molecular and functional characterization of irem-3, a new activating [PDF]

Lymphoma) or Dok (Downstream Of Kinase), provide complementary ways for interfering with .... an adaptor protein by virt
0 downloads 5 Views 3MB Size
Report
Download PDF
PNG Network

Recommend Stories

synthesis and characterization of a new class of functional materials
Never wish them pain. That's not who you are. If they caused you pain, they must have pain inside. Wish
Morphological and molecular characterization of a new species of leech
Don't count the days, make the days count. Muhammad Ali
Molecular and functional characterization of erythropoietin receptor of the goldfish
Don't count the days, make the days count. Muhammad Ali
of Cynomolgus Monkey IgG Subclasses Molecular and Functional Characterization
When you do things from your soul, you feel a river moving in you, a joy. Rumi
Morphological and molecular characterization of a new genus and new species of parazoanthid
I tried to make sense of the Four Books, until love arrived, and it all became a single syllable. Yunus
Functional characterization of C6orf97
Make yourself a priority once in a while. It's not selfish. It's necessary. Anonymous
Biochemical, Molecular, and Functional Characterization of PISCF-Allatostatin, a Regulator of
You miss 100% of the shots you don’t take. Wayne Gretzky
Functional characterization of a microbial aquaglyceroporin
Your task is not to seek for love, but merely to seek and find all the barriers within yourself that
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
If you are irritated by every rub, how will your mirror be polished? Rumi
Functional Characterization of a Prokaryotic Kir Channel
Don't ruin a good today by thinking about a bad yesterday. Let it go. Anonymous

Idea Transcript

!

#$%&'($)

"

*+

,

%-.$'./%0' 1% #20&#%3 4-%$#/%0'.53 # 1% 5. .56' 0#7%$3#'.' (/-%6 .8$.

!96%1.

( 8% -$%3%0'%1 #'= #0=#8#'($@ %7%$

/%1#.'%1 #0=#8#'#(0 #3 (05@ 5(&.5 .01 '$.03#%0'* ' 1(%3 0(' #016&% . &%55

>#1% ($ 363'.#0%1 0(0 $%3-(03#7%0%33 86' .8$(9.'%3 .&'#7.'#09 3#90.53 >=%0 .01 >=%$% '=%@ (&&6$ B SC*

S

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

=% 0%9.'#7% $%965.'#(0 (< '=% #//60% 03'$%./

3? B& $& @$(3#0% ?#0.3%C

85 B .3#'.3

5#0%.9%

< O#0.3%C -$(7#1% &(/-5%/%0'.$@ >.@3 =%0 $%5%.3%1 '( '=% &@'(-5.3/ B '@$(3#0%3 (< >#'= '=%

3

C* 0 &(0'$.3' '=% 5(09%$ 3-. 8%'>%%0 '=%

'%$/#0.5

#3 &(/-.'#85% >#'= #0'$./(5%&65.$ %09.9%/%0' (< 8('= '@$(3#0%3 $%3#16%3

'%$/#0.5 '.01%/

1(/.#03 B

C* =%$%03'$%./

γ B =(3-=(5#-.3%

γC

$8

B $(>'= .@3 B VC B #9*

S =.3 .53( 8%%0 3=(>0 '( .33(&#.'% >#'= -.4#55#0 7#/%0'#0 .01 .&'#0 #0 .&'#7.'%1

/.&$(-=.9%3 '=63 #07(57#09 '=%3% -=(3-=.'.3%3 #0 $%965.'#09 '=% .1=%3#(0 -$(-%$'#%3 (< /@%5(#1 &%553 B TC* C

T W V

S

SS

S

VV

TST

W

S

SS

SW

VU

T S

TWV

S

T T

T U

TVW

TXV

C

#96$% S)

S

8%.$#09 -=(3-=.'.3%3* B C

(/.#0 ($9.0#;.'#(0 (<

S .01

-=(3-=.'.3%3*

3=(>0 #0 &(5($%1 8(4%3 .01 ./#0( . -(3#'#(03 .$% 0('%1* %965.'($@ '@$(3#0%3 (0 '=% ) $&

(/(5(9@

1(/.#0* B C

(1%5 (< (-%$.'#(0 =#&=

'%$/#0.5 $%9#(0 .$% 3=(>0*

$& ( '@-%3 (< '$.03/%/8$.0% .1.-'($ -$('%#03 =.7% 8%%0 1%3&$#8%1) '=% 8%.$#09 .1.-'($ -$('%#03 .01 '=%

O .33(&#.'%1 .1.-'($

S ? .C BW X C* =% =%$% 4

/('#< &.-.85%

O .01 '=% #0'$.&%5565.$ .1.-'($ /(5%&65%

$8 * -(0 .99$%9.'#(0 (< &%55 36$.@3 '$#99%$%1 8@ .&'#7.'#09 #//60% $%&%-'($3* &=%/.'#& $%-$%3%0'.'#(0 (< '=% 3#90.5 '$.0316&'#(0 -.'=>.@3 #0#'#.'%1 6-(0 %09.9%/%0' (< (5#9(/%$#& .&'#7.'#09 $%&%-'($3 &(6-5%1 '( & γ .01

ζC .01

8%.$#09 -(5@-%-'#1%3 B

S

S *

&'#7.'#09 #//60% $%&%-'($3 8%5(09 '( '>( %7(56'#(0.$@ 1#3'#0&' -$('%#0 36-%$=#&= 1#=#&= #07.$#.85@ &($$%3-(013 '( .0 .3-.$'#& .* 6$#(635@

S .1.-'($ /(5%&65% =.3 . 3'$(09 -$%#'=

S =.7% . '$.03/%/8$.0% 5@3#0%*

(07%$3%5@

& γ =.3 . -$%#'=#0 #'3 '$.03/%/8$.0% 1(/.#0* =% &=.$9%1 $%3#16% (0 3#90.5#09 -(5@-%-'#1%3 #3 5(&.'%1 %#'=%$ &5(3% '( '=% &%0'%$ B

S .01

S C ($ #0 '=% 6--%$ '=#$1 (< '=% '$.03/%/8$.0% 1(/.#0 B

ζ .01 & γC

/.'&=#09 '=% 5(&.'#(0 (< '=% 8.3#& '$.03/%/8$.0% $%3#16% (0 .&'#7.'#09 $%&%-'($3 BXW XXCB #9* UC* 1.-'($ -(5@-%-'#1%3 .$% .55 1#365-=#1% 5#0?%1 1#/%$3*

#/%$#;.'#(0 (< '=%3% /(5%&65%3 =.3

8%%0 =@-('=%3#;%1 '( (&&6$ '( ./-5#=.' $%#0#'= .&'#7.'#09 $%&%-'($3 B

C*

=% #(0#;.85% $%3#16%3 >#'=#0 '=% '$.03/%/8$.0% 1(/.#03 .$% 36%7%$ '=% $%/.#0#09

'$.03/%/8$.0% $%3#16%3 .$% ?0(>0 '( 36--($' 1#/%$ %%0 =%'%$(5(9(63 3'$.013 B SC* %&%-'($ &(6-5#09 #3 .53( 8%5#%7%1 '( 8% &(01#'#(0%1 8@ '$.03/%/8$.0% 36$$(601#09 $%3#16%3 B

C*

7%0 '=(69= '=% '$.03/%/8$.0%

.3-.$'#& . #3 5(&.'%1 .' '=% 3./% -(3#'#(0 #0 .1.-'($3 8%5(09#09 '( '=% 3./% 9$(6- '=%3% .1.-'($3 1( 0(' #0'%$.&' >#'= '=% 3./% $%&%-'($3*

=63 #0'%$.&'#(03 ./(09 '=% '=$%%

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

'$.03/%/8$.0% =%5#&%3 .$% '=(69=' '( &(0 '=% (6'%$ &%55 /%/8$.0%* .?%0 5%19% &(0&%$0#09 '=% '$.0316&'#(0 -.'=>.@3 #0#'#.'%1 8@

%09.9%/%0' (<

&(6-5%1 $%&%-'($3 =.3 8%%0 1%$#7%1 .@3 6-(0 %09.9%/%0' (< 5%6?(&@'% .1=%3#(0 /(5%&65%3 36&= .3

S B

%5%&'#0

5@&(-$('%#0 #9.01 SCB UC*

-$('%#03 =.7% %7(57%1 '( %0&(1%

11#'#(0.55@ 3(/% 7#$.5

3%H6%0&%3 .3 . /%&=.0#3/ (< -.'=(9%0%3#3* =%3%

-$('%#03 .$% '=(69=' '( 1#3$6-' '=% &.-.&#'@ (< .0'#9%0 $%&%-'($3 '( 3#90.5 0($/.55@ #0 7#$63 #0(651 #'=#0 3&%0.$#( #' #3 &(0&%#7.85% '=.' /(0(-=(3-=($@5.'%1 .0

1(/.#0 &(0'.#0%1 #0

S

3%H6%0&%3* 0 '=#3

3%H6%0&%3 #0'%$.&' -$%#'= '=% 16.5

1(/.#03 (< @? #'= /(0(/%$#& 9

V

&(0'.#0#09

>=%0 8(601 '( 3(5685% 9 * =% 5(>

#016&%3 >%.?

-=(3-=($@5.'#(0

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

$%&$6#'/%0' (< .01

O*

S .01 .3 &(03%H6%0&% #0.&'#7.'#(0 (< '=% %.$5@3#90.5#09 /%1#.'($3 @?

(07%$3%5@ 363'.#0%1 .99$%9.'#(0 (<

&α

8@ /65'#/%$#& 9

.&'#7.'#(0 8@$%&$6#'#09 =#9= ./(60'3 (< @? .01 .8($'#09 =% 3%&(01 /(1%5 %4-5.#0#09

.7.#5.85% 0 '( .33(&#.'% >#'=

S SC* ( 1.'% /($% '=.0 S

%3-%&#.55@ #0 /@%5(#1 &%553

B .85% C* $('%#0

-%&#%3

βS βS

#9.01

V 8 8

6/.0 (63% 6/.0 (63% (63% (63% 6/.0 (63% 6/.0 (63% 6/.0 (63% (63% (63% 6/.0 (63%

M M M M

% 1

6/.0 (63%

M M

#95%& #95%& SV #95%& ST

(63% 6/.0 6/.0

M

#95%& SW #95%& SW

6/.0 (63%

M M

V S S S S

.85% *

4-$%33#(0 B-$%1(/#0.0' &%553C

M M #.5@5.'%1 5#0?%1 369.$3 3#.5@5.'%1 5#0?%1

%096% 7#$63 M M M M 0#(0#& /(5%&65%3

X 5#0?%1 (5#9( %6T %6T & W .5 &.[ %6T &B.5-=.C .5βS V 5&

@%5(#1 &%553 @%5(#1 &%553 @%5(#1 &%553 @%5(#1 &%553 O @%5(#1 &%553 /.3' &%553 @%5(#1 &%553 O @%5(#1 &%553 B/.&$(-=.9%3C @%5(#1 &%553 B/.&$(-=.9%3C @%5(#1 &%553 B/(0(&@'%3 0%6'$(-=#53C @%5(#1 &%553 @%5(#1 &%553 B1%01$#'#& &%553 /#&$(95#.5 &%553C @%5(#1 &%553 B/#&$(95#.5 &%553 /.&$(-=.9% @%5(#1 &%553 @%5(#1 &%553 B3-5%%0 /.&$(-=.9%3C @%5(#1 &%553 @%5(#1 &%553 B/.3' &%553 9$.065(&@'%3 /.&$(-=.9%3 1%01$#'#& &%553C @%5(#1 &%553 B/(0(&@'%3C @%5(#1 &%553 B/.&$(-=.9% 3683%'C &%553 B/.$9#0.5 ;(0%C @%5(#1 &%553 B-5.3/.&@'(#1 1%01$#'#& &%553C @%5(#1 &%553 @%5(#1 &%553 @%5(#1 &%553 @%5(#1 &%553

S .33(&#.'%1 $%&%-'($3 #0 /@%5(#1 &%553* 1.-'%1 .@3 BS

C*

&(0'.#03 .0

.&'#09 .3 . 1(&?#09 3#'% .@3 BS

C*

S

S VC*

.1.-'($ /(5%&65% #0 '=%

'61#%3 #0 /.&$(-=.9%3 =.7% 3=(>0 '=.'

S 3#90.53 .$% .85% '( 1(>0$%965.'% #0=#&= =.7% 0%7%$ 8%%0 #'= 3&5%$(3#09 5%6?(%0&%-=.5(-.'=@ B &.63%1 8@ /6'.'#(03 1#3$6-'#09

C ($

.36

S 9%0% BS

.?(5. 1#3%.3% =.3 8%%0 3=(>0 '( 8% C*

#3 . $%&%33#7%5@ #0=%$#'%1 1#3%.3%

&=.$.&'%$#;%1 8@ . &(/8#0.'#(0 (< -3@&=('#& 3@/-'(/3 $.-#15@ -$(9$%33#09 '( -$%3%0#5% 1%/%0'#. .01 5#-#1#& 8(0% &@3'3 $%3'$#&'%1 '( >$#3'3 .01 .0?5%3*

=% =#&= 6-(0 '@$(3#0%

-=(3-=($@5.'#(0 .55(>3 '=% 8#01#09 (< '=% -XT $%965.'($@36860#' (< &(/-5%4 BSVUC* 3 '=%3% '>( 8#01#09 3#'%3 (7%$5.- . 3#095% ($

$8

86' 0(' 8('= .' '=% 3./% '#/%*

O .01 .

$8

.7S (3

S &=.#0 &.0 8#01 %#'=%$ -XT

6'.9%0%3#3 3'61#%3 =.7% 1%/(03'$.'%1 '=.' '=%

'@$(3#0% $%3#16% #3 %33%0'#.5 =%$%.3 /6'.'#(0 (< '=%

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

.3-.$.9#0% $%3#16% >=#&= .85.'%3 .33(&#.'#(0 >#'= -$%3%0' #0

$8

8#01#09 ($ '=% /%'=#(0#0% $%3#16% >=#&= 1#3$6-'3

O $%365'3 #0 1##'= βS

@V

S %

%7%$'=%5%33 '=% .33(&#.'#(0 (< '=%3%

S #3 /($% %=#5% #'3 1%-=(3-=($@5.'#(0 5%.13 '( .&'#7.'#(0 (< &.'.5@'#& %%0 '=% -=(3-=($@5.'%1

'%$/#063 '@$(3#0% .01 '=%

1(/.#0 (< '=% %0;@/%*

(>%7%$ #0 '=%

#0.&'#7% 3'.'% .11#'#(0.5 #0'$. /(5%&65.$ &(0'.&'3 =.7% 8%%0 (83%$7%1 36&= .3 '=% 8#01#09 (< '=%

?#0.3% 5#0?%$ '( '=%

.01 ?#0.3% 1(/.#03 BSW CB #9* S C* 6'(-=(3-=($@5.'#(0 (< .

&(03%0363 '@$(3#0% #0 '=% ?#0.3% 1(/.#0 %0=.0&%3 '=% &.'.5@'#& .&'#7#'@BT

SWUC*

=% /(3' 3'61#%1 #//60% $%&%-'($3 #0 '%$/3 (< $& ?#0.3% 3#90.5#09 .$% '=% .0'#9%0 $%&%-'($3 (0

.01

5@/-=(&@'%3 B & .01 & C '=% $%&%-'($ #'= 33(&#.'%1

S .01

=(3-=(-$('%#0

C

&(0'%4'*

(03#3'%0'5@ #' =.3

-=(3-=.'.3%3 86' .53( >#'=

B $& 0 .3 5#9.01 0 '( 8#01 '( 3(5685%

1%5#7%$3 . '>( >.@ 3#90.5 '$.0316&'#(0 B S C* 5#9.013 36&= .3 36$=#&= &(0'.#03 '=$%% '@$(3#0% $%3#16%3* B

UC #3 #0 '=% &(0'%4' =#&= =.3 8%%0 3=(>0 '( 8% . 8#01#09 3#'% 3 '=% $%&$6#'/%0' (< 3683%H6%0' 8#01#09 (<

.3

-=(3-=(#0(3#'#1% .01

.01

(? S .01

/(5%&65%3*

(?

.1.-'($ -$('%#03 .01 '=%

=#3 &.63%3 '=% #0=#8#'#(0 (< '=%

O -.'=>.@3 $%3-%&'#7%5@ BX

C*

=63 '=%

#3 .0

#0=#8#'($@ $%&%-'($ '$#99%$#09 /@%5(#1 &%55 #0=#8#'($@ -.'=>.@3 1#3'#0&'#7%5@ =#&= #3 '=(69=' '( -.#$ >#'= '=% 3#90.5 '$.0316&'#(0 .1.-'($ /

. .01 /

8B

C*

S

8@ =(/(5(9@ >#'= #'3 /6$#0% &(60'%$-.$'3

0(651 8% #0&561%1* =% #//60(95(865#0 1(/.#0 (<

$%&%-'($3 #3 #'=#0 '=% =6/.0 $%&%-'($3 .01

S

<

9 >#'=#0 '=%#$ /6$#0% &(60'%$-.$'3 5.&? % 95@&(3@5.'#(0 .&&%-'($ 3#'%3*

V

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

=% /%/8$.0% -$(4#/.5 $%9#(0 (<

$%&%-'($3 &(0'.#03 . =#9= -$(-($'#(0

(< 3%$#0% '=$%(0#0% .01 -$(5#0% $%3#16%3* =#3 -$%1#&'3 '=% /(5%&65%3 '( .1(-' .0 %4'%01%1 &(00 3#0&% 0( '$.03/%/8$.0% .1.-'($ -$('%#03 >#'= (--(3%1 %5%&'$(3'.'#& &=.$9%3 =.7% 8%%0 1%3&$#8%1 '( 1.'%* %9.$1#09 3%H6%0&% =(/(5(9@ & $%&%-'($3 =%$% ($#9#0.55@ $%5.'%1 '( '=% >=#&= &(0'$(53 '=% '$..3 (8'.#0%1 .3 . $%365' (< . @%.3' '=$%% =@8$#1 3&$%%0#09 '(

#1%0'##'=#0 .

5#8$.$@ '=.' &(651 #0'%$.&' >#'= '=%

1(/.#03 (<

S

-=(3-=.'.3% #0 . -=(3-=('@$(3#0% 1%-%01%0' /.00%$ B T C* 0('=%$ 9$(6- $%-($'%1 '=% 3./% 3%H6%0&% .3 9

S

O

B O 0=#8#'($@ %&%-'($C* =#3 3%H6%0&% >.3 $.#3%1 % =.7% 8%%0 .85% '(

9%0%$.'% 3(/% #00*

%7%$'=%5%33 #'3

%4-$%33#(0 #3 /(3' 5#?%5@ '( 8% .53( $%3'$#&'%1 '( '=% /@%5(#1 &(/-.$'/%0'* /(0(&@'%3 .$% -(3#'#7% .3 '=% 3(6$&%

>% 63%1 =#&= %4=#8#' . 1% 1%$#7%1

8 .01

. $%3-%&'#7%5@*

S 3%H6%0&% >=#&=

8 .3 (8'.#0%1 #'=

S B TV

TWC*

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

X =.3 '=% -$('('@-#& 3'$6&'6$% #'= .@3 B T C*

S &(.&'#7.'#09 =#&= .3 1%3&$#8%1

-$%7#(635@ 8%.$3 . 0%9.'#7%5@ &=.$9%1 $%3#16% .01 0( 3#90.5#09 /('##'=#0 '=% #0'$.&%5565.$ $%9#(0* =% 9%0% '=.' %4'%013 (7%$ T ?8 #0 '=% &=$(/(3(/% #3 &(/-(3%1 (< %55 B WSC*

=#3 -$(-%$'@ #3 0(' 3=.$%1 8@ 3-5%%0

/.&$(-=.9%3 >=.' 36--($'3 '=% 3%5%&'#7#'@ #0 /(5%&65.$ .33(&#.'#(03 >#'=#0 '=% &%553 #0 '=% #//60% 3@3'%/* ' #3 #/-($'.0' '( /%0'#(0 '=.' #0 '=%3% &%553 S

& γ =%'%$(1#/%$3*

'=%$ .6'=($3 %4'%01

T

V 1(%3 0(' #0'%$.&' >#'=

V .33(&#.'#(0 '(

S

.1.-'($

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

-$('%#0 86' '=#3 (83%$7.'#(0 =.3 (05@ 8%%0 -%$.3 (8'.#0%1 .$13 ('=%$ 9$(6-3 =.7% $%-($'%1 .01 &=.$.&'%$#;%1 '=% 3./%

3%H6%0&% 8@ -%$=#&= '=% $%&%-'($ /%1#.'%3 '=#3 %0 '( 8% 6-$%965.'%1 6-(0 3'#/65.'#(0

>#'= -$(#00 '( '.?% -5.&% %01(9%0(635@ #0 /.&$(-=.9%3 B WWC* =%$% #3 0( #0( 0%9.'#7%5@&=.$9%1 '$.03/%/8$.0% -$('%#03* (03#3'%0' >#'= '=% $(5% (< .0 .&'#7.'#09 $%&%-'($ -=(3-=($@5.'#(0 (< ?%@ 3#90.5#09 /(5%&65%3 36&= .3 - X 8(0% /.$$(> '$.0316&%1 /.3' &%553 $%5%.3% .01

W .01

OS

T 3'#/65.'#(0 %5#&#'3 + O .01 ?' B WV

T #016&%3 &%55 36$7#7.5 #0 .83%0&% (<

WUC* 0 =#3'./#0%

α &@'(?#0% 3%&$%'#(0 B WVC* =% %

S

.&'#7.'#09

#//60(95(865#0 $%&%-'($ .85% '( '$.0316&% 3#90.53 '=$(69= '>( 1#.3

.85% '( .33(&#.'% >#'=

8.3%1

.1.-'($*

S .01 1%5#7%$ 1##09 $%&%-'($ 3#90.5#09 #01%-%01%0'5@ (<

S *

=%$%%%0 -(3#'#7% .01 0%9.'#7% 3#90.53 1%5#7%$%1 8@ .&'#7.'#09 .01 #0=#8#'($@ $%&%-'($3 (0 '=% 36$( '@-%3 (< '$.03/%/8$.0% .1.-'($ -$('%#03 =.7%

WW

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

8%%0 1%3&$#8%1) '=% ('##55 5%.1 '(

3%&$%'#(0 (< &%55 /%1#.'($3 /#9$.'#(0 -$(5#%$% 9$(>0 #0 -@$67.'% S

T/

%-%3

55 S / (< =

S B

.01

=.$/#09%0

XST

/ -%0#7#0 .01

&65'6$% /%1#. >%$% .11#'#(0.55@ +

_9 / 3'$%-'(/@�*

WU

O B

56'./#0% /%1#6/ 36--5%/%0'%1 956'./#0% S

O

XXWWC

(0( .&WC .01 O XS

&(0'.#0#09 S ] =%.' #0.&'#7.'%1 / -%0#7#0 .01 S

.61#

C* /

U .01

&%553

956'./#0% S/

6/.0

3(1#6/

>%$% (8'.#0%1

8YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

%$% #3(5.'%1 .01 &65'6$%1 .3 1%3&$#8%1 BS C* 0'#

*SS / 8 >.3 .3 -6$&=.3%1 .3 %$% .3 (8'.#0%1 #'= 3%'3 (< /6'.9%0#& (5#9(3 .&&($1#09 '( '=% #03'$6&'#(03 (< '=% Q6#? =.09% #'%

#$%&'%1

6'.9%0%3#3 O#' B '$.'.9%0%

- #3-5.@

8 OSTX

. +(55.

C* - #3-5.@

8 SXX .01

/6'.0'3 >%$% (8'.#0%1 8@ .00%.5#09 (5#9(3

$%3-%&'#7%5@ >#'= '=% - #3-5.@

8 &(03'$6&'*

=% - #3-5.@

V .01 T W

8 OSTX

1(685% /6'.0' >.3 &$%.'%1 8@ .00%.5#09 (5#9(3 T W >#'= '=% - #3-5.@ &(03'$6&'* $%3%0&% (< '=% #0'$(16&%1 /6'.'#(03 >.3 &(0.3 ./-5#.3 9%0%$.'%1 8@ &5(0#09

%-#'(-% #0'( '=%

SXX

.01 &5(0%1 #0'( '=% 95

S..C >.3 ./-5#( 1%5%'#(0 /6'.0'3 (<

8 ..3 ./-5#'

&5(0%1 #0'( '=%

&(

8 SXX

(<

8 OSTX .01

.5 3#'%3 (< - .8% 6$(

- #3-5.@ &(03'$6&'3 63#09 (5#9(3 S '=%

%-#'(-% #0'( '=% ./

- $#19%

8

T S

./-5#.3 1#9%3'%1 >#'=

1 . ) 1/ 0

-$%7#(635@

BSTC*

=%

8 @'( & @0 &.'.5@'#& /6'.0' &(03'$6&'*

,,

&

.5 3#'%3

95 %01(06&5%.3% .01 $%5#9.'%1 #0

&"!

3'$.'%9@ >.3 63%1 '( ./-5#%

%$>.3 &5(0%1 #0'( '=% &(

&.33%''%

SUW Q

($1%$ '( (8'.#0 . - $#19%

3#'%3 (<

* ($ '=% '=$%% =@8$#1 3@3'%/ .33.@ 3%H6%0&% %0&(1#09

8 &@'(-5.3/#& '.#5 (8'.#0%1 63#09 (5#9(3 SV - $#19% & @0V

&(

8 OSTX

7%&'($ 8@

S

5#8$.$@*

60'$.035.'%1 $%9#(03 (<

5#9(3 ST SW #0

8 3%H6%0&% %$% 63%1 .3 ./-5#%$% .3 3) V`

3%& U ` S/#0[ .01 U ` S /#0*

-$(16&'3

>%$% $%3(57%1 #0 . S] .9.$(3% 9%5 .01 7#36.5#;%1 8@ %'=#1#6/ 8$(/#1% 3'.#0#09* 4-%&'%1 3#;% .3 -%$.3 &.$$#%1 (6' #0 -.$.55%5 >#'= (5#9(3 S

W

8YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

*

%'%&'#(0 (<

6/.0

8 >=(5% '$.03&$#-' #0 =6/.0 .01 .3 -%$.3 63%1 0 #0 8(51 5%''%$3* %3'$#&'#(0 3#'%3 63%1 %$% '$.03#%0'5@ '$.03#'= S/9 /

_9 (< 5#0%.$#;%1 %$&65%3

VSX*

C*

VSX B #8&(C*

1(685% '$.03%$% 9%0%$.'%1 3%H6%0'#.55@ .01 /.#0'.#0%1 >#'= S_9 / B #9/.C #0 .11#'#(0 '(

3'.85%

6$(/@�

U &%553 BS TC %$% '$.03.$% B

U

0.5@3#3 >.3 -%$%$% 5@3%1 .' V` -$%7#(635@ BSTC*

1

%$% &5.$#%$% 3%-.$.'%1 8@ %1( .11#'#(0.5 -

%$#//60(-$%&#-#'.'#(03 -$% &5%.$%1 5@3.'%3 >%$% #0&68.'%1 >#'= 8%.13 .01 S_9 (< .0'#8(1@ %

%$(&?.3 63%1 .3 -(3#'#7% &(0'$(5

%$% (8'.#0%1 .3 1%3&$#8%1 B

/%1#6/ >.3 63%1 .3 0%9.'#7% &(0'$(5* C .01 56&#.3 /%.36$%1

.&&($1#09 '( '=% 6.5 6&##'= '=% 3683'$.'%*

US

8YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

)

/ ) ./.

.. /

( &=.$.&'%$#;% '=% #0'%$.&'#(0 8%'>%%0 '=% &@'(-5.3/#& '.#5 (< '=$%% =@8$#1 3@3'%/ .33.@ >.3 &.$$#%1 (6' 8@ &( '$.03% $%&%0'5@ 1%3&$#8%1 . 0(7%5 &%55 36$=#&= #0&561%3 '=% -$%7#(635@ #1%0'#=#&= .

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

=% &

8 9%0% #3 5(&.'%1 .' &=$(/(3(/.5 $%9#(0 SUH T*S* =$(69= .5#90/%0' (<

.01 9%0(/#& 3%H6%0&%3 >% 1%'%$/#0%1 '=% ($9.0#;.'#(0 (< '=% =%

S

8 9%0% B #9 S C*

$65% >.3 63%1 '( 1%#'= C*

TX] >#'=

5(>%$ .5'=(69= 3#90#.3 1%'%&'%1 8%'>%%0 '=% 9 1(/.#03 (< .01

-W

8 .01

BVS] .01 V ] $%3-%&'#7%5@ .5#90/%0'3 0(' 3=(>0C*

&(03%$7.'#(0 (< 0(' (05@ '=% -.#$ (< &@3'%#0% $%3#16%3 1%3&$#8#09 '=% 9

S

('%>($'=@ #3 '=% '@-% =#&= #3 &(03#1%$%1 3@0'%0#& '( =6/.0 &=$(/(3(/% SU*

.> WV*U .3 '%/-5.'%*

WS XC* 5#90/%0' (<

9%0% '( &=$(/(3(/% SS % &5(0%1 .3

%.?5@ #0 8('= '=%

O &%55 5#0%

O .01 '=%

(0 =6/.0

U

&%55 5#0%

S

W .01

XXWW B #9

C*

(>%7%$ >=%0 .33%33#09 '=% -$%3%0&% (< '=% '$.03&$#-' #0 =6/.0 =%/.'(-(#%'#& #3(5.'%1 -(-65.'#(03

8 >.3 .3 (83%$7%1 #0 .&'#7.'%1

1%'%&'%1 '$.03&$#-'3 1#1 #01%%1 &($$%3-(01 '(

O .01

C*

(

&%553* ( %036$% '=.' '=%

8 '=%

-$(16&'3 >%$% &5(0%1 .01

3%H6%0&%1* .3%1 (0 '=%3% 1.'. #' 3%%/3 '=.' %4-$%33#(0 (<

8 #3 $%3'$#&'%1 '( /@%5(#1

5#0%.9%3 .3 >% (83%$7%1 -$%7#(635@%$% .85% '( ./-5# .01 .3 ./-5#%#9=' (<

.--%.$%1 .3 '=$%% 1#3&$%'% 8.013 $.09#09 #0 3#;% .3 0(' =%0 '=% /(5%&65% >.3 %4-$%33%1 #0

,,

.. +

.:

3 &

+

&%553 B1.'. 0(' 3=(>0C*

. /) .

4 .4 )/

) .0 +

7+ .

=% -$%3%0&% (< . -(3#'#7%5@ &=.$9%1 ./#0( . #0 '=% '$.03/%/8$.0% $%9#(0 (< .0 #//60% $%&%-'($ 3'$(095@ 3699%3'3 8#01#09 '( . 3#90.5#09 '$.03/%/8$.0% .1.-'($ /(5%&65% BT WC*

(03#1%$#09 '=.'

8 =.3 . 5@3#0% $%3#16% #0 #'3 '$.03/%/8$.0% -($'#(0 >%

>.0'%1 '( '%3' >=%'=%$ '=% /(5%&65% >.3 .85% '( .33(&#.'% >#'= .0@ 36&= .3

&ε γ .01

S O

'$.03#'=

T C*

>#'=

6$'=%$/(

%$>%3'%$0

-=(3-=($@5.'#(0 (< '=%

85('

.0.5@3#3

8 $%&%-'($*

.0'# -=(3-=('@$(3#0%

S (05@ B #9 / 8

5(> 5%7%5 (< -=(3-=($@5.'#(0 (<

$%7%.5%1 8 >.3

(83%$7%1 #0 '=% -$%3%0&% (< '=% & @0 ?#0.3% .5(0% .01 0(0% >=%0 '=% ?#0.3% >.3 .83%0' 86' #' #0&$%.3%1 1$./.'#&.55@ >=%0 & @0 >.3 &( %4-$%33%1 >#'= βS .01 /6$#0%

36&= .3

O

O#0.3% .33(&#.'%1 .1.-'($ '.99%1

S *

S B #9 T C* (/% $%&%-'($3

.$% .85% '( &(6-5% 0(' (05@ S

B S

C*

% '%3'%1

8 1#1 0(' .33(&#.'% >#'=

S

86' .53( '=%

8 0C* ' =.3 8%%0 3699%3'%1 '=.'

S .&'3 0(' (05@ .3 . 3#90.5#09 /(5%&65% 86' .53( .3 .

&=.-%$(0% .3

%0=.0&%1

*

c * V 73 VS* Xc W*WW]

#0

'=%

8 >.3

-$%3%0&%

(<

d UW*W c V* UC B #9 T C*

S

8

%7%$'=%5%33

B T*XUc U*WV] --(3#'%5@

S

%4-$%33#(0 >.3 0(' /(1#0C* 0&$%.3%1 %4-$%33#(0 (<

8 >.3 0(' 1%'%&'%1 >=%0 '=% $%&%-'($ >.3 &( '$.03%%0 . 8.3#& $%3#16% (0 '=% $%&%-'($ B5@3#0% ($ .$9#0#0%C .01 .0 .#& $%3#16% (0 '=% .1.-'($ -$('%#0 B.3-.$'.'%C BT WC* 3 8 -=(3-=($@5.'#(0 >.3 (&&6$$#09 (05@ #0 '=% -$%3%0&% (< 8('= & @0 .01

S

.11$%33%1 >=%'=%$ '@$(3#0% -=(3-=($@5.'#(0 >.3 $%H6#$%1 % 9%0%$.'%1 . 3%' (<

'.99%1

8 .01

8 /6'.0'3 ..3 0(' %33%0'#.5 =#&=

S

#3 .83%0' B SC B #9 W C*

'$.03% 9%0%$.'%1 .0

'$.03%

%$#/-($'.0' % 9%0%$.'%1 . >#1%$ 3%' (< 8

3'.85@ '$.03%7%$ 8('= 1%5%'#(0 /6'.0'3 3=(>%1 .0 .&'#7.'#09 &.-.&#'@ 3#/#5.$ '( '=%

8 SXX

/6'.0' 3699%3'#09 '=%$% .$% 0( ('=%$ /('#.3

.&=#%7%1 (05@ >=%0 8('= $%3#16%3 OSTX .01 SXX >%$% /6'.'%1 3#/65'.0%(635@ B #9 W C* ( 1#=#&= 1( 0(' %4-$%33 %#'=%$

S 1%-%01%0' '$.03&$#-'#(0.5 .&'#7#'@ >.3 %0=.0&%1 S B #9 U C* ( '%3' >=%'=%$ '=% (83%$7%1 #0&$%.3%

&(651 8% 16% '( '=% &(07%$9%0&% (< '>( -.'=>.@3 #0#'#.'%1 8@

8 >% -%$#'= '=%3% #0'%$-$%'.'#(03 /6'.'#(0 (< '=%

(.

S /%1#.'%1 '$.03&$#-'#(0.5 .&'#7#'@B #9 U C*

. 1) 9 )

.

/

4) . +

S 1%-%01%0' '$.03&$#-'#(0 >.3 .&'#7.'%1 #0 8 #0 '=% -$%3%0&% .01 .83%0&% (< .11#'#(0.5 -.'=>.@3 .&'#7.'%1 8@

0

&%553 8@ %09.9%/%0' (<

S .1.-'($ -$('%#0*

% 1%%1 '( 5((? 0 ($ #0 .33(&#.'#(0 >#'=

S *

.3' &%553 >=%0 %0&(60'%$#09 . -$(-%$ 3'#/6563 .$% .85% '( 3%&$%'% -$('%.3%3 3'($%1 #0 &@'(-5.3/#& 3%&$%'($@ 9$.065%3 B TC*

&%553 .&&6/65.'% β

($ #03'.0&%

=%4(3./#0#1.3% -$('%.3% >=(3% $%5%.3% &.0 8% #016&%1 6-(0 '#/65.'#(0 (<

'$.03.3 /6'.'%1 '( .

0(0 &=.$9%1 ./#0( . $%365'%1 #0 . $%16&'#(0 #0 -$('%.3% $%5%.3% B #9 X C &(0% -%$.3 .3 1%'%&'%1 (05@ >=%0 & @0 ?#0.3%

( #0'%$.&'#(0 >.3 (83%$7%1 >=%0

8 .01 ('=%$ /(5%&65%3 &(0'.#0#09

S VT @%.3' >%$% 1(/.#03 36&= .3

3?

O#0.3% B-XT.5-=. 36860#'C #0 '=% -$%3%0&% (< & @0 B1.'. 0(' 3=(>0C* =% #0'%$.&'#(0

8%'>%%0 8('= /(5%&65%3 >.3 .53( '%3'%1 #0 . /.//.5#.0 3@3'%/ 8@ '$.03=%0 '=% ?#0.3% >.3 &( %4-$%33%1 #0 '=% &%553 B #9

C*

#'= '=% #1%0'# .3 0%%1%1 B #9 U C* .01 #0 '=% .83%0&% (<

S

% =@-('=%3#;% '=.' #0

8 &@'(-5.3/#& -=(3-=($@5.'#(0 $%H6#$%3 '=% 0 /(5%&65%* =#3 /(5%&65% >(651 #0'%$.&' >#'= '=% -(3#'#7%5@ &=.$9%1 $%3#16% #0 #'3 '$.03/%/8$.0% 1(/.#0 3#/#5.$ '( =(> .1.-'($3 ($ 5@3#0% $%3#16% (<

S

8.3%1

8#01 &%55 36$(651 8% '( $%&$6#' '=% ?#0.3%B3C

$%3-(03#85% ($'=@ '=.' '=% 5#0% %4-$%33%3

8 '=$(69=

&ε γ .01

8 >=%0 .33%33%1 #0

S

&%55

.1.-'($3 86' 0%#'=%$ >.3 #'= U &%553 B S VSC* =% -$(-(3%1 &(/-5%4 >=%0 &(6-5%1 '(

'=% $%&%-'($ 3%%/3 .85% '( #01#$%&'5@ .&'#7.'%

U

S 1%-%01%0' '$.03&$#-'#(0* =#3 /.@

8YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

%4-5.#0 >=@

8 '@$(3#0% ($ 1%5%'#(0 /6'.0'3 3'#55 %4=#8#' . 5(> 5%7%5 .&'#7.'#(0 (< '=%

$%-($'%$ 9%0% B #9 U C* 6'6$% 3'61#%3 (0 '=#3 3@3'%/ >#55 '=% -$(&%33 #3 #0(

$8

$8

1(/.#03 5.&?#09 &.'.5@'#& .&'#7#'@ (< #'3 (>0*

(>%7%$

$8

#3 .85%

-(0 $%&%-'($

1(/.#03* #/65'.0%(635@

$8

#3 '=(69='

1(/.#0 '( $%&$6#' ('=%$ 3#90.5#09 /(5%&65%3 '=.' >(651 /%1#.'% . &=.09% #0 '=%

.&'#7.'#(0 3'.'63 (< '=% &%55 BV C* .3

8 #0 .

'$.035(&.'%3 .@ #0 $%3-(03% '( %4'$.&%5565.$ 3#90.53 BSWC* =#3 &(651

%4-5.#0 '=%

8 /%1#.'%1 '$.03&$#-'#(0.5 .&'#7.'#(0 (83%$7%1 #0 (6$ 3@3'%/ (< 3'61@* ' >#55

8% 0%&%33.$@ '( /.- '=% 3#90.5#09 %7%0'3 &(016&%1 8@ $8

6-(0

8 &$(335#0?#09 .01

1%'%$/#0% '=%#$ $%5%7.0&% '( '=% #'=

8 #3 .85% '(

8%.$#09 .1.-'($ /(5%&65% B #9

S (&&6$$%1 #01%-%01%0'5@ (< '=% '@$(3#0% -=(3-=($@5.'#(0 3'.'63 (<

8('= '=% $%&%-'($ .01 '=% .1.-'($ B #9 T &(0.3

&%55 %4-$%33#(0 3@3'%/*

%5%.3% (< -$%.3 -$(/('%1 6-(0 $%&%-'($ 3'#/65.'#(0 '=$(69= #'3 .33(&#.'#(0 >#'= S

.1.-'($*

( =%4(3./#0#1.3% $%5%.3% >.3 (83%$7%1 #0 '=% .83%0&% (< '=% .1.-'($

/(5%&65% ($ >=%0 #'3 $%&$6#'/%0' >.3 1#3$6-'%1 B #9 XC* .85% '( .&'#7.'%

S &(/-5%4 >.3 .53(

S 1%-%01%0' '$.03&$#-'#(0.5 .&'#7#'@ B #9 U C* =% (83%$7%1 3#90.5

>.3 9%0%$.'%1 %4&563#7%5@ '=$(69= 8@ '=%

8

8%.$#09 .1.-'($ .01

S

.01 0(' .3 . &(/8#0%1 %=%0 0( #0'%$.&'#(0 >#'= '=% .1.-'($ '=$(69= '=%

'$.03/%/8$.0% 5@3#0% '((? -5.&% B #9 T C* =%3% 1.'. 3699%3' '=.' #0 .85% '( /(165.'% '=% 5%7%5 (< '@$(3#0% -=(3-=($@5.'#(0 (<

U &%553

S #3

8 #01#$%&'5@ '=$(69= #'3

#0'%$.&'#(0 >#'= ('=%$ /(5%&65%3 36&= .3 . 3%&(01 3%' (< ?#0.3%3* 0('=%$ -(33#8#5#'@#3 '=.' '=% #0'%$.&'#(0 8%'>%%0 5@3#0%*

8 .01

S

1(%3 0(' $%5@ %4&563#7%5@ (0 '=% '$.03/%/8$.0%

($ #03'.0&% #' =.3 8%%0 1%/(03'$.'%1 '=.' '=%

/(5%&65% 8#013 '=% & @0 (< '=% #//60% $%&%-'($

1(/.#0 (< '=%

1(/.#0 .01 1#$%&'5@ &(6-5%3 '=#3 ?#0.3% '( '=% &@'(-5.3/#& '.#5 ST

-$(/('#09

ST

'@$(3#0% -=(3-=($@5.'#(0 BVTC*

%4-%$#/%0'3 .$% 0%%1%1 '(

8 -=(3-=($@5.'#(0*

8 #' >#55 8% 0%&%33.$@ '( =#&= 8('= '=% $%&%-'($ .01 3=(>0 '( 8% %4-$%33%1 .01 ( $%&%-'($3 /6$#0% '.#5 B #9

%3-#'% '=% =#9= 1%9$%% (< =(/(5(9@

8 5.&?3 '=% '@$(3#0% 8.3%1 /('#< (< '=% &@'(-5.3/#&

C* =% /6$#0% #55 8% %33%0'#.5 >*%03%/85*($9

*

%$7%$ .' =''-) >>>*&83*1'6*1? 3%$7#&%3 #90.5

%0% %4-$%33#(0 %$7%$ .' =''-) 3@/.'5.3*90.@3* *

* +.0%>.@* &

S

* 00.'% #//60% $%&(90#'#(0) /%&=.0#3/3 .01

SU )X

U* * //60% #0=#8#'($@ $%&%-'($3* +

.7%'&= +* * .01 * * .0#%$*

+

)XV

X * *

%#55%''%

*

*

.'(6$

.01

#%.@3*

* #'.5%

*

* %01%

*

.0'(0#

9&

*

*

*

.?./6$.

*

?#55%$ &%553*

*

*

.@5($

*

9 (33%5#0 +*

X*

V

V *

=.09

* +*

#%'$#&=

*

*

*

57.$%; $$#&(

* +*

U S*

96#5.$

*

*

SW )VWTS VWTV*

*

*

* O#';#9

57.$%; $$#&(

(-%; ('%'*

V*

* O*

* *

01%$3(0 +*

*

* (''#0(

* %01%

*

*

* *

*

.61%

*

* (?%

6''#09 %19%) O

S

* O#09 . 0(7%5

S 86' >#'= 60#H6% 3#90.5#09

$&?.5( +* .@(3 .01

* (-%; ('%'*

*

.$&#.

(0'%$(

*

9

$. .01 +* .>.1.*

S*

&@'(3(5#& &.5/ &(0&%0'$.'#(0 .01 1%9$.065.'#(0 #0

U*

([email protected]

*

.$8. '=%

* * =(%53(0 +*

* .8%

*

& 5.1%

.0.#'= #'3 /6$#0% ($'=(5(9 /

-W

.01

O-VVC* 1%0'#&.5 $%3#16%3 .

%$(03%$7%1 &@3'%#0% $%3#16%3 .$% /.$?%1 >#'= B

WS XC* =% %0'#$% /(5%&65% #3

$%-$%3%0'%1* 1%0'#&.5 ./#0( . .$% 3=(>0 (0 . 85.&? 8.&?9$(601 .01 &(03%$7.'#7% &=.09%3 (0 . 9$.@8.&?9$(601*

X

8YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

C

C

C

#9 *

8/

#3 %4-$%33%1 /.#05@ #0 =6/.0 /@%5(/(0(&@'#& &%553*

=%/.'(-(#%'#& &%55 5#0%3 B C %$% '$.03%

%$ 8YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

C

C

#9 T*

8 -=(3-=($@5.'#(0 .01 .33(&#.'#(0 >#'= %4'$.0 /%'=(1 >#'=

'.99%1

5@3.'%3 >%$% #//60(-$%&#-#'.'%1 >#'= .0'# $('%#03 >%$% '$.03#'=

/(5%&65%3* 6$.3 /(0#'($%1 8@ &@'(/%'$@ 63#09

ζ*

'.99%1 .1.-'($

T / 8 0C .01 .0 #3('@-#& / 8 .3 . 0%9.'#7% &(0'$(5 B>=#'% =#3'(9$./C* =% $%365'3 3=(> . $%-$%3%0'.'#7% %4-%$#/%0' (< '=$%% -%$#'=

'.99%1

5@3.'%3 >%$% #//60(-$%&#-#'.'%1 >#'= .0'# $('%#03 >%$% '$.03%$% -%$%$% 3'#/65.'%1 >#'= '=% #01#&.'%1 .0'#8(1#%3*

=%4(3./#0#1.3% $%5%.3% >.3 .33%33%1 8@ #0&68.'#09 '=% 36-%$0.'.0' >#'= V 0#'$(-=%0@5

.&%'@5 β

&%553 %4-$%33#09 %$&%0'.9% (< 956&(3./#0#1%

3683'$.'%* %365'3 .$% %4-$%33%1 .3 . -%$&%0'.9% (< 3-%&#=%$% .83 3-(0' #3 '=% 3-(0'.0%(63 $%5%.3% (8'.#0%1 >#'= &%553 #0&68.'%1 #0 .83%0&% (< 83 .01 .83 /.4

#3 '=% /.4#/6/ $%5%.3% (8'.#0%1 >#'= &%553 5@3%1 63#09

4S

*

-(0'.0%(63 .01 /.4#/6/ $%5%.3% 1#1 0(' 1##'=

$8

#0 . -=(3-=('@$(3#0% 1%-%01%0' >.@*

C =$%% =@8$#1 3@3'%/ #0 @%.3'*

.3 3683'$.'% '( /%.36$% β 9.5.&'(3#1.3% .&'#7#'@>.3 63%1 '( 3&($% '=% #0'%$.&'#(0 (<

8 &@'(-5.3/#& '.#5 #0 '=% -$%3%0&% (< & @0

$8

($ . & @0 &.'.5@'#& /6'.0'* ($ %.&= &(03'$6&' '=$%%

#01%-%01%0' &(5(0#%3 >%$% '%3'%1 #0 '=% 9.5.&'(3#1.3% .33.@*

=% $%365'3 .$% $%-$%3%0'.'#7% (< '=$%% #01%-%01%0'

%4-%$#/%0'3* C

8

U &%553 >%$% '$.03#%0'5@ '$.03.3 #//60(-$%&#-#'.'%1*

.5(0% ($ >#'= & @0 ?#0.3%* 01(9%0(63

%3'%$0 85('3 >%$% &.$$#%1 (6' >#'= '=% #01#&.'%1 .0'#8(1#%3*

U

$8

X

$'#&5% =% #//60% $%&%-'($3

($? >% 3=(> '=.' & . /(5%&65% 8%.$#09 . 0%9.'#7% &=.$9% >#'=#0 #'3 '$.03/%/8$.0% 1(/.#0 #3 .85% '( 1%5#7%$ .&'#7.'#09 3#90.53 #0 '=% '$.03%%0 '=%/*

6$-$#3#095@ '=% .33(&#.'#(0 >.3 0(' 1%-%01%0' (0 '=%

&=.$9%3

'$.03/%/8$.0%

>#'=#0

'=%

$%&%-'($3D

$%9#(03

86'

(0

#//60(95(865#0 1(/.#03* 0 .11#'#(0 >% 1%/(03'$.'%1 '=.' .55

'=%

%4'$.&%5565.$

/%&=.0#3/ #'=#0 '=%#$ 5(09 &@'(-5.3/#&

3 8%&(/% '@$(3#0% -=(3-=($@5.'%1 .01 '=%$%.#'= 3-%&#.5#;%1 3#90.5 '$.0316&'#(0 '$.03/%/8$.0% -(5@-%-'#1%3 8%&.63% (< '=% 5.&? (< #'=#0 '=% $%&%-'($ .01 '=% .1.-'($ -(5@-%-'#1%*

#9.01 %09.9%/%0' (<

.&'#7.'#09 $%&%-'($3 $%365'3 #0 '=% -=(3-=($@5.'#(0 (< '@$(3#0% 8.3%1 /('#'= /%&=.0#3/ '( -$%%5@ &(0'$(5 #//60% 3#90.5#09* =% #'=

956'./#0% S

/5 -%0#7#0 .01 S

&%553 >%$% 9$(>0 #0

956'./#0% S/

3(1#6/ -@$67.'% S

*SS / 8 >.3 .3 -6$&=.3%1 #'= /6'.9%0#& (5#9(3 T .01 W .&&($1#09 '( '=% #03'$6&'#(03 (< '=% Q6#&? =.09% #'%

#$%&'%1

>.3 &(0#'= .0

%.1@ $%.&'#(0 ?#' B --5#%1

#(3@3'%/3C*

#9

@%3 %$/#0.'($

>( 1%5%'#(0 /6'.0'3 (<

& .( ./

@&5% %H6%0

&

.01

& ∆&@'( >%

%$./-5#%$% 1%3&$#8%1 8%%$% 368&5(0%1 #0'( '=% ./

7%&'($ 8@

8 OSTX .01

&(

./-5#.3 368&5(0%1 63#09 '=% 3./% 3'$.'%9@ 86' 63#09 '=% ./

*

63#09 (5#9(3 S SS .01 &5(0%1 #0'( '=%

%H6%0&%3 %0&(1#09 #'= (5#9(3 &(6-5%1 '( $%3'$#&'#(0 3#'%3 .3 ./-5#.

* ?.>.

*

?.1. .01

(03'#'6'#7% .&'#7.'#(0 (< $& 0

* 5#3=?.

* 6&?5%$

=#'% .01 *

%< #0#'= & $%&%-'($

9.//. &=.#0* 8 "(4 ! SV *

*

9

S* &'#7.'#09 $%&%-'($3 .01 &($%&%-'($3 #07(57%1 #0 =6/.0 0.'6$.5

?#55%$ &%55 /%1#.'%1 &@'(5@3#3* SVS*

* %01%

C* 8

* * .01

>#'= .$9#0#0%BW /.&$(-=.9%3*

*

SXX) S *

T*

& #&.$* S

* 60&'#(0.5 .33(&#.'#(0 (< &%-3#5(0 9.//.

C (< -.#$%1 #//60(95(865#0 5#?% $%&%-'($ B V)SU

SU W*

SUV

C

#0 /6$#0%

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

SV *

O.0.;.>.

*

O*

.3=#$(

O*

0.8.

#//60(.&'#7.'#09 $%&%-'($ . 0(7%5

.01

*

#@.&=#*

*

%01$#'#& &%55

'@-% 5%&'#0 #//60($%&%-'($ .&'3 .3 .0

.&'#7.'#09 $%&%-'($ '=$(69= .33(&#.'#(0 >#'= & $%&%-'($ 9.//. &=.#0* 8 UX) WVT SVV*

(5(00.

WT * *

*

.?.I#/.

9 5#?% $%&%-'($3 #I?

*

* *

TU)SWS SWV*

&%55 1%7%5(-/%0' #3 .8(5#3=%1 #0 /#&% 5.&?#09 8('= &? .01 @0 -$('%#0 '@$(3#0%

#883

* *

*

#3=#;6/#

(00(55@ .01 *

* .$5#0'(0 +* 600* S

* * .0#6&=#

.01 * ././('(* S

T*

$/%3

*

$.#5

*

*

*

(193(0

%4#1(

*

* ./.0.3=#

* O#'./6$.

* 5#&

(0'9(/%$@ *

*

6

.I%>3?@ .01

*

.$.?=(73?@*

'%#0

* *

%&?5%08$.6?%$ O* *

(>%55

* (9%5 .01 * ($#.0(* S

* *

* ($#.0( .01

(>%55

*

*

*

*

.#I(

=%

.'.0.8%

S* .$9%'%1 1#3$6-'#(0 (<

*

WV)W *

V*

U

.5%?

&%55 3-%&#%55

* *

&$#'#&.5 $(5%

* ($8%3

* %&? .01 +* $(>31.5%*

* =% =6/.0

9%0% &563'%$ .' W- S*S %0&(1%3 8('= .&'#7.'#09 .01 #0=#8#'($@ 3#095% 9 O-VV* "9)8

1(/.#0 $%&%-'($3 .01 #0&561%3 S

*

%//# *

* +* 1(@.9. O* 61.

'%#0/.0*

*

'$#99%$#09 $%&%-'($ %4-$%33%1 (0 /@%5(#1 &%553 B $%/C

$%/ 5#?% V 8#013 '( 1%.1 &%553 .01 #3 .

.&'#7.'#(0 -$('%#0 S

5#0?%1 /.$?%$ *

X V*

* *

* 3'(65

%19%)

*

W* =%

$%&%-'($ 3*

*

=.$.&'%$#;.'#(0 (<

.0 .&'#7.'#09 $%&%-'($ (0 /(63% /.&$(-=.9%3) 1%3

S

*

(7%3'

* 7(0 .01%08%$9

* 655./

*

*

#%/#

* *

* &=#51 .01

g #.@%

=%0

* O* &=.( .01

*

*

* * $.01. *

*

* * $.01.

%./.0*

*

%7.$%;

*

*

(5(00.

*

*

*

(&=$.0%

*

7.0 1%0 %$9 +*

(>.$1

* O*

*

* 7.0 %%?

* O.369.

#90%$@ * #7#%$

*

* #6 $#9='

*

9

.$&5.@

*

* .01

$%965.'#(0* % SS*

6I#(?. 361.

*

*

&

.'(;.?#

*

*

.'(;.?#

* .?.1. .01

'=.' 8#013 '=%

W* =%

O=.$#'(0%0?(7

* T* #90.5

*

(5(00.

%%5

*

./.96&=#

* .$?(3

* .$&5.@* 9

*

T*

* .0(

*

*

0(/%0&5.'6

%$SUT)UUXX UUX * 0* 9

SXV) ST

SUT)UUXS UUXU*

* +* 6=$#09

#'= SUS)

*

* #95%$

* 8

9

*

YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY

*

=.09

* .01 +*

*

=#55#-3*

W* 1%0'##03?#

9

(/(5.

$%&%-'($* 8

* *

6$-=@ *

* %19>#&? +* # .01 *

+ $ * +*

S V)SVV W SVVVS*

$#9='

* $(>0

*

*

(11.$1

*

* 6$.>3?#

* .$&5.@ .01 +*

5.$?

+

*

*

.?.'36

603'%$

* O*

& .

9

/%/('( .'36/('(

.3% *

*

636<

.01

($?3=(*

*

*

.$'*

T*

*

=3=#/. O*

W*

#9='=

*

*

* +.09

&(0'.#0#09

*

.0'#9%0 5#?% #'=

././('( .01

S*

* %19>#&?*

/(165.'% 8(0% /.33 7#. '=%

+

* +* '$%#'

#/.0 +*

6.$'.3 +* O% Q* =.09 U*

(%? *

(09

*

#90%$@*

X*

*

* =.09 +*

W* %965.'#(0 (< /@%5(#1 &%55 #'= . 1(/.#0 3#/#5.$ '( '=% -(5@ 9 $%&%-'($* 9 V *

.#3=

S )X S X *

.$'* S

*

*

* '.$5#09 +* *

&O%0;#% +*

*

4-$%33#(0 (< '=%

V *

.0'(0# #'.5%

#//(

T .0'#9%0

#//60(95(865#0 9%0% 36-%$ /%/8%$ (< '=%

#3 1#.

*

* ./.;.?#

.'361.

*

* %0%0

* .=.$.

.0.(?.

* >./.

*

*

(01.

.?.6&=# .01

=#86@.*

* .#$%1 .&'#7.'#09 .01 #0=#8#'($@ #//60(95(865#0 5#?% $%&%-'($3

.01

$%965.'% /.3' &%55 .01 /.&$(-=.9% .&'#7.'#(0* 8 "(4 !

*

S X)

* TT*

O6/.9.#

*

*

?# O* ./#'36

O.>.?./# O*

.9.@(3=#

* * %09

*

*

O.>.?./# .01 * O#'./6$.*

TW*

60#';

0(

(-%5.01

*

* +*

.?.I#/.

#58%$'

*

*

* .(

*

* +%0?#03

*

* 1%0'##&; * .?.# .01 *

.?.0(

=#86@.*

#//60(95(865#0 5#?% $%&%-'($

S

* =#8.'.

C .0 #0=#8#'($@ #//60(95(865#0 5#?% $%&%-'($ (0 /@%5(#1 &%553* 8

=#86@. .01

WX*

?#

SX ) U S *

.?.0(

WU*

*

.6&=#03

X )SU

.0.(?. O*

B

WW*

.'36(?.

U* 60&'#(0.5 .0.5@3#3 (< .&'#7.'#09 $%&%-'($

(01. O*

9

*

.%1. ././('( +* *

#0=#8#'($@$%&%-'($ .0 *

X* 4-$%33#(0 (< . 3-5# #3(. O* +* O#'.6$.

WT*

S X) WUX WXW*

.0.(?. .01 * =#86@.*

B

/) WV*

&%55 $%3-(03%3*

* * +* * *

$#9='

%0'%$ .01 *

*

.$?#*

U*

#95%&3 .01 '=%#$ $(5%3 #0 '=%

U) TT WW* .>

*

%5/3

* (>&(&?*

SXW

*

6.0

*

.(

* .#55(0

#55%$

*

*

(7%5 #//60(95(865#0 36-%$$%0&% *

*

* * 8%&.3#3

$%/8.'=

*

*

* +*

.55%@

(%55

* 58.0# +* *

* $#19%3 +$* .55.=.0

* * /(3 %53(0

* * #3%'3?@

* 5%//#09

* *

*

*

*

*

*

.$1

=%0

* =#9%'. +*

5%99

* (-%

* * O.3'0%$

%0%$ .01 * O*

*

* *

(0'%#$(

* O%$0

* &=$(%1%$ +$* #51%$

$%9%$3%0*

* #0&63

S*

*

* *

9%0(/%>#1%

3&$%%0 #0 /65'#-5%4 $=%6/.'(#1 .$'=$#'#3 #'= ('=%$ 8 9 '

.6'(#//60% 1#3%.3%3* UW*

($1(0

* .01 * * .@5($*

& UU*

9

T) T

.$'#0%; *

*

.$'#0%;

*

W*

(0(&@'% .01 /.&$(-=.9% =%'%$(9%0%#'@* %

T*

WV* * #&.

*

.01 -(5.$#;.'#(0* *) UX*

WX) U

*

.0'(7.0# .01

* (&.'#*

X*

.+ S )VT VWS* *

%5/#09 .01

*

($1(0*

X*

(33%$

*

U ) X *

*

5'%$0.'#7% 9&

.&$(-=.9%3) 0 //60(5(9#& 60&'#(0.5 %$3-%&'#7%* U *

.&$(-=.9% .&'#7.'#(0

&'#7.'#(0 (<

9

*

=% /.0@ #'= 36860#'3 &(//(0 UV)

* .01 * O*

9

*

XX

$%>.5*

W* .//.5#.0 95@&(3@5.'#(0 #0 #//60#'@* %

X*

&

X)XUV XXU*

5(/

*

*

#&=%$#'; (0'%0

*

6-'.

*

.//%5'(( X *

*

+. V)SW

*

$%9(#

%$9

* #$.3

&%55 $%&%-'($ $%&(90#'#(0 (< S )X XU*

*

.5#33%0 .01 +*

U* =% '=$%% 1#/%03#(0.5 3'$6&'6$% (< .

&%55 .0'#9%0 $%&%-'($

S*

6

*

*

* O>(09 .01

*

*

%01$#&?3(0* S

-$#09%$

* * .01 +*

*

.09*

U*

V* % 9)

#/%$#& .33(&#.'#(0 .01 XU)T U T

WX)

)

W *

=#%513

* +*

*

33%%%0

&5.33

* O*

9

SW )

.?(3

* *

U

#8.61(* S

X*

36860#'3) . 3@3'%/.'#&

.--$(.&= U)SS

T*

*

9

SUU)U

U SS*

W* #-#1 $. @(6 1(0g'* %

*

9

SSV *

#&=%5

* .01

* .?(7#&*

U* #-#1 $.%55

* *

% $.0&( .01

S $%965.'%3 $&

Helpful Links

Smile Life

When life gives you a hundred reasons to cry, show life that you have a thousand reasons to smile

Get in touch

© Copyright 2015 - 2024 PDFFOX.COM - All rights reserved.