Oncotarget | Vol 8, No 32 - Impact Journals [PDF]

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Vol 8, No 32 AUGUST 8, 2017 Editorial Priority Research Papers Research Papers: Immunology Research Papers: Autophagy and Cell Death Research Papers Meta-Analysis Clinical Research Papers Reviews Meta-Analysis Corrections View Archive » Order a Reprint ABOUT THE COVER The cover for issue 32 of Oncotarget features Figure 7E, "A graphic model describing assay development, drug discovery and mechanistic studies with statins," from Villarino, et al.

TABLE OF CONTENTS Editorial Targeting TRIB3 and PML-RAR interaction against APL

Autophagy and Cell Death

https://doi.org/10.18632/oncotarget.19442

Chromosome

Ke Li, Feng Wang, and Zhuo-Wei Hu

52012-52013 PDF | Order a Reprint

Testimonials from Authors

Indole microbial metabolites: expanding and translating target(s) https://doi.org/10.18632/oncotarget.19443 Sridhar Mani

52014-52015 PDF | Order a Reprint

Priority Research Papers Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells Employment opportunities HR Generalist Read more and apply now Assistant Editor Read more and apply now English Editor Read more and apply now Production editor Read more and apply now

https://doi.org/10.18632/oncotarget.18152 Nathan De Beule, Eline Menu, Mathieu J.M. Bertrand, Mérédis Favreau, Elke De Bruyne, Ken Maes, Kim De Veirman, Magdalena Radwanska, Afshin Samali, Stefan Magez, Karin Vanderkerken, and Carl De Trez

52016-52025 Abstract | PDF | HTML | Order a Reprint Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase https://doi.org/10.18632/oncotarget.19036 Ellen L. Weisberg, Alexandre Puissant, Richard Stone, Martin Sattler, Sara J. Buhrlage, Jing Yang, Paul W. Manley, Chengcheng Meng, Michael Buonopane, John F. Daley, Suzan Lazo, Renee Wright, David M. Weinstock, Amanda L. Christie, Kimberly Stegmaier, and James D. Griffin

52026-52044 Subscribe to TOC Alerts

Abstract | PDF | HTML | Supplementary Information | Order a Reprint

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Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc- receptor engagement

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https://doi.org/10.18632/oncotarget.19090 James Bradford Kline, Rina P. Kennedy, Earl Albone, Qimin Chao, Shawn Fernando, Jennifer M. McDonough, Katherine Rybinski, Wenquan Wang, Elizabeth B. Somers, Charles Schweizer, Luigi Grasso, and Nicholas C. Nicolaides

52045-52060 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Therapeutic vaccine to cure large mouse hepatocellular carcinomas https://doi.org/10.18632/oncotarget.19367 Zhen Han, De Yang, Anna Trivett, and Joost J. Oppenheim

52061-52071 Abstract | PDF | HTML | Order a Reprint

Research Papers: Immunology The “4 plus 2” rituximab protocol makes maintenance treatment unneeded in patients with refractory ANCA-associated vasculitis: A 10 years observation study https://doi.org/10.18632/oncotarget.18120 Dario Roccatello, Savino Sciascia, Daniela Rossi, Mirella Alpa, Carla Naretto, Massimo Radin, Roberta Fenoglio, Simone Baldovino, and Elisa Menegatti

52072-52077 Abstract | PDF | HTML | Order a Reprint

Research Papers: Autophagy and Cell Death Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury https://doi.org/10.18632/oncotarget.19107 Zipeng Zhou, Chang Liu, Shurui Chen, Haosen Zhao, Kang Zhou, Wei Wang, Yajiang Yuan, Zhuo Li, Yue Guo, Zhaoliang Shen, and Xifan Mei

52078-52093 Abstract | PDF | HTML | Order a Reprint

Research Papers Prognostic value of a systemic inflammatory response index in metastatic renal cell carcinoma and construction of a predictive model https://doi.org/10.18632/oncotarget.10626 Liangyou Gu, Xin Ma, Lei Wang, Hongzhao Li, Luyao Chen, Xintao Li, Yu Zhang, Yongpeng Xie, and Xu Zhang

52094-52103 Abstract | PDF | HTML | Supplementary Information | Order a Reprint 5-aza-2’-deoxycytidine (DAC) treatment downregulates the HPV E6 and E7 oncogene expression and blocks neoplastic growth of HPV-associated cancer cells https://doi.org/10.18632/oncotarget.10631 Maximilian Stich, Lennard Ganss, Jens Puschhof, Elena-Sophie Prigge, Miriam Reuschenbach, Ana Guiterrez, Svetlana Vinokurova, and Magnus von Knebel Doeberitz

52104-52117 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway https://doi.org/10.18632/oncotarget.10130 Poyil Pratheeshkumar, Young-Ok Son, Sasidharan Padmaja Divya, Lei Wang, Lilia Turcios, Ram Vinod Roy, John Andrew Hitron, Donghern Kim, Jin Dai, Padmaja Asha, Zhuo Zhang, and Xianglin Shi

52118-52131 Abstract | PDF | HTML | Order a Reprint Combined CT-guided radiofrequency ablation with systemic chemotherapy improves the survival for nasopharyngeal carcinoma with oligometastasis in liver: Propensity score matching analysis https://doi.org/10.18632/oncotarget.10383 Wang Li, Yutong Bai, Ming Wu, Lujun Shen, Feng Shi, Xuqi Sun, Caijin Lin, Boyang Chang, Changchuan Pan, Zhiwen Li, and Peihong Wu

52132-52141 Abstract | PDF | HTML | Order a Reprint

Analysis of ESR1 and PIK3CA mutations in plasma cell-free DNA from ERpositive breast cancer patients https://doi.org/10.18632/oncotarget.18479 Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Mai Tomiguchi, Aiko Sueta, Keiichi Murakami, Yoko Omoto, and Hirotaka Iwase

52142-52155 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Lower Beclin 1 downregulates HER2 expression to enhance tamoxifen sensitivity and predicts a favorable outcome for ER positive breast cancer https://doi.org/10.18632/oncotarget.11044 Yu Gu, Tianxiang Chen, Guangliang Li, Cong Xu, Zhenzhen Xu, Jing Zhang, Kuifeng He, Linyan Zheng, Zhonghai Guan, Xinyun Su, Jiang Cao, and Lisong Teng

52156-52177 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Hepatic NK cell-mediated hypersensitivity to ConA-induced liver injury in mouse liver expressing hepatitis C virus polyprotein https://doi.org/10.18632/oncotarget.11052 Qiuxia Fu, Shaoduo Yan, Licui Wang, Xiangguo Duan, Lei Wang, Yue Wang, Tao Wu, Xiaohui Wang, Jie An, Yulong Zhang, Qianqian Zhou, and Linsheng Zhan

52178-52192 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Association of high microvessel v3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126 https://doi.org/10.18632/oncotarget.13386 Anat Erdreich-Epstein, Alok R. Singh, Shweta Joshi, Francisco M. Vega, Pinzheng Guo, Jingying Xu, Susan Groshen, Wei Ye, Melissa Millard, Mihaela Campan, Guillermo Morales, Joseph R. Garlich, Peter W. Laird, Robert C. Seeger, Hiroyuki Shimada, and Donald L. Durden

52193-52210 Abstract | PDF | HTML | Order a Reprint The pseudogene derived long noncoding RNA DUXAP8 promotes gastric cancer cell proliferation and migration via epigenetically silencing PLEKHO1 expression https://doi.org/10.18632/oncotarget.11075 Hong-Wei Ma, Min Xie, Ming Sun, Tian-Yu Chen, Rong-Rong Jin, Tian-Shi Ma, Qin-Nan Chen, Er-Bao Zhang, Xue-Zhi He, Wei De, and Zhi-Hong Zhang

52211-52224 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Nurse-like cells promote CLL survival through LFA-3/CD2 interactions https://doi.org/10.18632/oncotarget.13660 Frédéric Boissard, Marie Tosolini, Laetitia Ligat, Anne Quillet-Mary, Frederic Lopez, JeanJacques Fournié, Loic Ysebaert, and Mary Poupot

52225-52236 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer https://doi.org/10.18632/oncotarget.11111 Carolina Soekmadji, James D. Riches, Pamela J. Russell, Jayde E. Ruelcke, Stephen McPherson, Chenwei Wang, Chris M. Hovens, Niall M. Corcoran, The Australian Prostate Cancer Collaboration BioResource, Michelle M. Hill, and Colleen C. Nelson

52237-52255 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Adult T cell leukemia aggressivenness correlates with loss of both 5hydroxymethylcytosine and TET2 expression https://doi.org/10.18632/oncotarget.13665 Ambroise Marçais, Laetitia Waast, Julie Bruneau, Katia Hanssens, Vahid Asnafi, Philippe Gaulard, Felipe Suarez, Patrice Dubreuil, Antoine Gessain, Olivier Hermine, and Claudine Pique

52256-52268 Abstract | PDF | HTML | Supplementary Information | Order a Reprint The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study https://doi.org/10.18632/oncotarget.13699 Peter Tan, Ing Soo Tiong, Shaun Fleming, Giovanna Pomilio, Nik Cummings, Mark Droogleever, Julie McManus, Anthony Schwarer, John Catalano, Sushrut Patil, Sharon Avery, Andrew Spencer, and Andrew Wei

52269-52280 Abstract | PDF | HTML | Supplementary Information | Order a Reprint The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells https://doi.org/10.18632/oncotarget.12595 Maria Celia Fernandez, Roni Rayes, Boram Ham, Ni Wang, France Bourdeau, Simon Milette, Martin lllemann, Nigel Bird, Ali Majeed, Jun Xu, Tatiana Kisselova, and Pnina Brodt

52281-52293 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Suppression of microRNA-205-5p in human mesenchymal stem cells improves their therapeutic potential in treating diabetic foot disease

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Interviews with outstanding authors Editors-in-Chief Andrei V. Gudkov Roswell Park Cancer Institute, Buffalo, NY

Andrei V. Gudkov, PhD, DSci, Professor and Garman Family Chair in Cell Stress Biology, Senior Vice President for Basic Research of Roswell Park Cancer Institute (RPCI), Buffalo, NY His academic degrees in experimental oncology and molecular biology were received in former USSR from National Cancer Center and Moscow State University. He is co-founder and Chief Scientific Officer of Cleveland BioLabs, Inc and Tartis, Inc. His area of general research interest includes drug discovery, gene discovery, molecular targets for cancer treatment. Mikhail V. Blagosklonny Roswell Park Cancer Institute, Buffalo, NY

Mikhail V. Blagosklonny, M.D., Ph.D., Professor, Roswell Park Cancer Institute, Buffalo, NY Dr. Blagosklonny is the author of over 250 articles in peer-reviewed journals. He has served as Associate Editor of Cancer Res, Cell Death Differ, Cancer Biol Ther, Autophagy, Int J Cancer, Am J Pathology, PLOS ONE and as Editorin-Chief of Cell Cycle. His research interests range from molecular and cellular biology to clinical investigations. Recently, he extended the study of signal transduction pathways from cancer to aging, revealing potential targets for slowing down aging and age-related diseases. Editorial Board Cory Abate-Shen Columbia University, NY, NY

Cory Abate-Shen, PhD, Professor, Director of Research, Department of Pathology, Associate Director, Herbert Irving Comprehensive Cancer Center, Columbia University, NY Frederick Alt Harvard Medical School, Boston, MA

Frederick W. Alt, Ph.D., member of the National Academy of Sciences, Professor, Harvard Medical School Dr. Alt is also Investigator, Howard Hughes Medical Inst., Charles A. Janeway Professor of Pediatrics, HMS, Scientific Director, CBRI Institute for Biomedical Research.Fred Alt received a PhD from the Department of Biological Sciences at Stanford University. He is a Howard Hughes Medical Institute investigator, a member of the National Academy of Sciences and the American Academy of Sciences. He is the recipient of He is the recipient of the 2003 Excellence in Mentoring Award from the American Association of Immunologists and the 2004 Clowes Memorial Award from the American Association of Cancer Research. Editorial Boards: Mol. and Cell. Biology; Advances in Immunology; International Immunology; J. Exp. Med.; Current Opinion in Immunology; Immunity (founding Co-editor; 1993-present); Molecular Medicine (Contributing editor; 1997-present); Faculty of 1000 (co-head, Immunology). Honors and Awards: Fox Award, Stanford Univ. (1973); Hirschl Award (1983); Searle Scholar; (1983) Mallinckrodt Scholar; (1984); NIH Merit Award (1991); National Academy of Sciences (1994); American Academy of Microbiology (1994); American Academy of Arts and Sciences (1994); Associate (Foreign) Member, European Molecular Biology Organization (1999); Excellence in Mentoring Award,Association of Immunologists (2003); American Association of Cancer Research B.H.A. Clowes Award (2004); Rabi Shai Shacknai Memorial Prize in Immunology & Cancer Research (2005); Leukemia & Lymphoma Society de Villiers International Achievement Award (2005), Pasarow Foundation Prize in Cancer Research (2005); Irvington Institute Scientific Leadership in Immunology Award (2005); Establishment of Frederick W. Alt Award for New Discoveries in Immunology by the Irvington Institute (2006); National Cancer Institute Alfred Knudson Award in Cancer Genetics(2007). Dario Altieri Wistar Institute Cancer Center, Philadelphia, PA

Dario Altieri, MD, Robert and Penny Fox Distinguished Professor, Director, The Wistar Institute Cancer Center, Executive Vice President, Chief Scientific Officer, The Wistar Institute, Philadelphia, PA. Dafna Bar-Sagi NYU School of Medicine, New York, NY

Dafna Bar-Sagi, Ph.D., Professor and Chair, Department of Biochemistry New York University School of Medicine, 550 First Avenue New York, NY 10016 After earning her undergraduate and master's degree in Biochemistry from Bar-Ilan University in Israel, Dr. Bar-Sagi completed a PhD in Cell Biology at the State University of New York, Stony Brook (SUNY). She received postdoctoral training and eventually served as Senior Staff Investigator at Cold Spring Harbor Laboratory in Long Island. In 1995, she joined the faculty of the Department of Molecular Genetics and Microbiology at SUNY and served as Department Chair from 2003-2006. She relocated to New York University Medical Center in 2006, where she is currently Professor and Chair of the Department of Biochemistry. Dr. Bar-Sagi has published over 100 peer-reviewed articles in leading scientific journals. In 2008, she was appointed Chair of the Scientific Advisory Board of the Pancreatic Cancer Action Network. Jiri Bartek Institute of Cancer Biology, Copenhagen, Denmark

Jiri Bartek, MD., Ph.D., Professor, Head, Department of Cell Cycle and Cancer Danish Cancer Society, Deputy Director, Centre for Genotoxic Stress Research Cancer Institute of Cancer Biology, Copenhagen He received his M.D. degree from Palacky University in Olomouc, and his Ph.D. degree in Cell Biology from the Institute of Molecular Genetics in Prague, Czech Republic. His main research interests include the molecular mechanisms of mammalian cell-cycle control and responses to DNA damage, and the cancer-predisposing aberrations of these regulatory pathways. Jiri Bartek has a total of more than 320 publications in peer reviewed journals (about 30-40 in Nature, Science and Cell), with over 26.000 citations. He is currently member of the editorial boards of 10 high-medium impact biomedical journals and has won a number of awards including: (1991,1992) Czech Medical Association Award, (2000) Elected EMBO member, (2002) A. Benzon Prize, (2003) Novo Nordisk Prize, (2003) G.J. Mendel Medal, (2006) Danish Cancer Society Prize Stephen Baylin Johns Hopkins University, Baltimore, MD

Stephen B. Baylin, M.D., Professor, Deputy Director, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Virginia and DK Ludwig Professor of Oncology, Baltimore, MD, USA Dr. Stephen B. Baylin is professor of oncology and medicine, director of the cancer biology program at the oncology center, and the Virginia and D.K. Ludwig Professor of Cancer Research at The Johns Hopkins University School of Medicine, and the associate director for research at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Dr. Baylin has been a member of committees of the American Cancer Society and the National Institutes of Health, and his multiple honors include a Research Career Development Award from the National Institutes of Health. For the last 20 years, Dr. Baylin has studied the role of epigenetic gene silencing in the initiation and progression of human cancer.

https://doi.org/10.18632/oncotarget.17012

Joseph R. Bertino

Lingyan Zhu, Gongxian Wang, Shane Fischbach, and Xiangwei Xiao

Cancer Institute of New Jersey, New Brunswick, NJ

52294-52303 Abstract | PDF | HTML | Order a Reprint Detection of BRAF, NRAS, KIT, GNAQ, GNA11 and MAP2K1/2 mutations in Russian melanoma patients using LNA PCR clamp and biochip analysis https://doi.org/10.18632/oncotarget.17014 Marina Emelyanova, Lilit Ghukasyan, Ivan Abramov, Oxana Ryabaya, Evgenia Stepanova, Anna Kudryavtseva, Asiya Sadritdinova, Cholpon Dzhumakova, Tatiana Belysheva, Sergey Surzhikov, Lyudmila Lyubchenko, Alexander Zasedatelev, and Tatiana Nasedkina

52304-52320 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Oncogenic secretory clusterin in hepatocellular carcinoma: Expression at early staging and emerging molecular target https://doi.org/10.18632/oncotarget.13674 Wenjie Zheng, Min Yao, Qi Qian, Wenli Sai, Liwei Qiu, Junling Yang, Wei Wu, Zhizhen Dong, and Dengfu Yao

52321-52332 Abstract | PDF | HTML | Order a Reprint Positive regulation of TAZ expression by EBV-LMP1 contributes to cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma https://doi.org/10.18632/oncotarget.13775 Jiang He, Feiyu Tang, Liyu Liu, Lin Chen, Jiang Li, Danming Ou, Lu Zhang, Zhi Li, Deyun Feng, Wenzheng Li, and Lun-Quan Sun

52333-52344 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor https://doi.org/10.18632/oncotarget.17017 Jeewon Kim, June Ho Shin, Che-Hong Chen, Leslie Cruz, Lovisa Farnebo, Jieying Yang, Paula Borges, Gugene Kang, Daria Mochly-Rosen, and John B. Sunwoo

52345-52356 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma https://doi.org/10.18632/oncotarget.14096 Hongyuan Jiang, Xiao Zhang, Yuquan Tao, Liang Shan, Qijun Jiang, Yongchun Yu, Feng Cai, and Lifang Ma

52357-52365 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Comparisons of short-term and survival outcomes of laparoscopy-assisted versus open total gastrectomy for gastric cancer patients https://doi.org/10.18632/oncotarget.17019 Xin-Zu Chen, Shao-Yong Wang, Yin-Su Wang, Zi-Han Jiang, Wei-Han Zhang, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Meng Qiu, Hong-Feng Gou, Zong-Guang Zhou, and Jian-Kun Hu

52366-52380 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice https://doi.org/10.18632/oncotarget.14154 Andrew K. Kwegyir-Afful, Francis N. Murigi, Puranik Purushottamachar, Vidya P. Ramamurthy, Marlena S. Martin, and Vincent C.O. Njar

52381-52402 Abstract | PDF | HTML | Order a Reprint Expression analysis of microRNA as prognostic biomarkers in colorectal cancer https://doi.org/10.18632/oncotarget.14175 Jie Yang, Dongling Ma, Andrew Fesler, Haiyan Zhai, Apisri Leamniramit, Wenzhe Li, Song Wu, and Jingfang Ju

52403-52412 Abstract | PDF | HTML | Order a Reprint A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors https://doi.org/10.18632/oncotarget.14183 Adam L. Cohen, Abhijit Ray, Matthew Van Brocklin, David M. Burnett, Randy C. Bowen, Donna L. Dyess, Thomas W. Butler, Theresa Dumlao, and Hung T. Khong

52413-52419 Abstract | PDF | HTML | Order a Reprint Unit resection of buccal squamous cell carcinoma: Description of a new surgical technique https://doi.org/10.18632/oncotarget.14191 Zhen-Hu Ren, Zhao-Jian Gong, and Han-Jiang Wu

52420-52431 Abstract | PDF | HTML | Order a Reprint CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression https://doi.org/10.18632/oncotarget.14194 Shuiliang Yu, Neetha Parameswaran, Ming Li, Yiwei Wang, Mark W. Jackson, Huiping Liu, Wei Xin, and Lan Zhou

52432-52444 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Eribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines https://doi.org/10.18632/oncotarget.17190 Lilly Magdalena Weiß, Manuela Hugle, and Simone Fulda

52445-52456 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Prognostic role of podocalyxin-like protein expression in various cancers: A systematic review and meta-analysis https://doi.org/10.18632/oncotarget.14199 Jing Wang, Yongzhao Zhao, Ruizhao Qi, Xiaoning Zhu, Chenshen Huang, Sijin Cheng, Shengzhi Wang, and Xiaolong Qi

52457-52464 Abstract | PDF | HTML | Supplementary Information | Order a Reprint MiR-199a-3p suppresses proliferation and invasion of prostate cancer cells by targeting Smad1 https://doi.org/10.18632/oncotarget.17191 Feng Qu, Jinyu Zheng, Weidong Gan, Huibo Lian, Hua He, Wuping Li, Tian Yuan, Yaling Yang, Xiaogong Li, Changwei Ji, Xiang Yan, Linfeng Xu, and Hongqian Guo

52465-52473 Abstract | PDF | HTML | Order a Reprint Whole tumor RNA-sequencing and deconvolution reveal a clinicallyprognostic PTEN/PI3K-regulated glioma transcriptional signature https://doi.org/10.18632/oncotarget.17193 Yuan Pan, Erin C. Bush, Joseph A. Toonen, Yu Ma, Anne C. Solga, Peter A. Sims, and David H. Gutmann

52474-52487 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Prostate-derived ETS factor improves prognosis and represses proliferation and invasion in hepatocellular carcinoma https://doi.org/10.18632/oncotarget.14924 Er-Bao Chen, Shao-Lai Zhou, Xu-Guang Pang, Dan Yin, Pei-Zhen Miao, Yi Yang, Qing Chen, Kai Zhu, Dong-Mei Gao, Tian-Shu Liu, Xiao-Yi Wang, Ying-Hong Shi, Wei-Zhong Wu, Jian Zhou, Zheng-Jun Zhou, and Zhi Dai

52488-52500 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Excessive matrix metalloprotease-mediated degradation of interstitial tissue (type I collagen) independently predicts short-term survival in an observational study of postmenopausal women diagnosed with cancer https://doi.org/10.18632/oncotarget.15275 Nicholas Willumsen, Cecilie L. Bager, Stephanie N. Kehlet, Katrine Dragsbaek, Jesper S. Neergaard, Henrik B. Hansen, Anne-Christine Bay-Jensen, Diana J. Leeming, Allan Lipton, Claus Christiansen, and Morten Karsdal

Joseph R. Bertino, M.D., Professor of Medicine and Pharmacology, The Cancer Institute of New Jersey, UMDNJRobert Wood Johnson Medical School He has been an American Cancer Society professor since 1976. From 1973 to 1986, Dr. Bertino served as director of the Yale Comprehensive Cancer Center, including director of the center and associate director for clinical research. Dr. Bertino has been internationally recognized for his role in finding curative treatments for leukemia and lymphoma. Dr.Bertino has received several awards and honors, including the Rosenthal Award from the American Association of Clinical Research, the Karnofsky Award from the American Society for Clinical Oncology, and the American Cancer Society Medal of Honor. He was the founding editor of the Journal of Clinical Oncology. Currently, he is the associate editor for Cancer Research and Clinical Cancer Research and also the editor of the Encyclopedia of Cancer. Dr. Bertino served as president for the American Society of Clinical Oncology in 1976, and president of the American Association for Cancer Research in 1995-96. Dr. Bertino is the author and co-author of more than 400 scientific publications. Mina J. Bissell Lawrence Berkeley National Laboratory, Berkeley, CA

Mina J. Bissell, PhD, member of the National Academy of Sciences, Distinguished Scientist, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkley, CA Mina Bissell has been recognized for her lifetime contributions to the fields of breast cancer research, the enhanced role of extracellular matrix (ECM) and the nucleus environment to gene expression in normal and malignant tissues. These works have ushered and have changed some central paradigms that have strengthened the importance of context in the development of cancer. Bruce Blazar University of Minnesota, Minneapolis MN

Bruce R. Blazar, M.D., Professor, University of Minnesota, Minneapolis MN Bruce R. Blazar is a Regents Professor of Pediatrics, and Chief of the Pediatric Blood and Marrow Transplantation Program. Dr. Blazar is the Director of the University of Minnesota's Clinical and Translational Science Institute. Kenneth Cowan University of Nebraska Medical Center, Omaha, NE

Kenneth Cowan, M.D., Ph.D., Professor, University of Nebraska Medical Center, Omaha, NE, Director, Eppley Institute, Director, UNMC Eppley Cancer Center. Dr. Cowan has authored more than 240 papers for scientific journals and has been appointed by President Bush to a six-year term on the National Cancer Advisory Board to help shape cancer policy. Carlo M. Croce The Ohio State University, Columbus, OH

Carlo M. Croce, MD, Professor, member of the National Academy of Sciences, Director of Comprehensive Cancer Center, Chair, Molecular Virology, Immunology & Medical Genetics, The Ohio State University, Columbus, OH Chi Van Dang Johns Hopkins University, Baltimore, MD

Chi Van Dang, M.D., Ph.D. Professor, Vice Dean for Research, the Johns Hopkins University School of Medicine, Baltimore, MD Dr. Dang has written more than 200 scientific papers. He is senior editor of Cancer Research and serves on the editorial boards of eight other scientific publications, including the Journal of Molecular Medicine, Current Cancer Therapy Reviews, Drug Discovery Today: Disease Mechanisms, Journal of Clinical Investigations, Neoplasia, Clinical and Translational Science and The Vietnamese Medical Journal. Elected to the National Academy of Sciences' Institute of Medicine in 2006, Dr. Dang has received the National Institutes of Health/National Cancer Institute MERIT award and numerous other accolades. Ronald A. DePinho The University of Texas MD Anderson Cancer Center

Ronald A. DePinho, President, The University of Texas MD Anderson Cancer Center, MD, Professor of Medicine, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA His recent Awards includes Albert SzentGyrgyi Prize for Progress in Cancer Research, 2009; Helsinki Medal, 2007; Albert Einstein College of Medicine Distinguished Alumnus Award, 2004; American Cancer Society Edith A. Pistorino Research Professorship, 2004; Member, Institute of Medicine of the National Academies, 2004; AACR-G.H.A. Clowes Memorial Award, 2003 Brian J. Druker Oregon Health Science Univ., Portland, OR

Brian J. Druker, MD, PhD, member of the National Academy of Sciences, Professor, Oregon Health & Science University, Director, OHSU Knight Cancer Institute, Oregon Health & Science University Dr. Druker is the director of OHSU Knight Cancer Institute, JELD-WEN Chair of Leukemia Research, and professor of medicine. In 2009 he won the Lasker Clinical Award and the Meyenburg Cancer Research Prize for his influential work in the development of STI571, commonly known as Gleevec, for the treatment of Chronic Myeloid Leukemia. Dr. Druker is an investigator of Howard Hughes Medical Institute (HHMI), and was elected to the Institute of Medicine of National Academies in 2003, the American Association of Physician in 2006, and the National Academy of Sciences in 2007.

52501-52510

Wafik S. El-Deiry

Abstract | PDF | HTML | Order a Reprint

Penn State Hershey Cancer Institute, Hershey, PA

Api5 a new cofactor of estrogen receptor alpha involved in breast cancer outcome https://doi.org/10.18632/oncotarget.17281 Céline Basset, Florence Bonnet-Magnaval, Marina Garcia-Jove Navarro, Christian Touriol, Monique Courtade, Hervé Prats, Barbara Garmy-Susini, and Eric Lacazette

52511-52526 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Effects of microRNA-126 on cell proliferation, apoptosis and tumor angiogenesis via the down-regulating ERK signaling pathway by targeting EGFL7 in hepatocellular carcinoma https://doi.org/10.18632/oncotarget.17283 Cheng Gong, Jing Fang, Guang Li, Han-Han Liu, and Zhi-Su Liu

52527-52542 Abstract | PDF | HTML | Order a Reprint New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis https://doi.org/10.18632/oncotarget.15002 Alexandre Plessier, Ludivine LeDret, Pascale Varlet, Kevin Beccaria, Joelle Lacombe, Sebastien Meriaux, Francoise Geffroy, Laurence Fiette, Patricia Flamant, Fabrice Chretien, Thomas Blauwblomme, Stephanie Puget, Jacques Grill, Marie-Anne Debily, and David Castel

52543-52559 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Hepatitis B virus surface proteins accelerate cholestatic injury and tumor progression in Abcb4-knockout mice https://doi.org/10.18632/oncotarget.15003 Daniel Zahner, Hannah Glimm, Tomomitsu Matono, Yuri Churin, Diran Herebian, Ertan Mayatepek, Kernt Köhler, Stefan Gattenlöhner, Anne Stinn, Annette Tschuschner, Martin Roderfeld, and Elke Roeb

52560-52570 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Integrated expression profiles analysis reveals novel predictive biomarker in pancreatic ductal adenocarcinoma https://doi.org/10.18632/oncotarget.16732 Hongzhe Li, Xinjing Wang, Yuan Fang, Zhen Huo, Xiongxiong Lu, Xi Zhan, Xiaxin Deng, Chenghong Peng, and Baiyong Shen

52571-52583 Abstract | PDF | HTML | Supplementary Information | Order a Reprint siRNA-mediated inactivation of HER3 improves the antitumour activity and sensitivity of gefitinib in gastric cancer cells https://doi.org/10.18632/oncotarget.17526 Heng-Heng Yuan, Ying-Nan Yang, Jian-Hua Zhou, Yan-Jing Li, Li-Ying Wang, Jun-Wei Qin, Tao Liu, Zhen-Zhen Li, Qing-Xin Zhou, Xiao-Li Wei, Ting-Ting Zhang, Peng Huang, Wen-Jie Zhang, Lei Liu, Xiao-Xue Du, and Yu Han

52584-52593 Abstract | PDF | HTML | Order a Reprint Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction https://doi.org/10.18632/oncotarget.17529 Pengfei Hu, Tao Dai, Weiwei Yu, Ying Luo, and Shuwei Huang

52594-52603 Abstract | PDF | HTML | Order a Reprint Identification of long non-coding RNAs biomarkers associated with progression of endometrial carcinoma and patient outcomes https://doi.org/10.18632/oncotarget.17537 Yanan Sun, Xiaoyan Zou, Jun He, and Yuqin Mao

52604-52613 Abstract | PDF | HTML | Supplementary Information | Order a Reprint MM-BMSCs induce naïve CD4+ T lymphocytes dysfunction through fibroblast activation protein https://doi.org/10.18632/oncotarget.17538 Xiaofei Wu, Yadan Wang, Jian Xu, Ting Luo, Jun Deng, and Yu Hu

52614-52628 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens https://doi.org/10.18632/oncotarget.17539 Zhe Xu, Xi Jin, Tingru Pan, Tianqi Liu, Na Wan, and Shu Li

52629-52641 Abstract | PDF | HTML | Order a Reprint Suppression of pyruvate dehydrogenase kinase-2 re-sensitizes paclitaxelresistant human lung cancer cells to paclitaxel https://doi.org/10.18632/oncotarget.16991 Hong Sun, Anyou Zhu, Xiang Zhou, and Fengchao Wang

52642-52650 Abstract | PDF | HTML | Order a Reprint Combination treatment with transarterial chemoembolization, radiotherapy, and hyperthermia (CERT) for hepatocellular carcinoma with portal vein tumor thrombosis: Final results of a prospective phase II trial https://doi.org/10.18632/oncotarget.17072 Jeong Il Yu, Hee Chul Park, Sang Hoon Jung, Changhoon Choi, Sung Wook Shin, Sung Ki Cho, Dong Hyun Sinn, Yong-Han Paik, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Byung Chul Yoo, Hüseyin Sahinbas, and Seung Woon Paik

52651-52664 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Prognostic value of Flotillin-1 expression in patients with solid tumors https://doi.org/10.18632/oncotarget.17075 Yang-Xi Ou, Fang-Teng Liu, Fang-Ying Chen, and Zheng-Ming Zhu

52665-52677 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3+ regulatory T cells https://doi.org/10.18632/oncotarget.17079 Maik Luu, Elena Jenike, Niyati Vachharajani, and Alexander Visekruna

52678-52689 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Erectile dysfunction and the risk of prostate cancer https://doi.org/10.18632/oncotarget.17082 Wei-Yu Lin, Ying-Hsu Chang, Cheng-Li Lin, Chia-Hung Kao, and Hsi-Chin Wu

52690-52698 Abstract | PDF | HTML | Order a Reprint TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion https://doi.org/10.18632/oncotarget.17084 Yan Lv, Meng Si, Nannan Chen, Ya Li, Xingkai Ma, Huijun Yang, Ling Zhang, Hongyan Zhu, Guang-yin Xu, Ge-ping Wu, and C. Cao

52699-52707 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Detection of nasopharyngeal carcinoma susceptibility with single nucleotide polymorphism analysis using next-generation sequencing technology https://doi.org/10.18632/oncotarget.17085 Mu-Yun Wu, Shu-Jing Huang, Fan Yang, Xin-Tian Qin, Ying Ding, Shu Yang, and Xi-Cheng Wang

52708-52723 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Mitral isthmus ablation using a circular mapping catheter positioned in the left atrial appendage as a reference for conduction block https://doi.org/10.18632/oncotarget.17092 Takahiko Nishiyama, Takehiro Kimura, Taishi Fujisawa, Kazuaki Nakajima, Akira Kunitomi, Shin Kashimura, Yoshinori Katsumata, Nobuhiro Nishiyama, Yoshiyasu Aizawa, Keiichi Fukuda, and Seiji Takatsuki

52724-52734 Abstract | PDF | HTML | Order a Reprint NFATc3 mediates the sensitivity of gastric cancer cells to arsenic sulfide https://doi.org/10.18632/oncotarget.17175 Xiuli Zhang, Ting Kang, Lian Zhang, Yingying Tong, Wenping Ding, and Siyu Chen

52735-52745 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Transgenic overexpression of NanogP8 in the mouse prostate is insufficient to initiate tumorigenesis but weakly promotes tumor development in the Hi-Myc mouse model https://doi.org/10.18632/oncotarget.17186 Bigang Liu, Shuai Gong, Qiuhui Li, Xin Chen, John Moore, Mahipal V. Suraneni, Mark D. Badeaux, Collene R. Jeter, Jianjun Shen, Rashid Mehmood, Qingxia Fan, and Dean G. Tang

52746-52760 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Downregulated long noncoding RNA ALDBGALG0000005049 induces inflammation in chicken muscle suffered from selenium deficiency by regulating stearoyl-CoA desaturase https://doi.org/10.18632/oncotarget.17187 Ruifeng Fan, Changyu Cao, Xia Zhao, Qunxiang Shi, Jinxin Zhao, and Shiwen Xu

52761-52774 Abstract | PDF | HTML | Supplementary Information | Order a Reprint

Middle-distance running acutely influences the concentration and composition of serum bile acids: Potential implications for cancer risk? https://doi.org/10.18632/oncotarget.17188 Elisa Danese, Gian Luca Salvagno, Cantor Tarperi, Davide Negrini, Martina Montagnana, Luca Festa, Fabian Sanchis-Gomar, Federico Schena, and Giuseppe Lippi

52775-52782 Abstract | PDF | HTML | Order a Reprint Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells https://doi.org/10.18632/oncotarget.17189 Yong-Hao Huang, Yan Sun, Feng-Ying Huang, Yue-Nan Li, Cai-Chun Wang, Wen-Li Mei, HaoFu Dai, Guang-Hong Tan, and Canhua Huang

52783-52791 Abstract | PDF | HTML | Order a Reprint Prediction of EGFR and KRAS mutation in non-small cell lung cancer using quantitative 18F FDG-PET/CT metrics https://doi.org/10.18632/oncotarget.17782 Ryogo Minamimoto, Mehran Jamali, Olivier Gevaert, Sebastian Echegaray, Amanda Khuong, Chuong D. Hoang, Joseph B. Shrager, Sylvia K. Plevritis, Daniel L. Rubin, Ann N. Leung, Sandy Napel, and Andrew Quon

52792-52801 Abstract | PDF | HTML | Order a Reprint High-resolution dynamic imaging and quantitative analysis of lung cancer xenografts in nude mice using clinical PET/CT https://doi.org/10.18632/oncotarget.17263 Ying Yi Wang, Kai Wang, Zuo Yu Xu, Yan Song, Chu Nan Wang, Chong Qing Zhang, Xi Lin Sun, and Bao Zhong Shen

52802-52812 Abstract | PDF | HTML | Order a Reprint Apatinib inhibits VEGFR-2 and angiogenesis in an in vivo murine model of nasopharyngeal carcinoma https://doi.org/10.18632/oncotarget.17264 Qiu-Xia Peng, Yun-Wei Han, Yan-Ling Zhang, Jie Hu, Juan Fan, Shao-Zhi Fu, Shan Xu, and Qiang Wan

52813-52822 Abstract | PDF | HTML | Order a Reprint Chromatin remodeling modulates radiosensitivity of the daughter cells derived from cell population exposed to low- and high-LET irradiation https://doi.org/10.18632/oncotarget.17275 Ping Wang, Dexiao Yuan, Fei Guo, Xiaoyan Chen, Lin Zhu, Hang Zhang, Chen Wang, and Chunlin Shao

52823-52836 Abstract | PDF | HTML | Order a Reprint Uridine diphosphate-glucuronosyltransferase 2B15 D85Y gene polymorphism is associated with lower prostate cancer risk: a systematic review and meta-analysis https://doi.org/10.18632/oncotarget.17375 Xiao Zhong, Jiayu Feng, Ya Xiao, Pingxian Wang, Qiming Fan, Ronghua Wu, Wengang Hu, and Chibing Huang

52837-52845 Abstract | PDF | HTML | Order a Reprint Changing trends in the prevalence of anencephaly in Liaoning province of Northeast China from 2006–2015: data from a population-based birth defects registry https://doi.org/10.18632/oncotarget.17423 Ting-Ting Gong, Qi-Jun Wu, Yan-Ling Chen, Cheng-Zhi Jiang, Da Li, Jing Li, Li-Li Li, Chen Zhou, and Yan-Hong Huang

52846-52853 Abstract | PDF | HTML | Order a Reprint OVA12 promotes tumor growth by regulating p53 expression in human cancer cells https://doi.org/10.18632/oncotarget.17501 Renfeng Zhang, Xicai Wu, Xiangfeng Xia, Asma Khanniche, Feifei Song, Bingchang Zhang, Ying Wang, and Hailiang Ge

52854-52865 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Treatment of hepatocellular carcinoma with a GPC3-targeted bispecific T cell engager https://doi.org/10.18632/oncotarget.17905 Yanyu Bi, Hua Jiang, Peng Wang, Bo Song, Huamao Wang, Xianming Kong, and Zonghai Li

52866-52876 Abstract | PDF | HTML | Supplementary Information | Order a Reprint The anti-ErbB2 antibody H2-18 and the pan-PI3K inhibitor GDC-0941 effectively inhibit trastuzumab-resistant ErbB2-overexpressing breast cancer https://doi.org/10.18632/oncotarget.17907 Lingfei Wang, Xiaojie Yu, Chao Wang, Shujun Pan, Beibei Liang, Yajun Zhang, Xiaodan Chong, Yanchun Meng, Jian Dong, Yirong Zhao, Yang Yang, Huajing Wang, Jie Gao, Huafeng Wei, Jian Zhao, Hao Wang, Chaohua Hu, Wenze Xiao, and Bohua Li

52877-52888 Abstract | PDF | HTML | Supplementary Information | Order a Reprint PD-L1: a novel prognostic biomarker in head and neck squamous cell carcinoma https://doi.org/10.18632/oncotarget.17547 Tim Müller, Martin Braun, Dimo Dietrich, Seher Aktekin, Simon Höft, Glen Kristiansen, Friederike Göke, Andreas Schröck, Johannes Brägelmann, Stefanie A.E. Held, Friedrich Bootz, and Peter Brossart

52889-52900 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Twist1 confers multidrug resistance in colon cancer through upregulation of ATP-binding cassette transporters

Wafik S. El-Deiry, M.D., Ph.D. Professor of Medicine, Chief, Hematology/Oncology Rose Dunlap Division Chair in Hematology/Oncology, Associate Director for Translational Research, Cancer Institute, Penn State Hershey Cancer Institute, Hershey, PA Wafik S. El-Deiry is also an American Cancer Society Research Professor, the Rose Dunlap Professor of Medicine. He is among the top most-cited researchers. His paper, "WAF1, a potential mediator of P53 tumor suppression" (Cell, 75[4]: 81725, 19 November 1993) is among the top 10 most-cited papers of the 1990s. He is Editor-in-Chief of Cancer Biology and Therapy Michael A. Dyer St. Jude Children's Research Hospital, Memphis, TN

Michael A. Dyer, PhD, Professor/Member, St. Jude Faculty CoLeader, Developmental Therapeutics for Solid Malignancies Program Andrew Feinberg Johns Hopkins University School of Medicine, Baltimore, MD

Andrew Feinberg, MD, MPH, King Fahd Professor of Molecular Medicine Department of Medicine, Department of Oncology and Department of Molecular Biology & Genetics, Johns Hopkins University School of Medicine Dean W. Felsher Stanford University School of Medicine, Stanford, CA

Dean W. Felsher, MD, PhD, Stanford University School of Medicine, Stanford, CA Antonio Giordano Temple University, Philadelphia, PA

Antonio Giordano, MD, Ph.D, Professor and Director, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA He has published over 350 papers on his work in the fields of cell cycle, gene therapy and the genetics of cancer. Giordano has been named a Knight of the Republic of Italy for outstanding achievements in cancer research. In September of 2009, Giordano received the Philip Mazzei "The Bridge" Award from The American University of Rome for his scientific and economic contributions to the United States and Italy. In the past three years, Dr. Giordano's work has been profiled in Philadelphia Magazine, Philadelphia Business Journal, and Science. Candace S Johnson Roswell Park Cancer Institute, Buffalo, NY

President & CEO of Roswell Park Cancer Institute, the Wallace Family Chair in Translational Research, and Professor of Oncology. William G. Kaelin, Jr. Dana-Farber Cancer Institute, Harvard Univ. Boston, MA

William G. Kaelin Jr., MD, member of the National Academy of Sciences, Professor of Medicine, Harvard Medical School Dr. Kaelin is a 2010 Canada Gairdner International Award Recipient. He is a Howard Hughes Medical Investigator since 1998, a member of the American Society of Clinical Investigation and the American College of Physicians. He recently served on the National Cancer Institute Board of Scientific Advisors, the AACR Board of Trustees, and the Institute of Medicine National Cancer Policy Board. He is a recipient of the Paul Marks Prize for cancer research from the Memorial Sloan-Kettering Cancer Center, the Richard and Hinda Rosenthal Prize from the AACR, and a Doris Duke Distinguished Clinical Scientist award. In 2007 he was elected to the Institute of Medicine and in 2010 he was elected to the National Academy of Sciences. Michael Karin University of California, Los Angeles, CA

Michael Karin, Ph.D, member of the National Academy of Sciences, Professor of Pharmacology at the University of California, San Diego (UCSD; La Jolla, CA) Dr. Karin has received numerous awards including the Oppenheimer Award for Excellence in Research from the Endocrine Society, The Herman Beerman Lectureship from the Society of Investigative Dermatology, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin, The Grossman Lectureship form the American Gastroenterology Association and an American Cancer Society Research Professorship in 1999. Dr. Karin was elected to the National Academy of Sciences in 2005. Dr. Karin also serves on several advisory boards and was cofounder of Signal Pharmaceuticals (currently Celgene). Scott E. Kern Johns Hopkins University, Baltimore, MD

Scott E. Kern, M.D., Professor of Oncology, Johns Hopkins University, Baltimore, MD, co-director of the Kimmel Cancer Center Gastrointestinal Cancer Program, Everett and Marjorie Kovler Professor of Pancreas Cancer Research. Dr. Kern is a molecular geneticist interested in the clonal mutations of cancer, especially pancreatic cancer. His laboratory identified the first human Smad gene, SMAD4, as well as the first cancer mutations in Smad4, BRCA2, and other genes. Current interests include pharmacogenomics, mitotic instability, and the clinical significance of cancer biomarkers. Guido Kroemer Research Director, INSERM, Paris, France

Guido Kroemer, Research Director, INSERM, Paris, France John S. Lazo UVA Cancer Center, Charlottesville, VA

John S. Lazo, PhD, Harrison Distinguished Professor, Departments of Pharmacology & Chemistry, Associate Director for Basic Science, UVA Cancer Center; Adjunct Professor Virginia Tech Carilion Research Institute Arnold Levine Institute for Advanced Study, Princeton, NJ

Arnold J. Levine, Ph.D. member of the National Academy, Professor, The Simons Center for Systems Biology in the School of Natural Sciences at the Institute for Advanced Study, Princeton, NJ. Levine was on the faculty of the Biochemistry Department of Princeton University from1968 to 1979, when he became chair and professor in the Department of Microbiology at the State University of New York, Stony Brook, School of Medicine. Returning to Princeton University in 1984, he was named Harry C. Wiess Professor in the Life Sciences in the Department of Molecular Biology, a position he held until 1998. He chaired the Department between 1984 and 1996. He was President and Chief Executive Officer of the Rockefeller University in New York City from 1998 to 2002, as well as Heilbrunn Professor of Cancer Biology and laboratory head until joining the Institute in 2002. The recipient of many honors including: the Medal for Outstanding Contributions to Biomedical Research from Memorial Sloan-Kettering Cancer Center (2000); the Keio Medical Science Prize of the Keio University Medical Science Fund, Japan (2000); the Albany Medical Center Prize in Medicine and Biomedical Research (2001); and the Award for Basic Research from the Surgical Society of Oncologists (2003). Levine is a member of the National Academy of Sciences and of the Academy's Institute of Medicine; he is also the author or coauthor of over 300 scientific papers, as well as a book, Viruses (1993). He has served as board member or adviser to numerous scientific organizations and educational institutions, among them the N.J. Biotechnology Institute, the American Cyanamid Corporation, the SUNY Health Sciences Center in Brooklyn, Albert Einstein College of Medicine, the Weizmann Institute, the Huntsman Cancer Center of the University of Utah, and the Institute for Cancer Research in Lausanne, Switzerland. Michael P. Lisanti University of Salford, Salford, UK

Professor Lisanti, M.D., Ph.D. serves as the Director of the Manchester Breakthrough Breast Cancer Research Unit and holds the Muriel Edith Rickman Chair of Breast Oncology within the Institute of Cancer Sciences. He is also Professor of Cancer Biology and the new founding Director of the Manchester Centre for Cellular Metabolism (MCCM). Gerry Melino University of Rome, Rome , Italy

Dr. Melino is Full Professor of Molecular Biology at the University of Rome “Tor Vergata” in Italy. He also currently works as Programme Leader for the Medical Research Council Toxicology Unit, in Leicester, UK. Harold L. Moses Vanderbilt-Ingram Cancer Center, Nashville, TN

Harold L. Moses, PhD, Professor, Vanderbilt-Ingram Cancer Center, Nashville, TN Yusuke Nakamura University of Chicago, IL

Dr. Nakamura received his MD and PhD from Osaka University, and became Head of the Biochemistry Department, at the Cancer Institute, Japanese Foundation for Cancer Research in 1989. He was appointed as a professor at the Institute of Medical Science, University of Tokyo in 1994 and the Department of Medicine at the University of Chicago in 2012. From January to December 2011, Dr. Nakamura was Special Advisor to the Cabinet Secretary General, Office of Medical Innovation, Cabinet Secretariat, Government of Japan. Dr. Nakamura received the Keio Medical Science Prize and the Tomizo Yoshida Award of the Japanese Cancer Association. He is a member of the Association of American Physicians. Dr. Yusuke Nakamura discovered the APC (Familial Adenomatous Polyposis) tumor suppressor. Dr. Nakamura plays the leading role in the field of personalized medicine. He authored 1200 scientific articles. Joseph Nevins Duke University, Durham, NC

Joseph Nevins, PhD, Professor, Duke University, Durham, NC Pier Paolo Pandolfi Harvard Medical School, Boston, MA

Pier Paolo Pandolfi, PhD, Professor, Harvard Medical School, Boston, MA Nickolas Papadopoulos, Johns Hopkins University, Baltimore, MD

Nickolas Papadopoulos, Ph.D. Associate Professor, Department of Oncology, Director of Translational Genetics, Ludwig Center for Cancer Genetics & Therapeutics, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Institutions, CRB1, Room 585, 1650 Orleans Street, Baltimore, MD 21231 Arthur B. Pardee Harvard University, Boston, MA

Arthur B. Pardee, Ph.D, member of the National Academy of Sciences, Professor of Biological Chemistry and Molecular Pharmacology Emeritus, Harvard Medical School Albert Einstein College of Medicine, Bronx, NY

Jeffrey Pollard, PhD, Professor, Albert Einstein College of Medicine, Bronx, NY

https://doi.org/10.18632/oncotarget.17548

Carol Prives

Yan-Rong Liu, Lan Liang, Jian Min Zhao, Yang Zhang, Min Zhang, Wei-Long Zhong, Qiang Zhang, Jun-Jie Wei, Meng Li, Jie Yuan, Shuang Chen, Shu-Min Zong, Hui-Juan Liu, Jing Meng, Yuan Qin, Bo Sun, Lan Yang, Hong-Gang Zhou, Tao Sun, and Cheng Yang

Columbia University, New York, NY

52901-52912 Abstract | PDF | HTML | Supplementary Information | Order a Reprint miR-106b regulates the 5-fluorouracil resistance by targeting Zbtb7a in cholangiocarcinoma https://doi.org/10.18632/oncotarget.17577 Dechao Jiao, Yan Yan, Shaofeng Shui, Gang Wu, JianZhuang Ren, Yanli Wang, and Xinwei Han

52913-52922 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury https://doi.org/10.18632/oncotarget.17629 Jian-Rong Guo, Huan Wang, Xiao-Ju Jin, Dong-Lin Jia, Xun Zhou, and Qiang Tao

52923-52934 Abstract | PDF | HTML | Order a Reprint Selective Inhibitors of Nuclear Export (SINE) compounds block proliferation and migration of triple negative breast cancer cells by restoring expression of ARRDC3 https://doi.org/10.18632/oncotarget.17987 Young Hwa Soung, Trinayan Kashyap, Thalia Nguyen, Garima Yadav, Hua Chang, Yosef Landesman, and Jun Chung

52935-52947 Abstract | PDF | HTML | Supplementary Information | Order a Reprint MiR-486-5p negatively regulates oncogenic NEK2 in hepatocellular carcinoma https://doi.org/10.18632/oncotarget.17635 Shun-Jun Fu, Jian Chen, Fei Ji, Wei-Qiang Ju, Qiang Zhao, Mao-Gen Chen, Zhi-Yong Guo, LinWei Wu, Yi Ma, Dong-Ping Wang, Xiao-Feng Zhu, and Xiao-Shun He

52948-52959 Abstract | PDF | HTML | Supplementary Information | Order a Reprint TUSC3 induces autophagy in human non-small cell lung cancer cells through Wnt/-catenin signaling https://doi.org/10.18632/oncotarget.17674 Yun Peng, Jun Cao, Xiao-Yi Yao, Jian-Xin Wang, Mei-Zuo Zhong, Ping-Ping Gan, and JianHuang Li

52960-52974 Abstract | PDF | HTML | Order a Reprint Mitochondrial DNA sequencing and large-scale genotyping identifies MTND4 gene mutation m.11696G>A associated with idiopathic oligoasthenospermia https://doi.org/10.18632/oncotarget.17675 Juan Ji, Miaofei Xu, Zhenyao Huang, Lei Li, Hongxiang Zheng, Shuping Yang, Shilin Li, Li Jin, Xiufeng Ling, Yankai Xia, Chuncheng Lu, and Xinru Wang

52975-52982 Abstract | PDF | HTML | Supplementary Information | Order a Reprint miR-133b down-regulates ABCC1 and enhances the sensitivity of CRC to anti-tumor drugs https://doi.org/10.18632/oncotarget.17677 Miao Chen, Daojiang Li, Ni Gong, Hao Wu, Chen Su, Canbin Xie, Hong Xiang, Changwei Lin, and Xiaorong Li

52983-52994 Abstract | PDF | HTML | Order a Reprint Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension https://doi.org/10.18632/oncotarget.18031 Aurélie Hautefort, Julie Chesné, Jens Preussner, Soni S. Pullamsetti, Jorg Tost, Mario Looso, Fabrice Antigny, Barbara Girerd, Marianne Riou, Saadia Eddahibi, Jean-François Deleuze, Werner Seeger, Elie Fadel, Gerald Simonneau, David Montani, Marc Humbert, and Frédéric Perros

52995-53016 Abstract | PDF | HTML | Order a Reprint MicroRNA profiles involved in trifluridine resistance https://doi.org/10.18632/oncotarget.18078 Kenta Tsunekuni, Masamitsu Konno, Ayumu Asai, Jun Koseki, Takashi Kobunai, Teiji Takechi, Yuichiro Doki, Masaki Mori, and Hideshi Ishii

53017-53027 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Dipeptidyl peptidase 4 inhibitor use is associated with a lower risk of incident acute kidney injury in patients with diabetes https://doi.org/10.18632/oncotarget.18081 Chia-Ter Chao, Jui Wang, Hon-Yen Wu, Kuo-Liong Chien, and Kuan-Yu Hung

53028-53040 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Long working hours, job satisfaction, and depressive symptoms: a community-based cross-sectional study among Japanese employees in small- and medium-scale businesses https://doi.org/10.18632/oncotarget.18084 Akinori Nakata

53041-53052 Abstract | PDF | HTML | Order a Reprint Lenalidomide increases human dendritic cell maturation in multiple myeloma patients targeting monocyte differentiation and modulating mesenchymal stromal cell inhibitory properties https://doi.org/10.18632/oncotarget.18085

Carol Prives, Ph.D, member of the National Academy of Sciences, Professor, Columbia University, New York, NY Edward V. Prochownik Children's Hospital of Pittsburgh, Pittsburgh, PA

Edward V. Prochownik, MD, PhD, Professor of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Director of Oncology Research, Children's Hospital of Pittsburgh, PA Neal Rosen, M.D., Ph.D. is a Member in the Department of Medicine and in the Molecular Pharmacology and Chemistry Program at Memorial Sloan-Kettering Cancer Center, where he serves as Head of Developmental Therapeutics. He is also a Professor of Pharmacology, Cell Biology and Medicine at Cornell University Medical School. John C. Reed Roche Holding AG, Basel, Switzerland

Dr. John C. Reed, M.D., Ph.D. has been the Head of Roche Pharma Research & Early Development (Pred) at Roche Holding AG since April 2, 2013. He is an Adjunct professor at the University of California San Diego (UCSD) Department of Molecular Pathology, University of Florida, University of Central Florida, and in San Diego State University's Biology department. Neal Rosen Sloan-Kettering Cancer Center, New York, NY

Neal Rosen, Sloan-Kettering Cancer Center, New York, NY Andrew V. Schally Veterans Affairs Medical Center Miami, FL

Andrew V. Schally won the Nobel Prize for Medicine or Physiology in 1977, for his research into peptide hormone production in the brain. He is currently Distinguished Medical Research Scientist of the Department of Veterans Affairs, Head of the Endocrine, Polypeptide and Cancer Institute Veterans Affairs Medical Center, Research Service Miami, FL and South Florida VA Foundation for Research and Education, Distinguished Leonard Miller Professor of Pathology, Professor Division of Hematology/Oncology and Division of Endocrinology Department of Medicine, Miller School of Medicine, University of Miami, FL. Dr. Schally was one of a pair of scientists to first isolate several of the communicating chemical links between the brain and the pituitary gland and also determined their structure and succeeded in synthesizing them. Schally’s discoveries have led to many practical clinical applications that are in wide use. He has written over 2,200 publications, more than 1,200 of them since receiving the Nobel Prize. 27 European & South American Universities: M.D.H.C., D.H.C., D.Sc.H.C., D.Nat. Sc. H.C. Lasker Award 1975 Nobel Prize in Physiology or Medicine, 1977 Gregg L. Semenza Johns Hopkins University, Baltimore, MD

Gregg L. Semenza, M.D., Ph.D, member of the National Academy of Sciences, Professor, Johns Hopkins University School of Medicine, Baltimore, MD Donald L. Trump Inova Schar Cancer Institute

Donald L. (Skip) Trump, MD, FACP, is CEO and executive director of Inova Schar Cancer Institute. Prior to joining Inova, Dr. Trump was president and CEO of Roswell Park Cancer Institute in Buffalo, NY. Alexander Varshavsky California Inst. of Technology, Pasadena, CA

Alexander Varshavsky, Ph.D, member of the National Academy of Sciences, Professor, California Institute of Technology, Pasadena, CA Alexander Varshavsky is a recipient of the Albert Lasker Award for Basic Medical Research, the Wolf Prize in Medicine and the Louisa Gross Horwitz Prize from Columbia University in 2001 for his research on ubiquitination. In 2006 he won the March of Dimes Prize in Developmental Biology and he won the 2007 $1 million Gotham Prize for an original approach to killing cancer cells.

Federica Costa, Rosanna Vescovini, Marina Bolzoni, Valentina Marchica, Paola Storti, Denise Toscani, Fabrizio Accardi, Laura Notarfranchi, Benedetta Dalla Palma, Cristina Manferdini, Sabrina Manni, Giannalisa Todaro, Gina Lisignoli, Francesco Piazza, Franco Aversa, and Nicola Giuliani

Bert Vogelstein

53053-53067

Johns Hopkins University, Baltimore, MD

Abstract | PDF | HTML | Supplementary Information | Order a Reprint Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN https://doi.org/10.18632/oncotarget.18087 Andrea Cavazzoni, Silvia La Monica, Roberta Alfieri, Andrea Ravelli, Nele Van Der Steen, Rocco Sciarrillo, Denise Madeddu, Costanza Anna Maria Lagrasta, Federico Quaini, Mara Bonelli, Claudia Fumarola, Daniele Cretella, Graziana Digiacomo, Marcello Tiseo, Godefridus J. Peters, Andrea Ardizzoni, Pier Giorgio Petronini, and Elisa Giovannetti

53068-53083 Abstract | PDF | HTML | Supplementary Information | Order a Reprint RNase alleviates neurological dysfunction in mice undergoing cardiac arrest and cardiopulmonary resuscitation https://doi.org/10.18632/oncotarget.18088 Ye Ma, Chan Chen, Shu Zhang, Qiao Wang, Hai Chen, Yuanlin Dong, Zheng Zhang, Yan Li, Zhendong Niu, Tao Zhu, Hai Yu, and Bin Liu

53084-53099 Abstract | PDF | HTML | Order a Reprint Discriminating patients with early-stage breast cancer from benign lesions by detection of oxidative DNA damage biomarker in urine https://doi.org/10.18632/oncotarget.17831 Cheng Guo, Xiaofen Li, Minfeng Ye, Fei Xu, Jiekai Yu, Cong Xie, Xiaoji Cao, Mengzhe Guo, Ying Yuan, and Shu Zheng

53100-53109 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Upregulation of long noncoding RNA HOXA-AS3 promotes tumor progression and predicts poor prognosis in glioma https://doi.org/10.18632/oncotarget.18162 Fan Wu, Chuanbao Zhang, Jinquan Cai, Fan Yang, Tingyu Liang, Xiaoyan Yan, Haoyuan Wang, Wen Wang, Jing Chen, and Tao Jiang

53110-53123 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Role of A-Kinase anchor protein (AKAP4) in growth and survival of ovarian cancer cells https://doi.org/10.18632/oncotarget.18163 Vikash Kumar, Nirmala Jagadish, and Anil Suri

53124-53136 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Prognostic values of tissue factor and its alternatively splice transcripts in human gastric cancer tissues https://doi.org/10.18632/oncotarget.17942 Min Wu, Lujun Chen, Ting Xu, Bin Xu, Jingting Jiang, and Changping Wu

53137-53145 Abstract | PDF | HTML | Order a Reprint Menstrual pattern after abdominal radical trachelectomy https://doi.org/10.18632/oncotarget.17943 Xiaoqi Li, Jin Li, Xingzhu Ju, Zhaoxia Jiang, Xiaojun Chen, and Xiaohua Wu

53146-53153 Abstract | PDF | HTML | Supplementary Information | Order a Reprint

A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer https://doi.org/10.18632/oncotarget.18587 Nicholas Villarino, Lia Signaevskaia, Jaco van Niekerk, Rachel Medal, Heejung Kim, Reyhaneh Lahmy, Kathleen Scully, Anthony Pinkerton, SangWun Kim, Andrew Lowy, and Pamela ItkinAnsari

53154-53167 Abstract | PDF | HTML | Supplementary Information | Order a Reprint MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides https://doi.org/10.18632/oncotarget.18230

Bert Vogelstein, M.D., member of the National Academy of Sciences, Professor, Johns Hopkins University, Baltimore, MD Bert Vogelstein is a Howard Hughes Medical Institute investigator. He has received the Gairdner Foundation International Award, Louisa Gross Horwitz Prize from Columbia University, Prince of Asturias Award for Technical and Scientific Research, and other awards for his research. Peter K. Vogt The Scripps Research Institute, La Jolla, CA

Peter K. Vogt, Ph.D, member of the National Academy of Sciences Professor, The Scripps Research Institute, La Jolla, CA Dr. Vogt is a Professor in the Department of Molecular and Experimental Medicine at The Scripps Research Institute in La Jolla, California. He has received many awards and honors, including the Gregor Johann Mendel Medal, Charles S. Mott Prize, Ernst Jung Prize for Medicine, Bristol Meyers Award, and ICN International Prize in Virology. Dr. Vogt has been invited as a distinguished lecturer by more than twenty leading research institutions in the US, Europe, and Asia, among them the German Cancer Research Center in Heidelberg for the Meyenburg Foundation Lecture, the Princess Takamatsu Foundation, the Alexander von Humboldt Foundation of the Federal Republic of Germany and the Agency for Science, Technology and Research of Singapore. He was also elected an Honorary Member of the Japanese Cancer Association and received an honorary doctorate from the University of Würzburg. Dr. Vogt is an elected member of many prestigious academies, including the American Academy of Arts and Sciences, the National Academy of Sciences, the Institute of Medicine of the National Academies, and the American Academy of Microbiology. He is the recipient of the 5th Annual Szent-Györgyi Prize for Progress in Cancer Research. Paul Workman The Institute of Cancer Research, London, UK

Paul Workman, The Institute of Cancer Research, London, UK Zeng Yixin Cancer Center and the State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China

Dr. Zeng Yixin, Professor and Director, Cancer Center and the State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China. He was elected as a member of the Chinese Academy of Sciences in 2005. Besides, Professor Zeng also has many other academic positions including the Vice President of the China Anti-Cancer Association, President of the Board of the International Society on Epstein-Barr Virus & Related Diseases (2006-2008), a member of the Third World Academy of Sciences, and a member of the EuropeAsian Academy of Sciences

See full editors list »

Young Mi Whang, Su Bin Jin, Serk In Park, and In Ho Chang

53168-53179 Abstract | PDF | HTML | Order a Reprint Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma https://doi.org/10.18632/oncotarget.18261 Tetsuya Idichi, Naohiko Seki, Hiroshi Kurahara, Keiichi Yonemori, Yusaku Osako, Takayuki Arai, Atsushi Okato, Yoshiaki Kita, Takaaki Arigami, Yuko Mataki, Yuko Kijima, Kosei Maemura, and Shoji Natsugoe

53180-53193 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Altered erythropoiesis and decreased number of erythrocytes in children with neuroblastoma https://doi.org/10.18632/oncotarget.18285 Fabio Morandi, Sebastiano Barco, Sara Stigliani, Michela Croce, Luca Persico, Corrado Lagazio, Francesca Scuderi, Maria Luisa Belli, Mariapina Montera, Giuliana Cangemi, Sarah Pozzi, Valentina Rigo, Paola Scaruffi, Loredana Amoroso, Giovanni Erminio, Vito Pistoia, Silvano Ferrini, and Maria Valeria Corrias

53194-53209 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Down regulation of human positive coactivator 4 suppress tumorigenesis and lung metastasis of osteosarcoma https://doi.org/10.18632/oncotarget.18290 Xu Hu, Chao Zhang, Ying Zhang, Christopher S. Hong, Wugui Chen, Weiwei Shen, Hongkai Wang, Jianrong He, Pei Chen, Yue Zhou, Chunmeng Shi, and Tongwei Chu

53210-53225 Abstract | PDF | HTML | Order a Reprint Increased p16 and p53 protein expression predicts poor prognosis in mucosal melanoma https://doi.org/10.18632/oncotarget.18367 Hanbin Chen, Yangyang Li, Yin Long, Erjiang Tang, Rongrong Wang, Kate Huang, Congying Xie, and Guorong Chen

53226-53233 Abstract | PDF | HTML | Order a Reprint Associations of high altitude polycythemia with polymorphisms in EPHA2 and AGT in Chinese Han and Tibetan populations https://doi.org/10.18632/oncotarget.18384 Lijun Liu, Yao Zhang, Zhiying Zhang, Yiduo Zhao, Xiaowei Fan, Lifeng Ma, Yuan Zhang, Haijin He, and Longli Kang

53234-53243 Abstract | PDF | HTML | Order a Reprint CXCL13 is androgen-responsive and involved in androgen induced prostate cancer cell migration and invasion https://doi.org/10.18632/oncotarget.18387 Long Fan, Qingyi Zhu, Li Liu, Cuicui Zhu, Haojie Huang, Shan Lu, and Ping Liu

53244-53261 Abstract | PDF | HTML | Order a Reprint Jagged-2 (JAG2) enhances tumorigenicity and chemoresistance of colorectal cancer cells https://doi.org/10.18632/oncotarget.18391 Vivek Vaish, Joohwee Kim, and Minsub Shim

53262-53275 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Infiltrating macrophages in diabetic nephropathy promote podocytes apoptosis via TNF--ROS-p38MAPK pathway https://doi.org/10.18632/oncotarget.18394 Yinfeng Guo, Zhixia Song, Min Zhou, Ying Yang, Yu Zhao, Bicheng Liu, and Xiaoliang Zhang

53276-53287 Abstract | PDF | HTML | Order a Reprint AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors https://doi.org/10.18632/oncotarget.18395 Renato José Silva-Oliveira, Matias Melendez, Olga Martinho, Maicon F. Zanon, Luciano de Souza Viana, André Lopes Carvalho, and Rui Manuel Reis

53288-53301 Abstract | PDF | HTML | Supplementary Information | Order a Reprint A combination of valproic acid sodium salt, CHIR99021, E-616452, tranylcypromine, and 3-Deazaneplanocin A causes stem cell-like characteristics in cancer cells https://doi.org/10.18632/oncotarget.18396 Shuang Sha, Yuanfen Zhai, Chengzhao Lin, Heyong Wang, Qing Chang, Shuang Song, Mingqiang Ren, and Gentao Liu

53302-53312 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Differential metabonomic profiles of primary hepatocellular carcinoma tumors from alcoholic liver disease, HBV-infected, and HCV-infected cirrhotic patients https://doi.org/10.18632/oncotarget.18397 Ding Cao, Can Cai, Mingxin Ye, Junhua Gong, Menghao Wang, Jinzheng Li, and Jianping Gong

53313-53325 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Diagnostic and prognostic values of cerebrospinal fluid CYFRA 21-1 in patients with leptomeningeal carcinomatosis https://doi.org/10.18632/oncotarget.18405 Jae-Won Hyun, Ji Hyun Park, Boo Gil Kang, Eun Young Park, Boram Park, Jungnam Joo, Jong Kuk Kim, Su-Hyun Kim, Jee Hyang Jeong, Hyang Woon Lee, Kee Duk Park, Kyung Gyu Choi, Sang-Hyun Hwang, Ho-Shin Gwak, and Ho Jin Kim

53326-53335 Abstract | PDF | HTML | Order a Reprint Clinicopathological characteristics of ROS1- and RET-rearranged NSCLC in caucasian patients: Data from a cohort of 713 non-squamous NSCLC lacking KRAS/EGFR/HER2/BRAF/PIK3CA/ALK alterations https://doi.org/10.18632/oncotarget.18408 Frédéric Dugay, Francisco Llamas-Gutierrez, Marjory Gournay, Sarah Medane, François Mazet, Dan Christian Chiforeanu, Emmanuelle Becker, Régine Lamy, Hervé Léna, Nathalie Rioux-Leclercq, Marc-Antoine Belaud-Rotureau, and Florian Cabillic

53336-53351 Abstract | PDF | HTML | Order a Reprint Autophagy-related genes are induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid via the activation of cathepsin B in human breast cancer cells https://doi.org/10.18632/oncotarget.18410 Han Han, Jing Li, Xiuyan Feng, Hui Zhou, Shanchun Guo, and Weiqiang Zhou

53352-53365 Abstract | PDF | HTML | Order a Reprint Dectin-1 signaling inhibits osteoclastogenesis via IL-33-induced inhibition of NFATc1 https://doi.org/10.18632/oncotarget.18411 Xiaoqing Zhu, Yinghua Zhao, Yuxue Jiang, Tianxue Qin, Jintong Chen, Xiao Chu, Qing Yi, Sujun Gao, and Siqing Wang

53366-53374 Abstract | PDF | HTML | Order a Reprint 20(S)-Rg3 blocked epithelial-mesenchymal transition through DNMT3A/miR145/FSCN1 in ovarian cancer https://doi.org/10.18632/oncotarget.18482 Jie Li, Jiaojiao Lu, Zhongxue Ye, Xi Han, Xia Zheng, Huilian Hou, Wei Chen, Xu Li, and Le Zhao

53375-53386 Abstract | PDF | HTML | Supplementary Information | Order a Reprint APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model https://doi.org/10.18632/oncotarget.18508 Guoguo Jin, Ke Yao, Zhiping Guo, Zhenjiang Zhao, Kangdong Liu, Fangfang Liu, Hanyong Chen, Dhilli Rao Gorja, Kanamata Reddy, Ann M. Bode, Ziming Dong, and Zigang Dong

53387-53404 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Brain metastases in patients with non-small cell lung cancer: the role of mutated-EGFRs with an exon 19 deletion or L858R point mutation in cancer cell dissemination https://doi.org/10.18632/oncotarget.18509 Shih-Hsin Hsiao, Yu-Ting Chou, Sey-En Lin, Ru-Chun Hsu, Chi-Li Chung, Yu-Rung Kao, H. Eugene Liu, and Cheng-Wen Wu

53405-53418 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Radial artery intima-media thickness regresses after secondary prevention interventions in patients’ post-acute coronary syndrome and is associated with cardiac and kidney biomarkers https://doi.org/10.18632/oncotarget.18511 Damilola D. Adingupu, Helena U. Westergren, Santosh Dahgam, Ann-Cathrine JönssonRylander, Juuso Blomster, Per Albertsson, Elmir Omerovic, Sara Svedlund, and Li-Ming Gan

53419-53431 Abstract | PDF | HTML | Order a Reprint An epigenetic signature of adhesion molecules predicts poor prognosis of ovarian cancer patients https://doi.org/10.18632/oncotarget.18515 Ping-Ying Chang, Yu-Ping Liao, Hui-Chen Wang, Yu-Chih Chen, Rui-Lan Huang, Yu-Chi Wang, Chiou-Chung Yuan, and Hung-Cheng Lai

53432-53449 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Hypertriglyceridemia in female rats during pregnancy induces obesity in male offspring via altering hypothalamic leptin signaling https://doi.org/10.18632/oncotarget.18519 Tanzil Ur Rahman, Kamran Ullah, Zhang-Hong Ke, Meng-Xi Guo, Lu-Yang Jin, Jun Ren, YuZhong Zhou, Yi Cheng, Xin-Yan Dong, Hai-Yan Pang, Ting-Ting Wang, Jian-Zhong Sheng, and He-Feng Huang

53450-53464 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Differential gene and lncRNA expression in the lower thoracic spinal cord following ischemia/reperfusion-induced acute kidney injury in rats https://doi.org/10.18632/oncotarget.18584 Qing-Quan Liu, Hui Liu, Zhi-Gang He, Shi-Jie Zhang, Bao-Wen Liu, Le Wang, Wen-Hui Qiu, Qing Xu, Hong-Bing Xiang, and Yong-Man Lv

53465-53481 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a NAFLD/NASH mouse model https://doi.org/10.18632/oncotarget.18585 Alessandra Tessitore, Valentina Mastroiaco, Antonella Vetuschi, Roberta Sferra, Simona Pompili, Germana Cicciarelli, Remo Barnabei, Daria Capece, Francesca Zazzeroni, Carlo Capalbo, and Edoardo Alesse

53482-53494 Abstract | PDF | HTML | Supplementary Information | Order a Reprint TLR4 interaction with LPS in glioma CD133+ cancer stem cells induces cell proliferation, resistance to chemotherapy and evasion from cytotoxic T lymphocyte-induced cytolysis https://doi.org/10.18632/oncotarget.18586 Fengyuan Che, Jiawei Yin, Yanchun Quan, Xiaoli Xie, Xueyuan Heng, Yifeng Du, and Lijuan Wang

53495-53507 Abstract | PDF | HTML | Order a Reprint Structural basis of mutant-selectivity and drug-resistance related to CO1686 https://doi.org/10.18632/oncotarget.18588 Xiao-E Yan, Su-Jie Zhu, Ling Liang, Peng Zhao, Hwan Geun Choi, and Cai-Hong Yun

53508-53517 Abstract | PDF | HTML | Order a Reprint SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells https://doi.org/10.18632/oncotarget.18591 Zhuqing Liu, Yu Zhao, Juemin Fang, Ran Cui, Yuanyuan Xiao, and Qing Xu

53518-53530 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Compliance with the enhanced recovery after surgery protocol and prognosis after colorectal cancer surgery: A prospective cohort study https://doi.org/10.18632/oncotarget.18602 Liang Li, Juying Jin, Su Min, Dan Liu, and Ling Liu

53531-53541 Abstract | PDF | HTML | Order a Reprint Value of quantitative magnetic resonance imaging T1-relaxometry in predicting contrast-enhancement in glioblastoma patients https://doi.org/10.18632/oncotarget.18612 Elke Hattingen, Andreas Müller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Ulrich Herrlinger, Martin Glas, and Sied Kebir

53542-53551 Abstract | PDF | HTML | Order a Reprint A vitamin D receptor agonist converts CD4+ T cells to Foxp3+ regulatory T cells in patients with ulcerative colitis https://doi.org/10.18632/oncotarget.18614 Dong Lu, Bin Lan, Zonren Din, Hang Chen, and Guoqiang Chen

53552-53562 Abstract | PDF | HTML | Order a Reprint The novel sphingosine-1-phosphate receptors antagonist AD2900 affects lymphocyte activation and inhibits T-cell entry into the lymph nodes https://doi.org/10.18632/oncotarget.18626 Jing Song, Arie Dagan, Zhanna Yakhtin, Shimon Gatt, Sean Riley, Hugh Rosen, Reuven Or, and Osnat Almogi-Hazan

53563-53580 Abstract | PDF | HTML | Supplementary Information | Order a Reprint lncRNA H19 mediates BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling https://doi.org/10.18632/oncotarget.18655 Junyi Liao, Xinyi Yu, Xue Hu, Jiaming Fan, Jing Wang, Zhicai Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Ruyi Zhang, Shujuan Yan, Yasha Li, Wenwen Zhang, Jing Cui, Chao Ma, Li Li, Yichun Yu, Tingting Wu, Xingye Wu, Jiayan Lei, Jia Wang, Chao Yang, Ke Wu, Ying Wu, Jun Tang, Bai-Cheng He, Zhong-Liang Deng, Hue H. Luu, Rex C. Haydon, Russell R. Reid, Michael J. Lee, Jennifer Moriatis Wolf, Wei Huang, and Tong-Chuan He

53581-53601 Abstract | PDF | HTML | Order a Reprint Selective ATP hydrolysis inhibition in F1Fo ATP synthase enhances radiosensitivity in non-small-cell lung cancer cells (A549) https://doi.org/10.18632/oncotarget.18657 Yupei Wang, Qinzheng Hou, Guoqing Xiao, Shifeng Yang, Cuixia Di, Jing Si, Rong Zhou, Yancheng Ye, Yanshan Zhang, and Hong Zhang

53602-53612 Abstract | PDF | HTML | Order a Reprint XPG gene rs751402 C>T polymorphism and cancer risk: Evidence from 22 publications https://doi.org/10.18632/oncotarget.19421 Haixia Zhou, Ting-Yan Shi, Wenwen Zhang, Qiwen Li, Jinhong Zhu, Jing He, and Jichen Ruan

53613-53622 Abstract | PDF | HTML | Order a Reprint

Meta-Analysis The prevalence of depression in rheumatoid arthritis in China: A systematic review https://doi.org/10.18632/oncotarget.17323 Xin Fu, Zhi-Jun Li, Chun-Jun Yang, Liangshu Feng, Lemeng Sun, Yang Yao, and Yu-Ting Huang

53623-53630 Abstract | PDF | HTML | Supplementary Information | Order a Reprint The impact of primary tumor location on efficacy of cetuximab in metastatic colorectal cancer patients with different Kras status: a systematic review and meta-analysis https://doi.org/10.18632/oncotarget.19022 De-Dong Cao, Hui-Lin Xu, Xi-Ming Xu, and Wei Ge

53631-53641 Abstract | PDF | HTML | Supplementary Information | Order a Reprint

Clinical Research Papers Prognostic value of molecular events from negative surgical margin of nonsmall-cell lung cancer https://doi.org/10.18632/oncotarget.10949 Bangrong Cao, Lin Feng, Dan Lu, Yan Liu, Yu Liu, Suping Guo, Naijun Han, Xiangyang Liu, Yousheng Mao, Jie He, Shujun Cheng, Yanning Gao, and Kaitai Zhang

53642-53653 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Decitabine-based chemotherapy followed by haploidentical lymphocyte infusion improves the effectiveness in elderly patients with acute myeloid leukemia https://doi.org/10.18632/oncotarget.11183 Yu Jing, Xiangshu Jin, Lixin Wang, Liping Dou, Quanshun Wang, Yushi Yao, Shimei Lian, Jihao Zhou, Haiyan Zhu, Zilong Yao, Lijun Gao, Lili Wang, Yonghui Li, Xuefeng Bai, Meiyun Fang, and Li Yu

53654-53663 Abstract | PDF | HTML | Order a Reprint Tumor heterogeneity assessed by texture analysis on contrast-enhanced CT in lung adenocarcinoma: association with pathologic grade https://doi.org/10.18632/oncotarget.15399 Ying Liu, Shichang Liu, Fangyuan Qu, Qian Li, Runfen Cheng, and Zhaoxiang Ye

53664-53674 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in targeted therapy of lung squamous cell carcinoma patients with EGFR mutation: a pooled analysis https://doi.org/10.18632/oncotarget.15726 Jingqi Zhuang, Yongfeng Yu, Ziming Li, and Shun Lu

53675-53683 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Effect of age on long-term outcomes after stroke with atrial fibrillation: a hospital-based follow-up study in China https://doi.org/10.18632/oncotarget.15729 Tao Wang, Bin Li, Hongfei Gu, Yongzhong Lou, Xianjia Ning, Jinghua Wang, and Zhongping An

53684-53690 Abstract | PDF | HTML | Order a Reprint Dynamic changes in serum cytokine levels and their clinical significance in predicting acute GVHD https://doi.org/10.18632/oncotarget.15738 Chunyan Zhang, Wenrong Huang, Pengjun Zhang, Qingyi Zhang, Guanghong Guo, Feng Gu, Hua Yang, Yurong Wang, Xueliang Huang, Qian Jia, and Yaping Tian

53691-53700 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Methotrexate plus idarubicin improves outcome of patients with primary central nervous system lymphoma https://doi.org/10.18632/oncotarget.15899 Ni Fan, Lu Zhang, Xiaoping Xu, Bobin Chen, Chen Zhu, Pei Li, Zi Chen, Tianling Ding, Yan Ma, Yan Yuan, and Zhiguang Lin

53701-53713 Abstract | PDF | HTML | Order a Reprint Gender differences in fibrosis remodeling in patients with long-standing persistent atrial fibrillation https://doi.org/10.18632/oncotarget.16342 Zhi Li, Zengwei Wang, Zongtao Yin, Yuji Zhang, Xiaodong Xue, Jinsong Han, Yan Zhu, Jian Zhang, Maximilian Y. Emmert, and Huishan Wang

53714-53729 Abstract | PDF | HTML | Supplementary Information | Order a Reprint

Safety and efficacy of p62 DNA vaccine ELENAGEN in a first-in-human trial in patients with advanced solid tumors https://doi.org/10.18632/oncotarget.16574 Dmitry M. Ponomarenko, Irina D. Klimova, Yulia A. Chapygina, Viktoria V. Dvornichenko, Natalia V. Zhukova, Rashida V. Orlova, Georgy M. Manikhas, Alexandr V. Zyryanov, Lilya A. Burkhanova, Irina I. Badrtdinova, Basile N. Oshchepkov, Elena V. Filippova, Sergei V. Orlov, Sergei I. Kolesnikov, Albert A. Sufianov, Svetlana R. Baum, Olga Y. Zaitzeva, Andrey B. Komissarov, Mikhail P. Grudinin, Oleg I. Kiselev, Anatoly F. Tsyb, Franco Venanzi, Vita Shcherbinina, Andrey Chursov, Vladimir L. Gabai, and Alexander M. Shneider

53730-53739 Abstract | PDF | HTML | Supplementary Information | Order a Reprint To predict the radiosensitivity of nasopharyngeal carcinoma using intravoxel incoherent motion MRI at 3.0 T https://doi.org/10.18632/oncotarget.17367 Wen Bo Chen, Bin Zhang, Long Liang, Yu Hao Dong, Guan Hui Cai, Chang Hong Liang, Bo Wen Lan, and Shui Xing Zhang

53740-53750 Abstract | PDF | HTML | Order a Reprint

Reviews

Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot? https://doi.org/10.18632/oncotarget.17910 Sabrina Lagniau, Kevin Lamote, Jan P. van Meerbeeck, and Karim Y. Vermaelen

53751-53762 Abstract | PDF | HTML | Supplementary Information | Order a Reprint Advances in single-cell RNA sequencing and its applications in cancer research https://doi.org/10.18632/oncotarget.17893 Sibo Zhu, Tao Qing, Yuanting Zheng, and Leming Shi

53763-53779 Abstract | PDF | HTML | Order a Reprint Transforming growth factor : A potential biomarker and therapeutic target of ventricular remodeling https://doi.org/10.18632/oncotarget.17255 Yuan Ma, Hai Zou, Xing-Xing Zhu, Jie Pang, Qiang Xu, Qin-Yang Jin, Ya-Hui Ding, Bing Zhou, and Dong-Sheng Huang

53780-53790 Abstract | PDF | HTML | Order a Reprint The involvement of DARPP-32 in the pathophysiology of schizophrenia https://doi.org/10.18632/oncotarget.17339 Haitao Wang, Mohd Farhan, Jiangping Xu, Philip Lazarovici, and Wenhua Zheng

53791-53803 Abstract | PDF | HTML | Order a Reprint Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health https://doi.org/10.18632/oncotarget.17479 Shao-Qin Ge, Sheng-Li Lin, Zheng-Hui Zhao, and Qing-Yuan Sun

53804-53818 Abstract | PDF | HTML | Order a Reprint

Succinate: An initiator in tumorigenesis and progression https://doi.org/10.18632/oncotarget.17734 Ting Zhao, Xianmin Mu, and Qiang You

53819-53828 Abstract | PDF | HTML | Order a Reprint

Microbiota-gut-brain axis and the central nervous system https://doi.org/10.18632/oncotarget.17754 Xiqun Zhu, Yong Han, Jing Du, Renzhong Liu, Ketao Jin, and Wei Yi

53829-53838 Abstract | PDF | HTML | Order a Reprint The role of Notch signaling in gastric carcinoma: molecular pathogenesis and novel therapeutic targets https://doi.org/10.18632/oncotarget.17809 Yizheng Yao, Ying Ni, Jiawen Zhang, Hua Wang, and Shihe Shao

53839-53853 Abstract | PDF | HTML | Order a Reprint Strategies targeting angiogenesis in advanced non-small cell lung cancer https://doi.org/10.18632/oncotarget.17957 Jun Wang, Jianpeng Chen, Yan Guo, Baocheng Wang, and Huili Chu

53854-53872 Abstract | PDF | HTML | Order a Reprint

Meta-Analysis Genetic association between TNF- promoter polymorphism and susceptibility to squamous cell carcinoma, basal cell carcinoma, and melanoma: A meta-analysis https://doi.org/10.18632/oncotarget.17179 Ning Liu, Guang-Jing Liu, and Juan Liu

53873-53885 Abstract | PDF | HTML | Supplementary Information | Order a Reprint

Corrections Correction: Deciphering the role of nuclear and cytoplasmic IKK in skin cancer https://doi.org/10.18632/oncotarget.20001 Josefa P. Alameda, Miriam Gaspar, Ángel Ramírez, Manuel Navarro, Angustias Page, Cristian Suárez-Cabrera, M. Guadalupe Fernández, Jose R. Mérida, Jesús M. Paramio, Rosa A. García-Fernández, M. Jesús Fernández-Aceñero, and M. Llanos Casanova

53886-53886 Correction | PDF Correction: IKK regulates the stratification and differentiation of the epidermis: implications for skin cancer development https://doi.org/10.18632/oncotarget.20002 Josefa P. Alameda, Manuel Navarro, Ángel Ramírez, Angustias Page, Cristian Suárez-Cabrera, Dong-Ming Su, Jesús M. Paramio, María del Carmen Fariña, Marcela Del Río, María Jesús Fernández-Aceñero, Ana Bravo, and María de los Llanos Casanova

53887-53887 Correction | PDF

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Since 2013, four members of Oncotarget/Oncoscience/Gerotarget have won the Breakthrough Prize, the highest prize ever: Bert Vogelstein, Michael N. Hall, Alexander Varshavsky, Stephen J. Elledge