the effect of the molecular properties of calcium channel ... - doiSerbia [PDF]

1. The relationship between CCB renal elimination data col- lected from the literature (A) and predicted (B) using ClogP

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Arch. Biol. Sci., Belgrade, 67(3), 801-806, 2015

DOI:10.2298/ABS150127039T

THE EFFECT OF THE MOLECULAR PROPERTIES OF CALCIUM CHANNEL BLOCKERS ON THEIR ELIMINATION ROUTE Jasna B. Trbojević-Stanković1,2, Jadranka V. Odović3, Ratomir M. Jelić4, Dejan M. Nesić5,*, Biljana B. Stojimirović1,6 School of Medicine, University of Belgrade, Belgrade, Serbia; Department of Dialysis, Clinical Hospital Center “Dr Dragiša Mišović”, Belgrade, Serbia; 3 Department of Analytical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia; 4 Faculty of Medicinal Science, University of Kragujevac, Kragujevac, Serbia; 5 Institute of Medical physiology, School of Medicine, University of Belgrade, Belgrade, Serbia; 6 Clinic of Nephrology, Clinical Center of Serbia, Belgrade, Serbia; 1 2

Corresponding author: [email protected], [email protected]

*

Abstract: Calcium channel blockers (CCBs) are among the most widely used drugs in cardiovascular medicine. In this study, nine CCBs (amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem) were investigated to assess the relationship between their molecular properties and elimination data obtained from literature. The descriptors of the molecular properties of CCBs were calculated using three software packages. The relationship between computed molecular properties and elimination data collected from relevant literature, initially investigated with simple linear regression analysis, showed poor correlation (R2

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