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Jeffrey Bluestone, PhD
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Professor, School of Medicine
Autoimmune Diseases Diabetes Mellitus, Type 1 Immune Tolerance Autoimmunity T-Lymphocytes, Regulatory
Institution University of California San Francisco Department Diabetes Center Phone 415-514-0417 Email
[email protected]
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Gitelman, Stephen UCSF
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Abbas, Abul
UCSF
Dupage, Michel Tang, Qizhi
Education and Training
UCSF
UCSF
Esensten, Jonathan UCSF
Cornell Graduate School of Medical Science
Ph.D.
1980
Immunology
Rutgers - State University
M.S
1977
Microbiology
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Cook College, Rutgers University
B.S.
1974
Biology
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La Cava, Antonio UCLA
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Abbas, Abul 1989
UCSF
Von Herrath, Matthias
Gould Foundation
1987 -
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American Cancer Society
1989
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1997
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Fogarty Foundation
1997
Senior Research Fellowship
Cornell Medical School
1998
Distinguished Alumni Award
Tang, Qizhi
UCSF
Weiss, Arthur UCSF >> See all (56) people
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Overview Jeffrey Bluestone, PhD, is the A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology and is the Director of the Hormone Research Institute in the Diabetes Center. His research over the past 25 years has focused on understanding the basic processes that control T cell activation and immune tolerance in autoimmunity and organ transplantation. He and members of his lab have developed soluble receptor antagonists; monoclonal antibodies and animals deficient in individual members of TCR and co-stimulatory pathways to define their individual roles in transplant rejection and autoimmunity including a special emphasis on a specialized subset of T cells termed “regulatory T cells” (Treg). Tregs control fundamental aspect of immune homeostasis. During the last several years, his research has adapted the animal studies using biologics and cell based therapies to develop therapeutics that can be used in humans with autoimmunity and under conditions of allotransplant rejection. Moreover, a strong role for antigen-specific Tregs have been found in these model systems and further evidence in humanized Show more + mice and transplant patients that alloantigen-specific Tregs are more effective. Thus, the major goal of this work is to identify the antigen-specificity of thymic- and peripherally-derived Tregs with the expectation that these TCRs can be adapted for immunotherapy. Finally, his lab initiated several projects to determine mechanisms that control Treg Research Activities and Funding
stability. The goal is to develop approaches using pharmacogenomics to either stabilize or destabilize Tregs in Designer Tregs for restoring tolerance in patients with type 1 diabetes autoimmunity and cancer. NIH/NIDDK UC4DK116264 Sep 20, 2017 - Aug 31, 2021 Role: Principal Investigator In March 2010 Dr. Bluestone was appointed executive vice chancellor and provost at the University of California San Francisco (UCSF) serving as chief academic officer guiding the research and academic enterprise advancing the Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance campus priorities in close collaboration with the chancellor and the campus leadership teams, and to oversee the NIH/NIDDK R01DK107383 Jul 1, 2016 - Jun 30, 2020 campus ethics and compliance enterprise. Previously he served in a number of posts including Director of theUCSF Role: Co-Principal Investigator Diabetes Center, as Director of the Immune Tolerance Network. Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance NIH/NIDDK U01DK107383 Jul 1, 2016 - Jun 30, 2020 In June 2008 Dr. Bluestone served as interim vice chancellor of research; directing the advancement of cross-campus Role: Co-Principal Investigator research initiatives, such as enhancing core research facilities. In this capacity, he played a leading role in coordinating and integrating current research cores. He worked also to strengthen external research partnerships, Disruption of T cell tolerance in type 1 diabetes particularly with industry, and focused on facilitating the translation of UCSF discoveries into public benefit. NIH/NIAID P01AI118688 Jun 8, 2016 - May 31, 2021
Role: Co-Investigator In 2009, Dr. Bluestone led the UCSF committee to strategize and secure funds available through the American Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation Recovery and Reinvestment Act, making the campus one of the top institutional recipients in the nation of scienceNIH/NIAID U01AI110658 Jun 1, 2014 - May 31, 2019 based stimulus funds. Featured Publications Role: Co-Principal Investigator Dr. Bluestone joined the UCSF faculty in 2000. He is an international leader in the field of immunotherapy, with a stellar Autoimmunity Center of Excellence Clinical Research Program record of scholarly achievement and a decade of significant contributions to the research enterprise at UCSF, including NIH/NIAID UM1AI110498 May 1, 2014 - Apr 30, 2019 the creation and directorship of an integrated UCSF Diabetes Center to focus on translating basic research in both type Role: Co-Investigator Global Health 1 and type 2 diabetes into improved therapies for patients. He also founded and directed the Immune Tolerance Role of Innate Lymphoid Cells in Autoimmunity Network, a consortium of more than 1,000 of the world’s leading scientific researchers and clinical specialists from NIH/NIAID R21AI107328 Dec 1, 2013 - Nov 30, 2015 nearly 50 institutions, with the mission of testing new therapies to promote immune tolerance in transplantation, Role: Principal Investigator autoimmune diseases, asthma and allergic diseases. "Donor-Specific Regulatory T Cell Therapy in Liver Transplantation" As a research scientist, Dr. Bluestone has helped clarify the body’s immune response on a molecular level. His NIH/NIAID R34AI095135 Apr 1, 2012 - Mar 31, 2014 systematic investigation has catalyzed recent progress in stem cell research, islet cell transplantation and immune Role: Co-Principal Investigator tolerance therapies – experimentation that has formidably translated into drugs to treat human disease. "Expanding beta-cell mass" NIH/NIDDK U01DK089541 Sep 15, 2010 - Jun 30, 2015 Through his 30-year scientific career, he has authored more than 300 peer-reviewed publications that include prominent Role: Co-Principal Investigator papers in Nature, Nature Immunology, and the Journal of Immunology and Diabetes. He has received numerous accolades for his work, including his 2006 election to the American Academy of Arts and Sciences, the Mary Tyler Role of Notch 1 in Immune Tolerance Moore & Robert Levine Excellence in Clinical Research Award from the Juvenile Diabetes Research Foundation, and NIH/NIAID R21AI059979 Apr 1, 2004 - Mar 31, 2007 Websites the distinguished alumni award from the Cornell Graduate School of Medical Science. Role: Principal Investigator
Autoimmunity Center of Excellence Prior to joining UCSF, Bluestone was at the University of Chicago, where he was a member of the Ben May Institute NIH/NIAID U19AI056388 Sep 30, 2003 - Apr 30, 2014 for Cancer Research, rising over 13 years from an associate professor to the director of the institute. He had previously Role: Co-Investigator worked for seven years in various roles at the National Cancer Institute of the National Institutes of Health, ultimately becoming a senior investigator in the Immunology Branch of the National Cancer Institute. Diabetes Research Center NIH/NIDDK P30DK063720 Sep 1, 2002 - Mar 31, 2020 Dr. Bluestone earned both his BS in biology and his MS in microbiology from Rutgers State University, and his PhD in Role: Co-Principal Investigator immunology from the Cornell Graduate School of Medical Science (Sloan-Kettering Division).
In The News Conf on Mechanism and Applications of Immune Tolerance NIH/NIAID R13AI051294
Apr 1, 2002 - Mar 31, 2003
Role: Principal Investigator Spontaneous Autoimmune Model of Peripheral Neuropathy NIH/NIAID R01AI050834
Dec 15, 2001 - Nov 30, 2012
Role: Principal Investigator
Featured Videos Immune Tolerance Network: Autoimmune Diseases NIH/NIAID N01AI15416
Sep 30, 2001 - Apr 30, 2014
Role: Co-Principal Investigator Immune tolerance network: lung transplantation NIH/NIAID N01AI15416-20-0-10
Sep 30, 2001 - Apr 30, 2014
Role: Principal Investigator Immune tolerance network: liver transplantation NIH/NIAID N01AI15416-20-0-11
Sep 30, 2001 - Apr 30, 2014
Role: Principal Investigator Immune Tolerance Network: Systemic lupus rythematosus (SLE) NIH/NIAID N01AI15416-20-0-12
Sep 30, 2001 - Apr 30, 2014
Role: Principal Investigator Immune Tolerance Network: Kidney, Liver and Bone Marrow Transplantation NIH/NIAID N01AI15416-20-0-2
Sep 30, 2001 - Apr 30, 2014
Role: Principal Investigator Immune Tolerance Network: Food Allergy NIH/NIAID N01AI15416-20-0-3
Sep 30, 2001 - Apr 30, 2014
Role: Principal Investigator
Publications
Immune Tolerance Network: Type 1 diabetes Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might NIH/NIAID N01AI15416-20-0-4 Sep 30, 2001 - Apr 30, 2014 result in incorrect or missing publications. Researchers can login to make corrections and additions, or Role: Principal Investigator contact us for help. Immune tolerance network: Multiple sclerosis List All | Timeline NIH/NIAID N01AI15416-20-0-5 Sep 30, 2001 - Apr 30, 2014 1. Hua J, Inomata T, Chen Y, Foulsham W, Stevenson W, Shiang T, Bluestone J, Dana R. Pathological Role: Principal Investigator conversion of regulatory T cells is associated with loss of allotolerance. Sci Rep. 2018 May 04; 8(1):7059. Immune tolerance network: Rheumatoid arthritis PMID: 29728574. NIH/NIAID N01AI15416-20-0-6 Sep 30, 2001 - Apr 30, 2014 View in: PubMed Role: Principal Investigator 2. Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju CH, Sterling T, Nakayama M, Robinson WH, Bluestone J, Immune tolerance network: Autoimmune diseases: Vasculitis Anderson MS, Tang Q. Revealing the specificity of regulatory T cells in murine autoimmune diabetes. Proc Natl NIH/NIAID N01AI15416-20-0-7 Acad Sci U S A. 2018 May 15; 115(20):5265-5270. PMID: 29712852. Role: Principal Investigator View in: PubMed
Sep 30, 2001 - Apr 30, 2014
Immune tolerance network: Islet cell transplantation 3. Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, NIH/NIAID N01AI15416-20-0-8 Sep 30, 2001 - Apr 30, 2014 Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone J, Garcia KC. Selective targeting of Role: Principal Investigator engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science. 2018 03 02; 359(6379):10371042. PMID: 29496879. Immune tolerance network: heart tranplantation View in: PubMed NIH/NIAID N01AI15416-20-0-9
Sep 30, 2001 - Apr 30, 2014
Role: Principal Investigator 4. Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone J, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Immune tolerance network: liver transplantation Giannoukakis N, Golab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, NIH N01AI15416-23-0-11 Sep 30, 2001 - Apr 30, 2014 Iwaszkiewicz-Grzes D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer Role: Principal Investigator K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Immune Tolerance Network: Systemic lupus rythematosus (SLE) Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, NIH Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, N01AI15416-23-0-12 Sep 30, 2001 - Apr 30, 2014 Role: Principal Investigator Lord P, Martinez-Caceres EM, Trzonkowski P. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. 2017; 8:1844. PMID: 29379498. Immune tolerance network: kidney transplantation View in: PubMed NIH N01AI15416-23-0-13 Sep 30, 2001 - Apr 30, 2014 5. Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Role: Principal Investigator Bluestone J, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, DePinho RA, Diasio RB, Draetta G, IImmune Tolerance Network: Airborne Allergens and Allergic Rhintitis Frazier AL, Futreal A, Gambhir SS, Ganz PA, Garraway L, Gerson S, Gupta S, Heath J, Hoffman RI, Hudis C, NIH N01AI15416-23-0-14 Sep 30, 2001 - Apr 30, 2014 Hughes-Halbert C, Ibrahim R, Jadvar H, Kavanagh B, Kittles R, Le QT, Lippman SM, Mankoff D, Mardis ER, Role: Principal Investigator Mayer DK, McMasters K, Meropol NJ, Mitchell B, Naredi P, Ornish D, Pawlik TM, Peppercorn J, Pomper MG, Raghavan D, Ritchie C, Schwarz SW, Sullivan R, Wahl R, Wolchok JD, Wong SL, Yung A. Future cancer Immune Tolerance Network: Food Allergy NIH research priorities in the USA: a Lancet Oncology Commission. Lancet Oncol. 2017 Nov; 18(11):e653-e706. N01AI15416-23-0-3 Sep 30, 2001 - Apr 30, 2014 PMID: 29208398. Role: Principal Investigator View in: PubMed Immune Tolerance Network: Type 1 diabetes 6. Yeh WI, Seay HR, Newby B, Posgai AL, Moniz FB, Michels A, Mathews CE, Bluestone J, Brusko TM. Avidity NIH N01AI15416-23-0-4 Sep 30, 2001 - Apr 30, 2014 and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Role: Principal Investigator Receptors in Type 1 Diabetes. Front Immunol. 2017; 8:1313. PMID: 29123516. Immune tolerance network: Multiple sclerosis View in: PubMed NIH N01AI15416-23-0-5 Sep 30, 2001 - Apr 30, 2014 7. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Role: Principal Investigator Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, FASEB SUMMER CONFERENCE--LYMPHOCYTES AND ANTIBODIES Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK,
NIH/NIAID R13AI047114 Jun 1, 2000 - May 31, 2001 Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone J, Chang HY, Corn JE, Marson A. Discovery of Role: Principal Investigator stimulation-responsive immune enhancers with CRISPR activation. Nature. 2017 09 07; 549(7670):111-115. PMID: 28854172. Immunomodulation of transplant rejection by Anti-CD3 mAb View in: PubMed NIH/NIAID R01AI046643
Mar 1, 2000 - May 31, 2016
Role: Principal Investigator 8. June CH, Warshauer JT, Bluestone J. Corrigendum: Is autoimmunity the Achilles' heel of cancer immunotherapy? Nat Med. 2017 Aug 04; 23(8):1004. PMID: 28777789. IMMUNOMODULATION OF TRANSPLANT REJECTION BY ANTI-CD3 MAB View in: PubMed NIH/NIAID R37AI046643
Mar 1, 2000 - Feb 28, 2011
Role: Principal Investigator 9. June CH, Warshauer JT, Bluestone J. Is autoimmunity the Achilles' heel of cancer immunotherapy? Nat Med. 2017 05 05; 23(5):540-547. PMID: 28475571. MOFLO MULTILASER FLOW CYTOMETER View in: PubMed NIH/NCRR S10RR014884 Mar 1, 2000 - Feb 28, 2001 10. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Role: Principal Investigator Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone J, Papa FR. Targeting ABL-IRE1a COLLABORATIVE NETWORK FOR CLINICAL RES ON IMMUNE TOLERAN Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 05 02; NIH/NIAID N01AI095380 Sep 30, 1999 - Sep 29, 2006 25(5):1207. PMID: 28467938. Role: Principal Investigator View in: PubMed TOLERANCE OF ISLET CELL GRAFT 11. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, NIH/NIDDK R01DK055351 Jun 15, 1999 - May 31, 2003 Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone J, Papa FR. Targeting ABL-IRE1a Role: Principal Investigator Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 04; 25(4):883-897.e8. PMID: 28380378. CTLA 4 ANTAGONISM DURING T CELL ACTIVATION View in: PubMed NIH/NIAID F33AI009895
Mar 22, 1998
Role: Principal Investigator 12. Bluestone J. FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance. J Immunol. 2017 02 01; 198(3):979-980. PMID: 28115585. SCOR in Cellular and Molecular Mechanisms of Asthma View in: PubMed NIH/NHLBI P50HL056399
Sep 30, 1996 - Aug 31, 2006
Role: Co-Principal Investigator 13. Seay HR, Putnam AL, Cserny J, Posgai AL, Rosenau EH, Wingard JR, Girard KF, Kraus M, Lares AP, Brown HL, Brown KS, Balavage KT, Peters LD, Bushdorf AN, Atkinson MA, Bluestone J, Haller MJ, Brusko TM. IMMUNOREGULATION OF IDDM Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive NIH P01DK049799 Jun 15, 1995 - May 31, 2000 Cell Transfer Therapy. Mol Ther Methods Clin Dev. 2017 Mar 17; 4:178-191. PMID: 28345003. Role: Co-Investigator View in: PubMed Immune Tolerance and Autoimmunity 14. Esensten JH, Bluestone J, Lim WA. Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials. NIH/NIAID P01AI035297 Sep 30, 1993 - Jul 31, 2012 Annu Rev Pathol. 2017 Jan 24; 12:305-330. PMID: 27959633. Role: Co-Investigator View in: PubMed COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY 15. Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone J. CD28 Costimulation: From Mechanism to Therapy. NIH/NIAID P01AI035294 Sep 1, 1993 - Aug 31, 2001 Immunity. 2016 05 17; 44(5):973-88. PMID: 27192564; PMCID: PMC4932896 [Available on 05/17/17]. Role: Principal Investigator View in: PubMed, PubMed Central IMMUNOMODULATION OF TRANSPLANT REJECTION 16. Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone J, Buckner JH, Ziegler SF. Correction: CD4+ Group 1 NIH/NIAID P01AI029531 Jun 1, 1990 - Aug 31, 2000 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Role: Principal Investigator Immunol. 2016 May 01; 196(9):3966. PMID: 27183651. View in: PubMed IMMUNOBIOLOGY OF TCR GAMMA/DELTA T-CELLS NIH/NIAID R01AI026847 Sep 1, 1988 - Aug 31, 1999 17. Gitelman SE, Bluestone J. Regulatory T cell therapy for type 1 diabetes: May the force be with you. J Role: Principal Investigator Autoimmun. 2016 07; 71:78-87. PMID: 27133597. View in: PubMed IN VIVO POTENTIATION OF IMMUNE RESPONSES NIH/NCI R01CA049260 Aug 5, 1988 - Jul 31, 1995 18. Gitelman SE, Gottlieb PA, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Role: Principal Investigator Keyes-Elstein L, Harris KM, Kanaparthi S, Phippard D, Ding L, Bluestone J, Ehlers MR. Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial. Diabetologia. 2016 Interdisciplinary Training Program in Immunology 06; 59(6):1153-61. PMID: 27053235; PMCID: PMC4869699. NIH/NIAID T32AI007090 Jul 1, 1979 - Jun 30, 2019 View in: PubMed, PubMed Central Role: Co-Principal Investigator 19. DuPage M, Bluestone J. Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease. Nat Cancer Center Support Grant Rev Immunol. 2016 Mar; 16(3):149-63. PMID: 26875830. NIH P30CA014599 Feb 1, 1977 - Mar 31, 2018 View in: PubMed Role: Co-Investigator 20. Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone J, Buckner JH, Ziegler SF. CD4+ Group 1 Innate IMMUNITY AND CANCER Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J NIH P01CA019266 Jun 1, 1976 - Mar 31, 1996 Immunol. 2016 Mar 01; 196(5):2051-2062. PMID: 26826243; PMCID: PMC4761490 [Available on 03/01/17]. Role: Co-Investigator View in: PubMed, PubMed Central 21. Perdigoto AL, Chatenoud L, Bluestone J, Herold KC. Inducing and Administering Tregs to Treat Human Disease. Front Immunol. 2015; 6:654. PMID: 26834735; PMCID: PMC4722090. View in: PubMed, PubMed Central 22. Bluestone J, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 2015 Nov 25; 7(315):315ra189. PMID: 26606968. View in: PubMed 23. Kishnani PS, Dickson PI, Muldowney L, Lee JJ, Rosenberg A, Abichandani R, Bluestone J, Burton BK, Dewey M, Freitas A, Gavin D, Griebel D, Hogan M, Holland S, Tanpaiboon P, Turka LA, Utz JJ, Wang YM, Whitley CB, Kazi ZB, Pariser AR. Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction. Mol Genet Metab. 2016 Feb; 117(2):66-83. PMID: 26597321. View in: PubMed 24. Holohan DR, Lee JC, Bluestone J. Shifting the Evolving CAR T Cell Platform into Higher Gear. Cancer Cell. 2015 Oct 12; 28(4):401-402. PMID: 26461084. View in: PubMed 25. Spence A, Klementowicz JE, Bluestone J, Tang Q. Targeting Treg signaling for the treatment of autoimmune diseases. Curr Opin Immunol. 2015 Dec; 37:11-20. PMID: 26432763. View in: PubMed 26. Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone J, Doudna JA, Marson A. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10437-42. PMID: 26216948; PMCID: PMC4547290. View in: PubMed, PubMed Central 27. Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone J, Locksley RM. Interleukin-33 and Interferon-? Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015 Jul 21; 43(1):161-74. PMID: 26092469; PMCID: PMC4512852. View in: PubMed, PubMed Central 28. Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, Atkinson MA, Bluestone J, Brusko TM. Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226. J Immunol. 2015 Jul 01; 195(1):145-55. PMID: 25994968; PMCID: PMC4475416. View in: PubMed, PubMed Central 29. Bluestone J, Crellin N, Trotta E. IL-2: Change Structure … Change Function. Immunity. 2015 May 19; 42(5):779-81. PMID: 25992850. View in: PubMed 30. Bluestone J, Bour-Jordan H, Cheng M, Anderson M. T cells in the control of organ-specific autoimmunity. J Clin Invest. 2015 Jun; 125(6):2250-60. PMID: 25985270; PMCID: PMC4497750. View in: PubMed, PubMed Central 31. Bluestone J, Trotta E, Xu D. The therapeutic potential of regulatory T cells for the treatment of autoimmune disease. Expert Opin Ther Targets. 2015; 19(8):1091-103. PMID: 25881491. View in: PubMed 32. Bluestone J, Tang Q. Immunotherapy: making the case for precision medicine. Sci Transl Med. 2015 Mar 25; 7(280):280ed3. PMID: 25810308. View in: PubMed 33. Villalta SA, Rosenberg AS, Bluestone J. The immune system in Duchenne muscular dystrophy: Friend or foe. Rare Dis. 2015; 3(1):e1010966. PMID: 26481612; PMCID: PMC4588155. View in: PubMed, PubMed Central 34. DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone J. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 2015 Feb 17; 42(2):227-238. PMID: 25680271; PMCID: PMC4347854. View in: PubMed, PubMed Central 35. Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone J, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol. 2015 Feb; 16(2):188-96. PMID: 25559257; PMCID: PMC4297515. View in: PubMed, PubMed Central 36. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone J, Derynck R. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. PMID: 25526531; PMCID: PMC4273650 [Available on 12/18/15]. View in: PubMed, PubMed Central 37. Szot GL, Yadav M, Lang J, Kroon E, Kerr J, Kadoya K, Brandon EP, Baetge EE, Bour-Jordan H, Bluestone J. Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm. Cell Stem Cell. 2015 Feb 05; 16(2):148-57. PMID: 25533131. View in: PubMed 38. Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone J. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Dec 04; 124(24):3572-6. PMID: 25323825; PMCID: PMC4256909. View in: PubMed, PubMed Central 39. Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, Margeta M, Spencer MJ, Bluestone J. Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med. 2014 Oct 15; 6(258):258ra142. PMID: 25320234; PMCID: PMC4889432. View in: PubMed, PubMed Central 40. Folias AE, Penaranda C, Su AL, Bluestone J, Hebrok M. Aberrant innate immune activation following tissue injury impairs pancreatic regeneration. PLoS One. 2014; 9(7):e102125. PMID: 25010227; PMCID: PMC4092101. View in: PubMed, PubMed Central 41. Stumpf M, Zhou X, Chikuma S, Bluestone J. Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function. Eur J Immunol. 2014 Jun; 44(6):1737-46. PMID: 24648182; PMCID: PMC4051436. View in: PubMed, PubMed Central 42. Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med. 2014 Jan; 20(1):62-8. PMID: 24362934. View in: PubMed 43. Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, Fehling HJ, Bluestone J. Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity. 2013 Nov 14; 39(5):949-62. PMID: 24238343; PMCID: PMC3912996. 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