THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 [PDF]

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) SUBJECT – ORGANIC CHEMISTRY-I Code:

CREDITS: 4

TEACHING HOURS: 75

OBJECTIVES OF THE COURSE: This course aims to explain basic concepts in stereochemistry and conformational analysis of organic molecules. In addition the reaction mechanism and synthetic applications of aliphatic and aromatic substitution reaction in organic synthesis will be discussed in detail.

Unit I: Stereochemistry I

(15 hours)

Optical activity and Chirality Classification of chiral molecules as asymmetric and dissymmetric – a brief study of dissymmetry of allenes, biphenyls, spiro compounds, trans cyclooctene, cyclononene and molecules with helical structure – Absolute configuration: R,S notation of biphenyls and allenes – Fischer projections: Interconversion of sawhorse, Newmann and Fisher’s projections UNIT II: Stereochemistry II

(15 hours)

Molecules with more than one symmetric center (restricted to five carbons) Erthyro and Threo compounds- Asymmetric synthesis, Cram’s rule and optical purity. Geometrical and Optical isomerism (if shown) of disubstituted cyclopropane, cyclobutane and cyclopentanes – Identification of homotopic, enantiotopic, diastereotopic compounds containing upto ten carbons only – Stereo

UNIT III: Conformational Analysis

hydrogens and prochiral carbons in

specific and stereo selective reactions.

(15 hours)

Conformational analysis of some simple 1,2 disubstituted ethane derivatives. Conformational analysis of disubstituted cyclohexanes and their stereo chemical features [Geometrical and optical isomerism (if shown) by these derivatives]. Conformation and reactivity of substituted cyclohexanols (Oxidation and acylation), (esterification and hydrolysis) Conformation and stereochemistry of Cis and trans decalins and 9 – methyl decalin. Unit IV: Aliphatic Nucleophilic Substitution reactions 4.1

(15 hours)

Mechanisms of aliphatic nucleophilic substitution reactions. SN1, SN2, SNi neighbouring group

participation mechanisms by double bond, OMe, halogens and NH 2 reactivity, structural and solvent effects – substitution in norbornyl and bridgehead systems. 4.2

Substitution at allylic and vinylic carbons. Substitution by ambident nucleophiles.

4.3

Nucleophilic substitution at carbon doubly bonded to oxygen and nitrogen. Alkylation and

acylation of amines, halogen exchange. Von Braun reaction. Unit V: Aromatic Electrophilic & Nucleophilic Substitution reactions 5.1

(15 hours)

Kinetic and non kinetic methods of determining organic reaction mechanisms. Hammet

equation: Derivation and free energy relationship – simple problems. Taft equation. 5.2

Aromatic electrophilic substitution reactions. Arenium ion mechanism, orientation and

reactivity 5.3

Aromatic nucleophilic substitution reactions mechanisms: SNAr, Aryne, SN1, Zeigler

alkylation, Chichibabin reaction. Text books 1. J.March, 1992, Advanced Organic Chemistry, 4th edition, John Wiley & Sons, Singapore. 2. E.Eliel, S.H.Wilen and L.N.Mander, 1994, Stereochemistry of Carbon Compounds, 2nd Edition, John Wiley & Sons, New York. 3. D.Nasipuri, 1984, Stereochemistry of Organic Compounds, 2nd Edition, Wiley Eastern Ltd., New Delhi. 4. P.S.Kalsi, 1994, Stereochemistry, Conformational Analysis and Mechanism, 2nd Edition, Wiley Eastern Ltd., Chennai.

5. Niel Isaacs, 1987, Physical Organic Chemistry, ELBS Publications 6. F.A.Carey and R.J.Sundberg, 2001, Advanced Organic Chemistry, Part A and Part B, 4th Edition, Plenum Press, New York. 7. T.L.Gilchrist, Carbenes, Nitrenes & Arynes, Thomas Nelson & Sons Ltd., London. 8. R.Bruckner, 2002, Advanced Organic Chemistry, Reaction Mechanism, Elsevier, New Delhi.

THE NEW COLLEGE (AUTONOMOUS),CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the year 2009-2010) INORGANIC CHEMISTRY –I CODE:

CREDITS:

TEACHING HOURS: 75

Objectives of the course: The student can gain the full knowledge and understanding of all aspects of inorganic polymers, theories about bonding and structure of various inorganic compounds and coordination chemistry. Unit I – Bonding in inorganic compounds:

(10 hours)

Poly acids: Isopolyacids and heteropolyacids of vanadium, chromium, molybdenum and tungsten. Inorganic Polymers: Silicates, structure – properties – correlation and applications – molecular sieves polysulphur – nitrogen compounds and polyorganophosphazenes. Unit II

(10 hours) Boron hydrides: Polyhedral boranes, hydroborate ions, carboranes and metallo carboranes.

Metal Clusters: Chemistry of low molecularity metal clusters (upto) trinuclear metal clusters; multiple metal – metal bonds. Unit III – Theories of coordination:

(25 hours)

Crystal field theory and its limitations, d-orbital splittings, LFSE and its calculations, spectrochemical series, evidences for metal ligand orbital overlap, molecular orbital theory and energy level diagrams, concept of weak and strong fields, Jahn-Teller distortion, charge-transfer spectra. Electronic spectra, d-d transitions, spectral and magnetic characteristics of transition metal complexes, Term states for dn – ions, energy diagrams, Orgel and Sugano – Tanabe diagrams, spin orbit coupling, nephelauxetic effect, Hole formalism tedchniques, Racah parameter,

Unit IV – Stability of coordination complexes:

(20 hours)

Stability of complexes: thermodynamic stability – stepwise and overall stability constants, their relationships, factors affecting the stability of the complexes, HSAB approach, chelate effect, importance of chelates. Determination of stability constants by spectrophotometric, polarographic and potentiometric methods. Macrocyclic ligands; types; Schiff bases; Template effect, crown ethers; cryptands. Unit V – The chemistry of lanthanides and actinides

(10 Hrs)

Lanthanides and actinides: Oxidation states - magnetic and spectral properties – Coordination numbers, stereochemistry. Nuclear and non-nuclear applications of lanthanides including use of lanthanides as shift reagents. Text books: 1. Huheey, 1993, Inorganic Chemistry – Principles, Structure and Reactivity; IV Edition, Harper Collins, NY. 2. F.A. Cotton and G. Wilkinson, 1988, Advanced Inorganic Chemistry – A Comprehensive Text, V. Edition, John Wiley & Sons. 3. K.F. Purcell and J.C. Kotz, 1977, Inorganic Chemistry – WB Saunders Co., USA. 4. Chemistry – A Comprehensive Text, V. Edition, John Wiley & Sons. 5. B.E. Dogulas DH MX Daniels and Alexander, 1983, Concepts and Models of Inorganic Chemistry, Oxford IBH. 6. M.C. Day and J. Selbin, 1974, Theoretical Inorganic Chemistry, Van Nostrand Co., NY. 7. G.S. Manku, 1984, Inorganic Chemistry, TMG Co., Suggested reference books: 1. D.F. Shrivers, P.W. Atkins and C.H. Langfor 1990, Inorganic Chemistry, CH Langford, OUP.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SEMESTER I - SYLLABUS (Effective from 2009-2010) PHYSICAL CHEMISTRY –I CODE:

CREDITS:

TEACHING HOURS: 75

OBJECTIVES : i)To learn the basic

concepts of quantum chemistry.To understand the concept of

spectroscopy & Group theory- their applications and significance. UNIT I : Quantum chemistry – I

(15 hours)

Inadequacy of classical theory: Bohr’s quantum theory and subsequent developments - Black body radiation – Photoelectric effect – the Compton effect – Wave particle duality – Uncertainty principle UNIT II : Quantum chemistry – II

(15 hours)

Postulates of quantum mechanics, Operator algebra, Schrodinger equation – elementary applications of Schrodinger’s equation – the particle in a box (one and three dimensional cases). UNIT III : Group Theory I

(15 Hours)

Introduction to group, classifications and their properties – symmetry elements and symmetry operations in molecules – point groups – identification and determination

– Matrix

representations – reducible and irreducible representations – Direct product representation – orthogonality theorem and its consequences – construction of UNIT IV : Spectroscopy I

character tables (C2v and C3v). (15 Hours)

Rotational Spectroscopy – Rigid and non rigid rotar – diatomic and triatomic molecules – effect of isotopic substitution.

Rotation energy in terms of molecular parameters – line spacing in terms of Rotational constant ‘B’ – Calculation of bond length. Vibrational spectroscopy-Harmonic and anharmonic oscillator frequency spectral line in terms of

ωosc

ωosc

position of

–Condition for IR activity –vibrational –rotational spectra of diatomic

molecule-origin of P,Q and R branches-vibrational spectra of polyatomic molecules-vibrational coupling overtones-Fermi resonance-Raman spectra-criteria for a molecule to be Raman active-pure Raman spectra and vibrational Raman spectra. UNIT V: Spectroscopy II

(15 Hours)

Electronic spectroscopy: Types of Electronic transitions-Frank condon principle-predissociationEffect of conjucation and solvent on electronic transitions. Nuclear Magnetic Resonance spectroscopy : Angular and magnetic motion of nucleus –Larmor frequency-Relaxation process-Relaxation time and its effect on line width-chemical shift-spin-spin coupling-coupling constant-NMR spectrum of simple A-X and AMX type molecules-FT NMR(Elementary idea)-C13 NMR- double resonance spectroscopy Text Books: 1. K.V. Raman, Group theory and its applications to Chemistry, Tata McGraw Hill, 1990. 2. C.N.Banwell, Fundamendals of Molecular Spectroscopy, Tata McGraw Hill, 2003. 3. D.A.McQuarrie, Quantum Chemistry, University Science Books, Mil Valley,California, 1983. 4. R.K.Prasad, Quantum Chemistry, New Age Publication, India, 1992 Reference : 1. V. Ramakrishnan and M.S. Gopinathan, Group theory in Chemistry VishalPublications, 1998. 2. T.N. Levine, Quantum chemistry, Allyn and Bacon, Boston, 1983. 3. R.Anantharaman Fundamentals of Quantum chemistry, McMillan India Ltd., 2001. 4. G.Aruldas, Molecular Structure and Spectroscopy, Prentice Hall, 2002. 5. K.L.Kapoor, A Text Book of Physical Chemistry, Macmillan India Ltd, 200 6. P.W.Atkins, Physical Chemistry , Oxford University Press

THE NEW COLLEGE (AUTONOMOUS), CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the year 2008-2009) SUBJECT- ORGANIC CHEMISTRY PRACTICAL-I CODE

CREDITS : 4

TEACHING HOURS: 90

Objectives of the course To train the students to synthesis an organic molecule involving one or two steps. To make the students enable to analyse the mixture of organic compounds systematically. UNIT I : 1 .Separation & identification of water insoluble compounds in a two component mixture preparation of their derivatives. (Aromatic hydrocarbons should be avoided) UNIT II :( Any five preparation from the following ) 1. Preparation of benzhydrol from benzophenone.. 2. Preparation of m-nitroaniline from m- dinitrobenzene. 3. Preparation of anthroquinone from anthracene. 4. Preparation of p- nitrobenzoic acid from p- nitrotoluene. 5. Preparation of o- benzylbenzoic acid. 6. Preparation of p- chlorotoluene from p-toluidene. 7. Preparation of diphenyl methane from benzyl chloride. 8. Preparation of methyl orange from sulphanilic acid. 9. Preparation of 1,2,3,4 – Tetrahydrocarbazole from cyclo hexanone. 10 Preparation of 2, 3- Dimethylindole from phenyl hydrazine and 2-butanone.

and

The New College (Autonomous) Chennai 600014 M.Sc. DEGREE BRANCH – IV CHEMISTRY SYLLABUS (Effective from the academic year 2008-2009) SUBJECT – PHYSICALCHEMISTRY- PRACTICAL I Code:

CREDIT

:4

TEACHING HOURS: 75

OBJECTIVES OF THE COURSE: To impart the basic concepts and make them understand the equations in physical chemistry by carrying out suitable related experiments List of Experiments for Physical Chemistry Practical. 1. Determine the rate constant and order of reaction for the reaction between potassium persulphate and potassium iodide and determine the temperature coefficient and energy of activation of the reaction. 2. Comparison of acid strength by ester hydrolysis. 3. Study the effect of ionic strength on the rate constant for the saponification of an ester. 4. Study the salt effect on the reaction between acetone and iodine. 5. Study the kinetics of the decomposition of sodium thiosulphate by a mineral acid. 6. Study the primary salt effect on the kinetics of ionic reactions and test the Bronsted relationship. 7. Determine the molecular weight of benzoic acid in benzene and find the degree of association. 8. Constructions of a phase diagram for a simple binary system. 9. Determine the equilibrium constant of the reaction between iodine and potassium iodide by partition method. 10. Construction of the phase diagram of the three component of partially immiscible liquid system. 11. Study the absorption of acetic acid by charcoal.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY M.Sc., DEGREE: BRANCH –IV CHEMISTRY

Code:

SYLLABUS Elective 1- Natural Products & Bio Organic Chemistry CREDITS: 4 TEACHING HOURS: 60

OBJECTIVES OF THE COURSE: This paper discusses the bio synthesis of alkaloids, terpenoids and some heterocyclic compounds. A brief study of biochemistry is also included. Unit-I: Heterocyclic compounds 1.1 Synthesis and reactions of Imidazole, Oxazole, Thiazole.

(15 hours)

1.2 Natural pigments: General methods of determining structure and synthesis. Cyanin chloride and Hirsudin chloride. Flavones and flavonols: General method of determining structure. Synthesis Quercetin. Isoflavonol, Isoflavones-Diadzein, 1.3 Synthesis of purines (adenine, guanine) pyrimidines (cytocine and uracil only) Unit: II Terpenes & Steroids: (15 hours) 2.1 Terpenes: Classification, structural elucidation by chemical degradation and synthesis of α-Pinene, Camphor, Zingiberene, β-Carotene. 2.2 Steroids: Structural elucidation of Cholesterol (by chemical degradation). Conversion of cholesterol to progesterone, esterone and testosterone. Unit-III Alkaloids and Vitamins (15 hours) 3.1 Alkaloids: Classification, Structural elucidation by chemical degradion and synthesis of morphine, reserpine, quinine, cocaine. 3.2 Vitamins: Vitamin A, B1, B2, B6 (Synthesis only). Unit-IV Bio Organic Chemistry: (15 hours) Structure and role of DNA and RNA.. Genetic code. Biosynthesis of Cholesterol and bile acids only.

Text books 1. L. Stryer, Biochemistry, W. H. Freeman & Co., New York. 2. Agarwal, Chemistry of Organic Natural Products, Goel Publishing House. 3. I. L. Finar, 1986, Organic chemistry, 5th edition, Volume II, ELBS Publications.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) SUBJECT-ORGANIC CHEMISTRY-II CODE :

CREDITS :4

TEACHING HOURS: 75

OBJECTIVES OF THE COURSE: This paper explains the basic concepts of addition reaction of carbon-carbon double and elimination reaction. In addition , some of the important rearrangement in organic chemistry will be discussed. The last part of the course brings forth the salient features of oxidation and reduction reactions in organic synthesis. UNIT I: Addition to carbon-carbon and carbon-hetero atom multiple bonds (15 hours) Electrophilic, Nuclophilic and neighbouring group participation mechanisms – Addition of halogens , nitrosyl chloride to olefins – Hydroboration, hydroxylation, Michael addition, Diel’s-Alder reaction, 1,3 – dipolar addition, Simmon Smith reaction, Mannich reaction, Darzen, Wittig- Horner, Benzoin condensation. UNIT II: Elimination Reactions

(15 hours) Mechanism: E1, E2,

E1CB and Ei. E1-E2 - E1CB spectrum. Orientation of double bonds – Hoffmann and Saytzeff rule – Elimination vs Substitution – Stereochemistry of E2 elimination in cyclohexane derivatives – Chugaev and Cope elimination.

UNIT III: Molecular Rearrangements

(15 hours)

A detailed study with suitable examples of mechanisms of the following rearrangements – Pinacol – Pinacolone ( other than tetra methyl ethylene glycol), Wagner Meerwin, Demjanov, Dienone – Phenol, Favorskii, Bayer – Villiger, Wolff, Stevens, Sommelet – Hauser rearrangement and Von Richter rearrangement.

UNIT IV: Oxidation

(15 hours)

Oxidation – Mechanism – study of the following oxidation reactions – oxidations of alcohols using PDC, PCC, MnO2, DMSO in combination with DCC and acetic anhydride, Sarrett & Collins reagents. Oxidation of methylene to carbonyl - oxidation of aryl methanes – allylic oxidation of olefins – Oppenaur oxidation, Corey- Kim oxidation, Dess – Martin periodinane. UNIT V: Reduction

(15 hours)

Reductions – selectivity in reduction of 4 – tert- butyl cyclohexanone using

LiAlH4 and

selectrides – hydride reductions – synthetic importance of Clemmenson and Wolff – Kishner reduction – modification of Woff – Kishner reduction – Birch reduction – MPV reduction. Text books 1. F. A. Carey and R. J. Sundberg, 2001, Advanced Organic Chemistry, Part A and Part B, 4th edition, Plenum Press, NewYork. 2. J. March, 1992, Advanced Organic Chemistry, 4th edition, John Wiley & Sons, Singapore. 3. Niel Isaacs, 1987, Physical Organic Chemistry, ELBS Publications. 4. W.Currethers, 1993, Some Modern Methods of Organic Synthesis, 3rd edition, Cambridge University Press. 5. H. O. House, 1972, Modern Synthetic Reactions, TheBenjamin Cummings Publishing Company, London. 6. R.Bruckner, 2002, Advanced Organic Chemistry, Reaction mechanism, Elsevier, New Delhi.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) INORGANIC CHEMISTRY –II CODE:

REDITS:

TEACHING HOURS: 75

Objectives of the course: The student can gain the full knowledge and understanding of basics of reaction mechanisms in coordination chemistry solid state chemistry and few analytical techniques. Unit I – The chemistry of solid state – I

(20 hours)

Structure of Solids; Comparison of X-Ray, Neutron and Electron Diffraction; Structure of ZnS, Rutile, Pervoskite, Cadmium iodide and Nickel arsenide; spinels and inverse spinels; defects in solids, non-stoichometric compounds. Use of X-Ray powder diffraction data in identifying inorganic crystalline solids, details for cubic systems. Unit II – The chemistry of solid state – II

(10 hours)

Band theory, Semiconductors, Superconductors, Solid State Electrolytes, Types of Magnetic Behaviour – Dia, Para, Ferro, Antiferro and ferrimagnetism, Hysterisis, Solid State Lasers, Inorganic Phosphorus, Ferrites, Garnets. Reactions in Solid State and Phase Transitions, Diffusion, Diffusion Coefficient, Diffusion Mechanisms, Valency and Interstitial Diffusion, Formation of Spinels. Solid Solutions: Order-Disorder Transformations and Super Structure. Unit III – Reaction mechanisms of coordination compounds:

(10 hours)

Electron transfer reactions: Outer and inner sphere processes, atom transfer reactions, complementary and non-complementary reactions. Formation and rearrangement of precursor complexes, the binding ligands. Successor complexes, Marcus theory. Unit IV – Substitution reactions in coordination compounds

(20 hours)

Substitution Reactions: substitution in square planar complexes, reactivity of platinum complexes, influences of entering, leaving and other groups, the trans-effect.

Substitution of octahedral complexes of cobalt and chromium, replacement of coordinated water, solvolytic (acids and bases) reactions applications in synthesis (platinum and cobalt complexes only). Rearrangement in 4 and 6 coordinate complexes: reaction at coordinated ligands – template effect. Unit V – Water analysis and treatment

(15 hours)

Sources of water, Hardness of water – Temporary and permanent hardness, Alkalines and non alkaline hardness. Estimation of soap solution method, EDTA method. Units of hardness parts per million (ppm), equivalence per million (epm), Grains per imperial gallon (g.p.g.) Alkalinity, Methods of treatment of water for domestic and industrial purposes – Sedimentation, Coagulation – Effect of pH on coagulation, Filtration – slow sand, rapid gravity and rapid pressure filtrations, Sterilization of water – by chlorine, ozone and UV radiations. Text Books: 1. K.F. Purcell and J.C. Kotz, 1977, Inorganic Chemistry – WB Saunders Co., USA. 2. J.E. Huheey, 1993, Inorganic Chemistry – Principles, Structure and Reactivity; IV Edition, Harper Collins, NY. 3. F.A. Cotton and G. Wilkinson, 1988, Advanced Inorganic Chemistry – A Comprehensive Text, V. Edition, John Wiley & Sons. 4. B.E. Dogulas DH MX Daniels and Alexander, 1983, Concepts and Models of Inorganic Chemistry, Oxford IBH. 5. W.U. Mallik, G.D. Tuli, R.D. Madan, 1992, selected topics in Inorganic Chemistry, S. Chand & Co., New Delhi. 6. A.R. West, 1991, Basic Solid State Chemistry, John Wiley. 7. W.E. Addison, 1961, Structural Principles in Inorganic Chemistry, Longman.

8. M. Adams, 1974, Inorganic Solids, John Wiley Sons. 9. D.A. Skoog, 1985, Principles of Instrumental methods of Analysis, III Edition, Saunders College Publication. 10. Willard Merrit, Dean and Settle, 1986, Instrumental methods of Analysis, VI Edition, CBS Publication. 11. A.I. Vogel, 1985, 1976, Text Book of Qualitative Inorganic Analysis, ELBS III Edition, and IV Edition. 12. D.A. Skoog D.M. West, 1982, Fundamental of Analytical Chemistry, IV Edition, Holt Reinheart & Winston Publication. 13. A Text Book of Engineering chemistry (1986) – S.S.Dara, S.Chand and Company Limited.

14. Lab Manual by Metro Water Resource Centre (MWSSB), Chennai – 23. Suggested reference books: 1. S.F.A. Kettle, 1973, Coordination Chemistry, ELBS. 2. B.N. Figgis, 1966, Introduction to Ligand Fields, Interscience. 4. D. Nicholas, 1974, Complexes of First Row Transition Elements. 4. M.C. Shrivers, PW. Atkins, CH Langford, 1990, Inorganic Chemistry, OUR. 5. M.C. Day and J. Selbin, 1974, Theoretical Inorganic Chemistry, Van Nostrand Co., NY. 6. G.S. Manku, 1984, Inorganic Chemistry, TMG Co., 7. A.F. Wells, 1984, Structural Inorganic Chemistry, V Edition, Oxford. 8. A.R. West, 1990, Solid State Chemistry, John Wiley. 9. G.D. Christian & J.E.O. Reily, 1986, Instrumental Analysis, II Edition, Allegn

Recon. 10. H.A. Strobel, 1976, Chemical Instrumentation, Addition – Wesely Publ. Co. 11. Kolthoff and Elwing (All Series) – Treatise on Analytical Chemistry. 12. Willson Series – Comprehensive Analytical Chemistry. 13. H.A.O. Hill and P. Day, 1968, Physical methods in Advanced Inorganic Chemistry, John Wiley. 14. K. Burger, 1973, Coordination Chemistry, Experimental methods, Butterworths.

THE NEW COLLEGE (AUTONOMOUS),CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SEMESTER II-SYLLABUS (Effective from 2009-2010) PHYSICAL CHEMISTRY –II CODE:

CREDITS:

TEACHING HOURS: 75

OBJECTIVES : To enable the students to learn the basic concepts of classical thermodynamics. ii)To understand the difference approximation methods in quantum chemistry, & Group theoryapplications UNIT I: Quantum chemistry – III

(15 hours)

Applications of Schrodinger equation - Harmonic oscillator, rigid rotator.– equation for hydrogen atom

Schrodinger

(no derivation is required) – quantum numbers- their physical

significance. UNIT II: Quantum Chemistry IV

(15 Hours)

Perturbation and variation methods – application to hydrogen and helium atoms. Born – Oppenheimer approximation – valence bond theory for hydrogen molecule –LCAO – MO theory for di and polyatomic molecules – concept of hybridization – Huckel theory for ethylene and conjugated molecules -butadiene and benzene UNIT III: Group Theory II

(15 Hours)

Hybrid orbitals of non – linear molecules (H2O, NH3, BF3, CH4 and XeF4). Determination of representations of vibrational modes in non – linear molecules (H2O , NH3, BF3, CH4, XeF4 , SF6) Symmetry selection rules for infra red, Raman and electronic spectra. Electronic spectra of HCHO and CH2==CH2 – Applications of group theory.

UNIT IV: Thermodynamics I

(15 Hours)

Partial molar quantities – partial molar volume and partial molar heat content. Chemical potential – physical significance and dependence on other variables. Thermodynamics of real gases – fugacity – variation of fugacity with temperature and pressure. UNIT V: Thermodynamics II

(15 Hours)

Activity and activity coefficient of non electrolytes and electrolytes. Determination of activity co-efficient by e.m.f. method and cryoscopic methods. Choice of standard state. Text Books 1. K.V. Raman, Group theory and its Applications to Chemistry, Tata McGraw Hill, 1990. 2. P.W. McQuarrie, Quantum Chemistry, University Science Books, Mil Valley,California, 1983. 3. S.Glasstone, Thermodynamics for Chemists, Affiliated East West Press, New Delhi, 1960. 4. J. Rajaram and J.C. Kuriacose, Thermodynamics for Students of Chemistry, Lal Nagin Chand, New Delhi, 1986. Reference : 1. V. Ramakrishnan and M.S. Gopinathan, Group theory in Chemistry, Vishal Publications,

1998.

2.T.N. Levine, Quantum chemistry, Allyn and Bacon, Boston, 1983.

The New College (Autonomous) Chennai 600014 M.Sc. DEGREE BRANCH – IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) SUBJECT – INORGANIC CHEMISTRY- PRACTICAL- I Code:

CREDITS:

TEACHING HOURS: 90

OBJECTIVES OF THE COURSE: To train the candidate in inorganic compound, separation of the two metal ions by chromatographic method and deduction identification of cations by an semi micro method.

Unit: 1: Semi micro qualitative analysis of mixtures containing two common and two rare cations. The following are the rare cation to be included: W, Mo, Ti, Se, Ce, Th, Zr, V, U and Li. Unit: 2: Conformational Analysis a. Preparation of the following: 1. Potassium tris (oxalato) aluminate (III) trihydrate. 2. Tris (thiourea) copper (1) Chloride. 3. Potassium tris (oxaloto) chromate (III) trihydrate. 4. Sodium bis (thiosulphato) cuprate(I). 5. Tris (thiourea) copper (I) Sulphate. 6. Sodium bexanitrocobalite(III) 7. Chloropentamine cobalt (III) chloride. 8. Bis (acetylacetanato) copper (II) 9. Hexaminenickel (II) chloride 10. Bis (thiocynato) Pyridine manganese (II) b. 1. Separation of a mixture of two metal ions by paper chromatography. 2. Seperation of Zinc and Magnesium on an anion exchanger.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010)

BIO - INORGANIC CHEMISTRY (SEMESTER II) CODE

CREDITS: 3

TEACHING HOURS: 60

Objectives of the course: This paper enables the student to understand the role of inorganic substances in biological systems. Unit I (10 Hrs) Enzymesnomenclature and classification. Enzyme kinetics, free energy of activation and the effects of catalysis. Michel’s –Menton equation-Effect of pH, temperature on enzyme reactions. Factors contributing to the efficiency of enzyme ,study spectroscopy methods. Unit II

(10 Hrs) Metal storage: Transport and biomineralization:Ferritin transferritin and sidorphores-Na, K,

balance Metalloenzymes: Zinc enzymes carboxypeptidase, carbonic anhydrase Peroxidase and catalyses Super oxide dismutase and Copper Proteins. Heme-enzyme-. Coenzymes –Vitamin-B12 coenzymes, Unit II

( 10 Hrs)

Transport Proteins: Oxygen carriers- , Hemoglobin and myoglobin – Structure and oxygenation – Bohr effect, porphyrings. Non-heme oxygen carriers- Hemerythrin and hemocyanin. Unit IV

(20 Hrs)

Nitrogen fixation-Introduction, types of nitrogen fixing micro organisms. Nitrogenase enzyme – Metal clusters in nitrogenase – redox property - Dinitrogen complexes- transition metal complexes of dinitrogen – nitrogen fixation via nitride formation and reduction of dinitrogen to ammonia.

Biological redox system : Cytochromes – Classification , cytochrome a, b and c. Cytochrome P450. Photosynthesis and chlorophylls. Unit V

(10 Hrs) Metals in medicine: Toxicity of Hg, Cd, Zn, Pb, As, Sb. Anticancer agents.

Metal ion poisoning: Failure of metal ion control systems , role of metal ion diagnosis and treatmentuse of radio isotopes . Text Books: 1. Williams,D.R. –Introdution to Bioinorganic chemistry 2. Fiabre, F.M., and Williams D.R. – The principles of Bioinorganic chemistry, Royol Soceity of chemistry, Monograph for Teachers-31 3. Purcell, K.F. and Kotz., Inorganic chemistry, WB Saunders Co., USA. 4. G.N. Mugherjee and Arabinda Das, Elements of Bioinorganic chemistry-, 1993. 5. M.Satake and Y.Mido, Bioinorganic chemistry- Discovery Publishing House, New Delhi (1996) 6. 3. M.N. Hughes, 1982, The Inorganic Chemistry of Biological processes, II Edition, Wiley London.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) EDE 1, SUBJECT – PHOTOCHEMISTRY (SEMESTER II) SUB.CODE:

CREDITS : 3

UNIT I -PHYSICAL ASPECTS OF PHOTOCHEMISTRY

TEACHING HOURS:60 (15 hours)

Absorptions and emission of radiation- Franc- Condon Principle- decay of electronically excited states- radiative processes, Jablonski diagram fluorescence and phosphorescence, spin forbidden radiative transition, internal conversion and intersystem crossing,- energy transfer process. UNIT-II

(15 hours) Kinetics of unimolecular and bimolecular photo physical process, excimers and exciplexes-

static and dynamic quenching, Stern Volmer analysis. Experimental methods- Standardization of intensity of light sources, quqntum yield, and measurement quantum yield and chemical actinometry. Study of fast reactions- flash photolysis. UNIT-III Organic Photochemistry

(15 hours)

General principles – Photochemistry of carbonyl compounds – Norrish type I and Norrish type II reactions – Photo oxidation, photo reduction – Paterno Buchi, di – pi – methane rearrangement, Barton rearrangement, - cheletropic reactions - cis – trans isomerisation – Photochemistry of arenes. UNIT-IV Inorganic Photochemistry

(15 hours)

Introduction – Mechanism – Photochemistry of Cr3+. Photoredox, photoisomerisation and photosubstitution reaction in coordination chemistry- photovoltaic and photo galvanic cell. Text Books 1.

N.J.Turro, 1978, Modern Molecular Photochemistry, Benjamin, Cummings,

Menlo Park, California. 2.

K.K.Rohatgi Mukherjee, 1978, Fundamentals of Photochemistry, Wiley Eastern Ltd.

3.

S.Glasstone, Source Book of Atomic energy.

4.

H.Depuy & Orville, Molecular reaction and Photochemistry, Charles, L.Chapman, Prentice Hall of India Pvt.Ltd., New Delhi.

5.

Advanced Organic Chemistry, Jerry March, McGraw Hill.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY

M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) SUBJECT – ORGANIC CHEMISTRY-III Code:

CREDITS: 4

TEACHING HOURS: 75

OBJECTIVES OF THE COURSE: This paper explains the instrumental methods of organic structure determination and their application. The second part consists of study of orbital symmetry which forms the basis of many organic synthesis. The last part of the subject deals with aromaticity. UNIT I: Spectroscopy I 1.1

(15 hours)

Principles and application of UV and visible, IR spectroscopy in organic structure determination.

Woodward Fischer rule to calculate λ max. 1.2

NMR spectroscopy. Proton chemical shift, spin-spin coupling constants and application to

organic molecules. FT NMR,

13

C

resonance spectroscopy Origin of non- fisrt order spectrum.

Elementary treatment of FT NMR. UNIT II: Spectroscopy II

(15 hours)

2.1

Mass spectrometry and its application

2.2

ORD and its applications: Cotton effect, axial halo ketone rule and Octant rule

2.3

Problems solving approach (for molecules with a maximum of ten carbons).

UNIT III: Pericyclic reactions 3.1

(15 hours)

Pericyclic reactions: Classification –Orbital symmetry –Woodward Hoffman rules. FMO analysis of electro cyclic, cycloaddition and sigmatrophic reactions.

3.2

Correlation diagrams for Butadiene

cyclobutene and hexatriene

cyclohexadiene inter conversion; (π2s + π2s) and (π2s + π4s) cycloaddition reaction.

3.3

Cope and Claisen rearrangements

Unit IV: Aromaticity 4.1

(15 hours)

Benzenoid and non benzenoid compounds, Huckel and Craig rules. Alternant and non - alternant hydrocarbons, homo aromatic, non – aromatic and anti-aromatic compounds.

4.2

Study of Cyclopropenium cation, Cyclopentadineyl anion, Cycloheptatrienyl cation, ferrocene, pyrene, annulenes [10], [14], [16], [18], [22], Tropolone, azulene.

Unit V: Chemistry of Amino Acids and Proteins

(15 hours)

Amino acids : Various classifications, essential amino acids, physical properties (amphoteric nature and iso electric point) and reactions. Proteins: Classifications based on shape, composition and solubility, physical properties. Primary structure – end group analysis (N- terminal analysis – Edman’s method, Dansyl chloride method; C- terminal analysis – hydrazinolysis and bio – chemical methods Biological functions of proteins, deamination, transamination reactions urea cycle. Text books 1.

R. M. Silverstien, G. C. Bassler & Morril, 1991, Spectrometric Identification of Organic Compounds, 5th Edition, John Wiley & Sons, NewYork.

2.

I. L. Finar, 1986, Organic Chemistry, Vol. II, 5th edition, ELBS Publications.

3.

J.March, 1992, Advanced Organic Chemistry, 4th edition, John Wiley & Sons, Singapore.

4.

P.S Kalsi, 2002, Spectroscopy of Organic Compounds, Wiley Eastern Ltd., Chennai.

6.

F.A.Carey and R.J.Sundberg, 2001, Advanced Organic Chemistry, 4th edition, Plenum Press, New York.

7.

Biochemistry C.B.Powar & G.R.Chatwal

8.

Elements of Biochemistry Ragunatha Rao

9.

Essential Biochemistry U.Sathyanarayana.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY

M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) INORGANIC CHEMISTRY –III CODE:

CREDITS:

TEACHING HOU RS: 75

Objectives of the course: This paper exposes the student to the bonding in Organo metallic compounds and industrial applications of these compounds. This paper deals about spectroscopy and their applications to inorganic compounds. Unit I - Organo metallic chemistry

(20 Hrs)

Carnon donors: Alkyl donors and aryl donors, Metallation, Bonding in carbonyls and nitrosyls, chain and cyclic donors, Olefin (Zeise’s salt), acetylene and allyl (mono hapto, tri hapto, penta hapto complexes) systems. Synthesis, structure and bonding of metallocenes (Ferrocenes). Reacations: Association, substitution, addition and elimination, ligand protanation, electrophilic and nucleophilic attack on ligands, carbonylation and decarbonylation, oxidative addition, fluxionality. Unit II- Industrial applications of Organo metallic compounds

(10 Hrs)

C-C bonds formation (Heck reaction only), Hydrogenation of olefins (Wilkinson catalyst), Hydroformylation of olefins, Cobalt rhodium catalyst (Oxo process), Oxidation of olefins to aldehydes and ketones (Wacker process), polymerization (Ziegler-Natta catalyst), Cyclo oligomerisation of acetylene using nickel catalyst (Reppe’s catalyst), Polymer bound catalysts. Unit III- Inorganic spectroscopy – I

31

(15 Hrs)

Applications to Inorganic system of the following: NMR, NQR and Mossbauer spectra – NMR of P, F, NMR Shift reagents, NQR – Nitrosyls compounds, Mossbauer of Fe and Sn systems. 19

Unit IV- Inorganic spectroscopy – II

(15 Hrs)

ESR introduction – Zeeman equation, g-value, nuclear hyper fine splitting, interpretations of spectrum, simple carbon centered free radicals. Anisotropy – g value and hyper fine splitting constant. Mc Connel’s equation, Kramers theorem, ESR of transition metal complexes of copper, manganese and vanadyl complexes. Photo electron spectroscopy (UV and X-ray) – Koopman’s theorem, fine structure in PES, chemical shift and correlation with electronic charges.

Unit V- Inorganic spectroscopy – III

(10 Hrs)

Ultraviolet – Visible, IR and Raman spectroscopy – Application to inorganic compounds. SEM, TEM – Theory and applications.

Text Books: 1. K.F. Purcell and J.C. Kotz, 1977, Inorganic Chemistry – WB Saunders Co., USA. 2. F.A. Cotton and G. Wilkinson, 1988, Advanced Inorganic Chemistry – A Comprehensive Text, V. Edition, John Wiley & Sons, New York. 3. R. Drago, 1968, Physical method in Inorganic Chemistry, Reinhold, New York. 4.E.A.V. Elbesworth, D. WH. Rankin and S. Crackdock, 1987, Structural methods in Inorganic Chemistry, Blackwell Scientific Publishers. Suggested reference books: 1. G. Coates, M.L. Green and K. Wade, 1988, Principles of Organo Metallic Chemistry, Methven Co., London. 2. R.B. Jordon, 1991, Reaction Mechanisms of Inorganic and Organo Metallic Systems, Oxford University Press. 3. P. Powell, 1988, Principles of Organo Metallic Chemistry, Chapman and Hall. 4. R. C. Mehothra, A. Singh, 1992, Organo Metallic Chemistry, Wiley Eastern Co. 5. C.N.R. Rao, J.R. Ferraro, 1970, Spectroscopy in Inorganic Chemistry, Vol. I and Vol. II, Academic Press. 6. G. Aruldas, Molecular Structure and Spectroscopy, Prentice Hall.

THE NEW COLLEGE (AUTONOMOUS),CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SEMESTER III -SYLLABUS

(Effective from 2009-2010) PHYSICAL CHEMISTRY –III CODE:

CREDITS:

TEACHING HOURS: 75

OBJECTIVES : To learn the basic concepts of chemical kinetics, statistical thermodynamics, and electrochemistry. UNIT I: Chemical Kinetics I

(15 Hours)

Thermal gas phase combination of H2 and Br2. Effect of temperature on reaction rates. Probability of activation. Activation energies for forward and backward reactions. Collision theory of bimolecular and unimolecular reactions. Lindemann’s mechanism for gas phase reactions involving non-reactant molecules. Activation energies from Arrhenius equation and collision theory. Steric factor in collisions. Partition functions. Conventional transition state theory. Evaluation of thermodynamic parameters of activation. Physical significance of entropy, enthalpy and free energy of activation. Hammett and Taft equations (No derivations) Significance of σ and ρ in Hammett equation. Bronsted catalysis – Linear Gibbs free energy relationships. Acid – base catalysis. Kinetic isotope effect – Primary and Secondary effects – Molecular beams. UNIT II: Chemical Kinetics II

(15 Hours)

Solvation of ions and Electrostriction, Entropy and Volume of activation, Effect of dielectric constant, ionic strength and hydrostatic pressure on reaction rates – a qualitative discussion with suitable examples.

UNIT III: Electrochemistry-I

(15 Hours)

Electrochemistry of ions in Solutions : Mean ionic activity and activity coefficient – concept of ionic strength , Debye – Huckel theory of strong electrolytes – activity coefficient of strong electrolytes - Debye – Huckel limiting law – verificationof Debye – Huckel – Bronsted equation.

UNIT IV: Electrochemistry-II

(15 Hours)

Interfacial Electrochemistry: Electrode-Electrolyte interface – Electrical double layerElectrocapillary phenomenon – Lippman equations – structure of electrical double layer – Helmholtz perrin model – Guoy chapmann model and Stern model. UNIT V: Statistical Thermodynamics - I

(15 Hours)

Introduction – Comparison between classical and statistical thermodynamics - Concept of thermodynamics and mathematical probabilities – distribution of distinguishable and non – distinguishable particles – micro and macro state - phase space – Maxwell – Boltzmann, Bose – Einstein statistics and Fermi – Dirac statistics – comparison and applications – modes of contribution to energy – ortho and para hydrogen. Text Books : 1. J.Rajaram and J.C.Kuiracose, Kinetics and Mechanism of Chemical Transformations, McMillan India Ltd., 1993 2. J.Rajaram and J.C.Kuiracose, Thermodynamics for Students of Chemistry, Lal Nagin Chand, New Delhi, 1986 3. M.C.Gupta, Statistical Thermodynamics, Wiley Eastern, New Delhi, 1990. 4. J.O.M.Bokris & A.K.N. Reddy, Electrochemistry, Vols 1 and 2 Plenum, New York, 1997 5. S.Glasstone, Introduction to Electrochemistry, Affiliated East West Press, New Delhi, 1960 Reference : 1. K.J.Laidler, Chemical Kinetics, Harper and Row, New York. 2. S.Glasstone, Thermodynamics for Chemists. Affiliated East West Press, New Delhi, 3. D.R..Crow, Principles and Applications to Electrochemistry , Chapman and Hall, 1991

1960

The New College (Autonomous) Chennai 600014 M.Sc. DEGREE BRANCH – IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) ELECTIVE 4, SUBJECT – INORGANIC CHEMISTRY- PRACTICAL II Code:

CREDITS:

TEACHING HOURS: 90

OBJECTIVES OF THE COURSE: To impart the techniques of analysis of ores, alloys and preparation and analysis of inorganic complex compounds and interpretation of spectra. a) Analysis of Ores: 1. Determination of percentage of calcium and magnesium 2. Determination of percentage of MnO2 in pyrolusite 3. Determination of percentage of tin and lead in solder 4. Determination of copper and zinc in brass 5. Determination of chromium and nickel in stainless steel. b) Analysis of Alloys: 1. Estimation of tin and lead in solder 2. Estimation of copper and zinc in brass 3. Estimation of chromium and nickel in stainless steel c) Analysis of Inorganic Complex Compounds: 1. Preparation of cis and trans potassium bis(oxalate) diaquochromate and analysis of each of these for chromium. 2. Preparation of potassium tris(oxalate) ferrate (III) and analysis for iron and oxalate. d) Quantitative analysis: Quantitative analysis of mixtures of iron and magnesium, iron and nickel, copper and nickel & copper and zinc.

e) Colorimetric analysis: Estimation of iron, nickel, manganese and copper f) Biamperometric titrations: Thiosulphate – iodine system and iron(II) – cerium(IV) system. g) List of spectra to tbe given for interpretation. 1.

31

2.

31

3.

31

P NMR spectra of methylphosphate

P NMR spectra of HPF2 P NMR spectra of ClF3__

4. 1H NMR spectra of Tris (ethylthioacetoacetanato) cobalt (III) 5. Expanded high resolution 1H NMR spectra of (N- propylisonitrosoacetylacetoneiminatio) (acetylacetoneiminato) Nickel (II) 6. ESR spectra of the aqueous ON(SO3)22- ion. 7. ESR spectra of the H atoms in CaF2 8. ESR spectra of the [Mn(H2O)6]2+ ion 9. ESR spectra of the bis (salicylaldiminato) copper (II) 10. IR spectra of the sulphato ligand 11. IR spectra of the nitro and nitritopentaminecobalt (III) chloride 12. IR spectra of the dimethylglyoxime ligand and its Nickel (II) complex 13. IR spectra of the carbonyls 14. Mossbauer spectra of FeSO4. 7 H2O 15. Mossbauer spectra of FeCl3 16. Mossbauer spectra of [Fe(CN)6]317. Mossbauer spectra of [Fe(CN)6]4-

THE NEW COLLEGE (AUTONOMOUS),CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SEMESTER IV -SYLLABUS (Effective from 2009-2010) CHEMISTRY OF MACROMOLECULES(ELECTIVE) CODE:

CREDITS:

TEACHING HOURS: 60

OBJECTIVES: i) To learn the methods of preparation of polymers. ii) To learn the properties and degradation of polymers. UNIT I: Water Soluble Polymers and Polymer additives

(15 Hours)

Water

soluble

polymers – introduction, preparation of acrylamide, polyisothiocyanates, biological activity, new developments in water soluble polysaccharides, electrodeposition, water dispersible polymers. Polymer additives – introduction, fillers, plasticizers, UV stabilizers and absorbers, fire retardants, colourents. UNIT II: Kinetics of Polymerisation

(15 Hours)

Polymerisation in homogeneous and heterogeneous phases. Kinetics and mechanism of free radical and ionic polymerization – chain initiation – propagation –termination – chain transfer – inhibition and retardation – living polymers – anionic ring opening polymerisation. UNIT III: Characterization of Polymers

(15 Hours)

Molecular weight determination of polymers – by light scattering method, viscometry, osmometry, gel permeation chromatography, ultra centrifuge. Fabrication of polymers, moulding of polymers, casting of films. Crystallinity of polymers – introduction, fusion temperature, fusion of homopolymers, copolymers, cross-linked polymers, Interpenetrating network (IPN), Glass transition temperature, factors affecting glass transition temperature.

UNIT IV: Polymer Degradation

(15 Hours)

Physical methods used in the study of degradation process – thermal degradation of polymers, oxidative degradation of polymers, photo degradation of polymers, antioxidants and stabilizers, ablation and biodegradation. Text Books 1. J.M.Gowriker – Polymer Chemistry 2. F.W.Billmeyer – Text Book pf Polymer Science, Wiley Interscience, 1984. Reference : 1. N.M.Bikales Polymer Science & Technology 2. G.Odian, Principles of Polymerisation, McGraw Hill Book Co., New York, 1973 3 G.S.Krisnanbaum, Polymer Science Study Guide, Gordon Breach Science Publishing, New York, 1973.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) SUBJECT – ORGANIC CHEMISTRY-IV Code:

CREDITS: 5

TEACHING HOURS: 90

OBJECTIVES OF THE COURSE: This paper introduces the basic mythologies for the synthesis of organic compounds. The second part consists of study of inter conversions of functional groups. Certain organic name reactions and reagents used in organic synthesis also discussed. The last part consists of study about free radical aspects. Unit I: Modern Synthetic Methodology

(15 hours)

Retero synthetic analysis – synthons, disconnections of simple molecules and their suitable synthesis. Linear bond polarity, symmetrical and unsymmetrical (Umpolung reactions ), Stereo selectivity in organic synthesis, chemo selectivity and regio-selectivity in organic synthesis, Retero synthesis of target molecules like cubanes, 5 – hexenoic acid and bicyclo (4,1,0)heptan -2- one. Unit II: Functional Group Interconversions

(15 hours)

Functional Group Interconversion (FGI) reactions like reduction, oxidation, protection and deprotection of functional groups like carbonyls, hydroxy, amine, carboxylic acids and olefins. Unit III: Organic Name Reactions

(15 hours)

Carbon – carbon bond formation reaction like Robinson’s

annulation reaction, Shapiro

reaction, Ene reaction, Hoffmann – Loffler – Freytag reaction, Stork enamine reaction, Sharpless epoxidation, Passerini Reaction, Polonovski reactions,

Pechmann Condensation, Stille coupling

reaction, Glaser oxidative coupling reaction, Baylis- Hillman Reaction, Biginelli reaction.

Unit IV: Uses of Reagents in Organic Synthesis

(15 hours)

Uses of following reagents in organic synthesis – DIBAL, RED-Al, Gilman’s reagent, Lithium diisopropylamide, trimethylsilyl iodide, trimethylsilyl chloride, n-Bu3SnH, DDQ, Wilkinson’s catalyst, n – butyl lithium, Pd(OAc)2 and Pd(PPh3)4 . Unit V: Free Radical Reactions

(15 hours)

Long lived and short lived free radicals, methods of generation of free radicals. Addition of free radicals to olefinic double bonds. The following aromatic radical substituents are to be studied: Decomposition of diazo compounds, phenols – coupling – Sandmeyer reaction – Gomberg – Bachmann reaction, Pschorr reaction, Ullmann reaction, mechanism of Hunsdiecker reaction – detection of free radicals by ESR. Unit-VI: Modern Techniques in Synthetic Organic Chemistry

(15 hours)

4.1 Microwave induced organic synthesis – introduction – microwave oven – reaction vessels – reaction medium – advantages – limitations – precautions. 4.2 Applications: Esterification – reaction of carboxylic acid and benzyl ether using LnBr2, Deacetylation – deacetylation of acetylated phenols, Fries rearrangement, ortho ester Claisen rearrangement, Diels – Alder reaction.

Text books 1. B. I. Smith, 1980, Organic synthesis, Chapman and Hall, New York. 2. A. Francis Carey, Richard. J. Sundberg, 2001, Advanced Organic Chemistry, 4 th edition, Plenum Press, New York. 3. R. K. Mackie and D. M. Smith, 1998, Guide Book to Organic Synthesis, ELBS Publications. 4. I. L. Finar, 1986, Organic Chemistry, 5th edition, Volume II, ELBS Publications. 5. Bradford .P.Mundy, Michael.G.Ellerd & Frank.G.Favalaro, 2005, Name Reactions & Reagents in Organic Synthesis, 2nd edition, Wiley – Interscience.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI – 14 PG & RESEARCH DEPARTMENT OF CHEMISTRY M.Sc., DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) INORGANIC CHEMISTRY –IV CODE:

CREDITS:

TEACHING HOURS: 90

Objectives of the course: This paper exposes student to understand the basic concepts of nano chemistry which is being recognized as one of the emerging field. This paper also include nuclear chemistry, transition elements, and environmental chemistry. Unit I- Nano Chemistry

(30 Hrs)

Soft chemical procedures. Synthesis of nano crystalline oxides – Al2O3,, Fe2 O3, CeO2, ZnO2 and TiO2. Salvothermal synthesis – InS3, CdSe and CdTe. Quantum dots(QDS) – Synthesis of supra molecular caged clusters and core – shell nano particles. Characterization techniques: XRD, HRTEM, TPD, LRS, Photo luminescent spectra. Unit II- The chemistry of the transition elements I

(15 Hrs)

The elements of the first transition series – Titanium, vanadium and chromium compounds – halides, oxo salts and their organometallic compounds. Unit III- The chemistry of the transition elements I I

(15 Hrs)

The elements of the Second and third transition series – Zirconium and hafnium – Halides, oxides and their organometallic compounds – zirconium clusters. Niobium and tantalum – cluster and organometallic compounds. Unit IV - Nuclear Chemistry - I

(15 Hrs)

Nuclear properties: Nuclear spin and moments, origin of nuclear forces, salient features of the liquid drop and the shell models of the nucleus.

Modes of radioactive decay: Orbital electron capture, nuclear isomerism, internal conversion, detection and determination of activity by cloud chamber, nuclear emulsion, bubble chamber, G.M., Scintillation and Cherenkov counters. Unit V-: Nuclear Chemistry - II

(15 Hrs)

Nuclear reaction: Types, reactions cross section, Q-value, threshold energy, compound nucleus theory: high energy nuclear reactions, nuclear fission and fusion reactions as energy sources; direct reactions, photonuclear and thermounuclear reactions. Stellar energy: Synthesis of elements, hydrogen bonding. Carbon burning: The e, s, r, p and x process. Unit VI- Environmental Chemistry

(10 Hrs)

Water Quality Standards, BOD, COD. Ambient air quality standards: Photochemical smog, oxides of nitrogen Toxic Chemicals in environmental: LD50, Toxicity of Hg, Pb, Cr. Analytical Methods in Environmental toxins. Text Books: T. Pradeep, Nano the essentials: Understanding annoscience and nanotechnology. Tata McGraw-Hill publishing company Limited, New Delhi. 2. H.J. Arnikar, Nuclear Chemistry, Wiley Eastern Co., II Edition, 1987. 3. C.R. Choppin and J. Ryd Berg: Nuclear Chemistry – Theory and Applications, Pergamon Press. 4. B.G. Harvey, Introduction to Nuclear Physics and Chemistry Prentice Hall, 1962. 5. D.A. Skoog, 1985, Principles of Instrumental methods of Analysis, III Edition, Saunders College Publication. 6. Willard Merrit, Dean and Settle, 1986, Instrumental methods of Analysis, VI Edition, CBS Publication. 7. C.R. Choppin and J. Ryd Berg: Nuclear Chemistry – Theory and Applications, Pergamon Press.

8. B.G. Harvey, Introduction to Nuclear Physics and Chemistry Prentice Hall, 1962. Suggested reference books: 1. Huheey, 1993, Inorganic Chemistry – Principles, Structure and Reactivity; IV Edition, Harper Collins, NY. 2. F.A. Cotton and G. Wilkinson, 1988, Advanced Inorganic Chemistry – A Comprehensive Text, V. Edition, John Wiley & Sons. 3. K.F. Purcell and J.C. Kotz, 1977, Inorganic Chemistry – WB Saunders Co., USA. 4. S. Glasstons, Source Book on Atomic Energy, Van Nostrand Co., 1969. 5. G. Frielander, J.W. Kennady and J.M. Miller, Nuclear and Radiochemistry, John Wiley and Sons, 1964.

THE NEW COLLEGE (AUTONOMOUS),CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SEMESTER IV SYLLABUS (Effective from 2009-2010) PHYSICAL CHEMISTRY –IV(SEMESTER IV) CODE:

CREDITS:4

TEACHING HOURS: 90

OBJECTIVES : To learn the concepts of Chemical kinetics, statistical thermodynamics, and electrochemistry. UNIT I: Chemical Kinetics III

(15 Hours)

Enzyme Catalysis: Effect of substrate concentration on reaction rates. Graphical analysis of rate versus – substrate concentration. Lineweaver – Burk and Eadie plots. Michaelis – Menten mechanism involving more than one sequential intermediate. Influence of pH on rate. (No derivation of rate equation). Influence of temperature on rate. Inhibition of enzyme catalysed reactions UNIT II: Chemical Kinetics IV

(15 hours)

Complex reactions: kinetics of consecutive, reversible, parallel and chain reactions. Chain lengthDecomposition of N2O5. Ortho - para hydrogen conversion.

Explosion limits. Rice-Herzfeld

mechanisms. UNIT III

(15 hours)

Surface reactions: Langmuir adsorption isotherm-Determination of adsorption physical significance. Types of adsorption reactions in heterogeneous

coefficient and its catalysis. Langmuir –

Hinshelwood, Rideal – Eley and Temkin – Pyzhev mechanisms. Surface catalysed hydrogenation of ethylene. Brunauer Emmet –Teller equation (BET) (no derivation) UNIT IV: Electrochemistry-III :

(15Hours)

Electrodics : Mechanism of single electrode reaction – Polarization and over potential – the Butler – Volmer equation for single step and multistep electron transfer reactions – significance of

exchange current density and symmetry factor – Nernst and Tafal equation- transfer coefficient and oxygen evolution reaction. UNIT V: Electrochemistry IV

(15 Hours)

Electrokinetic phenomena: Electrokinetic properties-origin of Electro osmosis, Steaming current, Electrophoresis-Atomistic interpretation of Electro kinetic phenomena Corrosion and passivation of metals-Pourbaix diagram-Evan’s diagram-Electrochemical synthesis. UNIT VI : Statistical Thermodynamics - II

(15 Hours)

Partition function – evaluation of translational, vibrational and rotational partition functions for mono, diatomic and polyatomic ideal gases- relation between partition function and thermodynamic quantities E,H,G,A,P,Cv and Cp – Energy of monoatomic gas – III law of thermodynamics _ Entropy of ideal gas – Sackur Tetrode equation – metallic bond – electron gas model – Dulong Petit’s law – T3 equation.. Text Books 1. M.C.Gupta, Statistical Thermodynamics, Wiley Eastern, New Delhi, 1990. 2. J.Rajaram and J.C.Kuiracose, Kinetics and Mechanism of Chemical Transformations, McMillan India Ltd., 1993. 3. J.O.M.Bokris & A.K.N. Reddy, Electrochemistry, Vols 1 and 2 Plenum, New York, 1997 4. S.Glasstone, Introduction to Electrochemistry, Affiliated East West Press, New Delhi,1960 Reference: 1. K.J.Laidler, Chemical Kinetics, Harper and Row, New York. 2. K.L.Kapoor, A Text Book of Physical Chemistry, Macmillan India Ltd, 2001 3. D.R..Crow, Principles and Applications to Electrochemistry , Chapman and Hall,1991 4. P.W.Atkins, Physical Chemistry , Oxford University Press

THE NEW COLLEGE (AUTONOMOUS), CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the year 2009-2010) INSTRUMENTAL METHODS OF ANALYSIS( SEMESTER IV) CODE:

CREDITS: 3

Unit – I

TEACHING HOURS: 60 (15 hours)

1.1. Electronics: Basic functions of instrumentation – Semiconductor components – operational amplifiers – Signal to noise ratio – Sources of noise – instrument calibration. 1.2. Optical methods of analysis: Colorimetric, UV – Visible spectrometric and IR analysis – single and double beam instruments – sampling techniques – working- Laser types and techniques. Raman spectroscopy – basic instrumentation and working of Mass, NMR & ESR Spectrometers.

Unit – II

(15 hours)

2.1. Ion exchange Chromatography: Instrumentation 2.2. Gas liquid chromatography – instrumentation, carrier gas columns, stationary phase, Detectors, Thermal conductivity, Flameionisation, Electron capture. 2.3. High Performance liquid chromatography – instrumentation, pumping systems, Columns, column packing, detectors. 2.4. Electrophoresis – instrumentation –application Unit – III

(15 hours)

3.1. Polarography - theory, Instrumentation, DME, Diffusion, Kinetic and catalytic currents, currentvoltage curves for reversible and irreversible system, qualitative and quantitative applications. 3.2. Pulse polarography – Square wave polarography – cyclic voltammetry – theory, Instrumentation and applications to Inorganic systems. 3.3. Amperometric titrations- theory, instrumentation, type of titration curves, successive titrations and indicator electrode - Applications- Biamperometry, potentiometry, Bipotentiometry.

Unit – IV

(15 hours)

4.1 Atomic absorption spectroscopy: Theory, atomizers, Flame and electrochemical radiation sources, Instrumentation, Spectral and Chemical Interferences, applications.

4.2. Photoelectron spectroscopy (UV and X - ray) - Photoelectron, Spectro Koopman’s theorem, fine structure in PES, Chemical shift and correlation with electronic charges. 4.3. Radio analytical methods – Isotope dilution analysis, radiometric titrations – Radio Immuno assay – Neutron activation analysis. 4.4 Magnetic susceptibility and measurements – Guoy method, Faraday method – applications. Reference: 1. D.A. Skoog, 1985, Principles of Instrumental Methods of Analysis. III Edition, Saunders College Publication. 2. Willard Merit, Dean and Settle, 1986, Instrumental Methods of Analysis, VI Edition, CBCS publication, 3. A.I. Vogel, 1985, 1976, Textbook of Quantitative Inorganic Analysis, ELBS III Editionand VI Edition 4. D.A Skoog and D.M. West.1982, Fundamentals of Analytical Chemistry, IV Edition and VI Edition 5. D.A. Skoog and D.M.West, 1982 Fundamentals of Analytical Chemistry, IV Edition, Holt Reinheart and Winston Publication. 6. K.V. Raman, 1993, Computers in Chemistry, Tata McGraw Hill, New Delhi. Other Reference Books Suggested 1. 2. 3. 4. 5.

G.D. Christian & J.E.O. Reilly, 1986 Instrumental Analysis II Edition, Allen Becon. H.A. Storbital, 1976, Chemical Instrumentation, Addition – Wesley Publication Co. Wilson and Wilson Series, Comprehensive Analytical Chemistry. R.C. Kapoor And B.S. Agarwal, Ms.1991, Principles Of Polarography, Wiley Eastern Limited K. Ebert, H.Ederes And T.L Isenhowr, Computer Applications In Chemistry,VCH.0.

THE NEW COLLEGE(AUTONOMOUS), CHENNAI-600 014 PG & RESEARCH DEPARTMENT OF CHEMISTRY (CBCS SYLLABUS FOR 2008-2009 BATCH) PHYSICAL CHEMISTRY-III,(SEMESTER IV) TEACHING HOURS :90 CREDITS :4 SUB.CODE:

UNIT I

(18 Hours)

Vibrationals spectroscopy-Harmonic and anharmonic oscillator frequency ωosc position of spectral line in terms of ωosc –Condition for IR activity –vibrational –rotational spectra of diatomic moleculeorigin of P,Q and R branches-vibrational spectra of polyatomic molecules-vibrational coupling overtones-Fermi resonance-Raman spectra-criteria for a molecule to be Raman active-pure Raman spectra and vibrational Raman spectra. Electronic spectroscopy: Types of Electronic transitions-Frank condon principle-predissociation-Effect of conjucation and solvent on electronic transitions. UNIT II

(18 Hours)

Nuclear Magnetic Resonance spectroscopy : Angular and magnetic motion of nucleus –Larmor frequency-Relaxation process-Relaxation time and its effect on line width-chemical shift-spin-spin coupling-coupling constant-NMR spectrum of simple A-X and AMX type molecules-FT NMR(Elementary idea)-C13 NMR- double resonance spectroscopy UNIT III

Electrochemistry-II

(18Hours)

Electrodics Electrodics : Mechanism of single electrode reaction – Polarization and overpotential – the Butler – Volmer equation for single step and multistep electron transfer reactions – significance of exchange current density and symmetry factor – Nernst and Tafal equation- transfer coefficient and oxygen evolution reaction.

UNIT IV

(18Hours)

Electrokinetic phenomena: Electrokinetic properties-origin of Electro osmosis, Steaming current, Electrophoresis-Atomistic interpretation of Electro kinetic phenomena Corrosion and passivation of metals-Pourbaix diagram-Evan’s diagram-Electrochemical synthesis. UNIT V

(18 Hours)

Photo Chemistry Absorption and emission of radiation –Frank –Condon Principle-decay of electronically excited states – radiative Process, fluorescence and phosphorescence, spin forbidden transition, internal conversion and intersystem crossing-energy transfer process, Kinetics of unimolecular and bimolecular photophysical process, excimers and exiplexes- static and dynamic quenching, Stern Volmer analysis. TEXT BOOKS 1. J.Raja ram and J.C.Kuiracose, Kinetics and mechanism of chemical Transformations, McMillan India Ltd., 1993 2. K.J.Laidler, Chemical kinetics,Harper and Row, New York. 3. K.L.Kapoor, A Text Book of Physical Chemistry,Macmillan India Ltd, 2001 4. P.W.Atkins, Physical Chemistry , Oxford University Press. 5. D.A.McQuarrie, Quantum Chemistry, University Science Books, Mil Valley,California, 1983. 6. I.N.Levine , Quantum Chemistry, Allyn and Bacon,Boston, 1983 7. R.Anatharaman, Fundamentals of Quantum Chemistry, McMillan India Ltd., 2001 8. R.K.Prasad, Quantum Chemistry, New Age Publication, India, 1992 9. C.N.Banwell, Fundamendals of Molecular Spectroscopy, Tata McGraw Hill, 2003 10. G.Aruldas, Molecular Structure and Spectroscopy, Prentice Hall, 2002. 11 S.Glasstone, Thermodynamics for Chemists. Affiliated East West Press, New Delhi, 1960 12 J.Rajaram and J.C.Kuiracose, Thermodynamics for Students of chemistry, Lal Nagin Chand, New Delhi, 1986 13 K.V.Raman, Group theory and its applications of Chemistry, Tata McGraw Hill, 1990.

REFERENCES 1.W.J.Moore, Physical Chemistry, Orient Longman, London, 1972. 2.G.M.Barrow, Physical Chemistry, McGraw Hill, 1988. R.G.Frost and Pearson, Kinetics and Mechanism,

THE NEW COLLEGE (AUTONOMOUS), CHENNAI-600 014 M.Sc DEGREE: BRANCH –IV CHEMISTRY CBCS SYLLABUS (Effective from the academic year 2008-2009) ( SEMESTER III ) CORE 10, INORGANIC CHEMISTRY –II CODE:

CREDITS:4

TEACHING HOURS: 75

Objectives of the course: This paper exposes the student to the bonding in Organo metallic compounds and industrial applications of these compounds. This paper deals about spectroscopy and their applications to inorganic compounds. Unit I - Organo metallic chemistry

(20 Hrs)

Carnon donors: Alkyl donors and aryl donors, Metallation, Bonding in carbonyls and nitrosyls, chain and cyclic donors, Olefin (Zeise’s salt), acetylene and allyl (mono hapto, tri hapto, penta hapto complexes) systems. Synthesis, structure and bonding of metallocenes (Ferrocenes). Reacations: Association, substitution, addition and elimination, ligand protanation, electrophilic and nucleophilic attack on ligands, carbonylation and decarbonylation, oxidative addition. Unit II - Industrial applications of Organo metallic compounds

(15 Hrs)

C-C bonds formation (Heck reaction only), Hydrogenation of olefins (Wilkinson catalyst), Hydroformylation of olefins, Cobalt rhodium catalyst (Oxo process), Oxidation of olefins to aldehydes and ketones (Wacker process), polymerization (Ziegler-Natta catalyst), Cyclo oligomerisation of acetylene using nickel catalyst (Reppe’s catalyst), Polymer bound catalysts. Unit III - Inorganic spectroscopy – I

(15 Hrs)

Applications to Inorganic system of the following: NMR- PMR, NMR of 31P, 19F, Basic Principles and Elementary applications of NQR and Mossbauer Spectra . Unit IV - Inorganic spectroscopy – II

(15 Hrs)

ESR introduction – Zeeman equation, g-value, nuclear hyper fine splitting, interpretations of spectrum, simple carbon centered free radicals. Anisotropy – g value and hyper fine splitting constant.

Mc Connell’s equation, Kramers theorem, ESR of transition metal complexes of copper, manganese and vanadyl complexes. Unit V - Inorganic spectroscopy – III

(10 Hrs)

Ultraviolet – Visible, IR and Raman spectroscopy – Application to inorganic compounds SEM, TEM – Theory and applications. Text Books: 1. K.F. Purcell and J.C. Kotz, 1977, Inorganic Chemistry – WB Saunders Co., USA. 2. F.A. Cotton and G. Wilkinson, 1988, Advanced Inorganic Chemistry – A Comprehensive Text, V. Edition, John Wiley & Sons, New York. 3. R. Drago, 1968, Physical method in Inorganic Chemistry, Reinhold, New York. 4. E.A.V. Elbesworth, D. WH. Rankin and S. Crackdock, 1987, Structural methods in Inorganic Chemistry, Blackwell Scientific Publishers. Suggested reference books: 1. G. Coates, M.L. Green and K. Wade, 1988, Principles of Organo Metallic Chemistry, Methven Co., London. 2. R.B. Jordon, 1991, Reaction Mechanisms of Inorganic and Organo Metallic Systems, Oxford University Press. 3. P. Powell, 1988, Principles of Organo Metallic Chemistry, Chapman and Hall. 4. R. C. Mehothra, A. Singh, 1992, Organo Metallic Chemistry, Wiley Eastern Co. 5. C.N.R. Rao, J.R. Ferraro, 1970, Spectroscopy in Inorganic Chemistry, Vol. I and Vol. II, Academic Press.

The New College (Autonomous) Chennai 600014 M.Sc. DEGREE BRANCH – IV CHEMISTRY SYLLABUS (Effective from the academic year 2009-2010) CORE 12, SUBJECT – INORGANIC CHEMISTRY- PRACTICAL II Code:

CREDITS:

TEACHING HOURS: 90

OBJECTIVES OF THE COURSE: To impart the techniques of analysis of ores, alloys and preparation and analysis of inorganic complex compounds and interpretation of spectra. a) Analysis of Ores: 1. Determination of percentage of calcium and magnesium 2. Determination of percentage of MnO2 in pyrolusite 3. Determination of percentage of tin and lead in solder 4. Determination of copper and zinc in brass 5. Determination of chromium and nickel in stainless steel. b) Analysis of Alloys: 1. Estimation of tin and lead in solder 2. Estimation of copper and zinc in brass 3. Estimation of chromium and nickel in stainless steel c) Analysis of Inorganic Complex Compounds: 1. Preparation of cis and trans potassium bis(oxalate) diaquochromate and analysis of each of these for chromium. 2. Preparation of potassium tris(oxalate) ferrate (III) and analysis for iron and oxalate. d) Quantitative analysis: Quantitative analysis of mixtures of iron and magnesium, iron and nickel, copper and nickel & copper and zinc.

e) Colorimetric analysis: Estimation of iron, nickel, manganese and copper f) Biamperometric titrations: Thiosulphate – iodine system and iron(II) – cerium(IV) system. g) List of spectra to tbe given for interpretation. 1.

31

2.

31

3.

31

P NMR spectra of methylphosphate

P NMR spectra of HPF2 P NMR spectra of ClF3__

4. 1H NMR spectra of Tris (ethylthioacetoacetanato) cobalt (III) 5. Expanded high resolution 1H NMR spectra of (N- propylisonitrosoacetylacetoneiminatio) (acetylacetoneiminato) Nickel (II) 6. ESR spectra of the aqueous ON(SO3)22- ion. 7. ESR spectra of the H atoms in CaF2 8. ESR spectra of the [Mn(H2O)6]2+ ion 9. ESR spectra of the bis (salicylaldiminato) copper (II) 10. IR spectra of the sulphato ligand 11. IR spectra of the nitro and nitritopentaminecobalt (III) chloride 12. IR spectra of the dimethylglyoxime ligand and its Nickel (II) complex 13. IR spectra of the carbonyls 14. Mossbauer spectra of FeSO4. 7 H2O 15. Mossbauer spectra of FeCl3 16. Mossbauer spectra of [Fe(CN)6]317. Mossbauer spectra of [Fe(CN)6]4-

THE NEW COLLEGE(AUTONOMOUS), CHENNAI-600 014 PG & RESEARCH DEPARTMENT OF CHEMISTRY (CBCS SYLLABUS FOR 2008-2009 BATCH) E 4, SPECIAL TOPICS IN PHYSICAL CHEMISTRY

SUB.CODE: UNIT I: Quantum Chemistry –III

CREDITS

TEACHING HOURS :60 (15 Hours)

Perturbation and variation methods- application to hydrogen, helium atoms. Born –Oppenheimer approximation-valence bond theory for Hydrogen molecule-LCAO-MO theory fpr di and polyatomic molecules-concepts of hybridization-Huckel theory for conjucated molecules(ethylene, butadiene and benzene)-semi empirical methods. UNIT II:

Statistical Thermodynamics-II

(15 Hours)

Energy of monoatomic gas –III law of themodynamics-Energy of ideal gas-Sackur Tetrode equation. Bose- Einstein statistics.Fermi-Dirac statistics.Metallic bond-electron gas model-Dulong-petits law-T3 equation. UNIT III:Spectroscopy-I

(15 Hours)

General features of spectroscopy-Electromagnetic radiation-Characteristics of radiations, regions of spectrum – Types of molecular energies-Quantization of energy-interaction of radiation with matterconditions for adsorption and emission-line and band spectrum-factors affecting width and intensity of spectral lines. Rotational spectroscopy-Rotational energy in terms of molecular parameters-line spacing in terms of Rotational constant “B”-calculation of bond length-rigid and non rigid rotor-diatomic and triatomic molecules-effect of isotopic substitution. UNIT IV :Electrochemistry-I

(15 Hours)

. Interfacial Electrochemistry: Electrode-Electrolyte interface – Electrical double layer-Electrocapillary phenomenon – Lippman equations – structure of electri cal doble layer – Helmholtz perrin model – Guoy chapmann model and Stern model.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI M.SC. DEGREE BRANCH – IV CHEMISTRY SYLLABUS WEF: 2008-2009 ( SEMESTER III) EDE 2,SELECTED ADVANCED TOPICS IN CHEMISTRY SUB. CODE:

TEACHING HOURS

UNITS-I Nuclear Chemistry –I

: 60

CREDITS: 3 (15hrs)

Stability of nucleus – Factors affecting the stability-Nuclear forces, Theories of nuclear forcesnuclear Models-Shell Models-nuclear potential (only square-well potential), Liquid drop model- Merits and demerits of the models. Models of radioactive decay-orbital electron capture, positron emission, nuclear isomerism, internal conversion-detection and determination of activity by cloud chamber, nuclear emulsion, bubble chamber, G.M., Scintillation and cherenkov counters. Accelerations – Linear Accelerators, cyclic accelerators, principle of phase stability, synchrocyclotron. UNITS-II Nuclear Chemistry-II

(15 hrs)

Nuclear reaction – types, reactions, cross section, Q-value, threshold energy, compound nucleus theory. Nuclear fission and its characteristics – mass, charge, and ionic charge distribution of fragments in fission reaction, fission cross section – fission energy, theory of nuclear fissions. Fusion reactions as energy sources-direciton reactions, photonuclear and thermo nuclear reactions. Components of nuclear reactors- the breeder reactor – nuclear reactors in India. Unit-III Food Chemistry –-Enzymes

(15 hrs)

Chemical Nature of Enzymes. Catalysis-enzyme kinetic, steady state rate kinetics and reaction order. Nomenclature, classification, typical concentration of enzymes in some food, factors influencing concentration of enzymes in some food. Enzyme Cofactors. Feature of organic cofactors, coenzymes prosthetic group – significance of metallo of enzymes in food chemistry, enzyme inactivation and control, reversible inhibitors, competitive and uncompetitive inhibition. Irreversible inhibitors.

Enzymes as processing aids: production of sweetners, in modifying lipids, in milk and dairy product. Baking for the removal of unwanted constituents, brewing, for control for microorganism. Unit IV Lipids

(15 hrs)

Fatty acids –nomenclature-R/S system and stereospecfic numbering, phospholipids, classification of lipids-mild fats, lauric acids, vegetable butters; simple, compound and derived lipidsoleic and linoleic acids. Modification of fats. Hydrogenation. Oxidation in biological system ; factors influencing rate of lipid oxidation in food. Methods of measuring lipid oxidation- solid fat index, peroxide value, thio barbituric acid test, anisidine value, kresis test, oxirane test and iodine value. Antioxidants: Effectiveness and mechanism of action; synergism-characteristics of commonly used antioxidants. Thermal non-oxidable and oxidable reactions Saturated fats. Reference: Food chemistry Text books 1. O.R. Fennema, food chemistry 3rd Ed, Tata McGraw-Hilll, Newyork, 2003 2. S.S. Nielson, A Chapman and Hall, Food Analysis, Food Science Title, 2nd ., Aspen Publishers, 1998. 3. V.A. Vaclavik and E.W Christien essentials of food science, Third edition, ed., Springer, 2008. 4. Vogel’s Test book of Practical Organic Chemistry,5th Ed., Pearson Education, 2006. 5. B.Srilakshmi, Food science, 3rd Ed., Age intl.publ.2003. Reference books 1. S.Rangamma, manual of analysis of fruits and vegetable products. Tata Mcgraw-Hill Pub.Comp.Ltd., New Delhi, 1977. 2. S.Sivasankar, food processing and preservation, prentice hall of India, New 3. S.J. Lippard, Bioinorganic Chemistry, viva books (p) ltd, 1998. 4. P.K. Battacharya, biochemistry, Narosa publishing House, 2005.

Delhi, 2002

Nuclear Chemistry Text books; 1. C.R. Choppin and J.Ryd Berg: Nuclear chemistry – Theory and Application, pergamon press. 2. G.R. Chopin, Experimental Nuclear Chemistry, Prentice Hall, 1962. 3. C.Kelter, Radio Chemistry, Ellis hardwood Ltd, john Wiley and sons. 4.G.Friedlander, J.W. Kennedy and J.M .Miller, Nuclear and radiochemistry, john Wiley. 5. Arnikar, Essentials of nuclear chemistry, 4th edition, New Age international Publishers ltd, New Delhi.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI-600 014 M.Sc DEGREE: BRANCH –IV CHEMISTRY CBCS SYLLABUS (Effective from the academic year 2008-2009) CORE 13, INORGANIC CHEMISTRY –III CODE:

CREDITS:

TEACHING HOURS :90

Objectives of the course: This paper exposes student to understand the basic concepts of nano chemistry which is being recognized as one of the emerging field. This paper also include Unit I- Nano Chemistry

(30 Hrs)

Soft chemical procedures. Synthesis of nano crystalline oxides – Al2O3,, Fe2 O3, CeO2, ZnO2 and TiO2. Salvothermal synthesis – InS3, CdSe and CdTe. Quantum dots(QDS) – Synthesis of supra molecular caged clusters and core – shell nano particles. Characterization techniques: XRD, HRTEM, TPD, LRS, Photo luminescent spectra. Unit II - The chemistry of solid state

(20 Hrs)

Structure of Solids; Comparison of X-Ray, Neutron and Electron Diffraction; Structure of ZnS, Rutile, Pervoskite, Cadmium Iodide and Nickel Arsenide; Spinels and Inverse Spinels; defects in solids, non-stoichometric compounds. Use of X-Ray powder diffraction data in identifying inorganic crystalline solids, details for cubic systems. Electrical, Magnetic and Optical properties of solids - Band theory, Semiconductors, Superconductors, Solid State Electrolytes, Types of Magnetic Behavior – Dia, Para, Ferro, Antiferro and ferrimagnetism, Hysterisis, Solid State Lasers, Inorganic Phosphorus, Ferrites, Garnets. Reactions in Solid State and Phase Transitions, Diffusion, Diffusion Coefficient, Diffusion Mechanisms, Vacancy and Interstitial Diffusion, Formation of Spinels. Solid Solutions: Order-Disorder Transformations and Super Structure. Unit III - The chemistry of the transition elements I

(10 Hrs)

The elements of the first transition series – Titanium, vanadium and chromium compounds – halides, oxo salts and their organometallic compounds. Unit IV- The chemistry of the transition elements I I

(15 Hrs)

The elements of the Second and third transition series – Zirconium and hafnium – Halides, oxides and their organometallic compounds – zirconium clusters. Niobium and tantalum – cluster and organometallic compounds. Unit V - Inorganic Photochemistry

(15 Hrs)

Introduction – mechanism – Photochemistry of Cr3+, Photoredox, Photosubstitution Reactions in Co-ordination Chemistry.

Photoisomerization and

Photoelectrochemistry – Photovoltaic and Photogalvanic Cells, Aspects of solar energy conversion. Text Books: 1. A.R. West, 1991, Basic Solid State Chemistry, John Wiley. 2. W.E. Addison, 1961, Structural Principles in Inorganic Chemistry, Longman. 3. M. Adams, 1974, Inorganic Solids, John Wiley Sons. 4. S. Glasstone, Source Book on Atomic Energy, East West Press. 5. C.R. Choppin and J. Ryd Berg: Nuclear Chemistry – Theory and Applications, Pergamon Press. 6. D.A. Skoog, 1985, Principles of Instrumental methods of Analysis, III Edition, Saunders College Publication. 7. Willard Merrit, Dean and Settle, 1986, Instrumental methods of Analysis, VI Edition, CBS Publication. 8. C.R. Choppin and J. Ryd Berg: Nuclear Chemistry – Theory and Applications, Pergamon Press. 9. B.G. Harvey, Introduction to Nuclear Physics and Chemistry Prentice Hall,

1962.

Suggested reference books: 1. A.F. Wells, 1984, Structural Inorganic Chemistry, V Edition, Oxford. 2. A.R. West, 1990, Solid State Chemistry, John Wiley. 3. G.D. Christian & J.E.O. Reily, 1986, Instrumental Analysis, II Edition, Allegn Recon. 4. H.A. Strobel, 1976, Chemical Instrumentation, Addition – Wesely Publ. Co. 5. Kolthoff and Elwing (All Series) – Treatise on Analytical Chemistry. 6. Willson Series – Comprehensive Analytical Chemistry. 7. G.R. Chopin, Experimental Nuclear Chemistry, Prentice Hall, 1962. 8. G. Friedlander, J.W. Kennedy, and J.M. Miller, Nuclear and Radio Chemistry, John Wiley 9. F.A. Cotton and G. Wilkinson, 1988, Advanced Inorganic Chemistry – A Comprehensive Text, V. Edition, John Wiley & Sons, New York.

THE NEW COLLEGE(AUTONOMOUS), CHENNAI-600 014 PG & RESEARCH DEPARTMENT OF CHEMISTRY (CBCS SYLLABUS FOR 2008-2009 BATCH) CORE 14, PHYSICAL CHEMISTRY-III,( SEMESTER IV) SUB.CODE:

TEACHING HOURS :90

CREDITS :4

UNIT I (18 Hours) Vibrationals spectroscopy-Harmonic and anharmonic oscillator frequency ωosc position of spectral line in terms of ωosc –Condition for IR activity –vibrational –rotational spectra of diatomic moleculeorigin of P,Q and R branches-vibrational spectra of polyatomic molecules-vibrational coupling overtones-Fermi resonance-Raman spectra-criteria for a molecule to be Raman active-pure Raman spectra and vibrational Raman spectra. Electronic spectroscopy: Types of Electronic transitions-Frank condon principle-predissociation-Effect of conjucation and solvent on electronic transitions. UNIT II

(18 Hours)

Nuclear Magnetic Resonance spectroscopy : Angular and magnetic motion of nucleus –Larmor frequency-Relaxation process-Relaxation time and its effect on line width-chemical shift-spin-spin coupling-coupling constant-NMR spectrum of simple A-X and AMX type molecules-FT NMR(Elementary idea)-C13 NMR- double resonance spectroscopy UNIT III

Electrochemistry-II

(18Hours)

Electrodics Electrodics : Mechanism of single electrode reaction – Polarization and overpotential – the Butler – Volmer equation for single step and multistep electron transfer reactions – significance of exchange current density and symmetry factor – Nernst and Tafal equation- transfer coefficient and oxygen evolution reaction.

UNIT IV

(18 Hours)

Electrokinetic phenomena: Electrokinetic properties-origin of Electro osmosis, Steaming current, Electrophoresis-Atomistic interpretation of Electro kinetic phenomena Corrosion and passivation of metals-Pourbaix diagram-Evan’s diagram-Electrochemical synthesis.

UNIT V

(18 Hours)

Photo Chemistry Absorption and emission of radiation –Frank –Condon Principle-decay of electronically excited states – radiative Process, fluorescence and phosphorescence, spin forbidden transition, internal conversion and intersystem crossing-energy transfer process, Kinetics of unimolecular and bimolecular photophysical process, excimers and exiplexes- static and dynamic quenching, Stern Volmer analysis. TEXT BOOKS 11. J.Raja ram and J.C.Kuiracose, Kinetics and mechanism of chemical Transformations, McMillan India Ltd., 1993 12. K.J.Laidler, Chemical kinetics,Harper and Row, New York. 13. K.L.Kapoor, A Text Book of Physical Chemistry,Macmillan India Ltd, 2001 14. P.W.Atkins, Physical Chemistry , Oxford University Press. 15. D.A.McQuarrie, Quantum Chemistry, University Science Books, Mil Valley,California, 1983. 16. I.N.Levine , Quantum Chemistry, Allyn and Bacon,Boston, 1983 17. R.Anatharaman, Fundamentals of Quantum Chemistry, McMillan India Ltd., 2001 18. R.K.Prasad, Quantum Chemistry, New Age Publication, India, 1992 19. C.N.Banwell, Fundamendals of Molecular Spectroscopy, Tata McGraw Hill, 2003 20. G.Aruldas, Molecular Structure and Spectroscopy, Prentice Hall, 2002.

14 S.Glasstone, Thermodynamics for Chemists. Affiliated East West Press, New Delhi, 1960 15 J.Rajaram and J.C.Kuiracose, Thermodynamics for Students of chemistry, Lal Nagin Chand, New Delhi, 1986 16 K.V.Raman, Group theory and its applications of Chemistry, Tata McGraw Hill, 1990.

REFERENCE 1.W.J.Moore, Physical Chemistry, Orient Longman, London, 1972. 2.G.M.Barrow, Physical Chemistry, McGraw Hill, 1988. 3. R.G.Frost and Pearson, Kinetics and Mechanism,

THE NEW COLLEGE (AUTONOMOUS), CHENNAI-14 M.SC DEGREE: BRANCH- IV CHEMISTRY SYLLABUS (Effective from the academic year 2008-2009 batch)

CORE 15– INSTRUMENTATION METHODS OF ANALYSIS AND RESEARCH METHODOLOGY. CODE:

CREDITS : 5

TEACHING HOURS: 90

OBJECTIVES OF THE COURSE: 1.To learn outlines of electronics and applications 2.To understand the basic principles, instrumentation & applications of chromatography, electroanalytical methods, radioanalytical methods, spectroscopic methods and magnetic studies. 3.To learn basic methodology of research, chemical literature project report writing. Units – 1

(15 hours)

1.1 Electronics: Basic functions of instrumentation- semiconductor components operational amplifiers- signal to noise ratio – sources of noise – instrument calibration. 1.2 Optical methods of analysis: Colorimetric, UV-Visible spectrophotometric and IR analysis – single and double beam instruments- sampling techniques-working. LASER types and techniques. Raman spectroscopy basic instrumentation-Laser Raman spectroscopy-working. Basic components, instrumentation and working of Mass, NMR & ESR Spectrometers. Unit –II chromatography (15 hours) 2.1 Iron exchange Chromatography: Instrumentation

2.2 Gas liquid chrotomatography – instrumentation, carrier gas columns, stationary phase, Detectors, Thermal conductivity, Flameionisation, Electron capture. 2.3 High Performance Liquid chromatography – instrumentation, pumping systems, columns, column packing, detectors. 2.4 Electrophoresis- instrumentation – application unit-III Electroanalytical Methods

(15 hours)

3.1 Polarography –theory, instrumentation, DME, Diffusion, Kinetic and Catalytic currents, current-voltage curves for reversible and irreversible system, qualitative and quantitative applications. 3.2 Pulse Polarography-Square wave polarography-cyclic voltammetry – theory, instrumentation and applications to inorganic systems. 3.3 Amperometric titrations-theory, instrumentation types of titration curves, successive titrations and indiator electrodes- Applications – Biamperometry, potentiometry, Bipotentiometry. Unit-IV

(30 hours)

4.1 Atomic absorption spectroscopy: theory, atomizers, flame and electrothermal radiation sources, instrumentation, spectral and chemical interferences, applications. 4.2 Photoelectron spectroscopy (UV and X-ray) – Photoelectron, spectrakoopman’s theorem, fine structure in PES, Chemical shift and correlation with electronic charges. 4.3 Radioanalytical methods-Isotope dilution analysis, Radiometric Titrations – radio immuno assay – Neutron activation analysis. 4.4 Magnetic susceptibility and measurements – Guoy method, Faraday method- applications.

Unit-V: Research Methodology.

(15 hours)

5.1 Research Hypothesis – planning and conduction experiments, methodology of collecting scientific data (with three of project title as example) 5.2 Chemistry literature survey- types of chemistry literature-Primary, secondary and tertiary- examples journals published by the ACS and RSC – chemical abstracts (CA) and its importance – Indian journals- reviews – monographs, data books and indexes. Litereature survey: Methods of searching literature, methods of compilation and preservation and retrieval of collected literature. 5.3 Project report writing; The general format, chapter formant and page format. Procedure for presenting tables, graphs and figure, foot – notes, bibliography, appendices. Reference: 1. D.A.Skoog, 1985, Principles of instrumental methods of analysis. III edition, Saunders college publication. 2. Willard merit, Dean and Settle, 1986, Instrumental methods of analysis, VI edition, CBS publication. 3. A.L Vogel, 1985, 1976, text book of Qualitative Inorganic Analysis, ELBS III edition and VI edition. 4.D.A.Skoog and D.M west, 1982, Fundamentals of Analytical chemistry, IV edition, Holt reinheart and Winston publication. 5.Jerry March, 1992, Advanced Organic Chemistry, IV edition, Mc GrawHill. 6.Anderson, Durtson and poole, Thesis and assignment writing. 7. K.V Raman, 1993, Computers in chemistry, Tata McGraw Hill, New Delhi.

Other Reference Books Suggested 1. G.D Christian & J.E.O. Reily, 1986 instrumental analysis II edition, Allegn Becon. 2. H.A Storbital, 1976, chemical instrumentations, Addition – Wesley publication Co. 3. Wilson and Wilson series, comprehensive analytical chemistry. 4. R.C Kapoor and B.S Aggarwal, Ms. 1991, Principles of polarography, Wiley Eastern limited. 5. Kolthoff and Elwing (All series) – Treatise on Analytical chemistry. 6. M.G. Mellon, chemical publications – their nature and uses. 7. K.Ebert, H.Ederes and T.L.Isenhowr, computer applications in chemistry, VCH.

THE NEW COLLEGE (AUTONOMOUS), CHENNAI-14 M.Sc DEGREE: BRANCH –IV CHEMISTRY SYLLABUS (Effective from the year 2008-2009) CORE 12- ORGANIC CHEMISTRY PRACTICAL-II CODE

CREDITS : 4

TEACHING HOURS: 90

OBJECTIVES OF THE COURSE To train the student in the laboratory techniques in the organic compounds involving two or three stages. This paper also includes quantitatives estimation of organic compounds using known methods and basic experience in extraction of compounds from natural products and chromatographic separations. a)Two stages preparation ( any five) 1.Syn-Tribromobenzene from aniline. 2.p-nitro aniline from acetanilide. 3.m-nitrobenzoic acid from methyl benzoate 4.2,4-dinitrobenzoic acid from p-nitro toluene 5.m-nitro benzoic acid from benzaldehyde 6.p-bromoaniline from acetanilide. 7.anthroquinone from phthalic anhydride 8.2-phenyl indole from phenylhydrazine 9.2,4-dinitrophenylhydrazine from p-nitrochlorobenzene 10.Benzanilide from benzophenone b)Estimations : (any four) 1. Estimation of aniline

2. Estimation of phenol 3. Estimation of glucose (Bertrands methods) 4. Saponification of fat or oil 5. Iodine value of oil 6. Estimation of ketone 7. Estimation of amino group 8. Estimation of amide group 9. Estimation of Sulphur in an organic compound.

c) Special Interpretation of organic compound UV, IR, PMR and Mass spectra of the following compound 1.1, 3, 5 - Trimethylbenzene 2. Pinacolone 3. n-prophylamine 4. p-methoxybenzyl alcohol 5. Phenyl acetone 6. Benzyl bromide 7. 2-methoxyethyl acetate 8. Acetone 9. Isopropyl alcohol 10. Acetaldehyde diacetate 11. 2-N, N – Dimethylamino ethanol

12. Pyridine 13.4-Picoline 14.1,3 dibromo – 1, 1-dicholoropropene 15. Cinnamaldehyde d) Exercise in the extraction of natural products: 1. Caffeine from tea leaves 2.Lactose from milk 3. citric acid from lemon 4.Pipierine from black pepper e) Chromatographic separation: 1. Column chromatography-separation of anthracene and picric acid from anthracene picrate 2. Thin layer chromatography-separation of green leaf pigments. 3. Paper chromatography 4. Identification of amino acids