2'-deoxycytidine protects against emphysema in mice via suppressing p16Ink4a expression in lung tissue He ZH, Chen Y, Chen P, He SD, Zeng HH, Ye JR, Liu D, Cao J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3149-3158 Published Date: 30 October 2017

ORIGINAL RESEARCH

Activation of Notch1 signaling alleviates dysfunction of bone marrow-derived mesenchymal stem cells induced by cigarette smoke extract Cheng Y, Gu W, Zhang G, Li X, Guo XJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3133-3147 Published Date: 27 October 2017

ORIGINAL RESEARCH

Hyperinflated lungs compress the heart during expiration in COPD patients: a new finding on dynamic-ventilation computed tomography Xu Y, Yamashiro T, Moriya H, Tsubakimoto M, Tsuchiya N, Nagatani Y, Matsuoka S, Murayama S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3123-3131 Published Date: 26 October 2017

ORIGINAL RESEARCH

Alveolar –capillary reserve during exercise in patients with chronic obstructive pulmonary disease Behnia M, Wheatley CM, Avolio A, Johnson BD International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3115-3122 Published Date: 24 October 2017

LETTER

Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia Shukla SD, Hansbro PM, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3111-3113 Published Date: 24 October 2017

ORIGINAL RESEARCH

Longitudinal change of COPD assessment test (CAT) in a telehealthcare cohort is associated with exacerbation risk Rassouli F, Baty F, Stolz D, Albrich WC, Tamm M, Widmer S, Brutsche MH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3103-3109 Published Date: 24 October 2017

ORIGINAL RESEARCH

Changes in definition lead to changes in the clinical characteristics across COPD categories according to GOLD 2017: a national cross-sectional survey in China Sun LN, Chen YH, Wu R, Lu M, Yao WZ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3095-3102 Published Date: 20 October 2017

ORIGINAL RESEARCH

Associations between occupational inhalation risks and FeNO levels in airway obstruction patients: results from the National Health and Nutrition Examination Survey, 2007–2012 Huang YC, Yang MC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3085-3093 Published Date: 20 October 2017

ORIGINAL RESEARCH

Computerized screening for cognitive impairment in patients with COPD Campman C, van Ranst D, Meijer JW, Sitskoorn M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3075-3083 Published Date: 19 October 2017

ORIGINAL RESEARCH

Cost-effectiveness of the Aerobika* oscillating positive expiratory pressure device in the management of COPD exacerbations Khoudigian-Sinani S, Kowal S, Suggett JA, Coppolo DP International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3065-3073 Published Date: 19 October 2017

REVIEW

Scientific rationale for the possible inhaled corticosteroid intraclass difference in the risk of pneumonia in COPD Janson C, Stratelis G, Miller-Larsson A, Harrison TW, Larsson K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3055-3064 Published Date: 19 October 2017

ORIGINAL RESEARCH

High prevalence of COPD in atherosclerosis patients Tuleta I, Farrag T, Busse L, Pizarro C, Schaefer C, Pingel S, Nickenig G, Skowasch D, Schahab N International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3047-3053 Published Date: 19 October 2017

ORIGINAL RESEARCH

Beta-blocker under-use in COPD patients Lim KP, Loughrey S, Musk M, Lavender M, Wrobel JP International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3041-3046 Published Date: 17 October 2017

ORIGINAL RESEARCH

Characteristics and potential role of M2 macrophages in COPD He S, Xie L, Lu J, Sun S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3029-3039 Published Date: 17 October 2017

REVIEW

Mesenchymal stromal cell therapy in COPD: from bench to bedside Antunes MA, Lapa e Silva JR, Rocco PRM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3017-3027 Published Date: 16 October 2017

ORIGINAL RESEARCH

Echo intensity of the rectus femoris in stable COPD patients Ye X, Wang MJ, Xiao H International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:3007-3015 Published Date: 13 October 2017

REVIEW

Entropy change of biological dynamics in COPD Jin Y, Chen C, Cao Z, Sun B, Lo IL, Liu T, Zheng J, Sun S, Shi Y, Zhang XD International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2997-3005 Published Date: 12 October 2017

ORIGINAL RESEARCH

Impact of selective and nonselective beta-blockers on the risk of severe exacerbations in patients with COPD Huang YL, Lai CC, Wang YH, Wang CY, Wang JY, Wang HC, Yu CJ, Chen LW International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2987-2996 Published Date: 11 October 2017

ORIGINAL RESEARCH

Efficacy of long-term noninvasive positive pressure ventilation in stable hypercapnic COPD patients with respiratory failure: a meta-analysis of randomized controlled trials Liao H, Pei W, Li H, Luo Y, Wang K, Li R, Xu L, Chen X International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2977-2985 Published Date: 10 October 2017

ORIGINAL RESEARCH

Acute exacerbated COPD: room for improvement in key elements of care Markun S, Franzen DP, Dalla Lana K, Beyer S, Wieser S, Hess T, Kohler M, Rosemann T, Senn O, Steurer-Stey C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2969-2975 Published Date: 10 October 2017

ORIGINAL RESEARCH

A case series of an off-the-shelf online health resource with integrated nurse coaching to support self-management in COPD Early F, Young JS, Robinshaw E, Mi EZ, Mi EZ, Fuld JP International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2955-2967 Published Date: 9 October 2017

ORIGINAL RESEARCH

Positive end-expiratory pressure attenuates hemodynamic effects induced by an overload of inspiratory muscles in patients with COPD Schaper-Magalhães F, Pinho JF, Capuruço CAB, Rodrigues-Machado MG International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2943-2954 Published Date: 6 October 2017

ORIGINAL RESEARCH

Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD Negewo NA, Gibson PG, Wark PAB, Simpson JL, McDonald VM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2929-2942 Published Date: 6 October 2017

REVIEW

Triple therapy in COPD: new evidence with the extrafine fixed combination of beclomethasone dipropionate, formoterol fumarate, and glycopyrronium bromide Singh D, Corradi M, Spinola M, Papi A, Usmani OS, Scuri M, Petruzzelli S, Vestbo J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2917-2928 Published Date: 6 October 2017

ORIGINAL RESEARCH

Effectiveness of treatment with nebulized colistin in patients with COPD Bruguera-Avila N, Marín A, Garcia-Olive I, Radua J, Prat C, Gil M, Ruiz-Manzano J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2909-2915 Published Date: 5 October 2017

REVIEW

Impact and prevention of severe exacerbations of COPD: a review of the evidence Halpin DMG, Miravitlles M, Metzdorf N, Celli B International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2891-2908 Published Date: 5 October 2017

EDITORIAL

Joint statement for the diagnosis, management, and prevention of chronic obstructive pulmonary disease for Gulf Cooperation Council countries and Middle East–North Africa region, 2017 Mahboub BH, Vats MG, Al Zaabi A, Iqbal MN, Safwat T, Al-Hurish F, Miravitlles M, Singh D, Asad K, Zeineldine S, Al-Hajjaj MS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2869-2890 Published Date: 9 October 2017

ORIGINAL RESEARCH

Use of the forced-oscillation technique to estimate spirometry values Yamamoto S, Miyoshi S, Katayama H, Okazaki M, Shigematsu H, Sano Y, Matsubara M, Hamaguchi N, Okura T, Higaki J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2859-2868 Published Date: 3 October 2017

ORIGINAL RESEARCH

Minimal important difference and responsiveness of 2-minute walk test performance in people with COPD undergoing pulmonary rehabilitation Johnston KN, Potter AJ, Phillips AC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2849-2857 Published Date: 9 October 2017

ORIGINAL RESEARCH

Risk of cancer after lung transplantation for COPD Ekström M, Riise GC, Tanash HA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2841-2847 Published Date: 3 October 2017

ORIGINAL RESEARCH

The association between objectively measured physical activity and morning symptoms in COPD van Buul AR, Kasteleyn MJ, Chavannes NH, Taube C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2831-2840 Published Date: 3 October 2017

ORIGINAL RESEARCH

Role of inspiratory capacity on dyspnea evaluation in COPD with or without emphysematous lesions: a pilot study Cui L, Ji X, Xie M, Dou S, Wang W, Xiao W International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2823-2830 Published Date: 30 September 2017

ORIGINAL RESEARCH

Associations between the psychological health of patients and carers in advanced COPD Mi E, Mi E, Ewing G, Mahadeva R, Gardener AC, Holt Butcher H, Booth S, Farquhar M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2813-2821 Published Date: 30 September 2017

ORIGINAL RESEARCH

Specific IgA against Pseudomonas aeruginosa in severe COPD Millares L, Martí S, Ardanuy C, Liñares J, Santos S, Dorca J, García-Nuñez M, Quero S, Monsó E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2807-2811 Published Date: 30 September 2017

ORIGINAL RESEARCH

Proactive palliative care for patients with COPD (PROLONG): a pragmatic cluster controlled trial Duenk RG, Verhagen C, Bronkhorst EM, van Mierlo PJWB, Broeders MEAC, Collard SM, Dekhuijzen PNR, Vissers KCP, Heijdra Y, Engels Y International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2795-2806 Published Date: 28 September 2017

ORIGINAL RESEARCH

Trends in health care resource utilization and pharmacological management of COPD in Taiwan from 2004 to 2010 Tsai YH, Yang TM, Lin CM, Huang SY, Wen YW International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2787-2793 Published Date: 28 September 2017

ORIGINAL RESEARCH

Systemic effects of chronic obstructive pulmonary disease in young-old adults’ life-space mobility Garcia IFF, Tiuganji CT, Simões MSMP, Santoro IL, Lunardi AC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2777-2785 Published Date: 27 September 2017

SHORT REPORT

Comparison of the peripheral blood eosinophil count using near-patient testing and standard automated laboratory measurement in healthy, asthmatic and COPD subjects Hambleton K, Connolly CM, Borg C, Davies JH, Jeffers HP, Russell REK, Bafadhel M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2771-2775 Published Date: 26 September 2017

ORIGINAL RESEARCH

Estimating the effectiveness of pulmonary rehabilitation for COPD exacerbations: reduction of hospital inpatient days during the following year Katajisto M, Laitinen T International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2763-2769 Published Date: 22 September 2017

ORIGINAL RESEARCH

Community pharmacy-based case finding for COPD in urban and rural settings is feasible and effective Fathima M, Saini B, Foster JM, Armour CL International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2753-2761 Published Date: 18 September 2017

ORIGINAL RESEARCH

A pilot clinical trial to determine the safety and efficacy of aerosolized hyaluronan as a treatment for COPD Cantor J, Ma S, Turino G International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2747-2752 Published Date: 18 September 2017

Self-management behaviors to reduce exacerbation impact in COPD patients: a Delphi study Korpershoek YJG, Bruins Slot JC, Effing TW, Schuurmans MJ, Trappenburg JCA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2735-2746 Published Date: 15 September 2017

LETTER

Letter to the editor regarding: "Development of the ProPal-COPD tool to identify patients with COPD for proactive palliative care" Almagro P, Martinez Camblor P International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2731-2734 Published Date: 13 September 2017

ORIGINAL RESEARCH

Impact of overweight and obesity on acute exacerbations of COPD – subgroup analysis of the Taiwan Obstructive Lung Disease cohort Wei YF, Tsai YH, Wang CC, Kuo PH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2723-2729 Published Date: 12 September 2017

ORIGINAL RESEARCH

Comparative study on medical utilization and costs of chronic obstructive pulmonary disease with good lung function Lim JU, Kim K, Kim SH, Lee MG, Lee SY, Yoo KH, Lee SH, Jung KS, Rhee CK, Hwang YI International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2711-2721 Published Date: 11 September 2017

ORIGINAL RESEARCH

Sputum cell count: biomarkers in the differentiation of asthma, COPD and asthma-COPD overlap Gao J, Zhou WT, Chen BD, Lin WM, Wu SF, Wu F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2703-2710 Published Date: 11 September 2017

ORIGINAL RESEARCH

Factors facilitating and hindering the intention to promote pulmonary rehabilitation for patients with COPD among respiratory therapists Chen YJ, Fan JY, Guo SE, Hwang SL, Yang TM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2695-2702 Published Date: 11 September 2017

REVIEW

Acute exacerbations of COPD: risk factors for failure and relapse Mantero M, Rogliani P, Di Pasquale M, Polverino E, Crisafulli E, Guerrero M, Gramegna A, Cazzola M, Blasi F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2687-2693 Published Date: 8 September 2017

ORIGINAL RESEARCH

The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream Hakamy A, McKeever TM, Steiner MC, Roberts CM, Singh SJ, Bolton CE International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2681-2686 Published Date: 8 September 2017

LETTER

Essential need for rethink of COPD airway pathology: implications for new drug approaches for prevention of lung cancer as well as small airway fibrosis Sohal SS, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2677-2679 Published Date: 7 September 2017

ORIGINAL RESEARCH

Usefulness of the desaturation–distance ratio from the six-minute walk test for patients with COPD Fujimoto Y, Oki Y, Kaneko M, Sakai H, Misu S, Yamaguchi T, Mitani Y, Yasuda H, Ishikawa A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2669-2675 Published Date: 6 September 2017

ORIGINAL RESEARCH

Cycle ergometer and inspiratory muscle training offer modest benefit compared with cycle ergometer alone: a comprehensive assessment in stable COPD patients Wang K, Zeng G, Li R, Luo Y, Wang M, Hu Y, Xu W, Zhou L, Chen R, Chen X International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2655-2668 Published Date: 6 September 2017

ORIGINAL RESEARCH

Capillary PO2 does not adequately reflect arterial PO2 in hypoxemic COPD patients Magnet FS, Majorski DS, Callegari J, Schwarz SB, Schmoor C, Windisch W, Storre JH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2647-2653 Published Date: 6 September 2017

ORIGINAL RESEARCH

Differences in systemic inflammation between cigarette and biomass smoke-induced COPD Golpe R, Martín-Robles I, Sanjuán-López P, Pérez-de-Llano L, González-Juanatey C, López-Campos JL, ArellanoOrden E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2639-2646 Published Date: 1 September 2017

ORIGINAL RESEARCH

Sensitization to Aspergillus fumigatus as a risk factor for bronchiectasis in COPD Everaerts S, Lagrou K, Dubbeldam A, Lorent N, Vermeersch K, Van Hoeyveld E, Bossuyt X, Dupont LJ, Vanaudenaerde BM, Janssens W International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2629-2638 Published Date: 31 August 2017

ORIGINAL RESEARCH

A new functional method to choose the target lobe for lung volume reduction in emphysema – comparison with the conventional densitometric method Hetzel J, Boeckeler M, Horger M, Ehab A, Kloth C, Wagner R, Freitag L, Slebos DJ, Lewis RA, Haentschel M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2621-2628 Published Date: 30 August 2017

ORIGINAL RESEARCH

Psychometric properties of the Korean version of the Pulmonary Rehabilitation Adapted Index of Self-Efficacy (PRAISE) for individuals with COPD Song HY, Nam KA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2611-2620 Published Date: 29 August 2017

REVIEW

Chronic obstructive pulmonary disease with mild airflow limitation: current knowledge and proposal for future research – a consensus document from six scientific societies Rossi A, Butorac-Petanjek B, Chilosi M, Cosío BG, Flezar M, Koulouris N, Marin J, Miculinic N, Polese G, Samaržija M, Skrgat S, Vassilakopoulos T, Vukić-Dugac A, Zakynthinos S, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2593-2610 Published Date: 29 August 2017

CLINICAL TRIAL REPORT

Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial Rafiq R, Prins HJ, Boersma WG, Daniels JMA, den Heijer M, Lips P, de Jongh RT International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2583-2592 Published Date: 28 August 2017

ORIGINAL RESEARCH

The evaluation of -adrenoceptor blocking agents in patients with COPD and congestive heart failure: a nationwide study Liao KM, Lin T, Huang Y, Kuo C, Chen C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2573-2581 Published Date: 26 August 2017

ORIGINAL RESEARCH

Comparison of pulsed versus continuous oxygen delivery using realistic adult nasal airway replicas Chen JZ, Katz IM, Pichelin M, Zhu K, Caillibotte G, Noga ML, Finlay WH, Martin AR International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2559-2571 Published Date: 24 August 2017

ORIGINAL RESEARCH

ACTIVATE: the effect of aclidinium/formoterol on hyperinflation, exercise capacity, and physical activity in patients with COPD Watz H, Troosters T, Beeh KM, Garcia-Aymerich J, Paggiaro P, Molins E, Notari M, Zapata A, Jarreta D, Garcia Gil E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2545-2558 Published Date: 24 August 2017

ORIGINAL RESEARCH

Determinants of each domain of the Short Physical Performance Battery in COPD Bernabeu-Mora R, Giménez-Giménez LM, Montilla-Herrador J, García-Guillamón G, García-Vidal JA, MedinaMirapeix F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2539-2544 Published Date: 23 August 2017

ORIGINAL RESEARCH

Effect of a rehabilitation-based chronic disease management program targeting severe COPD exacerbations on readmission patterns Lalmolda C, Coll-Fernández R, Martínez N, Baré M, Teixidó Colet M, Epelde F, Monso E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2531-2538 Published Date: 23 August 2017

ORIGINAL RESEARCH

Incidence and risk factors of atrial fibrillation in Asian COPD patients Liao KM, Chen CY International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2523-2530 Published Date: 23 August 2017

ORIGINAL RESEARCH

Contributions of COPD, asthma, and ten comorbid conditions to health care utilization and patient-centered outcomes among US adults with obstructive airway disease Murphy TE, McAvay GJ, Allore HG, Stamm JA, Simonelli PF International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2515-2522 Published Date: 23 August 2017

ORIGINAL RESEARCH

Ischemic ECG abnormalities are associated with an increased risk for death among subjects with COPD, also among those without known heart disease Nilsson U, Blomberg A, Johansson B, Backman H, Eriksson B, Lindberg A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2507-2514 Published Date: 22 August 2017

REVIEW

Systematic review of the association between exercise tests and patient-reported outcomes in patients with chronic obstructive pulmonary disease Punekar YS, Riley JH, Lloyd E, Driessen M, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2487-2506 Published Date: 22 August 2017

ORIGINAL RESEARCH

Severe exacerbation and pneumonia in COPD patients treated with fixed combinations of inhaled corticosteroid and long-acting beta2 agonist Yang HH, Lai CC, Wang YH, Yang WC, Wang CY, Wang HC, Chen L, Yu CJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2477-2485 Published Date: 21 August 2017

ORIGINAL RESEARCH

Comparison of World Health Organization and Asia-Pacific body mass index classifications in COPD patients Lim JU, Lee JH, Kim JS, Hwang YI, Kim T, Lim SY, Yoo KH, Jung KS, Kim YK, Rhee CK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2465-2475 Published Date: 21 August 2017

ORIGINAL RESEARCH

Clinical implications of blood eosinophil count in patients with non-asthma–COPD overlap syndrome COPD Song JH, Lee C, Kim JW, Lee WY, Jung JY, Park JH, Jung KS, Yoo KH, Park YB, Kim DK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2455-2464 Published Date: 17 August 2017

ORIGINAL RESEARCH

The comparative effectiveness of initiating fluticasone/salmeterol combination therapy via pMDI versus DPI in reducing exacerbations and treatment escalation in COPD: a UK database study Jones R, Martin J, Thomas V, Skinner D, Marshall J, Stagno d'Alcontres M, Price D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2445-2454 Published Date: 17 August 2017

ORIGINAL RESEARCH

Risk factors for pulmonary arterial hypertension in patients with tuberculosis-destroyed lungs and their clinical characteristics compared with patients with chronic obstructive pulmonary disease Jo YS, Park JH, Lee JK, Heo EY, Chung HS, Kim DK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2433-2443 Published Date: 16 August 2017

ORIGINAL RESEARCH

Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom Braeken DCW, Rohde GGU, Franssen FME, Driessen JHM, van Staa TP, Souverein PC, Wouters EFM, de Vries F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2425-2432 Published Date: 14 August 2017

ORIGINAL RESEARCH

Overdiagnosis of COPD in hospitalized patients Spero K, Bayasi G, Beaudry L, Barber KR, Khorfan F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2417-2423 Published Date: 11 August 2017

ORIGINAL RESEARCH

Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease Majewski S, Pietrzak A, Tworek D, Szewczyk K, Kumor-Kisielewska A, Kurmanowska Z, Górski P, ZalewskaJanowska A, Piotrowski WJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2407-2415 Published Date: 11 August 2017

ORIGINAL RESEARCH

Network meta-analysis of success rate and safety in antibiotic treatments of bronchitis Wang J, Xu H, Liu P, Li M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2391-2405 Published Date: 9 August 2017

ORIGINAL RESEARCH

Hand grip strength in patients with chronic obstructive pulmonary disease Jeong M, Kang HK, Song P, Park HK, Jung H, Lee SS, Koo HK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2385-2390 Published Date: 9 August 2017

ORIGINAL RESEARCH

Identification and distribution of COPD phenotypes in clinical practice according to Spanish COPD Guidelines: the FENEPOC study Calle Rubio M, Casamor R, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2373-2383 Published Date: 9 August 2017

ORIGINAL RESEARCH

A comprehensive analysis of association of medical history with airflow limitation: a crosssectional study Nishida Y, Takahashi Y, Tezuka K, Yamazaki K, Yada Y, Nakayama T, Asai S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2363-2371 Published Date: 8 August 2017

ORIGINAL RESEARCH

Presence of sarcopenia in asthma–COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES) IV and V (2008–2011) Lee DW, Jin HJ, Shin KC, Chung JH, Lee HW, Lee KH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2355-2362 Published Date: 7 August 2017

REVIEW

Small airways disease: time for a revisit? Stockley JA, Cooper BG, Stockley RA, Sapey E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2343-2353 Published Date: 7 August 2017

CLINICAL TRIAL REPORT

An evaluation of activity tolerance, patient-reported outcomes and satisfaction with the effectiveness of pulmonary daoyin on patients with chronic obstructive pulmonary disease Zhang H, Li J, Yu X, Li S, Halmurat U, Xie Y, Wang YF, Li F, Wang M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2333-2342 Published Date: 4 August 2017

ORIGINAL RESEARCH

Multicenter study of the COPD-6 screening device: feasible for early detection of chronic obstructive pulmonary disease in primary care? Kjeldgaard P, Lykkegaard J, Spillemose H, Ulrik CS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2323-2331 Published Date: 4 August 2017

ORIGINAL RESEARCH

Hand grip strength and chronic obstructive pulmonary disease in Korea: an analysis in KNHANES VI Lee SH, Kim SJ, Han Y, Ryu YJ, Lee JH, Chang JH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2313-2321 Published Date: 4 August 2017

REVIEW

Spotlight on glycopyrronium/formoterol fumarate inhalation aerosol in the management of COPD: design, development, and place in therapy Dhungana S, Criner GJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2307-2312 Published Date: 3 August 2017

REVIEW

When is dual bronchodilation indicated in COPD? Thomas M, Halpin DMG, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2291-2305 Published Date: 3 August 2017

ORIGINAL RESEARCH

Prognostic role of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio for hospital mortality in patients with AECOPD Yao CY, Liu XL, Tang Z International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2285-2290 Published Date: 3 August 2017

ORIGINAL RESEARCH

Effect of carbocisteine on patients with COPD: a systematic review and meta-analysis Zeng Z, Yang D, Huang X, Xiao ZL International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2277-2283 Published Date: 2 August 2017

ORIGINAL RESEARCH

Validity of physician-diagnosed COPD in relation to spirometric definitions of COPD in a general population aged 50–64 years – the SCAPIS pilot study Torén K, Murgia N, Olin AC, Hedner J, Brandberg J, Rosengren A, Bergström G International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2269-2275 Published Date: 4 August 2017

ORIGINAL RESEARCH

Platelet distribution width as a prognostic factor in patients with COPD – pilot study Białas AJ, Pedone C, Piotrowski WJ, Antonelli Incalzi R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2261-2267 Published Date: 1 August 2017

RESEARCH LETTER

Improving adherence to alpha-1 antitrypsin deficiency screening guidelines using the pulmonary function laboratory Luna Diaz LV, Iupe I, Zavala B, Balestrini KC, Guerrero A, Holt G, Calderon-Candelario R, Mirsaeidi M, Campos M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2257-2259 Published Date: 31 July 2017

REVIEW

Prognostic variables and scores identifying the end of life in COPD: a systematic review Smith LE, Moore E, Ali I, Smeeth L, Stone P, Quint JK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2239-2256 Published Date: 31 July 2017

ORIGINAL RESEARCH

Effect of allergic phenotype on treatment response to inhaled bronchodilators with or without inhaled corticosteroids in patients with COPD Cheng S, Wang HH, Lin C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2231-2238 Published Date: 31 July 2017

ORIGINAL RESEARCH

Increased parasympathetic cardiac modulation in patients with acute exacerbation of COPD: how should we interpret it? Kabbach EZ, Mazzuco A, Borghi-Silva A, Cabiddu R, Agnoleto AG, Barbosa JF, de Carvalho Junior LCS, Mendes RG International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2221-2230 Published Date: 28 July 2017

ORIGINAL RESEARCH

Tiotropium bromide exerts anti-inflammatory effects during resistive breathing, an experimental model of severe airway obstruction Toumpanakis D, Loverdos K, Tzouda V, Vassilakopoulou V, Litsiou E, Magkou C, Karavana V, Pieper M, Vassilakopoulos T International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2207-2220 Published Date: 28 July 2017

CLINICAL TRIAL REPORT

Pathophysiological mechanism of long-term noninvasive ventilation in stable hypercapnic patients with COPD using functional respiratory imaging Hajian B, De Backer J, Sneyers C, Ferreira F, Barboza KC, Leemans G, Vos W, De Backer W International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2197-2205 Published Date: 28 July 2017

ORIGINAL RESEARCH

Perception of symptoms and quality of life – comparison of patients’ and physicians’ views in the COPD MIRROR study Celli B, Blasi F, Gaga M, Singh D, Vogelmeier C, Pegoraro V, Caputo N, Agusti A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2189-2196 Published Date: 27 July 2017

ORIGINAL RESEARCH

The association of tidal EFL with exercise performance, exacerbations, and death in COPD Aarli BB, Calverley PM, Jensen RL, Dellacà R, Eagan TM, Bakke PS, Hardie JA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2179-2188 Published Date: 26 July 2017

REVIEW

Counseling for health behavior change in people with COPD: systematic review Williams MT, Effing TW, Paquet C, Gibbs CA, Lewthwaite H, Li LSK, Phillips AC, Johnston KN International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2165-2178 Published Date: 26 July 2017

ORIGINAL RESEARCH

Spreading improvements for advanced COPD care through a Canadian Collaborative Rocker GM, Amar C, Laframboise WL, Burns J, Verma JY International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2157-2164 Published Date: 26 July 2017

REVIEW

Emerging pharmaceutical therapies for COPD Lakshmi SP, Reddy AT, Reddy RC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2141-2156 Published Date: 21 July 2017

ORIGINAL RESEARCH

Effects of a self-management education program on self-efficacy in patients with COPD: a mixedmethods sequential explanatory designed study Ng WI, Smith GD International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2129-2139 Published Date: 20 July 2017

ORIGINAL RESEARCH

Development of the ProPal-COPD tool to identify patients with COPD for proactive palliative care Duenk RG, Verhagen C, Bronkhorst EM, Djamin RS, Bosman GJ, Lammers E, Dekhuijzen PNR, Vissers KCP, Engels Y, Heijdra Y International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2121-2128 Published Date: 20 July 2017

ORIGINAL RESEARCH

Bacteriological incidence in pneumonia patients with pulmonary emphysema: a bacterial floral analysis using the 16S ribosomal RNA gene in bronchoalveolar lavage fluid Naito K, Yamasaki K, Yatera K, Akata K, Noguchi S, Kawanami T, Fukuda K, Kido T, Ishimoto H, Mukae H International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2111-2120 Published Date: 20 July 2017

ORIGINAL RESEARCH

Asynchrony in respiratory movements between the pulmonary lobes in patients with COPD: continuous measurement of lung density by 4-dimensional dynamic-ventilation CT Yamashiro T, Moriya H, Matsuoka S, Nagatani Y, Tsubakimoto M, Tsuchiya N, Murayama S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2101-2109 Published Date: 20 July 2017

ORIGINAL RESEARCH

Risk factors for developing hypoxic respiratory failure in COPD Sundh J, Ekström M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2095-2100 Published Date: 20 July 2017

ORIGINAL RESEARCH

Retrospective analysis to describe associations between tumor necrosis factor alpha inhibitors and COPD-related hospitalizations Accortt NA, Chung JB, Bonafede M, Limone BL, Mannino DM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2085-2094 Published Date: 19 July 2017

ORIGINAL RESEARCH

Indices of iron homeostasis correlate with airway obstruction in an NHANES III cohort Ghio AJ, Hilborn ED International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2075-2084 Published Date: 18 July 2017

ORIGINAL RESEARCH

Clinical characteristics of chronic bronchitic, emphysematous and ACOS phenotypes in COPD patients with frequent exacerbations Cheng YS, Tu XW, Pan LL, Lu S, Xing M, Li LL, Chen XW International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2069-2074 Published Date: 18 July 2017

ORIGINAL RESEARCH

COPD patients’ self-reported adherence, psychosocial factors and mild cognitive impairment in pulmonary rehabilitation Pierobon A, Sini Bottelli E, Ranzini L, Bruschi C, Maestri R, Bertolotti G, Sommaruga M, Torlaschi V, Callegari S, Giardini A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2059-2067 Published Date: 18 July 2017

ORIGINAL RESEARCH

Size variation and collapse of emphysema holes at inspiration and expiration CT scan: evaluation with modified length scale method and image co-registration Oh SY, Lee M, Seo JB, Kim N, Lee SM, Lee JS, Oh YM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2043-2057 Published Date: 13 July 2017

ORIGINAL RESEARCH

Voluntary lung function screening to reveal new COPD cases in southern Italy Capozzolo A, Castellana G, Dragonieri S, Carratù P, Liotino V, Vulpi MR, Marra L, Resta E, Intiglietta P, Resta O International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2035-2042 Published Date: 11 July 2017

ORIGINAL RESEARCH

Alteration of the irisin–brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients Papp C, Pak K, Erdei T, Juhasz B, Seres I, Szentpéteri A, Kardos L, Szilasi M, Gesztelyi R, Zsuga J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2023-2033 Published Date: 7 July 2017

ORIGINAL RESEARCH

Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers Caram LMO, Ferrari R, Nogueira DL, Oliveira MRM, Francisqueti FV, Tanni SE, Corrêa CR, Godoy I International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2015-2021 Published Date: 7 July 2017

CLINICAL TRIAL REPORT

Bronchodilator efficacy of extrafine glycopyrronium bromide: the Glyco 2 study Singh D, Scuri M, Collarini S, Vezzoli S, Mariotti F, Muraro A, Acerbi D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:2001-2014 Published Date: 7 July 2017

ORIGINAL RESEARCH

Active smoking and COPD phenotype: distribution and impact on prognostic factors Riesco JA, Alcázar B, Trigueros JA, Campuzano A, Pérez J, Lorenzo JL International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1989-1999 Published Date: 6 July 2017

ORIGINAL RESEARCH

Mathematical modeling of postcoinfection with influenza A virus and Streptococcus pneumoniae, with implications for pneumonia and COPD-risk assessment Cheng YH, You SH, Lin YJ, Chen SC, Chen WY, Chou WC, Hsieh NH, Liao CM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1973-1988 Published Date: 5 July 2017

ORIGINAL RESEARCH

Fluticasone propionate/formoterol for COPD management: a randomized controlled trial Papi A, Dokic D, Tzimas W, Mészáros I, Olech-Cudzik A, Koroknai Z, McAulay K, Mersmann S, Dalvi PS, Overend T International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1961-1971 Published Date: 5 July 2017

ORIGINAL RESEARCH

Clinical and economic burden of dyspnea and other COPD symptoms in a managed care setting Stephenson JJ, Wertz D, Gu T, Patel J, Dalal AA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1947-1959 Published Date: 4 July 2017

ORIGINAL RESEARCH

Characterization of throat microbial flora in smokers with or without COPD Diao W, Shen N, Du Y, Qian K, He B International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1933-1946 Published Date: 4 July 2017

ORIGINAL RESEARCH

Glycated hemoglobin A1c-based adjusted glycemic variables in patients with diabetes presenting with acute exacerbation of chronic obstructive pulmonary disease Yang CJ, Liao WI, Tang ZC, Wang JC, Lee CH, Chang WC, Hsu CW, Tang SE, Tsai SH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1923-1932 Published Date: 3 July 2017

ORIGINAL RESEARCH

Prevalence and associated factors of COPD among Aboriginal peoples in Canada: a crosssectional study Bird Y, Moraros J, Mahmood R, Esmaeelzadeh S, Kyaw Soe NM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1915-1922 Published Date: 30 June 2017

ORIGINAL RESEARCH

Intracellular interactions of umeclidinium and vilanterol in human airway smooth muscle Shaikh N, Johnson M, Hall DA, Chung KF, Riley JH, Worsley S, Bhavsar PK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1903-1913 Published Date: 30 June 2017

ORIGINAL RESEARCH

Readmission After COPD Exacerbation Scale: determining 30-day readmission risk for COPD patients Lau CSM, Siracuse BL, Chamberlain RS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1891-1902 Published Date: 29 June 2017

ORIGINAL RESEARCH

Interfaces and ventilator settings for long-term noninvasive ventilation in COPD patients Callegari J, Magnet FS, Taubner S, Berger M, Schwarz SB, Windisch W, Storre JH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1883-1889 Published Date: 28 June 2017

REVIEW

Maintenance therapy in COPD: time to phase out ICS and switch to the new LAMA/LABA inhalers? Tariq SM, Thomas EC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1877-1882 Published Date: 23 June 2017

ORIGINAL RESEARCH

Double bronchodilation in chronic obstructive pulmonary disease: a crude analysis from a systematic review Lopez-Campos JL, Calero-Acuña C, Márquez-Martín E, Quintana Gallego E, Carrasco-Hernández L, Abad Arranz M, Ortega Ruiz F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1867-1876 Published Date: 23 June 2017

REVIEW

Th17 profile in COPD exacerbations Ponce-Gallegos MA, Ramírez-Venegas A, Falfán-Valencia R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1857-1865 Published Date: 22 June 2017

ORIGINAL RESEARCH

Anti-p-benzoquinone antibody level as a prospective biomarker to identify smokers at risk for COPD Banerjee S, Bhattacharyya P, Mitra S, Kundu S, Panda S, Chatterjee IB International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1847-1856 Published Date: 21 June 2017

ORIGINAL RESEARCH

Hospital admissions and mortality in patients with COPD exacerbations and vertebral body compression fractures Pascual-Guardia S, Badenes-Bonet D, Martin-Ontiyuelo C, Zuccarino F, Marín-Corral J, Rodríguez A, Barreiro E, Gea J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1837-1845 Published Date: 21 June 2017

ORIGINAL RESEARCH

A retrospective study to assess clinical characteristics and time to initiation of open-triple therapy among patients with chronic obstructive pulmonary disease, newly established on longacting mono- or combination therapy Mapel D, Laliberté F, Roberts MH, Sama SR, Sundaresan D, Pilon D, Lefebvre P, Duh MS, Patel J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1825-1836 Published Date: 21 June 2017

ORIGINAL RESEARCH

Relationship between blood eosinophils, clinical characteristics, and mortality in patients with COPD Zysman M, Deslee G, Caillaud D, Chanez P, Escamilla R, Court-Fortune I, Nesme-Meyer P, Perez T, Paillasseur JL, Pinet C, Jebrak G, Roche N, Burgel PR International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1819-1824 Published Date: 20 June 2017

ORIGINAL RESEARCH

Expression profiling of miRNA-145 and miRNA-338 in serum and sputum of patients with COPD, asthma, and asthma–COPD overlap syndrome phenotype Lacedonia D, Palladino GP, Foschino-Barbaro MP, Scioscia G, Carpagnano GE International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1811-1817 Published Date: 23 June 2017

ORIGINAL RESEARCH

Prevalence and characteristics of asthma–COPD overlap syndrome identified by a stepwise approach Inoue H, Nagase T, Morita S, Yoshida A, Jinnai T, Ichinose M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1803-1810 Published Date: 20 June 2017

ORIGINAL RESEARCH

Health resource utilization for inpatients with COPD treated with nebulized arformoterol or nebulized formoterol Ganapathy V, Stensland MD International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1793-1801 Published Date: 20 June 2017

ORIGINAL RESEARCH

Dysregulation of microRNA-214 and PTEN contributes to the pathogenesis of hypoxic pulmonary hypertension Liu H, Yin T, Yan W, Si R, Wang B, Chen M, Li F, Wang Q, Tao L International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1781-1791 Published Date: 19 June 2017

ORIGINAL RESEARCH

Serum levels of IGFBP7 are elevated during acute exacerbation in COPD patients Ruan W, Wu M, Shi L, Li F, Dong L, Qiu Y, Wu X, Ying K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1775-1780 Published Date: 19 June 2017

ORIGINAL RESEARCH

Dietary beetroot juice – effects on physical performance in COPD patients: a randomized controlled crossover trial Friis AL, Steenholt CB, Løkke A, Hansen M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1765-1773 Published Date: 15 June 2017

ORIGINAL RESEARCH

Treatment trends in patients with asthma–COPD overlap syndrome in a COPD cohort: findings from a real-world survey Ding B, Small M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1753-1763 Published Date: 15 June 2017

ORIGINAL RESEARCH

A novel scoring index by Doppler echocardiography for predicting severe pulmonary hypertension due to chronic lung diseases: a cross-sectional diagnostic accuracy study Jiang R, Wu C, Pudasaini B, Wang L, Zhao QH, Zhang R, Wu WH, Yuan P, Jing ZC, Liu JM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1741-1751 Published Date: 14 June 2017

ORIGINAL RESEARCH

Improvement in 24-hour bronchodilation and symptom control with aclidinium bromide versus tiotropium and placebo in symptomatic patients with COPD: post hoc analysis of a Phase IIIb study Beier J, Mroz R, Kirsten AM, Chuecos F, Garcia Gil E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1731-1740 Published Date: 14 June 2017

ORIGINAL RESEARCH

Palliative care and prognosis in COPD: a systematic review with a validation cohort Almagro P, Yun S, Sangil A, Rodríguez-Carballeira M, Marine M, Landete P, Soler-Cataluña JJ, Soriano JB, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1721-1729 Published Date: 9 June 2017

REVIEW

Features of self-management interventions for people with COPD associated with improved health-related quality of life and reduced emergency department visits: a systematic review and meta-analysis Newham JJ, Presseau J, Heslop-Marshall K, Russell S, Ogunbayo OJ, Netts P, Hanratty B, Kaner E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1705-1720 Published Date: 8 June 2017

ORIGINAL RESEARCH

Pulmonary rehabilitation in COPD – available resources and utilization in Swedish primary and secondary care Sundh J, Lindgren H, Hasselgren M, Montgomery S, Janson C, Ställberg B, Lisspers K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1695-1704 Published Date: 8 June 2017

ORIGINAL RESEARCH

Alpha-1 antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide Blanco I, Bueno P, Diego I, Pérez-Holanda S, Lara B, Casas-Maldonado F, Esquinas C, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1683-1694 Published Date: 8 June 2017

ORIGINAL RESEARCH

Development of a training program to support health care professionals to deliver the SPACE for COPD self-management program Blackmore C, Johnson-Warrington VL, Williams JEA, Apps LD, Young HML, Bourne CLA, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1669-1681 Published Date: 7 June 2017

ORIGINAL RESEARCH

Validity and interpretation of spirometric recordings to diagnose COPD in UK primary care Rothnie KJ, Chandan JS, Goss HG, Müllerová H, Quint JK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1663-1668 Published Date: 7 June 2017

ORIGINAL RESEARCH

An analysis of the economic and patient outcome impact of an integrated COPD service in east London Garner A, Hodson M, Ketsetzis G, Pulle L, Yorke J, Bhowmik A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1653-1662 Published Date: 6 June 2017

ORIGINAL RESEARCH

Patient-perceived treatment burden of chronic obstructive pulmonary disease Harb N, Foster JM, Dobler CC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1641-1652 Published Date: 1 June 2017

ORIGINAL RESEARCH

Comparison of distinctive models for calculating an interlobar emphysema heterogeneity index in patients prior to endoscopic lung volume reduction Theilig D, Doellinger F, Poellinger A, Schreiter V, Neumann K, Hubner RH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1631-1640 Published Date: 1 June 2017

ORIGINAL RESEARCH

Serum inflammatory biomarkers and clinical outcomes of COPD exacerbation caused by different pathogens Kawamatawong T, Apiwattanaporn A, Siricharoonwong W International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1625-1630 Published Date: 31 May 2017

ORIGINAL RESEARCH

Radiologic features of precancerous areas of the lungs in chronic obstructive pulmonary disease Chubachi S, Takahashi S, Tsutsumi A, Kameyama N, Sasaki M, Naoki K, Soejima K, Nakamura H, Asano K, Betsuyaku T International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1613-1624 Published Date: 30 May 2017

ORIGINAL RESEARCH

Development of a nomogram for predicting in-hospital mortality of patients with exacerbation of chronic obstructive pulmonary disease Sakamoto Y, Yamauchi Y, Yasunaga H, Takeshima H, Hasegawa W, Jo T, Sasabuchi Y, Matsui H, Fushimi K, Nagase T International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1605-1611 Published Date: 29 May 2017

ORIGINAL RESEARCH

Expanding The INSPIRED COPD Outreach ProgramTM to the emergency department: a feasibility assessment Gillis D, Demmons J, Rocker G International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1597-1604 Published Date: 29 May 2017

ORIGINAL RESEARCH

Inhaled indacaterol for the treatment of COPD patients with destroyed lung by tuberculosis and moderate-to-severe airflow limitation: results from the randomized INFINITY study Kim CJ, Yoon HK, Park MJ, Yoo KH, Jung KS, Park JW, Lim SY, Shim JJ, Lee YC, Kim YS, Oh YM, Kim S, Yoo CG International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1589-1596 Published Date: 29 May 2017

ORIGINAL RESEARCH

Identifying the heterogeneity of COPD by V/P SPECT: a new tool for improving the diagnosis of parenchymal defects and grading the severity of small airways disease Bajc M, Chen Y, Wang J, Li XY, Shen WM, Wang CZ, Huang H, Lindqvist A, He XY International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1579-1587 Published Date: 26 May 2017

ORIGINAL RESEARCH

In vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy Ciciliani A, Langguth P, Wachtel H International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1565-1577 Published Date: 26 May 2017

ORIGINAL RESEARCH

Identification of thyroxine-binding globulin as a candidate plasma marker of chronic obstructive pulmonary disease Diao W, Shen N, Du Y, Sun X, Liu B, Xu M, He B International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1549-1564 Published Date: 25 May 2017

ORIGINAL RESEARCH

Delayed but successful response to noninvasive ventilation in COPD patients with acute hypercapnic respiratory failure Lemyze M, Bury Q, Guiot A, Jonard M, Mohammad U, Van Grunderbeeck N, Gasan G, Thevenin D, Mallat J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1539-1547 Published Date: 25 May 2017

ORIGINAL RESEARCH

A cross-sectional survey of current treatment and symptom burden of patients with COPD consulting for routine care according to GOLD 2014 classifications Ding B, Small M, Holmgren U International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1527-1537 Published Date: 23 May 2017

ORIGINAL RESEARCH

Proteasome activity related with the daily physical activity of COPD patients Lee KY, Chen TT, Chiang LL, Chuang HC, Feng PH, Liu WT, Chen KY, Ho SC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1519-1525 Published Date: 22 May 2017

ORIGINAL RESEARCH

Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK Maddi S, Kolsum U, Jackson S, Barraclough R, Maschera B, Simpson KD, Pascal TG, Durviaux S, Hessel EM, Singh D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1507-1518 Published Date: 22 May 2017

SHORT REPORT

Clinical characteristics of COPD patients with tidal expiratory flow limitation Dean J, Kolsum U, Hitchen P, Gupta V, Singh D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1503-1506 Published Date: 22 May 2017

ORIGINAL RESEARCH

The PLATINO study: description of the distribution, stability, and mortality according to the Global Initiative for Chronic Obstructive Lung Disease classification from 2007 to 2017 Menezes AM, Wehrmeister FC, Perez-Padilla R, Viana KP, Soares C, Müllerova H, Valdivia G, Jardim JR, Montes de Oca M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1491-1501 Published Date: 18 May 2017

ORIGINAL RESEARCH

Relationships between heart rate target determined in different exercise testing in COPD patients to prescribed with individualized exercise training Fabre C, Chehere B, Bart F, Mucci P, Wallaert B, Grosbois JM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1483-1489 Published Date: 16 May 2017

ORIGINAL RESEARCH

Development of a self-scored persistent airflow obstruction screening questionnaire in a general Japanese population: the Hisayama study Samukawa T, Matsumoto K, Tsukuya G, Koriyama C, Fukuyama S, Uchida A, Mizuno K, Miyahara H, Kiyohara Y, Ninomiya T, Inoue H International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1469-1481 Published Date: 15 May 2017

ORIGINAL RESEARCH

The effect of COPD severity and study duration on exacerbation outcome in randomized controlled trials Eriksson G, Calverley PM, Jenkins CR, Anzueto AR, Make BJ, Lindberg M, Fagerås M, Postma DS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1457-1468 Published Date: 15 May 2017

ORIGINAL RESEARCH

Two CHRN susceptibility variants for COPD are genetic determinants of emphysema and chest computed tomography manifestations in Chinese patients Zhao Z, Jiang C, Zhao D, Li Y, Liang CX, Liu W, Wei S, Zhou Y, Zhao Z, Ran P International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1447-1455 Published Date: 15 May 2017

ORIGINAL RESEARCH

Pulmonary artery to aorta ratio is associated with cardiac structure and functional changes in mild-to-moderate COPD Cuttica MJ, Bhatt SP, Rosenberg SR, Beussink L, Shah SJ, Smith LJ, Dransfield MT, Kalhan R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1439-1446 Published Date: 12 May 2017

ORIGINAL RESEARCH

Deterioration of quality of life is associated with the exacerbation frequency in individuals with alpha-1-antitrypsin deficiency – analysis from the German Registry Bernhard N, Lepper PM, Vogelmeier C, Seibert M, Wagenpfeil S, Bals R, Fähndrich S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1427-1437 Published Date: 12 May 2017

ORIGINAL RESEARCH

Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: a preliminary study Leelarungrayub J, Pinkaew D, Puntumetakul R, Klaphajone J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1415-1425 Published Date: 12 May 2017

LETTER

Blocking rhinoviral adhesion molecule (ICAM-1): potential to prevent COPD exacerbations Shukla SD, Hansbro PM, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1413-1414 Published Date: 11 May 2017

PERSPECTIVES

Bronchiectasis in COPD patients: more than a comorbidity? Martinez-Garcia MA, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1401-1411 Published Date: 11 May 2017

ORIGINAL RESEARCH

The direct and indirect costs of managing chronic obstructive pulmonary disease in Greece Souliotis K, Kousoulakou H, Hillas G, Tzanakis N, Toumbis M, Vassilakopoulos T International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1395-1400 Published Date: 10 May 2017

REVIEW

Genetic polymorphism and chronic obstructive pulmonary disease Yuan CH, Chang D, Lu GM, Deng XW International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1385-1393 Published Date: 10 May 2017

ORIGINAL RESEARCH

Bronchiectasis and increased risk of ischemic stroke: a nationwide population-based cohort study Chen YF, Lin HH, Lin CS, Turbat B, Wang KA, Chung WS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1375-1383 Published Date: 10 May 2017

ORIGINAL RESEARCH

Serum cytokine levels related to exposure to volatile organic compounds and PM2.5 in dwellings and workplaces in French farmers – a mechanism to explain nonsmoking COPD Audi C, Baïz N, Maesano CN, Ramousse O, Reboulleau D, Magnan A, Caillaud D, Annesi-Maesano I International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1363-1374 Published Date: 5 May 2017

ORIGINAL RESEARCH

Pri-microRNA-124 rs531564 polymorphism minor allele increases the risk of pulmonary artery hypertension by abnormally enhancing proliferation of pulmonary artery smooth muscle cells Li Q, Qian Z, Wang L International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1351-1361 Published Date: 4 May 2017

REVIEW

Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors? Hobbins S, Chapple ILC, Sapey E, Stockley RA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1339-1349 Published Date: 4 May 2017

ORIGINAL RESEARCH

The effect of indacaterol/glycopyrronium versus tiotropium or salmeterol/fluticasone on the prevention of clinically important deterioration in COPD Anzueto AR, Vogelmeier CF, Kostikas K, Mezzi K, Fucile S, Bader G, Shen S, Banerji D, Fogel R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1325-1337 Published Date: 4 May 2017

ORIGINAL RESEARCH

Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model Liu X, Ma C, Wang X, Wang W, Li Z, Wang X, Wang P, Sun W, Xue B International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1309-1324 Published Date: 2 May 2017

REVIEW

Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review Edgar RG, Patel M, Bayliss S, Crossley D, Sapey E, Turner AM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1295-1308 Published Date: 2 May 2017

ORIGINAL RESEARCH

Correlation between fractional exhaled nitric oxide and sputum eosinophilia in exacerbations of COPD Gao J, Zhang M, Zhou LQ, Yang X, Wu HG, Zhang JF, Wu F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1287-1293 Published Date: 27 April 2017

ORIGINAL RESEARCH

Home noninvasive positive pressure ventilation with built-in software in stable hypercapnic COPD: a short-term prospective, multicenter, randomized, controlled trial Zhou L, Li X, Guan L, Chen J, Guo B, Wu W, Huo Y, Zhou Z, Liang Z, Zhou Y, Tan J, Chen X, Song Y, Chen R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1279-1286 Published Date: 27 April 2017

ORIGINAL RESEARCH

Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis – report from a population-based study Sawalha S, Hedman L, Rönmark E, Lundbäck B, Lindberg A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1269-1277 Published Date: 24 April 2017

ORIGINAL RESEARCH

Pulmonary infection control window as a switching point for sequential ventilation in the treatment of COPD patients: a meta-analysis Lv Y, Lv Q, Lv Q, Lai T International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1255-1267 Published Date: 24 April 2017

ORIGINAL RESEARCH

Serum IL-1 and IL-17 levels in patients with COPD: associations with clinical parameters Zou Y, Chen X, Liu J, Zhou DB, Kuang X, Xiao J, Yu Q, Lu XX, Li W, Xie B, Chen Q International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1247-1254 Published Date: 24 April 2017

LETTER

Promoting the inclusion of vital-capacity data in the bronchodilator response Ben Saad H International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1243-1245 Published Date: 24 April 2017

ORIGINAL RESEARCH

COPD is a clear risk factor for increased use of resources and adverse outcomes in patients undergoing intervention for colorectal cancer: a nationwide study in Spain Baré M, Montón C, Mora L, Redondo M, Pont M, Escobar A, Sarasqueta C, Fernández de Larrea N, Briones E, Quintana JM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1233-1241 Published Date: 21 April 2017

ORIGINAL RESEARCH

Home monitoring of breathing rate in people with chronic obstructive pulmonary disease: observational study of feasibility, acceptability, and change after exacerbation Rubio N, Parker RA, Drost EM, Pinnock H, Weir CJ, Hanley J, Mantoani LC, McKinstry B, Rabinovich RA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1221-1231 Published Date: 20 April 2017

ORIGINAL RESEARCH

The association between risk of airflow limitation and serum uric acid measured at medical health check-ups Fukuhara A, Saito J, Sato S, Saito K, Fukuhara N, Tanino Y, Wang X, Rinno K, Suzuki H, Munakata M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1213-1219 Published Date: 19 April 2017

ORIGINAL RESEARCH

Relationship between lung function and grip strength in older hospitalized patients: a pilot study Holmes SJ, Allen SC, Roberts HC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1207-1212 Published Date: 19 April 2017

ORIGINAL RESEARCH

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD Thulborn SJ, Dilpazir M, Haldar K, Mistry V, Brightling CE, Barer MR, Bafadhel M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1199-1205 Published Date: 18 April 2017

ORIGINAL RESEARCH

Frailty syndrome in ambulatory patients with COPD Limpawattana P, Putraveephong S, Inthasuwan P, Boonsawat W, Theerakulpisut D, Chindaprasirt J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1193-1198 Published Date: 18 April 2017

ERRATUM

Characterization of sputum biomarkers for asthma–COPD overlap syndrome [Erratum] Gao J, Iwamoto H, Koskela J, Alenius H, Hattori N, Kohno N, Laitinen T, Mazur W, Pulkkinen V International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1191-1192 Published Date: 18 April 2017

ORIGINAL RESEARCH

Significance of NT-pro-BNP in acute exacerbation of COPD patients without underlying left ventricular dysfunction Adrish M, Nannaka VB, Cano EJ, Bajantri B, Diaz-Fuentes G International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1183-1189 Published Date: 13 April 2017

ORIGINAL RESEARCH

Self-reported daily walking time in COPD: relationship with relevant clinical and functional characteristics Ramon MA, Esquinas C, Barrecheguren M, Pleguezuelos E, Molina J, Quintano JA, Roman-Rodríguez M, Naberan K, Llor C, Roncero C, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1173-1181 Published Date: 13 April 2017

ORIGINAL RESEARCH

Self-rated health aspects among persons living with chronic obstructive pulmonary disease Halding A, Grov EK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1163-1172 Published Date: 12 April 2017

REVIEW

Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease Jiang Y, Wang X, Hu D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1153-1162 Published Date: 13 April 2017

ORIGINAL RESEARCH

Characteristics of COPD patients initiating treatment with aclidinium or tiotropium in primary care in Catalonia: a population-based study Monteagudo M, Roset M, Rodriguez-Blanco T, Muñoz L, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1145-1152 Published Date: 12 April 2017

ORIGINAL RESEARCH

Identification of subtypes in subjects with mild-to-moderate airflow limitation and its clinical and socioeconomic implications Lee JH, Rhee CK, Kim K, Kim J, Kim SH, Yoo K, Kim WJ, Park YB, Park HY, Jung KS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1135-1144 Published Date: 12 April 2017

PERSPECTIVES

Approaches to drug therapy for COPD in Russia: a proposed therapeutic algorithm Zykov KA, Ovcharenko SI International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1125-1133 Published Date: 11 April 2017

ORIGINAL RESEARCH

Long-term effects of beta-blocker use on lung function in Japanese patients with chronic obstructive pulmonary disease Oda N, Miyahara N, Ichikawa H, Tanimoto Y, Kajimoto K, Sakugawa M, Kawai H, Taniguchi A, Morichika D, Tanimoto M, Kanehiro A, Kiura K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1119-1124 Published Date: 10 April 2017

ORIGINAL RESEARCH

Accelerometer- versus questionnaire-based assessment of physical activity and their changes over time in patients with COPD Sievi NA, Brack T, Brutsche MH, Frey M, Irani S, Leuppi JD, Thurnheer R, Kohler M, Clarenbach CF International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1113-1118 Published Date: 10 April 2017

ORIGINAL RESEARCH

Peripheral leukocyte microRNAs as novel biomarkers for COPD Wang R, Xu J, Liu H, Zhao Z International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1101-1112 Published Date: 6 April 2017

ORIGINAL RESEARCH

Burden of asthma, dyspnea, and chronic cough in South Asia Bishwajit G, Tang S, Yaya S, Feng Z International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1093-1099 Published Date: 6 April 2017

ORIGINAL RESEARCH

Magnitude of exercise capacity and quality of life improvement following repeat pulmonary rehabilitation in patients with COPD Sandoz JS, Roberts MM, Cho JG, Wheatley JR International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1085-1091 Published Date: 6 April 2017

ORIGINAL RESEARCH

Risk of pneumonia with budesonide-containing treatments in COPD: an individual patient-level pooled analysis of interventional studies Hollis S, Jorup C, Lythgoe D, Martensson G, Regnell P, Eckerwall G International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1071-1084 Published Date: 5 April 2017

ORIGINAL RESEARCH

Pulmonary rehabilitation for COPD improves exercise time rather than exercise tolerance: effects and mechanisms Miki K, Maekura R, Kitada S, Miki M, Yoshimura K, Yamamoto H, Kawabe T, Kagawa H, Oshitani Y, Satomi A, Nishida K, Sawa N, Inoue K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1061-1070 Published Date: 3 April 2017

LETTER

Automated versus manual oxygen titration in COPD exacerbation: machine or hands, this is the question Karaoren G, Goksu Tomruk S, Esquinas AM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1057-1060 Published Date: 3 April 2017

ORIGINAL RESEARCH

Mid-regional pro-adrenomedullin and copeptin to predict short-term prognosis of COPD exacerbations: a multicenter prospective blinded study Dres M, Hausfater P, Foissac F, Bernard M, Joly LM, Sebbane M, Philippon AL, Gil-Jardiné C, Schmidt J, Maignan M, Treluyer JM, Roche N International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1047-1056 Published Date: 31 March 2017

CLINICAL TRIAL REPORT

Non-invasive ventilation with intelligent volume-assured pressure support versus pressurecontrolled ventilation: effects on the respiratory event rate and sleep quality in COPD with chronic hypercapnia Nilius G, Katamadze N, Domanski U, Schroeder M, Franke KJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1039-1045 Published Date: 30 March 2017

ORIGINAL RESEARCH

COPD is commonly underdiagnosed in patients with lung cancer: results from the RECOIL study (retrospective study of COPD infradiagnosis in lung cancer) Parrón Collar D, Pazos Guerra M, Rodriguez P, Gotera C, Mahíllo-Fernández I, Peces-Barba G, Seijo LM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1033-1038 Published Date: 30 March 2017

ORIGINAL RESEARCH

Barriers and enablers of physical activity engagement for patients with COPD in primary care Kosteli MC, Heneghan NR, Roskell C, Williams SE, Adab P, Dickens AP, Enocson A, Fitzmaurice DA, Jolly K, Jordan R, Greenfield S, Cumming J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1019-1031 Published Date: 28 March 2017

REVIEW

The recent advances of phenotypes in acute exacerbations of COPD Zhou A, Zhou Z, Zhao Y, Chen P International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1009-1018 Published Date: 27 March 2017

ORIGINAL RESEARCH

Cost-effectiveness analysis of umeclidinium/vilanterol for the management of patients with moderate to very severe COPD using an economic model Wilson MR, Patel JG, Coleman A, McDade CL, Stanford RH, Earnshaw SR International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:997-1008 Published Date: 24 March 2017

ORIGINAL RESEARCH

Factors contributing to high-cost hospital care for patients with COPD Mulpuru S, McKay J, Ronksley PE, Thavorn K, Kobewka DM, Forster AJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:989-995 Published Date: 24 March 2017

ORIGINAL RESEARCH

Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function Waschki B, Watz H, Holz O, Magnussen H, Olejnicka B, Welte T, Rabe KF, Janciauskiene S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:981-987 Published Date: 22 March 2017

ORIGINAL RESEARCH

Measures of bronchodilator response of FEV1, FVC and SVC in a Swedish general population sample aged 50–64 years, the SCAPIS Pilot Study Torén K, Bake B, Olin A-C, Engström G, Blomberg A, Vikgren J, Hedner J, Brandberg J, Persson HL, Sköld CM, Rosengren A, Bergström G, Janson C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:973-980 Published Date: 22 March 2017

ORIGINAL RESEARCH

Impact of a COPD comprehensive case management program on hospital length of stay and readmission rates Alshabanat A, Otterstatter MC, Sin DD, Road J, Rempel C, Burns J, van Eeden SF, FitzGerald JM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:961-971 Published Date: 21 March 2017

ORIGINAL RESEARCH

Intratracheal transplantation of endothelial progenitor cells attenuates smoking-induced COPD in mice Shi Z, Chen Y, Cao J, Zeng H, Yang Y, Chen P, Luo H, Peng H, Cai S, Guan C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:947-960 Published Date: 20 March 2017

CORRIGENDUM

Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study [Corrigendum] Dharmage SC, Perret JL, Burgess JA, Lodge CJ, Johns DP, Thomas PS, Giles GG, Hopper JL, Abramson MJ, Walters EH, Matheson MC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:945-946 Published Date: 20 March 2017

ORIGINAL RESEARCH

Greater dyspnea is associated with lower health-related quality of life among European patients with COPD Gruenberger JB, Vietri J, Keininger DL, Mahler DA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:937-944 Published Date: 20 March 2017

ORIGINAL RESEARCH

Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population Ding YP, Xu HP, Yao JJ, Xu DC, He P, Yi SY, Li QN, Liu YS, Wu CB, Tian ZJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:931-936 Published Date: 17 March 2017

REVIEW

A review of general pain measurement tools and instruments for consideration of use in COPD clinical practice Johnson AM, Smith SMS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:923-929 Published Date: 17 March 2017

ORIGINAL RESEARCH

LABA/LAMA combinations versus LAMA monotherapy or LABA/ICS in COPD: a systematic review and meta-analysis Rodrigo GJ, Price D, Anzueto A, Singh D, Altman P, Bader G, Patalano F, Fogel R, Kostikas K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:907-922 Published Date: 17 March 2017

ORIGINAL RESEARCH

Clinical application value of impulse oscillometry in geriatric patients with COPD Liu Z, Lin L, Liu X International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:897-905 Published Date: 15 March 2017

ORIGINAL RESEARCH

Evidence of eosinophil extracellular trap cell death in COPD: does it represent the trigger that switches on the disease? Uribe Echevarría L, Leimgruber C, García González J, Nevado A, Álvarez R, García LN, Quintar AA, Maldonado CA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:885-896 Published Date: 14 March 2017

ORIGINAL RESEARCH

Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation Tajti G, Gesztelyi R, Pak K, Papp C, Keki S, Szilasi ME, Mikaczo A, Fodor A, Szilasi M, Zsuga J International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:873-884 Published Date: 14 March 2017

ORIGINAL RESEARCH

Changes in the number of CD31−CD45−Sca-1+ cells and Shh signaling pathway involvement in the lungs of mice with emphysema and relevant effects of acute adenovirus infection Deng MH, Li JH, Gan Y, Chen Y, Chen P International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:861-872 Published Date: 14 March 2017

CORRIGENDUM

Health behaviors and their correlates among participants in the Continuing to Confront COPD International Patient Survey [Corrigendum] Müllerová H, Landis SH, Aisanov Z, Davis KJ, Ichinose M, Mannino DM, Maskell J, Menezes AM, van der Molen T, Oh YM, Tabberer M, Han MK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:859-860 Published Date: 15 March 2017

ORIGINAL RESEARCH

Is cardiac autonomic modulation during upper limb isometric contraction and Valsalva maneuver impaired in COPD patients? Goulart CL, Cabiddu R, Schneiders PB, Antunes San Martin E, Trimer R, Borghi-Silva A, da Silva ALG International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:849-857 Published Date: 13 March 2017

ORIGINAL RESEARCH

Colds as predictors of the onset and severity of COPD exacerbations Johnston NW, Olsson M, Edsbäcker S, Gerhardsson de Verdier M, Gustafson P, McCrae C, Coyle PV, McIvor RA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:839-848 Published Date: 10 March 2017

ORIGINAL RESEARCH

Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency? Carleo A, Chorostowska-Wynimko J, Koeck T, Mischak H, Czajkowska-Malinowska M, Rozy A, Welte T, Janciauskiene S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:829-837 Published Date: 8 March 2017

ORIGINAL RESEARCH

Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice Lee B, Ko E, Lee J, Jo Y, Hwang H, Goh TS, Joo M, Hong C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:817-827 Published Date: 8 March 2017

LETTER

The Barthel index-dyspnea a tool for respiratory rehabilitation: reply to the letter by Chuang [Letter of clarification] Carone M, Vitacca M, Paneroni M, Baiardi P, Spanevello A, Bertolotti G International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:813-815 Published Date: 8 March 2017

REVIEW

Mucoactive and antioxidant medicines for COPD: consensus of a group of Chinese pulmonary physicians Yan X, Song Y, Shen C, Xu WB, Chen L, Zhang J, Liu H, Huang M, Lai G, Qian G, Wang J, Ye X, Zheng J, Bai C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:803-812 Published Date: 22 March 2017

ORIGINAL RESEARCH

Inhaled treatment of COPD: a Delphi consensus statement Ninane V, Corhay JL, Germonpré P, Janssens W, Joos GF, Liistro G, Vincken W, Gurdain S, Vanvlasselaer E, Lehouck A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:793-801 Published Date: 6 March 2017

ORIGINAL RESEARCH

Seasonal variability in clinical care of COPD outpatients: results from the Andalusian COPD audit López-Campos JL, Abad Arranz M, Calero-Acuña C, Romero-Valero F, Ayerbe-García R, Hidalgo-Molina A, AguilarPérez-Grovas RI, García-Gil F, Casas-Maldonado F, Caballero-Ballesteros L, Sánchez-Palop M, Pérez-Tejero D, Segado Soriano A, Calvo-Bonachera J, Hernández-Sierra B, Doménech A, Arroyo-Varela M, González-Vargas F, Cruz-Rueda JJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:785-792 Published Date: 3 March 2017

LETTER

Community-acquired pneumonia and survival of critically ill acute exacerbation of COPD patients in respiratory intensive care units Takir HB, Esquinas AM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:783-784 Published Date: 2 March 2017

ORIGINAL RESEARCH

Transdiaphragmatic pressure and neural respiratory drive measured during inspiratory muscle training in stable patients with chronic obstructive pulmonary disease Wu W, Zhang X, Lin L, Ou Y, Li X, Guan L, Guo B, Zhou L, Chen R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:773-781 Published Date: 2 March 2017

ORIGINAL RESEARCH

Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease Sugiyama Y, Asai K, Yamada K, Kureya Y, Ijiri N, Watanabe T, Kanazawa H, Hirata K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:765-772 Published Date: 2 March 2017

ORIGINAL RESEARCH

The effect of obesity on patients with mild chronic obstructive pulmonary disease: results from KNHANES 2010 to 2012 Park JH, Lee JK, Heo EY, Kim DK, Chung HS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:757-763 Published Date: 24 February 2017

ORIGINAL RESEARCH

Umeclidinium/vilanterol as step-up therapy from tiotropium in patients with moderate COPD: a randomized, parallel-group, 12-week study Kerwin EM, Kalberg CJ, Galkin DV, Zhu C, Church A, Riley JH, Fahy WA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:745-755 Published Date: 24 February 2017

ORIGINAL RESEARCH

Impact of comorbid conditions in COPD patients on health care resource utilization and costs in a predominantly Medicare population Schwab P, Dhamane AD, Hopson SD, Moretz C, Annavarapu S, Burslem K, Renda A, Kaila S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:735-744 Published Date: 23 February 2017

REVIEW

Occupational COPD and job exposure matrices: a systematic review and meta-analysis Sadhra S, Kurmi OP, Sadhra SS, Lam KB, Ayres JG International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:725-734 Published Date: 22 February 2017

ORIGINAL RESEARCH

Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model Sun J, Bao J, Shi Y, Zhang B, Yuan L, Li J, Zhang L, Sun M, Zhang L, Sun W International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:717-724 Published Date: 22 February 2017

ORIGINAL RESEARCH

Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD Shen W, Liu J, Zhao G, Fan M, Song G, Zhang Y, Weng Z, Zhang Y International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:705-715 Published Date: 22 February 2017

ORIGINAL RESEARCH

Heterogeneity of asthma–COPD overlap syndrome Joo H, Han D, Lee JH, Rhee CK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:697-703 Published Date: 22 February 2017

ORIGINAL RESEARCH

The immediate effect of soft tissue manual therapy intervention on lung function in severe chronic obstructive pulmonary disease Cruz-Montecinos C, Godoy-Olave D, Contreras-Briceño FA, Gutiérrez P, Torres-Castro R, Miret-Venegas L, Engel RM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:691-696 Published Date: 21 February 2017

ORIGINAL RESEARCH

COPD symptom burden: impact on health care resource utilization, and work and activity impairment Ding B, Small M, Bergström G, Holmgren U International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:677-689 Published Date: 21 February 2017

ORIGINAL RESEARCH

Sarcopenia correlates with systemic inflammation in COPD Byun MK, Cho EN, Chang J, Ahn CM, Kim HJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:669-675 Published Date: 20 February 2017

ORIGINAL RESEARCH

Natural course of early COPD Rhee CK, Kim K, Yoon HK, Kim JA, Kim SH, Lee SH, Park YB, Jung KS, Yoo KH, Hwang YI International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:663-668 Published Date: 20 February 2017

ORIGINAL RESEARCH

Chronic rhinosinusitis is associated with higher prevalence and severity of bronchiectasis in patients with COPD Yang X, Xu YL, Jin JM, Li RM, Liu XF, Sun YC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:655-662 Published Date: 20 February 2017

LETTER

Is exposure to biomass smoke really associated with COPD? Das V, Nitin V, Salvi S, Kodgule R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:651-653 Published Date: 17 February 2017

REVIEW

Recognition, diagnosis, and treatment of cognitive and psychiatric disorders in patients with COPD Ouellette DR, Lavoie KL International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:639-650 Published Date: 16 February 2017

ORIGINAL RESEARCH

MiR-344b-1-3p targets TLR2 and negatively regulates TLR2 signaling pathway Xu H, Wu Y, Li L, Yuan W, Zhang D, Yan Q, Guo Z, Huang W International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:627-638 Published Date: 14 February 2017

ORIGINAL RESEARCH

Can we predict the prognosis of COPD with a routine blood test? Xiong W, Xu M, Zhao YF, Wu XL, Pudasaini B, Liu JM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:615-625 Published Date: 13 February 2017

ORIGINAL RESEARCH

A Belgian survey on the diagnosis of asthma–COPD overlap syndrome Cataldo D, Corhay JL, Derom E, Louis R, Marchand E, Michils A, Ninane V, Peché R, Pilette C, Vincken W, Janssens W International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:601-613 Published Date: 13 February 2017

ORIGINAL RESEARCH

A cross-sectional survey of night-time symptoms and impact of sleep disturbance on symptoms and health status in patients with COPD Ding B, Small M, Bergström G, Holmgren U International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:589-599 Published Date: 13 February 2017

ORIGINAL RESEARCH

Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD Ma R, Gong XF, Jiang H, Lin CY, Chen YQ, Xu XM, Zhang CT, Wang J, Lu WJ, Zhong NS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:581-587 Published Date: 20 February 2017

ORIGINAL RESEARCH

Incidence and long-term outcome of severe asthma–COPD overlap compared to asthma and COPD alone: a 35-year prospective study of 57,053 middle-aged adults Baarnes CB, Andersen ZJ, Tjønneland A, Ulrik CS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:571-579 Published Date: 10 February 2017

ORIGINAL RESEARCH

Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update Blanco I, Bueno P, Diego I, Pérez-Holanda S, Casas-Maldonado F, Esquinas C, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:561-569 Published Date: 13 February 2017

ORIGINAL RESEARCH

Longitudinal changes in structural abnormalities using MDCT in COPD: do the CT measurements of airway wall thickness and small pulmonary vessels change in parallel with emphysematous progression? Takayanagi S, Kawata N, Tada Y, Ikari J, Matsuura Y, Matsuoka S, Matsushita S, Yanagawa N, Kasahara Y, Tatsumi K International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:551-560 Published Date: 13 February 2017

ORIGINAL RESEARCH

Airway gene expression of IL-1 pathway mediators predicts exacerbation risk in obstructive airway disease Baines KJ, Fu JJ, McDonald VM, Gibson PG International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:541-550 Published Date: 8 February 2017

ORIGINAL RESEARCH

A cross-sectional assessment of the burden of COPD symptoms in the US and Europe using the National Health and Wellness Survey Ding B, DiBonaventura M, Karlsson N, Bergström G, Holmgren U International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:529-539 Published Date: 7 February 2017

ORIGINAL RESEARCH

Asthma–COPD overlap syndrome in the US: a prospective population-based analysis of patientreported outcomes and health care utilization Vaz Fragoso CA, Murphy TE, Agogo GO, Allore HG, McAvay GJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:517-527 Published Date: 3 February 2017

ORIGINAL RESEARCH

Impact of exacerbations on respiratory system impedance measured by a forced oscillation technique in COPD: a prospective observational study Kamada T, Kaneko M, Tomioka H International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:509-516 Published Date: 3 February 2017

ORIGINAL RESEARCH

Longitudinal changes in lung hyperinflation in COPD Park J, Lee CH, Lee YJ, Park JS, Cho YJ, Lee JH, Lee CT, Yoon HI International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:501-508 Published Date: 3 February 2017

ORIGINAL RESEARCH

Health status and lung function in the Swedish alpha 1-antitrypsin deficient cohort, identified by neonatal screening, at the age of 37-40 years Piitulainen E, Mostafavi B, Tanash HA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:495-500 Published Date: 2 February 2017

CLINICAL TRIAL REPORT

“Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD Vogelmeier C, Worth H, Buhl R, Criée C, Lossi NS, Mailänder C, Kardos P International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:487-494 Published Date: 1 February 2017

ORIGINAL RESEARCH

Long-acting bronchodilators with or without inhaled corticosteroids and 30-day readmission in patients hospitalized for COPD Bishwakarma R, Zhang W, Kuo YF, Sharma G International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:477-486 Published Date: 31 January 2017

ORIGINAL RESEARCH

Determining prognosis in acute exacerbation of COPD Flattet Y, Garin N, Serratrice J, Perrier A, Stirnemann J, Carballo S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:467-475 Published Date: 31 January 2017

ORIGINAL RESEARCH

The pharmacological cost of COPD during Greek economic crisis Stafyla E, Kerenidi T, Gerogianni I, Geitona M, Daniil Z, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:461-466 Published Date: 31 January 2017

ORIGINAL RESEARCH

Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy Martin M, Almeras N, Després JP, Coxson HO, Washko GR, Vivodtzev I, Wouters EFM, Rutten E, Williams MC, Murchison JT, MacNee W, Sin DD, Maltais F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:451-460 Published Date: 31 January 2017

ORIGINAL RESEARCH

Lung and kidney: a dangerous liaison? A population-based cohort study in COPD patients in Italy Fedeli U, De Giorgi A, Gennaro N, Ferroni E, Gallerani M, Mikhailidis DP, Manfredini R, Fabbian F International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:443-450 Published Date: 27 January 2017

ORIGINAL RESEARCH

Risk factors for FEV1 decline in mild COPD and high-risk populations Chen SJ, Wang CH, Li B, Shi GC, Li HP, Zhang J, Gu YT, Zhou J, Song YL, Bai CX International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:435-442 Published Date: 27 January 2017

ORIGINAL RESEARCH

Patterns and characterization of COPD exacerbations using real-time data collection Ejiofor SI, Stolk J, Fernandez P, Stockley RA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:427-434 Published Date: 25 January 2017

ORIGINAL RESEARCH

Clinical audit of COPD in outpatient respiratory clinics in Spain: the EPOCONSUL study Calle Rubio M, Alcazar-Navarrete B, Soriano JB, Soler-Cataluña JJ, Rodriguez González-Moro JM, Fuentes Ferrer ME, Lopez-Campos JL International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:417-426 Published Date: 25 January 2017

REVIEW

“What are my chances of developing COPD if one of my parents has the disease?” A systematic review and meta-analysis of prevalence of co-occurrence of COPD diagnosis in parents and offspring Li LSK, Paquet C, Johnston K, Williams MT International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:403-415 Published Date: 24 January 2017

ORIGINAL RESEARCH

Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease Kim SW, Rhee CK, Kim KU, Lee SH, Hwang HG, Kim YI, Kim DK, Lee SD, Oh YM, Yoon HK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:395-402 Published Date: 21 January 2017

ORIGINAL RESEARCH

Coil therapy for patients with severe emphysema and bilateral incomplete fissures – effectiveness and complications after 1-year follow-up: a single-center experience Kontogianni K, Gerovasili V, Gompelmann D, Schuhmann M, Hoffmann H, Heussel CP, Herth FJF, Eberhardt R International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:383-394 Published Date: 23 January 2017

ORIGINAL RESEARCH

Comparative efficacy of long-acting 2-agonists as monotherapy for chronic obstructive pulmonary disease: a network meta-analysis Donohue JF, Betts KA, Du EX, Altman P, Goyal P, Keininger DL, Gruenberger JB, Signorovitch JE International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:367-381 Published Date: 19 January 2017

ORIGINAL RESEARCH

A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD Bhatt SP, Dransfield MT, Cockcroft JR, Wang-Jairaj J, Midwinter DA, Rubin DB, Scott-Wilson CA, Crim C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:351-365 Published Date: 19 January 2017

ORIGINAL RESEARCH

Indacaterol/glycopyrronium versus salmeterol/fluticasone in Asian patients with COPD at a high risk of exacerbations: results from the FLAME study Wedzicha JA, Zhong N, Ichinose M, Humphries M, Fogel R, Thach C, Patalano F, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:339-349 Published Date: 19 January 2017

ORIGINAL RESEARCH

Prevalence of swallowing dysfunction screened in Swedish cohort of COPD patients Gonzalez Lindh M, Blom Johansson M, Jennische M, Koyi H International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:331-337 Published Date: 17 January 2017

ORIGINAL RESEARCH

The role of tuberculosis in COPD Yakar HI, Gunen H, Pehlivan E, Aydogan S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:323-329 Published Date: 17 January 2017

ORIGINAL RESEARCH

Seasonality, risk factors and burden of community-acquired pneumonia in COPD patients: a population database study using linked health care records Williams NP, Coombs NA, Johnson MJ, Josephs LK, Rigge LA, Staples KJ, Thomas M, Wilkinson TMA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:313-322 Published Date: 17 January 2017

ORIGINAL RESEARCH

The view of pulmonologists on palliative care for patients with COPD: a survey study Duenk RG, Verhagen C, Dekhuijzen PNR, Vissers KCP, Engels Y, Heijdra Y International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:299-311 Published Date: 17 January 2017

ORIGINAL RESEARCH

Evaluation of carbon dioxide rebreathing during exercise assisted by noninvasive ventilation with plateau exhalation valve Ou YE, Lin ZM, Hua DM, Jiang Y, Huo YT, Luo Q, Chen RC International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:291-298 Published Date: 16 January 2017

ORIGINAL RESEARCH

Real-life data on antibiotic prescription and sputum culture diagnostics in acute exacerbations of COPD in primary care Bathoorn E, Groenhof F, Hendrix R, van der Molen T, Sinha B, Kerstjens HA, Friedrich AW, Kocks JW International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:285-290 Published Date: 13 January 2017

ORIGINAL RESEARCH

Predicting high risk of exacerbations in bronchiectasis: the E-FACED score Martinez-Garcia MA, Athanazio RA, Girón R, Máiz-Carro L, de la Rosa D, Olveira C, de Gracia J, Vendrell M, Prados-Sánchez C, Gramblicka G, Corso Pereira M, Lundgren FL, Fernandes de Figuereido M, Arancibia F, Rached SZ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:275-284 Published Date: 18 January 2017

ORIGINAL RESEARCH

Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNA Wu L, Zhang J, Qu JM, Bai CX, Merrilees MJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:267-273 Published Date: 12 January 2017

ORIGINAL RESEARCH

Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study Deng XW, Yuan CH, Chang D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:259-265 Published Date: 11 January 2017

ORIGINAL RESEARCH

Respiratory muscle activity and patient–ventilator asynchrony during different settings of noninvasive ventilation in stable hypercapnic COPD: does high inspiratory pressure lead to respiratory muscle unloading? Duiverman ML, Huberts AS, van Eykern LA, Bladder G, Wijkstra PJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:243-257 Published Date: 11 January 2017

ORIGINAL RESEARCH

Birmingham COPD Cohort: a cross-sectional analysis of the factors associated with the likelihood of being in paid employment among people with COPD Rai KK, Jordan RE, Siebert WS, Sadhra SS, Fitzmaurice DA, Sitch AJ, Ayres JG, Adab P International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:233-242 Published Date: 11 January 2017

CORRIGENDUM

Efficacy and safety of indacaterol/glycopyrronium in Japanese patients with COPD: a subgroup analysis from the SHINE study [Corrigendum] Hashimoto S, Ikeuchi H, Murata S, Kitawaki T, Ikeda K, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:231-232 Published Date: 10 January 2017

CORRIGENDUM

Comparison of the clinical characteristics and treatment outcomes of patients requiring hospital admission to treat eosinophilic and neutrophilic exacerbations of COPD [Corrigendum] Kang HS, Rhee CK, Kim SK, Kim JW, Lee SH, Yoon HK, Ahn JH, Kim YH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:229-230 Published Date: 11 January 2017

CORRIGENDUM

Comparative analysis of budesonide/formoterol and fluticasone/salmeterol combinations in COPD patients: findings from a real-world analysis in an Italian setting [Corrigendum] Perrone V, Sangiorgi D, Buda S, Degli Esposti L International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:227-228 Published Date: 10 January 2017

ORIGINAL RESEARCH

Global scientific collaboration in COPD research Su YB, Long C, Yu Q, Zhang J, Wu D, Duan ZG International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:215-225 Published Date: 6 January 2017

ORIGINAL RESEARCH

Inverse relationship between nonadherence to original GOLD treatment guidelines and exacerbations of COPD Foda HD, Brehm A, Goldsteen K, Edelman NH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:209-214 Published Date: 6 January 2017

ORIGINAL RESEARCH

Serum CCL-18 level is a risk factor for COPD exacerbations requiring hospitalization Dilektasli AG, Demirdogen Cetinoglu E, Uzaslan E, Budak F, Coskun F, Ursavas A, Ercan I, Ege E International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:199-208 Published Date: 5 January 2017

ORIGINAL RESEARCH

Burn injury during long-term oxygen therapy in Denmark and Sweden: the potential role of smoking Tanash HA, Ringbaek T, Huss F, Ekström M International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:193-197 Published Date: 5 January 2017

LETTER

The need for greater opioid pharmacovigilance in COPD Vozoris NT International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:189-192 Published Date: 6 January 2017

ORIGINAL RESEARCH

Flexible bronchoscopy with moderate sedation in COPD: a case–control study Grendelmeier P, Tamm M, Jahn K, Pflimlin E, Stolz D International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:177-187 Published Date: 4 January 2017

ORIGINAL RESEARCH

Increased brachial intima-media thickness is associated with circulating levels of asymmetric dimethylarginine in patients with COPD Urban MH, Eickhoff P, Funk GC, Burghuber OC, Wolzt M, Valipour A International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:169-176 Published Date: 4 January 2017

REVIEW

Dual bronchodilation in COPD: lung function and patient-reported outcomes – a review Price D, Østrem A, Thomas M, Welte T International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:141-168 Published Date: 30 December 2016

REVIEW

Spotlight on fluticasone furoate/umeclidinium/vilanterol in COPD: design, development, and potential place in therapy Lal C, Strange C International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:135-140 Published Date: 30 December 2016

ORIGINAL RESEARCH

Barriers and facilitators influencing self-management among COPD patients: a mixed methods exploration in primary and affiliated specialist care Hillebregt CF, Vlonk AJ, Bruijnzeels MA, van Schayck OCP, Chavannes NH International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:123-133 Published Date: 23 December 2016

ORIGINAL RESEARCH

Association between adherence to medications for COPD and medications for other chronic conditions in COPD patients Dhamane AD, Schwab P, Hopson S, Moretz C, Annavarapu S, Burslem K, Renda A, Kaila S International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:115-122 Published Date: 22 December 2016

ORIGINAL RESEARCH

Psychometric properties of the Physical Activity Scale for the Elderly in Chinese patients with COPD Tao YX, Wang L, Dong XY, Zheng H, Zheng YS, Tang XY, Zhao Y, Zhang Q International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:105-114 Published Date: 22 December 2016

ORIGINAL RESEARCH

Gender differences in partners of patients with COPD and their perceptions about the patients Nakken N, Janssen DJA, van Vliet M, de Vries GJ, Clappers-Gielen GAL, Michels AJ, Muris JWM, Vercoulen JH, Wouters EFM, Spruit MA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:95-104 Published Date: 23 December 2016

ORIGINAL RESEARCH

Network pharmacology-based identification of key pharmacological pathways of Yin–Huang– Qing–Fei capsule acting on chronic bronchitis Yu GH, Zhang YQ, Ren WQ, Dong L, Li JF, Geng Y, Zhang Y, Li DF, Xu HY, Yang HJ International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:85-94 Published Date: 22 December 2016

ORIGINAL RESEARCH

Initiation of triple therapy maintenance treatment among patients with COPD in the US Simeone JC, Luthra R, Kaila S, Pan X, Bhagnani TD, Liu J, Wilcox TK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:73-83 Published Date: 22 December 2016

ORIGINAL RESEARCH

The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes Bosnic-Anticevich S, Chrystyn H, Costello RW, Dolovich MB, Fletcher MJ, Lavorini F, Rodríguez-Roisin R, Ryan D, Wan Yau Ming S, Price DB International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:59-71 Published Date: 21 December 2016

ORIGINAL RESEARCH

Psychometric properties of the Anxiety Inventory for Respiratory Disease in patients with COPD in China Dong X, Wang L, Tao Y, Suo X, Li Y, Liu F, Zhao Y, Zhang Q International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:49-58 Published Date: 20 December 2016

ORIGINAL RESEARCH

Gender differences in the T-cell profiles of the airways in COPD patients associated with clinical phenotypes Forsslund H, Yang M, Mikko M, Karimi R, Nyrén S, Engvall B, Grunewald J, Merikallio H, Kaarteenaho R, Wahlström J, Wheelock ÅM, Sköld CM International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:35-48 Published Date: 20 December 2016

ORIGINAL RESEARCH

Trend of cost and utilization of COPD medication in Korea Lee J, Lee JH, Kim J, Rhee CK International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:27-33 Published Date: 19 December 2016

ORIGINAL RESEARCH

Early efficacy of budesonide/formoterol in patients with moderate-to-very-severe COPD Calverley PM, Eriksson G, Jenkins CR, Anzueto AR, Make BJ, Persson A, Fagerås M, Postma DS International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:13-25 Published Date: 19 December 2016

ORIGINAL RESEARCH

Domain-specific cognitive impairment in patients with COPD and control subjects Cleutjens FAHM, Franssen FME, Spruit MA, Vanfleteren LEGW, Gijsen C, Dijkstra JB, Ponds RWHM, Wouters EFM, Janssen DJA International Journal of Chronic Obstructive Pulmonary Disease 2017, 12:1-11 Published Date: 19 December 2016

ORIGINAL RESEARCH

The administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to cigarette smoke Pena KB, Ramos CO, Soares NP, Silva PF, Bandeira ACB, Costa GP, Cangussú SD, Talvani A, Bezerra FS International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3207-3217 Published Date: 15 December 2016

ORIGINAL RESEARCH

Rates and predictors of depression status among caregivers of patients with COPD hospitalized for acute exacerbations: a prospective study Bernabeu-Mora R, García-Guillamón G, Montilla-Herrador J, Escolar-Reina P, García-Vidal JA, Medina-Mirapeix F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3199-3205 Published Date: 14 December 2016

ORIGINAL RESEARCH

Indacaterol/glycopyrronium in symptomatic patients with COPD (GOLD B and GOLD D) versus salmeterol/fluticasone: ILLUMINATE/LANTERN pooled analysis Vogelmeier C, Zhong NS, Humphries MJ, Mezzi K, Fogel R, Bader G, Patalano F, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3189-3197 Published Date: 14 December 2016

REVIEW

Endocan and the respiratory system: a review Kechagia M, Papassotiriou I, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3179-3187 Published Date: 12 December 2016

REVIEW

Efficacy of tiotropium–olodaterol fixed-dose combination in COPD Derom E, Brusselle GG, Joos GF International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3163-3177 Published Date: 13 December 2016

ORIGINAL RESEARCH

Prognostic utility of admission cell-free DNA levels in patients with chronic obstructive pulmonary disease exacerbations Avriel A, Rozenberg D, Raviv Y, Heimer D, Bar-Shai A, Gavish R, Sheynin J, Douvdevani A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3153-3161 Published Date: 9 December 2016

ORIGINAL RESEARCH

Drop in lung function during asthma and COPD exacerbations – can it be assessed without spirometry? Melbye H, Al-ani S, Spigt M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3145-3152 Published Date: 8 December 2016

ORIGINAL RESEARCH

COPD assessment test score and serum C-reactive protein level in stable COPD patients Kang HK, Kim K, Lee H, Jeong BH, Koh WJ, Park HY International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3137-3143 Published Date: 8 December 2016

REVIEW

Exercise training alone or with the addition of activity counseling improves physical activity levels in COPD: a systematic review and meta-analysis of randomized controlled trials Lahham A, McDonald CF, Holland AE International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3121-3136 Published Date: 8 December 2016

ORIGINAL RESEARCH

How do general practitioners implement decision-making regarding COPD patients with exacerbations? An international focus group study Laue J, Melbye H, Halvorsen PA, Andreeva EA, Godycki-Cwirko M, Wollny A, Francis NA, Spigt M, Kung K, Risør MB International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3109-3119 Published Date: 8 December 2016

ORIGINAL RESEARCH

An evaluation of early medication use for COPD: a population-based cohort study Falk J, Dik N, Bugden S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3101-3108 Published Date: 7 December 2016

ORIGINAL RESEARCH

Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves Gompelmann D, Benjamin N, Kontogianni K, Herth FJF, Heussel CP, Hoffmann H, Eberhardt R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3093-3099 Published Date: 7 December 2016

ORIGINAL RESEARCH

Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis Li JH, Sun SZ, Tang R, Qiu H, Huang QY, Mason TG, Tian LW International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3079-3091 Published Date: 12 December 2016

REVIEW

Interpreting patient-reported outcomes from clinical trials in COPD: a discussion Jones PW, Rennard S, Tabberer M, Riley JH, Vahdati-Bolouri M, Barnes NC International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3069-3078 Published Date: 7 December 2016

ORIGINAL RESEARCH

Exacerbations and health care resource utilization in patients with airflow limitation diseases attending a primary care setting: the PUMA study Montes de Oca M, Aguirre C, Lopez Varela MV, Laucho-Contreras ME, Casas A, Surmont F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3059-3067 Published Date: 7 December 2016

ORIGINAL RESEARCH

Increased risk of community-acquired pneumonia in COPD patients with comorbid cardiovascular disease Lin SH, Perng DW, Chen CP, Chai WH, Yeh CS, Kor CT, Cheng SL, Chen JJ, Lin CH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3051-3058 Published Date: 5 December 2016

REVIEW

Effects of aclidinium on determinants of COPD severity: symptoms and quality of life Contoli M, Solidoro P, Di Marco F, Scichilone N, Corsico A, Braido F, Santus P International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3043-3050 Published Date: 5 December 2016

ORIGINAL RESEARCH

Cigarette smoke extract induces placental growth factor release from human bronchial epithelial cells via ROS/MAPK(ERK-1/2)/Egr-1 axis Wu D, Yuan Y, Lin Z, Lai T, Chen M, Li W, Lv Q, Yuan B, Li D, Wu B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3031-3042 Published Date: 2 December 2016

ORIGINAL RESEARCH

Clinical factors and comorbidities affecting the cost of hospital-treated COPD Deniz S, Şengül A, Aydemir Y, Çeldir Emre J, Özhan MH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3023-3030 Published Date: 2 December 2016

ORIGINAL RESEARCH

Computer quantification of “angle of collapse” on maximum expiratory flow volume curve for diagnosing asthma-COPD overlap syndrome Wang W, Xie M, Dou S, Cui L, Xiao W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3015-3022 Published Date: 1 December 2016

REVIEW

Airflow obstruction: is it asthma or is it COPD? Rogliani P, Ora J, Puxeddu E, Cazzola M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3007-3013 Published Date: 30 November 2016

ORIGINAL RESEARCH

Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey Lee CH, Goag EK, Lee SH, Chung KS, Jung JY, Park MS, Kim YS, Kim SK, Chang J, Song JH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3001-3006 Published Date: 29 November 2016

ORIGINAL RESEARCH

Three-minute constant rate step test for detecting exertional dyspnea relief after bronchodilation in COPD Borel B, Wilkinson-Maitland CA, Hamilton A, Bourbeau J, Perrault H, Jensen D, Maltais F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2991-3000 Published Date: 29 November 2016

ORIGINAL RESEARCH

Factors influencing exacerbation-related self-management in patients with COPD: a qualitative study Korpershoek YJG, Vervoort SCJM, Nijssen LIT, Trappenburg JCA, Schuurmans MJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2977-2990 Published Date: 28 November 2016

ORIGINAL RESEARCH

Effectiveness of neuromuscular electrical stimulation for the rehabilitation of moderate-to-severe COPD: a meta-analysis Chen R, Li X, Guan L, Guo B, Wu W, Zhou Z, Huo Y, Chen X, Zhou L International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2965-2975 Published Date: 28 November 2016

ORIGINAL RESEARCH

Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF- induction in patients with COPD Tang WX, Shen ZY, Guo J, Sun SH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2951-2964 Published Date: 28 November 2016

ORIGINAL RESEARCH

Bronchodilator response of advanced lung function parameters depending on COPD severity Jarenbäck L, Eriksson G, Peterson S, Ankerst J, Bjermer L, Tufvesson E International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2939-2950 Published Date: 25 November 2016

REVIEW

Coherence between self-reported and objectively measured physical activity in patients with chronic obstructive lung disease: a systematic review Thyregod M, Bodtger U International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2931-2938 Published Date: 25 November 2016

ORIGINAL RESEARCH

Outcomes of a telemonitoring-based program (telEPOC) in frequently hospitalized COPD patients Esteban C, Moraza J, Iriberri M, Aguirre U, Goiria B, Quintana JM, Aburto M, Capelastegui A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2919-2930 Published Date: 24 November 2016

CASE REPORT

Significant lung volume reduction with endobronchial valves in a patient despite the presence of microcollaterals masked by low-flow Chartis phenotype Yin Y, Hou G, Herth FJ, Wang X, Wang Q, Kang J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2913-2917 Published Date: 24 November 2016

LETTER

Superiority of tiotropium plus olodaterol in comparison with salmeterol plus fluticasone Tamura T, Satoh H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2909-2911 Published Date: 23 November 2016

ORIGINAL RESEARCH

Impact of a care pathway for COPD on adherence to guidelines and hospital readmission: a cluster randomized trial Vanhaecht K, Lodewijckx C, Sermeus W, Decramer M, Deneckere S, Leigheb F, Boto P, Kul S, Seys D, Panella M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2897-2908 Published Date: 23 November 2016

METHODOLOGY

Randomized controlled trials and real-world observational studies in evaluating cardiovascular safety of inhaled bronchodilator therapy in COPD Kardos P, Worsley S, Singh D, Román-Rodríguez M, Newby DE, Müllerová H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2885-2895 Published Date: 25 November 2016

ORIGINAL RESEARCH

Effect of ELOM-080 on exacerbations and symptoms in COPD patients with a chronic bronchitis phenotype – a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial Beeh KM, Beier J, Candler H, Wittig T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2877-2884 Published Date: 23 November 2016

ORIGINAL RESEARCH

Usefulness of the 6-minute walk test as a screening test for pulmonary arterial enlargement in COPD Oki Y, Kaneko M, Fujimoto Y, Sakai H, Misu S, Mitani Y, Yamaguchi T, Yasuda H, Ishikawa A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2869-2875 Published Date: 22 November 2016

ORIGINAL RESEARCH

Bronchodilator efficacy of 18 µg once-daily tiotropium inhalation via Discair® versus HandiHaler® in adults with chronic obstructive pulmonary disease: randomized, activecontrolled, parallel-group, open-label, Phase IV trial Yildiz P, Bayraktaroglu M, Gorgun D, Secik F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2859-2867 Published Date: 22 November 2016

ORIGINAL RESEARCH

The burden of chronic obstructive pulmonary disease associated with maintenance monotherapy in the UK Edwards SC, Fairbrother SE, Scowcroft A, Chiu G, Ternouth A, Lipworth BJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2851-2858 Published Date: 22 November 2016

ORIGINAL RESEARCH

Community-based exercise training for people with chronic respiratory and chronic cardiac disease: a mixed-methods evaluation McNamara RJ, McKeough ZJ, Mo LR, Dallimore JT, Dennis SM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2839-2850 Published Date: 16 November 2016

ORIGINAL RESEARCH

COPD care delivery pathways in five European Union countries: mapping and health care professionals’ perceptions Kayyali R, Odeh B, Frerichs I, Davies N, Perantoni E, D'arcy S, Vaes AW, Chang J, Spruit MA, Deering B, Philip N, Siva R, Kaimakamis E, Chouvarda I, Pierscionek B, Weiler N, Wouters EF, Raptopoulos A, Nabhani-Gebara S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2831-2838 Published Date: 14 November 2016

ORIGINAL RESEARCH

Telemonitoring of home exercise cycle training in patients with COPD Franke KJ, Domanski U, Schroeder M, Jansen V, Artmann F, Weber U, Ettler R, Nilius G International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2821-2829 Published Date: 11 November 2016

ORIGINAL RESEARCH

Association between hemoglobin and prognosis in patients admitted to hospital for COPD Toft-Petersen AP, Torp-Pedersen C, Weinreich UM, Rasmussen BS International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2813-2820 Published Date: 10 November 2016

ORIGINAL RESEARCH

Persistent disabling breathlessness in chronic obstructive pulmonary disease Sundh J, Ekström M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2805-2812 Published Date: 9 November 2016

ORIGINAL RESEARCH

Combination therapy of inhaled steroids and long-acting beta2-agonists in asthma–COPD overlap syndrome Lee SY, Park HY, Kim EK, Lim SY, Rhee CK, Hwang YI, Oh YM, Lee SD, Park YB International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2797-2803 Published Date: 8 November 2016

ORIGINAL RESEARCH

Pulmonary complications after abdominal surgery in patients with mild-to-moderate chronic obstructive pulmonary disease Kim TH, Lee JS, Lee SW, Oh YM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2785-2796 Published Date: 9 November 2016

ORIGINAL RESEARCH

The association between inhaled corticosteroid and pneumonia in COPD patients: the improvement of patients’ life quality with COPD in Taiwan (IMPACT) study Wang CY, Lai CC, Yang WC, Lin CC, Chen L, Wang HC, Yu CJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2775-2783 Published Date: 8 November 2016

ORIGINAL RESEARCH

Curcumin modulates the effect of histone modification on the expression of chemokines by type II alveolar epithelial cells in a rat COPD model Gan L, Li C, Wang J, Guo X International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2765-2773 Published Date: 7 November 2016

ORIGINAL RESEARCH

Effects of long-term bronchodilators in bronchiectasis patients with airflow limitation based on bronchodilator response at baseline Jeong HJ, Lee H, Carriere KC, Kim JH, Han JH, Shin B, Jeong BH, Koh WJ, Kwon OJ, Park HY International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2757-2764 Published Date: 7 November 2016

ORIGINAL RESEARCH

Comparative analysis of budesonide/formoterol and fluticasone/salmeterol combinations in COPD patients: findings from a real-world analysis in an Italian setting Perrone V, Sangiorgi D, Buda S, Degli Esposti L International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2749-2755 Published Date: 4 November 2016

ORIGINAL RESEARCH

Sputum microbiology predicts health status in COPD Braeken DCW, Houben-Wilke S, Smid DE, Rohde GGU, Drijkoningen J JC, Wouters EFM, Spruit MA, Franssen FME International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2741-2748 Published Date: 7 November 2016

ORIGINAL RESEARCH

Platelet–lymphocyte ratios: a potential marker for pulmonary tuberculosis diagnosis in COPD patients Chen G, Wu C, Luo Z, Teng Y, Mao S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2737-2740 Published Date: 3 November 2016

ORIGINAL RESEARCH

Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD Hu G, Wu Y, Zhou Y, Wu Z, Wei L, Li Y, Peng G, Liang W, Ran P International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2729-2736 Published Date: 31 October 2016

ORIGINAL RESEARCH

Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012 Park HJ, Byun MK, Kim HJ, Kim JY, Kim YI, Yoo KH, Chun EM, Jung JY, Lee SH, Ahn CM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2721-2728 Published Date: 31 October 2016

ORIGINAL RESEARCH

The effect of conjugated linoleic acid supplementation on the nutritional status of COPD patients Ghobadi H, Matin S, Nemati A, Naghizadeh-baghi A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2711-2720 Published Date: 31 October 2016

ORIGINAL RESEARCH

Efficacy and safety of tiotropium + olodaterol maintenance treatment in patients with COPD in the TONADO® and OTEMTO® studies: a subgroup analysis by age Ferguson GT, Karpel JP, Clerisme-Beaty E, Grönke L, Voß F, Buhl R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2701-2710 Published Date: 31 October 2016

ORIGINAL RESEARCH

Effects of aerobic training combined with respiratory muscle stretching on the functional exercise capacity and thoracoabdominal kinematics in patients with COPD: a randomized and controlled trial Wada JT, Borges-Santos E, Porras DC, Paisani DM, Cukier A, Lunardi AC, Carvalho CRF International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2691-2700 Published Date: 28 October 2016

ORIGINAL RESEARCH

Management of COPD, equal treatment across age, gender, and social situation? A register study Henoch I, Strang S, Löfdahl C, Ekberg-Jansson A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2681-2690 Published Date: 26 October 2016

ORIGINAL RESEARCH

Survival after pulmonary rehabilitation in patients with COPD: impact of functional exercise capacity and its changes Camillo CA, Langer D, Osadnik CR, Pancini L, Demeyer H, Burtin C, Gosselink R, Decramer M, Janssens W, Troosters T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2671-2679 Published Date: 26 October 2016

ORIGINAL RESEARCH

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study Iepsen UW, Munch GDW, Rugbjerg M, Rinnov AR, Zacho M, Mortensen SP, Secher NH, Ringbaek T, Pedersen BK, Hellsten Y, Lange P, Thaning P International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2659-2669 Published Date: 27 October 2016

ORIGINAL RESEARCH

Prescription of opioids for breathlessness in end-stage COPD: a national population-based study Ahmadi Z, Bernelid E, Currow DC, Ekström M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2651-2657 Published Date: 21 October 2016

ORIGINAL RESEARCH

Childhood maltreatment as a risk factor for COPD: findings from a population-based survey of Canadian adults Shields ME, Hovdestad WE, Gilbert CP, Tonmyr LE International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2641-2650 Published Date: 26 October 2016

ORIGINAL RESEARCH

C-reactive protein in outpatients with acute exacerbation of COPD: its relationship with microbial etiology and severity Gallego M, Pomares X, Capilla S, Marcos MA, Suárez D, Monsó E, Montón C International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2633-2640 Published Date: 21 October 2016

ORIGINAL RESEARCH

Costs of chronic obstructive pulmonary disease in urban areas of China: a cross-sectional study in four cities Chen XY, Wang N, Chen Y, Xiao T, Fu CW, Xu B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2625-2632 Published Date: 19 October 2016

ORIGINAL RESEARCH

New evidence of increased risk of rhinitis in subjects with COPD: a longitudinal population study Bergqvist J, Andersson A, Olin AC, Murgia N, Schiöler L, Bove M, Hellgren J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2617-2623 Published Date: 19 October 2016

ORIGINAL RESEARCH

Is the 1-minute sit-to-stand test a good tool for the evaluation of the impact of pulmonary rehabilitation? Determination of the minimal important difference in COPD Vaidya T, de Bisschop C, Beaumont M, Ouksel H, Jean V, Dessables F, Chambellan A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2609-2616 Published Date: 19 October 2016

ORIGINAL RESEARCH

The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis Zhu M, Wang T, Wang C, Ji Y International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2597-2607 Published Date: 19 October 2016

REVIEW

A review of nebulized drug delivery in COPD Tashkin DP International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2585-2596 Published Date: 18 October 2016

ORIGINAL RESEARCH

Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals Unfried K, Krämer U, Sydlik U, Autengruber A, Bilstein A, Stolz S, Marini A, Schikowski T, Keymel S, Krutmann J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2573-2583 Published Date: 18 October 2016

ORIGINAL RESEARCH

TRPM8 genetic variations associated with COPD risk in the Chinese Han population Xiong M, Wang J, Guo M, Zhou Q, Lu W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2563-2571 Published Date: 14 October 2016

ORIGINAL RESEARCH

Chronotropic incompetence can limit exercise tolerance in COPD patients with lung hyperinflation Hulo S, Inamo J, Dehon A, Le Rouzic O, Edme JL, Neviere R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2553-2561 Published Date: 17 October 2016

ORIGINAL RESEARCH

Efficacy and safety of indacaterol/glycopyrronium in Japanese patients with COPD: a subgroup analysis from the SHINE study Hashimoto S, Ikeuchi H, Murata S, Kitawaki T, Ikeda K, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2543-2551 Published Date: 11 October 2016

ORIGINAL RESEARCH

Application of a diagnostic algorithm for the rare deficient variant Mmalton of alpha-1-antitrypsin deficiency: a new approach Belmonte I, Barrecheguren M, López-Martínez RM, Esquinas C, Rodríguez E, Miravitlles M, Rodríguez-Frias F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2535-2541 Published Date: 11 October 2016

ORIGINAL RESEARCH

Hand grip strength is associated with forced expiratory volume in 1 second among subjects with COPD: report from a population-based cohort study Strandkvist VJ, Backman H, Röding J, Stridsman C, Lindberg A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2527-2534 Published Date: 7 October 2016

ORIGINAL RESEARCH

Early COPD patients with lung hyperinflation associated with poorer lung function but better bronchodilator responsiveness Chen C, Jian W, Gao Y, Xie Y, Song Y, Zheng J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2519-2526 Published Date: 6 October 2016

ORIGINAL RESEARCH

Influence of inhaler technique on asthma and COPD control: a multicenter experience Dudvarski Ilic A, Zugic V, Zvezdin B, Kopitovic I, Cekerevac I, Cupurdija V, Perhoc N, Veljkovic V, Barac A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2509-2517 Published Date: 6 October 2016

ORIGINAL RESEARCH

Socioeconomic status and COPD among low- and middle-income countries Grigsby M, Siddharthan T, Chowdhury MAH, Siddiquee A, Rubinstein A, Sobrino E, Miranda JJ, Bernabe-Ortiz A, Alam D, Checkley W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2497-2507 Published Date: 5 October 2016

REVIEW

Defining and targeting health disparities in chronic obstructive pulmonary disease Pleasants RA, Riley IL, Mannino DM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2475-2496 Published Date: 4 October 2016

ORIGINAL RESEARCH

Comparison of the clinical characteristics and treatment outcomes of patients requiring hospital admission to treat eosinophilic and neutrophilic exacerbations of COPD Kang HS, Rhee CK, Kim SK, Kim JW, Lee SH, Yoon HK, Ahn JH, Kim YH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2467-2473 Published Date: 3 October 2016

ORIGINAL RESEARCH

Characterization of sputum biomarkers for asthma–COPD overlap syndrome Gao J, Iwamoto H, Koskela J, Alenius H, Hattori N, Kohno N, Laitinen T, Mazur W, Pulkkinen V International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2457-2465 Published Date: 30 September 2016

ORIGINAL RESEARCH

Image-enhanced bronchoscopic evaluation of bronchial mucosal microvasculature in COPD Fathy EM, Shafiek H, Morsi TS, El Sabaa B, Elnekidy A, Elhoffy M, Atta MS International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2447-2455 Published Date: 29 September 2016

ORIGINAL RESEARCH

Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease Gulcev M, Reilly C, Griffin TJ, Broeckling CD, Sandri BJ, Witthuhn BA, Hodgson SW, Woodruff PG, Wendt CH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2435-2446 Published Date: 29 September 2016

ORIGINAL RESEARCH

An in silico analysis of oxygen uptake of a mild COPD patient during rest and exercise using a portable oxygen concentrator Katz I, Pichelin M, Montesantos S, Kang MY, Sapoval B, Zhu K, Thevenin CP, McCoy R, Martin AR, Caillibotte G International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2427-2434 Published Date: 29 September 2016

ORIGINAL RESEARCH

Evaluation of body composition in COPD patients using multifrequency bioelectrical impedance analysis de Blasio F, de Blasio F, Miracco Berlingieri G, Bianco A, La Greca M, Franssen FME, Scalfi L International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2419-2426 Published Date: 30 September 2016

ORIGINAL RESEARCH

Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants Pomerenke A, Lea SR, Herrick S, Lindsay MA, Singh D International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2409-2417 Published Date: 29 September 2016

ORIGINAL RESEARCH

The influence of frailty syndrome on acceptance of illness in elderly patients with chronic obstructive pulmonary disease Uchmanowicz I, Jankowska-Polanska B, Chabowski M, Uchmanowicz B, Fal AM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2401-2407 Published Date: 29 September 2016

ORIGINAL RESEARCH

Prevalence of undiagnosed airflow obstruction among people with a history of smoking in a primary care setting Fu SN, Yu WC, Wong CKH, Lam MCH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2391-2399 Published Date: 27 September 2016

ORIGINAL RESEARCH

Importance of fractional exhaled nitric oxide in the differentiation of asthma–COPD overlap syndrome, asthma, and COPD Chen FJ, Huang XY, Liu YL, Lin GP, Xie CM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2385-2390 Published Date: 26 September 2016

COMMENTARY

Can resistive breathing injure the lung? Implications for COPD exacerbations Vassilakopoulos T, Toumpanakis D International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2377-2384 Published Date: 26 September 2016

ORIGINAL RESEARCH

Elevated circulating PAI-1 levels are related to lung function decline, systemic inflammation, and small airway obstruction in chronic obstructive pulmonary disease Wang H, Yang T, Li D, Wu Y, Zhang X, Pang C, Zhang J, Ying B, Wang T, Wen F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2369-2376 Published Date: 26 September 2016

ORIGINAL RESEARCH

Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD Soltani A, Walters EH, Reid DW, Shukla SD, Nowrin K, Ward C, Muller HK, Sohal SS International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2359-2367 Published Date: 22 September 2016

ORIGINAL RESEARCH

Impaired training-induced adaptation of blood pressure in COPD patients: implication of the muscle capillary bed Gouzi F, Maury J, Bughin F, Blaquière M, Ayoub B, Mercier J, Perez-Martin A, Pomiès P, Hayot M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2349-2357 Published Date: 22 September 2016

ORIGINAL RESEARCH

Effectiveness using higher inhaled corticosteroid dosage in patients with COPD by different blood eosinophilic counts Cheng SL, Lin CH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2341-2348 Published Date: 21 September 2016

ORIGINAL RESEARCH

Mortality associated with bone fractures in COPD patients Yamauchi Y, Yasunaga H, Sakamoto Y, Hasegawa W, Takeshima H, Urushiyama H, Jo T, Matsui H, Fushimi K, Nagase T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2335-2340 Published Date: 21 September 2016

ORIGINAL RESEARCH

Increased mortality in patients with severe COPD associated with high-intensity exercise: a preliminary cohort study Schaadt L, Christensen R, Kristensen LE, Henriksen M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2329-2334 Published Date: 26 September 2016

ORIGINAL RESEARCH

Chronic Pseudomonas aeruginosa infection-induced chronic bronchitis and emphysematous changes in CCSP-deficient mice Matsumoto T, Fujita M, Hirano R, Uchino J, Tajiri Y, Fukuyama S, Morimoto Y, Watanabe K International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2321-2327 Published Date: 20 September 2016

ORIGINAL RESEARCH

Preference for different relaxation techniques by COPD patients: comparison between six techniques Hyland ME, Halpin DMG, Blake S, Seamark C, Pinnuck M, Ward D, Whalley B, Greaves CJ, Hawkins AL, Seamark D International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2315-2319 Published Date: 19 September 2016

ORIGINAL RESEARCH

Influence of country-level differences on COPD prevalence Aaron SD, Gershon AS, Gao Y, Yang J, Whitmore GA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2305-2313 Published Date: 19 September 2016

REVIEW

What else should we know about experiencing COPD? A narrative review in search of patients’ psychological burden alleviation Rzadkiewicz M, Bråtas O, Espnes GA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2295-2304 Published Date: 16 September 2016

ORIGINAL RESEARCH

Breakdown of lung framework and an increase in pores of Kohn as initial events of emphysema and a cause of reduction in diffusing capacity Yoshikawa A, Sato S, Tanaka T, Hashisako M, Kashima Y, Tsuchiya T, Yamasaki N, Nagayasu T, Yamamoto H, Fukuoka J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2287-2294 Published Date: 16 September 2016

ORIGINAL RESEARCH

The effect of domiciliary noninvasive ventilation on clinical outcomes in stable and recently hospitalized patients with COPD: a systematic review and meta-analysis Dretzke J, Moore D, Dave C, Mukherjee R, Price MJ, Bayliss S, Wu X, Jordan RE, Turner AM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2269-2286 Published Date: 16 September 2016

ORIGINAL RESEARCH

Myocardial performance index correlates with the BODE index and affects quality of life in COPD patients Tannus-Silva DG, Masson-Silva JB, Ribeiro LS, Conde MB, Rabahi MF International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2261-2268 Published Date: 16 September 2016

LETTER

The use of high-flow nasal oxygen in COPD patients Silva Santos P, Esquinas AM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2259-2260 Published Date: 16 September 2016

ORIGINAL RESEARCH

Interleukin-16-producing NK cells and T-cells in the blood of tobacco smokers with and without COPD Andersson A, Malmhäll C, Houltz B, Tengvall S, Sjöstrand M, Qvarfordt I, Lindén A, Bossios A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2245-2258 Published Date: 15 September 2016

ORIGINAL RESEARCH

Systolic time intervals combined with Valsalva maneuver for the diagnosis of left ventricular dysfunction in COPD exacerbations Boubaker H, Grissa MH, Beltaief K, Dridi Z, Najjar MF, Bouida W, Boukef R, Marghli S, Nouira S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2237-2243 Published Date: 15 September 2016

ORIGINAL RESEARCH

Prevalence of comorbidities according to predominant phenotype and severity of chronic obstructive pulmonary disease Camiciottoli G, Bigazzi F, Magni C, Bonti V, Diciotti S, Bartolucci M, Mascalchi M, Pistolesi M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2229-2236 Published Date: 14 September 2016

ORIGINAL RESEARCH

Correlates of disease-specific knowledge in Chinese patients with COPD Wong CKH, Yu WC International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2221-2227 Published Date: 14 September 2016

ORIGINAL RESEARCH

Health-related quality of life in current smokers with COPD: factors associated with current smoking and new insights into sex differences Cheruvu VK, Odhiambo LA, Mowls DS, Zullo MD, Gudina AT International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2211-2219 Published Date: 15 September 2016

LETTER

Noninvasive mechanical ventilation on the ward for severe COPD: still unresolved question of balance among safety and drawbacks? Petroianni A, Esquinas AM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2209-2210 Published Date: 19 September 2016

ORIGINAL RESEARCH

Differences in physical activity according to mMRC grade in patients with COPD Hayata A, Minakata Y, Matsunaga K, Nakanishi M, Yamamoto N International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2203-2208 Published Date: 13 September 2016

ORIGINAL RESEARCH

Cost-effectiveness and budget impact of the fixed-dose dual bronchodilator combination tiotropium–olodaterol for patients with COPD in the Netherlands van Boven JF, Kocks JWH, Postma MJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2191-2201 Published Date: 19 September 2016

ORIGINAL RESEARCH

The disease burden of chronic obstructive pulmonary disease in Greece Kourlaba G, Hillas G, Vassilakopoulos T, Maniadakis N International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2179-2189 Published Date: 9 September 2016

ORIGINAL RESEARCH

Scabies increased the risk and severity of COPD: a nationwide population-based study Chen JY, Liu JM, Chang FW, Chang H, Cheng KC, Yeh CL, Wei YF, Hsu RJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2171-2178 Published Date: 9 September 2016

LETTER

Lost in interpretation: should the highest VC value be used to calculate the FEV1/VC ratio? Fortis S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2167-2170 Published Date: 9 September 2016

ORIGINAL RESEARCH

The association of renin–angiotensin system blockades and pneumonia requiring admission in patients with COPD Kim J, Lee JK, Heo EY, Chung HS, Kim DK International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2159-2166 Published Date: 9 September 2016

LETTER

Static lung volume should be used to confirm restrictive lung disease Rasam SA, Vanjare NV International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2157-2158 Published Date: 8 September 2016

ORIGINAL RESEARCH

Fractional exhaled nitric oxide levels in asthma–COPD overlap syndrome: analysis of the National Health and Nutrition Examination Survey, 2007–2012 Goto T, Camargo CA Jr, Hasegawa K International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2149-2155 Published Date: 7 September 2016

ORIGINAL RESEARCH

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls Lea SR, Metcalfe HJ, Plumb J, Beerli C, Poll C, Singh D, Abbott-Banner KH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2139-2147 Published Date: 6 September 2016

ORIGINAL RESEARCH

Application of the homology method for quantification of low-attenuation lung region in patients with and without COPD Nishio M, Nakane K, Tanaka Y International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2125-2137 Published Date: 6 September 2016

ORIGINAL RESEARCH

Inflammatory biomarkers in asthma-COPD overlap syndrome Kobayashi S, Hanagama M, Yamanda S, Ishida M, Yanai M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2117-2123 Published Date: 7 September 2016

ORIGINAL RESEARCH

Impact of tobacco smoking on cytokine signaling via interleukin-17A in the peripheral airways Levänen B, Glader P, Dahlén B, Billing B, Qvarfordt I, Palmberg L, Larsson K, Lindén A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2109-2116 Published Date: 6 September 2016

ORIGINAL RESEARCH

Incidence of utilization- and symptom-defined COPD exacerbations in hospital- and populationrecruited patients Erdal M, Johannessen A, Eagan TM, Bakke P, Gulsvik A, Grønseth R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2099-2108 Published Date: 2 September 2016

ORIGINAL RESEARCH

Impact of current cough on health-related quality of life in patients with COPD Deslee G, Burgel PR, Escamilla R, Chanez P, Court-Fortune I, Nesme-Meyer P, Brinchault-Rabin G, Perez T, Jebrak G, Caillaud D, Paillasseur JL, Roche N International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2091-2097 Published Date: 13 September 2016

ORIGINAL RESEARCH

Invasive coronary angiography in patients with acute exacerbated COPD and elevated plasma troponin Pizarro C, Herweg-Steffens N, Buchenroth M, Schulte W, Schaefer C, Hammerstingl C, Werner N, Nickenig G, Skowasch D International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2081-2089 Published Date: 16 September 2016

ORIGINAL RESEARCH

Mid-arm and calf circumferences are stronger mortality predictors than body mass index for patients with chronic obstructive pulmonary disease Ho SC, Wang JY, Kuo HP, Huang CD, Lee KY, Chuang HC, Feng PH, Chen TT, Hsu MF International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2075-2080 Published Date: 31 August 2016

ORIGINAL RESEARCH

Do self-management interventions in COPD patients work and which patients benefit most? An individual patient data meta-analysis Jonkman NH, Westland H, Trappenburg JCA, Groenwold RHH, Bischoff EW, Bourbeau J, Bucknall CE, Coultas D, Effing TW, Epton MJ, Gallefoss F, Garcia-Aymerich J, Lloyd SM, Monninkhof EM, Nguyen HQ, van der Palen J, Rice KL, Sedeno M, Taylor SJC, Troosters T, Zwar NA, Hoes AW, Schuurmans MJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2063-2074 Published Date: 31 August 2016

ORIGINAL RESEARCH

Association between Helicobacter pylori seropositivity and mild to moderate COPD: clinical implications in an Asian country with a high prevalence of H. pylori Lee HY, Kim JW, Lee JK, Heo EY, Chung HS, Kim DK International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2055-2062 Published Date: 31 August 2016

ORIGINAL RESEARCH

The efficacy of aclidinium/formoterol on lung function and symptoms in patients with COPD categorized by symptom status: a pooled analysis Miravitlles M, Chapman KR, Chuecos F, Ribera A, Garcia Gil E International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2041-2053 Published Date: 29 August 2016

ORIGINAL RESEARCH

Bronchodilator reversibility in patients with COPD revisited: short-term reproducibility Pascoe S, Wu W, Zhu CQ, Singh D International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2035-2040 Published Date: 29 August 2016

ORIGINAL RESEARCH

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2029-2034 Published Date: 26 August 2016

ORIGINAL RESEARCH

The efficacy and safety of combined tiotropium and olodaterol via the Respimat® inhaler in patients with COPD: results from the Japanese sub-population of the Tonado® studies Ichinose M, Taniguchi H, Takizawa A, Grönke L, Loaiza L, Voß F, Zhao Y, Fukuchi Y International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2017-2027 Published Date: 29 August 2016

ORIGINAL RESEARCH

The objective evaluation of obstructive pulmonary diseases with spirometry Ozkaya S, Dirican A, Tuna T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2009-2015 Published Date: 25 August 2016

ORIGINAL RESEARCH

Illness perceptions and coping determine quality of life in COPD patients Tiemensma J, Gaab E, Voorhaar M, Asijee G, Kaptein AA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:2001-2007 Published Date: 25 August 2016

ORIGINAL RESEARCH

A randomized controlled trial of telephone-mentoring with home-based walking preceding rehabilitation in COPD Cameron-Tucker HL, Wood-Baker R, Joseph L, Walters JA, Schüz N, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1991-2000 Published Date: 25 August 2016

ORIGINAL RESEARCH

Automated oxygen titration and weaning with FreeO2 in patients with acute exacerbation of COPD: a pilot randomized trial Lellouche F, Bouchard PA, Roberge M, Simard S, L’Her E, Maltais F, Lacasse Y International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1983-1990 Published Date: 24 August 2016

ORIGINAL RESEARCH

Daily home-based spirometry during withdrawal of inhaled corticosteroid in severe to very severe chronic obstructive pulmonary disease Rodriguez-Roisin R, Tetzlaff K, Watz H, Wouters EF, Disse B, Finnigan H, Magnussen H, Calverley PM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1973-1981 Published Date: 22 August 2016

ORIGINAL RESEARCH

Small pulmonary vascular alteration and acute exacerbations of COPD: quantitative computed tomography analysis Wang Z, Chen X, Liu K, Xie W, Wang H, Wei Y, Tang L, Zhu Y International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1965-1971 Published Date: 22 August 2016

ORIGINAL RESEARCH

Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population Chung KS, Jung JY, Park MS, Kim YS, Kim SK, Chang J, Song JH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1957-1963 Published Date: 19 August 2016

HYPOTHESIS

Manual evaluation of the diaphragm muscle Bordoni B, Marelli F, Morabito B, Sacconi B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1949-1956 Published Date: 18 August 2016

ORIGINAL RESEARCH

Efficacy of a self-management plan in exacerbations for patients with advanced COPD Sánchez-Nieto JM, Andújar-Espinosa R, Bernabeu-Mora R, Hu C, Gálvez-Martínez B, Carrillo-Alcaraz A, ÁlvarezMiranda CF, Meca-Birlanga O, Abad-Corpa E International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1939-1947 Published Date: 17 August 2016

ORIGINAL RESEARCH

General practitioners’ perceptions of COPD treatment: thematic analysis of qualitative interviews Molin KR, Egerod I, Valentiner LS, Lange P, Langberg H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1929-1937 Published Date: 17 August 2016

METHODOLOGY

Effects of roflumilast in COPD patients receiving inhaled corticosteroid/long-acting 2-agonist fixed-dose combination: RE2SPOND rationale and study design Rennard SI, Martinez FJ, Rabe KF, Sethi S, Pizzichini E, McIvor A, Siddiqui S, Anzueto A, Zhu H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1921-1928 Published Date: 17 August 2016

ORIGINAL RESEARCH

Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study Dharmage SC, Perret JL, Burgess JA, Lodge CJ, Johns DP, Thomas PS, Giles GG, Hopper JL, Abramson MJ, Walters EH, Matheson MC International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1911-1920 Published Date: 16 August 2016

ORIGINAL RESEARCH

Comparison of the COPD Population Screener and International Primary Care Airway Group questionnaires in a general Japanese population: the Hisayama study Tsukuya G, Samukawa T, Matsumoto K, Fukuyama S, Kumamoto T, Uchida A, Koriyama C, Ninomiya T, Inoue H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1903-1909 Published Date: 16 August 2016

ORIGINAL RESEARCH

Obesity might be a good prognosis factor for COPD patients using domiciliary noninvasive mechanical ventilation Altinoz H, Adiguzel N, Salturk C, Gungor G, Mocin O, Berk Takir H, Kargin F, Balci M, Dikensoy O, Karakurt Z International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1895-1901 Published Date: 19 August 2016

ORIGINAL RESEARCH

What is the impact of different spirometric criteria on the prevalence of spirometrically defined COPD and its comorbidities? Results from the population-based KORA study Karrasch S, Brüske I, Smith MP, Thorand B, Huth C, Ladwig KH, Kronenberg F, Heinrich J, Holle R, Peters A, Schulz H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1881-1894 Published Date: 16 August 2016

ORIGINAL RESEARCH

Correct usage, ease of use, and preference of two dry powder inhalers in patients with COPD: analysis of five phase III, randomized trials Riley JH, Tabberer M, Richard N, Donald A, Church A, Harris SS International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1873-1880 Published Date: 12 August 2016

ORIGINAL RESEARCH

Community-acquired pneumonia and survival of critically ill acute exacerbation of COPD patients in respiratory intensive care units Lu ZW, Cheng YS, Tu XW, Chen L, Chen H, Yang J, Wang JY, Zhang LQ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1867-1872 Published Date: 9 August 2016

ORIGINAL RESEARCH

Comorbidity as a contributor to frequent severe acute exacerbation in COPD patients Jeong SH, Lee H, Carriere KC, Shin SH, Moon SM, Jeong BH, Koh WJ, Park HY International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1857-1865 Published Date: 4 August 2016

ORIGINAL RESEARCH

Assessment of satisfaction with different dry powder inhalation devices in Greek patients with COPD and asthma: the ANASA study Zervas E, Samitas K, Gaga M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1845-1855 Published Date: 5 August 2016

LETTER

The Barthel index-dyspnea: a new two-dimensional dyspnea scale Chuang ML International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1843-1844 Published Date: 3 August 2016

ORIGINAL RESEARCH

A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters Hwang J, Lee M, Lee SM, Oh SY, Oh YM, Kim N, Seo JB International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1835-1841 Published Date: 3 August 2016

ORIGINAL RESEARCH

Speckle tracking echocardiography in chronic obstructive pulmonary disease and overlapping obstructive sleep apnea Pizarro C, van Essen F, Linnhoff F, Schueler R, Hammerstingl C, Nickenig G, Skowasch D, Weber M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1823-1834 Published Date: 3 August 2016

ORIGINAL RESEARCH

Assessing the effect of culturally specific audiovisual educational interventions on attaining selfmanagement skills for chronic obstructive pulmonary disease in Mandarin- and Cantonesespeaking patients: a randomized controlled trial Poureslami I, Kwan S, Lam S, Khan NA, FitzGerald JM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1811-1822 Published Date: 3 August 2016

ORIGINAL RESEARCH

Distinct symptom experiences in subgroups of patients with COPD Christensen VL, Rustøen T, Cooper BA, Miaskowski C, Henriksen AH, Bentsen SB, Holm AM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1801-1809 Published Date: 2 August 2016

ORIGINAL RESEARCH

Low cost biological lung volume reduction therapy for advanced emphysema Bakeer M, Abdelgawad TT, El-Metwaly R, El-Morsi A, El-Badrawy MK, El-Sharawy S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1793-1800 Published Date: 3 August 2016

ORIGINAL RESEARCH

A simple and rapid test of physical performance in chronic obstructive pulmonary disease Albarrati AM, Gale NS, Enright S, Munnery MM, Cockcroft JR, Shale DJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1785-1791 Published Date: 2 August 2016

ORIGINAL RESEARCH

Impact of anemia on short-term survival in severe COPD exacerbations: a cohort study Ergan B, Ergün R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1775-1783 Published Date: 1 August 2016

ORIGINAL RESEARCH

Predictors of pneumothorax following endoscopic valve therapy in patients with severe emphysema Gompelmann D, Lim H, Eberhardt R, Gerovasili V, Herth FJF, Heussel CP, Eichinger M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1767-1773 Published Date: 1 August 2016

ORIGINAL RESEARCH

Determinants of activation for self-management in patients with COPD Korpershoek YJG, Bos-Touwen ID, de Man-van Ginkel JM, Lammers JWJ, Schuurmans MJ, Trappenburg JCA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1757-1766 Published Date: 1 August 2016

ORIGINAL RESEARCH

Individualized lung function trends in alpha-1-antitrypsin deficiency: a need for patience in order to provide patient centered management? Stockley RA, Edgar RG, Pillai A, Turner AM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1745-1756 Published Date: 1 August 2016

ORIGINAL RESEARCH

Nrf2 expression is increased in peripheral blood mononuclear cells derived from mild–moderate ex-smoker COPD patients with persistent oxidative stress Fratta Pasini AM, Ferrari M, Stranieri C, Vallerio P, Mozzini C, Garbin U, Zambon G, Cominacini L International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1733-1743 Published Date: 28 July 2016

ORIGINAL RESEARCH

The inhibitory mechanism of Cordyceps sinensis on cigarette smoke extract-induced senescence in human bronchial epithelial cells Liu AL, Wu JX, Li AJ, Bi WX, Liu T, Cao LZ, Liu YH, Dong L International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1721-1731 Published Date: 28 July 2016

ORIGINAL RESEARCH

Alteration of spontaneous brain activity in COPD patients Zhang J, Chen J, Yu Q, Fan C, Zhang R, Lin J, Yang T, Fan M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1713-1719 Published Date: 28 July 2016

ORIGINAL RESEARCH

Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice Fujita M, Ouchi H, Ikegame S, Harada E, Matsumoto T, Uchino J, Nakanishi Y, Watanabe K International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1705-1712 Published Date: 28 July 2016

ORIGINAL RESEARCH

Impact of lung function on exacerbations, health care utilization, and costs among patients with COPD Ke X, Marvel J, Yu TC, Wertz D, Geremakis C, Wang L, Stephenson JJ, Mannino DM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1689-1703 Published Date: 27 July 2016

ORIGINAL RESEARCH

Quality of life and adherence to inhaled corticosteroids and tiotropium in COPD are related Koehorst-ter Huurne K, Kort S, van der Palen J, van Beurden WJC, Movig KLL, van der Valk P, Brusse-Keizer M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1679-1688 Published Date: 26 July 2016

ORIGINAL RESEARCH

Respiratory muscle strength effect on linear and nonlinear heart rate variability parameters in COPD patients Goulart CL, Simon JC, Schneiders PB, San Martin EA, Cabiddu R, Borghi-Silva A, Trimer R, da Silva ALG International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1671-1677 Published Date: 26 July 2016

ORIGINAL RESEARCH

Cause-specific mortality in individuals with severe alpha 1-antitrypsin deficiency in comparison with the general population in Sweden Tanash HA, Ekström M, Wagner P, Piitulainen E International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1663-1669 Published Date: 26 July 2016

ORIGINAL RESEARCH

Sex differences of COPD phenotypes in nonsmoking patients Hong Y, Ji W, An S, Han SS, Lee SJ, Kim WJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1657-1662 Published Date: 22 July 2016

ORIGINAL RESEARCH

An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke Shukla SD, Fairbairn RL, Gell DA, Latham RD, Sohal SS, Walters EH, O’Toole RF International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1647-1655 Published Date: 25 July 2016

ORIGINAL RESEARCH

A year in the life of German patients with COPD: the DACCORD observational study Buhl R, Criée CP, Kardos P, Vogelmeier C, Lossi N, Mailänder C, Worth H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1639-1646 Published Date: 20 July 2016

ORIGINAL RESEARCH

The differential effects of inspiratory, expiratory, and combined resistive breathing on healthy lung Loverdos K, Toumpanakis D, Litsiou E, Karavana V, Glynos C, Magkou C, Theocharis S, Vassilakopoulos T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1623-1638 Published Date: 19 July 2016

ORIGINAL RESEARCH

Effects of biomass smoke on pulmonary functions: a case control study Balcan B, Akan S, Ugurlu AO, Handemir BO, Ceyhan BB, Ozkaya S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1615-1622 Published Date: 19 July 2016

ORIGINAL RESEARCH

Inhaled corticosteroids can reduce osteoporosis in female patients with COPD Liu SF, Kuo HC, Liu GH, Ho SC, Chang HC, Huang HT, Chen YM, Huang KT, Chen KY, Fang WF, Lin MC International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1607-1614 Published Date: 14 July 2016

ORIGINAL RESEARCH

Phenotypic assessment of pulmonary hypertension using high-resolution echocardiography is feasible in neonatal mice with experimental bronchopulmonary dysplasia and pulmonary hypertension: a step toward preventing chronic obstructive pulmonary disease Reynolds CL, Zhang S, Shrestha AK, Barrios R, Shivanna B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1597-1605 Published Date: 14 July 2016

REVIEW

Involvement of informal caregivers in supporting patients with COPD: a review of intervention studies Bryant J, Mansfield E, Boyes AW, Waller A, Sanson-Fisher R, Regan T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1587-1596 Published Date: 14 July 2016

COMMENTARY

Acute exacerbation of COPD: is it the "stroke of the lungs"? Hillas G, Perlikos F, Tzanakis N International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1579-1586 Published Date: 13 July 2016

ORIGINAL RESEARCH

Associations of autophagy with lung diffusion capacity and oxygen saturation in severe COPD: effects of particulate air pollution Lee KY, Chiang LL, Ho SC, Liu WT, Chen TT, Feng PH, Su CL, Chuang KJ, Chang CC, Chuang HC International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1569-1578 Published Date: 11 July 2016

REVIEW

Brazilian studies on pulmonary function in COPD patients: what are the gaps? Lopes AJ, Melo PL International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1553-1567 Published Date: 11 July 2016

ORIGINAL RESEARCH

The COPD assessment test and St George's Respiratory Questionnaire: are they equivalent in subjects with COPD? Morishita-Katsu M, Nishimura K, Taniguchi H, Kimura T, Kondoh Y, Kataoka K, Ogawa T, Watanabe F, Arizono S, Nishiyama O, Nakayasu K, Imaizumi K, Hasegawa Y International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1543-1551 Published Date: 7 July 2016

CLINICAL TRIAL REPORT

Pulmonary vascular effects of pulsed inhaled nitric oxide in COPD patients with pulmonary hypertension Hajian B, De Backer J, Vos W, Van Holsbeke C, Ferreira F, Quinn DA, Hufkens A, Claes R, De Backer W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1533-1541 Published Date: 5 July 2016

ORIGINAL RESEARCH

Smoking-related interstitial fibrosis combined with pulmonary emphysema: computed tomography-pathologic correlative study using lobectomy specimens Otani H, Tanaka T, Murata K, Fukuoka J, Nitta N, Nagatani Y, Sonoda A, Takahashi M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1521-1532 Published Date: 4 July 2016

ORIGINAL RESEARCH

Characteristics of elderly patients with COPD and newly diagnosed lung cancer, and factors associated with treatment decision Qin JW, Li GS, Zhou JM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1515-1520 Published Date: 4 July 2016

ORIGINAL RESEARCH

Relationship between balance and physical activity measured by an activity monitor in elderly COPD patients Iwakura M, Okura K, Shibata K, Kawagoshi A, Sugawara K, Takahashi H, Shioya T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1505-1514 Published Date: 1 July 2016

ORIGINAL RESEARCH

Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD Negewo NA, McDonald VM, Baines KJ, Wark PAB, Simpson JL, Jones PW, Gibson PG International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1495-1504 Published Date: 1 July 2016

ORIGINAL RESEARCH

Reduced sputum expression of interferon-stimulated genes in severe COPD Hilzendeger C, da Silva J, Henket M, Schleich F, Corhay JL, Kebadze T, Edwards MR, Mallia P, Johnston SL, Louis R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1485-1494 Published Date: 30 June 2016

REVIEW

Potential treatment benefits and safety of roflumilast in COPD: a systematic review and metaanalysis Yuan L, Dai X, Yang M, Cai Q, Shao N International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1477-1483 Published Date: 30 June 2016

ORIGINAL RESEARCH

Efficacy and safety of ipratropium bromide/salbutamol sulphate administered in a hydrofluoroalkane metered-dose inhaler for the treatment of COPD Bhattacharya A, Bhargava S, Singh V, Talwar D, Whig J, Rebello J, Purandare S, Gogtay J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1469-1476 Published Date: 30 June 2016

ORIGINAL RESEARCH

Pulmonary effects of active smoking and secondhand smoke exposure among adolescent students in Juárez, Mexico Bird Y, Staines-Orozco H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1459-1467 Published Date: 29 June 2016

ORIGINAL RESEARCH

A new diagnosis of asthma or COPD is linked to smoking cessation – the Tromsø study Danielsen SE, Løchen ML, Medbø A, Vold ML, Melbye H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1453-1458 Published Date: 30 June 2016

ORIGINAL RESEARCH

An international randomized study of a home-based self-management program for severe COPD: the COMET Bourbeau J, Casan P, Tognella S, Haidl P, Texereau JB, Kessler R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1447-1451 Published Date: 28 June 2016

ORIGINAL RESEARCH

Morphological changes in small pulmonary vessels are associated with severe acute exacerbation in chronic obstructive pulmonary disease Yoshimura K, Suzuki Y, Uto T, Sato J, Imokawa S, Suda T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1435-1445 Published Date: 28 June 2016

ORIGINAL RESEARCH

Early bronchodilator action of glycopyrronium versus tiotropium in moderate-to-severe COPD patients: a cross-over blinded randomized study (Symptoms and Pulmonary function in the moRnING) Marin JM, Beeh KM, Clemens A, Castellani W, Schaper L, Saralaya D, Gunstone A, Casamor R, Kostikas K, Aalamian-Mattheis M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1425-1434 Published Date: 28 June 2016

ORIGINAL RESEARCH

Prevention of clinically important deteriorations in COPD with umeclidinium/vilanterol Singh D, Maleki-Yazdi MR, Tombs L, Iqbal A, Fahy WA, Naya I International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1413-1424 Published Date: 24 June 2016

ORIGINAL RESEARCH

Effect of outpatient therapy with inhaled corticosteroids on decreasing in-hospital mortality from pneumonia in patients with COPD Yamauchi Y, Yasunaga H, Hasegawa W, Sakamoto Y, Takeshima H, Jo T, Matsui H, Fushimi K, Nagase T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1403-1411 Published Date: 23 June 2016

REVIEW

Lung inflammation caused by inhaled toxicants: a review Wong J, Magun BE, Wood LJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1391-1401 Published Date: 23 June 2016

ORIGINAL RESEARCH

Point-of-care procalcitonin test to reduce antibiotic exposure in patients hospitalized with acute exacerbation of COPD Corti C, Fally M, Fabricius-Bjerre A, Mortensen K, Jensen BN, Andreassen HF, Porsbjerg C, Knudsen JD, Jensen JU International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1381-1389 Published Date: 22 June 2016

REVIEW

Association between TNF- -308 G/A polymorphism and COPD susceptibility: a meta-analysis update Zhang L, Gu H, Gu Y, Zeng X International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1367-1379 Published Date: 22 June 2016

ORIGINAL RESEARCH

Vitamin D should be supplemented more actively in elderly patients with coronary heart disease combined with COPD Zhang L, Yuan QY International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1359-1365 Published Date: 21 June 2016

ORIGINAL RESEARCH

Immediate effect of manual therapy on respiratory functions and inspiratory muscle strength in patients with COPD Yilmaz Yelvar GD, Çirak Y, Parlak Demir Y, Dalkilinç M, Bozkurt B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1353-1357 Published Date: 20 June 2016

ORIGINAL RESEARCH

The impact of coping on the somatic and mental status of patients with COPD: a cross-sectional study Papava I, Oancea C, Enatescu VR, Bredicean AC, Dehelean L, Romosan RS, Timar B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1343-1351 Published Date: 20 June 2016

ORIGINAL RESEARCH

Chronic bronchitis is an independently associated factor for more symptom and high-risk groups Choi JY, Yoon HK, Park SJ, Park YB, Shin KC, Na JO, Yoo KH, Jung KS, Kim YK, Rhee CK International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1335-1341 Published Date: 21 June 2016

ORIGINAL RESEARCH

Factors associated with exacerbation in mild-to-moderate COPD patients Kim JK, Lee SH, Lee BH, Lee CY, Kim DJ, Min KH, Kim SK, Yoo KH, Jung KS, Hwang YI International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1327-1333 Published Date: 16 June 2016

ORIGINAL RESEARCH

Prevalence of and risk factors for postoperative pulmonary complications after lung cancer surgery in patients with early-stage COPD Kim ES, Kim YT, Kang CH, Park IK, Bae W, Choi SM, Lee J, Park YS, Lee CH, Lee SM, Yim JJ, Kim YW, Han SK, Yoo CG International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1317-1326 Published Date: 16 June 2016

ORIGINAL RESEARCH

Changes in respiratory function impairment following the treatment of severe pulmonary tuberculosis – limitations for the underlying COPD detection Radovic M, Ristic L, Ciric Z, Dinic-Radovic V, Stankovic I, Pejcic T, Rancic M, Bogdanovic D International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1307-1316 Published Date: 16 June 2016

REVIEW

The asthma–COPD overlap syndrome: do we really need another syndrome in the already complex matrix of airway disease? Kostikas K, Clemens A, Patalano F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1297-1306 Published Date: 16 June 2016

ORIGINAL RESEARCH

Depression symptoms reduce physical activity in COPD patients: a prospective multicenter study Dueñas-Espín I, Demeyer H, Gimeno-Santos E, Polkey MI, Hopkinson NS, Rabinovich RA, Dobbels F, Karlsson N, Troosters T, Garcia-Aymerich J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1287-1295 Published Date: 10 June 2016

ORIGINAL RESEARCH

1-Antitrypsin reduces rhinovirus infection in primary human airway epithelial cells exposed to cigarette smoke Berman R, Jiang D, Wu Q, Chu HW International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1279-1286 Published Date: 10 June 2016

ORIGINAL RESEARCH

Impact of mild exacerbation on COPD symptoms in a Japanese cohort Sato M, Chubachi S, Sasaki M, Haraguchi M, Kameyama N, Tsutsumi A, Takahashi S, Nakamura H, Asano K, Betsuyaku T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1269-1278 Published Date: 9 June 2016

ORIGINAL RESEARCH

Impact of combined pulmonary fibrosis and emphysema on surgical complications and long-term survival in patients undergoing surgery for non-small-cell lung cancer Hata A, Sekine Y, Kota O, Koh E, Yoshino I International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1261-1268 Published Date: 9 June 2016

ORIGINAL RESEARCH

Lung perfusion and emphysema distribution affect the outcome of endobronchial valve therapy Thomsen C, Theilig D, Herzog D, Poellinger A, Doellinger F, Schreiter N, Schreiter V, Schürmann D, TemmesfeldWollbrueck B, Hippenstiel S, Suttorp N, Hubner RH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1245-1259 Published Date: 9 June 2016

ORIGINAL RESEARCH

Efficacy and safety of twice-daily glycopyrrolate in patients with stable, symptomatic COPD with moderate-to-severe airflow limitation: the GEM1 study LaForce C, Feldman G, Spangenthal S, Eckert JH, Henley M, Patalano F, D’Andrea P International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1233-1243 Published Date: 8 June 2016

ORIGINAL RESEARCH

Prompt initiation of maintenance treatment following a COPD exacerbation: outcomes in a large insured population Coutinho AD, Lokhandwala T, Boggs RL, Dalal AA, Landsman-Blumberg PB, Priest J, Stempel DA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1223-1231 Published Date: 8 June 2016

ORIGINAL RESEARCH

Agreement between a simple dyspnea-guided treatment algorithm for stable COPD and the GOLD guidelines: a pilot study Cabrera C, Casanova C, Martín Y, Mirabal V, Sánchez MC, Álvarez F, Juliá G, Cabrera-Navarro P, García-Bello MA, Marín JM, de-Torres JP, Divo M, Celli B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1217-1222 Published Date: 8 June 2016

ORIGINAL RESEARCH

Smokers with emphysema and small airway disease on computed tomography have lower bone density Pompe E, de Jong PA, van Rikxoort EM, Gallardo Estrella L, de Jong WU, Vliegenthart R, Oudkerk M, van der Aalst CM, van Ginneken B, Lammers JWJ, Mohamed Hoesein FAA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1207-1216 Published Date: 8 June 2016

ORIGINAL RESEARCH

Development of a Barthel Index based on dyspnea for patients with respiratory diseases Vitacca M, Paneroni M, Baiardi P, De Carolis V, Zampogna E, Belli S, Carone M, Spanevello A, Balbi B, Bertolotti G International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1199-1206 Published Date: 7 June 2016

ORIGINAL RESEARCH

Home-based neuromuscular electrical stimulation improves exercise tolerance and health-related quality of life in patients with COPD Coquart JB, Grosbois JM, Olivier C, Bart F, Castres I, Wallaert B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1189-1197 Published Date: 3 June 2016

REVIEW

Action plans for COPD: strategies to manage exacerbations and improve outcomes Jalota L, Jain VV International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1179-1188 Published Date: 2 June 2016

ORIGINAL RESEARCH

Determinants for changing the treatment of COPD: a regression analysis from a clinical audit López-Campos JL, Abad Arranz M, Calero Acuña C, Romero Valero F, Ayerbe García R, Hidalgo Molina A, Aguilar Perez-Grovas RI, García Gil F, Casas Maldonado F, Caballero Ballesteros L, Sánchez Palop M, Pérez-Tejero D, Segado A, Calvo Bonachera J, Hernández Sierra B, Doménech A, Arroyo Varela M, González Vargas F, Cruz Rueda JJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1171-1178 Published Date: 2 June 2016

ORIGINAL RESEARCH

Can a supported self-management program for COPD upon hospital discharge reduce readmissions? A randomized controlled trial Johnson-Warrington V, Rees K, Gelder C, Morgan MD, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1161-1169 Published Date: 2 June 2016

ORIGINAL RESEARCH

Can patients with moderate to severe acute respiratory failure from COPD be treated safely with noninvasive mechanical ventilation on the ward? Yalcinsoy M, Salturk C, Oztas S, Gungor S, Ozmen I, Kabadayi F, Oztim AA, Aksoy E, Adıguzel N, Oruc O, Karakurt Z International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1151-1160 Published Date: 31 May 2016

ORIGINAL RESEARCH

Asthma-chronic obstructive pulmonary disease overlap syndrome in the urban Chinese population: prevalence and disease burden using the 2010, 2012, and 2013 China National Health and Wellness Surveys Ding B, DiBonaventura M, Karlsson N, Ling X International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1139-1150 Published Date: 9 June 2016

ORIGINAL RESEARCH

Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity Koo HK, Hong Y, Lim MN, Yim JJ, Kim WJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1129-1137 Published Date: 27 May 2016

ORIGINAL RESEARCH

Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration Kim KH, Park TS, Kim YS, Lee JS, Oh YM, Lee SD, Lee SW International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1119-1128 Published Date: 27 May 2016

ORIGINAL RESEARCH

Accuracy of forced oscillation technique to assess lung function in geriatric COPD population Tse HN, Tseng CZ, Wong KY, Yee KS, Ng LY International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1105-1118 Published Date: 26 May 2016

ORIGINAL RESEARCH

Symptoms and lung function decline in a middle-aged cohort of males and females in Australia Abramson MJ, Kaushik S, Benke GP, Borg BM, Smith CL, Dharmage SC, Thompson BR International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1097-1103 Published Date: 26 May 2016

ORIGINAL RESEARCH

Are interstitial lung abnormalities associated with COPD? A nested case–control study Bozzetti F, Paladini I, Rabaiotti E, Franceschini A, Alfieri V, Chetta A, Crisafulli E, Silva M, Pastorino U, Sverzellati N International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1087-1096 Published Date: 26 May 2016

ORIGINAL RESEARCH

Nasal highflow improves ventilation in patients with COPD Bräunlich J, Köhler M, Wirtz H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1077-1085 Published Date: 25 May 2016

REVIEW

Acute oxygen therapy: a review of prescribing and delivery practices Cousins JL, Wark PAB, McDonald VM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1067-1075 Published Date: 24 May 2016

ORIGINAL RESEARCH

COPD promotes migration of A549 lung cancer cells: the role of chemokine CCL21 Kuźnar-Kamińska B, Mikuła-Pietrasik J, Sosińska P, Książek K, Batura-Gabryel H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1061-1066 Published Date: 20 May 2016

ORIGINAL RESEARCH

Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study Chan MC, Lin CH, Kou YR International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1053-1059 Published Date: 18 May 2016

ORIGINAL RESEARCH

Investigating sensitivity, specificity, and area under the curve of the Clinical COPD Questionnaire, COPD Assessment Test, and Modified Medical Research Council scale according to GOLD using St George's Respiratory Questionnaire cutoff 25 (and 20) as reference Tsiligianni IG, Alma HJ, de Jong C, Jelusic D, Wittmann M, Schuler M, Schultz K, Kollen BJ, van der Molen T, Kocks JWH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1045-1052 Published Date: 18 May 2016

ORIGINAL RESEARCH

Effects of budesonide on toll-like receptor expression in alveolar macrophages from smokers with and without COPD Ji J, von Schéele I, Billing B, Dahlén B, Lantz AS, Larsson K, Palmberg L International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1035-1043 Published Date: 17 May 2016

CORRIGENDUM

Triple therapy with salmeterol/fluticasone propionate 50/250 plus tiotropium bromide improve lung function versus individual treatments in moderate-to-severe Japanese COPD patients: a randomized controlled trial – Evaluation of Airway sGaw after treatment with tripLE [Corrigendum] Saito T, Takeda A, Hashimoto K, Kobayashi A, Hayamizu T, Hagan GW International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1031-1033 Published Date: 18 May 2016

ORIGINAL RESEARCH

A comparison of synchronized intermittent mandatory ventilation and pressure-regulated volume control ventilation in elderly patients with acute exacerbations of COPD and respiratory failure Chang SC, Shi JD, Fu CP, Wu X, Li SQ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1023-1029 Published Date: 17 May 2016

ORIGINAL RESEARCH

Left ventricular structure and remodeling in patients with COPD Pelà G, Li Calzi M, Pinelli S, Andreoli R, Sverzellati N, Bertorelli G, Goldoni M, Chetta A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1015-1022 Published Date: 13 May 2016

ORIGINAL RESEARCH

Extracellular cadmium in the bronchoalveolar space of long-term tobacco smokers with and without COPD and its association with inflammation Sundblad BM, Ji J, Levänen B, Midander K, Julander A, Larsson K, Palmberg L, Lindén A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1005-1013 Published Date: 11 May 2016

ORIGINAL RESEARCH

Diagnosis of alpha-1 antitrypsin deficiency: a population-based study Barrecheguren M, Monteagudo M, Simonet P, Llor C, Rodriguez E, Ferrer J, Esquinas C, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:999-1004 Published Date: 10 May 2016

ORIGINAL RESEARCH

Comparison of pulmonary function in patients with COPD, asthma-COPD overlap syndrome, and asthma with airflow limitation Kitaguchi Y, Yasuo M, Hanaoka M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:991-997 Published Date: 9 May 2016

ORIGINAL RESEARCH

Follow-up study on management of chronic obstructive pulmonary disease in Hunan Province, the People's Republic of China Zeng YQ, Xu JX, Cai S, Jiang F, Hu AM, Liu HY, Bei CL, Chen P International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:981-989 Published Date: 10 May 2016

ORIGINAL RESEARCH

A randomized, parallel-group study to evaluate the efficacy of umeclidinium/vilanterol 62.5/25 µg on health-related quality of life in patients with COPD Siler TM, Donald AC, O’Dell D, Church A, Fahy WA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:971-979 Published Date: 9 May 2016

ORIGINAL RESEARCH

Assessment of illness acceptance by patients with COPD and the prevalence of depression and anxiety in COPD Uchmanowicz I, Jankowska-Polanska B, Motowidlo U, Uchmanowicz B, Chabowski M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:963-970 Published Date: 9 May 2016

ORIGINAL RESEARCH

Quantitative computed tomography measurements of emphysema for diagnosing asthmachronic obstructive pulmonary disease overlap syndrome Xie M, Wang W, Dou S, Cui L, Xiao W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:953-961 Published Date: 6 May 2016

CLINICAL TRIAL REPORT

A randomized clinical trial of neurally adjusted ventilatory assist versus conventional weaning mode in patients with COPD and prolonged mechanical ventilation Kuo NY, Tu ML, Hung TY, Liu SF, Chung YH, Lin MC, Wu CC International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:945-951 Published Date: 11 May 2016

ORIGINAL RESEARCH

Assisted ventilation in COPD – association between previous hospitalizations and mortality Toft-Petersen AP, Torp-Pedersen C, Weinreich UM, Rasmussen BS International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:935-943 Published Date: 3 May 2016

ORIGINAL RESEARCH

Vital capacity and COPD: the Swedish CArdioPulmonary bioImage Study (SCAPIS) Torén K, Olin AC, Lindberg A, Vikgren J, Schiöler L, Brandberg J, Johnsson Å, Engström G, Persson HL, Sköld M, Hedner J, Lindberg E, Malinovschi A, Piitulainen E, Wollmer P, Rosengren A, Janson C, Blomberg A, Bergström G International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:927-933 Published Date: 2 May 2016

ORIGINAL RESEARCH

Chronic obstructive pulmonary disease phenotypes and balance impairment Voica AS, Oancea C, Tudorache E, Crisan AF, Fira-Mladinescu O, Tudorache V, Timar B International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:919-925 Published Date: 29 April 2016

ORIGINAL RESEARCH

In vitro modeling of COPD inflammation and limitation of p38 inhibitor — SB203580 Meng AH, Zhang XP, Wu SY, Wu MX, Li J, Yan XX, Kopec-Harding K, Wu JK International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:909-917 Published Date: 29 April 2016

ORIGINAL RESEARCH

COPD disease severity and the risk of venous thromboembolic events: a matched case–control study Morgan AD, Herrett E, De Stavola BL, Smeeth L, Quint JK International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:899-908 Published Date: 28 April 2016

ORIGINAL RESEARCH

Impact of tiotropium + olodaterol on physical functioning in COPD: results of an open-label observational study Sauer R, Hänsel M, Buhl R, Rubin RA, Frey M, Glaab T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:891-898 Published Date: 27 April 2016

ORIGINAL RESEARCH

Health behaviors and their correlates among participants in the Continuing to Confront COPD International Patient Survey Müllerová H, Landis SH, Aisanov Z, Davis KJ, Ichinose M, Mannino DM, Maskell J, Menezes AM, van der Molen T, Oh YM, Tabberer M, Han MK International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:881-890 Published Date: 27 April 2016

ORIGINAL RESEARCH

Prevalence of airflow limitation in subjects undergoing comprehensive health examination in Japan: Survey of Chronic Obstructive pulmonary disease Patients Epidemiology in Japan Omori H, Kaise T, Suzuki T, Hagan G International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:873-880 Published Date: 22 April 2016

REVIEW

Impact of air quality guidelines on COPD sufferers Liu Y, Yan S, Poh K, Liu S, Iyioriobhe E, Sterling DA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:839-872 Published Date: 21 April 2016

ORIGINAL RESEARCH

Prevention of COPD exacerbation by lysozyme: a double-blind, randomized, placebo-controlled study Fukuchi Y, Tatsumi K, Inoue H, Sakata Y, Shibata K, Miyagishi H, Marukawa Y, Ichinose M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:831-838 Published Date: 21 April 2016

ORIGINAL RESEARCH

Prognostic utility of the 2011 GOLD classification and other multidimensional tools in Asian COPD patients: a prospective cohort study Chan HP, Mukhopadhyay A, Chong PLP, Chin S, Wong XY, Ong V, Chan YH, Lim TK, Phua J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:823-829 Published Date: 22 April 2016

REVIEW

Do telemedical interventions improve quality of life in patients with COPD? A systematic review Gregersen TL, Green A, Frausing E, Ringbæk T, Brøndum E, Suppli Ulrik C International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:809-822 Published Date: 21 April 2016

ORIGINAL RESEARCH

High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial Johnson K, McEvoy CE, Naqvi S, Wendt C, Reilkoff RA, Kunisaki KM, Wetherbee EE, Nelson D, Tirouvanziam R, Niewoehner DE International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:799-807 Published Date: 21 April 2016

REVIEW

Dual therapy strategies for COPD: the scientific rationale for LAMA + LABA Cohen J, Miles MC, Donohue JF, Ohar JA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:785-797 Published Date: 15 April 2016

ORIGINAL RESEARCH

Impacts of coexisting bronchial asthma on severe exacerbations in mild-to-moderate COPD: results from a national database Lee H, Rhee CK, Lee BJ, Choi DC, Kim JA, Kim SH, Jeong Y, Kim TH, Chon GR, Jung KS, Lee SH, Price D, Yoo KH, Park HY International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:775-783 Published Date: 15 April 2016

REVIEW

The fissure: interlobar collateral ventilation and implications for endoscopic therapy in emphysema Koster TD, Slebos DJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:765-773 Published Date: 13 April 2016

ORIGINAL RESEARCH

Continuous quantitative measurement of the proximal airway dimensions and lung density on four-dimensional dynamic-ventilation CT in smokers Yamashiro T, Moriya H, Tsubakimoto M, Matsuoka S, Murayama S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:755-764 Published Date: 13 April 2016

ORIGINAL RESEARCH

Effect of inhaled drugs on anxiety and depression in patients with chronic obstructive pulmonary disease: a prospective observational study Hyun MK, Lee NR, Jang EJ, Yim JJ, Lee CH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:747-754 Published Date: 11 April 2016

ORIGINAL RESEARCH

Does COPD risk vary by ethnicity? A retrospective cross-sectional study Gilkes A, Ashworth M, Schofield P, Harries TH, Durbaba S, Weston C, White P International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:739-746 Published Date: 7 April 2016

ORIGINAL RESEARCH

Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD Park YM, Kim YS, Kang YA, Shin JH, Oh YM, Seo JB, Jung JY, Lee SD International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:731-738 Published Date: 7 April 2016

ORIGINAL RESEARCH

A randomized, blinded study to evaluate the efficacy and safety of umeclidinium 62.5 µg compared with tiotropium 18 µg in patients with COPD Feldman G, Maltais F, Khindri S, Vahdati-Bolouri M, Church A, Fahy WA, Trivedi R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:719-730 Published Date: 7 April 2016

ORIGINAL RESEARCH

Effects of combined training vs aerobic training on cognitive functions in COPD: a randomized controlled trial Aquino G, Iuliano E, di Cagno A, Vardaro A, Fiorilli G, Moffa S, Di Costanzo A, De Simone G, Calcagno G International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:711-718 Published Date: 4 April 2016

ORIGINAL RESEARCH

COPD exacerbations by disease severity in England Merinopoulou E, Raluy-Callado M, Ramagopalan S, MacLachlan S, Khalid JM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:697-709 Published Date: 1 April 2016

STUDY PROTOCOL

The Belgian trial with azithromycin for acute COPD exacerbations requiring hospitalization: an investigator-initiated study protocol for a multicenter, randomized, double-blind, placebocontrolled trial Vermeersch K, Gabrovska M, Deslypere G, Demedts IK, Slabbynck H, Aumann J, Ninane V, Verleden GM, Troosters T, Bogaerts K, Brusselle GG, Janssens W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:687-696 Published Date: 31 March 2016

ORIGINAL RESEARCH

The effect of benzodiazepines on insomnia in patients with chronic obstructive pulmonary disease: a meta-analysis of treatment efficacy and safety Lu XM, Zhu JP, Zhou XM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:675-685 Published Date: 4 April 2016

ORIGINAL RESEARCH

Predictive factors warrant screening for obstructive sleep apnea in COPD: a Taiwan National Survey Hang LW, Hsu JY, Chang CJ, Wang HC, Cheng SL, Lin CH, Chan MC, Wang CC, Perng DW, Yu CJ International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:665-673 Published Date: 30 March 2016

ORIGINAL RESEARCH

Six-minute stepper test: a valid clinical exercise tolerance test for COPD patients Grosbois JM, Riquier C, Chehere B, Coquart J, Béhal H, Bart F, Wallaert B, Chenivesse C International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:657-663 Published Date: 29 March 2016

ORIGINAL RESEARCH

COPD advances in left ventricular diastolic dysfunction Kubota Y, Asai K, Murai K, Tsukada YT, Hayashi H, Saito Y, Azuma A, Gemma A, Shimizu W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:649-655 Published Date: 29 March 2016

REVIEW

COPD and osteoporosis: links, risks, and treatment challenges Inoue D, Watanabe R, Okazaki R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:637-648 Published Date: 29 March 2016

ORIGINAL RESEARCH

COPD in primary lung cancer patients: prevalence and mortality Ytterstad E, Moe PC, Hjalmarsen A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:625-636 Published Date: 23 March 2016

CORRIGENDUM

The Short Physical Performance Battery is a discriminative tool for identifying patients with COPD at risk of disability [Corrigendum] Bernabeu-Mora R, Medina-Mirapeix F, Llamazares-Herrán E, García-Guillamón G, Giménez-Giménez LM, SánchezNieto JM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:623-624 Published Date: 24 March 2016

STUDY PROTOCOL

POPE study: rationale and methodology of a study to phenotype patients with COPD in Central and Eastern Europe Zbozinkova Z, Barczyk A, Tkacova R, Valipour A, Tudoric N, Zykov K, Somfay A, Miravitlles M, Koblizek V International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:611-622 Published Date: 22 March 2016

ORIGINAL RESEARCH

Physical exercise is effective in preventing cigarette smoke-induced pulmonary oxidative response in mice Nesi RT, Souza PS, Santos GP, Thirupathi A, Menegali BT, Silveira PC, Silva LA, Valença SS, Pinho RA International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:603-610 Published Date: 22 March 2016

ORIGINAL RESEARCH

Inhalation errors due to device switch in patients with chronic obstructive pulmonary disease and asthma: critical health and economic issues Roggeri A, Micheletto C, Roggeri DP International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:597-602 Published Date: 21 March 2016

ORIGINAL RESEARCH

Pharmacokinetics and safety of olodaterol administered with the Respimat Soft Mist inhaler in subjects with impaired hepatic or renal function Kunz C, Luedtke D, Unseld A, Hamilton A, Halabi A, Wein M, Formella S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:585-595 Published Date: 18 March 2016

ORIGINAL RESEARCH

COPD exacerbation care bundle improves standard of care, length of stay, and readmission rates Parikh R, Shah TG, Tandon R, International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:577-583 Published Date: 17 March 2016

ORIGINAL RESEARCH

Relationship of airflow limitation severity with work productivity reduction and sick leave in a Japanese working population Onoue A, Omori H, Katoh T, Kubota K, Nonami Y, Ogata Y, Inoue H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:567-575 Published Date: 16 March 2016

ORIGINAL RESEARCH

Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD Zhao P, Yang LP, Li JS, Li Y, Tian YG, Li SY International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:553-566 Published Date: 15 March 2016

ORIGINAL RESEARCH

Cognitive status among patients with chronic obstructive pulmonary disease Roncero C, Campuzano AI, Quintano JA, Molina J, Pérez J, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:543-551 Published Date: 16 March 2016

REVIEW

The optimum timing to wean invasive ventilation for patients with AECOPD or COPD with pulmonary infection Song YL, Chen RC, Zhan QY, Chen SJ, Luo ZJ, Ou JX, Wang C International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:535-542 Published Date: 14 March 2016

ORIGINAL RESEARCH

Microparticles in sputum of COPD patients: a potential biomarker of the disease? Lacedonia D, Carpagnano GE, Trotta T, Palladino GP, Panaro MA, Zoppo LD, Foschino Barbaro MP, Porro C International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:527-533 Published Date: 14 March 2016

EXPERT OPINION

Treatment of patients with COPD and recurrent exacerbations: the role of infection and inflammation Santos S, Marin A, Serra-Batlles J, de la Rosa D, Solanes I, Pomares X, López-Sánchez M, Muñoz-Esquerre M, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:515-525 Published Date: 11 March 2016

ORIGINAL RESEARCH

COPD phenotypes on computed tomography and its correlation with selected lung function variables in severe patients da Silva SMD, Paschoal IA, De Capitani EM, Moreira MM, Palhares LC, Pereira MC International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:503-513 Published Date: 16 March 2016

ORIGINAL RESEARCH

Whakawhanaungatanga: the importance of culturally meaningful connections to improve uptake of pulmonary rehabilitation by Māori with COPD – a qualitative study Levack WMM, Jones B, Grainger R, Boland P, Brown M, Ingham TR International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:489-501 Published Date: 9 March 2016

ORIGINAL RESEARCH

COPD assessment test and severity of airflow limitation in patients with asthma, COPD, and asthma–COPD overlap syndrome Kurashima K, Takaku Y, Ohta C, Takayanagi N, Yanagisawa T, Sugita Y International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:479-487 Published Date: 4 March 2016

ORIGINAL RESEARCH

COPD disease severity and innate immune response to pathogen-associated molecular patterns Fan VS, Gharib SA, Martin TR, Wurfel MM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:467-477 Published Date: 4 March 2016

ORIGINAL RESEARCH

Incidence and outcomes of patients hospitalized with COPD exacerbation with and without pneumonia Søgaard M, Madsen M, Løkke A, Hilberg O, Sørensen HT, Thomsen RW International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:455-465 Published Date: 2 March 2016

REVIEW

Bacterial–viral load and the immune response in stable and exacerbated COPD: significance and therapeutic prospects D’Anna SE, Balbi B, Cappello F, Carone M, Di Stefano A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:445-453 Published Date: 1 March 2016

REVIEW

Striving for optimal bronchodilation: focus on olodaterol Incorvaia C, Montagni M, Makri E, Riario-Sforza GG, Ridolo E International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:439-444 Published Date: 1 March 2016

ORIGINAL RESEARCH

Risk stratification for COPD diagnosis through an active search strategy in primary care Marcos PJ, Malo de Molina R, Casamor R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:431-437 Published Date: 1 March 2016

ORIGINAL RESEARCH

Validity of COPD diagnoses reported through nationwide health insurance systems in the People’s Republic of China Kurmi OP, Vaucher J, Xiao D, Holmes MV, Guo Y, Davis KJ, Wang C, Qin H, Turnbull I, Peng P, Bian Z, Clarke R, Li L, Chen Y, Chen Z International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:419-430 Published Date: 1 March 2016

CORRIGENDUM

The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia [Corrigendum] Duman D, Aksoy E, Agca MC, Kocak ND, Ozmen I, Akturk UA, Gungor S, Tepetam FM, Eroglu SA, Oztas S, Karakurt Z International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:417-418 Published Date: 1 March 2016

ORIGINAL RESEARCH

A cross-sectional study to assess inhalation device handling and patient satisfaction in COPD Miravitlles M, Montero-Caballero J, Richard F, Santos S, Garcia-Rivero JL, Ortega F, Ribera X International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:407-415 Published Date: 26 February 2016

ORIGINAL RESEARCH

Chronic obstructive pulmonary disease and cognitive impairment in the Chinese elderly population: a large national survey Yin P, Ma Q, Wang L, Lin P, Zhang M, Qi S, Wang Z International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:399-406 Published Date: 25 February 2016

ORIGINAL RESEARCH

Determinants of successful completion of pulmonary rehabilitation in COPD Brown AT, Hitchcock J, Schumann C, Wells JM, Dransfield MT, Bhatt SP International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:391-397 Published Date: 25 February 2016

ORIGINAL RESEARCH

Early response to inhaled bronchodilators and corticosteroids as a predictor of 12-month treatment responder status and COPD exacerbations Calverley PM, Postma DS, Anzueto AR, Make BJ, Eriksson G, Peterson S, Jenkins CR International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:381-390 Published Date: 25 February 2016

ORIGINAL RESEARCH

Development of a spirometry T-score in the general population Lee SW, Kim HK, Baek S, Jung JY, Kim YS, Lee JS, Lee SD, Mannino DM, Oh YM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:369-379 Published Date: 23 February 2016

ORIGINAL RESEARCH

Explaining the link between access-to-care factors and health care resource utilization among individuals with COPD Kim M, Ren J, Tillis W, Asche CV, Kim IK, Kirkness CS International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:357-367 Published Date: 22 February 2016

ORIGINAL RESEARCH

Mortality and economic burden of Krasnoyarsk region, Russia, caused by regular tobacco usage Artyukhov IP, Arshukova IL, Dobretsova EA, Shulmin AV International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:351-355 Published Date: 22 February 2016

ORIGINAL RESEARCH

COPD characteristics and socioeconomic burden in Hellenic correctional institutions Bania EG, Daniil Z, Hatzoglou C, Alexopoulos EC, Mitsiki E, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:341-349 Published Date: 12 February 2016

ORIGINAL RESEARCH

Feasibility of spirometry in primary care to screen for COPD: a pilot study Giraud V, Beauchet A, Gomis T, Chinet T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:335-340 Published Date: 12 February 2016

STUDY PROTOCOL

Study protocol for a randomized controlled trial of telephone-delivered cognitive behavior therapy compared with befriending for treating depression and anxiety in older adults with COPD Doyle C, Dunt D, Ames D, Fearn M, You E, Bhar S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:327-334 Published Date: 12 February 2016

ORIGINAL RESEARCH

Self-management of health care behaviors for COPD: a systematic review and meta-analysis Jolly K, Majothi S, Sitch AJ, Heneghan NR, Riley RD, Moore DJ, Bates EJ, Turner AM, Bayliss SE, Price MJ, Singh SJ, Adab P, Fitzmaurice DA, Jordan RE International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:305-326 Published Date: 17 February 2016

ORIGINAL RESEARCH

Responsiveness of blood and sputum inflammatory cells in Japanese COPD patients, non-COPD smoking controls, and non-COPD nonsmoking controls Kawayama T, Kinoshita T, Matsunaga K, Kobayashi A, Hayamizu T, Johnson M, Hoshino T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:295-303 Published Date: 10 February 2016

ORIGINAL RESEARCH

Relevance of dosage in adherence to treatment with long-acting anticholinergics in patients with COPD Izquierdo JL, Paredero JM, Piedra R International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:289-293 Published Date: 10 February 2016

ORIGINAL RESEARCH

Impact of GOLD groups of chronic pulmonary obstructive disease on surgical complications Kim HJ, Lee J, Park YS, Lee CH, Lee SM, Yim JJ, Yoo CG, Kim YW, Han SK, Choi SM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:281-287 Published Date: 10 February 2016

ORIGINAL RESEARCH

Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations Mahboub B, Alzaabi A, Iqbal MN, Salhi H, Lahlou A, Tariq L, El Hasnaoui A International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:273-280 Published Date: 5 February 2016

ORIGINAL RESEARCH

Functional respiratory imaging to assess the interaction between systemic roflumilast and inhaled ICS/LABA/LAMA Vos W, Hajian B, De Backer J, Van Holsbeke C, Vinchurkar S, Claes R, Hufkens A, Parizel PM, Bedert L, De Backer W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:263-271 Published Date: 4 February 2016

ORIGINAL RESEARCH

Determinants of change in physical activity during moderate-to-severe COPD exacerbation Esteban C, Quintana JM, Garcia-Gutierrez S, Anton-Ladislao A, Gonzalez N, Baré M, Fernández de Larrea N, RivasRuiz F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:251-261 Published Date: 3 February 2016

ORIGINAL RESEARCH

Depression, body mass index, and chronic obstructive pulmonary disease – a holistic approach Catalfo G, Crea L, Lo Castro T, Magnano San Lio F, Minutolo G, Siscaro G, Vaccino N, Crimi N, Aguglia E International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:239-249 Published Date: 4 February 2016

ORIGINAL RESEARCH

Antioxidant activity of pomegranate juice reduces emphysematous changes and injury secondary to cigarette smoke in an animal model and human alveolar cells Husari A, Hashem Y, Bitar H, Dbaibo G, Zaatari G, El Sabban M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:227-237 Published Date: 3 February 2016

ORIGINAL RESEARCH

No association between exacerbation frequency and stroke in patients with COPD Windsor C, Herrett E, Smeeth L, Quint JK International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:217-225 Published Date: 2 February 2016

ORIGINAL RESEARCH

“Frequent exacerbator” is a phenotype of poor prognosis in Japanese patients with chronic obstructive pulmonary disease Tomioka R , Kawayama T, Suetomo M, Kinoshita T, Tokunaga Y, Imaoka H, Matsunaga K, Okamoto M, Hoshino T International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:207-216 Published Date: 3 February 2016

ORIGINAL RESEARCH

The lung function profile of once-daily tiotropium and olodaterol via Respimat® is superior to that of twice-daily salmeterol and fluticasone propionate via Accuhaler® (ENERGITO® study) Beeh KM, Derom E, Echave-Sustaeta J, Grönke L, Hamilton A, Zhai D, Bjermer L International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:193-205 Published Date: 3 February 2016

CORRIGENDUM

Development of an integral assessment approach of health status in patients with obstructive airway diseases: the CORONA study [Corrigendum] van den Akker EF, van‘t Hul AJ, Chavannes NH, Braunstahl GJ, van Bruggen A, Rutten-van Mölken MP, in ‘t Veen JC International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:191-192 Published Date: 2 February 2016

ORIGINAL RESEARCH

Differences in the effects of Asian dust on pulmonary function between adult patients with asthma and those with asthma–chronic obstructive pulmonary disease overlap syndrome Watanabe M, Noma H, Kurai J, Sano H, Ueda Y, Mikami M, Yamamoto H, Tokuyasu H, Kato K, Konishi T, Tatsukawa T, Shimizu E, Kitano H International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:183-190 Published Date: 28 January 2016

ORIGINAL RESEARCH

The changing nature of chronic care and coproduction of care between primary care professionals and patients with COPD and their informal caregivers Cramm JM, Nieboer AP International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:175-182 Published Date: 27 January 2016

ORIGINAL RESEARCH

Effect of salmeterol/fluticasone combination on the dynamic changes of lung mechanics in mechanically ventilated COPD patients: a prospective pilot study Chen WC, Chen HH, Chiang CH, Lee YC, Yang KY International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:167-174 Published Date: 27 January 2016

ORIGINAL RESEARCH

Association of incidental emphysema with annual lung function decline and future development of airflow limitation Koo HK, Jin KN, Kim DK, Chung HS, Lee CH International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:161-166 Published Date: 29 January 2016

ORIGINAL RESEARCH

Sex differences in reported and objectively measured sleep in COPD Theorell-Haglöw J, Ólafsdóttir IS, Benediktsdóttir B, Gíslason T, Lindberg E, Janson C International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:151-160 Published Date: 25 January 2016

LETTER

A possible pathological link among swallowing dysfunction, gastro-esophageal reflex, and sleep apnea in acute exacerbation in COPD patients Teramoto S International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:147-150 Published Date: 27 January 2016

ORIGINAL RESEARCH

Differences in outcomes between GOLD groups in patients with COPD in the TIOSPIR® trial Dusser D, Wise RA, Dahl R, Anzueto A, Carter K, Fowler A, Calverley PM International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:133-145 Published Date: 20 January 2016

ORIGINAL RESEARCH

Cost-effectiveness of combination therapy umeclidinium/vilanterol versus tiotropium in symptomatic COPD Spanish patients Miravitlles M, Gáldiz JB, Huerta A, Villacampa A, Carcedo D, Garcia-Rio F International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:123-132 Published Date: 18 January 2016

ORIGINAL RESEARCH

COPD exacerbations associated with the modified Medical Research Council scale and COPD assessment test among Humana Medicare members Pasquale MK, Xu Y, Baker CL, Zou KH, Teeter JG, Renda AM, Davis CC, Lee TC, Bobula J International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:111-121 Published Date: 14 January 2016

ORIGINAL RESEARCH

Factors contributing to quality of life in COPD patients in South Korea Kwon HY, Kim E International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:103-109 Published Date: 13 January 2016

ORIGINAL RESEARCH

Characteristics of reversible and nonreversible COPD and asthma and COPD overlap syndrome patients: an analysis of salbutamol Easyhaler data Müller V, Gálffy G, Orosz M, Kováts Z, Odler B, Selroos O, Tamási L International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:93-101 Published Date: 12 January 2016

LETTER

The effect of postgastrectomy reflux on lung functions Atay K International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:91-92 Published Date: 11 January 2016

REVIEW

Roflumilast: a review of its use in the treatment of COPD Wedzicha JA, Calverley PMA, Rabe KF International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:81-90 Published Date: 6 January 2016

REVIEW

Specific role of combination aclidinium: formoterol in the treatment of chronic obstructive pulmonary disease Matera MG, Sanduzzi A, Cazzola M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:73-79 Published Date: 5 January 2016

ORIGINAL RESEARCH

Impact of individualized care on readmissions after a hospitalization for acute exacerbation of COPD Adamson SL, Burns J, Camp PG, Sin DD, van Eeden SF International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:61-71 Published Date: 5 January 2016

ORIGINAL RESEARCH

Age-related annual decline of lung function in patients with COPD Kim SJ, Lee J, Park YS, Lee CH, Yoon HI, Lee SM, Yim JJ, Kim YW, Han SK, Yoo CG International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:51-60 Published Date: 30 December 2015

ORIGINAL RESEARCH

Impact of chronic obstructive pulmonary disease on postoperative recurrence in patients with resected non-small-cell lung cancer Qiang GL, Liang CY, Xiao F, Yu QD, Wen HS, Song ZY, Tian YC, Shi B, Guo YQ, Liu DR International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:43-49 Published Date: 29 December 2015

ORIGINAL RESEARCH

Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway Dong R, Xie L, Zhao K, Zhang Q, Zhou M, He P International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:31-41 Published Date: 22 December 2015

ORIGINAL RESEARCH

Association of blood eosinophils and plasma periostin with FEV1 response after 3-month inhaled corticosteroid and long-acting beta2-agonist treatment in stable COPD patients Park HY, Lee H, Koh WJ, Kim S, Jeong I, Koo HK, Kim TH, Kim JW, Kim WJ, Oh YM, Sin DD, Lim SY, Lee SD International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:23-30 Published Date: 22 December 2015

ORIGINAL RESEARCH

The relationship between the number of natural teeth and airflow obstruction: a cross-sectional study using data from the Korean National Health and Nutrition Examination Survey Kim SW, Han KD, Kim SY, Park CK, Rhee CK, Yoon HK International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:13-21 Published Date: 21 December 2015

ORIGINAL RESEARCH

Efficacy and safety of fluticasone furoate/vilanterol or tiotropium in subjects with COPD at cardiovascular risk Covelli H, Pek B, Schenkenberger I, Scott-Wilson C, Emmett A, Crim C International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1-12 Published Date: 18 December 2015

REVIEW

Exacerbations of COPD Pavord ID, Jones PW, Burgel PR, Rabe KF International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:21-30 Published Date: 19 February 2016

REVIEW

COPD: the patient perspective Jones PW, Watz H, Wouters EFM, Cazzola M International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:13-20 Published Date: 19 February 2016

REVIEW

Diagnosis, assessment, and phenotyping of COPD: beyond FEV1 Lange P, Halpin DM, O’Donnell DE, MacNee W International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3-12 Published Date: 18 February 2016

EDITORIAL

Highlights and hot topics in the management of COPD: where are we heading? Agustí A, Jones PW, Vogelmeier C International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:1-2 Published Date: 18 February 2016

CORRIGENDUM

Endoscopic bronchial valve treatment: patient selection and special considerations [Corrigendum] Eberhardt R, Gompelmann D, Herth FJF, Schuhmann M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2675-2676 Published Date: 18 December 2015

ORIGINAL RESEARCH

Frequency and risk factors of COPD exacerbations and hospitalizations: a nationwide study in Greece (Greek Obstructive Lung Disease Epidemiology and health ecoNomics: GOLDEN study) Alexopoulos EC, Malli F, Mitsiki E, Bania EG, Varounis C, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2665-2674 Published Date: 11 December 2015

ORIGINAL RESEARCH

Adherence to GOLD guideline treatment recommendations among pulmonologists in Turkey Sen E, Guclu SZ, Kibar I, Ocal U, Yilmaz V, Celik O, Cimen F, Topcu F, Orhun M, Tereci H, Konya A, Ar I, Saryal S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2657-2663 Published Date: 10 December 2015

ORIGINAL RESEARCH

Systems pharmacology-based approach for dissecting the active ingredients and potential targets of the Chinese herbal Bufei Jianpi formula for the treatment of COPD Zhao P, Li JS, Li Y, Tian YG, Wang YH, Zheng CL International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2633-2656 Published Date: 7 December 2015

ORIGINAL RESEARCH

Increased hypoxemia in patients with COPD and pulmonary hypertension undergoing bronchoscopy with biopsy Neuman Y, Koslow M, Matveychuk A, Bar-Sef A, Guber A, Shitrit D International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2627-2632 Published Date: 7 December 2015

ORIGINAL RESEARCH

The Short Physical Performance Battery is a discriminative tool for identifying patients with COPD at risk of disability Bernabeu-Mora R, Medina-Mirapeix F, Llamazares-Herrán E, García-Guillamón G, Giménez-Giménez LM, SánchezNieto JM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2619-2626 Published Date: 3 December 2015

ORIGINAL RESEARCH

COPD exacerbation frequency and its association with health care resource utilization and costs Dhamane AD, Moretz C, Zhou Y, Burslem K, Saverno K, Jain G, Renda A, Kaila S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2609-2618 Published Date: 3 December 2015

REVIEW

Switching treatments in COPD: implications for costs and treatment adherence Braido F, Lavorini F, Blasi F, Baiardini I, Canonica GW International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2601-2608 Published Date: 3 December 2015

ORIGINAL RESEARCH

The analyses of risk factors for COPD in the Li ethnic group in Hainan, People’s Republic of China Ding YP, Xu JX, Yao JJ, Chen Y, He P, Ouyang YH, Niu H, Tian ZJ, Sun P International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2593-2600 Published Date: 30 November 2015

ORIGINAL RESEARCH

Bacterial flora in the sputum and comorbidity in patients with acute exacerbations of COPD Boixeda R, Almagro P, Díez-Manglano J, Cabrera FJ, Recio J, Martin-Garrido I, Soriano JB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2581-2591 Published Date: 1 December 2015

ORIGINAL RESEARCH

The chronic obstructive pulmonary disease assessment test improves the predictive value of previous exacerbations for poor outcomes in COPD Miravitlles M, García-Sidro P, Fernández-Nistal A, Buendía MJ, Espinosa de los Monteros MJ, Esquinas C, Molina J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2571-2579 Published Date: 30 November 2015

ORIGINAL RESEARCH

Comparison of exercise capacity in COPD and other etiologies of chronic respiratory failure requiring non-invasive mechanical ventilation at home: retrospective analysis of 1-year follow-up Salturk C, Karakurt Z, Takir HB, Balci M, Kargin F, Mocin OY, Gungor G, Ozmen I, Oztas S, Yalcinsoy M, Evin R, Ozturk M, Adiguzel N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2559-2569 Published Date: 26 November 2015

ORIGINAL RESEARCH

Effects of 12 weeks of aerobic training on autonomic modulation, mucociliary clearance, and aerobic parameters in patients with COPD Leite MR, Ramos EMC, Kalva-Filho CA, Freire APCF, Silva BSA, Nicolino J, Toledo-Arruda AC, Papoti M, Vanderlei LCM, Ramos D International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2549-2557 Published Date: 23 November 2015

PERSPECTIVES

Applying the wisdom of stepping down inhaled corticosteroids in patients with COPD: a proposed algorithm for clinical practice Kaplan AG International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2535-2548 Published Date: 20 November 2015

ORIGINAL RESEARCH

Computed tomography measurement of pulmonary artery for diagnosis of COPD and its comorbidity pulmonary hypertension Chen X, Liu K, Wang Z, Zhu Y, Zhao Y, Kong H, Xie W, Wang H International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2525-2533 Published Date: 18 November 2015

ORIGINAL RESEARCH

Hyperuricemia is a biomarker of early mortality in patients with chronic obstructive pulmonary disease Zhang X, Liu LJ, Liang R, Jin SD International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2519-2523 Published Date: 26 November 2015

ORIGINAL RESEARCH

Comparative efficacy of long-acting muscarinic antagonist monotherapies in COPD: a systematic review and network meta-analysis Ismaila AS, Huisman EL, Punekar YS, Karabis A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2495-2517 Published Date: 16 November 2015

ORIGINAL RESEARCH

Categorization of COPD patients in Turkey via GOLD 2013 strategy document: ALPHABET study Gunen H, Yilmaz M, Aktas O, Ergun P, Ortakoylu MG, Demir A, Cetinkaya P, Gurgun A, Otlu M, Cilli A, Yilmaz U, Kokturk N, Candemir I, Yakar HI, Ar I, Konya A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2485-2494 Published Date: 13 November 2015

ORIGINAL RESEARCH

The risk of burn injury during long-term oxygen therapy: a 17-year longitudinal national study in Sweden Tanash HA, Huss F, Ekström M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2479-2484 Published Date: 13 November 2015

ORIGINAL RESEARCH

The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia Duman D, Aksoy E, Agca MC, Kocak ND, Ozmen I, Akturk UA, Gungor S, Tepetam FM, Eroglu SA, Oztas S, Karakurt Z International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2469-2478 Published Date: 11 November 2015

ORIGINAL RESEARCH

COPD in Taiwan: a National Epidemiology Survey Cheng SL, Chan MC, Wang CC, Lin CH, Wang HC, Hsu JY, Hang LW, Chang CJ, Perng DW, Yu CJ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2459-2467 Published Date: 11 November 2015

PERSPECTIVES

COPD: it is time to change! Tantucci C, Pini L International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2451-2457 Published Date: 11 November 2015

ORIGINAL RESEARCH

Predicting frequent COPD exacerbations using primary care data Kerkhof M, Freeman D, Jones R, Chisholm A, Price DB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2439-2450 Published Date: 9 November 2015

METHODOLOGY

The EFFECT trial: evaluating exacerbations, biomarkers, and safety outcomes with two dose levels of fluticasone propionate/formoterol in COPD Papi A, Jones PW, Dalvi PS, McAulay K, McIver T, Dissanayake S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2431-2438 Published Date: 9 November 2015

ORIGINAL RESEARCH

The one repetition maximum test and the sit-to-stand test in the assessment of a specific pulmonary rehabilitation program on peripheral muscle strength in COPD patients Zanini A, Aiello M, Cherubino F, Zampogna E, Azzola A, Chetta A, Spanevello A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2423-2430 Published Date: 11 November 2015

METHODOLOGY

Development of an integral assessment approach of health status in patients with obstructive airway diseases: the CORONA study van den Akker EF, van ‘t Hul AJ, Chavannes NH, Braunstahl GJ, van Bruggen A, Rutten-van Mölken MP, in ‘t Veen JC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2413-2422 Published Date: 6 November 2015

ORIGINAL RESEARCH

Increased serum TRAIL and DR5 levels correlated with lung function and inflammation in stable COPD patients Wu YQ, Shen YC, Zhang JL, Wan C, Wang T, Xu D, Yang T, Wen FQ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2405-2412 Published Date: 6 November 2015

ORIGINAL RESEARCH

Triple therapy with salmeterol/fluticasone propionate 50/250 plus tiotropium bromide improve lung function versus individual treatments in moderate-to-severe Japanese COPD patients: a randomized controlled trial – Evaluation of Airway sGaw after treatment with tripLE Saito T, Takeda A, Hashimoto K, Kobayashi A, Hayamizu T, Hagan GW International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2393-2404 Published Date: 4 November 2015

ORIGINAL RESEARCH

Current care services provided for patients with COPD in the Eastern province in Saudi Arabia: a descriptive study Alsubaiei ME, Cafarella PA, Frith PA, McEvoy RD, Effing TW International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2379-2391 Published Date: 4 November 2015

CORRIGENDUM

Pulmonary hemodynamic profile in chronic obstructive pulmonary disease [Corrigendum] Portillo K, Torralba Y, Blanco I, Burgos F, Rodriguez-Roisin R, Rios J, Roca J, Barberà JA International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2377-2378 Published Date: 4 November 2015

ORIGINAL RESEARCH

The efficacy and safety of triple inhaled treatment in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis using Bayesian methods Kwak MS, Kim E, Jang EJ, Kim HJ, Lee CH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2365-2376 Published Date: 3 November 2015

ORIGINAL RESEARCH

Prevalence of chronic obstructive pulmonary disease in asymptomatic smokers Sansores RH, Velázquez-Uncal M, Pérez-Bautista O, Villalba-Caloca J, Falfán-Valencia R, Ramírez-Venegas A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2357-2363 Published Date: 2 November 2015

REVIEW

Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease Ramadan WH, Kabbara WK, El Khoury GM, Al Assir SA International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2347-2356 Published Date: 30 October 2015

ORIGINAL RESEARCH

The importance of inhaler devices: the choice of inhaler device may lead to suboptimal adherence in COPD patients Darbà J, Ramírez G, Sicras A, Francoli P, Torvinen S, Sánchez-de la Rosa R International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2335-2345 Published Date: 29 October 2015

ORIGINAL RESEARCH

The phenotype of concurrent chronic bronchitis and frequent exacerbations in patients with severe COPD attending Swedish secondary care units Sundh J, Johansson G, Larsson K, Lindén A, Löfdahl CG, Sandström T, Janson C International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2327-2334 Published Date: 28 October 2015

ORIGINAL RESEARCH

Erdosteine reduces inflammation and time to first exacerbation postdischarge in hospitalized patients with AECOPD Moretti M, Fagnani S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2319-2325 Published Date: 28 October 2015

ORIGINAL RESEARCH

Long-term effects of gastrectomy in patients with spirometry-defined COPD and patients at risk of COPD: a case-control study Saito H, Nomura K, Abe S, Motegi T, Ishii T, Hattori K, Kusunoki Y, Gemma A, Kida K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2311-2318 Published Date: 29 October 2015

ORIGINAL RESEARCH

Health care and social care costs of pneumonia in Denmark: a register-based study of all citizens and patients with COPD in three municipalities Brogaard SL, Nielsen MB, Nielsen LU, Albretsen TM, Bundgaard M, Anker N, Appel M, Gustavsen K, Lindkvist RM, Skjoldan A, Breinhild G, Poulsen PB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2303-2309 Published Date: 28 October 2015

ORIGINAL RESEARCH

Forecasting COPD hospitalization in the clinic: optimizing the chronic respiratory questionnaire Abascal-Bolado B, Novotny PJ, Sloan JA, Karpman C, Dulohery MM, Benzo RP International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2295-2301 Published Date: 22 October 2015

ORIGINAL RESEARCH

Time trends in coronary revascularization procedures among people with COPD: analysis of the Spanish national hospital discharge data (2001–2011) de Miguel-Díez J, Jiménez-García R, Hernández-Barrera V, Carrasco-Garrido P, Bueno H, Puente-Maestu L, Jimenez-Trujillo I, Alvaro-Meca A, Esteban-Hernandez J, de Andrés AL International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2285-2294 Published Date: 22 October 2015

REVIEW

The stats are in: an update on statin use in COPD Carlson AA, Smith EA, Reid DJ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2277-2284 Published Date: 22 October 2015

ORIGINAL RESEARCH

Zabofloxacin versus moxifloxacin in patients with COPD exacerbation: a multicenter, doubleblind, double-dummy, randomized, controlled, Phase III, non-inferiority trial Rhee CK, Chang JH, Choi EG, Kim HK, Kwon YS, Kyung SY, Lee JH, Park MJ, Yoo KH, Oh YM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2265-2275 Published Date: 22 October 2015

ORIGINAL RESEARCH

Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD Assessment Test Dai MY, Qiao JP, Xu YH, Fei GH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2257-2263 Published Date: 20 October 2015

REVIEW

Candidate genes for COPD: current evidence and research Kim WJ, Lee SD International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2249-2255 Published Date: 19 October 2015

ORIGINAL RESEARCH

Medicinal clays improve the endurance of loaded inspiratory muscles in COPD: a randomized clinical trial of nonpharmacological treatment Baldi S, Pinna GD, Bruschi C, Caldara F, Maestri R, Dacosto E, Rezzani A, Popovich E, Bellinzona E, Crotti P, Montemartini S, Fracchia C International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2235-2248 Published Date: 23 October 2015

REVIEW

Chronic obstructive lung disease and posttraumatic stress disorder: current perspectives Abrams TE, Blevins A, Vander Weg MW International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2219-2233 Published Date: 15 October 2015

ORIGINAL RESEARCH

The inevitable drift to triple therapy in COPD: an analysis of prescribing pathways in the UK Brusselle G, Price D, Gruffydd-Jones K, Miravitlles M, Keininger DL, Stewart R, Baldwin M, Jones RC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2207-2217 Published Date: 15 October 2015

LETTER

A comprehensive assessment using COPD assessment test scoring and modified Medical Research Council dyspnea scoring is necessary for personalized therapy for COPD patients Teramoto S, Inui T, Hizawa N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2203-2206 Published Date: 15 October 2015

ORIGINAL RESEARCH

A new approach to assess COPD by identifying lung function break-points Eriksson G, Jarenbäck L, Peterson S, Ankerst J, Bjermer L, Tufvesson E International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2193-2202 Published Date: 14 October 2015

ORIGINAL RESEARCH

Effect of tiotropium on lung function decline in early-stage of chronic obstructive pulmonary disease patients: propensity score-matched analysis of real-world data Lee HY, Choi SM, Lee J, Park YS, Lee CH, Kim DK, Lee SM, Yoon HI, Yim JJ, Kim YW, Han SK, Yoo CG International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2185-2192 Published Date: 13 October 2015

ORIGINAL RESEARCH

A randomized multicenter Phase II study of perioperative tiotropium intervention in gastric cancer patients with chronic obstructive pulmonary disease Fushida S, Oyama K, Kaji M, Hirono Y, Kinoshita J, Tsukada T, Nezuka H, Nakano T, Noto M, Nishijima K, Fujimura T, Ohta T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2177-2183 Published Date: 12 October 2015

ORIGINAL RESEARCH

Biomarker-based detection of asthma–COPD overlap syndrome in COPD populations Tamada T, Sugiura H, Takahashi T, Matsunaga K, Kimura K, Katsumata U, Takekoshi D, Kikuchi T, Ohta K, Ichinose M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2169-2176 Published Date: 9 October 2015

ORIGINAL RESEARCH

The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan– Anseong) cohort Joshi P, Kim WJ, Lee SA International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2159-2168 Published Date: 8 October 2015

CORRIGENDUM

Endoscopic bronchial valve treatment: patient selection and special considerations Eberhardt R, Gompelmann D, Herth FJF, Schuhmann M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2147-2157 Published Date: 8 October 2015

REVIEW

Lung transplantation in chronic obstructive pulmonary disease: patient selection and special considerations Lane CR, Tonelli AR International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2137-2146 Published Date: 12 October 2015

ORIGINAL RESEARCH

A longitudinal, retrospective cohort study on the impact of roflumilast on exacerbations and economic burden among chronic obstructive pulmonary disease patients in the real world Wan Y, Sun SX, Corman S, Huang X, Gao X, Shorr AF International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2127-2136 Published Date: 7 October 2015

ORIGINAL RESEARCH

Wheezing, a significant clinical phenotype of COPD: experience from the Taiwan Obstructive Lung Disease Study Huang WC, Tsai YH, Wei YF, Kuo PH, Tao CW, Cheng SL, Lee CH, Wu YK, Chen NH, Hsu WH, Hsu JY, Wang CC, Lin MS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2121-2126 Published Date: 7 October 2015

ORIGINAL RESEARCH

A real-world evaluation of indacaterol and other bronchodilators in COPD: the INFLOW study Juvelekian G, El-Sorougi W, Pothirat C, Yunus F, De Guia T, Kuo H, Basu Patnaik S, Pilipovic V International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2109-2120 Published Date: 5 October 2015

ORIGINAL RESEARCH

Prevalence and risk factors for COPD in greenhouse farmers: a large, cross-sectional survey of 5,880 farmers from northeast China Liu S, Ren YG, Wen DL, Chen Y, Chen DH, Li LY, Zhang XH, Zhang YB, Fu S, Li ZH, Xia SY, Wang DL, Chen H, Zhao J, Wang XG International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2097-2108 Published Date: 1 October 2015

LETTER

Laryngopharyngeal reflux COPD to uncover reflux and columnar lined esophagus Kristo I, Riegler M, Schoppmann SF International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2095-2096 Published Date: 30 September 2015

ORIGINAL RESEARCH

Assessment of cognitive impairment in long-term oxygen therapy-dependent COPD patients Karamanli H, Ilik F, Kayhan F, Pazarli AC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2087-2094 Published Date: 29 September 2015

ORIGINAL RESEARCH

Investigation of Pneumocystis jirovecii colonization in patients with chronic pulmonary diseases in the People’s Republic of China Wang DD, Zheng MQ, Zhang N, An CL International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2079-2085 Published Date: 29 September 2015

ORIGINAL RESEARCH

Acute kidney injury in stable COPD and at exacerbation Barakat MF, McDonald HI, Collier TJ, Smeeth L, Nitsch D, Quint JK International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2067-2077 Published Date: 28 September 2015

ORIGINAL RESEARCH

Comparative effectiveness of budesonide/formoterol combination and tiotropium bromide among COPD patients new to these controller treatments Trudo F, Kern DM, Davis JR, Tunceli O, Zhou S, Graham EL, Strange C, Williams SA International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2055-2066 Published Date: 28 September 2015

METHODOLOGY

Automated continuous quantitative measurement of proximal airways on dynamic ventilation CT: initial experience using an ex vivo porcine lung phantom Yamashiro T, Tsubakimoto M, Nagatani Y, Moriya H, Sakuma K, Tsukagoshi S, Inokawa H, Kimoto T, Teramoto R, Murayama S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2045-2054 Published Date: 25 September 2015

ORIGINAL RESEARCH

Long-term evaluation of home-based pulmonary rehabilitation in patients with COPD Grosbois JM, Gicquello A, Langlois C, Le Rouzic O, Bart F, Wallaert B, Chenivesse C International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2037-2044 Published Date: 25 September 2015

ORIGINAL RESEARCH

Budgetary impact analysis on funding smoking-cessation drugs in patients with COPD in Spain Jiménez-Ruiz CA, Solano-Reina S, Signes-Costa J, Higes-Martinez E, Granda-Orive JI, Lorza-Blasco JJ, RiescoMiranda JA, Altet-Gomez N, Barrueco M, Oyagüez I, Rejas J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2027-2036 Published Date: 24 September 2015

ORIGINAL RESEARCH

Vitamin D deficiency is associated with impaired disease control in asthma–COPD overlap syndrome patients Odler B, Ivancsó I, Somogyi V, Benke K, Tamási L, Gálffy G, Szalay B, Müller V International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2017-2025 Published Date: 24 September 2015

ORIGINAL RESEARCH

Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods Shimizu K, Yoshii Y, Morozumi M, Chiba N, Ubukata K, Uruga H, Hanada S, Saito N, Kadota T, Ito S, Wakui H, Takasaka N, Minagawa S, Kojima J, Hara H, Numata T, Kawaishi M, Saito K, Araya J, Kaneko Y, Nakayama K, Kishi K, Kuwano K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2009-2016 Published Date: 23 September 2015

ORIGINAL RESEARCH

Proteoglycan 4 is a diagnostic biomarker for COPD Lee KY, Chuang HC, Chen TT, Liu WT, Su CL, Feng PH, Chiang LL, Bien MY, Ho SC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1999-2007 Published Date: 18 September 2015

ORIGINAL RESEARCH

Effects of a helium/oxygen mixture on individuals’ lung function and metabolic cost during submaximal exercise for participants with obstructive lung diseases Häussermann S, Schulze A, Katz IM, Martin AR, Herpich C, Hunger T, Texereau J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1987-1997 Published Date: 21 September 2015

ORIGINAL RESEARCH

Assessments of endothelial function and arterial stiffness are reproducible in patients with COPD Rodriguez-Miguelez P, Seigler N, Bass L, Dillard TA, Harris RA International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1977-1986 Published Date: 16 September 2015

ORIGINAL RESEARCH

Protein networks in induced sputum from smokers and COPD patients Baraniuk JN, Casado B, Pannell LK, McGarvey PB, Boschetto P, Luisetti M, Iadarola P International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1957-1975 Published Date: 15 September 2015

ORIGINAL RESEARCH

Factors associated with the prescription of inhaled corticosteroids in GOLD group A and B patients with COPD – subgroup analysis of the Taiwan obstructive lung disease cohort Wei YF, Kuo PH, Tsai YH, Tao CW, Cheng SL, Lee CH, Wu YK, Chen NH, Hsu WH, Hsu JY, Lin MS, Wang CC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1951-1956 Published Date: 14 September 2015

REVIEW

Gastroesophageal reflux disease in COPD: links and risks Lee AL, Goldstein RS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1935-1949 Published Date: 14 September 2015

LETTER

Does roflumilast induce phagocytic activity in COPD patients? Ghosh B, Vanjare NV International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1931-1934 Published Date: 11 September 2015

ORIGINAL RESEARCH

Sonographic evaluation of diaphragmatic dysfunction in COPD patients Scheibe N, Sosnowski N, Pinkhasik A, Vonderbank S, Bastian A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1925-1930 Published Date: 11 September 2015

ORIGINAL RESEARCH

Effect of indacaterol on lung deflation improves cardiac performance in hyperinflated COPD patients: an interventional, randomized, double-blind clinical trial Santus P, Radovanovic D, Di Marco S, Valenti V, Raccanelli R, Blasi F, Centanni S, Bussotti M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1917-1923 Published Date: 11 September 2015

ORIGINAL RESEARCH

Vitamin D deficiency is associated with the severity of COPD: a systematic review and metaanalysis Zhu BY, Zhu BQ, Xiao CL, Zheng ZW International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1907-1916 Published Date: 11 September 2015

ORIGINAL RESEARCH

Respiratory muscle training with normocapnic hyperpnea improves ventilatory pattern and thoracoabdominal coordination, and reduces oxygen desaturation during endurance exercise testing in COPD patients Bernardi E, Pomidori L, Bassal F, Contoli M, Cogo A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1899-1906 Published Date: 10 September 2015

ORIGINAL RESEARCH

Physical inactivity and arterial stiffness in COPD Sievi NA, Franzen D, Kohler M, Clarenbach CF International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1891-1897 Published Date: 10 September 2015

ORIGINAL RESEARCH

Cognitive function and living situation in COPD: is there a relationship with self-management and quality of life? Dulohery MM, Schroeder DR, Benzo RP International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1883-1889 Published Date: 10 September 2015

ORIGINAL RESEARCH

Comparative efficacy of combination bronchodilator therapies in COPD: a network meta-analysis Huisman EL, Cockle SM, Ismaila AS, Karabis A, Punekar YS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1863-1881 Published Date: 9 September 2015

ORIGINAL RESEARCH

The relationship between anthropometric indicators and walking distance in patients with chronic obstructive pulmonary disease Ho SC, Hsu MF, Kuo HP, Wang JY, Chen LF, Lee KY, Chuang HC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1857-1862 Published Date: 8 September 2015

LETTER

Roflumilast in COPD: a Brazilian perspective Stirbulov R, Jardim JR International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1853-1855 Published Date: 8 September 2015

ORIGINAL RESEARCH

Balance impairment and systemic inflammation in chronic obstructive pulmonary disease Tudorache E, Oancea C, Avram C, Fira-Mladinescu O, Petrescu L, Timar B International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1847-1852 Published Date: 8 September 2015

ORIGINAL RESEARCH

Does eosinophilic COPD exacerbation have a better patient outcome than non-eosinophilic in the intensive care unit? Saltürk C, Karakurt Z, Adiguzel N, Kargin F, Sari R, Celik ME, Takir HB, Tuncay E, Sogukpinar O, Ciftaslan N, Mocin O, Gungor G, Oztas S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1837-1846 Published Date: 8 September 2015

ORIGINAL RESEARCH

The relationship between cough-specific quality of life and abdominal muscle endurance, fatigue, and depression in patients with COPD Arikan H, Savci S, Calik-Kutukcu E, Vardar-Yagli N, Saglam M, Inal-Ince D, Coplu L International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1829-1835 Published Date: 7 September 2015

ORIGINAL RESEARCH

Lung function decline rates according to GOLD group in patients with chronic obstructive pulmonary disease Kim J, Yoon HI, Oh YM, Lim SY, Lee JH, Kim TH, Lee SY, Lee JH, Lee SD, Lee CH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1819-1827 Published Date: 7 September 2015

ORIGINAL RESEARCH

Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD Kim SW, Lee JM, Ha JH, Kang HH, Rhee CK, Kim JW, Moon HS, Baek KH, Lee SH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1809-1817 Published Date: 4 September 2015

ORIGINAL RESEARCH

Effect of tele health care on exacerbations and hospital admissions in patients with chronic obstructive pulmonary disease: a randomized clinical trial Ringbæk T, Green A, Laursen LC, Frausing E, Brøndum E, Ulrik CS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1801-1808 Published Date: 3 September 2015

ORIGINAL RESEARCH

Personalized pulmonary rehabilitation and occupational therapy based on cardiopulmonary exercise testing for patients with advanced chronic obstructive pulmonary disease Maekura R, Hiraga T, Miki K, Kitada S, Miki M, Yoshimura K, Yamamoto H, Kawabe T, Mori M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1787-1800 Published Date: 3 September 2015

ORIGINAL RESEARCH

Epidemiology of chronic obstructive pulmonary disease: a population-based study in Krasnoyarsk region, Russia Artyukhov IP, Arshukova IL, Dobretsova EA, Dugina TA, Shulmin AV, Demko IV International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1781-1786 Published Date: 2 September 2015

ORIGINAL RESEARCH

Bronchodilators use in patients with COPD Dong YH, Hsu CL, Li YY, Chang CH, Lai MS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1769-1779 Published Date: 1 September 2015

ORIGINAL RESEARCH

Efficacy and safety of once-daily inhaled umeclidinium/vilanterol in Asian patients with COPD: results from a randomized, placebo-controlled study Zheng JP, Zhong NS, Newlands A, Church A, Goh AH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1753-1767 Published Date: 2 September 2015

ORIGINAL RESEARCH

Is a previous diagnosis of asthma a reliable criterion for asthma–COPD overlap syndrome in a patient with COPD? Barrecheguren M, Román-Rodríguez M, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1745-1752 Published Date: 1 September 2015

ORIGINAL RESEARCH

Low bone mineral density in COPD patients with osteoporosis is related to low daily physical activity and high COPD assessment test scores Liu WT, Kuo HP, Liao TH, Chiang LL, Chen LF, Hsu MF, Chuang HC, Lee KY, Huang CD, Ho SC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1737-1744 Published Date: 1 September 2015

ORIGINAL RESEARCH

Prevalence of quadriceps muscle weakness in patients with COPD and its association with disease severity Kharbanda S, Ramakrishna A, Krishnan S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1727-1735 Published Date: 1 September 2015

ORIGINAL RESEARCH

C-reactive protein levels in stable COPD patients: a case-control study Silva DR, Gazzana MB, Knorst MM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1719-1725 Published Date: 31 August 2015

ORIGINAL RESEARCH

Case finding for COPD in primary care: a qualitative study of the views of health professionals Haroon S, Jordan RE, Fitzmaurice DA, Adab P International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1711-1718 Published Date: 28 August 2015

ORIGINAL RESEARCH

Efficacy of a respiratory rehabilitation exercise training package in hospitalized elderly patients with acute exacerbation of COPD: a randomized control trial Liao LY, Chen KM, Chung WS, Chien JY International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1703-1709 Published Date: 27 August 2015

ORIGINAL RESEARCH

Benzodiazepine use in COPD: empirical evidence from Norway Halvorsen T, Martinussen PE International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1695-1702 Published Date: 27 August 2015

ORIGINAL RESEARCH

Distribution of body mass index among subjects with COPD in the Middle East and North Africa region: data from the BREATHE study Koniski ML, Salhi H, Lahlou A, Rashid N, El Hasnaoui A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1685-1694 Published Date: 26 August 2015

ORIGINAL RESEARCH

Efficacy and safety of the long-acting 2-agonist olodaterol over 4 weeks in Japanese patients with chronic obstructive pulmonary disease Ichinose M, Takizawa A, Izumoto T, Tadayasu Y, Hamilton AL, Kunz C, Fukuchi Y International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1673-1683 Published Date: 20 August 2015

ORIGINAL RESEARCH

Modified Medical Research Council scale vs Baseline Dyspnea Index to evaluate dyspnea in chronic obstructive pulmonary disease Perez T, Burgel PR, Paillasseur JL, Caillaud D, Deslée G, Chanez P, Roche N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1663-1672 Published Date: 18 August 2015

ORIGINAL RESEARCH

Relationship between linear and nonlinear dynamics of heart rate and impairment of lung function in COPD patients Mazzuco A, Medeiros WM, Sperling MP, Souza AS, Alencar MC, Arbex FF, Neder JA, Arena R, Borghi-Silva A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1651-1661 Published Date: 17 August 2015

ORIGINAL RESEARCH

A variant in 3'-untranslated region of KRAS compromises its interaction with hsa-let-7g and contributes to the development of lung cancer in patients with COPD Hu H, Zhang L, Teng G, Wu Y, Chen Y International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1641-1649 Published Date: 17 August 2015

ORIGINAL RESEARCH

Differences in the use of spirometry between rural and urban primary care centers in Spain Márquez-Martín E, Soriano JB, Calle Rubio M, Lopez-Campos JL International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1633-1639 Published Date: 17 August 2015

ORIGINAL RESEARCH

Discrepancies between modified Medical Research Council dyspnea score and COPD assessment test score in patients with COPD Rhee CK, Kim JW, Hwang YI, Lee JH, Jung KS, Lee MG, Yoo KH, Lee SH, Shin KC, Yoon HK International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1623-1631 Published Date: 12 August 2015

ORIGINAL RESEARCH

VitalQPlus: a potential screening tool for early diagnosis of COPD Sui CF, Ming LC, Neoh CF, Ibrahim B International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1613-1622 Published Date: 11 August 2015

ORIGINAL RESEARCH

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data D’Urzo AD, Kerwin EM, Chapman KR, Decramer M, DiGiovanni R, D’Andrea P, Hu H, Goyal P, Altman P International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1599-1612 Published Date: 11 August 2015

ORIGINAL RESEARCH

Thiazolidinediones are associated with a reduced risk of COPD exacerbations Rinne ST, Liu CF, Feemster LC, Collins BF, Bryson CL, O’Riordan TG, Au DH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1591-1597 Published Date: 10 August 2015

ORIGINAL RESEARCH

Major affective disorders in chronic obstructive pulmonary disease compared with other chronic respiratory diseases Pothirat C, Chaiwong W, Phetsuk N, Pisalthanapuna S, Chetsadaphan N, Inchai J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1583-1590 Published Date: 7 August 2015

ORIGINAL RESEARCH

Comorbidities in obstructive lung disease in Korea: data from the fourth and fifth Korean National Health and Nutrition Examination Survey Park HJ, Leem AY, Lee SH, Song JH, Park MS, Kim YS, Kim SK, Chang J, Chung KS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1571-1582 Published Date: 7 August 2015

ORIGINAL RESEARCH

Relationship between blood levels of heavy metals and lung function based on the Korean National Health and Nutrition Examination Survey IV–V Leem AY, Kim SK, Chang J, Kang YA, Kim YS, Park MS, Kim SY, Kim EY, Chung KS, Jung JY International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1559-1570 Published Date: 6 August 2015

ORIGINAL RESEARCH

Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients Ferrari R, Caram LMO, Faganello MM, Sanchez FF, Tanni SE, Godoy I International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1553-1558 Published Date: 6 August 2015

REVIEW

Palliative care in COPD: an unmet area for quality improvement Vermylen JH, Szmuilowicz E, Kalhan R International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1543-1551 Published Date: 6 August 2015

ORIGINAL RESEARCH

Value of systematic intervention for chronic obstructive pulmonary disease in a regional Japanese city based on case detection rate and medical cost Tawara Y, Senjyu H, Tanaka K, Tanaka T, Asai M, Kozu R, Tabusadani M, Honda S, Sawai T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1531-1542 Published Date: 3 August 2015

ORIGINAL RESEARCH

Prevalence of chronic obstructive pulmonary disease among patients with systemic arterial hypertension without respiratory symptoms Rabahi MF, Pereira SA, Silva Júnior JL, Rezende AP, Castro da Costa A, Corrêa KS, Conde MB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1525-1529 Published Date: 31 July 2015

ORIGINAL RESEARCH

Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction Mahmood MQ, Sohal SS, Shukla SD, Ward C, Hardikar A, Noor WD, Muller HK, Knight DA, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1515-1524 Published Date: 4 August 2015

CORRIGENDUM

Efficacy and safety of once-daily glycopyrronium in predominantly Chinese patients with moderate-to-severe chronic obstructive pulmonary disease: the GLOW7 study [Corrigendum] Wang C, Sun T, Huang Y, Humphries M, Bai L, Li L, Wang Q, Kho P, Firth R, D’Andrea P International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1513-1514 Published Date: 30 July 2015

ORIGINAL RESEARCH

Bronchoscopic lung volume reduction by endobronchial valve in advanced emphysema: the first Asian report Park TS, Hong Y, Lee JS, Oh SY, Lee SM, Kim N, Seo JB, Oh YM, Lee SD, Lee SW International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1501-1511 Published Date: 29 July 2015

ORIGINAL RESEARCH

Prevalence, risk factors, and health-related quality of life of osteoporosis in patients with COPD at a community hospital in Taiwan Lin CW, Chen YY, Chen YJ, Liang CY, Lin MS, Chen W International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1493-1500 Published Date: 29 July 2015

ORIGINAL RESEARCH

Is asymptomatic peripheral arterial disease associated with walking endurance in patients with COPD? Sun KS, Lin MS, Chen YJ, Chen YY, Chen SC, Chen W International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1487-1492 Published Date: 29 July 2015

ORIGINAL RESEARCH

Application of the new GOLD COPD staging system to a US primary care cohort, with comparison to physician and patient impressions of severity Mapel DW, Dalal AA, Johnson PJ, Becker LK, Hunter AG International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1477-1486 Published Date: 29 July 2015

REVIEW

Clinical characteristics of patients with chronic obstructive pulmonary disease with comorbid bronchiectasis: a systemic review and meta-analysis Ni Y, Shi G, Yu Y, Hao J, Chen T, Song H International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1465-1475 Published Date: 28 July 2015

ORIGINAL RESEARCH

Variants in multiple genes polymorphism association analysis of COPD in the Chinese Li population Ding Y, Yang D, Zhou L, Xu J, Chen Y, He P, Yao J, Chen J, Niu H, Sun P, Jin T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1455-1463 Published Date: 27 July 2015

REVIEW

Clinical characteristics of the asthma–COPD overlap syndrome – a systematic review Nielsen M, Bårnes CB, Ulrik CS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1443-1454 Published Date: 27 July 2015

REVIEW

Positioning new pharmacotherapies for COPD Barjaktarevic IZ, Arredondo AF, Cooper CB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1427-1442 Published Date: 24 July 2015

ORIGINAL RESEARCH

Validation of an administrative claims-based diagnostic code for pneumonia in a US-based commercially insured COPD population Kern DM, Davis J, Williams SA, Tunceli O, Wu B, Hollis S, Strange C, Trudo F International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1417-1425 Published Date: 23 July 2015

ORIGINAL RESEARCH

Smoking duration, respiratory symptoms, and COPD in adults aged ≥45 years with a smoking history Liu Y, Pleasants RA, Croft JB, Wheaton AG, Heidari K, Malarcher AM, Ohar JA, Kraft M, Mannino DM, Strange C International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1409-1416 Published Date: 21 July 2015

ORIGINAL RESEARCH

Is dynamometry able to infer the risk of muscle mass loss in patients with COPD? Ramos D, Bertolini GN, Leite MR, Carvalho Junior LCS, da Silva Pestana PR, Santos VR, Fortaleza ACS, Rodrigues FMM, Ramos EMC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1403-1407 Published Date: 21 July 2015

ORIGINAL RESEARCH

Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD Holz O, Roepcke S, Watz H, Tegtbur U, Lahu G, Hohlfeld JM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1393-1402 Published Date: 21 July 2015

REVIEW

Clinical role of dual bronchodilation with an indacaterol–glycopyrronium combination in the management of COPD: its impact on patient-related outcomes and quality of life Rossi A, Zanardi E, Poletti V, Cazzola M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1383-1392 Published Date: 23 July 2015

ORIGINAL RESEARCH

Characteristics of prevalent and new COPD cases in Greece: the GOLDEN study Mitsiki E, Bania E, Varounis C, Gourgoulianis KI, Alexopoulos EC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1371-1382 Published Date: 20 July 2015

ORIGINAL RESEARCH

Self-reported alcohol intake and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study Wetherbee EE, Niewoehner DE, Sisson JH, Lindberg SM, Connett JE, Kunisaki KM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1363-1370 Published Date: 20 July 2015

ORIGINAL RESEARCH

Underdiagnosis and prognosis of chronic obstructive pulmonary disease after percutaneous coronary intervention: a prospective study Almagro P, Lapuente A, Pareja J, Yun S, Garcia ME, Padilla F, Heredia JL, De la Sierra A, Soriano JB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1353-1361 Published Date: 16 July 2015

ORIGINAL RESEARCH

Clinical significance of laryngopharyngeal reflux in patients with chronic obstructive pulmonary disease Jung YH, Lee DY, Kim DW, Park SS, Heo EY, Chung HS, Kim DK International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1343-1351 Published Date: 15 July 2015

REVIEW

Underrecognized comorbidities of chronic obstructive pulmonary disease Miłkowska-Dymanowska J, Białas AJ, Zalewska-Janowska A, Górski P, Piotrowski WJ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1331-1341 Published Date: 15 July 2015

ORIGINAL RESEARCH

What pulmonologists think about the asthma–COPD overlap syndrome Miravitlles M, Alcázar B, Alvarez FJ, Bazús T, Calle M, Casanova C, Cisneros C, de-Torres JP, Entrenas LM, Esteban C, García-Sidro P, Cosio BG, Huerta A, Iriberri M, Izquierdo JL, López-Viña A, López-Campos JL, MartínezMoragón E, Pérez de Llano L, Perpiñá M, Ros JA, Serrano J, Soler-Cataluña JJ, Torrego A, Urrutia I, Plaza V International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1321-1330 Published Date: 15 July 2015

ORIGINAL RESEARCH

Pulmonary hemodynamic profile in chronic obstructive pulmonary disease Portillo K, Torralba Y, Blanco I, Burgos F, Rodriguez-Roisin R, Rios J, Roca J, Barberà JA International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1313-1320 Published Date: 14 July 2015

ORIGINAL RESEARCH

The inspiratory capacity/total lung capacity ratio as a predictor of survival in an emphysematous phenotype of chronic obstructive pulmonary disease French A, Balfe D, Mirocha JM, Falk JA, Mosenifar Z International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1305-1312 Published Date: 13 July 2015

CASE REPORT

Pathological and radiological correlation in an autopsy case of combined pulmonary fibrosis and emphysema Karata H, Tanaka T, Egashira R, Tabata K, Otani K, Hayashi R, Hori T, Fukuoka J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1299-1303 Published Date: 8 July 2015

ORIGINAL RESEARCH

Evaluating inhaler use technique in COPD patients Pothirat C, Chaiwong W, Phetsuk N, Pisalthanapuna S, Chetsadaphan N, Choomuang W International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1291-1298 Published Date: 8 July 2015

ORIGINAL RESEARCH

Prevalence of chronic kidney diseases in patients with chronic obstructive pulmonary disease: assessment based on glomerular filtration rate estimated from creatinine and cystatin C levels Yoshizawa T, Okada K, Furuichi S, Ishiguro T, Yoshizawa A, Akahoshi T, Gon Y, Akashiba T, Hosokawa Y, Hashimoto S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1283-1289 Published Date: 6 July 2015

ORIGINAL RESEARCH

Effects of pharmacologic treatment based on airflow limitation and breathlessness on daily physical activity in patients with chronic obstructive pulmonary disease Minakata Y, Morishita Y, Ichikawa T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Ichinose M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1275-1282 Published Date: 3 July 2015

ORIGINAL RESEARCH

Prediction of short term re-exacerbation in patients with acute exacerbation of chronic obstructive pulmonary disease Liu D, Peng SH, Zhang J, Bai SH, Liu HX, Qu JM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1265-1273 Published Date: 2 July 2015

ORIGINAL RESEARCH

Systemic signs of neutrophil mobilization during clinically stable periods and during exacerbations in smokers with obstructive pulmonary disease Andelid K, Andersson A, Yoshihara S, Åhrén C, Jirholt P, Ekberg-Jansson A, Lindén A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1253-1263 Published Date: 30 June 2015

ORIGINAL RESEARCH

Identification of genetic variants in the TNF promoter associated with COPD secondary to tobacco smoking and its severity Reséndiz-Hernández JM, Sansores RH, Hernández-Zenteno RJ, Vargas-Alarcón G, Colín-Barenque L, VelázquezUncal M, Camarena A, Ramírez-Venegas A, Falfán-Valencia R International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1241-1251 Published Date: 29 June 2015

REVIEW

Postural control in chronic obstructive pulmonary disease: a systematic review Porto EF, Castro AAM, Schmidt VGS, Rabelo HM, Kümpel C, Nascimento OA, Jardim JR International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1233-1239 Published Date: 29 June 2015

REVIEW

Improving outcomes in chronic obstructive pulmonary disease: the role of the interprofessional approach Amalakuhan B, Adams SG International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1225-1232 Published Date: 26 June 2015

ORIGINAL RESEARCH

COPD in patients with stable heart failure in the primary care setting Valk MJ, Broekhuizen BD, Mosterd A, Zuithoff NP, Hoes AW, Rutten FH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1219-1224 Published Date: 26 June 2015

ORIGINAL RESEARCH

Peak expiratory flow rate as a surrogate for forced expiratory volume in 1 second in COPD severity classification in Thailand Pothirat C, Chaiwong W, Phetsuk N, Liwsrisakun C, Bumroongkit C, Deesomchok A, Theerakittikul T, Limsukon A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1213-1218 Published Date: 25 June 2015

ORIGINAL RESEARCH

Relationship between nutritional risk and exercise capacity in severe chronic obstructive pulmonary disease in male patients Shan XZ, Liu JM, Luo YR, Xu XW, Han ZQ, Li HL International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1207-1212 Published Date: 23 June 2015

ORIGINAL RESEARCH

Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document Suzuki T, Tada Y, Kawata N, Ikari J, Kasahara Y, Sakurai Y, Iesato K, Nishimura R, West J, Tatsumi K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1199-1205 Published Date: 19 June 2015

ORIGINAL RESEARCH

Small airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease Pisi R, Aiello M, Zanini A, Tzani P, Paleari D, Marangio E, Spanevello A, Nicolini G, Chetta A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1191-1197 Published Date: 19 June 2015

REVIEW

Profile of a fixed-dose combination of tiotropium/olodaterol and its potential in the treatment of COPD Muruganandan S, Jayaram L International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1179-1189 Published Date: 18 June 2015

ORIGINAL RESEARCH

Impact of direct substitution of arm span length for current standing height in elderly COPD Pothirat C, Chaiwong W, Phetsuk N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1173-1178 Published Date: 22 June 2015

ORIGINAL RESEARCH

Test-retest reliability of lower limb isokinetic endurance in COPD: a comparison of angular velocities Ribeiro F, Lépine PA, Garceau-Bolduc C, Coats V, Allard E, Maltais F, Saey D International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1163-1172 Published Date: 18 June 2015

ORIGINAL RESEARCH

Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease Zanini A, Cherubino F, Zampogna E, Croce S, Pignatti P, Spanevello A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1155-1161 Published Date: 17 June 2015

ORIGINAL RESEARCH

Severe hypoalbuminemia is a strong independent risk factor for acute respiratory failure in COPD: a nationwide cohort study Chen CW, Chen YY, Lu CL, Chen SC, Chen YJ, Lin MS, Chen W International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1147-1154 Published Date: 17 June 2015

ORIGINAL RESEARCH

Effects of indacaterol versus tiotropium on respiratory mechanics assessed by the forced oscillation technique in patients with chronic obstructive pulmonary disease Inui N, Matsushima S, Kato S, Yasui H, Kono M, Fujisawa T, Enomoto N, Nakamura Y, Toyoshima M, Suda T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1139-1146 Published Date: 17 June 2015

ORIGINAL RESEARCH

Predicting energy requirement with pedometer-determined physical-activity level in women with chronic obstructive pulmonary disease Farooqi N, Slinde F, Carlsson M, Håglin L, Sandström T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1129-1137 Published Date: 15 June 2015

ORIGINAL RESEARCH

Roflumilast, a phosphodiesterase-4 inhibitor, induces phagocytic activity in Greek COPD patients Porpodis K, Domvri K, Zarogoulidis P, Petridis D, Tsirgogianni K, Papaioannou A, Hatzizisi O, Kioumis I, Liaka A, Kikidaki V, Lampaki S, Organtzis J, Zarogoulidis K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1123-1128 Published Date: 15 June 2015

REVIEW

The health burden of pollution: the impact of prenatal exposure to air pollutants Vieira SE International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1111-1121 Published Date: 10 June 2015

ORIGINAL RESEARCH

Comprehensive analysis of gene-expression profile in chronic obstructive pulmonary disease Wei L, Xu D, Qian YC, Huang GY, Ma W, Liu FY, Shen YH, Wang ZF, Li L, Zhang SF, Chen YF International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1103-1109 Published Date: 10 June 2015

REVIEW

LAMA/LABA vs ICS/LABA in the treatment of COPD in Japan based on the disease phenotypes Hizawa N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1093-1102 Published Date: 10 June 2015

ORIGINAL RESEARCH

Screening of COPD patients for abdominal aortic aneurysm Flessenkaemper IH, Loddenkemper R, Roll S, Enke-Melzer K, Wurps H, Bauer TT International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1085-1091 Published Date: 10 June 2015

ORIGINAL RESEARCH

Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function Bafadhel M, Haldar K, Barker B, Patel H, Mistry V, Barer MR, Pavord ID, Brightling CE International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1075-1083 Published Date: 9 June 2015

ORIGINAL RESEARCH

A randomized controlled trial evaluating the effectiveness of a web-based, computer-tailored self-management intervention for people with or at risk for COPD Voncken-Brewster V, Tange H, de Vries H, Nagykaldi Z, Winkens B, van der Weijden T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1061-1073 Published Date: 8 June 2015

ORIGINAL RESEARCH

The reasons for triple therapy in stable COPD patients in Japanese clinical practice Miyazaki M, Nakamura H, Takahashi S, Chubachi S, Sasaki M, Haraguchi M, Terai H, Ishii M, Fukunaga K, Tasaka S, Soejima K, Asano K, Betsuyaku T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1053-1059 Published Date: 4 June 2015

ORIGINAL RESEARCH

Important, misunderstood, and challenging: a qualitative study of nurses’ and allied health professionals’ perceptions of implementing self-management for patients with COPD Young HML, Apps LD, Harrison SL, Johnson-Warrington VL, Hudson N, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1043-1052 Published Date: 3 June 2015

ORIGINAL RESEARCH

A comparative study of COPD burden between urban vs rural communities in northern Thailand Pothirat C, Chaiwong W, Phetsuk N, Pisalthanapuna S, Chetsadaphan N, Inchai J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1035-1042 Published Date: 2 June 2015

ORIGINAL RESEARCH

Lobe-based computed tomography assessment of airway diameter, airway or vessel number, and emphysema extent in relation to the clinical outcomes of COPD Kurashima K, Takaku Y, Hoshi T, Kanauchi T, Nakamoto K, Takayanagi N, Yanagisawa T, Sugita Y, Kawabata Y International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1027-1033 Published Date: 2 June 2015

ORIGINAL RESEARCH

LANTERN: a randomized study of QVA149 versus salmeterol/fluticasone combination in patients with COPD Zhong N, Wang C, Zhou X, Zhang N, Humphries M, Wang L, Thach C, Patalano F, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1015-1026 Published Date: 5 June 2015

REVIEW

Novel aspects of pathogenesis and regeneration mechanisms in COPD Bagdonas E, Raudoniute J, Bruzauskaite I, Aldonyte R International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:995-1013 Published Date: 2 June 2015

ORIGINAL RESEARCH

Prognostic factors for clinical failure of exacerbations in elderly outpatients with moderate-tosevere COPD Wilson R, Anzueto A, Miravitlles M, Arvis P, Haverstock D, Trajanovic M, Sethi S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:985-993 Published Date: 2 June 2015

ORIGINAL RESEARCH

Evaluation of the COPD Assessment Test and GOLD patient types: a cross-sectional analysis Lopez-Campos JL, Fernandez-Villar A, Calero-Acuña C, Represas-Represas C, Lopez-Ramírez C, Fernández VL, Soler-Cataluña JJ, Casamor R International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:975-984 Published Date: 27 May 2015

ORIGINAL RESEARCH

Acute vasoreactivity test results in severe pulmonary hypertension patients with chronic obstructive pulmonary disease: our experience with 29 cases Asker S, Asker M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:969-973 Published Date: 28 May 2015

ORIGINAL RESEARCH

Factors associated with inadequate diagnosis of COPD: On-Sint cohort analysis Fernández-Villar A, López-Campos JL, Represas Represas C, Marín Barrera L, Leiro Fernández V, López Ramírez C, Casamor R International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:961-967 Published Date: 18 May 2015

ORIGINAL RESEARCH

Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease Chun EM, Kim SW, Lim SY International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:955-960 Published Date: 18 May 2015

ORIGINAL RESEARCH

Clinical, physiological, and radiological features of asthma–chronic obstructive pulmonary disease overlap syndrome Suzuki T, Tada Y, Kawata N, Matsuura Y, Ikari J, Kasahara Y, Tatsumi K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:947-954 Published Date: 15 May 2015

ORIGINAL RESEARCH

Expiratory flow limitation relates to symptoms during COPD exacerbations requiring hospital admission Jetmalani K, Timmins S, Brown NJ, Diba C, Berend N, Salome CM, Wen FQ, Chen P, King GG, Farah CS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:939-945 Published Date: 14 May 2015

ORIGINAL RESEARCH

Epidemiology, severity, and treatment of chronic obstructive pulmonary disease in the United Kingdom by GOLD 2013 Raluy-Callado M, Lambrelli D, MacLachlan S, Khalid JM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:925-937 Published Date: 13 May 2015

ORIGINAL RESEARCH

Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes Zhang JQ, Zhang JQ, Liu H, Zhao ZH, Fang LZ, Liu L, Fu WP, Shu JK, Feng JG, Dai LM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:917-923 Published Date: 13 May 2015

ORIGINAL RESEARCH

Lower 30-day readmission rates with roflumilast treatment among patients hospitalized for chronic obstructive pulmonary disease Fu AZ, Sun SX, Huang X, Amin AN International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:909-915 Published Date: 12 May 2015

ORIGINAL RESEARCH

Seasonality, ambient temperatures and hospitalizations for acute exacerbation of COPD: a population-based study in a metropolitan area Almagro P, Hernandez C, Martinez-Cambor P, Tresserras R, Escarrabill J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:899-908 Published Date: 8 May 2015

CASE REPORT

Identification of a novel SERPINA-1 mutation causing alpha-1 antitrypsin deficiency in a patient with severe bronchiectasis and pulmonary embolism Milger K, Holdt LM, Teupser D, Huber RM, Behr J, Kneidinger N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:891-897 Published Date: 7 May 2015

ORIGINAL RESEARCH

Patients with chronic obstructive pulmonary disease and chronically colonized with Haemophilus influenzae during stable disease phase have increased airway inflammation Tufvesson E, Bjermer L, Ekberg M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:881-889 Published Date: 4 May 2015

ORIGINAL RESEARCH

The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease Kim YW, Jin KN, Heo EY, Park SS, Chung HS, Kim DK International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:873-879 Published Date: 4 May 2015

LETTER

Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis Sangani RG, Ghio AJ, Parker JE International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:869-871 Published Date: 2 May 2015

ORIGINAL RESEARCH

Supported self-management for patients with COPD who have recently been discharged from hospital: a systematic review and meta-analysis Majothi S, Jolly K, Heneghan NR, Price MJ, Riley RD, Turner AM, Bayliss SE, Moore DJ, Singh SJ, Adab P, Fitzmaurice DA, Jordan RE International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:853-867 Published Date: 29 April 2015

ORIGINAL RESEARCH

Is intrathoracic tracheal collapsibility correlated to clinical phenotypes and sex in patients with COPD? Camiciottoli G, Diciotti S, Bigazzi F, Lombardo S, Bartolucci M, Paoletti M, Mascalchi M, Pistolesi M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:843-852 Published Date: 28 April 2015

ORIGINAL RESEARCH

Inter-alpha-trypsin inhibitor heavy chain 4: a novel biomarker for environmental exposure to particulate air pollution in patients with chronic obstructive pulmonary disease Lee KY, Feng PH, Ho SC, Chuang KJ, Chen TT, Su CL, Liu WT, Chuang HC International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:831-841 Published Date: 24 April 2015

ORIGINAL RESEARCH

Do females behave differently in COPD exacerbation? Kilic H, Kokturk N, Sari G, Cakir M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:823-830 Published Date: 24 April 2015

REVIEW

Role of combined indacaterol and glycopyrronium bromide (QVA149) for the treatment of COPD in Japan Horita N, Kaneko T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:813-822 Published Date: 21 April 2015

ORIGINAL RESEARCH

Anti-inflammatory effects of salmeterol/fluticasone propionate 50/250 mcg combination therapy in Japanese patients with chronic obstructive pulmonary disease Asai K, Kobayashi A, Makihara Y, Johnson M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:803-811 Published Date: 17 April 2015

REVIEW

Effectiveness of pulmonary rehabilitation in COPD with mild symptoms: a systematic review with meta-analyses Rugbjerg M, Iepsen UW, Jørgensen KJ, Lange P International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:791-801 Published Date: 17 April 2015

REVIEW

Role of the fixed combination of fluticasone and salmeterol in adult Chinese patients with asthma and COPD Gao J, Pleasants RA International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:775-789 Published Date: 15 April 2015

ORIGINAL RESEARCH

Procalcitonin and C-reactive protein cannot differentiate bacterial or viral infection in COPD exacerbation requiring emergency department visits Chang CH, Tsao KC, Hu HC, Huang CC, Kao KC, Chen NH, Yang CT, Tsai YH, Hsieh MJ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:767-774 Published Date: 13 April 2015

ORIGINAL RESEARCH

Comparative study on health care utilization and hospital outcomes of severe acute exacerbation of chronic obstructive pulmonary disease managed by pulmonologists vs internists Pothirat C, Liwsrisakun C, Bumroongkit C, Deesomchok A, Theerakittikul T, Limsukon A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:759-766 Published Date: 13 April 2015

ORIGINAL RESEARCH

Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients Nagai K, Makita H, Suzuki M, Shimizu K, Konno S, Ito YM, Nishimura M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:745-757 Published Date: 10 April 2015

REVIEW

Patient preferences in severe COPD and asthma: a comprehensive literature review Bereza BG, Troelsgaard Nielsen A, Valgardsson S, Hemels MEH, Einarson TR International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:739-744 Published Date: 8 April 2015

REVIEW

A review of the most common patient-reported outcomes in COPD – revisiting current knowledge and estimating future challenges Cazzola M, Hanania NA, MacNee W, Rüdell K, Hackford C, Tamimi N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:725-738 Published Date: 7 April 2015

ORIGINAL RESEARCH

Rosiglitazone attenuates the metalloprotease/anti-metalloprotease imbalance in emphysema induced by cigarette smoke: involvement of extracellular signal-regulated kinase and NF B signaling Hou G, Yin Y, Han D, Wang QY, Kang J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:715-724 Published Date: 7 April 2015

LETTER

Modafinil: a novel alternative to non-invasive ventilation in hypercapnic respiratory failure? Matos P, Esquinas AM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:711-713 Published Date: 1 April 2015

ORIGINAL RESEARCH

Effectiveness of bronchoscopic lung volume reduction using unilateral endobronchial valve: a systematic review and meta-analysis Choi M, Lee WS, Lee M, Jeon K, Sheen S, Jheon S, Kim YS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:703-710 Published Date: 31 March 2015

ORIGINAL RESEARCH

Systemic cytokine signaling via IL-17 in smokers with obstructive pulmonary disease: a link to bacterial colonization? Andelid K, Tengvall S, Andersson A, Levänen B, Christenson K, Jirholt P, Åhrén C, Qvarfordt I, Ekberg-Jansson A, Lindén A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:689-702 Published Date: 27 March 2015

REVIEW

Clinical potential of aclidinium bromide in chronic obstructive pulmonary disease Jones PW International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:677-687 Published Date: 26 March 2015

ORIGINAL RESEARCH

A bibliometric analysis of the 100 most influential papers on COPD Gu WC, Yuan YP, Yang H, Qi GS, Jin XY, Yan J International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:667-676 Published Date: 25 March 2015

ORIGINAL RESEARCH

COPD and its association with smoking in the Mainland China: a cross-sectional analysis of 0.5 million men and women from ten diverse areas Kurmi OP, Li L, Wang J, Millwood IY, Chen J, Collins R, Guo Y, Bian Z, Li J, Chen B, Xie K, Jia W, Gao Y, Peto R, Chen Z International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:655-665 Published Date: 20 March 2015

ORIGINAL RESEARCH

Home-based pulmonary rehabilitation improves clinical features and systemic inflammation in chronic obstructive pulmonary disease patients Nascimento ESP, Sampaio LMM, Peixoto-Souza FS, Dias FD, Gomes ELFD, Greiffo FR, Ligeiro de Oliveira AP, Stirbulov R, Vieira RP, Costa D International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:645-653 Published Date: 23 March 2015

REVIEW

Comparison of laboratory- and field-based exercise tests for COPD: a systematic review Fotheringham I, Meakin G, Punekar YS, Riley JH, Cockle SM, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:625-643 Published Date: 19 March 2015

ORIGINAL RESEARCH

Early impact of treatment with tiotropium, long-acting anticholinergic preparation, in patients with COPD – real-life experience from an observational study Jahnz-Różyk K, Szepiel P International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:613-623 Published Date: 18 March 2015

ORIGINAL RESEARCH

Length of stay of COPD hospital admissions between 2006 and 2010: a retrospective longitudinal study Harries TH, Thornton HV, Crichton S, Schofield P, Gilkes A, White PT International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:603-611 Published Date: 18 March 2015

ORIGINAL RESEARCH

Causes of death in patients with asthma and asthma–chronic obstructive pulmonary disease overlap syndrome Harada T, Yamasaki A, Fukushima T, Hashimoto K, Takata M, Kodani M, Okazaki R, Takeda K, Watanabe M, Kurai J, Shimizu E International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:595-602 Published Date: 18 March 2015

ORIGINAL RESEARCH

Elevated plasma levels of pigment epithelium-derived factor correlated with inflammation and lung function in COPD patients Li X, Wang T, Yang T, Shen Y, An J, Liu L, Dong J, Guo L, Li D, Zhang X, Chen L, Xu D, Wen F International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:587-594 Published Date: 17 March 2015

ORIGINAL RESEARCH

Impact and factors associated with nighttime and early morning symptoms among patients with chronic obstructive pulmonary disease Stephenson JJ, Cai Q, Mocarski M, Tan H, Doshi JA, Sullivan SD International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:577-586 Published Date: 17 March 2015

ORIGINAL RESEARCH

Impact of roflumilast on exacerbations of COPD, health care utilization, and costs in a predominantly elderly Medicare Advantage population Moll K, Sun SX, Ellis JJ, Howe A, Amin A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:565-576 Published Date: 16 March 2015

ORIGINAL RESEARCH

Comorbidities of patients in tiotropium clinical trials: comparison with observational studies of patients with chronic obstructive pulmonary disease Miravitlles M, Price D, Rabe KF, Schmidt H, Metzdorf N, Celli B International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:549-564 Published Date: 16 March 2015

ORIGINAL RESEARCH

Dialectal influence on chronic pulmonary disease assessment test: the reliability and validity study Pothirat C, Chaiwong W, Phetsuk N, Liwsrisakun C, Bumroongkit C, Deesomchok A, Theerakittikul T, Limsukon A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:541-548 Published Date: 11 March 2015

ORIGINAL RESEARCH

Misidentification of airflow obstruction: prevalence and clinical significance in an epidemiological study Pothirat C, Chaiwong W, Phetsuk N, Liwsrisakun C International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:535-540 Published Date: 11 March 2015

ORIGINAL RESEARCH

Do frequent moderate exacerbations contribute to progression of chronic obstructive pulmonary disease in patients who are ex-smokers? Dreyse J, Díaz O, Repetto PB, Morales A, Saldías F, Lisboa C International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:525-533 Published Date: 10 March 2015

ORIGINAL RESEARCH

Impact of -blocker selectivity on long-term outcomes in congestive heart failure patients with chronic obstructive pulmonary disease Kubota Y, Asai K, Furuse E, Nakamura S, Murai K, Tsukada YT, Shimizu W International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:515-523 Published Date: 5 March 2015

ORIGINAL RESEARCH

The COPD assessment test correlates well with the computed tomography measurements in COPD patients in China Zhang Y, Tu YH, Fei GH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:507-514 Published Date: 5 March 2015

ORIGINAL RESEARCH

Risk factors for chronic obstructive pulmonary disease among never-smokers in Korea Lee SJ, Kim SW, Kong KA, Ryu YJ, Lee JH, Chang JH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:497-506 Published Date: 5 March 2015

ORIGINAL RESEARCH

Oral and pharyngeal bolus transit in patients with chronic obstructive pulmonary disease Cassiani RA, Santos CM, Baddini-Martinez J, Dantas RO International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:489-496 Published Date: 5 March 2015

ORIGINAL RESEARCH

Evaluation of the psychometric properties of the Nighttime Symptoms of COPD Instrument Mocarski M, Zaiser E, Trundell D, Make BJ, Hareendran A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:475-487 Published Date: 6 March 2015

ORIGINAL RESEARCH

Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease Wang R, Li M, Zhou SJ, Zeng DX, Xu X, Xu R, Sun GY International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:463-473 Published Date: 4 March 2015

ORIGINAL RESEARCH

Amoxicillin concentrations in relation to beta-lactamase activity in sputum during exacerbations of chronic obstructive pulmonary disease Brusse-Keizer M, VanderValk P, van der Zanden RW, Nijdam L, van der Palen J, Hendrix R, Movig K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:455-461 Published Date: 3 March 2015

ORIGINAL RESEARCH

A pilot study: mindfulness meditation intervention in COPD Chan RR, Giardino N, Larson JL International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:445-454 Published Date: 2 March 2015

ORIGINAL RESEARCH

Influence of indacaterol on daily physical activity in patients with untreated chronic obstructive pulmonary disease Nishijima Y, Minami S, Yamamoto S, Ogata Y, Koba T, Futami S, Komuta K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:439-444 Published Date: 27 February 2015

ORIGINAL RESEARCH

The effect of comorbidities on COPD assessment: a pilot study Weinreich UM, Thomsen LP, Bielaska B, Jensen VH, Vuust M, Rees SE International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:429-438 Published Date: 25 February 2015

ORIGINAL RESEARCH

Functional capacity, physical activity, and quality of life in hypoxemic patients with chronic obstructive pulmonary disease Saglam M, Vardar-Yagli N, Savci S, Inal-Ince D, Calik-Kutukcu E, Arikan H, Coplu L International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:423-428 Published Date: 26 February 2015

ORIGINAL RESEARCH

Treatment patterns of chronic obstructive pulmonary disease in employed adults in the United States Diette GB, Dalal AA, D’Souza AO, Lunacsek OE, Nagar SP International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:415-422 Published Date: 24 February 2015

ORIGINAL RESEARCH

Detection of COPD in a high-risk population: should the diagnostic work-up include bronchodilator reversibility testing? Kjeldgaard P, Dahl R, Løkke A, Ulrik CS International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:407-414 Published Date: 23 February 2015

ORIGINAL RESEARCH

Exhaled volatile organic compounds discriminate patients with chronic obstructive pulmonary disease from healthy subjects Besa V, Teschler H, Kurth I, Khan AM, Zarogoulidis P, Baumbach JI, Sommerwerck U, Freitag L, Darwiche K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:399-406 Published Date: 23 February 2015

ORIGINAL RESEARCH

Self-reported sleep quality and acute exacerbations of chronic obstructive pulmonary disease Geiger-Brown J, Lindberg S, Krachman S, McEvoy CE, Criner GJ, Connett JE, Albert RK, Scharf SM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:389-397 Published Date: 20 February 2015

ORIGINAL RESEARCH

Antibiotics against Pseudomonas aeruginosa for COPD exacerbation in ICU: a 10-year retrospective study Planquette B, Péron J, Dubuisson E, Roujansky A, Laurent V, Le Monnier A, Legriel S, Ferre A, Bruneel F, Chiles PG, Bedos JP International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:379-388 Published Date: 17 February 2015

ORIGINAL RESEARCH

Clinical variables impacting on the estimation of utilities in chronic obstructive pulmonary disease Miravitlles M, Huerta A, Valle M, García-Sidro P, Forné C, Crespo C, López-Campos JL International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:367-377 Published Date: 16 February 2015

ORIGINAL RESEARCH

Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD Gumus A, Altintas N, Cinarka H, Kirbas A, Hazıroglu M, Karatas M, Sahin U International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:357-365 Published Date: 13 February 2015

ORIGINAL RESEARCH

Caregivers’ burden in patients with COPD Miravitlles M, Peña-Longobardo LM, Oliva-Moreno J, Hidalgo-Vega Á International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:347-356 Published Date: 12 February 2015

ORIGINAL RESEARCH

Heart rate and blood pressure responses during hypoxic cycles of a 3-week intermittent hypoxia breathing program in patients at risk for or with mild COPD Faulhaber M, Gatterer H, Haider T, Linser T, Netzer N, Burtscher M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:339-345 Published Date: 11 February 2015

ORIGINAL RESEARCH

Cardiovascular and respiratory dysfunction in chronic obstructive pulmonary disease complicated by impaired peripheral oxygenation Chuang ML, Huang SF, Su CH International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:329-337 Published Date: 11 February 2015

ORIGINAL RESEARCH

Iterative reconstruction for quantitative computed tomography analysis of emphysema: consistent results using different tube currents Yamashiro T, Miyara T, Honda O, Tomiyama N, Ohno Y, Noma S, Murayama S, ACTIve Study Group International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:321-327 Published Date: 11 February 2015

ORIGINAL RESEARCH

Relationship between serum cardiac troponin T level and cardiopulmonary function in stable chronic obstructive pulmonary disease Hattori K, Ishii T, Motegi T, Kusunoki Y, Gemma A, Kida K International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:309-320 Published Date: 10 February 2015

REVIEW

Systematic literature review of patient-reported outcome measures used in assessment and measurement of sleep disorders in chronic obstructive pulmonary disease Garrow AP, Yorke J, Khan N, Vestbo J, Singh D, Tyson S International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:293-307 Published Date: 9 February 2015

ORIGINAL RESEARCH

Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD Khorasani N, Baker J, Johnson M, Chung KF, Bhavsar PK International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:283-291 Published Date: 4 February 2015

ORIGINAL RESEARCH

Detection of acute deterioration in health status visit among COPD patients by monitoring COPD assessment test score Pothirat C, Chaiwong W, Limsukon A, Deesomchok A, Liwsrisakun C, Bumroongkit C, Theerakittikul T, Phetsuk N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:277-282 Published Date: 3 February 2015

REVIEW

COPD: balancing oxidants and antioxidants Fischer BM, Voynow JA, Ghio AJ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:261-276 Published Date: 2 February 2015

ORIGINAL RESEARCH

Tiotropium HandiHaler® and Respimat® in COPD: a pooled safety analysis Halpin DMG, Dahl R, Hallmann C, Mueller A, Tashkin D International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:239-259 Published Date: 5 February 2015

ORIGINAL RESEARCH

Associated bone mineral density and obstructive sleep apnea in chronic obstructive pulmonary disease Wang TY, Lo YL, Chou PC, Chung FT, Lin SM, Lin TY, Lin HC, Wang CH, Yu CT, Kuo HP International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:231-237 Published Date: 29 January 2015

ORIGINAL RESEARCH

Analysis of autonomic modulation after an acute session of resistance exercise at different intensities in chronic obstructive pulmonary disease patients Nicolino J, Ramos D, Leite MR, Rodrigues FM, Silva BS, Tacao GY, Toledo AC, Vanderlei LC, Ramos EM International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:223-229 Published Date: 29 January 2015

ORIGINAL RESEARCH

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial John ME, Cockcroft JR, McKeever TM, Coward WR, Shale DJ, Johnson SR, Thornton JG, Harrison TW, Knox AJ, Bolton CE International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:211-221 Published Date: 29 January 2015

ORIGINAL RESEARCH

A score to predict short-term risk of COPD exacerbations (SCOPEX) Make BJ, Eriksson G, Calverley PM, Jenkins CR, Postma DS, Peterson S, Östlund O, Anzueto A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:201-209 Published Date: 27 January 2015

ORIGINAL RESEARCH

Analysis of diaphragmatic movement before and after pulmonary rehabilitation using fluoroscopy imaging in patients with COPD Chun EM, Han SJ, Modi HN International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:193-199 Published Date: 27 January 2015

ORIGINAL RESEARCH

Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls Ishikawa N, Hattori N, Kohno N, Kobayashi A, Hayamizu T, Johnson M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:185-192 Published Date: 23 January 2015

ORIGINAL RESEARCH

Comorbidity and health-related quality of life in patients with severe chronic obstructive pulmonary disease attending Swedish secondary care units Sundh J, Johansson G, Larsson K, Lindén A, Löfdahl CG, Janson C, Sandström T International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:173-183 Published Date: 22 January 2015

ORIGINAL RESEARCH

Continuing to Confront COPD International Surveys: comparison of patient and physician perceptions about COPD risk and management Menezes AM, Landis SH, Han MK, Muellerova H, Aisanov Z, van der Molen T, Oh YM, Ichinose M, Mannino DM, Davis KJ International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:159-172 Published Date: 20 January 2015

ORIGINAL RESEARCH

Dynamic hyperinflation and dyspnea during the 6-minute walk test in stable chronic obstructive pulmonary disease patients Satake M, Shioya T, Uemura S, Takahashi H, Sugawara K, Kasai C, Kiyokawa N, Watanabe T, Sato S, Kawagoshi A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:153-158 Published Date: 17 January 2015

ORIGINAL RESEARCH

EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population Ding YP, Niu H, Yang H, Sun P, Chen Y, Duan ML, Xu DC, Xu JX, Jin TB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:145-151 Published Date: 13 January 2015

ORIGINAL RESEARCH

Long-term efficacy of intensive cycle ergometer exercise training program for advanced COPD patients Pothirat C, Chaiwong W, Phetsuk N, Liwsrisakun C, Bumroongkit C, Deesomchok A, Theerakittikul T, Limsukon A International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:133-144 Published Date: 12 January 2015

ORIGINAL RESEARCH

Whole-body vibration improves functional capacity and quality of life in patients with severe chronic obstructive pulmonary disease (COPD): a pilot study Braz Júnior DS, Dornelas de Andrade A, Teixeira AS, Cavalcanti CA, Morais AB, Marinho PE International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:125-132 Published Date: 12 January 2015

REVIEW

Profile of inhaled glycopyrronium bromide as monotherapy and in fixed-dose combination with indacaterol maleate for the treatment of COPD Prakash A, Babu KS, Morjaria JB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:111-123 Published Date: 7 January 2015

REVIEW

Managing comorbidities in COPD Hillas G, Perlikos F, Tsiligianni I, Tzanakis N International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:95-109 Published Date: 7 January 2015

ORIGINAL RESEARCH

Symptoms and impact of COPD assessed by an electronic diary in patients with moderate-tosevere COPD: psychometric results from the SHINE study Kulich K, Keininger DL, Tiplady B, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:79-94 Published Date: 7 January 2015

ORIGINAL RESEARCH

Questionnaire on switching from the tiotropium HandiHaler to the Respimat inhaler in patients with chronic obstructive pulmonary disease: changes in handling and preferences immediately and several years after the switch Hanada S, Wada S, Ohno T, Sawaguchi H, Muraki M, Tohda Y International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:69-77 Published Date: 6 January 2015

ORIGINAL RESEARCH

Efficacy and safety of once-daily glycopyrronium in predominantly Chinese patients with moderate-to-severe chronic obstructive pulmonary disease: the GLOW7 study Wang C, Sun T, Huang Y, Humphries M, Bai L, Li L, Wang Q, Kho P, Firth R, D’Andrea P International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:57-68 Published Date: 5 January 2015

ORIGINAL RESEARCH

Continuing to Confront COPD International Physician Survey: physician knowledge and application of COPD management guidelines in 12 countries Davis KJ, Landis SH, Oh YM, Mannino DM, Han MK, van der Molen T, Aisanov Z, Menezes AM, Ichinose M, Muellerova H International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:39-55 Published Date: 30 December 2014

ORIGINAL RESEARCH

Smoking-associated fibrosis and pulmonary asbestosis Bledsoe JR, Christiani DC, Kradin RL International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:31-37 Published Date: 19 December 2014

ORIGINAL RESEARCH

The added value of hybrid ventilation/perfusion SPECT/CT in patients with stable COPD or apparently healthy smokers. Cancer-suspected CT findings in the lungs are common when hybrid imaging is used Jögi J, Markstad H, Tufvesson E, Bjermer L, Bajc M International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:25-30 Published Date: 18 December 2014

ORIGINAL RESEARCH

Effect of severe renal impairment on umeclidinium and umeclidinium/vilanterol pharmacokinetics and safety: a single-blind, nonrandomized study Mehta R, Hardes K, Brealey N, Tombs L, Preece A, Kelleher D International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:15-23 Published Date: 18 December 2014

ORIGINAL RESEARCH

Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Hainan population: a case-control study Ding YP, Yang DL, Xun XJ, Wang ZF, Sun P, Xu DC, He P, Niu H, Jin TB International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:7-13 Published Date: 17 December 2014

ORIGINAL RESEARCH

Knowledge about COPD among users of primary health care services Queiroz MC, Moreira MA, Jardim JR, Barbosa MA, Minamisava R, Gondim HD, Velasco FC, Penhavel MV International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1-6 Published Date: 17 December 2014

PERSPECTIVES

The concept of control of COPD in clinical practice Soler-Cataluña JJ, Alcázar-Navarrete B, Miravitlles M International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1397-1405 Published Date: 12 December 2014

REVIEW

The clinical use of regenerative therapy in COPD Lipsi R, Rogliani P, Calzetta L, Segreti A, Cazzola M International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1389-1396 Published Date: 12 December 2014

REVIEW

Use of time in people with chronic obstructive pulmonary disease – a systematic review Hunt T, Madigan S, Williams MT, Olds TS International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1377-1388 Published Date: 12 December 2014

ORIGINAL RESEARCH

Ease-of-use preference for the ELLIPTA® dry powder inhaler over a commonly used single-dose capsule dry powder inhaler by inhalation device-naïve Japanese volunteers aged 40 years or older Komase Y, Asako A, Kobayashi A, Sharma R International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1365-1375 Published Date: 11 December 2014

PERSPECTIVES

The relationship between the COPD Assessment Test score and airflow limitation in Japan in patients aged over 40 years with a smoking history Yoshimoto D, Nakano Y, Onishi K, Hagan G, Jones P International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1357-1363 Published Date: 9 December 2014

ORIGINAL RESEARCH

Lobar analysis of collapsibility indices to assess functional lung volumes in COPD patients Kitano M, Iwano S, Hashimoto N, Matsuo K, Hasegawa Y, Naganawa S International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1347-1356 Published Date: 9 December 2014

ORIGINAL RESEARCH

Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan Yamauchi Y, Hasegawa W, Yasunaga H, Sunohara M, Jo T, Takami K, Matsui H, Fushimi K, Nagase T International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1337-1346 Published Date: 9 December 2014

LETTER

Systematic review comparing LABA, olodaterol, and indacaterol: limitations Donohue JF International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1331-1335 Published Date: 5 December 2014

ORIGINAL RESEARCH

Prevalence and correlates of suicide ideation in patients with COPD: a mixed methods study Fleehart S, Fan VS, Nguyen HQ, Lee J, Kohen R, Herting JR, Matute-Bello G, Adams SG, Pagalilauan G, Borson S International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1321-1329 Published Date: 4 December 2014

REVIEW

Gait speed as a measure of functional status in COPD patients Karpman C, Benzo R International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1315-1320 Published Date: 21 November 2014

ORIGINAL RESEARCH

Comorbidity in chronic obstructive pulmonary disease. Related to disease severity? Echave-Sustaeta JM, Comeche Casanova L, Cosio BG, Soler-Cataluña JJ, Garcia-Luján R, Ribera X International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1307-1314 Published Date: 19 November 2014

REVIEW

Overview of the prevalence, impact, and management of depression and anxiety in chronic obstructive pulmonary disease Panagioti M, Scott C, Blakemore A, Coventry PA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1289-1306 Published Date: 13 November 2014

REVIEW

Time to adapt exercise training regimens in pulmonary rehabilitation – a review of the literature Lee AL, Holland AE International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1275-1288 Published Date: 10 November 2014

ORIGINAL RESEARCH

Czech multicenter research database of severe COPD Novotna B, Koblizek V, Zatloukal J, Plutinsky M, Hejduk K, Zbozinkova Z, Jarkovsky J, Sobotik O, Dvorak T, Safranek P International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1265-1274 Published Date: 10 November 2014

REVIEW

Effects of Tai Chi on exercise capacity and health-related quality of life in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis Wu W, Liu X, Wang L, Wang Z, Hu J, Yan J International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1253-1263 Published Date: 7 November 2014

REVIEW

Oxygen therapy in acute exacerbations of chronic obstructive pulmonary disease Brill SE, Wedzicha JA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1241-1252 Published Date: 7 November 2014

ORIGINAL RESEARCH

Application of a new parameter in the 6-minute walk test for manifold analysis of exercise capacity in patients with COPD Ijiri N, Kanazawa H, Yoshikawa T, Hirata K International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1235-1240 Published Date: 3 November 2014

ORIGINAL RESEARCH

Low FEV1, smoking history, and obesity are factors associated with oxygen saturation decrease in an adult population cohort Vold ML, Aasebø U, Melbye H International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1225-1233 Published Date: 21 October 2014

REVIEW

Oxidative stress and free radicals in COPD – implications and relevance for treatment Domej W, Oettl K, Renner W International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1207-1224 Published Date: 17 October 2014

REVIEW

Optimizing nonpharmacological management following an acute exacerbation of chronic obstructive pulmonary disease Harrison SL, Goldstein R, Desveaux L, Tulloch V, Brooks D International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1197-1205 Published Date: 29 October 2014

ORIGINAL RESEARCH

How do COPD comorbidities affect ICU outcomes? Ongel EA, Karakurt Z, Salturk C, Takir HB, Burunsuzoglu B, Kargin F, Ekinci GH, Mocin O, Gungor G, Adiguzel N, Yilmaz A International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1187-1196 Published Date: 17 October 2014

ORIGINAL RESEARCH

Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD Postma DS, Roche N, Colice G, Israel E, Martin RJ, van Aalderen WMC, Grigg J, Burden A, Hillyer EV, von Ziegenweidt J, Gopalan G, Price D International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1163-1186 Published Date: 17 October 2014

ORIGINAL RESEARCH

Characteristics of undiagnosed COPD in a senior community center Santos SR, Lizzi ES, Vianna EO International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1155-1161 Published Date: 15 October 2014

REVIEW

Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes Aryal S, Diaz-Guzman E, Mannino DM International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1145-1154 Published Date: 14 October 2014

ORIGINAL RESEARCH

Efficacy and safety of combining olodaterol Respimat® and tiotropium HandiHaler® in patients with COPD: results of two randomized, double-blind, active-controlled studies ZuWallack R, Allen L, Hernandez G, Ting N, Abrahams R International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1133-1144 Published Date: 14 October 2014

REVIEW

Lower airway colonization and inflammatory response in COPD: a focus on Haemophilus influenzae Finney LJ, Ritchie A, Pollard E, Johnston SL, Mallia P International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1119-1132 Published Date: 13 October 2014

ORIGINAL RESEARCH

The prevalence of obstructive sleep apnea-hypopnea syndrome-related symptoms and their relation to airflow limitation in an elderly population receiving home care Kleisiaris CF, Kritsotakis EI, Daniil Z, Tzanakis N, Papaioannou A, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1111-1117 Published Date: 10 October 2014

REVIEW

The causes and consequences of seasonal variation in COPD exacerbations Donaldson GC, Wedzicha JA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1101-1110 Published Date: 6 October 2014

ORIGINAL RESEARCH

The mediating role of cytokine IL-6 on the relationship of FEV1 upon 6-minute walk distance in chronic obstructive pulmonary disease Baldi S, Jose PE, Bruschi C, Pinna GD, Maestri R, Rezzani A, Bellinzona E, Fracchia C, Dacosto E, Crotti P, Montemartini S International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1091-1099 Published Date: 7 October 2014

ORIGINAL RESEARCH

Self-efficacy enhancing intervention increases light physical activity in people with chronic obstructive pulmonary disease Larson JL, Covey MK, Kapella MC, Alex CG, McAuley E International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1081-1090 Published Date: 3 October 2014

REVIEW

The effects of high intensity exercise during pulmonary rehabilitation on ventilatory parameters in people with moderate to severe stable COPD: a systematic review Osterling K, MacFadyen K, Gilbert R, Dechman G International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1069-1079 Published Date: 1 October 2014

ORIGINAL RESEARCH

Reduction of exacerbation frequency in patients with COPD after participation in a comprehensive pulmonary rehabilitation program van Ranst D, Stoop WA, Meijer JW, Otten HJ, van de Port IG International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1059-1067 Published Date: 3 October 2014

ORIGINAL RESEARCH

Impact of COPD in patients with lung cancer and advanced disease treated with chemotherapy and/or tyrosine kinase inhibitors Izquierdo JL, Resano P, El Hachem A, Graziani D, Almonacid C, Sánchez IM International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1053-1058 Published Date: 30 September 2014

ORIGINAL RESEARCH

Relationship between the GOLD combined COPD assessment staging system and bacterial isolation Aydemir Y, Aydemir Ö, Kalem F International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1045-1051 Published Date: 27 September 2014

ORIGINAL RESEARCH

Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states Cunningham TJ, Ford ES, Croft JB, Merrick MT, Rolle IV, Giles WH International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1033-1043 Published Date: 26 September 2014

ORIGINAL RESEARCH

Characteristics of patients with COPD newly prescribed a long-acting bronchodilator: a retrospective cohort study Wurst KE, St Laurent S, Mullerova H, Davis KJ International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1021-1031 Published Date: 25 September 2014

ORIGINAL RESEARCH

A simple semipaced 3-minute chair rise test for routine exercise tolerance testing in COPD Aguilaniu B, Roth H, Gonzalez-Bermejo J, Jondot M, Maitre J, Denis F, Similowski T International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1009-1019 Published Date: 23 September 2014

ORIGINAL RESEARCH

Health status in patients with coexistent COPD and heart failure: a validation and comparison between the Clinical COPD Questionnaire and the Minnesota Living with Heart Failure Questionnaire Berkhof FF, Metzemaekers L, Uil SM, Kerstjens HAM, van den Berg JWK International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:999-1008 Published Date: 22 September 2014

ORIGINAL RESEARCH

Comparison of disease-severity measures within severe and very severe COPD patients: results from a nationally representative chart review and patient survey Solem CT, Sun SX, Liu S, Macahilig C, Katyal M, Gao X, Shorr AF International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:991-998 Published Date: 23 September 2014

ORIGINAL RESEARCH

Volumetric capnography for the evaluation of chronic airways diseases Veronez L, Pereira MC, Doria da Silva SM, Barcaui LA, De Capitani EM, Moreira MM, Paschoal IA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:983-989 Published Date: 23 September 2014

ORIGINAL RESEARCH

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease Barker BL, McKenna S, Mistry V, Pancholi M, Patel H, Haldar K, Barer MR, Pavord ID, Steiner MC, Brightling CE, Bafadhel M International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:975-981 Published Date: 15 September 2014

ORIGINAL RESEARCH

Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation Chuchalin AG, Khaltaev N, Antonov NS, Galkin DV, Manakov LG, Antonini P, Murphy M, Solodovnikov AG, Bousquet J, Pereira MHS, Demko IV International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:963-974 Published Date: 12 September 2014

REVIEW

Distinguishing adult-onset asthma from COPD: a review and a new approach Abramson MJ, Perret JL, Dharmage SC, McDonald VM, McDonald CF International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:945-962 Published Date: 9 September 2014

ORIGINAL RESEARCH

A telehealth program for self-management of COPD exacerbations and promotion of an active lifestyle: a pilot randomized controlled trial Tabak M, Brusse-Keizer M, van der Valk P, Hermens H, Vollenbroek-Hutten M International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:935-944 Published Date: 9 September 2014

ORIGINAL RESEARCH

Central airways remodeling in COPD patients Pini L, Pinelli V, Modina D, Bezzi M, Tiberio L, Tantucci C International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:927-933 Published Date: 1 September 2014

ORIGINAL RESEARCH

Once-daily indacaterol 75 µg in moderate- to-severe COPD: results of a Phase IV study assessing time until patients’ perceived onset of effect Siler TM, LaForce CF, Kianifard F, Williams J, Spangenthal S International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:919-925 Published Date: 1 September 2014

REVIEW

Self-management in patients with COPD: theoretical context, content, outcomes, and integration into clinical care Kaptein AA, Fischer MJ, Scharloo M International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:907-917 Published Date: 1 September 2014

ORIGINAL RESEARCH

Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns Price D, West D, Brusselle G, Gruffydd-Jones K, Jones R, Miravitlles M, Rossi A, Hutton C, Ashton VL, Stewart R, Bichel K International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:889-905 Published Date: 27 August 2014

REVIEW

Epidemiology and clinical impact of major comorbidities in patients with COPD Smith MC, Wrobel JP International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:871-888 Published Date: 27 August 2014

ORIGINAL RESEARCH

Evaluation of ghrelin level and appetite regulation in patients with acute exacerbations of chronic obstructive pulmonary disease Wang Y, Shen Y, Zuo Q, Zhao L, Wan C, Tian P, Chen L, Wen F International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:863-870 Published Date: 14 August 2014

ORIGINAL RESEARCH

Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease Shukla SD, Sohal SS, Mahmood MQ, Reid D, Muller HK, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:853-861 Published Date: 13 August 2014

REVIEW

Noninvasive ventilation in acute respiratory failure Mas A, Masip J International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:837-852 Published Date: 11 August 2014

REVIEW

Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease Tse HN, Tseng CZS International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:825-836 Published Date: 6 August 2014

ORIGINAL RESEARCH

Once-daily long-acting beta-agonists for chronic obstructive pulmonary disease: an indirect comparison of olodaterol and indacaterol Roskell NS, Anzueto A, Hamilton A, Disse B, Becker K International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:813-824 Published Date: 31 July 2014

ORIGINAL RESEARCH

Pulmonary function impairment in patients with combined pulmonary fibrosis and emphysema with and without airflow obstruction Kitaguchi Y, Fujimoto K, Hanaoka M, Honda T, Hotta J, Hirayama J International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:805-811 Published Date: 29 July 2014

ORIGINAL RESEARCH

Characteristics and self-rated health of overlap syndrome Chung JW, Kong KA, Lee JH, Lee SJ, Ryu YJ, Chang JH International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:795-804 Published Date: 21 July 2014

ORIGINAL RESEARCH

Symptoms and impact of symptoms on function and health in patients with chronic obstructive pulmonary disease and chronic heart failure in primary health care Theander K, Hasselgren M, Luhr K, Eckerblad J, Unosson M, Karlsson I International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:785-794 Published Date: 18 July 2014

ORIGINAL RESEARCH

A US database study characterizing patients initiating a budesonide–formoterol combination versus tiotropium bromide as initial maintenance therapy for chronic obstructive pulmonary disease Kern DM, Williams SA, Tunceli O, Wessman C, Zhou S, Pethick N, Elhefni H, Trudo F International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:775-783 Published Date: 18 July 2014

ORIGINAL RESEARCH

Serum cytokine profiling and enrichment analysis reveal the involvement of immunological and inflammatory pathways in stable patients with chronic obstructive pulmonary disease Bade G, Khan MA, Srivastava AK, Khare P, Solaiappan KK, Guleria R, Palaniyar N, Talwar A International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:759-773 Published Date: 5 August 2014

ORIGINAL RESEARCH

Prevalence of chronic obstructive pulmonary disease among adult male cigarettes smokers: a community-based study in Jordan Al Omari M, Khassawneh BY, Khader Y, Dauod AS, Bergus G International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:753-758 Published Date: 17 July 2014

REVIEW

Characterization of airway inflammation in patients with COPD using fractional exhaled nitric oxide levels: a pilot study Donohue JF, Herje N, Crater G, Rickard K International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:745-751 Published Date: 16 July 2014

ORIGINAL RESEARCH

Interleukin-6 and interleukin-8 blood levels’ poor association with the severity and clinical profile of ex-smokers with COPD Moraes MR, da Costa AC, Corrêa KS, Junqueira-Kipnis AP, Rabahi MF International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:735-743 Published Date: 29 July 2014

REVIEW

Influence of diet and obesity on COPD development and outcomes Hanson C, Rutten EP, Wouters EFM, Rennard S International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:723-733 Published Date: 5 August 2014

ORIGINAL RESEARCH

Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:715-721 Published Date: 9 July 2014

ORIGINAL RESEARCH

Lung function efficacy and symptomatic benefit of olodaterol once daily delivered via Respimat® versus placebo and formoterol twice daily in patients with GOLD 2–4 COPD: results from two replicate 48-week studies Koch A, Pizzichini E, Hamilton A, Hart L, Korducki L, De Salvo MC, Paggiaro P International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:697-714 Published Date: 5 July 2014

REVIEW

Differential pharmacology and clinical utility of emerging combination treatments in the management of COPD – role of umeclidinium/vilanterol Malerba M, Morjaria JB, Radaeli A International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:687-695 Published Date: 27 June 2014

CORRIGENDUM

Efficacy of bronchoscopic lung volume reduction: a meta-analysis [Corrigendum] Iftikhar IH, McGuire FR, Musani AI International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:685-686 Published Date: 27 June 2014

ORIGINAL RESEARCH

Extent and prevalence of cognitive dysfunction in chronic obstructive pulmonary disease, chronic non-obstructive bronchitis, and in asymptomatic smokers, compared to normal reference values Dal Negro RW, Bonadiman L, Tognella S, Bricolo FP, Turco P International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:675-683 Published Date: 26 June 2014

ORIGINAL RESEARCH

Roflumilast and dyspnea in patients with moderate to very severe chronic obstructive pulmonary disease: a pooled analysis of four clinical trials Rennard SI, Sun SX, Tourkodimitris S, Rowe P, Goehring UM, Bredenbröker D, Calverley PM International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:657-673 Published Date: 24 June 2014

ORIGINAL RESEARCH

Surveillance of chronic obstructive pulmonary disease in high-risk individuals by using regional lung cancer mass screening Sekine Y, Yanagibori R, Suzuki K, Sugiyama S, Yamaji H, Ishibashi M, Fujisawa T International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:647-656 Published Date: 23 June 2014

ORIGINAL RESEARCH

Efficacy and safety of olodaterol once daily delivered via Respimat® in patients with GOLD 2–4 COPD: results from two replicate 48-week studies Ferguson GT, Feldman GJ, Hofbauer P, Hamilton A, Allen L, Korducki L, Sachs P International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:629-645 Published Date: 16 June 2014

ORIGINAL RESEARCH

Long-term dynamics of death rates of emphysema, asthma, and pneumonia and improving air quality Kravchenko J, Akushevich I, Abernethy AP, Holman S, Ross Jr WG, Lyerly HK International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:613-627 Published Date: 16 June 2014

ORIGINAL RESEARCH

Continuing to Confront COPD International Patient Survey: methods, COPD prevalence, and disease burden in 2012–2013 Landis SH, Muellerova H, Mannino DM, Menezes AM, Han MK, van der Molen T, Ichinose M, Aisanov Z, Oh YM, Davis KJ International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:597-611 Published Date: 6 June 2014

ORIGINAL RESEARCH

Ventilatory requirements of quadriceps resistance training in people with COPD and healthy controls Houchen-Wolloff L, Sandland CJ, Harrison SL, Menon MK, Morgan MD, Steiner MC, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:589-595 Published Date: 5 June 2014

REVIEW

Activity restriction in mild COPD: a challenging clinical problem O'Donnell DE, Gebke KB International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:577-588 Published Date: 4 June 2014

ORIGINAL RESEARCH

Outcomes and costs of treating chronic obstructive pulmonary disease with inhaled fixed combinations: the Italian perspective of the PATHOS study Roggeri A, Micheletto C, Roggeri DP International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:569-576 Published Date: 5 June 2014

ORIGINAL RESEARCH

Prevalence of airflow limitation in outpatients with cardiovascular diseases in Japan Onishi K, Yoshimoto D, Hagan GW, Jones PW International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:563-568 Published Date: 29 May 2014

ORIGINAL RESEARCH

Real-world characterization and differentiation of the Global Initiative for Chronic Obstructive Lung Disease strategy classification Price DB, Baker CL, Zou KH, Higgins VS, Bailey JT, Pike JS International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:551-561 Published Date: 28 May 2014

ORIGINAL RESEARCH

Increased serum levels of lipocalin-1 and -2 in patients with stable chronic obstructive pulmonary disease Wang XR, Li YP, Gao S, Xia W, Gao K, Kong QH, Qi H, Wu L, Zhang J, Qu JM, Bai CX International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:543-549 Published Date: 27 May 2014

ORIGINAL RESEARCH

A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial– mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study Sohal SS, Soltani A, Reid D, Ward C, Wills KE, Muller HK, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:533-542 Published Date: 27 May 2014

ORIGINAL RESEARCH

Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis Primiani A, Dias-Santagata D, Iafrate AJ, Kradin RL International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:525-531 Published Date: 24 May 2014

ORIGINAL RESEARCH

Chronic disease self-management and exercise in COPD as pulmonary rehabilitation: a randomized controlled trial Cameron-Tucker HL, Wood-Baker R, Owen C, Joseph L, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:513-523 Published Date: 19 May 2014

REVIEW

Depression and anxiety predict health-related quality of life in chronic obstructive pulmonary disease: systematic review and meta-analysis Blakemore A, Dickens C, Guthrie E, Bower P, Kontopantelis E, Afzal C, Coventry PA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:501-512 Published Date: 20 May 2014

HYPOTHESIS

Does the duration of smoking cessation have an impact on hospital admission and health-related quality of life amongst COPD patients? Hassan HA, Aziz NA, Hassan Y, Hassan F International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:493-499 Published Date: 14 May 2014

ORIGINAL RESEARCH

Efficacy of bronchoscopic lung volume reduction: a meta-analysis Iftikhar IH, McGuire FR, Musani AI International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:481-491 Published Date: 14 May 2014

REVIEW

Comparative efficacy of inhaled corticosteroid and long-acting beta agonist combinations in preventing COPD exacerbations: a Bayesian network meta-analysis Oba Y, Lone NA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:469-479 Published Date: 12 May 2014

ORIGINAL RESEARCH

Risk of pneumonia with inhaled corticosteroid/long-acting 2 agonist therapy in chronic obstructive pulmonary disease: a cluster analysis DiSantostefano RL, Li H, Hinds D, Galkin DV, Rubin DB International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:457-468 Published Date: 7 May 2014

ORIGINAL RESEARCH

The relationship between early reversibility test and maximal inspiratory pressure in patients with airway obstruction Ozkaya S, Dirican A, Kaya SO, Karanfil RC, Bayrak MG, Bostancı O, Ece F International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:453-456 Published Date: 5 May 2014

ORIGINAL RESEARCH

Living in negotiation: patients’experiences of being in the diagnostic process of COPD Lindgren S, Storli SL, Wiklund-Gustin L International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:441-451 Published Date: 6 May 2014

ORIGINAL RESEARCH

Long-acting bronchodilator use after hospitalization for COPD: an observational study of health insurance claims data Baker CL, Zou KH, Su J International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:431-439 Published Date: 3 May 2014

REVIEW

Corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease Woods JA, Wheeler JS, Finch CK, Pinner NA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:421-430 Published Date: 3 May 2014

CASE SERIES

The successful treatment of hypercapnic respiratory failure with oral modafinil Parnell H, Quirke G, Farmer S, Adeyemo S, Varney V International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:413-419 Published Date: 30 April 2014

REVIEW

Cytokine inhibition in the treatment of COPD Caramori G, Adcock IM, Di Stefano A, Chung KF International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:397-412 Published Date: 28 April 2014

EXPERT OPINION

Expert consensus on acute exacerbation of chronic obstructive pulmonary disease in the People's Republic of China Cai BQ, Cai SX, Chen RC, Cui LY, Feng YL, Gu YT, Huang SG, Liu RY, Liu GN, Shi HZ, Shi Y, Song YL, Sun TY, Wang CZ, Wang JL, Wen FQ, Xiao W, Xu YJ, Yan XX, Yao WZ, Yu Q, Zhang J, Zheng JP, Liu J, Bai CX International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:381-395 Published Date: 25 April 2014

REVIEW

Clinical use of aclidinium in patients with COPD Reid DJ, Carlson AA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:369-379 Published Date: 28 April 2014

ORIGINAL RESEARCH

Assessment of patients' preferences regarding the characteristics associated with the treatment of chronic obstructive pulmonary disease Bulcun E, Ekici M, Ekici A International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:363-368 Published Date: 16 April 2014

REVIEW

Update on obstructive sleep apnea and its relation to COPD Mieczkowski B, Ezzie ME International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:349-362 Published Date: 8 April 2014

ORIGINAL RESEARCH

Explaining the increased health care expenditures associated with gastroesophageal reflux disease among elderly Medicare beneficiaries with chronic obstructive pulmonary disease: a cost-decomposition analysis Ajmera M, Raval AD, Shen C, Sambamoorthi U International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:339-348 Published Date: 8 April 2014

REVIEW

Clinical benefit of fixed-dose dual bronchodilation with glycopyrronium and indacaterol once daily in patients with chronic obstructive pulmonary disease: a systematic review Ulrik CS International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:331-338 Published Date: 1 April 2014

REVIEW

Examining the relationship between anxiety and depression and exacerbations of COPD which result in hospital admission: a systematic review Pooler A, Beech R International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:315-330 Published Date: 29 March 2014

REVIEW

The role of microparticles in chronic obstructive pulmonary disease Takahashi T, Kubo H International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:303-314 Published Date: 27 March 2014

LETTER

Clinical issues of mucus accumulation in COPD Osadnik CR, McDonald CF, Holland AE International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:301-302 Published Date: 25 March 2014

REVIEW

Indirect costs in chronic obstructive pulmonary disease: A review of the economic burden on employers and individuals in the United States Patel JG, Nagar SP, Dalal AA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:289-300 Published Date: 19 March 2014

CORRIGENDUM

Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD [Corrigendum] Buhl R, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:287-288 Published Date: 19 March 2014

REVIEW

New developments in the assessment of COPD: early diagnosis is key Csikesz NG, Gartman EJ International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:277-286 Published Date: 27 February 2014

ORIGINAL RESEARCH

Sleep hypoventilation and daytime hypercapnia in stable chronic obstructive pulmonary disease Holmedahl NH, Øverland B, Fondenes O, Ellingsen I, Hardie JA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:265-275 Published Date: 27 February 2014

ORIGINAL RESEARCH

How do informal self-care strategies evolve among patients with chronic obstructive pulmonary disease managed in primary care? A qualitative study Apps LD, Harrison SL, Williams JE, Hudson N, Steiner M, Morgan MD, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:257-263 Published Date: 26 February 2014

REVIEW

Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD Caramori G, Chung KF, Adcock IM International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:249-256 Published Date: 24 February 2014

CORRIGENDUM

COPD management costs according to the frequency of COPD exacerbations in UK primary care [Corrigendum] Punekar YS, Shukla A, Müllerova H International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:247-248 Published Date: 24 February 2014

REVIEW

A review of halotherapy for chronic obstructive pulmonary disease Rashleigh R, Smith SMS, Roberts NJ International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:239-246 Published Date: 21 February 2014

REVIEW

Bacterial microbiome of lungs in COPD Sze MA, Hogg JC, Sin DD International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:229-238 Published Date: 21 February 2014

ORIGINAL RESEARCH

Efficacy and safety of coadministration of once-daily indacaterol and glycopyrronium versus indacaterol alone in COPD patients: the GLOW6 study Vincken W, Aumann J, Chen H, Henley M, McBryan D, Goyal P International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:215-228 Published Date: 24 February 2014

ORIGINAL RESEARCH

Sex discrepancies in COPD patients and burden of the disease in females: a nationwide study in Greece (Greek Obstructive Lung Disease Epidemiology and health ecoNomics: GOLDEN study) Papaioannou AI, Bania E, Alexopoulos EC, Mitsiki E, Malli F, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:203-213 Published Date: 17 February 2014

REVIEW

Pathogenesis of hyperinflation in chronic obstructive pulmonary disease Gagnon P, Guenette JA, Langer D, Laviolette L, Mainguy V, Maltais F, Ribeiro F, Saey D International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:187-201 Published Date: 15 February 2014

ORIGINAL RESEARCH

Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, doubleblind, placebo-controlled trial Siva R, Bafadhel M, Monteiro W, Brightling CE, Pavord ID International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:179-186 Published Date: 7 February 2014

REVIEW

Biomarkers in chronic obstructive pulmonary disease: confusing or useful? Stockley RA International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:163-177 Published Date: 7 February 2014

ORIGINAL RESEARCH

Changes in plasma levels of B-type natriuretic peptide with acute exacerbations of chronic obstructive pulmonary disease Nishimura K, Nishimura T, Onishi K, Oga T, Hasegawa Y, Jones PW International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:155-162 Published Date: 5 February 2014

LETTER

Anemia and health performance score evaluation as decisive factors for noninvasive mechanical ventilation decisions in AECOPD: are there new key cornerstones? Esquinas AM, Confalonieri M International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:151-154 Published Date: 30 January 2014

REVIEW

Clinical issues of mucus accumulation in COPD Ramos FL, Krahnke JS, Kim V International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:139-150 Published Date: 24 January 2014

REVIEW

Regadenoson use in patients with chronic obstructive pulmonary disease: the state of current knowledge Golzar Y, Doukky R International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:129-137 Published Date: 22 January 2014

ORIGINAL RESEARCH

Barriers to and enablers of physical activity in patients with COPD following a hospital admission: a qualitative study Thorpe O, Kumar S, Johnston K International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:115-128 Published Date: 21 January 2014

ORIGINAL RESEARCH

Efficacy of indacaterol on quality of life and pulmonary function in patients with COPD and inhaler device preferences Ohno T, Wada S, Hanada S, Sawaguchi H, Muraki M, Tohda Y International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:107-114 Published Date: 21 January 2014

ORIGINAL RESEARCH

Factors associated with a prolonged length of stay after acute exacerbation of chronic obstructive pulmonary disease (AECOPD) Wang Y, Stavem K, Dahl FA, Humerfelt S, Haugen T International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:99-105 Published Date: 20 January 2014

ORIGINAL RESEARCH

Time spent by people managing chronic obstructive pulmonary disease indicates biographical disruption Jowsey T, Yen LE, Bagheri N, McRae IS International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:87-97 Published Date: 15 January 2014

CORRIGENDUM

Efficacy and safety of QVA149 compared to the concurrent administration of its monocomponents indacaterol and glycopyrronium: the BEACON study [Corrigendum] Dahl R, Jadayel D, Alagappan VKT, Chen H, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:85-86 Published Date: 16 January 2014

ORIGINAL RESEARCH

The association of chronic obstructive pulmonary disease, disability, engagement in social activities, and mortality among US adults aged 70 years or older, 1994–2006 Liu Y, Croft JB, Anderson LA, Wheaton AG, Presley-Cantrell LR, Ford ES International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:75-83 Published Date: 15 January 2014

ORIGINAL RESEARCH

COPD management costs according to the frequency of COPD exacerbations in UK primary care Punekar YS, Shukla A, Müllerova H International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:65-73 Published Date: 9 January 2014

ORIGINAL RESEARCH

Comparison of clinical features between non-smokers with COPD and smokers with COPD: a retrospective observational study Zhang J, Lin XF, Bai CX International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:57-63 Published Date: 8 January 2014

ORIGINAL RESEARCH

Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease Nath KD, Burel JG, Shankar V, Pritchard AL, Towers M, Looke D, Davies JM, Upham JW International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:51-56 Published Date: 24 December 2013

ORIGINAL RESEARCH

A 1-year follow-up study exploring the associations between perception of illness and healthrelated quality of life in persons with chronic obstructive pulmonary disease Bonsaksen T, Haukeland-Parker S, Lerdal A, Fagermoen MS International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:41-50 Published Date: 19 December 2013

REVIEW

Pulmonary rehabilitation and COPD: providing patients a good environment for optimizing therapy Corhay JL, Nguyen Dang D, Van Cauwenberge H, Louis R International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:27-39 Published Date: 16 December 2013

ORIGINAL RESEARCH

Experience of fatigue, and its relationship to physical capacity and disease severity in men and women with COPD Tödt K, Skargren E, Kentson M, Theander K, Jakobsson P, Unosson M International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:17-25 Published Date: 16 December 2013

ORIGINAL RESEARCH

Effect of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease: a pilot controlled clinical trial Kikuchi H, Shiozawa N, Takata S, Ashida K, Mitsunobu F International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:9-15 Published Date: 12 December 2013

REVIEW

New developments in the management of COPD: clinical utility of indacaterol 75 µg Steiropoulos P, Archontogeorgis K, Nena E, Bouros D International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:1-7 Published Date: 6 December 2013

ORIGINAL RESEARCH

Exacerbation-related impairment of quality of life and work productivity in severe and very severe chronic obstructive pulmonary disease Solem CT, Sun SX, Sudharshan L, Macahilig C, Katyal M, Gao X International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:641-652 Published Date: 10 December 2013

ORIGINAL RESEARCH

Hospital readmissions following initiation of nebulized arformoterol tartrate or nebulized shortacting beta-agonists among inpatients treated for COPD Bollu V, Ernst FR, Karafilidis J, Rajagopalan K, Robinson SB, Braman SS International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:631-639 Published Date: 6 December 2013

ORIGINAL RESEARCH

Standardized evaluation of lung congestion during COPD exacerbation better identifies patients at risk of dying Høiseth AD, Omland T, Karlsson BD, Brekke PH, Søyseth V International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:621-629 Published Date: 6 December 2013

ORIGINAL RESEARCH

Indacaterol therapy in moderate-to-severe chronic obstructive pulmonary disease: findings from a single-center primary care cohort Singh MP International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:613-619 Published Date: 9 December 2013

ORIGINAL RESEARCH

Use of a care bundle in the emergency department for acute exacerbations of chronic obstructive pulmonary disease: a feasibility study McCarthy C, Brennan JR, Brown L, Donaghy D, Jones P, Whelan R, McCormack N, Callanan I, Ryan J, McDonnell TJ International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:605-611 Published Date: 28 November 2013

ORIGINAL RESEARCH

Impact of night-time symptoms in COPD: a real-world study in five European countries Price D, Small M, Milligan G, Higgins V, Garcia Gil E, Estruch J International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:595-603 Published Date: 27 November 2013

ORIGINAL RESEARCH

Diagnostic electrocardiographic dyad criteria of emphysema in left ventricular hypertrophy Lanjewar SS, Chhabra L, Chaubey VK, Joshi S, Kulkarni G, Kothagundla C, Kaul S, Spodick DH International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:591-594 Published Date: 22 November 2013

ORIGINAL RESEARCH

Noninvasive positive pressure ventilation in subjects with stable COPD: a randomized trial Bhatt SP, Peterson MW, Wilson JS, Durairaj L International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:581-589 Published Date: 22 November 2013

ORIGINAL RESEARCH

Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients De Backer J, Vos W, Van Holsbeke C, Vinchurkar S, Claes R, Parizel PM, De Backer W International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:569-579 Published Date: 22 November 2013

ORIGINAL RESEARCH

The health care burden of high grade chronic obstructive pulmonary disease in Korea: analysis of the Korean Health Insurance Review and Assessment Service data Kim JH, Rhee CK, Yoo KH, Kim YS, Lee SW, Park YB, Lee JH, Oh YM, Lee SD, Kim Y, Kim KJ, Yoon HK International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:561-568 Published Date: 19 November 2013

ORIGINAL RESEARCH

Risk assessment of readmissions following an initial COPD-related hospitalization Baker CL, Zou KH, Su J International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:551-559 Published Date: 12 November 2013

SHORT REPORT

Over diagnosis of chronic obstructive pulmonary disease in an underserved patient population Ghattas C, Dai A, Gemmel DJ, Awad MH International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:545-549 Published Date: 12 November 2013

ORIGINAL RESEARCH

Home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized clinical trial Dias FD, Sampaio LMM, da Silva GA, Dantas Gomes ELF, Nascimento ESP, Santos Alves VL, Stirbulov R, Costa D International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:537-544 Published Date: 5 November 2013

LETTER

Chronic obstructive pulmonary disease exacerbation frequency and severity Stafyla E, Kerenidi T, Gourgoulianis KI International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:533-535 Published Date: 6 November 2013

ORIGINAL RESEARCH

Changes in the airway lumen and surrounding parenchyma in chronic obstructive pulmonary disease Kurashima K, Hoshi T, Takaku Y, Kanauchi T, Nakamoto K, Ueda M, Takayanagi N, Colby TV, Sugita Y, Kawabata Y International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:523-532 Published Date: 30 October 2013

REVIEW

Pathophysiology and clinical implications of pulmonary arterial enlargement in COPD Wells JM, Dransfield MT International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:509-521 Published Date: 29 October 2013

ORIGINAL RESEARCH

Efficacy and safety of QVA149 compared to the concurrent administration of its monocomponents indacaterol and glycopyrronium: the BEACON study Dahl R, Jadayel D, Alagappan VKT, Chen H, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:501-508 Published Date: 17 October 2013

ORIGINAL RESEARCH

Development and validation of a model to predict the risk of exacerbations in chronic obstructive pulmonary disease Bertens LCM, Reitsma JB, Moons KGM, van Mourik Y, Lammers JWJ, Broekhuizen BDL, Hoes AW, Rutten FH International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:493-499 Published Date: 10 October 2013

ORIGINAL RESEARCH

SOSPES: SPIRIVA® observational study measuring SGRQ score in routine medical practice in Central and Eastern Europe Fležar M, Jahnz-Różyk K, Enache G, Martynenko T, Kristufek P, Škrinjarić-Cincar S, Kadlecová P, Martinovic G, International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:483-492 Published Date: 9 October 2013

ORIGINAL RESEARCH

Impact of active and passive smoking as risk factors for asthma and COPD in women presenting to primary care in Syria: first report by the WHO-GARD survey group Mohammad Y, Shaaban R, Abou Al-Zahab B, Khaltaev N, Bousquet J, Dubaybo B International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:473-482 Published Date: 2 October 2013

REVIEW

COPD management: role of symptom assessment in routine clinical practice van der Molen T, Miravitlles M, Kocks JWH International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:461-471 Published Date: 14 October 2013

ORIGINAL RESEARCH

A study to assess COPD Symptom-based Management and to Optimise treatment Strategy in Japan (COSMOS-J) based on GOLD 2011 Betsuyaku T, Kato M, Fujimoto K, Hagan G, Kobayashi A, Hitosugi H, James M, Jones PW International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:453-459 Published Date: 3 October 2013

REVIEW

Evidence for cognitive–behavioral strategies improving dyspnea and related distress in COPD Norweg A, Collins EG International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:439-451 Published Date: 25 September 2013

ORIGINAL RESEARCH

MIOTIC study: a prospective, multicenter, randomized study to evaluate the long-term efficacy of mobile phone-based Internet of Things in the management of patients with stable COPD Zhang J, Song YL, Bai CX International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:433-438 Published Date: 19 September 2013

REVIEW

Role of indacaterol and the newer very long-acting 2-agonists in patients with stable COPD: a review Ridolo E, Montagni M, Olivieri E, Riario-Sforza GG, Incorvaia C International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:425-432 Published Date: 18 September 2013

ORIGINAL RESEARCH

Comparative efficacy of aclidinium versus glycopyrronium and tiotropium, as maintenance treatment of moderate to severe COPD patients: a systematic review and network meta-analysis Karabis A, Lindner L, Mocarski M, Huisman E, Greening A International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:405-423 Published Date: 9 September 2013

ORIGINAL RESEARCH

Quantitative assessment of walking time and postural change in patients with COPD using a new triaxial accelerometer system Kawagoshi A, Kiyokawa N, Sugawara K, Takahashi H, Sakata S, Miura S, Sawamura S, Satake M, Shioya T International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:397-404 Published Date: 2 September 2013

ORIGINAL RESEARCH

Spirometry is underused in the diagnosis and monitoring of patients with chronic obstructive pulmonary disease (COPD) Yu WC, Fu SN, Tai EL, Yeung YC, Kwong KC, Chang Y, Tam CM, Yiu YK International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:389-395 Published Date: 26 August 2013

ORIGINAL RESEARCH

Drugs potentially affecting the extent of airways reversibility on pulmonary function testing are frequently consumed despite guidelines Jones TE, Southcott A, Homan S International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:383-388 Published Date: 9 August 2013

LETTER

Predicting survival after acute exacerbation chronic obstructive pulmonary disease (ACOPD): is long-term application of noninvasive ventilation the last life guard? Esquinas AM, Matsuoka Y, Stieglitz S International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:379-381 Published Date: 7 August 2013

ORIGINAL RESEARCH

Should chest examination be reinstated in the early diagnosis of chronic obstructive pulmonary disease? Oshaug K, Halvorsen PA, Melbye H International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:369-377 Published Date: 31 July 2013

LETTER

COPD exacerbations admitted to intensive care unit. Organization, mortality, and noninvasive or invasive mechanical ventilation strategies: are they sufficiently well known? Esquinas AM International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:365-367 Published Date: 29 July 2013

REVIEW

Indacaterol: a comprehensive review Rossi A, Polese G International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:353-363 Published Date: 25 July 2013

ORIGINAL RESEARCH

The 6-minute pegboard and ring test is correlated with upper extremity activity of daily living in chronic obstructive pulmonary disease Takeda K, Kawasaki Y, Yoshida K, Nishida Y, Harada T, Yamaguchi K, Ito S, Hashimoto K, Matsumoto S, Yamasaki A, Igishi T, Shimizu E International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:347-351 Published Date: 23 July 2013

REVIEW

Helping COPD patients change health behavior in order to improve their quality of life Almagro P, Castro A International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:335-345 Published Date: 24 July 2013

ORIGINAL RESEARCH

Efficacy of levofloxacin versus cefuroxime in treating acute exacerbations of chronic obstructive pulmonary disease Yoon HI, Lee CH, Kim DK, Park GM, Lee SM, Yim JJ, Kim JY, Lee JH, Lee CT, Chung HS, Kim YW, Han SK, Yoo CG International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:329-334 Published Date: 10 July 2013

ORIGINAL RESEARCH

The development and pilot testing of the Self-management Programme of Activity, Coping and Education for Chronic Obstructive Pulmonary Disease (SPACE for COPD) Apps LD, Mitchell KE, Harrison SL, Sewell L, Williams JE, Young HML, Steiner M, Morgan M, Singh SJ International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:317-327 Published Date: 9 July 2013

LETTER

Shrinking the room for invasive mechanical ventilation in acute chronic hypercapnic respiratory failure: yes, but must be sure to have opened windows for noninvasive ventilation Rodriguez AME, Scala R, Ambrosino N International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:313-315 Published Date: 9 July 2013

REVIEW

The association between COPD and heart failure risk: a review de Miguel Díez J, Chancafe Morgan J, Jiménez García R International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:305-312 Published Date: 28 June 2013

ORIGINAL RESEARCH

Inhaled corticosteroid use in patients with chronic obstructive pulmonary disease and the risk of pneumonia: a retrospective claims data analysis Yawn BP, Li YF, Tian HJ, Zhang J, Arcona S, Kahler KH International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:295-304 Published Date: 27 June 2013

ORIGINAL RESEARCH

Inhaled anticholinergic use and all-cause mortality among elderly Medicare beneficiaries with chronic obstructive pulmonary disease Ajmera M, Shen C, Pan X, Findley PA, Rust G, Sambamoorthi U International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:287-294 Published Date: 10 June 2013

ORIGINAL RESEARCH

Day-to-day measurement of patient-reported outcomes in exacerbations of chronic obstructive pulmonary disease Kocks JWH, van den Berg JWK, Kerstjens HAM, Uil SM, Vonk JM, de Jong YP, Tsiligianni IG, van der Molen T International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:273-286 Published Date: 6 June 2013

ORIGINAL RESEARCH

A comparison of three multidimensional indices of COPD severity as predictors of future exacerbations Motegi T, Jones RC, Ishii T, Hattori K, Kusunoki Y, Furutate R, Yamada K, Gemma A, Kida K International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:259-271 Published Date: 31 May 2013

LETTER

Noninvasive mechanical ventilation with high pressure strategy remains a “double edged sword”? Esquinas AM, Siscaro G, Clini EM International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:255-258 Published Date: 27 May 2013

LETTER

The dangers of incense burning: COPD in Saudi Arabia Al-Kassimi FA International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:251-253 Published Date: 21 May 2013

ORIGINAL RESEARCH

P-wave indices in patients with pulmonary emphysema: do P-terminal force and interatrial block have confounding effects? Chhabra L, Chaubey VK, Kothagundla C, Bajaj R, Kaul S, Spodick DH International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:245-250 Published Date: 14 May 2013

ORIGINAL RESEARCH

Effect of a network system for providing proper inhalation technique by community pharmacists on clinical outcomes in COPD patients Takemura M, Mitsui K, Ido M, Matsumoto M, Koyama M, Inoue D, Takamatsu K, Itotani R, Ishitoko M, Suzuki S, Aihara K, Sakuramoto M, Kagioka H, Fukui M International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:239-244 Published Date: 9 May 2013

REVIEW

Symptom variability in COPD: a narrative review Lopez-Campos JL, Calero C, Quintana-Gallego E International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:231-238 Published Date: 7 May 2013

REVIEW

Efficacy and safety of eco-friendly inhalers: focus on combination ipratropium bromide and albuterol in chronic obstructive pulmonary disease Panos RJ International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:221-230 Published Date: 30 April 2013

ORIGINAL RESEARCH

Long-term survival for COPD patients receiving noninvasive ventilation for acute respiratory failure Titlestad IL, Lassen AT, Vestbo J International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:215-219 Published Date: 26 April 2013

ORIGINAL RESEARCH

The relationship between self-management abilities, quality of chronic care delivery, and wellbeing among patients with chronic obstructive pulmonary disease in The Netherlands Cramm JM, Nieboer AP International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:209-214 Published Date: 26 April 2013

ORIGINAL RESEARCH

Diagnosis of COPD and clinical course in patients with unrecognized airflow limitation Murphy DE, Panos RJ International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:199-208 Published Date: 18 April 2013

ORIGINAL RESEARCH

Sweeper’s lung disease: a cross-sectional study of an overlooked illness among sweepers of Pakistan Anwar SK, Mehmood N, Nasim N, Khurshid M, Khurshid B International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:193-197 Published Date: 17 April 2013

ORIGINAL RESEARCH

Evaluation of effects of shoulder girdle training on strength and performance of activities of daily living in patients with chronic obstructive pulmonary disease Velloso M, do Nascimento NH, Gazzotti MR, Jardim JR International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:187-192 Published Date: 9 April 2013

ORIGINAL RESEARCH

Exacerbations among chronic bronchitis patients treated with maintenance medications from a US managed care population: an administrative claims data analysis AbuDagga A, Sun SX, Tan H, Solem CT International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:175-185 Published Date: 9 April 2013

ORIGINAL RESEARCH

Inspiratory drive is related to dynamic pulmonary hyperinflation in COPD patients Gatta D, Fredi M, Aliprandi G, Pini L, Tantucci C International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:169-173 Published Date: 28 March 2013

ORIGINAL RESEARCH

Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study Mehta R, Kelleher D, Preece A, Hughes S, Crater G International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:159-167 Published Date: 27 March 2013

ORIGINAL RESEARCH

Anemia and performance status as prognostic markers in acute hypercapnic respiratory failure due to chronic obstructive pulmonary disease Haja Mydin H, Murphy S, Clague H, Sridharan K, Taylor IK International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:151-157 Published Date: 24 March 2013

ORIGINAL RESEARCH

COPD patient satisfaction with ipratropium bromide/albuterol delivered via Respimat: a randomized, controlled study Ferguson GT, Ghafouri M, Dai L, Dunn LJ International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:139-150 Published Date: 19 March 2013

RAPID COMMUNICATION

Shrinking the room for invasive ventilation in hypercapnic respiratory failure Scarpazza P, Incorvaia C, Melacini C, Cattaneo R, Bonacina C, Riario-Sforza GG, Casali W International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:135-137 Published Date: 15 March 2013

ORIGINAL RESEARCH

Prevalence of renal and hepatobiliary disease, laboratory abnormalities, and potentially toxic medication exposures among persons with COPD Mapel DW, Marton JP International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:127-134 Published Date: 15 March 2013

REVIEW

Ten years of tiotropium: clinical impact and patient perspectives Yohannes AM, Connolly MJ, Hanania NA International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:117-125 Published Date: 15 March 2013

ORIGINAL RESEARCH

Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease Kosoglou T, Hubbell J, Xuan F, Cutler DL, Meehan AG, Kantesaria B, Wittmer BA International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:107-116 Published Date: 4 March 2013

LETTER

Chronic obstructive pulmonary disease as a cardiovascular risk factor: results of a case-control study (CONSISTE study) Falola M International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:105-106 Published Date: 21 February 2013

ORIGINAL RESEARCH

Supplemental vitamin D and physical performance in COPD: a pilot randomized trial Bjerk SM, Edgington BD, Rector TS, Kunisaki KM International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:97-104 Published Date: 15 February 2013

REVIEW

Improving the quality of life in patients with chronic obstructive pulmonary disease: focus on indacaterol Feldman GJ International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:89-96 Published Date: 14 February 2013

ORIGINAL RESEARCH

Cost-effectiveness of roflumilast in combination with bronchodilator therapies in patients with severe and very severe COPD in Switzerland Samyshkin Y, Schlunegger M, Haefliger S, Ledderhose S, Radford M International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:79-87 Published Date: 30 January 2013

ORIGINAL RESEARCH

The search for common pathways underlying asthma and COPD Kaneko Y, Yatagai Y, Yamada H, Iijima H, Masuko H, Sakamoto T, Hizawa N International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:65-78 Published Date: 25 January 2013

REVIEW

The safety of long-acting ß2-agonists in the treatment of stable chronic obstructive pulmonary disease Decramer ML, Hanania NA, Lötvall JO, Yawn BP International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:53-64 Published Date: 25 January 2013

ORIGINAL RESEARCH

Deficiency of -1-antitrypsin influences systemic iron homeostasis Ghio AJ, Soukup JM, Richards JH, Fischer BM, Voynow JA, Schmechel DE International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:45-51 Published Date: 22 January 2013

ORIGINAL RESEARCH

Optimal electrocardiographic limb lead set for rapid emphysema screening Bajaj R, Chhabra L, Basheer Z, Spodick DH International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:41-44 Published Date: 19 January 2013

ORIGINAL RESEARCH

Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities Oh YM, Bhome AB, Boonsawat W, Gunasekera KD, Madegedara D, Idolor L, Roa C, Kim WJ, Kuo HP, Wang CH, Lan LT, Loh LC, Ong CK, Ng A, Nishimura M, Makita H, Silverman EK, Lee JS, Yang T, Lin Y, Wang C, Lee SD International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:31-39 Published Date: 14 January 2013

REVIEW

A challenge to the seven widely believed concepts of COPD Al-Kassmimi FA, Alhamad EH International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:21-30 Published Date: 14 January 2013

ORIGINAL RESEARCH

Managing mood disorders in patients attending pulmonary rehabilitation clinics Doyle C, Dunt D, Ames D, Selvarajah S International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:15-20 Published Date: 4 January 2013

REVIEW

Dysfunctional lung anatomy and small airways degeneration in COPD Martin C, Frija J, Burgel PR International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:7-13 Published Date: 4 January 2013

ORIGINAL RESEARCH

Indacaterol improves daily physical activity in patients with chronic obstructive pulmonary disease Hataji O, Naito M, Ito K, Watanabe F, Gabazza EC, Taguchi O International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:1-5 Published Date: 28 December 2012

ORIGINAL RESEARCH

Clinical COPD Questionnaire score (CCQ) and mortality Sundh J, Janson C, Lisspers K, Montgomery S, Ställberg B International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:833-842 Published Date: 20 December 2012

ORIGINAL RESEARCH

Vulnerability of patients with chronic obstructive pulmonary disease according to gender in China Lou P, Zhu Y, Chen P, Zhang P, Yu J, Zhang N, Zhang L, Wu H, Zhao J, Chen N International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:825-832 Published Date: 20 December 2012

ORIGINAL RESEARCH

Chronic obstructive pulmonary disease: hospital and intensive care unit outcomes in the Kingdom of Saudi Arabia Alaithan AM, Memon JI, Rehmani RS, Qureshi AA, Salam A International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:819-823 Published Date: 18 December 2012

ORIGINAL RESEARCH

High pressure versus high intensity noninvasive ventilation in stable hypercapnic chronic obstructive pulmonary disease: a randomized crossover trial Murphy PB, Brignall K, Moxham J, Polkey MI, Davidson AC, Hart N International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:811-818 Published Date: 11 December 2012

LETTER

Noninvasive mechanical ventilation with BiPAP therapy for comatose exacerbation of chronic obstructive pulmonary disease through an endotracheal tube: is it justified? Esquinas A, Agarwal R International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:807-809 Published Date: 3 December 2012

ORIGINAL RESEARCH

Effects of inspiratory muscle training on dynamic hyperinflation in patients with COPD Petrovic M, Reiter M, Zipko H, Pohl W, Wanke T International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:797-805 Published Date: 30 November 2012

ORIGINAL RESEARCH

Relationship between frequency, length, and treatment outcome of exacerbations to baseline lung function and lung density in alpha-1 antitrypsin-deficient COPD Vijayasaratha K, Stockley RA International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:789-796 Published Date: 27 November 2012

ORIGINAL RESEARCH

Patient characteristics, treatment patterns, and health outcomes among COPD phenotypes Allen-Ramey FC, Gupta S, DiBonaventura MD International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:779-787 Published Date: 22 November 2012

ORIGINAL RESEARCH

Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease Albert RK, Connett J, Curtis JL, Martinez FJ, Han MK, Lazarus SC, Woodruff PG International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:767-777 Published Date: 23 November 2012

CORRIGENDUM

Corrigendum Tashkin DP, Doherty DE, Kerwin E, Matiz-Bueno CE, Knorr B, Shekar T, Banerjee S, Staudinger H International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:765-766 Published Date: 16 November 2012

ORIGINAL RESEARCH

Impact of exacerbations on health care cost and resource utilization in chronic obstructive pulmonary disease patients with chronic bronchitis from a predominantly Medicare population Pasquale MK, Sun SX, Song F, Hartnett HJ, Stemkowski SA International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:757-764 Published Date: 1 November 2012

ORIGINAL RESEARCH

Physical inactivity in COPD and increased patient perception of dyspnea Katajisto M, Kupiainen H, Rantanen P, Lindqvist A, Kilpeläinen M, Tikkanen H, Laitinen T International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:743-755 Published Date: 29 October 2012

REVIEW

Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD Buhl R, Banerji D International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:729-741 Published Date: 26 October 2012

ORIGINAL RESEARCH

Randomized trial of pragmatic education for low-risk COPD patients: impact on hospitalizations and emergency department visits Siddique HH, Olson RH, Parenti CM, Rector TS, Caldwell M, Dewan NA, Rice KL International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:719-728 Published Date: 25 October 2012

ORIGINAL RESEARCH

Relationship between oxygen consumption kinetics and BODE Index in COPD patients Borghi-Silva A, Beltrame T, Reis MS, Sampaio LM, Catai AM, Arena R, Costa D International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:711-718 Published Date: 17 October 2012

REVIEW

Beyond FEV1 in COPD: a review of patient-reported outcomes and their measurement Jones P, Miravitlles M, van der Molen T, Kulich K International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:697-709 Published Date: 16 October 2012

ORIGINAL RESEARCH

The effects of weekly augmentation therapy in patients with PiZZ 1-antitrypsin deficiency Schmid ST, Koepke J, Dresel M, Hattesohl A, Frenzel E, Perez J, Lomas DA, Miranda E, Greulich T, Noeske S, Wencker M, Teschler H, Vogelmeier C, Janciauskiene S, Koczulla AR International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:687-696 Published Date: 28 September 2012

ORIGINAL RESEARCH

Chronic obstructive pulmonary disease as a cardiovascular risk factor. Results of a case–control study (CONSISTE study) de Lucas-Ramos P, Izquierdo-Alonso JL, Rodriguez Gonzalez-Moro JM, Fernandez Frances J, Vaquero Lozano P, Bellón-Cano JM International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:679-686 Published Date: 1 October 2012

REVIEW

Once-daily glycopyrronium bromide, a long-acting muscarinic antagonist, for chronic obstructive pulmonary disease: a systematic review of clinical benefit Ulrik CS International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:673-678 Published Date: 26 September 2012

ORIGINAL RESEARCH

Acute effects of intrapulmonary percussive ventilation in COPD patients assessed by using conventional outcome parameters and a novel computational fluid dynamics technique Ides K, Vos W, De Backer L, Vissers D, Claes R, Leemans G, Ongena K, Peters O, De Backer W International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:667-671 Published Date: 25 September 2012

LETTER

GOLD and the fixed ratio Vestbo J International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:663-665 Published Date: 25 September 2012

ORIGINAL RESEARCH

Exacerbation frequency and course of COPD Halpin DMG, Decramer M, Celli B, Kesten S, Liu D, Tashkin DP International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:653-661 Published Date: 21 September 2012

REVIEW

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease Ito K, Colley T, Mercado N International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:641-652 Published Date: 21 September 2012

ORIGINAL RESEARCH

The role of small heat-shock protein B-crystalline (HspB5) in COPD pathogenesis Cherneva RV, Georgiev OB, Petrova DS, Trifonova NL, Stamenova M, Ivanova V, Vlasov VI International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:633-640 Published Date: 4 October 2012

REVIEW

Updates on the COPD gene list Bossé Y International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:607-631 Published Date: 18 September 2012

REVIEW

Challenge models to assess new therapies in chronic obstructive pulmonary disease van der Merwe R, Molfino NA International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:597-605 Published Date: 13 September 2012

REVIEW

Effects of inhaled corticosteroids on airway inflammation in chronic obstructive pulmonary disease: a systematic review and meta-analysis Jen R, Rennard SI, Sin DD International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:587-595 Published Date: 19 September 2012

ORIGINAL RESEARCH

Correlates of COPD and chronic bronchitis in nonsmokers: data from a cross-sectional study Waked M, Salame J, Khayat G, Salameh P International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:577-585 Published Date: 7 September 2012

ORIGINAL RESEARCH

Long-term survival in patients hospitalized for chronic obstructive pulmonary disease: a prospective observational study in the Nordic countries Gudmundsson G, Ulrik CS, Gislason T, Lindberg E, Brøndum E, Bakke P, Janson C International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:571-576 Published Date: 14 September 2012

REVIEW

Lung microbiology and exacerbations in COPD Beasley V, Joshi PV, Singanayagam A, Molyneaux PL, Johnston SL, Mallia P International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:555-569 Published Date: 31 August 2012

ORIGINAL RESEARCH

Assessing patient report of function: content validity of the Functional Performance InventoryShort Form (FPI-SF) in patients with chronic obstructive pulmonary disease (COPD) Leidy NK, Hamilton A, Becker K International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:543-554 Published Date: 30 August 2012

ORIGINAL RESEARCH

Associations between isokinetic muscle strength, high-level functional performance, and physiological parameters in patients with chronic obstructive pulmonary disease Butcher SJ, Pikaluk BJ, Chura RL, Walkner MJ, Farthing JP, Marciniuk DD International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:537-542 Published Date: 22 August 2012

REVIEW

Muscle function in COPD: a complex interplay Donaldson AV, Maddocks M, Martolini D, Polkey MI, Man WD-C International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:523-535 Published Date: 17 August 2012

ORIGINAL RESEARCH

Association of plasma adiponectin levels with cellular hydration state measured using bioelectrical impedance analysis in patients with COPD Yoshikawa T, Kanazawa H International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:515-521 Published Date: 10 August 2012

ORIGINAL RESEARCH

Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial Beeh KM, Singh D, Di Scala L, Drollmann A International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:503-513 Published Date: 31 July 2012

REVIEW

Practical aspects of inhaler use in the management of chronic obstructive pulmonary disease in the primary care setting Yawn BP, Colice GL, Hodder R International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:495-502 Published Date: 25 July 2012

REVIEW

Epidemiology of chronic obstructive pulmonary disease: a literature review Rycroft CE, Heyes A, Lanza L, Becker K International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:457-494 Published Date: 20 July 2012

ORIGINAL RESEARCH

Assessment of COPD wellness tools for use in primary care: an IPCRG initiative Cave AJ, Atkinson L, Tsiligianni IG, Kaplan AG International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:447-456 Published Date: 17 July 2012

METHODOLOGY

Design, rationale, and baseline demographics of SEARCH I: a prospective cluster-randomized study Albers F, Shaikh A, Iqbal A International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:437-445 Published Date: 11 July 2012

ORIGINAL RESEARCH

Clinical diaries in COPD: compliance and utility in predicting acute exacerbations Walters EH, Walters J, Wills KE, Robinson A, Wood-Baker R International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:427-435 Published Date: 10 July 2012

ORIGINAL RESEARCH

The importance of knowing the home conditions of patients receiving long-term oxygen therapy Godoy I, Tanni SE, Hernández C, Godoy I International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:421-425 Published Date: 5 July 2012

SHORT REPORT

Efficacy of indacaterol 75 µg versus fixed-dose combinations of formoterol-budesonide or salmeterol-fluticasone for COPD: a network meta-analysis Cope S, Kraemer M, Zhang J, Capkun-Niggli G, Jansen JP International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:415-420 Published Date: 5 July 2012

ORIGINAL RESEARCH

Clinical trial of community nurse mentoring to improve self-management in patients with chronic obstructive pulmonary disease Wood-Baker R, Reid D, Robinson A, Walters EH International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:407-413 Published Date: 4 July 2012

ORIGINAL RESEARCH

Characterization of outcomes 1 year after endoscopic thermal vapor ablation for patients with heterogeneous emphysema Herth FJ, Ernst A, Baker KM, Egan JJ, Gotfried MH, Hopkins P, Stanzel F, Valipour A, Wagner M, Witt C, Kesten S, Snell G International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:397-405 Published Date: 18 July 2012

ORIGINAL RESEARCH

Diagnosis of airway obstruction in the elderly: contribution of the SARA study Sorino C, Battaglia S, Scichilone N, Pedone C, Antonelli-Incalzi R, Sherrill D, Bellia V International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:389-395 Published Date: 27 June 2012

CASE REPORT

Genetic, host, and environmental interactions in a 19 year old with severe chronic obstructive lung disease; observations regarding the pathophysiology of airflow obstruction Grosu HB, Killam J, Khusainova E, Lozada J,Needelman A, Eden E International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:383-388 Published Date: 22 June 2012

ORIGINAL RESEARCH

Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? the REACT study protocol Calverley PM, Martinez FJ, Fabbri LM, Goehring UM, Rabe KF International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:375-382 Published Date: 20 June 2012

ORIGINAL RESEARCH

Bronchial hyperresponsiveness in women with chronic obstructive pulmonary disease related to wood smoke González-García M, Torres-Duque CA, Bustos A, Jaramillo C, Maldonado D International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:367-373 Published Date: 15 June 2012

ORIGINAL RESEARCH

Signs of progress in the Australian post-2000 COPD experience, but some old problems remain Dunt D, Doyle C International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:357-366 Published Date: 7 June 2012

ORIGINAL RESEARCH

Proposing a standardized method for evaluating patient report of the intensity of dyspnea during exercise testing in COPD Hareendran A, Leidy NK, Monz BU, Winnette R, Becker K, Mahler DA International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:345-355 Published Date: 28 May 2012

ORIGINAL RESEARCH

Excellent adherence and no contamination by physiotherapists involved in a randomized controlled trial on reactivation of COPD patients: a qualitative process evaluation study Effing TW, Krabbenbos M, Pieterse ME, van der Valk PDLPM, Zielhuis GA, Kerstjens HAM, van der Palen J International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:337-344 Published Date: 25 May 2012

ORIGINAL RESEARCH

Microbiological study of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the usefulness of analytical and clinical parameters in its identification (VIRAE study) Boixeda R, Rabella N, Sauca G, Delgado M, Martínez-Costa X, Mauri M, Vicente V, Palomera E, Serra-Prat M, Capdevila JA International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:327-335 Published Date: 25 May 2012

ORIGINAL RESEARCH

Role of BiPAP applied through endotracheal tube in unconscious patients suffering from acute exacerbation of COPD: a pilot study Rawat J, Sindhwani G, Biswas D, Dua R International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:321-325 Published Date: 11 May 2012

REVIEW

Exercise prescription for hospitalized people with chronic obstructive pulmonary disease and comorbidities: a synthesis of systematic reviews Reid WD, Yamabayashi C, Goodridge D, Chung F, Hunt MA, Marciniuk DD, Brooks D, Chen YW, Hoens AM, Camp PG International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:297-320 Published Date: 14 May 2012

ORIGINAL RESEARCH

Correlation of health-related quality of life with other disease severity indices in Indian chronic obstructive pulmonary disease patients Shavro SA, Ezhilarasu P, Augustine J, Bechtel JJ, Christopher DJ International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:291-296 Published Date: 1 May 2012

ORIGINAL RESEARCH

Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma Kitaguchi Y, Komatsu Y, Fujimoto K, Hanaoka M, Kubo K International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:283-289 Published Date: 12 April 2012

ORIGINAL RESEARCH

Primary care physician perceptions on the diagnosis and management of chronic obstructive pulmonary disease in diverse regions of the world Aisanov Z, Bai CX, Bauerle O, Colodenco FD, Feldman C, Hashimoto S, Jardim J, Lai CKW, Laniado-Laborin R, Nadeau G, Sayiner A, Shim JJ, Tsai YH, Walters RD, Waterer G International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:271-282 Published Date: 5 April 2012

ORIGINAL RESEARCH

Dynamic change in respiratory resistance during inspiratory and expiratory phases of tidal breathing in patients with chronic obstructive pulmonary disease Yamauchi Y, Kohyama T, Jo T, Nagase T International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:259-269 Published Date: 11 April 2012

ORIGINAL RESEARCH

Epidemiology of chronic obstructive pulmonary disease: a descriptive study in the mid-western region of Nepal Bhandari R, Sharma R International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:253-257 Published Date: 4 April 2012

ORIGINAL RESEARCH

Effect of theophylline on exercise capacity in COPD patients treated with combination longacting bronchodilator therapy: a pilot study Voduc N, Alvarez GG, Amjadi K, Tessier C, Sabri E, Aaron SD International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:245-252 Published Date: 29 March 2012

ORIGINAL RESEARCH

Alveolar fractal box dimension inversely correlates with mean linear intercept in mice with elastase-induced emphysema Andersen MP, Parham AR, Waldrep JC, McKenzie WN, Dhand R International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:235-243 Published Date: 27 March 2012

METHODOLOGY

Clinical and economic outcomes in an observational study of COPD maintenance therapies: multivariable regression versus propensity score matching Roberts MH, Dalal AA International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:221-233 Published Date: 22 March 2012

ORIGINAL RESEARCH

The burden of chronic obstructive pulmonary disease among employed adults DiBonaventura MD, Paulose-Ram R, Su J, McDonald M, Zou KH, Wagner JS, Shah H International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:211-219 Published Date: 19 March 2012

ORIGINAL RESEARCH

Adherence to current guidelines for chronic obstructive pulmonary disease (COPD) among patients treated with combination of long-acting bronchodilators or inhaled corticosteroids Asche CV, Leader S, Plauschinat C, Raparla S, Yan M, Ye X, Young D International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:201-209 Published Date: 15 March 2012

ORIGINAL RESEARCH

Cost-effectiveness of available treatment options for patients suffering from severe COPD in the UK: a fully incremental analysis Hertel N, Kotchie RW, Samyshkin Y, Radford M, Humphreys S, Jameson K International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:183-199 Published Date: 19 March 2012

ORIGINAL RESEARCH

Fibrinogen, chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts Valvi D, Mannino DM, Müellerova H, Tal-Singer R International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:173-182 Published Date: 7 March 2012

ORIGINAL RESEARCH

Relationships between respiratory and airway resistances and activity-related dyspnea in patients with chronic obstructive pulmonary disease Mahut B, Caumont-Prim A, Plantier L, Gillet-Juvin K, Callens E, Sanchez O, Chevalier-Bidaud B, Bokov P, Delclaux C International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:165-171 Published Date: 6 March 2012

ORIGINAL RESEARCH

Safety and efficacy of dual therapy with GSK233705 and salmeterol versus monotherapy with salmeterol, tiotropium, or placebo in a crossover pilot study in partially reversible COPD patients Beier J, van Noord J, Deans A, Brooks J, Maden C, Baggen S, Mehta R, Cahn A International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:153-164 Published Date: 5 March 2012

REVIEW

Comparative efficacy of indacaterol in chronic obstructive pulmonary disease Ribeiro M, Chapman KR International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:145-152 Published Date: 5 March 2012

ORIGINAL RESEARCH

Differences in subjective and objective respiratory parameters in patients with chronic obstructive pulmonary disease with and without pain Bentsen SB, Rustøen T, Miaskowski C International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:137-143 Published Date: 28 February 2012

ORIGINAL RESEARCH

Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary note Falsey AR, Becker KL, Swinburn AJ, Nylen ES, Snider RH, Formica MA, Hennessey PA, Criddle MM, Peterson DR, Walsh EE International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:127-135 Published Date: 23 February 2012

ORIGINAL RESEARCH

Total lung capacity by plethysmography and high-resolution computed tomography in COPD Garfield JL, Marchetti N, Gaughan JP, Steiner RM, Criner GJ International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:119-126 Published Date: 22 February 2012

ORIGINAL RESEARCH

Effects of tiotropium on sympathetic activation during exercise in stable chronic obstructive pulmonary disease patients Yoshimura K, Maekura R, Hiraga T, Kitada S, Miki K, Miki M, Tateishi Y International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:109-118 Published Date: 2 May 2012

ORIGINAL RESEARCH

Guideline-based survey of outpatient COPD management by pulmonary specialists in Germany Glaab T, Vogelmeier C, Hellmann A, Buhl R International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:101-108 Published Date: 14 February 2012

REVIEW

Lung function decline in COPD Tantucci C, Modina D International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:95-99 Published Date: 9 February 2012

ORIGINAL RESEARCH

Five-year follow-up of a one-year self-management program for patients with COPD Lomundal BK, Steinsbekk A International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:87-93 Published Date: 9 February 2012

ORIGINAL RESEARCH

Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials Tashkin DP, Doherty DE, Kerwin E, Matiz-Bueno CE, Knorr B, Shekar T, Gates D, Staudinger H International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:73-86 Published Date: 3 February 2012

ORIGINAL RESEARCH

Effects of mometasone furoate/formoterol fumarate fixed-dose combination formulation on chronic obstructive pulmonary disease (COPD): results from a 52-week Phase III trial in subjects with moderate-to-very severe COPD Doherty DE, Tashkin DP, Kerwin E, Knorr BA, Shekar T, Banerjee S, Staudinger H International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:57-71 Published Date: 3 February 2012

ORIGINAL RESEARCH

Efficacy and safety of a fixed-dose combination of mometasone furoate and formoterol fumarate in subjects with moderate to very severe COPD: results from a 52-week Phase III trial Tashkin DP, Doherty DE, Kerwin E, Matiz-Bueno C, Knorr B, Shekar T, Banerjee S, Staudinger H International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:43-55 Published Date: 3 February 2012

ORIGINAL RESEARCH

Municipality screening of citizens with suspicion of chronic obstructive pulmonary disease Riegels-Jakobsen T, Skouboe M, Dollerup J, Andersen CB, Staal LB, Jakobsen RBH, Poulsen PB International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:35-41 Published Date: 1 February 2012

LETTER

Letter Laurenzi M International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:33-34 Published Date: 31 January 2012

ORIGINAL RESEARCH

Bronchoscopic thermal vapor ablation in a canine model of emphysema Tuck SA, Lopes-Berkas V, Beam S, Anderson JC International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:21-31 Published Date: 26 January 2012

ORIGINAL RESEARCH

Clinical and economic outcomes for patients initiating fluticasone propionate/salmeterol combination therapy (250/50 mcg) versus anticholinergics in a comorbid COPD/depression population Dalal AA, Shah M, D'Souza AO, Chaudhari S, Crater G International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:11-19 Published Date: 18 January 2012

ORIGINAL RESEARCH

Undertreatment of COPD: a retrospective analysis of US managed care and Medicare patients Make B, Dutro MP, Paulose-Ram R, Marton JP, Mapel DW International Journal of Chronic Obstructive Pulmonary Disease 2012, 7:1-9 Published Date: 18 January 2012

ORIGINAL RESEARCH

A pilot study of the impact of high-frequency chest wall oscillation in chronic obstructive pulmonary disease patients with mucus hypersecretion Chakravorty I, Chahal K, Austin G International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:693-699 Published Date: 14 December 2011

ORIGINAL RESEARCH

Sensitivity to environmental irritants and quality of life in COPD Ternesten-Hasséus E, Larsson S, Millqvist E International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:685-691 Published Date: 9 December 2011

ORIGINAL RESEARCH

Nutritional deficits in elderly smokers with respiratory symptoms that do not fulfill the criteria for COPD Obase Y, Mouri K, Shimizu H, Ohue Y, Kobashi Y, Kawahara K, Oka M International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:679-683 Published Date: 9 December 2011

ORIGINAL RESEARCH

Adjusting for COPD severity in database research: developing and validating an algorithm Goossens LMA, Baker CL, Monz BU, Zou KH, Rutten-van Mölken MPMH International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:669-678 Published Date: 6 December 2011

ORIGINAL RESEARCH

Why are some evidence-based care recommendations in chronic obstructive pulmonary disease better implemented than others? Perspectives of medical practitioners Johnston KN, Young M, Grimmer-Somers KA, Antic R, Frith PA International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:659-667 Published Date: 6 December 2011

ORIGINAL RESEARCH

Outcome of pulmonary rehabilitation in COPD patients with severely impaired health status van Ranst D, Otten H, Meijer JW, van 't Hul AJ International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:647-657 Published Date: 1 December 2011

ORIGINAL RESEARCH

Functional imaging using computer methods to compare the effect of salbutamol and ipratropium bromide in patient-specific airway models of COPD De Backer LA, Vos WG, Salgado R, De Backer JW, Devolder A, Verhulst SL, Claes R, Germonpré PR, De Backer WA International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:637-646 Published Date: 28 November 2011

ORIGINAL RESEARCH

Cognitive behavioral therapy for insomnia comorbid with COPD is feasible with preliminary evidence of positive sleep and fatigue effects Kapella MC, Herdegen JJ, Perlis ML, Shaver JL, Larson JL, Law JA, Carley DW International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:625-635 Published Date: 24 November 2011

ORIGINAL RESEARCH

The effects of long-term noninvasive ventilation in hypercapnic COPD patients: a randomized controlled pilot study De Backer L, Vos W, Dieriks B, Daems D, Verhulst S, Vinchurkar S, Ides K, De Backer J, Germonpre P, De Backer W International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:615-624 Published Date: 18 November 2011

REVIEW

Implementing chronic care for COPD: planned visits, care coordination, and patient empowerment for improved outcomes Fromer L International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:605-614 Published Date: 21 November 2011

ORIGINAL RESEARCH

Asthma, chronic obstructive pulmonary disease, or both? Diagnostic labeling and spirometry in primary care patients aged 40 years or more Melbye H, Drivenes E, Dalbak LG, Leinan T, Høegh-Henrichsen S, Østrem A International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:597-603 Published Date: 17 November 2011

ORIGINAL RESEARCH

Dyadic coping, quality of life, and psychological distress among chronic obstructive pulmonary disease patients and their partners Meier C, Bodenmann G, Moergeli H, Jenewein J International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:583-596 Published Date: 16 November 2011

ORIGINAL RESEARCH

Severity of COPD at initial spirometry-confirmed diagnosis: data from medical charts and administrative claims Mapel DW, Dalal AA, Blanchette CM, Petersen H, Ferguson GT International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:573-581 Published Date: 9 November 2011

ORIGINAL RESEARCH

Safety-net facilities and hospitalization rates of chronic obstructive pulmonary disease: a crosssectional analysis of the 2007 Texas Health Care Information Council inpatient data Jackson BE, Suzuki S, Coultas D, Su F, Lingineni R, Singh KP, Bartolucci A, Bae S International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:563-571 Published Date: 11 November 2011

EXPERT OPINION

Use of cluster analysis to describe desaturator phenotypes in COPD: correlations between pulmonary function tests and nocturnal oxygen desaturation Toraldo DM, De Nuccio F, Gaballo A, Nicolardi G International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:551-561 Published Date: 9 November 2011

ORIGINAL RESEARCH

Chronic airflow limitation in a rural Indian population: etiology and relationship to body mass index Chakrabarti B, Purkait S, Gun P, Moore VC, Choudhuri S, Zaman MJ, Warburton CJ, Calverley PMA, Mukherjee R International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:543-549 Published Date: 18 October 2011

ORIGINAL RESEARCH

Cost trends among commercially insured and Medicare Advantage-insured patients with chronic obstructive pulmonary disease: 2006 through 2009 Dalal AA, Liu F, Riedel AA International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:533-542 Published Date: 14 October 2011

ORIGINAL RESEARCH

Spirometry for patients in hospital and one month after admission with an acute exacerbation of COPD Rea H, Kenealy T, Adair J, Robinson E, Sheridan N International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:527-532 Published Date: 14 October 2011

ORIGINAL RESEARCH

Predictive properties of different multidimensional staging systems in patients with chronic obstructive pulmonary disease Oga T, Tsukino M, Hajiro T, Ikeda A, Nishimura K International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:521-526 Published Date: 11 October 2011

ORIGINAL RESEARCH

Factors associated with good self-rated health and quality of life in subjects with self-reported COPD Arne M, Lundin F, Boman G, Janson C, Janson S, Emtner M International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:511-519 Published Date: 7 October 2011

ORIGINAL RESEARCH

Effects of beclomethasone/formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients Tzani P, Crisafulli E, Nicolini G, Aiello M, Chetta A, Clini E, Olivieri D International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:503-509 Published Date: 4 October 2011

ORIGINAL RESEARCH

Determinants of polypharmacy and compliance with GOLD guidelines in patients with chronic obstructive pulmonary disease Franssen FME, Spruit MA, Wouters EFM International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:493-501 Published Date: 26 September 2011

ORIGINAL RESEARCH

Safety of indacaterol in the treatment of patients with COPD Donohue JF, Singh D, Kornmann O, Lawrence D, Lassen C, Kramer B International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:477-492 Published Date: 22 September 2011

ORIGINAL RESEARCH

Long-term use of fluticasone propionate/salmeterol fixed-dose combination and incidence of cataracts and glaucoma among chronic obstructive pulmonary disease patients in the UK General Practice Research Database Miller DP, Watkins SE, Sampson T, Davis KJ International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:467-476 Published Date: 16 September 2011

REVIEW

Profile of aclidinium bromide in the treatment of chronic obstructive pulmonary disease Sims MW, Panettieri, Jr. RA International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:457-466 Published Date: 16 September 2011

ORIGINAL RESEARCH

Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations Pomares X, Montón C, Espasa M, Casabon J, Monsó E, Gallego M International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:449-456 Published Date: 6 September 2011

ORIGINAL RESEARCH

Suppression of IL-8 production from airway cells by tiotropium bromide in vitro Suzaki I, Asano K, Shikama Y, Hamasaki T, Kanei A, Suzaki H International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:439-448 Published Date: 6 September 2011

ORIGINAL RESEARCH

Bronchodilator efficacy and safety of indacaterol 150 µg once daily in patients with COPD: an analysis of pooled data Bleecker ER, Siler T, Owen R, Kramer B International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:431-438 Published Date: 18 August 2011

ORIGINAL RESEARCH

Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease Furutate R, Ishii T, Wakabayashi R, Motegi T, Yamada K, Gemma A, Kida K International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:423-430 Published Date: 8 August 2011

REVIEW

Pathogenic triad in COPD: oxidative stress, protease–antiprotease imbalance, and inflammation Fischer BM, Pavlisko E, Voynow JA International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:413-421 Published Date: 5 August 2011

SHORT REPORT

Monitoring and analysis of lung sounds remotely Sahgal N International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:407-412 Published Date: 20 July 2011

ORIGINAL RESEARCH

Dose-response curve to salbutamol during acute and chronic treatment with formoterol in COPD La Piana GE, Corda L, Bertella E, Taranto Montemurro L, Pini L, Tantucci C International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:399-405 Published Date: 12 July 2011

ORIGINAL RESEARCH

Disability related to COPD tool (DIRECT): towards an assessment of COPD-related disability in routine practice Aguilaniu B, Gonzalez-Bermejo J, Regnault A, Dias Barbosa C, Arnould B, Mueser M, Granet G, Bonnefoy M, Similowski T International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:387-398 Published Date: 5 July 2011

CORRIGENDUM

Corrigendum Seemungal TA, Lun JC, Davis G, Neblett C, Chinyepi N, Dookhan C, Drakes S, Mandeville E, Nana F, Setlhake S, King CP, Pinto Pereira L, Delisle J, Wilkinson TM, Wedzicha JA International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:385-386 Published Date: 4 July 2011

METHODOLOGY

A novel study design for antibiotic trials in acute exacerbations of COPD: MAESTRAL methodology Wilson R, Anzueto A, Miravitlles M, Arvis P, Faragó G, Haverstock D, Trajanovic M, Sethi S International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:373-383 Published Date: 29 June 2011

METHODOLOGY

Clinical pathway for acute exacerbations of chronic obstructive pulmonary disease: method development and five years of experience Nishimura K, Yasui M, Nishimura T, Oga T International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:365-372 Published Date: 29 June 2011

ORIGINAL RESEARCH

Delivery characteristics and patients’ handling of two single-dose dry-powder inhalers used in COPD Chapman KR, Fogarty CM, Peckitt C, Lassen C, Jadayel D, Dederichs J, Dalvi M, Kramer B International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:353-363 Published Date: 23 June 2011

ORIGINAL RESEARCH

Haemophilus influenzae and smoking-related obstructive airways disease Otczyk DC, Clancy RL, Cripps AW International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:345-351 Published Date: 16 June 2011

REVIEW

Comparative efficacy of indacaterol 150 µg and 300 µg versus fixed-dose combinations of formoterol + budesonide or salmeterol + fluticasone for the treatment of chronic obstructive pulmonary disease – a network meta-analysis Cope S, Capkun-Niggli G, Gale R, Jardim JR, Jansen JP International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:329-344 Published Date: 8 June 2011

ORIGINAL RESEARCH

Geographic disparities in chronic obstructive pulmonary disease (COPD) hospitalization among Medicare beneficiaries in the United States Holt JB, Zhang X, Presley-Cantrell L, Croft JB International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:321-328 Published Date: 8 June 2011

ORIGINAL RESEARCH

Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process Geraghty P, Wallace A, D'Armiento J International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:309-319 Published Date: 2 June 2011

ORIGINAL RESEARCH

Measuring the impact of a live, case-based, multiformat, interactive continuing medical education program on improving clinician knowledge and competency in evidence-based COPD care Drexel C, Jacobson A, Hanania NA, Whitfield B, Katz J, Sullivan T International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:297-307 Published Date: 23 May 2011

REVIEW

Role of clinical questionnaires in optimizing everyday care of chronic obstructive pulmonary disease Jones PW, Price D, van der Molen T International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:289-296 Published Date: 26 May 2011

ORIGINAL RESEARCH

Effect of gene environment interactions on lung function and cardiovascular disease in COPD Hackett TL, Stefanowicz D, Aminuddin F, Sin DD, Connett JE, Anthonisen NR, Paré PD, Sandford AJ International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:277-287 Published Date: 10 May 2011

ORIGINAL RESEARCH

Tiotropium reduces risk of exacerbations irrespective of previous use of inhaled anticholinergics in placebo-controlled clinical trials Cooper CB, Anzueto A, Decramer M, Celli B, Tashkin DP, Leimer I, Kesten S International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:269-275 Published Date: 9 May 2011

REVIEW

Improved patient outcome with smoking cessation: when is it too late? Wu J, Sin DD International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:259-267 Published Date: 2 May 2011

ORIGINAL RESEARCH

Long-term survival in elderly patients with a do-not-intubate order treated with noninvasive mechanical ventilation Scarpazza P, Incorvaia C, Amboni P, di Franco G, Raschi S, Usai P, Bernareggi M, Bonacina C, Melacini C, Cattaneo R, Bencini S, Pravettoni C, Riario-Sforza GG, Passalacqua G, Casali W International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:253-257 Published Date: 26 April 2011

ORIGINAL RESEARCH

Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD Hodder R, Pavia D, Lee A, Bateman E International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:245-251 Published Date: 26 April 2011

REVIEW

Long-acting ß-adrenoceptor agonists in the management of COPD: focus on indacaterol Beier J, Beeh KM International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:237-243 Published Date: 12 April 2011

ORIGINAL RESEARCH

Bronchodilation improves endurance but not muscular efficiency in chronic obstructive pulmonary disease van der Vaart H, Postma DS, Grevink R, Roemer W, ten Hacken NHT International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:229-235 Published Date: 8 April 2011

ORIGINAL RESEARCH

Comparison of efficacy of long-acting bronchodilators in emphysema dominant and emphysema nondominant chronic obstructive pulmonary disease Fujimoto K, Kitaguchi Y, Kanda S, Urushihata K, Hanaoka M, Kubo K International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:219-227 Published Date: 1 April 2011

ORIGINAL RESEARCH

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences Viktor M Pastukh, Li Zhang, Mykhaylo V Ruchko, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:209-217 Published Date: 13 March 2011

REVIEW

Hypoxemia in patients with COPD: cause, effects, and disease progression Brian D Kent, Patrick D Mitchell, Walter T McNicholas International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:199-208 Published Date: 14 March 2011

PERSPECTIVES

Lung injury after cigarette smoking is particle related Rahul G Sangani, Andrew J Ghio International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:191-198 Published Date: 10 March 2011

ORIGINAL RESEARCH

Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes Hironori Masuko, Tohru Sakamoto, Shiko Kaneko, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:181-189 Published Date: 2 March 2011

ORIGINAL RESEARCH

Barriers to adherence to chronic obstructive pulmonary disease guidelines by primary care physicians Gregory D Salinas, James C Williamson, Ravi Kalhan, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:171-179 Published Date: 28 February 2011

ORIGINAL RESEARCH

Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease Alicia Lacoma, Cristina Prat, Felipe Andreo, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:157-169 Published Date: 28 February 2011

REVIEW

New therapeutic options in the management of COPD – focus on roflumilast Sabina Antonela Antoniu International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:147-155 Published Date: 17 February 2011

REVIEW

Spirometric testing on World COPD Day Tanja Grzetic-Romcevic, Boris Devcic, Silvana Sonc, International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:141-146 Published Date: 10 February 2011

REVIEW

Clinical effectiveness of the Respimat® inhaler device in managing chronic obstructive pulmonary disease: evidence when compared with other handheld inhaler devices Felix SF Ram, Celso R Carvallho, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:129-139 Published Date: 2 February 2011

ORIGINAL RESEARCH

Early detection of COPD in general practice Charlotte Suppli Ulrik, Anders Løkke, Ronald Dahl, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:123-127 Published Date: 28 January 2011

REVIEW

Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer Seyed Javad Moghaddam, Cesar E Ochoa, Sanjay Sethi, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:113-123 Published Date: 27 January 2011

ORIGINAL RESEARCH

Components of physical capacity in patients with chronic obstructive pulmonary disease: relationship with phenotypic expression Eduardo Márquez-Martín, Pilar Cejudo Ramos, José Luis López-Campos, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:105-112 Published Date: 26 January 2011

ORIGINAL RESEARCH

Relationships between repeated instruction on inhalation therapy, medication adherence, and health status in chronic obstructive pulmonary disease Masaya Takemura, Katsumi Mitsui, Ryo Itotani, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:97-104 Published Date: 20 January 2011

ORIGINAL RESEARCH

Prevalence and risk factors for unrecognized obstructive lung disease among urban drug users M Bradley Drummond, Gregory D Kirk, Jacquie Astemborski, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:89-95 Published Date: 19 January 2011

ORIGINAL RESEARCH

A gender difference in circulating neutrophils in malnourished patients with COPD Sven Larsson, Anita Nordenson, Pernilla Glader, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:83-88 Published Date: 17 January 2011

ORIGINAL RESEARCH

Economic burden of chronic bronchitis in the United States: a retrospective case-control study Christopher M Blanchette, Melissa H Roberts, Hans Petersen, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:73-81 Published Date: 13 January 2011

ORIGINAL RESEARCH

Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema João Tadeu Ribeiro-Paes, Aldemir Bilaqui, Oswaldo T Greco, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:63-71 Published Date: 12 January 2011

REVIEW

Optimizing management of chronic obstructive pulmonary disease in the upcoming decade Richard Russell, Antonio Anzueto, Idelle Weisman International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:47-61 Published Date: 10 January 2011

REVIEW

Changing patterns in long-acting bronchodilator trials in chronic obstructive pulmonary disease James F Donohue, Paul W Jones International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:35-45 Published Date: 7 January 2011

SHORT REPORT

Vitamin D and responses to inhaled fluticasone in severe chronic obstructive pulmonary disease Ken M Kunisaki, Thomas S Rector International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:29-34 Published Date: 7 January 2011

ORIGINAL RESEARCH

Fractal correlation property of heart rate variability in chronic obstructive pulmonary disease Tatiana D Carvalho, Carlos Marcelo Pastre, Moacir Fernandes de Godoy, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:23-28 Published Date: 6 January 2011

ORIGINAL RESEARCH

Comparative cost-effectiveness of a fluticasone-propionate/salmeterol combination versus anticholinergics as initial maintenance therapy for chronic obstructive pulmonary disease Anand A Dalal, Melissa H Roberts, Hans V Petersen, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:13-22 Published Date: 31 December 2010

ORIGINAL RESEARCH

Sleep quality predicts quality of life in chronic obstructive pulmonary disease Steven M Scharf, Nimrod Maimon, Tzahit Simon-Tuval, et al International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:1-12 Published Date: 22 December 2010

ORIGINAL RESEARCH

Association between lung function and exacerbation frequency in patients with COPD Martine Hoogendoorn, Talitha L Feenstra, Rudolf T Hoogenveen, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:435-444 Published Date: 9 December 2010

ORIGINAL RESEARCH

Validation of alternate modes of administration of the lung function questionnaire (LFQ) in subjects with smoking history Anand A Dalal, Carla DeMuro-Mercon, Sandy Lewis, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:425-434 Published Date: 7 December 2010

ORIGINAL RESEARCH

In search of parsimony: reliability and validity of the Functional Performance Inventory-Short Form Nancy Kline Leidy, Ann Knebel International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:415-423 Published Date: 25 November 2010

REVIEW

Sustained effects of integrated COPD management on health status and exercise capacity in primary care patients Annemarije L Kruis, Joan van Adrichem, Magda R Erkelens, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:407-413 Published Date: 25 November 2010

REVIEW

Improving adherence with inhaler therapy in COPD Suzanne C Lareau, Barbara P Yawn International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:401-406 Published Date: 24 November 2010

CASE SERIES

Cardiac injury in patients with COPD presenting with dyspnea: a pilot study Esosa Odigie-Okon, Bryan Jordan, Sylvester Dijeh, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:395-399 Published Date: 9 November 2010

ORIGINAL RESEARCH

Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors José Luis Izquierdo, Arturo Martínez, Elizabet Guzmán, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:387-394 Published Date: 8 November 2010

ORIGINAL RESEARCH

Development and implementation of treadmill exercise testing protocols in COPD Christopher B Cooper, Marlon Abrazado, Daniel Legg, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:375-385 Published Date: 12 October 2010

ORIGINAL RESEARCH

Tiotropium Respimat® improves physical functioning in chronic obstructive pulmonary disease Heike Rau-Berger, Harald Mitfessel, Thomas Glaab International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:367-373 Published Date: 10 October 2010

REVIEW

Budesonide/formoterol combination in COPD: a US perspective Amir Sharafkhaneh, Amarbir S Mattewal, Vinu M Abraham, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:357-366 Published Date: 4 October 2010

ORIGINAL RESEARCH

COPD is frequent in conditions of comorbidity in patients treated with various diseases in a university hospital Akira Yamasaki, Kiyoshi Hashimoto, Yasuyuki Hasegawa, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:351-355 Published Date: 29 September 2010

ORIGINAL RESEARCH

Direct costs of chronic obstructive pulmonary disease among managed care patients Anand A Dalal, Laura Christensen, Fang Liu, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:341-349 Published Date: 30 September 2010

ORIGINAL RESEARCH

Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease Davood Attaran, Shahrzad M Lari, Mohammad Towhidi, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:335-340 Published Date: 30 September 2010

ORIGINAL RESEARCH

Assessment of airway inflammation using sputum, BAL, and endobronchial biopsies in current and ex-smokers with established COPD Yudong Wen, David W Reid, Dongcheng Zhang, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:327-334 Published Date: 28 September 2010

SHORT REPORT

Fatigue in patients with COPD participating in a pulmonary rehabilitation program Cindy J Wong, Donna Goodridge, Darcy D Marciniuk, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:319-326 Published Date: 13 September 2010

ORIGINAL RESEARCH

Onset of action of indacaterol in patients with COPD: Comparison with salbutamol and salmeterol-fluticasone Beatrix Balint, Henrik Watz, Carolynn Amos, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:311-318 Published Date: 6 September 2010

REVIEW

Glucocorticoid insensitivity as a future target of therapy for chronic obstructive pulmonary disease John A Marwick, Kian Fan Chung International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:297-309 Published Date: 1 September 2010

ORIGINAL RESEARCH

Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice Efrossini Dima, Nikoletta Rovina, Christina Gerassimou, et al. International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:287-296 Published Date: 2 September 2010

ORIGINAL RESEARCH

Tiotropium bromide inhibits TGF-ß-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro Kazuhito Asano, Yusuke Shikama, Naruo Shoji, et al. International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:277-286 Published Date: 30 August 2010

ORIGINAL RESEARCH

A validated disease specific prediction equation for resting metabolic rate in underweight patients with COPD Anita Nordenson, Anne Marie Grönberg, Lena Hulthén, et al. International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:271-276 Published Date: 1 September 2010

ORIGINAL RESEARCH

COPD and cognitive impairment: the role of hypoxemia and oxygen therapy Neeta Thakur, Paul D Blanc, Laura J Julian, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:263-269 Published Date: 10 August 2010

ORIGINAL RESEARCH

Inspiratory flows through dry powder inhaler in chronic obstructive pulmonary disease: age and gender rather than severity matters L Pekka Malmberg, Paula Rytilä, Pertti Happonen, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:257-262 Published Date: 4 August 2010

ORIGINAL RESEARCH

Clinical efficacy of farcosolvin syrup (ambroxol–theophylline–guaiphenesin mixture) in the treatment of acute exacerbation of chronic bronchitis Mostafa Yakoot, Amel Salem, Abdel-Mohsen Omar International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:251-256 Published Date: 20 July 2010

ORIGINAL RESEARCH

Misdiagnosis of patients receiving inhaled therapies in primary care José Luis Izquierdo, Antonio Martín, Pilar de Lucas, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:241-249 Published Date: 14 July 2010

ORIGINAL RESEARCH

Lung function and blood markers of nutritional status in non-COPD aging men with smoking history: A cross-sectional study Nobuyoshi Shiozawa, Kanae Hayashimoto, Etsuji Suzuki, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:233-240 Published Date: 7 July 2010

REVIEW

Nebulized formoterol: a review of clinical efficacy and safety in COPD Nicholas J Gross, James F Donohue International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:223-232 Published Date: 28 June 2010

ORIGINAL RESEARCH

Tumor necrosis factor- serum levels in healthy smokers and nonsmokers Florin Petrescu, Sebastian Cosmin Voican, Isabela Silosi International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:217-222 Published Date: 7 July 2010

ORIGINAL RESEARCH

Changes in six-minute walking distance during pulmonary rehabilitation in patients with COPD and in healthy subjects Imen Ben Cheikh Rejbi, Yassine Trabelsi, Afef Chouchene, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:209-215 Published Date: 7 July 2010

ORIGINAL RESEARCH

Efficacy and safety of tiotropium Respimat® SMI in COPD in two 1-year randomized studies Eric Bateman, Dave Singh, David Smith, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:197-208 Published Date: 9 June 2010

REVIEW

An overview of the benefits and drawbacks of inhaled corticosteroids in chronic obstructive pulmonary disease Sonal Singh, Yoon K Loke International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:189-195 Published Date: 17 June 2010

ORIGINAL RESEARCH

Cost-effectiveness of combination fluticasone propionate–salmeterol 250/50 µg versus salmeterol in severe COPD patients Anand A Dalal, Meaghan St Charles, Hans V Petersen, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:179-187 Published Date: 9 June 2010

REVIEW

The role of fluticasone propionate/salmeterol combination therapy in preventing exacerbations of COPD Barbara P Yawn, Ibrahim Raphiou, Judith S Hurley, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:165-178 Published Date: 1 June 2010

REVIEW

Influencing the decline of lung function in COPD: use of pharmacotherapy Ekaterina S Gladysheva, Atul Malhotra, Robert L Owens International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:153-164 Published Date: 17 May 2010

ORIGINAL RESEARCH

A day at a time: caregiving on the edge in advanced COPD A Catherine Simpson, Joanne Young, Margaret Donahue, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:141-151 Published Date: 10 May 2010

ORIGINAL RESEARCH

Modified BODE indexes: Agreement between multidimensional prognostic systems based on oxygen uptake José Luis Lopez-Campos, Pilar Cejudo, Eduardo Marquez, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:133-140 Published Date: 4 May 2010

ORIGINAL RESEARCH

Burden of COPD in a government health care system: a retrospective observational study using data from the US Veterans Affairs population Amir Sharafkhaneh, Nancy J Petersen, Hong-Jen Yu, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:125-132 Published Date: 22 April 2010

ORIGINAL RESEARCH

Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation Voicu Tudorache, Cristian Oancea, Ovidiu Fira Mlădinescu International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:119-123 Published Date: 22 April 2010

ORIGINAL RESEARCH

Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids Violetta M Piotrowska, Wojciech J Piotrowski, Zofia Kurmanowska, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:107-117 Published Date: 20 April 2010

ORIGINAL RESEARCH

Factors associated with opioid dispensation for patients with COPD and lung cancer in the last year of life: A retrospective analysis Donna Goodridge, Josh Lawson, Graeme Rocker, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:99-105 Published Date: 15 April 2010

ORIGINAL RESEARCH

Health care utilization history, GOLD guidelines, and respiratory medication prescriptions in patients with COPD Joseph Seaman, Anthony C Leonard, Ralph J Panos International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:89-97 Published Date: 31 March 2010

REVIEW

Potential role of stem cells in management of COPD Tillie L Hackett, Darryl A Knight, Don D Sin International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:81-88 Published Date: 26 March 2010

ORIGINAL RESEARCH

Management of COPD in general practice in Denmark – participating in an educational program substantially improves adherence to guidelines Charlotte Suppli Ulrik, Ejvind Frausing Hansen, Michael Skov Jensen, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:73-79 Published Date: 11 March 2010

REVIEW

Impact of bronchodilator therapy on exercise tolerance in COPD B Aguilaniu International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:57-71 Published Date: 9 March 2010

OTHER

Noninvasive ventilation: has Pandora’s box been opened? Ari Manuel, Richard EK Russell, Quentin Jones International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:55-56 Published Date: 24 February 2010

REVIEW

Preventing and managing exacerbations in COPD – critical appraisal of the role of tiotropium Donald P Tashkin International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:41-53 Published Date: 18 February 2010

ORIGINAL RESEARCH

Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, Creactive protein and tissue hypoxia Simonetta Baldi, Roberto Aquilani, Gian Domenico Pinna, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:29-39 Published Date: 17 February 2010

ORIGINAL RESEARCH

Event-related evoked potentials in chronic respiratory encephalopathy A R Al Tahan, R Zaidan, S Jones, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:21-27 Published Date: 5 February 2010

ORIGINAL RESEARCH

Antibiotic treatment of exacerbations of COPD in general practice: long-term impact on healthrelated quality of life Marc Miravitlles, Carles Llor, Jesús Molina, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:11-19 Published Date: 15 January 2010

ORIGINAL RESEARCH

Development of the Lung Function Questionnaire (LFQ) to identify airflow obstruction Barbara P Yawn, Douglas W Mapel, David M Mannino, et al International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:1-10 Published Date: 17 December 2009

ORIGINAL RESEARCH

Alpha-1-antitrypsin augmentation therapy in deficient individuals enrolled in the Alpha-1 Foundation DNA and Tissue Bank Adriano R Tonelli, Farshid Rouhani, Ning Li, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:443-452 Published Date: 8 December 2009

ORIGINAL RESEARCH

Can dead space fraction predict the length of mechanical ventilation in exacerbated COPD patients? Raymond Farah, Nicola Makhoul International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:437-441 Published Date: 25 November 2009

ORIGINAL RESEARCH

Predictive value and utility of oral steroid testing for treatment of COPD in primary care: the COOPT study Niels H Chavannes, Tjard RJ Schermer, Emiel FM Wouters, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:431-436 Published Date: 19 November 2009

REVIEW

Clinical utility of varenicline for smokers with medical and psychiatric comorbidity Jon O Ebbert, Kirk D Wyatt, Ali Zirakzadeh, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:421-430 Published Date: 17 November 2009

REVIEW

The pathophysiology of bronchiectasis Paul T King International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:411-419 Published Date: 30 October 2009

REVIEW

Tiotropium HandiHaler® in the treatment of COPD: A safety review Steven Kesten, Bart Celli, Marc Decramer, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:397-409 Published Date: 28 October 2009

ORIGINAL RESEARCH

Sequential comparison of tiotropium to high-dose ipratropium in patients with chronic obstructive pulmonary disease in a practice setting Umair Gauhar, Mark Dransfield, J Allen D Cooper International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:391-395 Published Date: 14 October 2009

REVIEW

Patient preferences for inhaler devices in chronic obstructive pulmonary disease: experience with Respimat® Soft Mist™ Inhaler Richard Hodder, David Price International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:381-390 Published Date: 14 October 2009

REVIEW

Long-term therapy in COPD: any evidence of adverse effect on bone? Arnulf Langhammer, Siri Forsmo, Unni Syversen International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:365-380 Published Date: 30 September 2009

REVIEW

Update on pulmonary hypertension complicating chronic obstructive pulmonary disease Soma Jyothula, Zeenat Safdar International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:351-363 Published Date: 8 September 2009

ORIGINAL RESEARCH

Chronic obstructive pulmonary disease as an independent risk factor for cardiovascular morbidity Joseph Finkelstein, Eunme Cha, Steven M Scharf International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:337-349 Published Date: 4 September 2009

REVIEW

Targeted treatment in COPD: a multi-system approach for a multi-system disease David Anderson, William MacNee International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:321-335 Published Date: 31 August 2009

ORIGINAL RESEARCH

Effects of pulmonary rehabilitation on exercise capacity in patients with COPD: A number needed to treat study Gian Galeazzo Riario-Sforza, Cristoforo Incorvaia, Fulvia Paterniti, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:315-319 Published Date: 21 August 2009

ORIGINAL RESEARCH

Pilot study of a cell phone-based exercise persistence intervention post-rehabilitation for COPD Huong Q Nguyen, Dawn P Gill, Seth Wolpin, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:301-313 Published Date: 5 August 2009

REVIEW

Gemifloxacin use in the treatment of acute bacterial exacerbation of chronic bronchitis Cristian Jivcu, Mark Gotfried International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:291-300 Published Date: 31 July 2009

OTHER

ICS and COPD: Time to clear the air Paul A Ford, Richard EK Russell, Peter J Barnes International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:289-290 Published Date: 31 July 2009

REVIEW

Management of invasive aspergillosis in patients with COPD: rational use of voriconazole Florence Ader, Anne-Lise Bienvenu, Blandine Rammaert, et al. International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:279-287 Published Date: 24 July 2009

ORIGINAL RESEARCH

The relationship between adipokines, body composition, and bone density in men with chronic obstructive pulmonary disease Sheryl F Vondracek, Norbert F Voelkel, Michael T McDermott, Connie Valdez International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:267-277 Published Date: 13 July 2009

OTHER

Impact factor and its role in academic promotion Richard Russell, Dave Singh International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:265-266 Published Date: 16 July 2009

REVIEW

A systematic review of the cardiovascular risk of inhaled anticholinergics in patients with COPD Daniel E Hilleman, Mark A Malesker, Lee E Morrow, Dan Schuller International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:253-263 Published Date: 30 June 2009

ORIGINAL RESEARCH

Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes A Anzueto, I Leimer, S Kesten International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:245-251 Published Date: 24 June 2009

REVIEW

Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease Sean H Ling, Stephan F van Eeden International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:233-243 Published Date: 10 June 2009

REVIEW

Asthma patients prefer Respimat® Soft Mist™ Inhaler to Turbuhaler® Rick Hodder, Pat Ray Reese, Terra Slaton International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:225-232 Published Date: 26 May 2009

REVIEW

Exacerbation rate, health status and mortality in COPD – a review of potential interventions Terence AR Seemungal, John R Hurst, Jadwiga A Wedzicha International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:203-223 Published Date: 29 May 2009

REVIEW

Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT® studies Marc Miravitlles, Antonio Anzueto International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:185-201 Published Date: 8 May 2009

ORIGINAL RESEARCH

Beta-blockers and health-related quality of life in patients with peripheral arterial disease and COPD Yvette RBM van Gestel, Sanne E Hoeks, Don D Sin, Henk Stam, Frans W Mertens, Jeroen J Bax, Ron T van Domburg, Don Poldermans International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:177-183 Published Date: 8 May 2009

ORIGINAL RESEARCH

The impact of SHS exposure on health status and exacerbations among patients with COPD Mark D Eisner, Carlos Iribarren, Edward H Yelin, Stephen Sidney, et al. International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:169-176 Published Date: 6 May 2009

REVIEW

Markers of early disease and prognosis in COPD Morten Dahl, Børge G Nordestgaard International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:157-167 Published Date: 7 April 2009

ORIGINAL RESEARCH

The repeatability of interleukin-6, tumor necrosis factor- , and C-reactive protein in COPD patients over one year Umme Kolsum, Kay Roy, Cerys Starkey, Zoë Borrill, Nick Truman, Jørgen Vestbo, Dave Singh International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:149-156 Published Date: 3 April 2009

ORIGINAL RESEARCH

Life expectancy and years of life lost in chronic obstructive pulmonary disease: Findings from the NHANES III Follow-up Study Robert M Shavelle, David R Paculdo, Scott J Kush, David M Mannino, David J Strauss International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:137-148 Published Date: 18 March 2009

ORIGINAL RESEARCH

Reticular basement membrane in asthma and COPD: Similar thickness, yet different composition Jeroen JW Liesker, Nick H Ten Hacken, Mieke Zeinstra-Smith, Steven R Rutgers, Dirkje S Postma, et al. International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:127-135 Published Date: 26 February 2009

ORIGINAL RESEARCH

Study design considerations in a large COPD trial comparing effects of tiotropium with salmeterol on exacerbations Kai-Michael Beeh, Bettina Hederer, Thomas Glaab, Achim Müller, Maureen Rutten-van Moelken, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:119-125 Published Date: 26 February 2009

ORIGINAL RESEARCH

Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease Felix C Ringshausen, Ai-Yui M Tan, Tobias Allander, Irmgard Borg, Umut Arinir, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:111-117 Published Date: 4 February 2009

ORIGINAL RESEARCH

Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation Erik Bathoorn, Jeroen JW Liesker, Dirkje S Postma, Gerard H Koëter, Marco van der Toorn, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:101-109 Published Date: 2 February 2009

REVIEW

Identifying potentially cost effective chronic care programs for people with COPD L M G Steuten, K M M Lemmens, A P Nieboer, H JM Vrijhoef International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:87-100 Published Date: 22 December 2008

ORIGINAL RESEARCH

Measurement of tumor necrosis factor- , leukotriene B4, and interleukin 8 in the exhaled breath condensate in patients with acute exacerbations of chronic obstructive pulmonary disease Fanny WS Ko, Ting-Fan Leung, Gary WK Wong, Jenny Ngai, Kin W To, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:79-86 Published Date: 10 December 2008

REVIEW

Focusing on outcomes: Making the most of COPD interventions Noreen M Clark, Julia A Dodge, Martyn R Partridge, Fernando J Martinez International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:61-77 Published Date: 7 October 2008

ORIGINAL RESEARCH

Early discharge care with ongoing follow-up support may reduce hospital readmissions in COPD Maria Lawlor, Sinead Kealy, Michelle Agnew, Bettina Korn, Jennifer Quinn, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:55-60 Published Date: 30 October 2008

ORIGINAL RESEARCH

Efficacy of amoxycillin versus amoxycillin/clavulanate in acute exacerbations of chronic pulmonary obstructive disease in primary care Carl Llor, Silvia Hernández, Anna Ribas, Carmen Álvarez, Josep Maria Cots, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:45-53 Published Date: 15 October 2008

ORIGINAL RESEARCH

Desensitization to dyspnea in COPD with specificity for exercise training mode Christopher B Cooper International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:33-43 Published Date: 28 September 2008

REVIEW

Alveolar epithelial and endothelial cell apoptosis in emphysema: What we know and what we need to know Mathieu C Morissette, Julie Parent, Julie Milot International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:19-31 Published Date: 2 December 2008

ORIGINAL RESEARCH

Validity, reliability, and responsiveness of a new short Visual Simplified Respiratory Questionnaire (VSRQ©) for health-related quality of life assessment in chronic obstructive pulmonary disease T Perez, B Arnould, J-M Grosbois, V Bosch, I Guillemin, et al International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:9-18 Published Date: 11 December 2008

ORIGINAL RESEARCH

Effects of singing classes on pulmonary function and quality of life of COPD patients Amanda Gimenes Bonilha, Fernanda Onofre, Maria Lucia Vieira, Maria Yuka Almeida Prado, José Antônio Baddini Martinez International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:1-8 Published Date: 2 December 2008

ORIGINAL RESEARCH

Geographic differences in clinical characteristics and management of COPD: the EPOCA study Marc Miravitlles, Cristina Murio, Gema Tirado-Conde, Gur Levy, Hana Muellerova, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:803-814 Published Date: 5 December 2008

ORIGINAL RESEARCH

Effect of noninvasive mechanical ventilation in elderly patients with hypercapnic acute-onchronic respiratory failure and a do-not-intubate order Paolo Scarpazza, Cristoforo Incorvaia, Giuseppe di Franco, Stefania Raschi, Pierfranco Usai, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:797-801 Published Date: 5 December 2008

ORIGINAL RESEARCH

Self efficacy measurement and goal attainment after pulmonary rehabilitation Rachel Garrod, Johanna Marshall, Fiona Jones International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:791-796 Published Date: 5 December 2008

ORIGINAL RESEARCH

Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro Kazuhito Asano, Yusuke Shikama, Yasuhiro Shibuya, Hiroaki Nakajima, Ken-ichi Kanai, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:781-790 Published Date: 5 December 2008

ORIGINAL RESEARCH

Tiotropium and exercise training in COPD patients: Effects on dyspnea and exercise tolerance Nicolino Ambrosino, Katia Foglio, Gianni Balzano, Pier Luigi Paggiaro, Patrizia Lessi, Steven Kesten International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:771-780 Published Date: 5 December 2008

ORIGINAL RESEARCH

Higher lung deposition with Respimat® Soft Mist™ Inhaler than HFA-MDI in COPD patients with poor technique Peter Brand, Bettina Hederer, George Austen, Helen Dewberry, Thomas Meyer International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:763-770 Published Date: 5 December 2008

ORIGINAL RESEARCH

Caregivers for people with end-stage lung disease: Characteristics and unmet needs in the whole population David C Currow, Alicia Ward, Katie Clark, Catherine M Burns, Amy P Abernethy International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:753-762 Published Date: 5 December 2008

ORIGINAL RESEARCH

C-reactive protein correlates with tissue oxygen availability in patients with stable COPD Simonetta Baldi, Gian Domenico Pinna1 Piera Mombaruzzo, Milena Biglieri, Angelo De Martini, Paolo Palange International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:745-751 Published Date: 5 December 2008

ORIGINAL RESEARCH

Noninvasive positive pressure ventilation in acute respiratory failure due to COPD vs other causes: Effectiveness and predictors of failure in a respiratory ICU in North India Ritesh Agarwal, Rajesh Gupta, Ashutosh N Aggarwal, Dheeraj Gupta International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:737-743 Published Date: 5 December 2008

ORIGINAL RESEARCH

Mental disorders and quality of life in COPD patients and their spouses Kerstin Kühl, Wolfgang Schürmann, Winfried Rief International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:727-736 Published Date: 5 December 2008

ORIGINAL RESEARCH

Pulmonary and systemic hepatocyte and keratinocyte growth factors in patients with chronic obstructive pulmonary disease Jaume Sauleda, Aina Noguera, David Blanquer, Jaume Pons, Meritxell López, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:719-725 Published Date: 5 December 2008

ORIGINAL RESEARCH

Impact of social support and self-efficacy on functioning in depressed older adults with chronic obstructive pulmonary disease Patricia Marino, Jo Anne Sirey, Patrick J Raue, George S Alexopoulos International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:713-718 Published Date: 5 December 2008

ORIGINAL RESEARCH

Determinants and predictors of the cost of COPD in primary care: A Spanish perspective Javier de Miguel Diez, Pilar Carrasco Garrido, Marta García Carballo, Angel Gil de Miguel, Javier Rejas Gutierrez, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:701-712 Published Date: 5 December 2008

OTHER

Diagnostic value of post-bronchodilator pulmonary function testing to distinguish between stable, moderate to severe COPD and asthma Daphne C Richter, James R Joubert, Haylene Nell, Mace M Schuurmans, Elvis M Irusen International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:693-699 Published Date: 5 December 2008

ORIGINAL RESEARCH

Health-related quality of life in outpatients with COPD in daily practice: the VICE Spanish study Antonio Martín, José M Rodríguez-González Moro, José L Izquierdo, Elena Gobartt, Pilar de Lucas, The VICE Study Group International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:683-692 Published Date: 5 December 2008

REVIEW

Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences Carlos Zamarrón, Vanesa García Paz, Emilio Morete, Felix del Campo Matías International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:671-682 Published Date: 5 December 2008

REVIEW

The role for S-carboxymethylcysteine (carbocisteine) in the management of chronic obstructive pulmonary disease C Hooper, J Calvert International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:659-669 Published Date: 5 December 2008

REVIEW

Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease Ho Cheol Kim, Mahroo Mofarrahi, Sabah NA Hussain International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:637-658 Published Date: 5 December 2008

REVIEW

Lung volume reduction surgery and lung transplantation in chronic obstructive pulmonary disease Jorge I Mora, Denis Hadjiliadis International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:629-635 Published Date: 5 December 2008

REVIEW

Pathophysiological roles of microvascular alterations in pulmonary inflammatory diseases: possible implications of tumor necrosis factor-alpha and CXC chemokines Kanami Orihara, Akio Matsuda International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:619-627 Published Date: 5 December 2008

REVIEW

Treatment of respiratory failure in COPD Stephan Budweiser, Rudolf A Jörres, Michael Pfeifer International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:605-618 Published Date: 5 December 2008

REVIEW

Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: Current and future perspectives Noora Louhelainen, Marjukka Myllärniemi, Irfan Rahman, Vuokko L Kinnula International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:585-603 Published Date: 5 December 2008

REVIEW

Safety, tolerability and risk benefit analysis of tiotropium in COPD Yuji Oba, Tareq Zaza, Danish M Thameem International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:575-584 Published Date: 5 December 2008

REVIEW

Treatment of mild chronic obstructive pulmonary disease Alex Chee, Don D Sin International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:563-573 Published Date: 5 December 2008

REVIEW

ABCD of the phosphodiesterase family: interaction and differential activity in COPD David MG Halpin International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:543-561 Published Date: 5 December 2008

REVIEW

Role of T-lymphocytes and pro-inflammatory mediators in the pathogenesis of chronic obstructive pulmonary disease Aneal Gadgil, Steven R Duncan International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:531-541 Published Date: 5 December 2008

REVIEW

Long-acting 2-agonists (LABA) in chronic obstructive pulmonary disease: efficacy and safety Andrea Rossi, Sonia Khirani, Mario Cazzola International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:521-529 Published Date: 5 December 2008

REVIEW

Use of azithromycin in the treatment of acute exacerbations of COPD Aaron P Milstone International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:515-520 Published Date: 5 December 2008

REVIEW

Tissue regeneration as next-generation therapy for COPD – potential applications Shunsuke Ohnishi, Noritoshi Nagaya International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:509-514 Published Date: 5 December 2008

REVIEW

Health literacy in COPD Nicola J Roberts, Ramesh Ghiassi, Martyn R Partridge International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:499-507 Published Date: 5 December 2008

OTHER

Gene-environment interactions in chronic obstructive pulmonary disease Nestor A Molfino, Anthony J Coyle International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:491-497 Published Date: 12 September 2008

ORIGINAL RESEARCH

Socioeconomic gradients in tiotropium use among adults with COPD Paul D Blanc, Mark D Eisner, Edward H Yelin, Gillian Earnest, John R Balmes, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:483-490 Published Date: 12 September 2008

RAPID COMMUNICATION

Preferential recruitment of neutrophils by endothelin-1 in acute lung inflammation induced by lipopolysaccharide or cigarette smoke Tapan Bhavsar, Xing Jian Liu, Hardik Patel, Ralph Stephani, Jerome O Cantor International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:477-481 Published Date: 12 September 2008

ORIGINAL RESEARCH

Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells Margaretha van der Deen, Sandra Homan, Hetty Timmer-Bosscha, Rik J Scheper, Wim Timens, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:469-475 Published Date: 12 September 2008

ORIGINAL RESEARCH

Role of bacteria in acute exacerbations of chronic obstructive pulmonary disease Levent Erkan, Oguz Uzun, Serhat Findik, Didem Katar, Ahmet Sanic, Atilla G Atici International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:463-467 Published Date: 12 September 2008

ORIGINAL RESEARCH

Mechanisms of improvement of respiratory failure in patients with COPD treated with NIV Annabel H Nickol, Nicholas Hart, Nicholas S Hopkinson, Carl-Hugo Hamnegård, John Moxham, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:453-462 Published Date: 12 September 2008

ORIGINAL RESEARCH

Systemic impairment in relation to disease burden in patients with moderate COPD eligible for a lifestyle program. Findings from the INTERCOM trial Carel R van Wetering, Floortje E van Nooten, Stijn J M Mol, Martine Hoogendoorn, Maureen P M H Rutten-van Mölken, Annemie M Schols International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:443-451 Published Date: 12 September 2008

ORIGINAL RESEARCH

Validation of a novel device to objectively measure adherence to long-term oxygen therapy Sun-Kai V Lin, Daniel K Bogen, Samuel T Kuna International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:435-442 Published Date: 12 September 2008

ORIGINAL RESEARCH

Modeling the impact of COPD on the brain Soo Borson, James Scanlan, Seth Friedman, Elizabeth Zuhr, Julie Fields, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:429-434 Published Date: 12 September 2008

OTHER

Benefits of short inspiratory muscle training on exercise capacity, dyspnea, and inspiratory fraction in COPD patients Barakat Shahin, Michele Germain, Alzahouri Kazem, Guy Annat International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:423-427 Published Date: 12 September 2008

OTHER

Patient identified needs for chronic obstructive pulmonary disease versus billed services for care received Jill Heins-Nesvold, Angeline Carlson, Leslie King-Schultz, Kenneth E Joslyn International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:415-421 Published Date: 12 September 2008

ORIGINAL RESEARCH

Chronic respiratory effect of narguileh smoking compared with cigarette smoking in women from the East Mediterranean region Yousser Mohammad, Mouna Kakah, Yasser Mohammad International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:405-414 Published Date: 12 September 2008

ORIGINAL RESEARCH

Pharmacokinetics and tolerability (Study 1) with particular reference to ocular safety (Study 2) of tiotropium Respimat® Soft Mist™ Inhaler: findings from two dose-ranging studies in healthy men Ulrich Feifel, Gudrun Wallenstein, Karl-Ludwig Rominger, Dirk Trommeshauser, Juliane Platz International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:397-403 Published Date: 12 September 2008

REVIEW

The precarious balance between ‘supply’ and ‘demand’ for health care: The increasing global demand for rehabilitation service for individuals living with chronic obstructive pulmonary disease Michel D Landry, Elham Hamdan, Sabriya Al Mazeedi, Dina Brooks International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:393-396 Published Date: 12 September 2008

REVIEW

Role of arformoterol in the management of COPD Paul King International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:385-391 Published Date: 12 September 2008

REVIEW

Medication adherence issues in patients treated for COPD Ruben D Restrepo, Melissa T Alvarez, Leonard D Wittnebel, Helen Sorenson, Richard Wettstein, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:371-384 Published Date: 12 September 2008

REVIEW

Identifying targets for COPD treatment through gene expression analyses Zhi-Hua Chen, Hong Pyo Kim, Stefan W Ryter, Augustine MK Choi International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:359-370 Published Date: 12 September 2008

OTHER

Noninvasive ventilation in patients with chronic obstructive airway disease Gopi C Khilnani, Amit Banga International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:351-357 Published Date: 12 September 2008

REVIEW

Role of macrolide therapy in chronic obstructive pulmonary disease Fernando J Martinez, Jeffrey L Curtis, Richard Albert International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:331-350 Published Date: 12 September 2008

CASE REPORT

Successful lung transplantation for talcosis secondary to intravenous abuse of oral drug Dekel Shlomi, David Shitrit, Daniele Bendayan, Gidon Sahar, Yitshak Shechtman, Mordechai R Kramer International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:327-330 Published Date: 6 June 2008

CASE REPORT

Assessment of COPD-related outcomes via a national electronic medical record database Carl Asche, Qayyim Said, Vijay Joish, Charles Oaxaca Hall, Diana Brixner International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:323-326 Published Date: 6 June 2008

ORIGINAL RESEARCH

Antibiotics used in the ambulatory management of acute COPD exacerbations Marie-France Beauchesne, Marcel Julien, Louis-André Julien, Dominique Piquette, Amélie Forget, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:319-322 Published Date: 6 June 2008

ORIGINAL RESEARCH

Knowledge and attitudes of family physicians coming to COPD continuing medical education Barbara P Yawn, Peter C Wollan International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:311-317 Published Date: 6 June 2008

ORIGINAL RESEARCH

Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPD A-B Tonnel, T Perez, J-M Grosbois, C Verkindre, M-L Bravo, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:301-310 Published Date: 6 June 2008

ORIGINAL RESEARCH

The influence of the media on COPD patients’ knowledge regarding cardiopulmonary resuscitation Stefano Nava, Carmen Santoro, Mario Grassi, Nicholas Hill International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:295-300 Published Date: 6 June 2008

REVIEW

Smoking and smoking cessation in Latin America: a review of the current situation and available treatments Fernando Müller, Luis Wehbe International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:285-293 Published Date: 6 June 2008

ORIGINAL RESEARCH

COPD and PE: A clinical dilemma Teng Moua, Kenneth Wood International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:277-284 Published Date: 6 June 2008

REVIEW

Diagnostic and therapeutic approach to coexistent chronic obstructive pulmonary disease and obstructive sleep apnea Sanja Jelic International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:269-275 Published Date: 6 June 2008

REVIEW

Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease Caroline A Owen International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:253-268 Published Date: 6 June 2008

REVIEW

Smoking cessation therapy with varenicline Uma M Mohanasundaram, Rajinder Chitkara, Ganesh Krishna International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:239-251 Published Date: 6 June 2008

REVIEW

Long-term oxygen therapy: Are we prescribing appropriately? Mª Rosa Güell Rous International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:231-237 Published Date: 6 June 2008

REVIEW

Airways inflammation and treatment during acute exacerbations of COPD Erik Bathoorn, Huib Kerstjens, Dirkje Postma, Wim Timens, William MacNee International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:217-229 Published Date: 6 June 2008

REVIEW

Formoterol in the management of chronic obstructive pulmonary disease Paschalis Steiropoulos, Argyris Tzouvelekis, Demosthenes Bouros International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:205-215 Published Date: 6 June 2008

REVIEW

Imaging of pulmonary emphysema: A pictorial review Masashi Takahashi, Junya Fukuoka, Norihisa Nitta, Ryutaro Takazakura, Yukihiro Nagatani, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:193-204 Published Date: 6 June 2008

ORIGINAL RESEARCH

Impact of laughter on air trapping in severe chronic obstructive lung disease Martin H Brutsche, Paul Grossman, Rebekka E Müller, Jan Wiegand, Pello, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:185-192 Published Date: 7 March 2008

ORIGINAL RESEARCH

Non-invasive biomarkers and pulmonary function in smokers Zoë L Borrill, Kay Roy, Rupert S Vessey, Ashley A Woodcock, Dave Singh International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:171-183 Published Date: 7 March 2008

ORIGINAL RESEARCH

Cardiovascular morbidity and the use of inhaled bronchodilators Christine Macie, Kate Wooldrage, Jure Manfreda, Nicholas Anthonisen International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:163-169 Published Date: 7 March 2008

ORIGINAL RESEARCH

Outpatient pulmonary rehabilitation in patients with chronic obstructive pulmonary disease Shahin Barakat, Germain Michele, Pastene George, Viallet Nicole, Annat Guy International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:155-162 Published Date: 7 March 2008

ORIGINAL RESEARCH

Systemic inflammation after inspiratory loading in chronic obstructive pulmonary disease Antonia Fuster, Jaume Sauleda, Ernest Sala, Bernardí Barceló, Jaume Pons, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:149-153 Published Date: 7 March 2008

ORIGINAL RESEARCH

Effect of add-on therapy of tiotropium in COPD treated with theophylline Tomotaka Kawayama, Tomoaki Hoshino, Masao Ichiki, Toru Tsuda, Masaharu Kinoshita, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:137-147 Published Date: 7 March 2008

ORIGINAL RESEARCH

Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients Steven Kesten, Richard Casaburi, David Kukafka, Christopher B Cooper International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:127-136 Published Date: 7 March 2008

ORIGINAL RESEARCH

Impairment of small airways in COPD patients with frequent exacerbations and effects of treatment with tiotropium Cristoforo Incorvaia, Gian Galeazzo Riario-Sforza, Chiara Pravettoni, Mona-Rita Yacoub, Franco Frati International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:123-126 Published Date: 7 March 2008

REVIEW

Treatment of COPD: A matrix perspective Sarah E Dunsmore International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:113-122 Published Date: 7 March 2008

REVIEW

Patient education programs – can they improve outcomes in COPD? Melanie Harris, Brian J Smith, Antony Veale International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:109-112 Published Date: 7 March 2008

REVIEW

Investigation of airways using MDCT for visual and quantitative assessment in COPD patients Pierre-Yves Brillet, Catalin I Fetita, Amaury Saragaglia, Anne-Laure Brun, Catherine Beigelman-Aubry, et al International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:97-107 Published Date: 7 March 2008

REVIEW

Mechanisms of atherothrombosis in chronic obstructive pulmonary disease Filippo Luca Fimognari, Simone Scarlata, Maria Elisabetta Conte, Raffaele Antonelli Incalzi International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:89-96 Published Date: 7 March 2008

Pharmacoeconomics in COPD: lessons for the future Helen J Starkie, Andrew H Briggs, Mike G Chambers International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:71-88 Published Date: 7 March 2008

REVIEW

Pulmonary hypertension associated with COPD Jean Elwing, Ralph J Panos International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:55-70 Published Date: 7 March 2008

REVIEW

The use of bupropion SR in cigarette smoking cessation Scott Wilkes International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:45-53 Published Date: 7 March 2008

REVIEW

Optimizing antibiotic selection in treating COPD exacerbations Attiya Siddiqi, Sanjay Sethi International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:31-44 Published Date: 7 March 2008

REVIEW

End of life care in chronic obstructive pulmonary disease: in search of a good death Anna Spathis, Sara Booth International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:11-29 Published Date: 7 March 2008

REVIEW

Optimizing economic outcomes in the management of COPD Roberto Dal Negro International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:1-10 Published Date: 7 March 2008

Editorial: Tiotropium; more knowledge leads to more questions ||FREE PAPER|| Dave Singh International Journal of Chronic Obstructive Pulmonary Disease 2008, 3:0-0 Published Date: 7 March 2008

A new staging strategy for chronic obstructive pulmonary disease Martin R Miller, Ole F Pedersen, Asger Dirksen International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:657-663 Published Date: 15 January 2008

A pilot study of inspiratory capacity and resting dyspnea correlations in exacerbations of COPD and asthma Jeffrey J Pretto, Marcus A McMahon, Peter D Rochford, David J Berlowitz, Susan M Jones, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:651-656 Published Date: 15 January 2008

Detection of Chlamydia pneumoniae on cytospin preparations from bronchoalveolar lavage in COPD patients and in lung tissue from advanced emphysema Eva Brandén, Judy Gnarpe, Gunnar Hillerdal, Lotta Orre, C Magnus Sköld, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:643-650 Published Date: 15 January 2008

Gender differences in the association between C-reactive protein, lung function impairment, and COPD Inga Sif Ólafsdóttir, Thórarinn Gíslason, Bjarni Thjóðleifsson, Ísleifur Ólafsson, Davíd Gíslason, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:635-642 Published Date: 15 January 2008

Small airways ventilation heterogeneity and hyperinflation in COPD: Response to tiotropium bromide Sylvia Verbanck, Daniël Schuermans, Walter Vincken International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:625-634 Published Date: 15 January 2008

Observational studies of a one year self-management program and a two year pulmonary rehabilitation program in patients with COPD Borghild K Lomundal, Aslak Steinsbekk International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:617-624 Published Date: 15 January 2008

Respiratory disturbance during sleep in COPD patients without daytime hypoxemia Ana C Krieger, Nilam Patel, Daniel Green, Frank Modersitzki MPH, Ilana Belitskaya-Levy, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:609-615 Published Date: 15 January 2008

Physicochemical compatibility of fluticasone-17-propionate nebulizer suspension with ipratropium and albuterol nebulizer solutions Wolfgang Kamin, Astrid Schwabe, Irene Krämer International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:599-607 Published Date: 15 January 2008

Upregulation of elastin expression in constrictive bronchiolitis obliterans Adrian Shifren, Jason C Woods, Daniel B Rosenbluth, Susan Officer, Joel D Cooper, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:593-598 Published Date: 15 January 2008

Effect of a noninvasive ventilatory support during exercise of a program in pulmonary rehabilitation in patients with COPD Shahin Barakat, Germain Michele, Pascale Nesme, Viallet Nicole, Annat Guy International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:585-591 Published Date: 15 January 2008

Acute inflammatory and anabolic systemic responses to peak and constant-work-rate exercise bout in hospitalized patients with COPD Martijn A Spruit, Thierry Troosters, Rik Gosselink, Ahmad Kasran, Marc Decramer International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:575-583 Published Date: 15 January 2008

Prevalence of chronic obstructive pulmonary disease and pattern of comorbidities in a general population Caterina Anecchino, Elisa Rossi, Caterina Fanizza, Marisa De Rosa, Gianni Tognoni, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:567-574 Published Date: 15 January 2008

A dose-ranging study of tiotropium delivered via Respimat® Soft Mist™ Inhaler or HandiHaler® in COPD patients Denis Caillaud, Charles Le Merre, Yan Martinat, Bernard Aguilaniu, Demetri Pavia International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:559-565 Published Date: 15 January 2008

Fixed combination therapies in COPD – effect on quality of life Beatrix Groneberg-Kloft, Axel Fischer, Tobias Welte International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:551-557 Published Date: 15 January 2008

Genetics of chronic obstructive pulmonary disease Carola Seifart, Alexandra Plagens International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:541-550 Published Date: 15 January 2008

Beta-blockers use in patients with chronic obstructive pulmonary disease and concomitant cardiovascular conditions Khaled Albouaini, Mohammed Andron, Albert Alahmar, Mohaned Egred International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:535-540 Published Date: 15 January 2008

Treating COPD with PDE 4 inhibitors William M Brown International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:517-533 Published Date: 15 January 2008

Perioperative medical management of patients with COPD Marc Licker, Alexandre Schweizer, Christoph Ellenberger, Jean-Marie Tschopp, John Diaper, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:493-515 Published Date: 15 January 2008

A review of etiologies of depression in COPD Rachel J Norwood International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:485-491 Published Date: 15 January 2008

Pathophysiology of viral-induced exacerbations of COPD Potena Alfredo, Caramori Gaetano, Casolari Paolo, Contoli Marco, Sebastian L Johnston, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:477-483 Published Date: 15 January 2008

Non-invasive ventilation in exacerbations of COPD Nicolino Ambrosino, Guido Vagheggini International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:471-476 Published Date: 15 January 2008

Defect of alveolar regeneration in pulmonary emphysema: Role of lung fibroblasts Laurent Plantier, Jorge Boczkowski, Bruno Crestani International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:463-469 Published Date: 15 January 2008

Role of angiogenesis and vascular remodeling in chronic obstructive pulmonary disease Nikolaos M Siafakas, Katerina M Antoniou, Eleni G Tzortzaki International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:453-462 Published Date: 15 January 2008

Review of ventilatory techniques to optimize mechanical ventilation in acute exacerbation of chronic obstructive pulmonary disease Raghu M Reddy, Kalpalatha K Guntupalli International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:441-452 Published Date: 15 January 2008

Exercise dyspnea in patients with COPD Loredana Stendardi, Barbara Binazzi, Giorgio Scano International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:429-439 Published Date: 15 January 2008

Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease Andrew J Thorley, Teresa D Tetley International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:409-428 Published Date: 15 January 2008

Clinical use of exhaled biomarkers in COPD Philip O’Reilly, William Bailey International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:403-408 Published Date: 15 January 2008

Co-morbid disease in COPD – more than a coincidence / Do chronic obstructive pulmonary disease (COPD) patients that snore have an increased risk of obstructive sleep apnea? ||FREE PAPER|| Alan J Crockett, David Price / Nicholas Hart International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:399-401 Published Date: 15 January 2008

Development and results of the Spanish registry of patients with alpha-1-antitrypsin deficiency Beatriz Lara, Cristian de la Roza, Sara Vilà, Rafael Vidal, Marc Miravitlles International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:393-398 Published Date: 15 October 2007

Volumetric capnography and chronic obstructive pulmonary disease staging Pablo V Romero, Benigno Rodriguez, Daniela de Oliveira, L Blanch, Federico Manresa International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:381-391 Published Date: 15 October 2007

Matrix metalloproteinases -8, -9 and -12 in smokers and patients with Stage 0 COPD Helen Ilumets, Paula Rytilä, Ingel Demedts, Guy G Brusselle, Anssi Sovijärvi, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:369-379 Published Date: 15 October 2007

Effect of change of reference standard to NHANES III on interpretation of spirometric ‘abnormality’ Akshay Sood, Beth K Dawson, Joseph Q Henkle, Patricia Hopkins-Price, Clifford Qualls International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:361-367 Published Date: 15 October 2007

Improvements in exercise capacity during a 4-weeks pulmonary rehabilitation program for COPD patients do not correspond with improvements in self-reported health status or quality of life Einar Haave, Michael E Hyland, Harald Engvik International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:355-359 Published Date: 15 October 2007

Measurement of the acute inflammatory response to walking exercise in COPD: effects of pulmonary rehabilitation Jane Canavan, Rachel Garrod, Johanna Marshall, David Jackson, Paula Ansley, Andy Jewell International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:347-353 Published Date: 15 October 2007

Bacterial lysate in the prevention of acute exacerbation of COPD and in respiratory recurrent infections F Braido, F Tarantini, V Ghiglione, G Melioli, G W Canonica International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:335-345 Published Date: 15 October 2007

Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease Xavier Busquets, Niall G MacFarlane, Damià Heine-Suñer, Montse Morlá, Laura Torres-Juan, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:329-334 Published Date: 15 October 2007

Factors affecting health status in COPD patients with co-morbid anxiety or depression Minna J Hynninen, Ståle Pallesen, Inger Hilde Nordhus International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:323-328 Published Date: 15 October 2007

ORIGINAL RESEARCH

Plasma homocysteine is elevated in COPD patients and is related to COPD severity Terence AR Seemungal, Johanna Cho Fook Lun, Gershwin Davis, Carlos Neblett, Nkhabe Chinyepi, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:313-321 Published Date: 15 October 2007

New insights on COPD imaging via CT and MRI N Sverzellati, F Molinari, T Pirronti, L Bonomo, P Spagnolo, M Zompatori International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:301-312 Published Date: 15 October 2007

Factors contributing to muscle wasting and dysfunction in COPD patients Rob CI Wüst, Hans Degens International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:289-300 Published Date: 15 October 2007

Potential therapeutic applications of hyaluronan in the lung Jerome O Cantor International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:283-288 Published Date: 15 October 2007

Pulmonary hypertension and chronic cor pulmonale in COPD Adil Shujaat, Ruth Minkin, Edward Eden International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:273-282 Published Date: 15 October 2007

Tuberculosis and its incidence, special nature, and relationship with chronic obstructive pulmonary disease Biswajit Chakrabarti, Peter MA Calverley, Peter DO Davies International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:263-272 Published Date: 15 October 2007

Adherence to disease management programs in patients with COPD Johnson George, David CM Kong, Kay Stewart International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:253-262 Published Date: 15 October 2007

Risk factors of hospitalization and readmission of patients with COPD exacerbation – systematic review Katayoon Bahadori, J Mark FitzGerald International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:241-251 Published Date: 15 October 2007

Influenza: the virus and prophylaxis with inactivated influenza vaccine in “at risk” groups, including COPD patients Arnt-Ove Hovden, Rebecca Jane Cox, Lars Reinhardt Haaheim International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:229-240 Published Date: 15 October 2007

Future therapeutic treatment of COPD: Struggle between oxidants and cytokines Willem I de Boer, Hongwei Yao, Irfan Rahman International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:205-228 Published Date: 15 October 2007

Moxifloxacin in the management of exacerbations of chronic bronchitis and COPD Marc Miravitlles International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:191-204 Published Date: 15 October 2007

Editorial: Reference values in lung function testing: All for one and one for all? || FREE PAPER || Brendan G Cooper International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:189-190 Published Date: 15 October 2007

Orbital emphysema in COPD with bronchopleural fistula Daya Upadhyay, Peter HS Sporn International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:187-188 Published Date: 15 July 2007

Tobacco consumption in relation to causes of death in an urban population of north India Ram B Singh, Surendra Singh, Pronobesh Chattopadhya, Kalpana Singh, Vijender Singh, et al International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:177-185 Published Date: 15 July 2007

Cost-effectiveness and healthcare budget impact in Italy of inhaled corticosteroids and brochodilators for severe and very severe COPD patients Roberto Dal Negro, M Eandi, L Pradelli, S Iannazzo International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:169-176 Published Date: 15 July 2007

Outcomes in COPD patients receiving tiotropium or salmeterol plus treatment with inhaled corticosteroids Richard Hodder, Steven Kesten, Shailendra Menjoge, Klaus Viel International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:157-167 Published Date: 15 July 2007

COPD heterogeneity: Gender differences in the multidimensional BODE index Juan P de Torres, Ciro Casanova, Angela Montejo de Garcini, Armando Aguirre Jaime, Bartolomé R Celli International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:151-155 Published Date: 15 July 2007

Chronic airflow limitation in developing countries: burden and priorities Nadia Aït-Khaled, Donald A Enarson, Salah Ottmani, Asma El Sony, Mai Eltigani, Ricardo Sepulveda International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:141-150 Published Date: 15 July 2007

Pulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema Josephine Lenssen, Jan Stolk International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:131-139 Published Date: 15 July 2007

PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast Victoria Boswell-Smith, Domenico Spina International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:121-129 Published Date: 15 July 2007

Genetic predisposition to accelerated decline of lung function in COPD Néstor A Molfino International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:117-119 Published Date: 15 July 2007

Comparison and optimal use of fixed combinations in the management of COPD Mirjam Mensing, René Aalbers International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:107-116 Published Date: 15 July 2007

Role of tiotropium in the treatment of COPD Kathryn L Rice, Ken M Kunisaki, Dennis E Niewoehner International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:95-105 Published Date: 15 July 2007

Editorial: Which bronchodilator in COPD? || FREE PAPER || Richard Russell, Dave Singh International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:93-94 Published Date: 15 July 2007

Stress distribution in a three dimensional, geometric alveolar sac under normal and emphysematous conditions Jessica de Ryk, Jacqueline Thiesse, Eman Namati, Geoffrey McLennan International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:81-91 Published Date: 15 April 2007

Effects of acute hypoxia on left and right ventricular contractility in chronic obstructive pulmonary disease Ferit Akgül, Talantbek Batyraliev, Zarema Karben, Igor Pershukov International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:77-80 Published Date: 15 April 2007

Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients Zoë L Borrill, R Cerys Starkey, S Dave Singh International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:71-76 Published Date: 15 April 2007

Effects of active tobacco smoking on the prevalence of asthma-like symptoms in adolescents Javier Mallol, José A Castro-Rodriguez, Eliana Cortez International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:65-69 Published Date: 15 April 2007

Influenza infection and COPD Patrick Mallia, Sebastian L Johnston International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:55-64 Published Date: 15 April 2007

Prevention and control of influenza in persons with chronic obstructive pulmonary disease Pedro Plans-Rubió International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:41-53 Published Date: 15 April 2007

The development of anticholinergics in the management of COPD Jane E Scullion International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:33-40 Published Date: 15 April 2007

Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis Francesco Blasi, Stefano Aliberti, Paolo Tarsia, PierAchille Santus, Stefano Centanni, Luigi Allegra International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:27-31 Published Date: 15 April 2007

Respiratory muscles training in COPD patients Ernesto Crisafulli, Stefania Costi, Leonardo M Fabbri, Enrico M Clini International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:19-25 Published Date: 15 April 2007

Bronchodilators in COPD: Impact of -agonists and anticholinergics on severe exacerbations and mortality Shelley R Salpeter International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:11-18 Published Date: 15 April 2007

Occasional review: Influenza in COPD: pathogenesis, prevention, and treatment Geertjan Wesseling International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:5-10 Published Date: 15 April 2007

Editorial Selection: Reproducibility of exhaled biomarkers in COPD—the road less traveled & Active smoking among asthmatic youth—How concerned we need to be ||FREE PAPER|| Ildiko Horvath; Aida Semic-Jusufagic, Adnan Custovic International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:2-4 Published Date: 15 April 2007

Editorial: Influenza infection in COPD || FREE PAPER || Dave Singh, Richard Russell International Journal of Chronic Obstructive Pulmonary Disease 2007, 2:1-1 Published Date: 15 April 2007

Risk factors for symptom onset in PI*Z alpha-1 antitrypsin deficiency Annyce S Mayer, James K Stoller, Sverre Vedal, A James Ruttenber, Matt Strand, et al International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:485-492 Published Date: 15 January 2007

Effect of bronchodilatation on single breath pulmonary uptake of carbon monoxide in chronic obstructive pulmonary disease Simonetta Baldi, Claudio Fracchia, Claudio Bruschi, Roberto Dore, Roberto Maestri, et al International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:477-483 Published Date: 15 January 2007

Comparison of oxygenation in peripheral muscle during submaximal aerobic exercise, in persons with COPD and healthy, matched-control persons Krista G Austin, Larry Mengelkoch, Jennifer Hansen, Edward Shahady, Prawee Sirithienthad, Lynn Panton International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:467-475 Published Date: 15 January 2007

Randomized placebo controlled assessment of airway inflammation due to racemic albuterol and levalbuterol via exhaled nitric oxide testing John F Freiler, Rajiv Arora, Thomas C Kelley, Larry Hagan, Patrick F Allan International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:461-466 Published Date: 15 January 2007

Use of accelerometers to characterize physical activity patterns with COPD exacerbations Huong Q Nguyen, Bonnie Steele, Joshua O Benditt International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:455-460 Published Date: 15 January 2007

Creatine supplementation and physical training in patients with COPD: A double blind, placebocontrolled study Gun Faager, Karin Söderlund, Carl Magnus Sköld, Siw Rundgren, Anna Tollbäck, Per Jakobsson International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:445-453 Published Date: 15 January 2007

Diagnosis of airway obstruction in primary care in the UK: the CADRE (COPD and Asthma Diagnostic/management REassessment) programme 1997–2001 Mike Pearson, Jon G Ayres, Maria Sarno, Dan Massey, David Price International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:435-443 Published Date: 15 January 2007

Role of N-acetylcysteine in the management of COPD Anna M Sadowska, J Verbraecken, K Darquennes, WA De Backer International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:425-434 Published Date: 15 January 2007

Pharmacological treatment of chronic obstructive pulmonary disease Paolo Montuschi International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:409-423 Published Date: 15 January 2007

Immediate and early discharge for patients with exacerbations of chronic obstructive pulmonary disease: is there a role in “real life”? Mahendran Chetty, Mel MacKenzie, Graham Douglas, Graeme P Currie International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:401-407 Published Date: 15 January 2007

Hyperinflation and its management in COPD Luis Puente-Maestu, William W Stringer International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:381-400 Published Date: 15 January 2007

Evaluation of PDE4 inhibition for COPD Desuo Wang, Xiangli Cui International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:373-379 Published Date: 15 January 2007

Respiratory disorders during sleep in chronic obstructive pulmonary disease Oreste Marrone, Adriana Salvaggio, Giuseppe Insalaco International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:363-372 Published Date: 15 January 2007

Is there any treatment other than drugs to alleviate dyspnea in COPD patients? Nicolino Ambrosino, Guido Vagheggini International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:355-361 Published Date: 15 January 2007

The role of combination therapy with corticosteroids and long-acting 2-agonists in the prevention of exacerbations in COPD Mario Cazzola, Nicola A Hanania International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:345-354 Published Date: 15 January 2007

Editorial: Diagnosing COPD ||FREE PAPER|| David MG Halpin International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:343-344 Published Date: 15 January 2007

Strategies for improving outcomes of COPD exacerbations Tom Wilkinson, JA Wedzicha International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:335-342 Published Date: 15 September 2006

Biological targets for therapeutic interventions in COPD: clinical potential Girolamo Pelaia, Alessandro Vatrella, Luca Gallelli, Teresa Renda, Mario Caputi, et al International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:321-334 Published Date: 15 September 2006

Depression in COPD — management and quality of life considerations Kurt B Stage, Thomas Middelboe, Tore B Stage, Claus H Sørensen International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:315-320 Published Date: 15 September 2006

Cough and its importance in COPD Jaclyn Smith, Ashley Woodcock International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:305-314 Published Date: 15 September 2006

Palliative management of refractory dyspnea in COPD Hope E Uronis, David C Currow, Amy P Abernethy International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:289-304 Published Date: 15 September 2006

Cost-effectiveness of smoking cessation and the implications for COPD Michele A Faulkner, Tom L Lenz, Julie A Stading International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:279-287 Published Date: 15 September 2006

Genotypes in matrix metalloproteinase 9 are a risk factor for COPD Yohannes Tesfaigzi, Orrin B Myers, Christine A Stidley, Kurt Schwalm, Maria Picchi, et al International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:267-278 Published Date: 15 September 2006

A meta-analysis on the efficacy of oral theophylline in patients with stable COPD Néstor A Molfino, Peter Zhang International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:261-266 Published Date: 15 September 2006

Use of Respimat® Soft Mist™ Inhaler in COPD patients Paula Anderson International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:251-259 Published Date: 15 September 2006

Newer fluoroquinolones in the treatment of acute exacerbations of COPD Amit Patel, Robert Wilson International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:243-250 Published Date: 15 September 2006

Salmeterol/fluticasone combination in the treatment of COPD K F Chung International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:235-242 Published Date: 15 September 2006

Changing the burden of COPD mortality David M Mannino, Victor A Kiri International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:219-233 Published Date: 15 September 2006

The severity of airways obstruction as a determinant of treatment response in COPD Peter MA Calverley, Romain A Pauwels, Paul W Jones, Julie A Anderson, Jørgen Vestbo International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:209-218 Published Date: 15 September 2006

Editorial: The benefits of combined treatment with corticosteroids and long-acting beta agonists ||FREE PAPER|| Dave Singh International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:207-208 Published Date: 15 September 2006

Functional results of unilateral lung volume reduction surgery in alpha1-antitrypsin deficient patients Gaëlle Dauriat, Hervé Mal, Gilles Jebrak, Olivier Brugière, Yves Castier, et al International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:201-206 Published Date: 15 June 2006

Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep D David S Collie, Nicola McLean, Jean-Michel Sallenave, Alison Baker, Richard Blundell, et al International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:189-199 Published Date: 15 June 2006

Physiological associations of computerized tomography lung density: a factor analysis Suzanne Marsh, Sarah Aldington, Mathew V Williams, Michael Nowitz, Andrew Kingzett-Taylor, et al International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:181-187 Published Date: 15 June 2006

Oxidative and nitrosative stress in the diaphragm of patients with COPD Hanneke JH Wijnhoven, Leo MA Heunks, Maartje CP Geraedts, Theo Hafmans, José R Viña, PN Richard Dekhuijzen International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:173-179 Published Date: 15 June 2006

Apoptotic mechanisms in the pathogenesis of COPD Maria Plataki, Eleni Tzortzaki, Paula Rytila, Makris Demosthenes, Anastassios Koutsopoulos, Nikolaos M Siafakas International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:161-171 Published Date: 15 June 2006

Alpha1-antitrypsin deficiency: current perspective on research, diagnosis, and management Jan Stolk, Niels Seersholm, Noor Kalsheker International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:151-160 Published Date: 15 June 2006

Emerging role of MAP kinase pathways as therapeutic targets in COPD Becky A Mercer, Jeanine M D’Armiento International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:137-150 Published Date: 15 June 2006

Current status of noninvasive ventilation in stable COPD patients Salvador Díaz-Lobato, Sagrario Mayoralas Alises, Esteban Pérez Rodrí guez International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:129-135 Published Date: 15 June 2006

Role of mucolytics in the management of COPD Phillippa J Poole International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:123-128 Published Date: 15 June 2006

Budesonide–formoterol (inhalation powder) in the treatment of COPD Erkan Ceylan International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:115-122 Published Date: 15 June 2006

Tiotropium bromide David A Lipson International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:107-114 Published Date: 15 June 2006

The role for N-acetylcysteine in the management of COPD PNR Dekhuijzen, WJC van Beurden International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:99-106 Published Date: 15 June 2006

Editorial: The big picture and the little picture ||FREE PAPER|| Richard Russell International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:97-97 Published Date: 15 June 2006

Does the multidemsional grading system (BODE) correspond to diferences in health status of patients with COPD? Kian-Chung Ong, Swat-Jin Lu, Cindy Seok-Chin Soh International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:91-96 Published Date: 15 March 2006

Mitochondrial function in diaphragm of emphysematous hamsters after treatment with nandrolone Hanneke JH Wijnhoven, Leo Ennen, Richard JT Rodenburg, PN Richard Dekhuijzen International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:83-89 Published Date: 15 March 2006

Lower limb vasodilatory capacity is not reduced in patients with moderate COPD Surendran Sabapathy, Marc F Awater, Donald A Schneider, Rebecca A Kingsley, Maria TE Hopman, Norman R Morris International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:73-81 Published Date: 15 March 2006

Is there a role for mask continuous positive airway pressure in acute respiratory failure due to COPD? Lessons from a retrospective audit of 3 different cohorts Sandra Dial, Dick Menzies International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:65-72 Published Date: 15 March 2006

Depression in the patient with COPD Ian Wilson International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:61-64 Published Date: 15 March 2006

Clinical implications of airway hyperresponsiveness in COPD Nicola Scichilone, Salvatore Battaglia, Alba La Sala, Vincenzo Bellia International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:49-60 Published Date: 15 March 2006

Eosinophilic airway inflammation in COPD Shironjit Saha, Christopher E Brightling International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:39-47 Published Date: 15 March 2006

Akt in the pathogenesis of COPD Steven Bozinovski, Ross Vlahos, Michelle Hansen, Ken Liu, Gary P Anderson International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:31-38 Published Date: 15 March 2006

Antioxidant therapies in COPD Irfan Rahman International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:15-29 Published Date: 15 March 2006

The history of COPD Thomas L Petty International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:3-14 Published Date: 15 March 2006

Editorial: COPD: The end of the beginning ||FREE PAPER|| Richard Russell, Dave Singh, Irfan Rahman, Alan J Crockett International Journal of Chronic Obstructive Pulmonary Disease 2006, 1:1-1 Published Date: 15 March 2006

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