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Endothelin action on pituitary latotrophs (Bertram et al. 2006) Help downloading and running models Model Information Model File Citations
Accession:91899 Endothelin (ET-1, -2, and -3 designate three genes which produce different endothelin isopeptides) is a prolactin inhibiting substance of hypothalmic origin. ET-1 binding is part of at least four G protein signaling pathways in lactotrophs. The sequence of events in these pathways following the presentation of nano- and picomolar concentrations of ET-1 is modeled in the paper. Reference: 1 . Bertram R, Tabak J, Toporikova N, Freeman ME (2006) Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins. Sci STKE 2006:pe4 [PubMed]
Model Information (Click on a link to find other models with that property) Model Type: Neuron or other electrically excitable cell; Brain Region(s)/Organism: Cell Type(s): Pituitary cell; Channel(s): I K; I_SERCA; Gap Junctions: Receptor(s): Gene(s): Transmitter(s): Amino Acids; Simulation Environment: XPP (web link to model); Model Concept(s): Activity Patterns; Signaling pathways; Implementer(s): Search NeuronDB for information about: I K; I_SERCA; Amino Acids; (located via links below)
Note from ModelDB Administrator: the below is a copy of the web page http://www.math.fsu.edu/~bertram/software/pituitary/STKE_06/ made on May 8th, 2007. Software for "Endothelin Action on Pituitary Lactotrophs: One receptor, Many GTP-Binding Proteins", Science STKE, 2006(319):pe4, 2006, by R. Bertram, J. Tabak, N. Toporikova, and M. E. Freeman First figure, simulation of nanomolar concentrations of endothelin-1. Figure 1 Second figure, simulation of picomolar concentrations of endothelin-1. Figure 2
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