Idea Transcript
The Journal of
PHARMACOLOGY And Experimental Therapeutics A Publication of the American Society for Pharmacology and Experimental Therapeutics
April 2015
Vol. 353, No. 1 Contents
HIGHLIGHTED PAPERS
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The Evolving Role of Nonsteroidal Anti-Inflammatory Drugs in Colon Cancer Prevention: A Cause for Optimism Basil Rigas and George J. Tsioulias
2
Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation Ying-Ya Li, Jiao Feng, Xiao-Lu Zhang, and Ying-Yu Cui
9
BEHAVIORAL PHARMACOLOGY
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Interactions between Bupropion and 3,4-Methylenedioxymethamphetamine in Healthy Subjects Yasmin Schmid, Anna Rickli, Antonia Schaffner, Urs Duthaler, Eric Grouzmann, Cédric M. Hysek, and Matthias E. Liechti
102
Glycine Receptors Containing a2 or a3 Subunits Regulate Specific Ethanol-Mediated Behaviors Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Courtney R. Leiter, Elizabeth Osterndorff-Kahanek, and R. Adron Harris
181
CELLULAR AND MOLECULAR S
Species-Specific Influence of Lithium on the Activity of SLC13A5 (NaCT): Lithium-Induced Activation Is Specific for the Transporter in Primates Elangovan Gopal, Ellappan Babu, Sabarish Ramachandran, Yangzom D. Bhutia, Puttur D. Prasad, and Vadivel Ganapathy
17
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Cholesteryl Ester-Transfer Protein Inhibitors Stimulate Aldosterone Biosynthesis in Adipocytes through Nox-Dependent Processes Francisco J. Rios, Karla B. Neves, Aurelie Nguyen Dinh Cat, Sarah Even, Roberto Palacios, Augusto C. Montezano, and Rhian M. Touyz
27
Differential Pathway Coupling of the Activated Insulin Receptor Drives Signaling Selectivity by XMetA, an Allosteric Partial Agonist Antibody Daniel H. Bedinger, Ira D. Goldfine, John A. Corbin, Marina K. Roell, and Sean H. Adams
35
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Dual Regulation of d-Opioid Receptor Function by Arachidonic Acid Metabolites in Rat Peripheral Sensory Neurons Laura C. Sullivan, Kelly A. Berg, and William P. Clarke
44
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Aryl Hydrocarbon Receptor–Dependent Stanniocalcin 2 Induction by Cinnabarinic Acid Provides Cytoprotection against Endoplasmic Reticulum and Oxidative Stress Aditya D. Joshi, Dwayne E. Carter, Tod A. Harper Jr., and Cornelis J. Elferink
201
DRUG DISCOVERY AND TRANSLATIONAL MEDICINE S
Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor Involved in Peptide Activity and Small-Molecule Allostery Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos, and Patrick M. Sexton
52
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Discovery of Anti–Claudin-1 Antibodies as Candidate Therapeutics against Hepatitis C Virus Mayo Yamashita, Manami Iida, Minoru Tada, Yoshitaka Shirasago, Masayoshi Fukasawa, Shotaro Nagase, Akihiro Watari, Akiko Ishii-Watabe, Kiyohito Yagi, and Masuo Kondoh
112
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MINIREVIEWS
119
Neutral Endopeptidase-Resistant C-Type Natriuretic Peptide Variant Represents a New Therapeutic Approach for Treatment of Fibroblast Growth Factor Receptor 3–Related Dwarfism Daniel J. Wendt, Melita Dvorak-Ewell, Sherry Bullens, Florence Lorget, Sean M. Bell, Jeff Peng, Sianna Castillo, Mika Aoyagi-Scharber, Charles A. O’Neill, Pavel Krejci, William R. Wilcox, David L. Rimoin, and Stuart Bunting
132
2-Acetylcyclopentanone, an Enolate-Forming 1,3-Dicarbonyl Compound, Is Cytoprotective in Warm IschemiaReperfusion Injury of Rat Liver Boleslav Kosharskyy, Amaresh Vydyanathan, Lihai Zhang, Naum Shaparin, Brian C. Geohagen, William Bivin, Qiang Liu, Terrence Gavin, and Richard M. LoPachin
150
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The Small-Molecule Fast Skeletal Troponin Activator, CK-2127107, Improves Exercise Tolerance in a Rat Model of Heart Failure Darren T. Hwee, Adam R. Kennedy, James J. Hartman, Julie Ryans, Nickie Durham, Fady I. Malik, and Jeffrey R. Jasper
159
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Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression Lothar Lindemann, Richard H. Porter, Sebastian H. Scharf, Basil Kuennecke, Andreas Bruns, Markus von Kienlin, Anthony C. Harrison, Axel Paehler, Christoph Funk, Andreas Gloge, Manfred Schneider, Neil J. Parrott, Liudmila Polonchuk, Urs Niederhauser, Stephen R. Morairty, Thomas S. Kilduff, Eric Vieira, Sabine Kolczewski, Juergen Wichmann, Thomas Hartung, Michael Honer, Edilio Borroni, Jean-Luc Moreau, Eric Prinssen, Will Spooren, Joseph G. Wettstein, and Georg Jaeschke
213
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL Inhibiting Protein Arginine Deiminases Has Antioxidant Consequences Erin E. Witalison, Xiangli Cui, Anne B. Hofseth, Venkataraman Subramanian, Corey P. Causey, Paul R. Thompson, and Lorne J. Hofseth
64
INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA Ginsenoside Metabolite Compound K Suppresses T-Cell Priming via Modulation of Dendritic Cell Trafficking and Costimulatory Signals, Resulting in Alleviation of Collagen-Induced Arthritis Jingyu Chen, Huaxun Wu, Qingtong Wang, Yan Chang, Kangkang Liu, and Wei Wei S
The Effect of Phytocannabinoids on Airway Hyper-Responsiveness, Airway Inflammation, and Cough Raj Makwana, Radhakrishnan Venkatasamy, Domenico Spina, and Clive Page
71
169
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS S
Contribution of Pannexin 1 and Connexin 43 Hemichannels to Extracellular Calcium–Dependent Transport Dynamics in Human Blood-Brain Barrier Endothelial Cells Yosuke Kaneko, Masanori Tachikawa, Ryo Akaogi, Kazuhisa Fujimoto, Megumi Ishibashi, Yasuo Uchida, Pierre-Olivier Couraud, Sumio Ohtsuki, Ken-ichi Hosoya, and Tetsuya Terasaki
192
NEUROPHARMACOLOGY S
Control of Ethanol Sensitivity of the Glycine Receptor a3 Subunit by Transmembrane 2, the Intracellular Splice Cassette and C-Terminal Domain Andrea Sánchez, Gonzalo E. Yévenes, Loreto San Martin, Carlos F. Burgos, Gustavo Moraga-Cid, Robert J. Harvey, and Luis G. Aguayo
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Cysteine Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN1/GluN2A N-Methyl-D-Aspartate Receptors Minfu Xu, C. Thetford Smothers, and John J. Woodward
91
S Supplemental material is available at http://jpet.aspetjournals.org.
About the cover: Basimglurant [3H]ABP688 in receptor occupancy studies and [3H]basimglurant in vivo binding in rat. See the article by Lindemann et al. (dx.doi.org/10.1124/jpet.114.222463).
Downloaded from jpet.aspetjournals.org at ASPET Journals on January 4, 2019
Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity–Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor–Binding Enhancement Kirk R. Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C. Matsuda, Ren Xu, Lei Zhou, Joyce C. Y. Chan, Chadwick King, Derek E. Piper, Randal R. Ketchem, Mark Leo Michaels, Simon M. Jackson, and Marc W. Retter
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