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Science & Technology Science Archives » 2011 & 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 October 24, 2011 Bryostatins Retain Promise (October 24, 2011 | Vol. 89 Issue 43 | pp. 10-17) New results in total synthesis reinvigorate a 40-year-old field of research. For Cave's Art, An Uncertain Future (October 24, 2011 | Vol. 89 Issue 43 | pp. 38-40) Disagreement on conservation course of action complicates a potential reopening. Cancer Stem Cells (October 24, 2011 | Vol. 89 Issue 43 | pp. 41-43) Researchers zero in on the pathways that allow cancer to bounce back after treatment. What's That Stuff? Blue Jeans (October 24, 2011 | Vol. 89 Issue 43 | p. 44) Making the iconic pants requires both color-addition and color-removal chemistry. Shedding Nanoparticles (October 24, 2011 | Vol. 89 Issue 43 | p. 5) Materials Science: Chemists observe metal objects sloughing off ions to form nanoparticles. Modifying Messenger RNA (October 24, 2011 | Vol. 89 Issue 43 | p. 7) Chemical Biology: Methylated bases in mRNA may have roles in gene regulation and obesity. Lab-On-A-Chip For Planets, Moons (October 24, 2011 | Vol. 89 Issue 43 | p. 8) Microfluidics: Automated chip is designed to detect extraterrestrial amino acids. New Editor For Analytical Chemistry (October 24, 2011 | Vol. 89 Issue 43 | p. 9) Publishing: Jonathan Sweedler to take the helm. Science & Technology Concentrates (October 24, 2011 | Vol. 89 Issue 43 | p. 37) Hydrogenase Spills Secret Crystallography reveals novel cluster behind oxygen tolerance, opening up new possibilities for fuel-cell applications Brainy Route To Prostaglandins Pathway produces prostaglandins differently in the brain than elsewhere in the body MOFs Sop Up Oil Fluorinated metal-organic framework materials selectively adsorb hydrocarbons Planet-Forming Disk Soaked In Cold Water Cold water from ice grains add more to picture of solar system formation and water deposition Cells Get Electric Jolt, Then A Shot

October 17, 2011 Improving Shop Safety (October 17, 2011 | Vol. 89 Issue 42 | pp. 56-57) Yale updates policies on machine shop use after student death. Cleaning Acrylics (October 17, 2011 | Vol. 89 Issue 42 | pp. 58-59) Conservation scientists seek new ways to keep modern paintings looking their best. Detecting H2 S In Vivo (Member Content) (October 17, 2011 | Vol. 89 Issue 42 | p. 60) Studies could lead to sensitive and selective analyses for tiny signaling agent. Rules For Design (October 17, 2011 | Vol. 89 Issue 42 | p. 9) Materials Science: Guidelines predict structures formed by nanoparticles and DNA linkers. Identifying Modified Cells (October 17, 2011 | Vol. 89 Issue 42 | p. 11) Molecular Biology: Technique tags and enriches cells genetically altered by nucleases. Linker-Free Molecular Wires (October 17, 2011 | Vol. 89 Issue 42 | p. 12) Electronics: Metal-carbon bonds increase electrical conductance. Asymmetry From A Guest (October 17, 2011 | Vol. 89 Issue 42 | p. 13) Stereochemistry: Enzymelike pocket that hosts chiral species controls catalyst's enantioselectivity. Science & Technology Concentrates (October 17, 2011 | Vol. 89 Issue 42 | pp. 54-56) Proteoglycan Is Sugar-Specific Venus Has A Thin Ozone Layer Peptide Patrols The Gut Raman Spots Hidden Danger Ancient Humans Were Pigment Chemists Surprise Route To Peptoid Nanosheets Lifelike Droplets Do The Dissolving Dance Linear Alkanes Polymerize On Gold

October 10, 2011 Lipids Take Charge (October 10, 2011 | Vol. 89 Issue 41 | pp. 15-20) Mass spectrometry propels the field of lipidomics. Feeding Your Gut Microbiome (Member Content) (October 10, 2011 | Vol. 89 Issue 41 | pp. 42-43) Digestive health benefits correlate with high levels of good bacteria promoted by unusual carbohydrates added to food. Bacterial Messengers (Member Content) (October 10, 2011 | Vol. 89 Issue 41 | p. 44) Method encodes and decodes text messages. C&EN Talks With Peter Murray-Rust (Member Content) (October 10, 2011 | Vol. 89 Issue 41 | p. 45) Chemistry technophile discusses his project to make laboratories smarter. Nobel Prize in Chemistry (October 10, 2011 | Vol. 89 Issue 41 | p. 7) Awards: Dan Shechtman wins for discovery of convention-bucking quasicrystals. With Video Nobel Prize In Physics (October 10, 2011 | Vol. 89 Issue 41 | p. 8) Awards: Three share honor for discovering accelerating expansion of the universe National Chemistry Week (October 10, 2011 | Vol. 89 Issue 41 | p. 9) "Chemistry—Our Health, Our Future!" is this year's theme. New Cancer Vaccine Strategy (October 10, 2011 | Vol. 89 Issue 41 | p. 10) Cancer Treatment: Two-headed molecule summons immune-system attack. Making Dinitrogen (October 10, 2011 | Vol. 89 Issue 41 | p. 10) Environment: Pathway involves microbial oxidation of ammonia via nitric oxide and hydrazine. Nobel Prize In Physiology Or Medicine (October 10, 2011 | Vol. 89 Issue 41 | p. 11) Awards: Three researchers share prize for their work on immunity. Science & Technology Concentrates (October 10, 2011 | Vol. 89 Issue 41 | pp. 40-41) Stents That Heal Researchers modify artery-opening devices with peptide that triggers blood vessel repair Fluoroborate Scaled Up, Ready For Inaction Chemists solve synthetic impasse to make gram quantities of anion for electrolyte and catalyst applications Yardstick Measures Cysteines On The Move Fate of one cysteine among many is detectable with atomic force microscopy Gold Catalyzes Esterifications Nanoparticles of the precious metal and its alloys with palladium transformdiols Old-Age Blindness Risk Explained Condition attributed to gene mutation that impedes binding of malondialdehyde to gene protein Mass Spec Maps Disordered Proteins Isotope-exchange technique requires little sample to probe ordering transition Chemoenzymatic Path Yields Chiral Amides Enantioconvergent synthesis converts inexpensive racemic alpha-substituted amides into valuable enantiopure products Method Optimizes Interfering RNA High-throughput technique quickly evaluates possible RNA modifications October 3, 2011 With Mice, Urine Powers Social Networking (Member Content) (October 3, 2011 | Vol. 89 Issue 40 | pp. 36-37) Researchers are learning the secrets of mouse chemical communication by peering into their pee. Anti-HIV Trojan Horse (Member Content) (October 3, 2011 | Vol. 89 Issue 40 | p. 38) Agent invites itself into the brain and then inhibits HIV enzyme. Tweezing Apart Amyloids (October 3, 2011 | Vol. 89 Issue 40 | p. 7) Therapeutics: Small molecule sticks to lysine to unglue protein aggregates. Untangling Polymer Flow (October 3, 2011 | Vol. 89 Issue 40 | p. 9) Modeling: New algorithm closely describes dynamics of polymer melt. Catalyst Calculus (October 3, 2011 | Vol. 89 Issue 40 | p. 9) Organic Chemistry: Math teases out ideal balance of catalyst qualities. Science & Technology Concentrates (October 3, 2011 | Vol. 89 Issue 40 | pp. 34-35) Protein Signaling In Motion Mass spectrometry uncovers a crucial tugging action involved in G protein activation Silanediols Debut As New Catalyst Class Hydrogen bond donor compounds join other metal-free catalysts in the organic synthesis tool box Millipede Glow Deters Would-Be Predators For the first time, field tests show bioluminescence can function as a warning signal Nanostructures Sop Up Radioactive Ions Tiny titanate tubes and fibers could remediate contaminated water Sour-To-Sweet Miracle Mechanism Revealed Japanese researchers learn how African red berry’s glycoprotein alters human taste Hybrid Photocatalyst Produces H2Rapidly Coupling photosystem I and a cobalt complex yields an inexpensive yet active catalyst Enantiomeric Effects Of Pain Drugs Unfold Arctic Ozone Loss Qualifies As A Hole Ozone depletion in the stratosphere over the Arctic deepens, matching that of the Antarctic September 26, 2011 Personalizing Nanomedicine (Member Content) (September 26, 2011 | Vol. 89 Issue 39 | pp. 29-32) Researchers strive to tailor patient care by developing nanoparticles called theranostics that can simultaneously monitor and treat disease. Golden Year for Inorganic Chemistry (Member Content) (September 26, 2011 | Vol. 89 Issue 39 | pp. 33-35) ACS Meeting News: Inorganic Chemistry turns 50, giving inorganic chemists a reason to pause and celebrate. Voices Of Inorganic Chemistry (Member Content) (September 26, 2011 | Vol. 89 Issue 39 | pp. 33-35) Analyzing Nuclear Processes (Member Content) (September 26, 2011 | Vol. 89 Issue 39 | pp. 36-37) ACS Meeting News: Analytical chemists devise ways to watch radioactive streams. Pitcher Plant Inspires Super Slippery Surface (September 26, 2011 | Vol. 89 Issue 39 | p. 5) Materials Science: Omniphobic material mimics carnivorous plant's slick surface structure. Lowering The Brain's Drawbridge (September 26, 2011 | Vol. 89 Issue 39 | p. 8) Drug Delivery: New technique shepherds large molecules across the blood-brain barrier in mice. Longest Synthetic Oligosialic Acids (September 26, 2011 | Vol. 89 Issue 39 | p. 9) Carbohydrate Chemistry: Achievement could aid design of antibacterial vaccines. Science & Technology Concentrates (September 26, 2011 | Vol. 89 Issue 39 | pp. 27-28) Gamers Solve Protein Structure Foldit players find model that leads to solution of retroviral protease structure Cyanocuprates Boost Ketone Synthesis Approach improves direct conversion of carboxylic acids to ketones relative to organolithium reagents Reducing Shipping Air Pollution Bodes Well Researchers test the impact of California fuel regulations intended to reduce emissions from ocean-going vessels Porphyrin’s Hole Plugged By Ethylene All-organic porphyrin displays electronic properties amenable to solar energy collection Carbon-Based Thermoelectrics Carbon nanotube-polymer composites offer lightweight, flexible alternatives to classic inorganic semiconductors Shark Lipid Repels Virus Cationic sterol previously studied for other indications blocks infection by a variety of viruses Cyclic Surrogates Pass The Acid Test Cyclopentane-1,3-diones are viable options for replacing carboxylic acids in drug candidates Stretching Livens Up Electron Transport Molecular dynamics simulation shows boost in electron tunneling for elongated designer molecule September 19, 2011 A New Life for Soda Bottles (Member Content) (September 19, 2011 | Vol. 89 Issue 38 | pp. 30-32) ACS Meeting News: Symposium explores the benefits and challenges of recycling PET. Holding The Line On Weight Loss (Member Content) (September 19, 2011 | Vol. 89 Issue 38 | p. 33) ACS Meeting News: Protein and fat supplements help mountaineers reduce unwanted muscle and weight loss. Diamond Illumines Carbon Cycling (September 19, 2011 | Vol. 89 Issue 38 | p. 6) Geological Sciences: Preserved mineral inclusions yield new insights on deep-mantle geologic processes. Reimagining Life's Chemical Engines (September 19, 2011 | Vol. 89 Issue 38 | p. 7) Biochemistry: Damaged DNA building block hints at the origins of life's redox catalysts. Unclick Chemistry (September 19, 2011 | Vol. 89 Issue 38 | p. 8) Mechanochemistry: Ultrasound tugs on triazole to trigger cycloreversion reaction. Extreme Photoswitching (September 19, 2011 | Vol. 89 Issue 38 | p. 9) Microscopy: Fluorescent proteins that turn on and off many more times than usual improve superresolution methods. Science & Technology Concentrates (September 19, 2011 | Vol. 89 Issue 38 | pp. 28-29) Giant Crystals Grow Superslowly Scientists estimate that Mexican gypsum crystals took up to 1 million years to reach their current size Hemoglobin Degradation Compounds Revealed Study pinpoints heme-group displacement in nitrite-induced breakdown product Carbon-Carbon Bonds That Are Long And Strong Coupled diamondoids can take temperatures in excess of 200 °C without decomposing Staining Makes Catalytic Sites Fluoresce Imaging method correlates fluorescence intensity with catalytic activity in individual particles Rulebreaking Leads to Primary Alcohols… One-pot reaction circumvents classic tenet governing additions to double bonds …Alcohols Pair With Alkenes Water is the sole byproduct of new carbon-carbon bond formation Antagonistic Catalyst Turns Tandem Reaction Controlled installation of acidic and basic functional groups on silica produces a two-in-one catalyst Seeing Through Biological Tissue New, inexpensive optical clearing formula makes tissue samples transparent to light September 12, 2011 Chemistry Education (September 12, 2011 | Vol. 89 Issue 37 | pp. 47-55) Teachers and volunteers use their talents and passions to inspire the chemists of tomorrow. 100 Years of Gibbs Medals (Member Content) (September 12, 2011 | Vol. 89 Issue 37 | pp. 22-23) ACS Meeting News: Special symposium celebrates a century of seminal chemists. Intoxicating Chemistry (Member Content) (September 12, 2011 | Vol. 89 Issue 37 | p. 24) ACS Meeting News: In spirited research, chemists use brand-name liquors as solvents for organic syntheses. Hydrocarbons At Gulf Spill Surface (September 12, 2011 | Vol. 89 Issue 37 | p. 26) Soluble hydrocarbons dissolved in ocean, but researchers continue to debate worker safety and the fate of less soluble compounds. Reel Science: 'Contagion' (September 12, 2011 | Vol. 89 Issue 37 | p. 28) Biomedical thriller gets the science right, but at the expense of making a good movie. Cyclization Shortcut (September 12, 2011 | Vol. 89 Issue 37 | p. 9) Organic Synthesis: Combined route to complex cyclic products saves steps, improves yields. Bacterial Acid Trips (September 12, 2011 | Vol. 89 Issue 37 | p. 10) Chemical Biology: New technique reveals how pathogens endure our acidic stomachs. High-Throughput Reaction Discovery (September 12, 2011 | Vol. 89 Issue 37 | p. 10) Organic Chemistry: Method lets chemists study thousands of transformations simultaneously. Light Pulses Get Shorter (September 12, 2011 | Vol. 89 Issue 37 | p. 11) Dynamics: 'Light transients' will enable control of electrons on attosecond scale. Science & Technology Concentrates (September 12, 2011 | Vol. 89 Issue 37 | pp. 20-21) Dating Silk Minimally invasive mass spec method determines age of centuries-old fabrics. Captured CO2 Could Work As A Green Industrial Solvent Impurities in waste carbon dioxide wouldn't be an impediment for supercritical fluid-based reactions. RNA Analogs Fluoresce Brightly Synthetic mimics can help probe properties of nucleic acids. Ca2+ Indicators Show Their New Colors Family of probe molecules brings a rainbow of colors to cellular imaging. With video A Fast Flip For Hydrogen Spins Nuclei of fullerene-caged hydrogen molecules respond quickly to irradiation. Framework Compound Conducts Electrons Availability of p-type and n-type conductors may drive these crystalline materials toward electronic applications. Molecular Electric Motor Unveiled Success in designing and imaging a single-molecule motor may benefit nanotech developments Algae Gum Amps Li-Ion Batteries Inexpensive natural binder compound boosts electrode performance. September 5, 2011 Covalent Drugs Form Long-Lived Ties (February 8, 2011 | Vol. 89 Issue 6 | pp. 19-26) Irreversible inhibitors may provide unique benefits in drug development. Water For Oil (Member Content) (September 5, 2011 | Vol. 89 Issue 36 | pp. 56-59) Alberta's oil sands are a vast energy resource, but tapping them comes at the expense of a lot of water. Healing Viruses (September 5, 2011 | Vol. 89 Issue 36 | pp. 61-62) Researchers take cancer-fighting viruses from bench to bedside. Modifying Graphene Via A Classic Route (September 5, 2011 | Vol. 89 Issue 36 | p. 13) ACS Meeting News: Textbook reaction offers customized, covalent functionalization of carbon material's properties. Making Greener Flame Retardants (September 5, 2011 | Vol. 89 Issue 36 | p. 15) ACS Meeting News: Environmentally friendly films protect cotton and foam from flames and heat. Indole Changeup Yields Elusive Alkaloid (September 5, 2011 | Vol. 89 Issue 36 | p. 16) ACS Meeting News: Cyclization and nitrene insertion star in synthesis. From Dust To Snow (September 5, 2011 | Vol. 89 Issue 36 | p. 16) ACS Meeting News: Study of atmospheric dust may herald changes in weather and climate forecasting. Science & Technology Concentrates (September 5, 2011 | Vol. 89 Issue 36 | pp. 54-55) Biobased, BPA-Free Epoxies ACS Meeting News: Chemists build biobased resins from vegetable oil Method Separates Hybrid Nanoparticles ACS Meeting News: Chromatographic method purifies complex magnetic nanostructures Mass Spec May Bring ‘Bath Salts’ Bust ACS Meeting News: Isotope ratio analysis traces feedstock fingerprints in drug syntheses Nitric Oxide-Emitting Nanomaterials Kill Microbes ACS Meeting News: Silica nanorods hold promise for fighting antibiotic-resistant pathogens Molecular Velcro Stems Bloodflow ACS Meeting News: Hydrophobically modified chitosan latches onto blood cells and assembles them into a gel One Label, Five Microscopies ACS Meeting News: Metal nanoparticles can be used as universal probe for many imaging methods Understanding Oil-Paint Brittleness ACS Meeting News: Metal soaps may be key to why zinc white turns brittle faster than lead White Toxins Inspire Drug Delivery Concept ACS Meeting News: Copolymers carry RNA therapeutics into cells and release them from cell organelles August 29, 2011 Using Bacteria To Clean Water (Member Content) (August 29, 2011 | Vol. 89 Issue 35 | pp. 34-35) Utilities are starting to take advantage of naturally occurring microbes to rid drinking water of nitrate, perchlorate. A Most Important Meeting (August 29, 2011 | Vol. 89 Issue 35 | pp. 36-37) Biochemistry: A sugar that coats the human ovum and is recognized by sperm may help explain the first steps of fertilization. Diagnostic Device Heads To Field (Member Content) (August 29, 2011 | Vol. 89 Issue 35 | p. 39) Microfluidics-based test for HIV and syphilis rivals lab-based tests. C&EN Talks With Lawrence Principe (August 29, 2011 | Vol. 89 Issue 35 | p. 40) Chemist and historian studies alchemy to fully understand modern chemistry's evolution. With Video Prefab Synthesis Moves Ahead (August 29, 2011 | Vol. 89 Issue 35 | p. 5) Organic Chemistry: First stable -boryl aldehydes ease preparation of complex small molecules. Asteroid Yields Its Secrets (August 29, 2011 | Vol. 89 Issue 35 | p. 7) Space Science: Rock particles show link with meteorites, solve weathering mysteries. New Method Is Spot On (August 29, 2011 | Vol. 89 Issue 35 | p. 9) Microfluidics: Droplet-based method could help automate dried blood spot analysis. Science & Technology Concentrates (August 29, 2011 | Vol. 89 Issue 35 | pp. 32-33) Folds Direct Protein Disposal A protein’s fate in the cell’s garbage disposal system rests in part on the stability of the protein’s folded regions Phosphoserine On Demand Adjusting protein translation allows insertion of the unnatural amino acid anywhere in a protein Catalyst Atoms Pinpointed For Real Chemist characterize the active edges of an industrial MoS2 desulfurization catalyst Multiple Bradykinin States Revealed The peptide adopts at least 10 conformers in solution, explaining why its structure had only been partially characterized Scaling Up The Axinellamines A quicker, more efficient, and stereocontrolled route to a key intermediate streamlines natural product syntheses Cosmic Rays Promote Aerosol Formation Cosmic rays can incite up to a 10-fold increase in the nucleation rate of sulfuric-acid-based atmospheric aerosol particles More Hits Tallied For Cardiac Amyloidosis High-throughput screen finds new drug candidates for this heart disease that’s caused by protein aggregation Two Zeolite Structures Solved Two research groups use novel experimental and data analysis methods to reveal the structures of two distinctive zeolites August 22, 2011 Anesthesia's Awakening (August 22, 2011 | Vol. 89 Issue 34 | pp. 13-20) Chemistry informs the quest to understand anesthetics and make them better. Unnaturally Productive (Member Content) (August 22, 2011 | Vol. 89 Issue 34 | pp. 40-42) Companies advance development of protein drugs containing unnatural amino acids. Handheld IR InThe Hangar (Member Content) (August 22, 2011 | Vol. 89 Issue 34 | pp. 43-45) Boeing uses spectroscopy to monitor airplanes made of carbon-based composites. Heat Defense: Navy Uses IR To Assess Heat Damage To Planes (Member Content) (August 22, 2011 | Vol. 89 Issue 34 | p. 44) Electronic Skin (Member Content) (August 22, 2011 | Vol. 89 Issue 34 | pp. 46-47) Ultrathin devices cling to skin like temporary tattoos. With Video Disease Protein's Mistaken Identity (August 22, 2011 | Vol. 89 Issue 34 | p. 7) Biochemistry: Biologists thought -synuclein was an unfolded monomer, but new research reveals a tetramer. A Revamped Vancomycin (August 22, 2011 | Vol. 89 Issue 34 | p. 9) Medicinal Chemistry: Modified vancomycin shows promise against hard-to-treat bacteria. Kicking The Coffee-Ring Habit (August 22, 2011 | Vol. 89 Issue 34 | p. 10) Fluid Mechanics: Shift in particle shape suppresses vexing effect. Science & Technology Concentrates (August 22, 2011 | Vol. 89 Issue 34 | pp. 38-39) Nucleobases From Space Exotic purines present the strongest evidence yet that meteorites could have delivered DNA building blocks to Earth Anomeric Study Reinterpreted A computational study counters the interpretation of previous work describing differences between sugar isomers Nanoelectrochemical Maps Make A Debut A scanning probe microscopy method helps visualize electrochemical hotspots on electrode surfaces Fukushima’s Drifting Isotopes Monitored Globally dispersed radioactive iodine and sulfate from the Japanese nuclear reactor don’t appear to pose a health risk. Ocean Acidification’s Decalcifying Effects Explained In Detail Study provides clearer data on the impact of atmospheric CO2 on the calcium carbonates of coral and shellfish Antibiotic Diversity Can Be Controlled On Multiple Levels Chemists demonstrate the ability to harness three genetic controls for the selective biosynthesis of antibiotics Molecular Gels Sport New Phase Transition Solvent molecules expelled from or incorporated into molecular gel networks control the material’s opaqueness. Ginseng Compound Curbs Chemo Effects Panaxytriol analog helps alleviate the weight loss and nerve damage associated with cancer treatments in mice August 15, 2011 Body Borers (Member Content) (August 15, 2011 | Vol. 89 Issue 33 | pp. 32-35) Two neglected diseases share similar parasites and suffer the same diagnostic and treatment problems. Black-Box Chemistry (Member Content) (August 15, 2011 | Vol. 89 Issue 33 | pp. 36-37) The ease of doing computational chemistry has theorists concerned about accuracy. Nickel Unites Protons Rapidly (August 15, 2011 | Vol. 89 Issue 33 | p. 6) Catalysis: Synthetic complex can speed production of H2 by a factor of 10. Devices Reveal Hidden Messages (August 15, 2011 | Vol. 89 Issue 33 | p. 7) Materials Science: Sensors' response to surface tension can also differentiate liquids. No Progress In Nitrate Cleanup Of Mississippi River (August 15, 2011 | Vol. 89 Issue 33 | p. 8) Water Pollution: Nitrate leaving the river's basin has increased 9% since 1980, according to new study. Direct Routes To Off-Target Effects (August 15, 2011 | Vol. 89 Issue 33 | p. 9) Molecular Biology: Techniques pinpoint zinc finger nucleases' unintended genomic cuts. Science & Technology Concentrates (August 15, 2011 | Vol. 89 Issue 33 | pp. 30-31) Liquid Crystal Shines In Three Colors Mild heating and rubbing cause films to turn red, green, and yellow New Detector For Time-Of-Flight Mass Spec Nanomembrane design offers enhanced sensitivity to heavy ions Animal’s Amino Acids Go Unnatural Non-canonical amino acids incorporated into multicellular organism Making Nanotubes In The Microwave From starting materials to product, method takes less than 30 seconds Natural Product Syntheses Analyzed Mechanistic details could aid combinatorial efforts for drug discovery Examining Methane’s Slowing Increase Conflicting explanations attribute change in emission rates to human activity Supramolecular Polymerization Peptide-based molecules form tubes and helices Plasmons Enhance Solar-Cell Output Electron waves associated with core-shell particles lead to thinner better-performing devices August 8, 2011 A Puzzle Named Bengü Sezen (August 8, 2011 | Vol. 89 Issue 32 | pp. 40-43) A historic case of fraud in the chemistry community leaves many questions and issues unresolved. Scrutinizing Sunscreens (August 8, 2011 | Vol. 89 Issue 32 | pp. 44-46) Lotions containing inorganic nanoparticles draw attention of toxicologists and ire of some consumer groups. Biopharma Joins The Doping Battle (Member Content) (August 8, 2011 | Vol. 89 Issue 32 | pp. 48-50) Companies team up with international drug agency to curb athletes’ use of performance-enhancing drugs. Prenylation With A Twist (August 8, 2011 | Vol. 89 Issue 32 | p. 10) Biochemistry: Enzyme catalyzes attachment of hydrophobic modifier to peptides in a new way. Graphene From Garbage (August 8, 2011 | Vol. 89 Issue 32 | p. 13) Materials: Low-value, impure carbon sources yield high-quality graphene. Heavy-Metal Ring Bags Metal Atom (August 8, 2011 | Vol. 89 Issue 32 | p. 13) Inorganic Chemistry: Heterocycle traps an uncharged palladium atom in an odd host-guest interaction. Science & Technology Concentrates (August 8, 2011 | Vol. 89 Issue 32 | pp. 36-37) Speedier Enantiomeric Excess An achiral copper complex grabs an enantiomer and then undergoes a distinctive rotation to quickly give a positive ID DESI Tackles Large Proteins Mass spec technique known for analyzing small molecules can now be used to analyze proteins as large as 150 kilodaltons Solar-Cell Layer Comes Into View Microscopy method reveals the location and morphology of electron donor, acceptor, and blended regions in photoactive layers Death Isn’t Sweet For Tumor Cells Selectively blocking glucose transport kills kidney cancer cells in mice while leaving normal cells intact Ion Channel Guides Blood-Seeking Bats Vampire bats decide where to sink their teeth into prey with the help of a heat-sensitive ion channel protein Model Cluster Yields Clues On Calcium's Water-Splitting Role CA2+ in the Mn-Ca cluster of photosystem II appears to set up Mn 4+ to oxidize water Screening Drugs for Antimalarials High-throughput screening and gene profiling of existing drugs help identify new drug combinations to combat malaria Molecular Balances Measure Aliphatic CH- Interactions A family of conformationally flexible molecules gives chemists a means for measuring weak interactions in solution August 1, 2011 Making Films One Layer At A Time (August 1, 2011 | Vol. 89 Issue 31 | pp. 40-43) Applications of atomic layer deposition now extend well beyond electronics. With Videos Rethinking Deinking (Member Content) (August 1, 2011 | Vol. 89 Issue 31 | pp. 42-44) Climb in digital printing puts pressure on paper recycling. Detour Takes CO2 To Methanol (August 1, 2011 | Vol. 89 Issue 31 | p. 8) Sustainable Chemistry: Alternative syntheses open a door to more efficient industrial processes. Sighting Signaling (August 1, 2011 | Vol. 89 Issue 31 | p. 9) Biochemistry: Collaboration enables the first view of a receptor with its G protein. Single Atoms Mediate Reaction (August 1, 2011 | Vol. 89 Issue 31 | p. 10) Catalysis: Isolated platinum atoms remain stable and active in oxidations. Acid-To-Base Transmutation (August 1, 2011 | Vol. 89 Issue 31 | p. 10) Inorganic chemistry: First stable metal-free borylene adduct could aid catalyst design. Science & Technology Concentrates (August 1, 2011 | Vol. 89 Issue 31 | pp. 36-37) Prion’s Multiple Roles An electrochemical study suggests one of prion protein’s normal roles may be copper-driven cellular signaling New Route To Elusive Perbromate Unveiled Smooth synthesis of BrO4– has confounded chemists for generations, but a newfound approach offers a better option Water Sentenced To Solitary Confinement In A Carbon Cage Japanese researchers have managed to capture a lone water molecule inside a C60 fullerene cage Archaea May Be Key Nitrous Oxide Source The single-celled organisms, rather than bacteria, appear to make large quantities of the ozone-destroying greenhouse gas Injectable Polymer Fixes Tissue Defects Rather than grafting tissue or using a molded plastic implant, a light-cured liquid polymer gets the job done Fluorescent Labels Color Code RNA Genetically encoded labels, previously available only for tagging proteins, are now possible for RNAs Imaging Agents Form Toxic Products Iodinated chemicals used as contrast agents produce toxic compounds in drinking water treated with disinfectants A Double Dose Of Crystal-To-Crystal Transformations Rhodium complexes go through two nonreversible solid-state ligand-exchange reactions without loss of crystallinity July 25, 2011 Biomarkers Wanted (July 25, 2011 | Vol. 89 Issue 30 | pp. 40-43) Discovery of potential diagnostic tools has been plagued with problems. More Than Just Cancer: Some Biomarkers Move Toward Validation (July 25, 2011 | Vol. 89 Issue 30 | p. 43) Fishing For Biomarkers (July 25, 2011 | Vol. 89 Issue 30 | Web Exclusive) Why Water Fills Nanotubes (Member Content) (July 25, 2011 | Vol. 89 Issue 30 | p. 44) Researchers probe origin of puzzling phenomenon and discover emptying, too. One Home For Various Guests (July 25, 2011 | Vol. 89 Issue 30 | p. 7) Supramolecular Chemistry: Chemical cage captures a variety of compounds, regardless of charge. Taking Home The Gold (July 25, 2011 | Vol. 89 Issue 30 | p. 8) Academics: U.S. high school students earn two gold and two silver medals at International Chemistry Olympiad. A Personal Meter For Everything (July 25, 2011 | Vol. 89 Issue 30 | p. 9) Sensors: System allows glucose monitors to measure other analytes. The (Synthetic) Nose Knows (July 25, 2011 | Vol. 89 Issue 30 | p. 10) Bioelectronics: Chemical sensor combines olfactory proteins and carbon nanotubes to mimic biology. Blueprint For Science Education (July 25, 2011 | Vol. 89 Issue 30 | p. 11) Curriculum: Framework is supposed to yield national teaching standards by 2012. Science & Technology Concentrates (July 25, 2011 | Vol. 89 Issue 30 | pp. 38-39) A More Stable Silyl Ether Making more robust silyl ethers just got easier, thanks to a protecting group developed by Harvard University Making Better Sodium-Ion Batteries The performance of sodium-ion batteries can be markedly improved by substituting common carbon-based anode materials Getting FlaK The first X-ray structure of a membrane aspartyl protease helps explain how the enzyme does its difficult job Electrical DNA Sequencing Unveiled A light-free DNA sequencing method harnesses the same semiconductor manufacturing technology used to make computer chips Isotope Effects On Acidity Resolved The answer to a 50-year-old question about the origin of secondary isotope effects on acidity could lead to new insights on molecular structure and reactivity Computing A Four-Atom Reaction Pushing the envelope of what can be calculated by using the Schrdinger equation Grubbs Ruthenium Catalysts Explained In a bid to solve a long-standing chemical mystery and to help improve catalyst design Improving Polymer Tandem Solar Cells Blending gold nanoparticles into the layer connecting the two subcells of a polymer tandem solar cell boosts the devices performance July 18, 2011 Preserving Plastic Art (July 18, 2011 | Vol. 89 Issue 29 | pp. 29-31) Chemistry of polymer-based creations presents unique problems for conservators. Examining Explosives (Member Content) (July 18, 2011 | Vol. 89 Issue 29 | pp. 32-34) High Explosives Applications Facility researchers tackle science for national security. A Cascade Of Natural Products (July 18, 2011 | Vol. 89 Issue 29 | p. 7) Total Synthesis: Organocatalyzed domino reactions speed assembly of multiple natural products. Printing Single-Crystal Films (July 18, 2011 | Vol. 89 Issue 29 | p. 8) Electronics: Ink-jet method makes ordered semiconducting layers. Silver Solos In Lemon Circuit (July 18, 2011 | Vol. 89 Issue 29 | p. 11) Materials Chemistry: Electrochemical cell based on same-metal electrodes is a first. Science & Technology Concentrates (July 18, 2011 | Vol. 89 Issue 29 | pp. 27-28) DNA Cages Slip Into Cells Study may lead to new ways to deliver drugs and imaging agents Tissue Morphing On Patterned Surfaces Model substrate provides biologically active platform on which to study dynamic cell and tissue processes Targeting Housekeeping To Tame Tumors Molecule selectively destroys cancer cells by blocking dissipation of reactive oxygen species Mechanism Reported For Eliminylation Carbanion-based route is likely path for recently discovered post-translational protein modification One-Pot Protein Synthesis 204-residue portion of protein yields to chemical ligation Taming A Metathesis Catalyst Air-sensitive molybdenum compounds reversibly converted to stable solids Detecting Crude Oil In Water Mass Spec Method Complements Spectroscopy Techniques For Analyzing Discharged Water Cocrystal Engineering Sorts Out Ladderanes Strategy borrowed from protein chemistry helps pin down elusive isomeric structures of small organic molecules July 11, 2011 Camp Chemistry (July 11, 2011 | Vol. 89 Issue 28 | pp. 33-35) The National Organic Symposium makes for intense summertime bonding. With Photo Gallery Brett Fors: The Guy With The Namesake Ligand (July 11, 2011 | Vol. 89 Issue 28 | p. 34) Albert Matlack: The Guy With The Questions (July 11, 2011 | Vol. 89 Issue 28 | p. 35) Ancient Pigments Leave Metal Clues (Member Content) (July 11, 2011 | Vol. 89 Issue 28 | p. 36) Metallic traces on fossils hint at the shade of feathers adorning extinct birds and dinosaurs. Reports Detail A Massive Case Of Fraud (July 11, 2011 | Vol. 89 Issue 28 | p. 4) Misconduct: Documents reveal Bengü Sezen's winding trail of deception. Controlling Cell Signaling (July 11, 2011 | Vol. 89 Issue 28 | p. 6) Tissue Engineering: Preorganization allows signal-induced changes to occur faster. Promoting Global Science (July 11, 2011 | Vol. 89 Issue 28 | p. 7) Initiative: Partnerships for Enhanced Engagement in Research aims to build research capacity abroad. Protein Regulates Sunburn Pain (July 11, 2011 | Vol. 89 Issue 28 | p. 7) Drug Target: Chemokine CXCL5 boosts skin's tenderness. Mediator Gives Up A Few Secrets (July 11, 2011 | Vol. 89 Issue 28 | p. 8) Structural Biochemistry: View of transcription complex could aid mechanistic studies, drug discovery. Marye Anne Fox To Step Down (July 11, 2011 | Vol. 89 Issue 28 | p. 8) People: UC San Diego chancellor will return to chemical research and teaching next summer. Science & Technology Concentrates (July 11, 2011 | Vol. 89 Issue 28 | pp. 31-32) Stem Cells Have Unusual Base 5-Formylcytosine has been discovered as a novel genetic base in embryonic stem cell DNA Goldilocks Effect Could Govern Reactive Oxygen Species It turns out that having just the right number of radicals in cells—not too many or too few—helps inhibit cancers Iridium Illuminates Nuclei Of Living Cells A metal complex turns on and lights up nuclei by binding to histidine rather than to DNA like other imaging agents Hydrogen Peroxide Detected In Space H2 O2 is spotted in interstellar space for the first time, a finding that could refine astrochemical models involving H2 O and O2 Antibody One-Two Could Knock Out Flu Newfound antibody complements a previous antibody's flu-deactivating activity and could enable a universal flu vaccine Raman Senses Sugars On Proteins Chemists demonstrate that Raman spectroscopy can differentiate between native and glycosylated forms of proteins How Giant Algae Heal Cuts And Scrapes A sulfated coumarin is the linchpin of a marine dweller's approach to forming gelatinous plugs at injury sites Scientists Go To Great Depths For Rare-Earth Elements Deep-sea mud in the Pacific Ocean contains enough of the metals to meet the world's growing demand July 4, 2011 Itching To Know More About Itch (Member Content) (July 4, 2011 | Vol. 89 Issue 27 | pp. 27-29) Researchers endeavor to pinpoint protein receptors and nerves responsible for the torment-inducing sensation with an eye toward therapeutics. Itch's Impact: Living With Chronic Pruritus (Member Content) (July 4, 2011 | Vol. 89 Issue 27 | Web Exclusive) Insights: Heck Of A Chemist (Member Content) (July 4, 2011 | Vol. 89 Issue 27 | p. 30) It's more than just Richard Heck's science that makes him a role model. Wildfire Closes Los Alamos (July 4, 2011 | Vol. 89 Issue 27 | p. 7) Natural Disaster: Lab, city are shuttered as crews fight to contain blaze. Research Funders To Launch Open-Access, Biomedical Journal (July 4, 2011 | Vol. 89 Issue 27 | p. 10) Scholarly Publishing: Nongovernment funding bodies join forces to shake up current model. Plutonium Transport Into Cells (July 4, 2011 | Vol. 89 Issue 27 | p. 11) Chemical Biology: Transferrin delivers element, but only when accompanied by iron. Kyoto Prize To John Cahn (July 4, 2011 | Vol. 89 Issue 27 | p. 11) Honors: Materials scientist recognized for ground-breaking theories on phase transformations. Science & Technology Concentrates (July 4, 2011 | Vol. 89 Issue 27 | pp. 25-26) Virtual Drug Screen Targets Flexible RNAs Combined NMR and computational molecular dynamics helps find compounds that interact with specific RNA conformations. Iron Helps Trigger Artemisinin's Activity Study lends additional evidence to the idea that the antimalarial drug needs a helping hand from iron to kill malaria parasites. Wallabies Beat Cows In Methane Showdown Marsupial microbes could possibly be used to alter the gut microbiome of cows to cut down on greenhouse gas emissions. Rapamycin Diversifies To Fight Early Aging The immunosuppressant drug might be effective for treating progeria, the rare genetic condition that causes premature aging in children. Nitrenium Ligand Fills A Carbene Gap The triazole-based ligand fills in a missing link in the series of ubiquitous N-heterocyclic carbenes. Superresolution Sharpens Images In Live Organisms Stimulated emission depletion (STED) microscopy provides images of fluorescently labeled proteins inside C. elegans neurons. Titanium Sparks Ethane-To-Ethylene Conversion With the help of a titanium alkylidyne reagent, chemists make ethylene from ethane at room temperature. Isotopes Track Contaminant Breakdown By loading nickel onto mesoporous silica, chemists create an improved catalyst for converting ethanol into olefin building blocks. June 27, 2011 International Year of Chemistry (June 27, 2011 | Vol. 89 Issue 26 | pp. 39-70) Chemistry's contributions to the well-being of humanity are being celebrated in 2011. Isotopes Mark The Spot (Member Content) (June 27, 2011 | Vol. 89 Issue 26 | pp. 32-35) Ratios of stable isotopes help locate the origin of corpses, follow migration routes, and authenticate items as different as bottled water and expensive cheese. Peptides Block Fibril Formation (Member Content) (June 27, 2011 | Vol. 89 Issue 26 | p. 36) Computationally designed inhibitors suggest general strategy to prevent the formation of disease-causing amyloid. 2011 Green Chemistry Awards (June 27, 2011 | Vol. 89 Issue 26 | p. 11) Honors: Recipients win praise for innovations that promote sustainability. 2011 Presidential Green Chemistry Challenge Awards (June 27, 2011 | Vol. 89 Issue 26 | Web Exclusive) Honors: Annual awards recognize chemical innovations that promote sustainability. Nanoparticles Working Together (June 27, 2011 | Vol. 89 Issue 26 | p. 12) Cancer Therapy: Tiny materials 'talk' to one another to locate, treat tumors in mice. Dinosaur Thermometry (June 27, 2011 | Vol. 89 Issue 26 | p. 15) Isotope Analysis: Sauropods' body temperature was same as that of large modern mammals. Science & Technology Concentrates (June 27, 2011 | Vol. 89 Issue 26 | pp. 30-31) Histamine Receptor Structure Revealed Protein's structure may help researchers develop better antihistamine drugs A Rodent-Repelling Odor 2-Phenylethylamine in carnivores' urine sends prey scurrying Smoke Awakens Some Seeds With Cyanohydrins Glyceronitrile in smoke spurs germination needed to bring burnt forests back to life Bifunctional Solid Catalyst Metal oxide nanoparticles convert ethanol to isobutene Complementary Routes Fashion Anticancer Natural Product Polyketide natural product kibdelone C made for first time Herpes-Related Octasaccharides Inhibit Infection Sugars block virus' entry into host cells and could lead to new drugs New Focus On Mercury New spacecraft data upend planetary models, strengthen case for water ice Isotopes Track Contaminant Breakdown Pollutants' degradation processes reveal themselves in nitrogen isotope ratios June 20, 2011 Thermoelectrics Make A Comeback (Member Content) (June 20, 2011 | Vol. 89 Issue 25 | pp. 33-35) New concepts and materials invigorate a commercially active but obscure field specializing in heating, cooling, and power generation. New And Notable At ASMS (Member Content) (June 20, 2011 | Vol. 89 Issue 25 | pp. 36-37) Companies launch a variety of new instruments. Structure Of Brassinolide's Receptor Solved (June 20, 2011 | Vol. 89 Issue 25 | p. 13) Biochemistry: First look at sensor for plant hormone has implications for crop yield, protection. Promising Pom-Poms (June 20, 2011 | Vol. 89 Issue 25 | p. 14) Therapeutics: Nucleic acid structures enter cells readily, control gene expression. Olympians Of Chemistry (June 20, 2011 | Vol. 89 Issue 25 | p. 14) Four high school students will represent the U.S. at the International Chemistry Olympiad next month in Turkey. Science & Technology Concentrates (June 20, 2011 | Vol. 89 Issue 25 | p. 32) Marking Sugar’s Spot Enzyme structure reveals the secret behind the activated nitrogen that facilitates important protein modifications. Spinning Improves NMR Of Large Proteins Ultracentrifugation-NMR method reveals tough-to-determine structures Ursolic Acid Might Keep The Doctor Away Natural product found in apples is identified as a promising compound to treat age- and disease-related muscle atrophy. Fast, Sensitive DNA Sequencing Combining pyrosequencing and fluorescence measurements leads to a quick and sensitive method for analyzing DNA. Optical Imaging Of Ligand-Protein Binding Nanoscale microscopy method provides high spatial and temporal resolution. June 13, 2011 Building Small (June 13, 2011 | Vol. 89 Issue 24 | pp. 12-17) Nanotechnology makes inroads in the construction industry. Electrochromics Hit A Color Milestone (Member Content) (June 13, 2011 | Vol. 89 Issue 24 | pp. 34-35) Spray-processable conducting polymers are now available in a full palette of colors. Robert Langer Named Priestley Medalist (June 13, 2011 | Vol. 89 Issue 24 | p. 7) ACS Awards: MIT chemical engineer is honored for his influential work. Picking Off Hydrogen (June 13, 2011 | Vol. 89 Issue 24 | p. 8) Organic Synthesis: Use of palladium catalyst yields aromatic molecules from aliphatic precursors. DNA Folding In Cell-Like Setting (June 13, 2011 | Vol. 89 Issue 24 | p. 10) Structural Biochemistry: G-quadruplex structure in crowded solution revealed. Recognizing Service To ACS (June 13, 2011 | Vol. 89 Issue 24 | p. 10) University of Puerto Rico chemistry professor Ingrid Montes will receive the society's 2012 volunteer service award. Science & Technology Concentrates (June 13, 2011 | Vol. 89 Issue 24 | p. 33) Sticky Tape Sorts Nanotubes Nanoscientists unveil sticky polymer films that selectively separate metallic and semiconducting SWNTs New Elements Make It To The Periodic Table Elements 114 and 116 are now officially on the periodic table after an international committee gives its stamp of approval Bicyclic Diphosphines Flip Inside Out Chemists identify a rare case of isomerism in which a cagelike macromolecule turns itself inside out Small Peptide Could Heal Broken Hearts Thymosin 4 prods undifferentiated heart cells to morph into cardiomyocytes that could help repair tissue damage Single Layer Marks Air-Water Interface Researchers find that the transition to bulk water is remarkably thin, occurring within one molecular layer June 6, 2011 BPA Debate (June 6, 2011 | Vol. 89 Issue 23 | pp. 13-22) Researchers disagree about potential toxicity of the estrogen mimic bisphenol A. New Base On The Block (Member Content) (June 6, 2011 | Vol. 89 Issue 23 | pp. 40-41) Discovery of a modified cytosine in DNA with possible roles from cancer to cognition triggers a new research field. Mass Spec Imaging Goes To Court (Member Content) (June 6, 2011 | Vol. 89 Issue 23 | p. 42) Forensic document analysis with SIMS clearly shows which ink is on top. Arsenic Bacterium Debate Continues (June 6, 2011 | Vol. 89 Issue 23 | p. 7) Research: Science publishes rebuttals to a sensational claim about DNA biochemistry. Compound Prevents Neurodegeneration (June 6, 2011 | Vol. 89 Issue 23 | p. 8) Neurochemistry: Small molecule alleviates Alzheimer's, Huntington's symptoms in animals. More Science, Online Only (June 6, 2011 | Vol. 89 Issue 23 | p. 10) ACS News: Synthetic biology, polymer science will be the focus of two new ACS journals on the web. Trio Receives Wolf Chemistry Prize (June 6, 2011 | Vol. 89 Issue 23 | p. 10) Honors: Three professors in the chemical sciences are cited for their work on organic materials. A New Look At Protein Misfolding (June 6, 2011 | Vol. 89 Issue 23 | p. 11) Protein chemistry: Fluorescence method reveals details of disease-related process. Science & Technology Concentrates (June 6, 2011 | Vol. 89 Issue 23 | pp. 38-39) Cyclic Gradient Copolymers Debut This new class of copolymer starts with one monomer, gradually switches to another, then forms a closed loop Biomarker Associations Often Overestimated Most reported biomarkers proposed to diagnose disease or monitor treatment don’t live up to their initial billing Combo Method Yields Chondroitin Sulfate A microbiological-chemical approach is the first prep-scale synthesis of the naturally sourced osteoarthritis drug Atmospheric Mercury Is On The Decline Global mercury concentrations have unexpected decreased by as much as 38% during the past 15 years Another Ultrafast Microscopy Method Laser-driven method adds femtosecond time resolution to scanning electron microscopy’s spatial resolution Cross-Couplings Go With The Flow MIT researchers have developed an efficient multistep Suzuki-Miyaura reaction in a continuous-flow microreactor system Vaccine Candidate For C. difficile A complex hexasaccharide found in the pathogen’s cell wall is the basis of a possible life-saving vaccine Volatile Odorants Confuse Mosquitoes Brief exposure to a blend of molecules knocks the insect’s CO2-sensing out of whack, hinting at a possible new control method May 30, 2011 Woodward's Unfinished Work (Member Content) (May 30, 2011 | Vol. 89 Issue 22 | pp. 46-49) More than 30 years after his death, a selection of R. B. Woodward's notes on conducting materials is published. Synthesis Sees Inflationary Push (Member Content) (May 30, 2011 | Vol. 89 Issue 22 | pp. 50-52) Historical analysis of inflated yield and purity data in organic synthesis papers points to pressure to produce high-impact results. Improving Vaccines Aimed At Cancer (Member Content) (May 30, 2011 | Vol. 89 Issue 22 | pp. 53-57) Scientists use various ways to strengthen immune response to carbohydrate cancer antigens. Ubiquitins In Four-Part Harmony (May 30, 2011 | Vol. 89 Issue 22 | p. 7) Biomacromolecular Synthesis: Tetraubiquitin is the longest protein made chemically. Watery Magma From The Moon (May 30, 2011 | Vol. 89 Issue 22 | p. 10) Moon's Origin: High levels of water found in ancient lunar magma bubbles add twist to giant-impact theory. Science & Technology Concentrates (May 30, 2011 | Vol. 89 Issue 22 | pp. 44-45) Sniffing Out Black-Currant Structures Microwave spectroscopy and quantum chemistry provide gas-phase information on fragrant molecules. Organic Layer Smooths Dielectric Films Insulating layer in nanoelectronic devices benefits from an organic undercoat. Microbe’s Protein Structure Elucidated Study finds that arrangement of heme groups forms electron shuttle. Pulling Out Protein Complexes Antibody-based method isolates proteins from complexes for single-molecule analysis. Molecular Constraint Inhibits Peptide Aggregation Reversible modification enhances water solubility and simplifies synthesis. Peptide-Nanotube Assemblies Create Superstructures Specially designed biomolecules coil around nanotubes and guide supramolecular ordering. Key Catalyst Support Parameters Identified Maximum surface area coupled with 3D interconnectivity enhances catalytic activity and selectivity. Scorpion Venom Unfriendly To Fungi Peptides and other compounds from stinging critter exhibit fungicidal properties. May 23, 2011 Using The Force On Cancer (Member Content) (May 23, 2011 | Vol. 89 Issue 21 | pp. 34-36) Researchers probe the mechanics of tumor cells with atomic force microscopy and explore the technique as a diagnostic tool. C&EN Talks With Susan Marie Frontczak (May 23, 2011 | Vol. 89 Issue 21 | p. 37) Scientist-storyteller draws career and outreach lessons from Marie Curie's life, and her own. Fire Retardants In Baby Products May Pose Health Risks (May 23, 2011 | Vol. 89 Issue 21 | p. 7) Toxic Substances: Infants may be exposed to high levels of a toxic fire retardant. Graphene Via Electrochemistry (May 23, 2011 | Vol. 89 Issue 21 | p. 8) Materials: Process that damages batteries yields desirable form of carbon. A New Detector For Endotoxin (May 23, 2011 | Vol. 89 Issue 21 | p. 10) Sensors: At low levels, bacterial lipid causes visible reordering of liquid crystals. Reshaping Salt (May 23, 2011 | Vol. 89 Issue 21 | p. 10) Sodium chloride deviates from usual cubic crystal form under certain conditions. Science & Technology Concentrates (May 23, 2011 | Vol. 89 Issue 21 | pp. 32-33) Safer Synthesis Of Fluorophosphate Crystals Method for making analogs of metal oxides avoids hydrofluoric acid Biomass Burning Generates Isocyanic Acid Mass spectrometry method detects part-per-trillion levels of inflammation agent C-C Protein Crosslink Creates Substrate Pocket Novel structure found in microscopic algae protein Weak Acids Irritate Ion Channel Mechanism identifies action of acetic acid on cell membrane Metathesis Catalyst Catches A Few More Zs Revised version of ruthenium catalyst improves selectivity for Z alkenes in olefin metathesis reactions Spotting Clotting Detection strategy for blood clot regulator combines oligonucleotide, fluorescent probe and reversible inhibitor Molecules Vanish In Nanotubes Molecular dipoles induce mirror-image nanotube dipole that screen molecules from IR light Natural Halocarbon In Boar Meat Fungi chemical could aid understanding of halogenated pollutants May 16, 2011 Learning To Love The Cloud (Member Content) (May 16, 2011 | Vol. 89 Issue 20 | pp. 34-35) Cloud computing could provide faster and cheaper solutions to some problems, but chemists remain wary. A Giant Leap For Cell Analysis (Member Content) (May 16, 2011 | Vol. 89 Issue 20 | p. 36) Mass cytometry boosts the number of single-cell parameters that can be measured simultaneously. Methane Fouls Well Water (May 16, 2011 | Vol. 89 Issue 20 | p. 5) Environment: Study confirms link to gas drilling, as a new panel is formed to study public safety. Wiring A Single-Molecule Circuit (May 16, 2011 | Vol. 89 Issue 20 | p. 7) Electronics: Researchers link polymer nanowires to single molecules. Unnatural Backbone Mimics -Helix (May 16, 2011 | Vol. 89 Issue 20 | p. 8) Peptide Chemistry: -Amino acid stabilizes structural copycat. Waugh, Marks Win Big Prizes (May 16, 2011 | Vol. 89 Issue 20 | p. 9) Honors: John Waugh takes Welch Award, Tobin Marks nabs Dreyfus Prize. Science & Technology Concentrates (May 16, 2011 | Vol. 89 Issue 20 | pp. 32-33) Big Squeeze Clears Out Protein Garbage A mega cellular enzymatic machine undergoes a large conformational change to spit out its waste Chemical Fix For Rare Muscular Dystrophy Flaw Compound restores key missing protein to cells taken from a muscular dystrophy patient Methane Yields To Supercritical CO2 Carbon dioxide solvent, coupled with a silver catalyst, provides the right conditions for a successful C–H functionalization Deep-Sea Vents Dispense Nutritious Pyrite Nanoparticles Iron from pyrite (FeS2) particles delivered over long distances helps feed oceanic bacteria and plankton Telomerase Pseudoknots Needed For Catalysis The structural feature is determined to be necessary for the RNA portion of this enzyme to be catalytically active Dust Removes Ozone From Indoor Air Squalene and cholesterol, as major components in dust, react with ozone to help remediate household air Cisplatin To Blame For Zinc Deficiency When the anticancer drug binds albumin, it blocks the protein’s zinc binding site, causing the chemotherapy side effect Supercapacitors Made From Super Carbon Carbon material with a 3-D porous structure has exceptional surface area and electrical properties May 9, 2011 The Next Generation In Genome Sequencing (May 9, 2011 | Vol. 89 Issue 19 | pp. 17-21) Advances in technology create new challenges in data analysis. Saving Space Suits (May 9, 2011 | Vol. 89 Issue 19 | pp. 40-41) Conservators try to stop the degradation of NASA's outer space outfits. With Photo Gallery Making Connections At NOBCChE (May 9, 2011 | Vol. 89 Issue 19 | pp. 42-43) Two students seek answers to career questions at annual meeting of black chemists and chemical engineers. With Photo Gallery NOBCChE's 2011 Science Bowl And Fair (May 9, 2011 | Vol. 89 Issue 19 | Web Exclusive) Middle and high school students from Michigan dominate competitions at this year's meeting. With Photo Gallery And Video Jolting The Diels-Alderase Hunt (May 9, 2011 | Vol. 89 Issue 19 | p. 11) Biochemistry: Newly discovered enzyme could help chemists determine whether Diels-Alder reaction occurs in nature. Porous Polymer Captures CO2 (May 9, 2011 | Vol. 89 Issue 19 | p. 14) Materials: Tetrazole groups in new material selectively snag greenhouse gas. Academy Elects New Members (May 9, 2011 | Vol. 89 Issue 19 | p. 14) Honors: Ninety scientists join the ranks of the National Academy of Sciences. Science & Technology Concentrates (May 9, 2011 | Vol. 89 Issue 19 | pp. 38-39) Tuning In To Microbe Chatter Method detects protein receptors involved in detecting chemical words bacteria use to communicate Custom Doped Thermoelectrics Material with tailored electronic structure exhibits record-setting thermoelectric effect Rock Slime Harbors Endocrine Disrupters Water Pollution: Slippery scum on stream beds might accumulate hormone mimics A Clearer Picture Of Cell Secretion Scientists combine electrochemical and optical measurements to study exocytosis Dendrimer Treats Joint Inflammation Highly branched polymer relieves rheumatoid arthritis symptoms in mice Sweetening The Search For Breast Cancer Biomarkers Clinical Diagnostics: New method could help reveal cancer-related changes in protein sugar modifications Inorganic Caps Give Nanocrystals A Boost Replacing organic ligands with inorganic ones selectively boosts electron transport Ketenes Finally Give In To Cycloadditions Compounds finally join list of unsaturated substrates used in transition-metal-catalyzed cycloadditions May 2, 2011 Storm Over Silicones (May 2, 2011 | Vol. 89 Issue 18 | pp. 10-13) Some cosmetic ingredient makers defend cyclic methylsiloxanes as competitors tout substitutes. Capturing CO2 (Member Content) (May 2, 2011 | Vol. 89 Issue 18 | pp. 30-32) ACS Meeting News: Custom chemistry is yielding a broad selection of novel sorbents for the greenhouse gas. Detecting Misfolded Protein Aggregates (May 2, 2011 | Vol. 89 Issue 18 | p. 5) Biochemistry: Assay might aid early disease diagnosis. Microrockets Take Off (May 2, 2011 | Vol. 89 Issue 18 | p. 6) Diagnostics: Tiny motors capture cancer cells and DNA from biological fluids. Friedel-Crafts Takes A New Gig (May 2, 2011 | Vol. 89 Issue 18 | p. 9) Organic Synthesis: Silane-fueled, proton-catalyzed strategy extends carbon-carbon coupling. Doctoral Program Rankings, Take Two (May 2, 2011 | Vol. 89 Issue 18 | p. 9) Graduate Schools: National Research Council releases revised Ph.D. program assessment. Science & Technology Concentrates (May 2, 2011 | Vol. 89 Issue 18 | pp. 28-29) Iceland Ash Did Pose Hazard Analysis of particles supports aviation officials’ decision to ground flights after last year’s volcanic eruption Extraction Captures Elusive Metabolites In vivo solid-phase microextraction uses a hypodermic fiber to obtain a more complete picture of the metabolome Going Anhydrous Modifies TEMPO-H A water-free version of the popular reagent for supplying hydrogen atoms is more stable and leads to modified reactivity Nanotubes Improve Transistor Performance Low-voltage transistors incorporating carbon nanotubes could make large OLED display screens a practical possibility Nanoparticles Stymie Peptide Aggregation Although some nanoparticles trigger amyloid- peptide aggregation, scientists find smaller ones can inhibit the process Defluorinase Reaction Mechanism Mapped Out Biochemists capture the first detailed molecular view of the biocatalytic activity of rare enzymes that break C–F bonds Sweet Treat Leads To Stinky Predation Moth caterpillars that munch sugary leaves produce poop that invites predator ants to come have a feast Pairing Drugs Kills Pathogens Nonantibiotics such as Imodium and Antabuse can soup up the potency of weak antibiotics such as minocycline April 25, 2011 Building Better Bacteria(Member Content) (Apr 25, 2011 | Vol. 89 Issue 17 | pp. 34-36) Synthetic biologists turn to a microbe named Shewie to 'wire' microorganisms for fuel production, energy storage. Challenges To Water Reuse (Member Content) (Apr 25, 2011 | Vol. 89 Issue 17 | pp. 38-39) ACS Meeting News: Projects to recycle wastewater face not only scientific but also economic and social hurdles. Mending With Light (Apr 25, 2011 | Vol. 89 Issue 17 | p. 8) Materials Chemistry: Light prompts metallosupramolecular polymers to repair themselves. Nabbing Nitrogen (Apr 25, 2011 | Vol. 89 Issue 17 | p. 10) Organic Synthesis: Metal-free method adds amines to alkanes. Nobel Laureate William Lipscomb Dies At 91 (Apr 25, 2011 | Vol. 89 Issue 17 | p. 10) Obituary: Acclaimed Harvard University chemist was known for his dedication to science, other wide ranging interests. Chopping Up Lignin (Apr 25, 2011 | Vol. 89 Issue 17 | p. 11) Organic Chemistry: Catalyst selectively cleaves key bond in models of complex plant polymer. Science & Technology Concentrates (Apr 25, 2011 | Vol. 89 Issue 17 | p. 33) Imaging Plant Imprints Imprinting plant material on a porous Teflon surface allows researchers to use mass spectrometry to image secondary metabolites in soft plant tissues. Impeding Cisplatin’s Power Finding could guide changes that make anticancer drug more potent with fewer side effects Extra Chlorophyll Helps Bacteria Photosynthesize Eighth and previously unknown bacteriochlorophyll may be missing link to help scientists understand how bacteria turn sunlight into chemical energy DNA Scribes Seen Live Single-molecule fluorescence unveils rate-determining step for transcription Platinum-Free Fuel-Cell Catalyst Polyaniline, iron, and cobalt combine to make cheap fuel-cell cathode catalyst April 18, 2011 Unveiling Drug Candidates (Member Content) (Apr 18, 2011 | Vol. 89 Issue 16 | pp. 37-41) ACS Meeting News: Medicinal chemists reveal potential drugs for HIV, Alzheimer's, diabetes, and irritable bowel syndrome. Where Are They Now? Revisiting Disclosures From Years Past (Member Content) (Apr 18, 2011 | Vol. 89 Issue 16 | p. 38) An Alternative Methylation Route (Member Content) (Apr 18, 2011 | Vol. 89 Issue 16 | pp. 42-43) ACS Meeting News: Details of bacterial enzymes' unusual methylation step may help fight antibiotic resistance. SciFinder's New Tool (Member Content) (Apr 18, 2011 | Vol. 89 Issue 16 | p. 45) SciPlanner lets chemists visually interact with Chemical Abstracts Service data. Picking Up The Pace Of Evolution (Apr 18, 2011 | Vol. 89 Issue 16 | p. 7) Molecular Biology: Method speeds lab-based molecular evolution. Heterogeneous Tandem Catalysis (Apr 18, 2011 | Vol. 89 Issue 16 | p. 9) Catalysis: Nanostructured layered material performs multistep reaction. Chlorination Improves Organic Electronics (Apr 18, 2011 | Vol. 89 Issue 16 | p. 10) Materials: Treatment could simplify manufacturing, reduce costs. Science & Technology Concentrates (Apr 18, 2011 | Vol. 89 Issue 16 | pp. 35-36) Meth Vaccine Revamped New methamphetamine analogs elicit antibodies to squelch the addictive drug’s activity Rechecked Meteorite Yields New Mineral Tiny deposits of wassonite, a TiS mineral, provide more details on the formation of the solar system Silicon Radicals Double Up Using carbon analogs as a guide, a Japanese team has synthesized the first stable silicon diradical species Peptide Denies Cell Entry To Ebola Virus With a newly designed peptide, scientists have developed a way to inhibit the deadly virus Ion Migration In Electrodes Revealed Fluorosulfate materials reveal differences in Na+ and Li+ movement, a finding that could improve rechargeable batteries Shorter Route Refines Total Synthesis Of Anticancer Agent A new preparation of the natural product englerin A requires6 fewer steps and has a better overall yield Green-Lighting Boron Carbide A new pyrotechnic material burns green in color, is greener for the planet, and is easy on the greenbacks Cell Antennas Tune In To Chemical Signals Thin, fingerlike protrusions are essential in aiding cells to trace molecular messages they need for development April 11, 2011 PI3K At The Clinical Crossroads (Apr 11, 2011 | Vol. 89 Issue 15 | pp. 15-19) After a frenzy to develop better and more selective PI3K inhibitors, companies now must figure out how to use them in cancer patients. Retooling A Bacterial Biofuel Factory (Apr 11, 2011 | Vol. 89 Issue 15 | pp. 36-37) ACS Meeting News: Gene swaps tweak kinetics and equilibrium to increase output. Probing Nanotube Photochemical Properties (Apr 11, 2011 | Vol. 89 Issue 15 | p. 39) ACS Meeting News: Surprising results question key assumptions about effectiveness of nanotubes in solar cells. Chiral Route To Key Anticancer Agent (Member Content) (Apr 11, 2011 | Vol. 89 Issue 15 | p. 41) First enantioselective synthesis of nutlin-3 could lead to analogs for cancer studies. Carbenes Map Protein Surface (Apr 11, 2011 | Vol. 89 Issue 15 | p. 10) Structural Biology: Highly reactive species nonselectively label amino acids. Safer Carbonylations (Apr 11, 2011 | Vol. 89 Issue 15 | p. 11) Synthesis: New approach could ease small-scale carbon monoxide reactions. New Route To Graphene Devices (Apr 11, 2011 | Vol. 89 Issue 15 | p. 12) Nanoelectronics: Procedure draws on industry-compatible methods and materials. Science & Technology Concentrates (Member Content) (Apr 11, 2011 | Vol. 89 Issue 15 | pp. 34-35) Genetic Tag For Electron Microscopy Imaging: Biobased label enables scientists to pinpoint proteins in cells, tissues Record Loss In Arctic’s Ozone Layer This year’s 40% decline has resulted from a combination of lingering CFCs and a particularly cold winter Promising Drug Lead For Filariasis Natural product targets an important enzyme that affects the viability of a worm that causes the disease Ancient Catalyst Uses Modern Tricks Paleochemistry: Resurrected enzyme reveals sophisticated mechanism of action Nanoparticles Impact Pregnancy In Mice Study provides more detailed information about the size and chemistry of nanoparticles that can lead to problems Water Serves As A Protein Glue Adhesive water bridges help stabilize hydrophilic protein-protein interactions and guide the molecules together Origin-Of-Life Implications For Synthetic RNA Scientists develop RNAs that synthesize new RNAs or can assemble a new RNA enzyme, a step short of RNA self-replication Comets’ And Meteorites’ Carbonaceous Chemical Roots Formaldehyde appears to be a common source for polymeric materials in comets, chondrites, and interplanetary dust April 4, 2011 Pittcon 2011 (Apr 4, 2011 | Vol. 89 Issue 14 | pp. 37-40, 41-42, 43-46) Year of recovery brings increases in conference attendance, mergers and acquisitions, and instrumentation sales. Blue Whodunit (Apr 4, 2011 | Vol. 89 Issue 14 | pp. 32-33) Artifact-staining dye structures revealed, but case far from closed. Chemists Gather In The Golden State (Apr 4, 2011 | Vol. 89 Issue 14 | p. 9) ACS Meeting News: Natural resources chemistry was Anaheim meeting theme. Probing Cancer Drug Resistance (Apr 4, 2011 | Vol. 89 Issue 14 | p. 10) ACS Meeting News: Atomic force microscopy could yield new insights from observed changes in treated cancer cells. Polymer Synthesis On Command (Apr 4, 2011 | Vol. 89 Issue 14 | p. 10) ACS Meeting News: Applied voltage modulates polymerization with precise control. A New Twist On Aqua Regia (Apr 4, 2011 | Vol. 89 Issue 14 | p. 11) ACS Meeting News: Powerful organic-based systems dissolve noble metals under mild conditions. Prudent Practices Updated (Apr 4, 2011 | Vol. 89 Issue 14 | p. 13) ACS Meeting News: Manual for safe handling, storage, and disposal of chemicals receives a makeover. Single-Molecule Potentiometers (Apr 4, 2011 | Vol. 89 Issue 14 | p. 13) ACS Meeting News: As electrode moves along molecular wire, conductance of single-molecule device changes. Testing And Treating For Chromium (Member Content) (Apr 4, 2011 | Vol. 89 Issue 14 | pp. 34-35) As regulators consider tightening limits on Cr (VI) in drinking water, analysis and treatment technology may limit how low they can go. Science & Technology Concentrates (Member Content) This week's selections are from the ACS national meeting, which took place on March 27–31 in Anaheim, Calif. (Apr 4, 2011 | Vol. 89 Issue 14 | pp. 36-37) Blocking Bitterness ACS Meeting News: Two compounds eliminate bitter aftertaste Plastics Created From Yeast-Made Monomers ACS Meeting News: With genetic engineering, chemists coax yeast into making -hydroxy fatty acids for producing degradable polymers Polymer Vision ACS Meeting News: Chemists aim to create waterproof coatings that protect retinal implants without causing scarring Spreading Antibiotic Resistance During Water Treatment ACS Meeting News: Heavy metals promote the spread of antibiotic resistance in treatment plant microbes Gold Carbonyls Proliferate ACS Meeting News: Rare complexes could provide new leads for gold-mediated chemical processes Molecular Megaphone Made to Order ACS Meeting News: Two-component strategy translates trace analytes into a colored readout SERS Substrates Made With Pocket Change ACS Meeting News: Metal substrates needed for Raman spectroscopy technique can be made with everyday objects––even coins Collaborative Study Yields TB Drug Leads ACS Meeting News: Scientists combine sets of information to identify small molecules that defeat the tuberculosis bacterium in lab studies March 28, 2011 Scientist-Diplomat Extraordinaire (Mar 28, 2011 | Vol. 89 Issue 13 | pp. 12-16) Straddling the U.S. and Middle East, Priestley Medalist Ahmed H. Zewail thrives at the interface of science, culture, and international affairs. The Angel's Wing Mystery (Member Content) (Mar 28, 2011 | Vol. 89 Issue 13 | pp. 38-39) An unstable amino acid may have something to do with deadly mushroom poisoning. Reel Science: 'Cool It' (Mar 28, 2011 | Vol. 89 Issue 13 | p. 40) Bjørn Lomborg sheds new light on the climate-change debate. Single-Molecule Magnets Evolve (Mar 28, 2011 | Vol. 89 Issue 13 | p. 8) Organometallics: Erbium complex displays new magnetic features that could lead to practical uses. Faster, Better Infrared Imaging (Mar 28, 2011 | Vol. 89 Issue 13 | p. 8) Analytical Chemistry: Multiple synchrotron beams improve speed and resolution of IR chemical imaging. Rigging Cross-Metathesis (Mar 28, 2011 | Vol. 89 Issue 13 | p. 9) Organic Synthesis: Molybdenum catalyst generates less stable Z olefin. Porphysomes Do It All (Mar 28, 2011 | Vol. 89 Issue 13 | p. 10) Biophotonics: Lipid-porphyrin nanovesicles offer both cancer diagnosis and treatment . Science & Technology Concentrates (Member Content) (Mar 28, 2011 | Vol. 89 Issue 13 | pp. 36-37) Origin-of-Life Surprises Reexamination of some 50-year-old vials from Stanley Miller’s experiments turns up new results. Cancer: A Protein Aggregation Disease Misfolded and aggregated proteins––longtime hallmarks of brain disorders––also appear to play a role in cancer. Metallic Aluminum Forms Tetrahedrons Electron distribution maps provide a better explanation for some of bulk aluminum’s properties. Stressing Strengthens Nanocomposites Polymer-nanotube composites exhibit a property characteristic of bone and biomechanical tissues. Some Mouth Microbes Battle Dental Plaque Besides bacteria that cause cavities and gum disease, the mouth is home to bacteria that produce tooth-friendly enzymes. Press-And-Go Fingerprinting Polyurethane-fluorescein nanofiber mats lift and quickly image latent fingerprints from different types of surfaces. A Salty Energy Source A newly devised battery can store the entropic energy dissipated as freshwater and saltwater mix. Carboryne Insertion Goes Two Ways Reactive boron-carbon clusters have two resonance forms that exhibit significantly different reactivity patterns. March 21, 2011 Synthetic Strollers (Member Content) (Mar 21, 2011 | Vol. 89 Issue 12 | pp. 43-45) Inspired by nature, scientists build walking molecules that stay on track. Behind Olive Oil's Bite (Member Content) (Mar 21, 2011 | Vol. 89 Issue 12 | pp. 46-47) Lone protein's locale explains distinctive sting. Molecular Machine's Workings Visualized (Mar 21, 2011 | Vol. 89 Issue 12 | pp. 48-49) Study provides real-time glimpse of assembly of single spliceosomes. (With Video) Amphotericin B Mystery Solved (Member Content) (Mar 21, 2011 | Vol. 89 Issue 12 | p. 51) Decades-long question about antifungal agent's mechanism is answered. Monitoring The Heart (Mar 21, 2011 | Vol. 89 Issue 12 | p. 53) Flexible sensors on balloon catheters boost data gathering during procedures. Japan Fights For Its Rising Sun (Mar 21, 2011 | Vol. 89 Issue 12 | pp. 8-9) Natural Disaster: Frontline reports from the country's chemical enterprise underscore the scope of the tragedy, hopes for recovery. 'Good' Cholesterol Comes Into Focus (Mar 21, 2011 | Vol. 89 Issue 12 | p. 10) Heart Disease: Cross-linking mass spectrometry gives clues to native structure of high-density lipoprotein. A New Heartbeat Helper (Mar 21, 2011 | Vol. 89 Issue 12 | p. 12) Drug Discovery: Small molecule powers cardiac myosin to counteract heart failure. Sperm's Come-Hither Channel (Mar 21, 2011 | Vol. 89 Issue 12 | p. 12) Reproductive Biology: Membrane protein relays steroid hormone signal. Science & Technology Concentrates (Member Content) (Mar 21, 2011 | Vol. 89 Issue 12 | pp. 41-42) Plant Sex Requires D-Serine D-serine signaling helps guide pollen tube cells to their ovule objective Atomic Emission Spectrometer Shrinks Lightweight, inexpensive instrument uses wire from a light bulb Building Boron-Containing Polyphenylenes Ring-opening reaction provides a better route to oligomer building blocks for making optoelectronic materials Better Way To Organic Photovoltaics All-carbon composite solar cell made from organic components suspended in water Catalytic, Enantioselective Use of Organolithiums Methodology opens the door to popular reagents’ use for making chiral molecules Magnetic Field Triggers Liposome Release Confocal laser scanning microscopy used to spy on lipid vesicles as they release their payload in a low-frequency magnetic field Regenerating Hydrogen-Fuel Storage Material Hydrazine treatment restores spent polyborazylene to ammonia borane fuel Fullerenes In A Box Porphyrin cage sequesters massive aromatic guests March 14, 2011 From Picture To Pill (Mar 14, 2011 | Vol. 89 Issue 11 | pp. 15-21) Debut of G-protein-coupled receptors will bolster drugmakers' tool kits. Inflammation Stokes Cancer (Member Content) (Mar 14, 2011 | Vol. 89 Issue 11 | pp. 40-43) When it goes awry, this defense mechanism can contribute to all stages of cancer progression. Moving Up The Food Chain (Member Content) (Mar 14, 2011 | Vol. 89 Issue 11 | pp. 44-46) As they transfer to higher organisms in a food web, nanomaterials can increase in concentration, new studies show. Plastics Release Estrogenic Chemicals (Mar 14, 2011 | Vol. 89 Issue 11 | p. 48) Study finds that even BPA-free products leach potentially problematic compounds. Nanodiamonds Fight Cancer (Mar 14, 2011 | Vol. 89 Issue 11 | p. 10) Chemotherapy: Faceted nanomaterials deliver drugs to tumor cells. Oil Spill's Air Effects Probed (Mar 14, 2011 | Vol. 89 Issue 11 | p. 11) Deepwater Horizon: Aircraft data show how accident's emissions affected Gulf of Mexico atmosphere. Poised To React (Mar 14, 2011 | Vol. 89 Issue 11 | p. 12) Nanoscience: Tethering molecules to gold surface forces reaction. First Hit For A Cancer Target (Mar 14, 2011 | Vol. 89 Issue 11 | p. 13) Drug Discovery: Academic collaboration leads to nanomolar inhibitor for phosphatase methylesterase-1. Science & Technology Concentrates (Member Content) (Mar 14, 2011 | Vol. 89 Issue 11 | pp. 38-39) Fluoride Blocks For Enzyme Blocked active site allows scientists to visualize enzyme-inhibitor complexes that couldn’t be seen before Study Suggests New Criteria For Electrocatalysts Theoretical findings on O2 reduction energetics should help the selection of better-performing fuel-cell catalysts Rhodium-Catalyzed Reaction Pinned Down Calculations suggest the C–H activation/Cope rearrangement combo can be customized to deliver multiple chiral products Mycobacteria Have A System For Acquiring Iron From Heme In addition to using iron-chelating siderophores, the tuberculosis microbe uses a heme-binding protein to grab iron … And Can Now Enter The Spotlight For In-Cell Detection Scientists unveil the first molecular probe for live, in-cell detection of the pathogenic bacterium Nanotube Confinement Boosts Catalysis Platinum nanoparticles inside carbon nanotubes are effective catalysts for asymmetric hydrogenations Laser-Induced Shock Wave Chromatography Proteins and quantum dots can be separated for analysis by the impact induced by a laser shock wave Forster Reaction Delivers Generic Drug A novel synthetic route to make a hyperparathyroidism drug uses a century-old, unexplored method March 7, 2011 Battling The Bedbug Epidemic (Mar 7, 2011 | Vol. 89 Issue 10 | pp. 13-18) Chemical controls, government action, and personal vigilance are all required to tame the outbreak. Chemistry Unlocks Ancient Secrets (Member Content) (Mar 7, 2011 | Vol. 89 Issue 10 | pp. 44-47) Cutting-edge analytical methods decipher molecular clues buried in age-old artifacts. Calcium's Awakening (Member Content) (Mar 7, 2011 | Vol. 89 Issue 10 | pp. 49-51) After sitting interminably in magnesium's shadow, the alkaline-earth metal's chemistry is coming alive. 'Shaving' Graphene (Mar 7, 2011 | Vol. 89 Issue 10 | p. 8) Nanoscience: Zinc treatment chemically peels off layers of graphene. Organocatalysis Expands (Mar 7, 2011 | Vol. 89 Issue 10 | p. 9) Synthesis: Method directly yields -functionalized aldehydes. Quake Shakes New Zealand Chemistry (Mar 7, 2011 | Vol. 89 Issue 10 | p. 10) Natural Disaster: Upheaval closes Christchurch area universities. Science & Technology Concentrates (Member Content) (Mar 7, 2011 | Vol. 89 Issue 10 | pp. 42-43) Molecular Machine Wrap A helical molecule that can wrap and unwrap itself around a dumbbell-shaped molecule functions as a molecular shuttle ‘Ethical’ Stem Cell Abnormalities Could Hinder Research New findings reveal that induced pluripotent stem cells can have problematic mutations Fluoride Sensor Also Fluorinates A sulfonium borane complex that traps fluoride ions can turn around and use them in substitution reactions Stealth Bacteria Fighters Have Golden Stability Chemists have designed gold-stabilized liposomes to selectively deliver antimicrobial agents to sites of infection Ammonia-Emitting Meteorite Hints At Life’s Origins Evidence from an Antarctic meteorite makes a case for outer-space delivery of chemicals essential for life Balancing Act Reduces Peptide Aggregation Scientists modulate molecular aggregation by balancing hydrophobicity and electrostatic repulsion Chemical Weapon For Plants Unsheathed The war between plants and infectious microbes uncovers sulforaphane as a natural plant-defense chemical Mucus Proteins Aid Hydrophobic Pollutants Glycoproteins in mucus may increase the toxicity of polycyclic aromatic hydrocarbons by helping them enter cells February 28, 2011 Navigating Nagoya (Member Content) (Feb 28, 2011 | Vol. 89 Issue 09 | pp. 50-51) Natural product hunters prepare to adapt to new biodiversity treaty. The Case Of The Missing Xenon (Feb 28, 2011 | Vol. 89 Issue 09 | p. 10) Noble Gases: First XeO2 synthesis could provide the final clue to one of Earth's geochemical mysteries. Big Enzyme Takes On Tiny Target (Feb 28, 2011 | Vol. 89 Issue 09 | p. 11) Catalysis: Modifying a huge active site enables conversion of methane to methanol. Science & Technology Concentrates (Member Content) (Feb 28, 2011 | Vol. 89 Issue 09 | pp. 48-49) Sequestered Antibiotics Shuttling drugs away from their intended targets can sometimes transform them into good antimicrobials. A Revised Picture Of Deep-Earth Sulfur Under extreme conditions, sulfur may exist as S3-, rather than the presumed sulfide and sulfate species. Picking Prion Infectivity Apart New research suggests that infectious protein misfolding and Prion diseases’ neurological toxicity are independent processes. Iron(V) Nitride Mimics Nitrogenase Activity Chemists have isolated a rare FeºN complex and show that it readily produces ammonia. Catalytic Methanol Coupling Achieved An iridium complex catalyzes the direct C–H functionalization of methanol, a first for the single-carbon compound. Fish Poop Establishes A Geologic Record Scientists find that the aquatic vertebrates generate a large portion of the carbonate mud that deposits on the ocean floor. Palladium-Allyl Bridges Snatch CO2 Unusual double-bridging complexes reveal their ability to insert CO2 and form carboxylates. Peptide Induces Hair Regrowth In Mice Astressin B helps genetically altered mice to regain skin pigmentation and regrow nearly all their hair. February 21, 2011 China's Journals Embrace English (Member Content) (Feb 21, 2011 | Vol. 89 Issue 08 | pp. 35-38) Number and influence of English-language chemistry publications from China climb. Making Solar Panels Greener (Feb 21, 2011 | Vol. 89 Issue 08 | pp. 37-38) Producing photovoltaic panels more sustainably will require reducing energy consumption, toxic substances. Dynein's Motor Revealed (Feb 21, 2011 | Vol. 89 Issue 08 | p. 8) Structural Biology: Researchers solve first crystal structure of long-elusive molecular motor. Alkenes From Diazo Compounds (Feb 21, 2011 | Vol. 89 Issue 08 | p. 10) Organic Chemistry: Versatile nitrogen-containing reagents have surprising reactivity. Connecting Bacteria (Feb 21, 2011 | Vol. 89 Issue 08 | p. 11) Microbiology: Nanotube links between cells foster exchange of genes and proteins. Science & Technology Concentrates (Member Content) (Feb 21, 2011 | Vol. 89 Issue 08 | pp. 33-34) Silkworms’ Colorful Diet Slipping rhodamine dyes in with mulberry leaves is a potential green, low-cost method for making colored silks. Mechanistic Study Boosts Knowledge Of Radical Polymerization Cleavage of alkyl halide initiators proceeds via a concerted process rather than a stepwise mechanism. RNA Recycling As An Antibiotic Plan Stopping degradation of outdated RNA helps staph-infected mice survive. Epigenetic Clues To Arsenic Toxicity Newly identified tumor-suppressor genes could help unravel how long-term arsenic exposure leads to diseases. Real-Time Mass Spec Aids Cancer Surgery Chemists combine mass spectrometry with laser surgery to quickly identify tumor tissue boundaries. DNA Puts New Spin On Electron Transfer Tightly packed DNA monolayers can filter electron spins for possible use in electronics Long-Lived Oxygen Species Are Key To Ozone Reactions Atmospheric ozone reacts with polycyclic aromatic hydrocarbons in aerosol particles through a multistep mechanism. Microprobe Captures Dual Neuron Signals A new device allows scientists to make parallel optical and electrical measurements of individual neurons in live lab rats. February 14, 2011 Race To The Pump (Feb 14, 2011 | Vol. 89 Issue 07 | pp. 11-17) Biofuel technologies vie to provide a sustainable supply of transportation fuels. C&EN Talks With Bruce Dale (Feb 14, 2011 | Vol. 89 Issue 07 | WEB EXCLUSIVE) Michigan State chemical engineer takes a critical look at the pluses and minuses of biofuels. Soft Robots Get A Grip (Member Content) (Feb 14, 2011 | Vol. 89 Issue 07 | pp. 36-37) Materials innovations advance robotics. C&EN Talks With Bruce Ames (Member Content) (Feb 14, 2011 | Vol. 89 Issue 07 | p. 38) Developer of test for carcinogens now champions micronutrients for preventing disease. Organic Crystals Light Up (Feb 14, 2011 | Vol. 89 Issue 07 | p. 6) Materials: Compounds use halogen bonds for metal-free phosphorescence. Light Turns On Caged Enzyme (Feb 14, 2011 | Vol. 89 Issue 07 | p. 7) Biology: Illuminating a kinase bearing unnatural lysine reveals cell-signaling cascade. NAE Elects New Members (Feb 14, 2011 | Vol. 89 Issue 07 | p. 8) Honors: Engineering academy welcomes 77 scientists, 18 of whom work in chemical areas. New Spin On Stereocontrol (Feb 14, 2011 | Vol. 89 Issue 07 | p. 9) Catalysis: Molecular motor takes turns at making each enantiomer, racemate in addition reaction. Science & Technology Concentrates (Member Content) (Feb 14, 2011 | Vol. 89 Issue 07 | pp. 34-35) Toxic Algae Produce Estrogens A hazardous cyanobacterium common in lakes turns on estrogen-related genes in fish. Lipid Cues Meningitis Bacteria’s Lethality Chemical modification switches bacteria from harmless to potentially pathogenic Platinum Nanocrystals Show Their Best Face A novel strontium titanate support material guides crystals to grow with nonstandard geometry Chemoselective Hunting Turns Up Natural Products Silyl-functionalized solid-support resins selectively home in on and pluck alcohols from extracts Neurotoxic Oligomer’s Structure Uncovered Small-angle X-ray scattering enabled researchers to analyze aggregated -synuclein associated with Parkinson’s disease Gold Sulfide’s Diverse Geometry A computational study has determined that S–Au–S building blocks are key to unique cluster structures Acid Catalyst Spurs Chiral Addition A Brønsted acid’s attachment to an alkene controls selectivity, but by a different pathway than metal catalysts Reaction Patterns Revealed In 3-D Researchers observe three-dimensional Turing diffusion patterns in a model chemical system for the first time February 7, 2011 Atmospheric Monitoring (Feb 7, 2011 | Vol. 89 Issue 06 | pp. 11-15) Recent field campaigns in California and Mexico brought together a plethora of scientists and techniques to analyze air quality and chemistry. Enabling Enzyme Studies (Feb 7, 2011 | Vol. 89 Issue 06 | pp. 28-30) Researchers unveil solutions to difficult problems at mechanisms conference. Peeling Away Nanosheets (Feb 7, 2011 | Vol. 89 Issue 06 | p. 6) Materials Science: Liquid exfoliation enhances materials' properties. Celebrating Chemistry (Feb 7, 2011 | Vol. 89 Issue 06 | p. 7) Solutions: International Year of Chemistry panel mulls 21st-century challenges. Linking Lomaiviticin (Feb 7, 2011 | Vol. 89 Issue 06 | p. 8) Organic Synthesis: Extensive search reveals metal complex that makes natural product's crowded bond. Oil Dispersants Persist In The Deep (Feb 7, 2011 | Vol. 89 Issue 06 | p. 8) Gulf Spill: Researchers find that an anionic surfactant lingers months after its use in response to the Deepwater Horizon oil spill. Science & Technology Concentrates (Member Content) (Feb 7, 2011 | Vol. 89 Issue 06 | pp. 26-27) Sugar Rules For Protein Drugs Guidelines show protein-drug designers where they can install sugars to improve stability and pharmacokinetics Holey Metal Films Go Transparent Thin films coated with a light-absorbing dye and dotted with microscopic holes can unexpectedly appear transparent Meet The Ivyanes Chemists create a new family of hydrocarbons in which cyclopropane rings hang off the sides of carbon chains Iron Oxide Nanocubes Enhance MRI Colloidal synthesis leads to contrast agents for single-cell and other ultrasensitive clinical applications Directed Evolution Helps Build Protein Containers Chemists figure out how to engineer nature’s ministorage devices to stockpile more stuff Photocatalysts In A Snap Embedding light-harnessing metal complexes in a polymer makes versatile, recyclable catalysts Ultrasmall Metal Clusters Act Metallic Bucking prior theory, sodium clusters with as few as three atoms have metallic character analogous to bulk metals X-Ray Pulses Yield Biological Structures Femtosecond pulses from the new Linac Coherent Light Source produce high-quality diffraction data January 31, 2011 Doctoral Dilemma (Jan 31, 2011 | Vol. 89 Issue 05 | pp. 46-52) Is chemistry facing a glut of Ph.D.s?. Vegetative Warfare (Jan 31, 2011 | Vol. 89 Issue 05 | pp. 53-55) Plants have evolved sophisticated weaponry to battle bacterial and fungal invaders. International Year Of Chemistry Launches (Jan 31, 2011 | Vol. 89 Issue 05 | p. 8) Opening Ceremony: Paris hosts chemistry delegates from around the world . Catalyst Makes A Novel Switch (Jan 31, 2011 | Vol. 89 Issue 05 | p. 10) Catalysis: Small-molecule iron complex has mixed activity that was exclusive to nature Parallel Printing At The Nanoscale (Jan 31, 2011 | Vol. 89 Issue 05 | p. 11) Lithography: Simplified patterning method reproducibly yields thousands of copies. Science & Technology Concentrates (Member Content) (Jan 31, 2011 | Vol. 89 Issue 05 | pp. 44-45) Cows Aid Quest For Biofuels By sequencing the DNA of cow gut microbes, researchers uncover a treasure trove of cellulose-degrading enzymes Chemical Lures For Cockroaches Researchers ID the compounds in stale beer and peanut butter that make roaches come running Extreme Hydrogen ‘Isotopes’ Illuminate Reaction Kinetics Using muons to create light and heavy hydrogen mimics, chemists upgrade the kinetic isotope effect Probing Chemical Timekeeping Scientists find a new role for posttranslational modification in circadian rhythms A Little Tug Speeds Up Collagen Cleavage Mechanical stress increases the rate at which structural collagen is degraded by an enzyme Nickel Complex’s Magnetic Switch Light-driven isomerization changes molecule’s coordination and thus its magnetic properties Biohybrid Catalyst Rapidly Produces H2 Photosystem I’s photosynthetic properties are exploited by coupling it to platinum nanoparticles Target Of Traditional Chinese Medicine Triptolide Found Uncovering natural product’s cellular target will facilitate the design of new anticancer and other drug leads January 24, 2011 Shotgun Approach To Drugs (Member Content) (Jan 24, 2011 | Vol. 89 Issue 04 | pp. 32-33) Pacifichem News: Polypharmacology gives rise to drugs with multiple targets. Tagging Cholesterol (Jan 24, 2011 | Vol. 89 Issue 04 | p. 8) Chemical Biology: Click chemistry helps label cholesterylated proteins. Enzymatic Revelation (Jan 24, 2011 | Vol. 89 Issue 04 | p. 9) Structural Biology: Structure provides insight into sugar-transferring enzyme. Giving DNA A Good Yank (Jan 24, 2011 | Vol. 89 Issue 04 | p. 10) Biophysics: Find adds fodder to question about nature of overextended DNA. Surprising Superoxide (Jan 24, 2011 | Vol. 89 Issue 04 | p. 11) Catalysis: Novel mode of end-on oxygen binding discovered in palladium complexes. Science & Technology Concentrates (Member Content) (Jan 24, 2011 | Vol. 89 Issue 04 | pp. 30-31) Knockout Pictures X-ray structures of general anesthetics binding to an ion channel could aid search for new anesthetics. Death By Reduction Chemical Biology: A cysteine-rich defensin peptide turns antimicrobial when reduced. Glutamine Probe Images Tumors Scientists could use the 18F-glutamine derivatives to track tumors that use glutamine as an alternative energy source. Bringing Disorder To Titanium Dioxide Change allows the photocatalyst to absorb beyond the ultraviolet range, into visible and infrared spectrum. Relativity Powers Batteries Lead-acid car batteries’ power stems from relativistic effects. January 17, 2011 Technology Renews A Basic Approach (Jan 17, 2011 | Vol. 89 Issue 03 | pp. 13-17) Dried blood spots offer advantages, but also challenges, for pharmaceutical analysis. IR Spectroscopy With Superbright Light (Member Content) (Jan 17, 2011 | Vol. 89 Issue 03 | pp. 34-35) Pacifichem News: Synchrotron beams enable spectroscopists to observe the biochemistry of cells. Cataracts Via Protein Interactions (Member Content) (Jan 17, 2011 | Vol. 89 Issue 03 | p. 36) Experimental, theoretical tools reveal a new route to the eye disease. CO2 Helps Crystals Change Shape (Jan 17, 2011 | Vol. 89 Issue 03 | p. 8) Pharmaceutical Chemistry: Polymorphs convert under mild conditions. A New Feat For Gold Catalysts (Jan 17, 2011 | Vol. 89 Issue 03 | p. 10) Catalysis: Gold-palladium nanoparticles exclusively transform primary C–H bonds. Hungary's Red Mud Catastrophe Packs A Punch On Plants (Jan 17, 2011 | Vol. 89 Issue 03 | p. 11) Industrial Accident: Sodium salt, more than heavy metals, from the bauxite reservoir spill may hurt crops. Science & Technology Concentrates (Member Content) (Jan 17, 2011 | Vol. 89 Issue 03 | pp. 32-33) 3-D Nanoscale Chemical Maps Of Teeth Tomography analysis reveals compositional differences in microscopic tooth structures Interfacial Properties Boost Lasing by Quantum Dots Two-monolayer-thin alloy layer in core-shell nanocrystals aids optics applications Amoebas Found In Treated Drinking Water Worldwide Water Treatment: Free-living amoebas that evade common disinfection treatments can host Legionella and other hazardous microorganisms Natural Product Sidesteps Drug Resistance In Yeast Enzyme inhibitor could lead to new pharmaceuticals Red Blood Cell Mimics Circulate Longer When Flexible Cross-linking chemistry imparts bio-like property to hydrogel microparticles Arsenate-Phosphate Debate Continues Review suggests controversy should stimulate interest in studies of enzyme promiscuity Gaseous Carbonic Acid Trapped And Analyzed Elusive molecule shown to exist in monomeric and dimeric forms One-Pot Method Produces Pyrroles Reaction converts aromatic alkynes to heterocycles in presence of palladium catalyst January 10, 2011 Peekaboo, H2 O2 (Member Content) (Jan 10, 2011 | Vol. 89 Issue 02 | pp. 32-33) Pacifichem News: New probes unravel more of the reactive molecule's biological roles. Regulating Rodents (Member Content) (Jan 10, 2011 | Vol. 89 Issue 02 | pp. 33-34) Pacifichem News: Scientists aim to control pests while minimizing harm to other species. Nanorings Synthesized Simply (Jan 10, 2011 | Vol. 89 Issue 02 | p. 4) Templating: Small templates and building blocks combine to make extra-large structures. Two's A Charm For Nickel Complex (Jan 10, 2011 | Vol. 89 Issue 02 | p. 4) Organometallics: Low-coordinate nickel species presents intriguing electronic structure and reactivity. Probing The Anomeric Effect (Jan 10, 2011 | Vol. 89 Issue 02 | p. 5) Carbohydrate Chemistry: Peptide sensor provides clues to phenomenon that stabilizes sugars. Extending Alkyne Versatility (Jan 10, 2011 | Vol. 89 Issue 02 | p. 8) Organic Intermediates: Selective cascade isomerization reaction converts alkynes into ,-diesters. Multimetal Organic Complexes (Jan 10, 2011 | Vol. 89 Issue 02 | p. 8) Synthesis: Method couples various metals in predetermined sequences. Science & Technology Concentrates (Member Content) (Jan 10, 2011 | Vol. 89 Issue 02 | pp. 30-31) Gold Catalysis Revisited A new study helps clear up the controversy over possible palladium-tainted gold catalysis Software Enables Speedier Metabolomics Program improves metabolite profiling by permitting an unlimited number of sample comparisons simultaneously Patterned Polymer Nanowire Arrays Polymer nanowires can be fabricated on a large scale via a combination of laser patterning and plasma etching New Method For Monitoring Heparin Tracking heparin-protamine nanoparticle formation could improve control of anticoagulation drugs during surgery Spinning Powder Into Yarn Rolling up titanium dioxide powder in carbon nanotube sheets yields fabrics that maintain the powder’s properties Trinitramide Debuts In a first for the chemistry of nitrogen, researchers have detected the high-energy compound N(NO2 )3 Sad Tears Carry Chemical Signals Scientists unearth a function for emotional tears—they can chemically influence the behavior of other individuals Oil-Leak Methane Consumed By Bacteria Methanotrophic bacteria made quick work of methane stemming from the Gulf of Mexico oil spill January 3, 2011 Chromatographers' Clarion Call (Member Content) (Jan 3, 2011 | Vol. 89 Issue 01 | pp. 25-26) Pacifichem News: To expand the menu of chiral selectors for separations, the expertise of synthetic organic chemists would be tremendously useful. Solar Fuel, With High Efficiency (Jan 3, 2011 | Vol. 89 Issue 01 | p. 8) Renewable Energy: Continuous cerium oxide-based syngas generator suggests possible industrial use. Elevating Oxygen (Jan 3, 2011 | Vol. 89 Issue 01 | p. 9) Spectroscopy: Technique yields unprecedented resolution in 17O NMR spectra of proteins in solution. Rare Sugar Linkage Revealed (Jan 3, 2011 | Vol. 89 Issue 01 | p. 10) Chemical Biology: Stable modified peptide leads team to a promising enzyme for synthesis. Science & Technology Concentrates (Member Content) (Jan 3, 2011 | Vol. 89 Issue 01 | pp. 35-36) Multifunctional Membranes Chemists engineer multicomponent block polymers to serve as nanoporous filtration membranes Solar-Powered Electrochemistry Organic oxidation reactions don’t need complicated setups or electricity from greenhouse-gas-emitting sources Vitamin D-3 Goes With The Flow A microreactor combines light-mediated and thermal reactions to improve a synthetic route to an important vitamin Improved Route To OCF3 Building Blocks Versatile strategy improves the synthesis of aliphatic organic molecules containing trifluoromethoxy groups Controlling Charge At The Atomic Level Surface patterning selectively alters the charge state of silicon atoms, which could help improve electronic devices Proline Triggers Mouse Stem Cell Differentiation... Researchers discover a first for an amino acid: Proline triggers embryonic stem cells to differentiate into neural cells … And Microfluidics Help Differentiate Stem Cells A microfluidic device could make it easier to control pluripotent stem cells for lab use Supercritical CO2 Delivers Retardants Using CO2 as a solvent for two “green” flame retardants dramatically improves cotton’s flame resistance

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