Jason N. Abrams Angelo State University Department of Chemistry & Biochemistry Cavness Science Building, Room 214A Phone: 325-486-6627; E-mail:
[email protected] Education Bachelor of Science in Chemistry, June 1996, University of Florida, G.P.A. 3.5 (with Honors) Master of Science in Chemistry, May 2002, University of Minnesota; Advisors: Professor George A. O' Doherty/ Professor Craig J. Forsyth Doctor of Philosophy, November 2009, Florida State University Advisor: Professor Igor Alabugin
Academic Teaching and Research Experience 08/2014 to present
Visiting Assistant Professor of Chemistry, Angelo State University • Instruction for organic chemistry lecture/lab course sequence • Undergraduate research involving elaboration of Podophyllotoxin scaffold
08/2013 to 06/2014
Assistant Professor of Chemistry, Bluefield State College • Instruction for general & organic chemistry lecture/lab course sequence • Instruction for 1-semester biochemistry course • Capstone Research Project Mentor
08/2012 to 05/2013
Temporary Chemistry Instructor, South Texas College • Instruction for general & organic chemistry lecture/lab course sequence
08/2009 to 05/2012
Assistant Professor of Chemistry, Xavier University of Louisiana • Instruction for undergraduate organic laboratory courses and organic drill • Summer research with students • Independent research leading to publication in Tetrahedron as full paper
08/2004 to 07/2009
Ph.D. Student, Florida State University; Tallahassee, FL Advisor: Professor Igor V. Alabugin/ Radical 5-Endo Dig Cyclization • Prepared substrates for Radical 5-Endo Dig Cyclization • Derivitized functionally enriched cyclized products
09/1999 to 05/2002
Master’s Student, University of Minnesota; Minneapolis, MN Joint Advisors: Professor George A. O’Doherty/ Professor Craig J. Forsyth Sugar Chemistry: Approaches toward Okadaic Acid and Swainsonine I New methodology toward synthesis of Swainsonine • Constructed novel perhydro-pyrano pyridine compound • Obtained multi-gram quantities of advanced intermediates II Scale-up of middle domain of Okadaic Acid • Utilized large-scale effort: 0.25-1 Kg reactions for initial steps • Accomplished multi-gram scale synthetic routes of middle domain of OA
Graduate Teaching Experience 08/2004 –05/2009
Florida State University, Department of Chemistry Teaching Assistant, undergraduate organic class (I & II) Instructor: Prof. Jack Saltiel/ Prof. Edwin Hilinski • Lead recitation sections in discussions of material for chemistry course
08/2007 –05/2008
Florida State University, Department of Chemistry Teaching Assistant, undergraduate organic laboratory course Instructor: Prof. Mark Kearley • Taught students how to run and purify organic reactions
09/2000 – 06/2002
University of Minnesota, Department of Chemistry Teaching Assistant, advanced undergraduate organic chemistry laboratory Instructor: Prof. George O’Doherty • Taught students multi-step organic reaction methods using a Schlenk line
Industrial Work Experience 06/2002 to 07/2004
Organic Chemist Drug Discovery, Abbott Laboratories Cancer Therapeutic Area • Syntheses of a series of novel indazole-pyridine compounds to establish structure activity relationships (SAR) and pharmacokinetics (PK) as potential AKT Kinase Inhibitors
04/1998 to 08/1999
Process Development Chemist, Roche Carolina • Optimization of routes towards Tamiflu and a COX-II inhibitor • Improved reaction conditions for other large-scale chemical productions
04/1997-04/1998
Process Development Chemist, Nycomed Amersham • Optimized processes for pilot plant reactions including the multi-step route towards metolazone and Hypaque (Diatrizoic acid)
Publications Abrams, J. N.; Zhao, Q.; Ghiviriga, I.; Minaruzzaman “Palladium(II)-catalyzed Enyne Cyclization Strategies toward the Podophyllotoxin Ring System.” Tetrahedron 2012, 68, 423-428. Alabugin, I. V., Timokhin, V. I., Abrams, J. N., Mariappan, M., Abrams, R., Ghiviriga, I. “In Search of Efficient 5-Endo-dig Cyclization of a Carbon-Centered Radical: 40 Years from a Prediction to Another Success for the Baldwin Rules.” J. Am. Chem. Soc. 2008, 130, 10984-10995. Abrams, J. N., Babu, R. S., Guo, Le, D., Le, J., Osbourn, J. M., O'Doherty, G. A. “De Novo Asymmetric Synthesis of 8a-epi-Swainsonine.” J. Org. Chem. 2008, 73, 1943-1940. Li Q., Woods, K. Thomas, S.; Zhu, G.-D., Packard, G., Fisher, J., Li, T., Gong, J., Dinges, J., Song, X., Abrams, J., Yan, L., Johnson, E. F., Shi, Y., Liu, X., Klinghofer, V., Des Jong, R., Oltersdorf, T., Stoll, V. S., Jakob, C. G., Rosenberg, S. H., Giranda, V. L. “Synthesis and Structure-activity Relationship of 3,4'bispyridinylethylenes: Discovery of a Potent 3-isoquinolinylpyridine inhibitor of Protein Kinase B (PKB/Akt) for the Treatment of Cancer.” Bioorg. & Med. Chem. Lett. 2006,16, 2000-2007.
Publications Continued T. M. Hansen, G. J. Florence, P. Lugo-Mas, J. N. Abrams, J. Chen, and C. J. Forsyth “Highly Chemoselective Oxidation of 1,5-Diols to δ-Lactones with TEMPO/BAIB” Tetrahedron Letters. 2003, 44, 57-59.
Patents Li Q., Woods, K. Thomas, S.; Zhu, G.-D., Packard, G., Fisher, J. P., Gong, J., Li, T., Gandhi, V., Thomas, S. A., Packard, G. K., Song, X., Abrams, J. N., Diebold, R., Dinges, J., Hutchins, C., Stoll, V. S., Rosenberg, S. H., Giranda, V. L. “Preparation of Pyridine Derivatives as Protein Kinase Inhibitors.” U.S. Pat. Appl. Publ. 2003, 120 pp. Li Q., Woods, K. Thomas, S.; Zhu, G.-D., Packard, G., Fisher, J. P., Gong, J., Li, T., Gandhi, V., Thomas, S. A., Packard, G. K., Song, X., Abrams, J. N., Diebold, R., Dinges, J., Hutchins, C., Stoll, V. S., Rosenberg, S. H., Giranda, V. L. “Preparation of Heteroaryls for Therapeutic use in Pharmaceutical Compositions as Kinase Inhibitors for Treatment of Hyperproliferative Diseases, Including Cancer.” U. S. Pat. Appl. Publ. 2003, 120 pp. Li Q., Woods, K. Thomas, S.; Zhu, G.-D., Packard, G., Fisher, J. P., Gong, J., Li, T., Gandhi, V., Thomas, S. A., Packard, G. K., Song, X., Abrams, J. N., Diebold, R., Dinges, J., Hutchins, C., Stoll, V. S., Rosenberg, S. H., Giranda, V. L. “Preparation of Pyridine Derivatives as Protein Kinase Inhibitors.” PCT Int. Appl. 2003, 261 pp.
Presentations Jason Abrams, Jasmine Holmes, Corinne Williams, Ion Ghiviriga Synthetic efforts towards podophyllotoxin via a palladium-catalyzed enyne cyclization strategy (December 1st 2010). Poster Presentation 66th SWRM/ 62nd SERMACS New Orleans, LA. David Cook, Jason Abrams, Priscilla Lugo-Mas, and Craig J. Forsyth “Synthesis of Okadaic Acid Analogs” Great Lakes Regional Meeting of the American Chemical Society, Minneapolis, MN, 2002