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Comparing the effects of growth hormone and IGF-1 signaling on spatial learning and memory N. M. Ashpole, S. Logan, E. E. Parks, E. L. Hodges, D. B. Owen, J. A. Farley, W. E. Sonntag. USA Reduced IGF-1 signaling alters sirtuins in hippocampus and affects learning and memory S. Logan, N. Ashpole, J. Farley, D. Owens, W. E. Sonntag. USA Sex-common and sexually-dimorphic alterations in hippocampal DNA methylation with aging D. R. Masser, D. R. Stanford, N. Hadad, W. E. Sonntag, A. Richardson, W. M. Freeman. USA Retinal DNA methylation alterations in a rodent model of diabetic retinopathy D. R. Masser, D. R. Stanford, N. Hadad, W. E. Sonntag, A. Richardson, W. M. Freeman. USA Short-term exposure to hypothermia attenuates brain infarction and inflammation in aged rats A. Gresita. R. E. Sandu, A. Zavaleanu, D. Dumbrava, A. Popa. GERMANY, ROMANIA Genes involved in axonal regeneration in old post-stroke rats A.D. Zavaleanu, A.M. Buga, A. Gresita, A. Popa, E. Radu. BUCHAREST, GERMANY, ROMANIA Here, there and everywhere: disconnecting healthspan from lifespan by knocking down MTORC1 in neurons S. A. Hussong, R. Burbank, J. Halloran, A.-L. Lin, V. Y. Soto, V. Galvan. USA Increased OXT in the hypothalamic PVN in male mood disorder patients: a possible direct inhibition of testosterone on OXT expression D. Dai, Q. Li, S.-H. Hu, R. Balesar, D. Swaab, A.-M. Bao. CHINA, NETHERLANDS Sexual dimorphic regulation of stress response: effect of gonadectomy in the rat L. Guo, Y.-X. Chen, Y.-Y. Hu X.–Y. Wu, Y. He, M-L. Huang, D. F. Swaab, A.-M. Bao. CHINA, NETHERLANDS A sensitive and practical RP-HPLC-FLD for determination of the low neuroactive amino acid levels in body fluids and its application in depression J.-L. Wu, S.-Y. Yu, S.-H. Wu, A.-M. Bao. CHINA Menopause and the aging brain: evaluating relationships between circulating ovarian hormone levels and choline acetyltransferase-containing neurons in the basal forebrain S. V. Koebele, S. E. Mennenga, S. Patel, R. Hiroi, L. T. Hewitt, A. M. Quihuis, L. P. Mayer, C. A. Dyer, L. M. Demers, H. A. Bimonte-Nelson. USA Delivery of 17β-estradiol Using Poly(lactic-co-glycolic acid) nanoparticles for cognitive therapy in a model of surgical menopause A. V. Prakapenka, A. M. Quihuis, R. Hiroi, C. G. Carson, S. Patel, E. Chung, D. M. DiPerna, H. A. Bimonte-Nelson, R. W. Sirianni. USA Interactions between circulating microRNA expression and hormonal control of reproductive function in aging rats E. B. Engler-Chiurazzi, J. Clapper, S. E. Lewis R. Lamb, J. W. Simpkins. USA The impact of aging on post-stroke depression A. M. Buga, R. Surugiu, D. Dumbrava, A. Gresita, A. Zavaleanu, V. Tudorica, A. Popa-Wagner. GERMANY, ROMANIA Intranasal insulin transport and effects in an aged mouse model of Alzheimer’s disease E. M. Rhea, S. Nirkhe, W. A. Banks. USA Metabolic stress as a trigger for cellular senescence T. Nacarelli, C. Sell. USA Mitochondrial haplogroup influences motor function in long-term HIV-1 infected individuals A. Azar, K. Devlin, J. Mell, T. Giovannetti, V. Pirrone, M. Nonnemacher, J. Jacobson, B. Wigdhal W. Dampier, E. Lee, D. J. Libon, C. Sell. USA The effect of calorie restriction on adiponectin and miR-146 in skeletal muscle and adipose tissue of Ames dwarf mice D. Wiesenborn, A. Schneider, B. Victoria, L. Spinel, K. Martyniak, I. Cox, M. M. Masternak. BRAZIL, GERMANY, POLAND, USA
19. Deficiency of ATM in neural cells induces markers of senescence through oxidative stress P. Sunderland, L. Carlessi, A. Corti, E. Sikora, M. Piechota. ITALY, POLAND 20. Characterization of ribosomal RNA methylations modulating life- and healthspan of Caenorhabditis elegans M. Schosserer, J. A. Rollins, C. Heissenberger, F. Nagelreiter, S. Snow, A. Rogers, J. Grillari. AUSTRIA, USA 21. Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity E. van der Spoel, S. W. Jansen, A. Akintola, B. E. Ballieux, C. Cobbaert, P. E. Slagboom, G. J. Blauw, R. G. J. Westendorp , F. Roelfsema, D. van Heemst,, H. Pijl. DENMARK, NETHERLANDS 22. An acute systemic immune challenge rapidly decreases tau phosphorylation in hTau mice expressing murine Tau M. Barron, J. Gartlon, L. Dawson, P. Attkinson, M. Pardon. UK 23. NSUN5 methylates ribosomal RNA and modulates ribosome function in human cells C. Heissenberger, N. Dimitrijevic, Y. Gonskikh, A. Linder, R. Grillari-Voglauer, M. Kos, N. Polacek, J. Grillari, M. Schosserer. AUSTRIA, GERMANY, SWITZERLAND 24. Vascular remodeling in the post-stroke aged brain M. Filfan, R. E. Sandu, A. M. Buga, R. Surugiu, D. A. Dumbrava, A. Popa-Wagner, GERMANY, ROMANIA 25. Gaseous hypothermia increases the density of newly formed blood vessels in the ischemic penumbra of aged rats R. Surugiu, R. E. Sandu, A. M. Buga, M. Filfan, D. A. Dumbrava, A. Popa-Wagner. GERMANY, ROMANIA 26. Impact of resveratrol analogues on a 3D in vitro model of human skin F. Nagelreiter, R. Weinmullner, T. Erker, J. Grillari, M. Schosserer. AUSTRIA 27. Simulating selected hormonal pathways during a 24-hour period and the implications for aging research S. A. Garan, G. Efe, K. Cheung, R. White, D. G. Lee, X. Liu, D. W. Song, A. Gouw, G. Brooks. CANADA, USA 28. Metabolic aging by MYC: Distinct lipid accumulation and phospholipid suppression by MYC in lungs and kidneys detected by Desorption Electro Spray Ionization Mass Spectrometry Imaging (DESI-MSI) A. M. Gouw, K. Margulis, R. N. Zare, D. W. Felsher. USA 29. Using Knowledge-fused Differential Dependency Network (KDDN) simulation to exploit the link between cancer, aging, and metabolism A. M. Gouw, A. Preecha, G. Efe, R. Barakat, S. A. Garan, G. A. Brooks. USA 30. Protein quality control in UVB-induced senescence of human dermal fibroblasts M. Cavinato, Rafal Koziel P. Jansen-Durr. AUSTRIA 31. Altered iron homeostasis in mouse models of aging K. Pabis, B. Scheiber-Mojdehkar, T. Valencak, K. Nowikovsky. AUSTRIA 32. Computational study of L-cysteinato-L-asparaginato-copper(II) in gas phase C. Loher, M. Markovic, M. Ramek, I. Mutapcic, J. Sabolovic. AUSTRIA 33. Cognitive impairment in the aging brain: effects of IGF-1 treatment on synaptic transmission A. Orock, S. Logan, N. Szarka, A. Csiszar, W. Sonntag, F. Deak. USA 34. Hypertension-induced impairment in synaptic plasticity and dysregulation of genes involved in synaptic function in the mouse hippocampus: implications for the pathogenesis of vascular cognitive impairment in aging M. N. Valcarcel-Ares, Z. Tucsek, S. Tarantini, P. Hertelendy, C. B. Giles, T. Gautam, A. Orock, W. E. Sonntag, J. D. Wren, A. Csiszar, F. Deak, Z. Ungvari. USA 35. Functional interactions of WRN with PARP1 and ploy(ADP-ribose) M. Mack, S. Veith, A. Schink, M. Hakobyan, A. Bürkle, A. Mangerich
Proceedings to be published in Experimental Gerontology.
THE THIRTEENTH
International Symposium on Neurobiology and Neuroendocrinology of Aging c re a t i ng new networks
Gasthof Hotel Lamm Bregenz Vorarlberg, Austria july 17 – july 22, 2016
Sponsored by: National Institute on Aging Bethesda, Maryland, USA Orentreich Foundation for the Advancement of Science Cold Spring-on-Hudson, New York, USA Land Vorarlberg and Landeshauptstadt Bregenz Bregenz, Austria University of North Dakota School of Medicine and Health Sciences Grand Forks, North Dakota, USA The Junifur and Pasquale Foundation Elsevier
PROGRAM SUNDAY, July 17 1400-1620
George Roth, Pylesville, MD, USA Gerontology: Minicourse and overview 1620-1700 Alexander Bürkle (COBRA Consortium Member), Konstanz, Germany Biomarkers of human aging—the MARK-AGE experience 1700-1745 Bita Nakhai & Alicja Markowska, Bethesda, MD, USA Scientific peer review @NIA (writing tips and addressing review criteria) 1900Opening reception at Gasthof Hotel Lamm Courtesy of Land Vorarlberg and Landeshauptstadt Bregenz MONDAY, July 18 0830 Welcome Holly Brown-Borg, Grand Forks, ND, USA 0845-1215 Session I Chair: Marie Christine Pardon, Nottingham, UK 0845-0930 James Simpkins, Morgantown, WV, USA Role of non-feminizing estrogens in brain protection from cerebral ischemia and Alzheimer’s disease neuropathology 0930-1015 Anna Csiszar, Oklahoma City, OK, USA Cerebrovascular aging: Novel mechanisms and consequences 1015-1045 BREAK 1045-1130 Veronica Galvan, San Antonio, TX, USA TOR drives neuronal and brain vascular dysfunction in mouse models of Alzheimer’s disease 1130-1215 Paula Bickford, Tampa, FL, USA Aging and inflammation in brain plasticity and repair 1900-2030 Session II Chair: Günter Lepperdinger, Salzburg, Austria 1900-1945 Julie Mattison, Poolesville, MD, USA Non-human primates in translational aging research 1945-2030 Georg Wick, Innsbruck, Austria Vaccination against atherosclerosis TUESDAY, July 19 0845-1215 Session III (sponsored by the Orentreich Foundation for the Advancement of Science) Chair: Jay Zimmerman, Queens, NY, USA 0845-0930 Gene Ables, Cold Spring-on-Hudson, NY Pleiotropic effects of methionine restriction 0930-1015 Barbara Shukitt-Hale, Boston, MA USA Improving neuronal and behavioral function in aging with nutrition 1015-1045 BREAK 1045-1130 Nathalie Sumien, Fort Worth, TX Interactions of antioxidant supplementation and moderate exercise on brain function 1130-1215 Kevin Pearson, Lexington, KY, USA Is pregnancy an appropriate time to intervene to improve long-term offspring health? 1400 General Meeting of the Austrian Association for Gerontology –OeAGeron Chair: G. Lepperdinger, Salzburg, Austria 1700-1850 Session IV: Posters Chair: Klaus Richter Session V: 1900-2030 Chair: Holly Brown-Borg, Grand Forks, ND, USA
1900-1945
Peter Adams, Glasgow, UK Epigenetics of cancer and aging: From mechanisms to therapies 1945-2030 Jan Vijg, New York, NY, USA Genome Instability: A conserved mechanism of aging? WEDNESDAY, July 20 0830-1200 Session VI Chair: Aimin Bao, Hangzhou, China 0830-0915 Jack Price, London, UK Are stem cell therapies a realistic option for diseases of the aged brain? 0915-1000 Joanne Conover, Hershey, PA, USA Aging of a neural stem cell niche 1000-1030 BREAK 1030-1115 Aurel Popa-Wagner, Storrs, CT, USA Stem cell therapies in preclinical models of stroke: Is the aged brain microenvironment refractory to cell therapy? 1115-1205 Session VII Short Papers (based on poster abstracts) Chair: Günter Lepperdinger, Salzburg, Austria A. Nicole Ashpole, Oklahoma City, OK USA B. Maria Cavinato, Innsbruck, Austria C. Elizabeth Rhea, Seattle, WA USA D. Matthew Barron, Nottingham, UK E. Stephanie Koebele, Tempe, AZ USA 1900-2000 Session VIII Special Keynote Presentation (sponsored by the Junifur Foundation) Introduction: George Roth, Pylesville, MD, USA George Martin, Seattle, WA USA Geroscience: Funding suggestions for the Billionaire’s Club THURSDAY, July 21 0845-1215 Session IX (sponsored by the COBRA program) Chair: Alexander Bürkle, Konstanz, Germany 0845-0930 Davide De Francesco, London, UK Biomarkers of aging in HIV-positive individuals and matched controls 0930-1015 Rosan van Zoest, Amsterdam, The Netherlands Brain MRI changes associated with poorer cognitive function in treated HIV-1 infection 1015-1045 BREAK 1045-1130 Thijs Booiman, Amsterdam, The Netherlands Contributors to immune senescence during treated HIV-1 infection 1130-1215 Julien Villaudy, Amsterdam, The Netherlands Dissecting aspects of aging in HIV-infected humanized mice on long-term effective antiretroviral therapy 1830-2000 Session X Chair: Marie Christine Pardon, Nottingham, UK 1830-1910 Michal Masternak, Orlando, FL, USA Origin and function of circulating miRNA in long-living Ames dwarf mice 1910-1950 Viviana Perez, Corvallis, OR, USA Uncovering the mechanisms by which rapamycin inhibits cell senescence 1950-2000 Closing – Holly Brown-Borg
INVITED SPEAKERS AND SESSION CHAIRS George Martin University of Washington Seattle, WA USA James Simpkins West Virginia University Morgantown, WV USA Anna Csiszar University of Oklahoma Health Sciences Center Oklahoma City, OK USA Georg Wick Innsbruck Medical University Innsbruck, Austria
Michal Masternak University of Central Florida, Gainesville, FL USA
Davide De Francesco University College London London, UK
Viviana Perez University of Oregon Linus Pauling Institute Corvallis, OR USA
Julien Villaudy AIMM Therapeutics Amsterdam, The Netherlands
Peter Adams Beatson Institute for Cancer Research University of Glasgow, Glasgow UK Jan Vijg Albert Einstein College of Medicine, New York USA
Veronica Galvan University of Texas Health Sciences Center San Antonio, TX USA
Aurel Popa-Wagner Rostock University Medical School Rostock, Germany
Nathalie Sumien University of North Texas Fort Worth, TX USA
Paula Bickford University of South Florida Tampa, FL USA
Julie Mattison National Institutes of Health National Institute on Aging Poolesville, MD USA
Joanne Conover University of Connecticut Storrs, CT USA
Barbara Shukitt-Hale USDA Tufts University Boston, MA USA
Jack Price Wohl Centre for Clinical Neuroscience, Institute of Psychiatry KCL, London, UK
Gene Ables Orentreich Foundation Cold Spring-on-Hudson, NY USA
Rosan van Zoest University of Amsterdam Amsterdam, The Netherlands
Kevin Pearson University of Kentucky Lexington, KY USA
Thijs Booiman University of Amsterdam Amsterdam, The Netherlands
ORGANIZING COMMITTEE Holly Brown-Borg, Grand Forks, ND USA (
[email protected]) Andrzej Bartke - emeritus, Springfield, IL USA Richard Falvo - emeritus, Chapel Hill, NC USA
Michael Ramek - Scientific secretary, Graz University of Technology, Austria (
[email protected])
George Roth Geroscience Inc. Pylesville, MD USA Alexander Bürkle University of Konstanz Konstanz, Germany Bita Nakhai National Institutes of Health National Institute on Aging Bethesda, MD USA Alicja Markowska National Institutes of Health National Institute on Aging Bethesda, MD USA Klaus Richter University of Salzburg Salzburg, Austria
PROGRAM COMMITTEE Aimin Bao, Zhangjiang, China Alexander Bürkle, Konstanz, Germany Günter Lepperdinger, Innsbruck, Austria Roberto C. Melcangi, Milan, Italy Marie-Christine Pardon, Nottingham, UK George Roth, Baltimore, MD USA Jay Zimmerman, Jamaica, NY USA