When Do Symptoms Become a Disease? - Annals of Internal Medicine [PDF]

May 1, 2001 - for which symptoms might plausibly be linked in a disease con- ... stitute a disease? The investigator or

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CONFERENCES | 1 MAY 2001

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DOI: 10.7326/0003-4819-134-9_Part_2-20010501100002

Robert A. Aronowitz, MD

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Published: Ann Intern Med. 2001;134(9_Part_2):803-

When Do Symptoms Become a Disease?

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Abstract When do symptoms become a disease? Are there rules or norms, currently or in the past, that

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tell us when a particular collection of largely symptom-based criteria has enough specificity,

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utility, or plausibility to justify the appellation disease? The history of numerous symptom-

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consensus conferences, have been used to find or confer specificity in symptom-based

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diagnoses. These strategies are problematic and have generally been used after symptombased diagnoses have been recognized and defined. These historical observations emphasize that although biological and clinical factors have set boundaries for which symptoms might plausibly be linked in a disease concept, social influences have largely determined which symptom clusters have become diseases.

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