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What are Hormonal drugs in sports? List of Hormonal drugs and mechanism of action From Sportwiki
Contents 1 Hypothalamic hormones drugs 2 Adenohypophysis hormones drugs 3 Neurohypophysis hormone drugs 3.1 Oxytocin 3.2 Vasopressin 3.3 Desmopressin 4 Epiphysis hormones drugs
Hypothalamic hormones drugs Hypothalamus, pituitary, epiphysis, thyroid, parathyroid and pancreas drugs are attributed to peptide hormones. Sermorelin is a synthetic analogue of the natural releasing HGH; it is used for diagnosis. Rifatironin and protirelin are synthetic analogues of tirotropinrilizing hormone, thyroid-stimulating hormone release; it is used for diagnosis. Drugs that stimulate the release of gonadotrophic hormones, depending on the concentration, can stimulate and inhibit the secretion of pituitary hormones. Ganirelix - drug of high antagonistic activity against natural gonadotropin; used for precocious puberty. Cetrorelix- antagonist of luteinizing releasing hormone. Gonadorelin, administered intermittently, increases the production of gonadotropic hormones of the pituitary gland, it is used for the diagnosis and treatment of hypogonadism. Somatostatin - synthetic tetrapeptide analogue of somatostatin and octreotide - somatostatin octapeptide analog. Indications for use: stop the bleeding from esophageal varices.
Adenohypophysis hormones drugs Adenohypophysis hormones play an important role in regulating inscretory function of the endocrine glands. Some of them are in the form of pharmaceuticals and are used for therapeutic purposes. Thyrotropin - thyroid stimulating hormone (TSH) drug specific glycoprotein with a molecular weight of 24 000-30 000. Pharmacodynamics: stimulates the formation and differentiation of interfollicular thyroid epithelium, as well as the production and flow of its hormones in blood - iodinated thyronines. Indications for use: in acute inflammation and hypothyroidism diagnostic purposes.
Neurohypophysis hormone drugs Neurohypophysis hormones - vasopressin and oxytocin are synthesized in the supraoptic and paraventricular nuclei of under area and along the axons of the nerve path of supra optic hypophysis enter the posterior lobe of the pituitary gland, where deposited. Both are octapeptide hormone whose structure and the core contains a cyclic side chain.
Oxytocin Pharmacokinetics: The effect of the drug when administered intravenously develops in 1-2 minutes and lasts for 15-20 minutes. Pharmacodynamics: increases membrane permeability to ions K+, also and intracellular content of Na+ and Ca++, causing reduced capacity and increased cellular excitability, stimulated cyclase system. This leads to a reduction of stimulation of uterine body, especially at the end of pregnancy, decrease in cervical tone. Indications for use: generic weakness, atony of the uterus, hypotonic uterine bleeding, to remove the placenta at caesarean section. Contraindications: mismatch of fetal head size and size of the pelvis, transverse and oblique position of the fetus, threatening uterine rupture. In case of overdose there is a risk of uterine rupture and postpartum haemorrhage.
Vasopressin Pharmacokinetics: The effect of the drug develops within 30-45 minutes after administration. Pharmacodynamics: stimulates the formation of c-AMP, phosphorylates Protein molecules, increases water reabsorption across the apical membrane, has a regulating effect on the reabsorption of water the distal tubules of the kidneys; delays ions Na+, Cl, narrows blood vessels and capillaries, increases blood pressure. Indications: bedwetting, diabetes insipidus. Side effects: Sodium and water retention, increased blood pressure.
Desmopressin Desmopressin - a synthetic polypeptide analog of vasopressin. Pituitrin - formulation comprising oxytocin and vasopressin Pharmacokinetics: Action within 2-3 minutes, duration - 15-20 min. Indications: stimulation and strengthening the contractile activity of the uterus in the primary and secondary of its weakness, hypotonic bleeding, normalization of uterine involution in the postpartum and post-abortion period, bedwetting, diabetes insipidus. Side effects: sodium retention, edema, increased blood pressure. Adiurecrine is a dry pituitrin contains mainly antidiuretic hormone (ADH). Pharmacokinetics: action in 15 to 20 minutes, duration - 6-8 hours. Indications for use: as the antidiuretic agent for diabetes insipidus, nocturnal enuresis. Side effects: chronic allergic rhinitis, resistance to the drug.
Epiphysis hormones drugs Epiphysis plays an important role in the mechanisms of biorhythms. Melatonin is a pineal gland hormone which is produced by acetylation of serotonin and O-methylation. Melatonin normalizes circadian rhythms, speeds up adaptation to rapid change of time zones, normalizes psychoemotional status, regulate neuroendocrine function, exhibits immunostimulatory and antioxidant properties marked neuroprotective properties. Indications for use: as a means of regulating sleep (sleep processes), to normalize the biological rhythm when changing time zones. Side effects: swelling, drowsiness. Retrieved from "http://sportwiki.co/index.php?title=What_are_Hormonal_drugs_in_sports%3F_List_of_Hormonal_drugs_and_mechanism_of_action&oldid=845" Category: Pharmacology This page was last modified on 17 November 2017, at 16:48.
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