Idea Transcript
Medicines Q&As Q&A 357.2
What are the excipients in toothpastes? Prepared by UK Medicines Information (UKMi) pharmacists for NHS healthcare professionals Before using this Q&A, read the disclaimer at www.ukmi.nhs.uk/activities/medicinesQAs/default.asp Date prepared: December 2012
Summary Toothpastes contain excipients which can cause adverse reactions affecting the mouth and lips, and systemic hypersensitivity. The excipients most commonly implicated are flavourings such as spearmint, peppermint, fennel, cinnamon and cassia oil, but preservatives, foaming agents, antibacterials, pyrophosphates and essential oils can also cause adverse reactions. This Medicines Q&A lists the toothpastes widely available in the UK and the excipients they contain which have been associated with adverse reactions or may be undesirable.
Background Toothpastes contain a large number of excipients including fluoride, abrasives, detergents, binding agents, humectants, preservatives, colouring agents, antiseptics and flavourings [1]. There are reports that some of these excipients cause adverse oral reactions such as cheilitis (due to allergic or irritant contact dermatitis – ACD and ICD), peri-oral eczema, stomatitis, lichenoid reactions, burning mouth syndrome, loss of taste and systemic reactions such as anaphylaxis and rhinitis [1-23]. In a retrospective study of 202 patients referred to a tertiary dermatology centre with eczematous cheilitis, 25.9% of cases were caused by toothpastes, the second most common cause after lip cosmetics [2]. The excipients most commonly implicated are flavourings (and their active compounds) – spearmint (carvone), peppermint (menthol), fennel (anethole) and cinnamon or cassia oil (cinnamic aldehyde) [1,3,4]. Others that have been reported to cause contact allergic reactions include the antibacterial, triclosan [5], foaming agents such as cocamidopropyl betaine [6] and sodium lauryl sulphate [7,8], and preservatives such as parabens [2], polyethylene glycol [9] and sodium benzoate [10]. Pyrophosphates in tartar-control toothpastes have caused ICD with ulceration, sloughing, erythema, fissuring and a burning sensation [11,12]. Tartar-control toothpastes containing pyrophosphates can be a particular problem as they contain higher concentrations of flavourings and detergents to mask the bitter taste of these compounds and increase their solubility [11,12]. Essential oils (tea tree oil and propolis) [3,24] and fragrances (limonene and linalool) [25] have also been reported to cause allergy. For patients who experience adverse effects that are thought to be due to their toothpaste, changing to another product that does not contain the suspected excipient results in complete resolution of symptoms within a few weeks or months [3,6,11,12,15,16,18,19,26]. If ACD is suspected, patch testing can be helpful in identifying the likely allergen [27,28].
Answer The following table is a list of toothpastes widely available in the UK and the excipients they contain which are associated with irritant or allergic reactions affecting the mouth and lips, or systemic adverse effects. It can be used to choose a suitable product that does not contain excipients suspected to be the cause of adverse reactions. The table also includes fluoride content, and sweeteners and other excipients which may be undesirable. Key:
CAPB cocamidopropyl betaine PEG polyethylene glycol PP pyrophosphate
NS PPM SLS
detail not specified parts per million sodium lauryl sulphate
Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
1
Medicines Q&As Toothpaste name and manufacturer
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
Pyrophosphate
Other excipients Other
Sweetener
Alcohol
Aloe Dent by Optima Consumer Health (Telephone 01274 526360) Children’s Aloe & Green Tea (tube)
None
Tea tree
Aroma NS
Children’s Aloe Vera (tube)
None
Tea tree
Aroma NS
Sensitive Aloe Vera (tube)
None
Tea tree
Sensitive Aloe Vera with Fluoride (tube)
1500
Tea tree
Triple Action Aloe Vera (tube)
None
Tea tree
Triple Action Aloe Vera with Fluoride (tube)
1500
Tea tree
Whitening Aloe Vera (tube)
None
Tea tree
Whitening Aloe Vera with Fluoride (tube)
1500
Tea tree
Menthol Peppermin t Menthol Peppermin t Menthol Peppermin t Menthol Peppermin t Menthol Peppermin t Menthol Peppermin t
Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol
Aquafresh by GlaxoSmithKline Consumer (Telephone 020 8047 2500) Big Teeth 6+ years (tube) Extreme Clean Pure Breath (tube) Extreme Clean Pure Breath Whitening (tube) Extreme Clean Whitening (tube)
1400 1400 1400 1400
Aroma NS Aroma NS Aroma NS Citral Aroma NS Citral
SLS SLS CAPB SLS CAPB SLS
Limonene Limonene
PEG-6 PEG-6 PEG-6
Sorbitol Sorbitol Sorbitol
Saccharin Saccharin Saccharin
PEG-6
Sorbitol
Saccharin 2
Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer Fresh and Minty (pump/tube) Iso-Active Fresh Mint Foaming gel (pump) Iso-Active Triple Protection Whitening Cool Mint (pump)
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
1450 1450
Aroma NS Aroma NS
Limonene Limonene
1450
Aroma NS
SLS CAPB SLS CAPB SLS
Limonene
Pyrophosphate
Other excipients Other
Sweetener
PEG-6 PEG-6
Sorbitol Sorbitol
Saccharin Saccharin
PEG-6
Sorbitol
Saccharin
Parabens PEG-6 PEG-6
Xylitol
Saccharin
Sorbitol Sorbitol Sorbitol
Saccharin Saccharin Saccharin
Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol Sorbitol
Saccharin
Alcohol
Aquafresh by GlaxoSmithKline Consumer (Telephone 020 8047 2500) Little Teeth 4-6 years (tube)
1400
Aroma NS
Mild and Minty (pump/tube) Milk Teeth 0-3 years (tube) Multi-Action+Whitening (pump/tube)
1450 1000 1450
Aroma NS Aroma NS Aroma NS
SLS SLS SLS
Limonene Limonene Limonene
PEG-6
Arm and Hammer by Church and Dwight UK (Telephone 01303 858735) No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website
Advance White (tube) Advance White Sensitive (tube) Brilliant Sparkle gel (tube) Enamel Care (tube) Enamel Care Sensitive (tube) Max Booster (tube) Original Coolmint (tube)
Beverly Hills Formula by Purity Laboratories (Telephone 00 353 1842 6611 - ROI) Dentist’s Choice Gum & Whitening Expert (tube) Natural White (tube)
1000
Natural White Gentle Sensitive (tube) Natural Whitening Expert (tube)
1000
1000
None
Triclosan
Doublemin t Doublemin t Doublemin t Herbalmint
SLS
Limonene
SLS
Limonene
SLS
Limonene
SLS
PEG-32
PEG-1500
Saccharin Saccharin Saccharin 3
Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Perfect White (tube)
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
1400
Fragranc e
Preservative/ Solvent
Peppermin CAPB t SLS Perfect White Sensitive (tube) 1400 Peppermin CAPB t SLS Beverly Hills Formula by Purity Laboratories (Telephone 00 353 1842 6611 - ROI)
Limonene
PEG-32
Limonene
PEG-32
Sensitive Whitening Expert (tube)
1000
SLS
Limonene
Total Breath Whitening (tube)
1300
SLS
Limonene
Total Enamel Sensitive (tube)
1300
SLS
Limonene
Total Protection Whitening (tube)
1000
SLS
Limonene
Triclosan
Triclosan
Doublemin t Peppermin t Peppermin t Doublemin t
Pyrophosphate Tetrasodiu m PP Tetrasodiu m PP
PEG-32
PEG-32
Other excipients Other
Sweetener
Xylitol Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol Sorbitol Xylitol
Saccharin
Alcohol
Saccharin Saccharin Saccharin
Biosis by Biosis (Telephone 0845 004 4844) Alba Pura Neutral toothpowder (tub)
None
Biotene by GlaxoSmithKline Consumer (Telephone 020 8047 2500) Fluoride for People with a Dry Mouth (tube)
Aroma NS Menthol
1000
Sodium benzoate
Calcium PP
Sorbitol Xylitol
BioXtra by Life Stream Pharma (Telephone 07711 088164) Moisturising (tube)
1500
Menthol Anethole
Limonene Linalool
Sodium benzoate
Sorbitol Xylitol
Eugenol Limonene
Benzylalcohol PEG-32
Sorbitol Xylitol
BlanX by Acdoco (Telephone 0845 0178 000) Active Enamel Protection (pump)
890
Aroma NS
SLS
Saccharin
4 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Advanced Whitening (pump)
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
890
BlanX by Acdoco (Telephone 0845 0178 000) Classic White (tube) 890
Extrawhite Intensive Whitening Treatment (pump)
792
Intensive Stain Removal (pump)
890
Sensitive Teeth (pump)
890
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
Pyrophosphate
Other excipients Other
Sweetener
Sodium benzoate Parabens PEG-32
Sorbitol Xylitol
Saccharin
Sorbitol Xylitol
Saccharin
Sorbitol
Saccharin
Anethole Menthol Peppermin t
SLS
Eugenol Limonene
Anethole Menthol Peppermin t Anethole Menthol Peppermin t Anethole Aroma NS Menthol Peppermin t Aroma NS
SLS
Eugenol
Parabens PEG-32
SLS
Eugenol
Parabens PEG-32
SLS
Eugenol
Parabens PEG-32
Sorbitol Xylitol
Saccharin
Benzylalcohol Parabens PEG-32
Sorbitol Xylitol
Saccharin
Peppermin t Aroma NS
SLS
Eugenol
Sorbitol
Saccharin
SLS
Limonene
Sodium benzoate Parabens PEG-8
Sorbitol
Saccharin
SLS
Tetrapotassium PP
Alcohol
Brilliant by Lornamead (Telephone 01276 674000) Daily Advanced Whitening (tube)
1100
Gentle Whitening (tube)
1450
5 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Fluorid e (ppm)
Sparkling Whitening (tube)
1450
Whitening Booster gel (tube)
None
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
Pyrophosphate
Other excipients Other
Sweetener
Sorbitol
Saccharin
Sorbitol
Saccharin
CAPB SLS
Propylene glycol Parabens PEG-8 Sodium benzoate
Aroma NS
SLS
Parabens
Sorbitol
Saccharin
PEG-12 Polyethylene PEG-12 Polyethylene PEG-12
Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin Saccharin
Aroma NS
SLS
Alcohol
Clinomyn by EC DeWitt / Lornamead (Telephone 01276 674000) Smokers (tube)
1000
Colgate by Colgate-Palmolive (Telephone 01483 302222) Advanced White with microcleansing crystals (pump/tube) Advanced White Go Pure (tube)
1450
Aroma NS
SLS
Limonene
1450
Aroma NS
SLS
Limonene
Anti Tartar Plus Whitening (tube)
1450
Aroma NS
SLS
Limonene
Blue Minty Gel (tube) Cavity Protection (pump/tube)
1450 1450
Aroma NS Aroma NS
SLS SLS
Limonene Limonene
PEG-12
Cool Stripe (pump/tube) Deep Clean Whitening (pump/tube)
1450 1100
Aroma NS Aroma NS
SLS SLS
Limonene Limonene
PEG-12
Duraphat 2800ppm (tube)
2800
SLS
Macrogol 600
Duraphat 5000ppm (tube)
5000
Mint flavour NS Anethole Carvone Menthol
SLS
Macrogol 600 Sodium benzoate
Tetrasodiu m PP Tetrasodiu m PP
Saccharin Saccharin
Tetrapotassium PP
Sorbitol
Saccharin
Sorbitol
Saccharin
6 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Max Fresh with cooling crystals (clean mint) (pump/tube) Max Fresh with cooling crystals (cool mint) (bottle) Max Fresh with cooling crystals (cool mint) (pump/tube) Max Fresh with mouth-wash beads (tingling mint) (pump/tube) Max Fresh Night (tube)
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
1450 1000 1450 1450 1450
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
Peppermin t Spearmint Aroma NS Menthol Aroma NS Menthol Aroma NS Menthol Aroma NS Menthol Aroma NS Menthol
CAPB SLS CAPB SLS CAPB SLS CAPB SLS CAPB SLS
Limonene
PEG-12
Limonene
PEG-12
Limonene
PEG-12
Limonene
PEG-12
Limonene
PEG-12
Limonene
PEG-12
Limonene
Eugenol Limonene Eugenol Limonene Eugenol Limonene
PEG-12 Polyethylene PEG-12 Polyethylene PEG-12 Polyethylene Polyethylene Propylene glycol PEG-12
Pyrophosphate
Tetrasodiu m PP
Tetrasodiu m PP
Other excipients Other
Sweetener
Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin
Lactose Sorbitol Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin
Alcohol
Saccharin
Colgate by Colgate-Palmolive (Telephone 01483 302222) Max White with white micro-crystals (pump/tube) Max White One (tube)
1450
Aroma NS
1450
Aroma NS
Max White One Active (tube)
1450
Aroma NS
Max White One Fresh (tube)
1450
Aroma NS
Oxygen (tube)
1000
Aroma NS
CAPB SLS CAPB SLS CAPB SLS CAPB SLS SLS
Sensitive Enamel Protect (pump/tube) Sensitive Multi Protection (pump/tube) Sensitive Plus Whitening (pump/tube)
1450
Aroma NS
SLS
1450
Aroma NS
SLS
1450
Aroma NS
SLS
Limonene
Limonene
PEG-12 PEG-12
Tetrasodiu m PP Tetrapotassium PP Tetrapotassium PP Tetrapotassium PP
Saccharin
Tetrasodiu m PP Tetrapotassium PP Tetrasodiu m PP
Saccharin Saccharin Sorbitol
Saccharin 7
Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
Pyrophosphate
Other excipients Other
Sweetener Potassium acesulfame Sucralose Saccharin
Sensitive Pro-Relief (tube)
1450
Aroma NS
SLS
Sorbitol
Sensitive Pro-Relief Enamel Repair (tube) Sensitive Pro-Relief Multi Protection (tube)
1450
Aroma NS
SLS
Sorbitol
1450
Aroma NS
SLS
Sorbitol
Sensitive Pro-Relief Whitening (tube)
1450
Aroma NS
SLS
Sorbitol
Aroma NS
SLS
Limonene
Aroma NS Cinnamal Menthol Aroma NS
SLS
Eugenol Limonene
SLS SLS
Limonene Limonene
SLS SLS SLS
Limonene Eugenol Limonene Limonene
SLS
Limonene
Colgate by Colgate-Palmolive (Telephone 01483 302222) Smiles 0-3 years (tube) 1000 Smiles 4-6 years (tube)
1450
Smiles 6+ years (tube) Total Advanced (pump/tube)
1450 1450
Triclosan
Total Advanced Clean (pump/tube) Total Advanced Freshening (pump/tube) Total Advanced Enamel Protect (tube) Total Advanced Whitening (pump/tube)
1450 1450
Triclosan Triclosan
1450
Triclosan
1450
Triclosan
Mint flavour (89854) Aroma NS Aroma NS Cinnamal Aroma NS Menthol Aroma NS
Alcohol
Potassium acesulfame Sucralose Potassium acesulfame Sucralose
PEG-12 Polyethylene PEG-12
Sorbitol
Saccharin
Sorbitol
Saccharin
PEG-12
Sorbitol
Saccharin Saccharin
Saccharin Saccharin Saccharin Sorbitol
Saccharin
8 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Mint flavour Peppermin t Aroma NS Aroma NS Aroma NS Aroma NS
SLS
Total Pro Gum Health (tube)
1450
Triclosan
Total Pro Gum Health Tartar Control (tube) Total Sensitive (tube) Triple Action (tube) White and Fresh Breath (tube) Whitening 2 in 1 liquid toothpaste (bottle)
1450
Triclosan
1450 1450 1450 1100
Triclosan
Fragranc e
Preservative/ Solvent
Pyrophosphate
Propylene glycol Propylene glycol
SLS SLS SLS SLS CAPB SLS
Limonene Limonene Limonene Limonene
CAPB
Limonene
Other excipients Other
Sweetener
Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin Saccharin Saccharin Saccharin
PEG-12 PEG-12 Tetrasodiu m PP
Alcohol
Corsodyl by GlaxoSmithKline Consumer (Telephone 020 8047 2500) Daily Gum & Toothpaste (tube)
1400
Peppermin t
Sodium benzoate
Saccharin
Crest by Procter and Gamble (Telephone 08000 850367) Complete 5 Extra Fresh/ Mild Fresh (tube) Complete Extra Whitening (tube) Decay Prevention Fresh Mint/Mild Mint (tube) Extra Whitening (tube) Fresh Breath & Whitening Fresh Mint (tube) Kids (tube) Tartar Control (tube)
No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website
Dr Organic by Dr Organic (Telephone 01792 646475) Aloe Vera Whitening (tube) Pomegranate Healthy Gums (tube) Tea tree Fresh Breath Antibacterial (tube)
No details available from the manufacturer or their website No details available from the manufacturer or their website No details available from the manufacturer or their website
Euthymol by Johnson and Johnson (Telephone 01628 822222) 9 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer Original (tube)
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
None
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
Aroma NS
SLS
Peppermin t Peppermin t
SLS
Parabens
SLS
Parabens
Pyrophosphate
Other excipients Other
Sweetener
Sorbitol
Saccharin
Sorbitol Xylitol Sorbitol Xylitol
Saccharin
Sorbitol
Saccharin Sucralose
Alcohol
Janina by Brodie & Stone (Telephone 020 7299 7400) Ultrawhite Diamond Formula Extra Strength Whitening (tube) Ultrawhite Sensitive Whitening (tube)
1500 1500
Tetrasodiu m PP Tetrasodiu m PP
Saccharin
Kingfisher by Kingfisher Natural Toothpaste (Telephone 01603 630484) Aloe Vera, Tea Tree and Fennel fluoride-free (tube) Aloe Vera, Tea Tree and Mint fluoride-free (tube)
None
Tea tree
None
Tea tree
Fennel
SLS
Limonene
Fennel SLS Peppermin t Baking Soda Mint fluoride-free None Peppermin SLS (tube) t Spearmint Kingfisher by Kingfisher Natural Toothpaste (Telephone 01603 630484)
Limonene
Fennel with fluoride (tube)
1050
SLS
Limonene
Fennel fluoride-free (tube)
None
SLS
Limonene
Mint with fluoride (tube)
1050
SLS
Limonene
Mint fluoride-free (tube)
None
SLS
Limonene
CAPB SLS
Limonene
Anethole Fennel Anethole Fennel Fennel Peppermin t Fennel Peppermin t
Limonene
MacLeans by GlaxoSmithKline Consumer (Telephone 020 8047 2500) Confidence White and Clean (pump)
1450
Aroma NS
PEG-6
10 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
SLS SLS CAPB SLS SLS CAPB SLS SLS SLS CAPB
Limonene Limonene Limonene
Fresh Mint (pump/tube) Ice Whitening gel (tube) Total Health (pump)
1400 1450 1400
Aroma NS Aroma NS Aroma NS
Total Health (tube) Total Health Whitening (pump/tube)
1400 1400
Aroma NS Aroma NS
White & Shine (tube) Whitening (pump/tube)
1450 1450
Aroma NS Aroma NS
Pyrophosphate
Other excipients Other
Sweetener
PEG-6 PEG-6 PEG-6
Sorbitol Sorbitol Sorbitol
Saccharin Saccharin Saccharin
Limonene
PEG-6 PEG-6
Sorbitol Sorbitol
Saccharin Saccharin
Limonene Limonene
PEG-8 PEG-6
Sorbitol Sorbitol
Saccharin Saccharin
Sorbitol
Saccharin
Alcohol
Oral-B by Procter and Gamble (Telephone 08000 850367) No details available from the manufacturer or their website 1-2-3 (tube) No details available from the manufacturer or their website Complete Extra Fresh/Extra White (tube) No details available from the manufacturer or their website Complete Mouthwash & Whitening (tube) No details available from the manufacturer or their website Pro-Expert All Around Protection Clean Mint/ Mild Mint (tube) Oral-B by Procter and Gamble (Telephone 08000 850367) No details available from the manufacturer or their website Pro-Expert Enamel Shield (tube) Pro-Expert Sensitive & Gentle Whitening (tube) No details available from the manufacturer or their website No details available from the manufacturer or their website Pro-Expert Whitening (tube) No details available from the manufacturer or their website Stages Berry (tube) Pearl Drops by Church and Dwight UK (Telephone 01303 858735) Daily Every Day White (bottle)
Daily Pro-White (bottle)
1450
Aroma NS
SLS
Limonene
PEG-12
Tetrasodiu m& tetrapotassium PP
No details available from the manufacturer or their website 11 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Fluorid e (ppm)
Nourish & Protect Sensitive Smile (bottle) Nourish & Protect Youthful Smile 1000 (bottle)
Transform Hollywood Smile (bottle) Transform Now Smile (bottle) Transform Now Smile Corrector (bottle)
1300 1000 None
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
No details available from the manufacturer or their website Aroma NS SLS Limonene PEG-8 PEG/PPG116/66 copolymer Aroma NS Limonene PEG-12 Aroma NS SLS Limonene PEG-12 Aroma NS Limonene Linalool
Pyrophosphate
Other excipients Other
Sweetener
Alcohol
Saccharin
Sorbitol Sorbitol
Saccharin Saccharin
Sorbitol
Sorbitol
Potassium acesulfame Saccharin Saccharin
Sorbitol
Saccharin
Sorbitol Sorbitol
Saccharin Saccharin Sucralose Saccharin
Alcohol Alcohol
Rapid White by Lornamead (Telephone 01276 674000) Daily Whitening (tube)
1100
Peppermin t
CAPB
Triple Action Whitening Booster Gel (tube)
None
Peppermin t
CAPB SLS
Limonene
Sodium benzoate Polyethylene Sodium benzoate
Rembrandt by Gillette Group UK /Procter and Gamble (Telephone 08000 850367) No details available from the manufacturer or their website
Plus (tube)
Sensodyne by GlaxoSmithKline Consumer (Telephone 020 8047 2500) Extra Fresh (tube)
1450
Gum Protection (tube) Multi Action Daily for Sensitive Teeth (pump) Original (tube)
1450 1450 None
Aroma NS Cinnamal Aroma NS Aroma NS Cassia oil Levomenthol Spearmint
CAPB
Limonene
CAPB CAPB
Limonene Limonene
PEG-6
Limonene
PEG-40
Methylsalicylate Sorbitol
12 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Fragranc e
Preservative/ Solvent
CAPB
Limonene
CAPB CAPB
Pronamel Daily (tube)
1450
Peppermin t Aroma NS
Pronamel Gentle Whitening (tube) Pronamel Daily Fluoride for Children 6-12 (tube) Rapid Relief (pump) Rapid Relief (tube)
1450 1450
Aroma NS Aroma NS
1040 1040
Aroma NS
Total Care Gel (tube)
1450
Total Care Gentle Whitening (pump/tube)
1400
Anethole Carvone Menthol Peppermin t Aroma NS Cinnamal Aroma NS
CAPB
Other
Sweetener
Alcohol
PEG-6
Sorbitol
Saccharin
Anise alcohol
Limonene Limonene
PEG-6 PEG-6
Sorbitol Sorbitol
Limonene Limonene
Parabens Parabens
Sorbitol Sorbitol
Saccharin Saccharin Sucralose Saccharin Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin
Sorbitol
Saccharin
Limonene
CAPB
PEG-6
Pyrophosphate
Other excipients
UltraDEX (formerly RetarDEX) by Periproducts (Telephone 0208 868 1500) Low Abrasion (tube)
1000
Menthol Peppermin t Spearmint
UltraDEX (formerly RetarDEX) by Periproducts (Telephone 0208 868 1500) Recalcifying & Whitening (tube) 1000 Menthol Peppermin t Spearmint
Limonene
Limonene Linalool
Saccharin
Weleda by Weleda UK (Telephone 0115 944 8222) 13 Medicines Q&A 357.2 What are the excipients in toothpastes?
From the NHS Evidence website www.evidence.nhs.uk
Medicines Q&As Toothpaste name and manufacturer
Fluorid e (ppm)
Excipients associated with adverse reactions (see Limitations) Antibacterial
Flavourin g
Foamin g agent
Fragranc e
Calendula (tube)
None
Aroma NS
Limonene
Childrens Tooth Gel (tube)
None
Limonene
Plant Gel (tube)
None
Salt (tube)
None
Ratanhia (tube)
None
Fennel Spearmint Fennel Peppermin t Spearmint Aroma NS Menthol Fennel Peppermin t Spearmint
Preservative/ Solvent
Pyrophosphate
Other excipients Other
Sweetener
Alcohol Alcohol