Dialogues Clin Neurosci. 2010 Sep; 12(3): 271–287.
PMCID: PMC3181977
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The diagnostic concept of schizophrenia: its history, evolution, and future prospects Assen Jablensky, MD Assen Jablensky, Professor of Psychiatry, Director, Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Perth, Australia; E-mail:
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Abstract
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A brief overview of the history of the concept
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Kraepelin and the construction of dementia praecox
Bleuler's “group of schizophrenias”
Post-Kraepelinian and post-Bleulerian subtypes and dichotomies
Leonhard's alternative classification of the “endogenous” psychoses
The notion of a schizophrenia spectrum
Positive-negative schizophrenia (“Type I” and “Type II”)
Deficit-nondeficit schizophrenia
Statistically derived symptom dimensions or clusters
Familial-sporadic schizophrenia
The present diagnostic classifications: DSM-IV and ICD-10
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The vexing issue of validity versus utility
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Categories and/or dimensions?
Endophenotypes in schizophrenia
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Cognitive dysfunction as an endophenotype
Conclusion: the way forward
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REFERENCES
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