IMPORTANT SAFETY INFORMATION AND INDICATIONS Indications FIRVANQ™ (vancomycin hydrochloride) is a glycopeptide antibacterial indicated in adults and pediatric patients less than 18 years of age for the treatment of:
Subscribe My Alerts Log In
search
Advanced Search
All Issues
Collections
AJHP Residents Edition
AJHP Voices
Information For
About AJHP
Case Reports Print Content
Syndrome of inappropriate antidiuretic hormone associated with aripiprazole Felix K. Yam, Elizabeth A. Jackson and Brian K. Kwan American Journal of Health-System Pharmacy December 2013, 70 (23) 2110-2114; DOI: https://doi.org/10.2146/ajhp130142
Article
Info & Metrics
eLetters
PDF
In this issue American Journal of Health-System Pharmacy
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Vol. 70, Issue 23 1 Dec 2013 Table of Contents Index by author
Abstract Purpose A probable case of aripiprazole-induced syndrome of inappropriate antidiuretic hormone (SIADH) is reported.
Print
Share
Summary A 65-year-old Caucasian man arrived in the emergency
Download PDF
Tweet
department (ED) with dizziness, headache, abdominal pain, nausea, and
Article Alerts
Like 2
vomiting. There had been no recent additions or changes to the patient’s
Email Article Citation Tools
medication regimen except for an increase in the daily dose of aripiprazole
Respond to this
(from 10 to 20 mg) about two months prior. On admission, the patient’s
article
serum sodium concentration was 108 meq/L, prompting discontinuation of aripiprazole use and fluid restrictions. Over the next 72 hours, the serum
View this article with LENS
sodium level increased to a near-normal concentration (127 meq/L), and the man was discharged back to a nursing facility. Three days later, the patient was readmitted to the ED with recurrent symptoms and a serum sodium concentration of 118 meq/L, a serum osmolality of 254 mOsm/kg, a urine osmolality of 575 mOsm/kg, and a urine sodium concentration of 101 meq/L.
Jump to section
It was learned that aripiprazole use had been inappropriately resumed at the nursing facility. Aripiprazole was again discontinued, and fluid restrictions were imposed, with subsequent abatement of hyponatremia over four days. Application of the adverse drug reaction probability scale of Naranjo et al. in this case yielded a score of 7, indicating probable aripiprazole-associated SIADH.
Article Abstract Case report Discussion Conclusion Footnotes References
Conclusion A 65-year-old man developed severe hyponatremia after an
Info & Metrics eLetters
aripiprazole dosage increase. Hyponatremia resolved promptly with the discontinuation of aripiprazole. After discharge from the hospital, the patient
PDF
inadvertently received aripiprazole again and was subsequently readmitted with another episode of severe hyponatremia.
No related articles found. Scopus PubMed Google Scholar
View Full Text
Cited By...
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00 Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
More in this TOC Section Similar Articles
ASHP MEMBERS AND SUBSCRIBERS: Click here to sign in using your ASHP username and password. If you already have a subscription, you may gain access using your ASHP username and password. ADMINISTRATORS: Click here to sign in as an Administrator. Log in through your institution via Institution
via OpenAthens
You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password. If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
Previous
Next Back to top
Content
Navigate
Follow/Contact AJHP
Information For
Current Issue
AJHP Voices
Twitter
Authors/Reviewers
All Issues
AJHP Statement of Ownership
RSS
Members/Subscribers
Collections
Order Reprints
Alerts
Institutions/Libraries
AJHP Resident Edition
Request Permissions
Contact Us
Advertisers
AJHP Supplements
Feedback
Ahead of Print
Help
Other Resources ASHP ASHP Foundation ASHP eLearning